PLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.04806151
2regulation of female gonad development (GO:2000194)4.79531780
3female gamete generation (GO:0007292)4.38842459
4low-density lipoprotein particle remodeling (GO:0034374)4.16859056
5very-low-density lipoprotein particle assembly (GO:0034379)4.14025839
6regulation of RIG-I signaling pathway (GO:0039535)4.06910740
7piRNA metabolic process (GO:0034587)3.96071811
8regulation of meiosis (GO:0040020)3.86997414
9glycerophospholipid catabolic process (GO:0046475)3.83512276
10regulation of complement activation (GO:0030449)3.80901839
11plasma lipoprotein particle assembly (GO:0034377)3.80249859
12sphingosine metabolic process (GO:0006670)3.77431501
13regulation of protein activation cascade (GO:2000257)3.73809067
14regulation of cholesterol homeostasis (GO:2000188)3.73654349
15positive regulation of Cdc42 GTPase activity (GO:0043089)3.71977942
16positive regulation of interleukin-1 beta secretion (GO:0050718)3.68233550
17cholesterol efflux (GO:0033344)3.66575728
18microglial cell activation (GO:0001774)3.66226514
19protein-lipid complex remodeling (GO:0034368)3.65012276
20macromolecular complex remodeling (GO:0034367)3.65012276
21plasma lipoprotein particle remodeling (GO:0034369)3.65012276
22diol metabolic process (GO:0034311)3.63727691
23intestinal absorption (GO:0050892)3.58397195
24protein-lipid complex assembly (GO:0065005)3.57327685
25angiotensin maturation (GO:0002003)3.56789816
26negative regulation of protein activation cascade (GO:2000258)3.56054721
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.54042033
28negative regulation of fibrinolysis (GO:0051918)3.49859384
29regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.47399400
30positive regulation of interleukin-1 secretion (GO:0050716)3.45464377
31negative regulation of complement activation (GO:0045916)3.45091809
32female gonad development (GO:0008585)3.43692393
33meiotic cell cycle (GO:0051321)3.41807552
34plasma lipoprotein particle organization (GO:0071827)3.39696462
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39248875
36high-density lipoprotein particle remodeling (GO:0034375)3.37966946
37lipoprotein metabolic process (GO:0042157)3.35816188
38regulation of Cdc42 GTPase activity (GO:0043088)3.33212237
39cellular response to ethanol (GO:0071361)3.32973495
40meiotic chromosome segregation (GO:0045132)3.30684539
41positive regulation of interleukin-1 beta production (GO:0032731)3.30060163
42protein-lipid complex subunit organization (GO:0071825)3.29651240
43negative regulation of keratinocyte proliferation (GO:0010839)3.29292190
44sphingoid metabolic process (GO:0046519)3.28645587
45sulfate transmembrane transport (GO:1902358)3.28334901
46DNA damage induced protein phosphorylation (GO:0006975)3.27106885
47DNA methylation involved in gamete generation (GO:0043046)3.26703498
48regulation of mononuclear cell migration (GO:0071675)3.25734196
49regulation of interleukin-1 beta secretion (GO:0050706)3.21007147
50regulation of meiotic cell cycle (GO:0051445)3.18965556
51complement activation, alternative pathway (GO:0006957)3.16031054
52reverse cholesterol transport (GO:0043691)3.13436291
53myoblast migration (GO:0051451)3.12383260
54purinergic nucleotide receptor signaling pathway (GO:0035590)3.10137184
55regulation of meiosis I (GO:0060631)3.06458991
56positive regulation of interleukin-1 production (GO:0032732)3.04329269
57sulfate transport (GO:0008272)3.04153066
58negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03080469
59desmosome organization (GO:0002934)3.03062335
60regulation of apoptotic cell clearance (GO:2000425)3.00726094
61regulation of cholesterol esterification (GO:0010872)2.99114352
62lipoprotein transport (GO:0042953)2.98078243
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96484103
64epoxygenase P450 pathway (GO:0019373)2.95265431
65phospholipid efflux (GO:0033700)2.95062531
66negative regulation of hormone biosynthetic process (GO:0032353)2.94760690
67negative regulation of hormone metabolic process (GO:0032351)2.94760690
68negative regulation of meiosis (GO:0045835)2.93839865
69regulation of fibrinolysis (GO:0051917)2.93093032
70peptide catabolic process (GO:0043171)2.85810277
71type B pancreatic cell development (GO:0003323)2.85164553
72plasma lipoprotein particle clearance (GO:0034381)2.84729987
73regulation of interleukin-1 secretion (GO:0050704)2.84340373
74parturition (GO:0007567)2.83411268
75oligosaccharide catabolic process (GO:0009313)2.83083154
76glycosphingolipid catabolic process (GO:0046479)2.82695163
77negative regulation of humoral immune response (GO:0002921)2.81042802
78low-density lipoprotein particle clearance (GO:0034383)2.79390277
79macroautophagy (GO:0016236)2.79166000
80oocyte maturation (GO:0001556)2.78591252
81negative regulation of leukocyte migration (GO:0002686)2.77821885
82superoxide anion generation (GO:0042554)2.77404118
83negative regulation of execution phase of apoptosis (GO:1900118)2.77028174
84embryonic digestive tract development (GO:0048566)2.76844792
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.76309532
86regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76037026
87complement activation, classical pathway (GO:0006958)2.76032716
88peptidyl-glutamic acid carboxylation (GO:0017187)2.75033289
89protein carboxylation (GO:0018214)2.75033289
90intestinal cholesterol absorption (GO:0030299)2.73409681
91regulation of keratinocyte proliferation (GO:0010837)2.72065299
92eye photoreceptor cell differentiation (GO:0001754)2.70567047
93photoreceptor cell differentiation (GO:0046530)2.70567047
94flavonoid metabolic process (GO:0009812)2.70394338
95bile acid metabolic process (GO:0008206)2.69811757
96oogenesis (GO:0048477)2.69597932
97negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.68771220
98smooth muscle tissue development (GO:0048745)2.66757363
99regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66611257
100endocrine process (GO:0050886)2.66611257
101regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66611257
102regulation of germinal center formation (GO:0002634)2.66585901
103glycolipid catabolic process (GO:0019377)2.65224874
104positive regulation of steroid metabolic process (GO:0045940)2.64948939
105centriole assembly (GO:0098534)2.63555903
106cellular anion homeostasis (GO:0030002)2.62577348
107regulation of cholesterol storage (GO:0010885)2.62466971
108regulation of exit from mitosis (GO:0007096)2.62423525
109regulation of bile acid biosynthetic process (GO:0070857)2.61596211
110nucleotide transmembrane transport (GO:1901679)2.61596012
111DNA damage response, signal transduction resulting in transcription (GO:0042772)2.59978638
112cholesterol transport (GO:0030301)2.59842411
113sterol transport (GO:0015918)2.59842411
114positive regulation of antigen processing and presentation (GO:0002579)2.59431129
115protein activation cascade (GO:0072376)2.59102017
116protein K6-linked ubiquitination (GO:0085020)2.58054841
117regulation of somitogenesis (GO:0014807)2.57918725
118regulation of platelet aggregation (GO:0090330)2.57251830
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.56489609
120G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.56421570
121negative regulation of hemostasis (GO:1900047)2.56378411
122negative regulation of blood coagulation (GO:0030195)2.56378411
123phospholipid homeostasis (GO:0055091)2.55319695
124preassembly of GPI anchor in ER membrane (GO:0016254)2.55237965
125tongue development (GO:0043586)2.54460448
126negative regulation of reproductive process (GO:2000242)2.53118437
127iron ion import (GO:0097286)2.51020051
128negative regulation of coagulation (GO:0050819)2.48985034
129intestinal epithelial cell development (GO:0060576)2.47571467
130centriole replication (GO:0007099)2.47388547
131complement activation (GO:0006956)2.46938787
132transepithelial transport (GO:0070633)2.46931327
133multicellular organism reproduction (GO:0032504)2.46656068
134regulation of glucocorticoid metabolic process (GO:0031943)2.46150452
135replicative senescence (GO:0090399)2.45426473
136detection of other organism (GO:0098543)2.45345335
137positive regulation of actin filament depolymerization (GO:0030836)2.45020246
138response to redox state (GO:0051775)2.44789832
139bile acid and bile salt transport (GO:0015721)2.44428289
140positive regulation of defense response to virus by host (GO:0002230)2.43799397
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.42784099
142RNA destabilization (GO:0050779)2.42746332
143regulation of vitamin metabolic process (GO:0030656)2.41449974
144dicarboxylic acid biosynthetic process (GO:0043650)2.40224411
145male meiosis (GO:0007140)2.40111144
146positive regulation of triglyceride lipase activity (GO:0061365)2.39126338
147positive regulation of lipoprotein lipase activity (GO:0051006)2.39126338
148mitotic metaphase plate congression (GO:0007080)2.39009356
149cholesterol homeostasis (GO:0042632)2.38392353
150regulation of humoral immune response (GO:0002920)2.38198861
151regulation of acrosome reaction (GO:0060046)2.36344198
152positive regulation of hemostasis (GO:1900048)2.35454342
153positive regulation of blood coagulation (GO:0030194)2.35454342
154positive regulation of meiotic cell cycle (GO:0051446)2.35196013
155negative regulation of myoblast differentiation (GO:0045662)2.35081701
156regulation of antigen processing and presentation (GO:0002577)2.34870612
157positive regulation of meiosis (GO:0045836)2.34793761
158sterol homeostasis (GO:0055092)2.33704232
159fat-soluble vitamin biosynthetic process (GO:0042362)2.33664610
160sodium-independent organic anion transport (GO:0043252)2.33328531
161fibrinolysis (GO:0042730)2.32848558
162regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32459200
163detection of bacterium (GO:0016045)2.32382144
164positive regulation of coagulation (GO:0050820)2.32368542
165regulation of activation of Janus kinase activity (GO:0010533)2.32237890
166phospholipid translocation (GO:0045332)2.32211200
167lipid translocation (GO:0034204)2.32211200
168tight junction assembly (GO:0070830)2.31961156
169trivalent inorganic anion homeostasis (GO:0072506)2.30980935
170phosphate ion homeostasis (GO:0055062)2.30980935
171NIK/NF-kappaB signaling (GO:0038061)2.30967295
172regulation of macrophage chemotaxis (GO:0010758)2.30241225
173negative regulation of granulocyte differentiation (GO:0030853)2.29594550
174ethanol oxidation (GO:0006069)2.29365521
175ceramide catabolic process (GO:0046514)2.29177666
176regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.28940597
177negative regulation of alcohol biosynthetic process (GO:1902931)2.28245151
178negative regulation of meiotic cell cycle (GO:0051447)2.28123110
179negative regulation of cholesterol transport (GO:0032375)2.27775957
180negative regulation of sterol transport (GO:0032372)2.27775957
181drug transmembrane transport (GO:0006855)2.27028936
182detection of molecule of bacterial origin (GO:0032490)2.27020195
183regulation of keratinocyte differentiation (GO:0045616)2.26481557
184regulation of steroid hormone biosynthetic process (GO:0090030)2.26117956
185macrophage activation involved in immune response (GO:0002281)2.25966058
186COPII vesicle coating (GO:0048208)2.24652068
187endothelium development (GO:0003158)2.24384429
188cellular glucuronidation (GO:0052695)2.24327735
189acute-phase response (GO:0006953)2.23793401
190negative regulation of wound healing (GO:0061045)2.18910775
191regulation of metalloenzyme activity (GO:0048552)2.17999922
192positive regulation of steroid biosynthetic process (GO:0010893)2.17587469
193indole-containing compound catabolic process (GO:0042436)2.15241011
194indolalkylamine catabolic process (GO:0046218)2.15241011
195tryptophan catabolic process (GO:0006569)2.15241011
196regulation of membrane protein ectodomain proteolysis (GO:0051043)2.14764889
197positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.14697184
198positive regulation of lipid catabolic process (GO:0050996)2.14214702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human2.99996610
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.98384941
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.93451320
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.81479104
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.78040200
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.65009485
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53274711
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50775705
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.46083815
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.45206374
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.32775172
12GBX2_23144817_ChIP-Seq_PC3_Human2.31705988
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.28915614
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26791751
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24291221
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.22274508
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14416857
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.11934934
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09474834
20EZH2_27294783_Chip-Seq_NPCs_Mouse2.06380599
21* FOXA2_19822575_ChIP-Seq_HepG2_Human2.01718168
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00636242
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95426673
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95361439
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87141698
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.81920838
27* NANOG_18555785_Chip-Seq_ESCs_Mouse1.80955126
28* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80501424
29* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80484807
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80399003
31GATA1_22025678_ChIP-Seq_K562_Human1.79709878
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76082185
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70705153
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70672923
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.68735845
36LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67703507
37* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66816957
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66442930
39GATA4_25053715_ChIP-Seq_YYC3_Human1.64763104
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.64597713
41* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63875201
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58973531
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58511036
44STAT1_17558387_ChIP-Seq_HELA_Human1.58408491
45P53_22387025_ChIP-Seq_ESCs_Mouse1.57345489
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.57280642
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57062858
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.55762342
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55268801
50OCT4_18555785_Chip-Seq_ESCs_Mouse1.54556238
51* NMYC_18555785_Chip-Seq_ESCs_Mouse1.54218038
52* ZFX_18555785_Chip-Seq_ESCs_Mouse1.53479012
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52549468
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52549468
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.52499509
56KLF4_18555785_Chip-Seq_ESCs_Mouse1.52004754
57* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51869900
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51574465
59SOX2_18555785_Chip-Seq_ESCs_Mouse1.50871160
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.49340196
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49245823
62AHR_22903824_ChIP-Seq_MCF-7_Human1.47887127
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.47733368
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46686508
65P300_18555785_Chip-Seq_ESCs_Mouse1.45552318
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44676057
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44676057
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44495456
69* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44235115
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42795438
71FUS_26573619_Chip-Seq_HEK293_Human1.41594821
72* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40090928
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.39417477
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.38889722
75PU1_27457419_Chip-Seq_LIVER_Mouse1.38094452
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37832000
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37802564
78GATA1_19941826_ChIP-Seq_K562_Human1.37302775
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.35673001
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35159366
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.35079478
82TP53_16413492_ChIP-PET_HCT116_Human1.35041704
83GATA2_19941826_ChIP-Seq_K562_Human1.34710900
84* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34015860
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33126219
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.31923243
87* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31682543
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.31025747
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29355593
90* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29153796
91* CDX2_22108803_ChIP-Seq_LS180_Human1.26781897
92* TP63_23658742_ChIP-Seq_EP156T_Human1.26774185
93NFYA_21822215_ChIP-Seq_K562_Human1.26288345
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26015909
95* STAT3_23295773_ChIP-Seq_U87_Human1.25418096
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25343943
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24915913
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24593112
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23347335
100* CJUN_26792858_Chip-Seq_BT549_Human1.21952640
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.21646331
102* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21440771
103VDR_24787735_ChIP-Seq_THP-1_Human1.20687079
104TBL1_22424771_ChIP-Seq_293T_Human1.20438190
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19329745
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19218632
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17872059
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.17277211
109P300_19829295_ChIP-Seq_ESCs_Human1.17185012
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17161100
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16538242
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16085989
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14858308
114KDM2B_26808549_Chip-Seq_REH_Human1.13422542
115IGF1R_20145208_ChIP-Seq_DFB_Human1.12687824
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.12530223
117EWS_26573619_Chip-Seq_HEK293_Human1.12442967
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11885807
119ESR1_21235772_ChIP-Seq_MCF-7_Human1.11611695
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11361607
121* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10881486
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10179632
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.09800371
124RXR_22108803_ChIP-Seq_LS180_Human1.09619389
125EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08863290
126GATA1_26923725_Chip-Seq_HPCs_Mouse1.08764919
127* GATA2_21666600_ChIP-Seq_HMVEC_Human1.08335588
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.08308003
129SMAD4_21799915_ChIP-Seq_A2780_Human1.07421368
130* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07257938
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06694614
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05878630
133* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05796148
134HNFA_21074721_ChIP-Seq_CACO-2_Human1.05664831
135ESR1_20079471_ChIP-ChIP_T-47D_Human1.05589054
136* GATA6_25053715_ChIP-Seq_YYC3_Human1.05404426
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04870401
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04505260
139SPI1_23127762_ChIP-Seq_K562_Human1.03626675
140* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02493817
141NFYB_21822215_ChIP-Seq_K562_Human1.02247078
142SOX2_20726797_ChIP-Seq_SW620_Human1.01690250
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01643061
144* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01505066
145* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01505066
146* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01347132
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00671255
148RUNX_20019798_ChIP-Seq_JUKART_Human1.00258002
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.99100844
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99038509
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98432956
152RNF2_27304074_Chip-Seq_NSC_Mouse0.98405449
153PHF8_20622853_ChIP-Seq_HELA_Human0.98338086
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.98144510
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.98144510
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97941815
157GF1_26923725_Chip-Seq_HPCs_Mouse0.97890143
158GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97549329
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95942514
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.94754207
161* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94455580
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93678823
163GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93118916
164NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92872533
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92768997
166BCAT_22108803_ChIP-Seq_LS180_Human0.92468467
167HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92417229
168TP53_18474530_ChIP-ChIP_U2OS_Human0.92370305
169* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91633388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.79158281
2MP0000566_synostosis4.21427157
3MP0005360_urolithiasis3.91904766
4MP0005451_abnormal_body_composition3.86510469
5MP0002102_abnormal_ear_morphology3.57705757
6MP0003718_maternal_effect3.52160502
7MP0009840_abnormal_foam_cell3.10951791
8MP0005365_abnormal_bile_salt3.03962751
9MP0005085_abnormal_gallbladder_physiolo3.01080146
10MP0001346_abnormal_lacrimal_gland2.75131761
11MP0002254_reproductive_system_inflammat2.55442277
12MP0006054_spinal_hemorrhage2.53155315
13MP0005310_abnormal_salivary_gland2.53018494
14MP0000462_abnormal_digestive_system2.45302193
15MP0003195_calcinosis2.40385333
16MP0003183_abnormal_peptide_metabolism2.38322390
17MP0000383_abnormal_hair_follicle2.37727822
18MP0002277_abnormal_respiratory_mucosa2.34333293
19MP0000579_abnormal_nail_morphology2.30071805
20MP0005058_abnormal_lysosome_morphology2.29625290
21MP0008004_abnormal_stomach_pH2.26705337
22MP0003136_yellow_coat_color2.16352913
23MP0006082_CNS_inflammation2.14974244
24MP0001873_stomach_inflammation2.09746368
25MP0005167_abnormal_blood-brain_barrier2.08059905
26MP0010368_abnormal_lymphatic_system2.02982414
27MP0010329_abnormal_lipoprotein_level2.01743354
28MP0010234_abnormal_vibrissa_follicle2.01387715
29MP0008875_abnormal_xenobiotic_pharmacok2.00615685
30MP0006292_abnormal_olfactory_placode1.96216962
31MP0003303_peritoneal_inflammation1.95846738
32MP0005395_other_phenotype1.95735691
33MP0001851_eye_inflammation1.89820613
34MP0010678_abnormal_skin_adnexa1.83211102
35MP0001119_abnormal_female_reproductive1.77887088
36MP0004272_abnormal_basement_membrane1.76641784
37MP0009697_abnormal_copulation1.72092452
38MP0005275_abnormal_skin_tensile1.71270164
39MP0004264_abnormal_extraembryonic_tissu1.70910619
40MP0008438_abnormal_cutaneous_collagen1.61880829
41MP0001835_abnormal_antigen_presentation1.61613599
42MP0003172_abnormal_lysosome_physiology1.60645310
43MP0003252_abnormal_bile_duct1.56600241
44MP0005671_abnormal_response_to1.55766388
45MP0005408_hypopigmentation1.54193616
46MP0005645_abnormal_hypothalamus_physiol1.53830485
47MP0004381_abnormal_hair_follicle1.53213628
48MP0002876_abnormal_thyroid_physiology1.51697803
49MP0003656_abnormal_erythrocyte_physiolo1.51026218
50MP0000604_amyloidosis1.46335408
51MP0002249_abnormal_larynx_morphology1.43058808
52MP0004019_abnormal_vitamin_homeostasis1.37735859
53MP0003699_abnormal_female_reproductive1.37110771
54MP0003693_abnormal_embryo_hatching1.35437716
55MP0003937_abnormal_limbs/digits/tail_de1.34961638
56MP0000569_abnormal_digit_pigmentation1.34915660
57MP0001986_abnormal_taste_sensitivity1.34609342
58MP0005171_absent_coat_pigmentation1.31252132
59MP0002148_abnormal_hypersensitivity_rea1.30623945
60MP0001188_hyperpigmentation1.29681562
61MP0010155_abnormal_intestine_physiology1.26985287
62MP0000490_abnormal_crypts_of1.26912899
63MP0002396_abnormal_hematopoietic_system1.24729995
64MP0005464_abnormal_platelet_physiology1.24218375
65MP0000609_abnormal_liver_physiology1.24211494
66MP0002118_abnormal_lipid_homeostasis1.21678652
67MP0010352_gastrointestinal_tract_polyps1.21537600
68MP0005257_abnormal_intraocular_pressure1.20757306
69MP0003868_abnormal_feces_composition1.20732631
70MP0005332_abnormal_amino_acid1.18647304
71MP0004043_abnormal_pH_regulation1.18622330
72MP0005164_abnormal_response_to1.18567706
73MP0003191_abnormal_cellular_cholesterol1.18173399
74MP0005381_digestive/alimentary_phenotyp1.17525052
75MP0009384_cardiac_valve_regurgitation1.16123615
76MP0003690_abnormal_glial_cell1.15353682
77MP0003566_abnormal_cell_adhesion1.13840861
78MP0003950_abnormal_plasma_membrane1.13626878
79MP0003045_fibrosis1.13030323
80MP0003436_decreased_susceptibility_to1.12972636
81MP0001790_abnormal_immune_system1.12939217
82MP0005387_immune_system_phenotype1.12939217
83MP0000427_abnormal_hair_cycle1.12544070
84MP0003453_abnormal_keratinocyte_physiol1.11832184
85MP0002998_abnormal_bone_remodeling1.11410033
86MP0003724_increased_susceptibility_to1.11115881
87MP0009785_altered_susceptibility_to1.10518399
88MP0000613_abnormal_salivary_gland1.10187694
89MP0002419_abnormal_innate_immunity1.09824239
90MP0005023_abnormal_wound_healing1.09751606
91MP0005165_increased_susceptibility_to1.09678375
92MP0005197_abnormal_uvea_morphology1.08542230
93MP0005647_abnormal_sex_gland1.07348754
94MP0009764_decreased_sensitivity_to1.06317405
95MP0000685_abnormal_immune_system1.05508095
96MP0004147_increased_porphyrin_level1.05090370
97MP0004484_altered_response_of1.04686495
98MP0008058_abnormal_DNA_repair1.04392916
99MP0009333_abnormal_splenocyte_physiolog1.03690658
100MP0004510_myositis1.02845671
101MP0008877_abnormal_DNA_methylation1.02030446
102MP0000249_abnormal_blood_vessel1.01387824
103MP0004782_abnormal_surfactant_physiolog1.00237579
104MP0005409_darkened_coat_color1.00157162
105MP0003763_abnormal_thymus_physiology0.99759230
106MP0003329_amyloid_beta_deposits0.98420443
107MP0001915_intracranial_hemorrhage0.97942399
108MP0009643_abnormal_urine_homeostasis0.97908221
109MP0000920_abnormal_myelination0.96562762
110MP0003828_pulmonary_edema0.96479330
111MP0004947_skin_inflammation0.94986157
112MP0005166_decreased_susceptibility_to0.94485142
113MP0001533_abnormal_skeleton_physiology0.94199853
114MP0000653_abnormal_sex_gland0.93953825
115MP0002166_altered_tumor_susceptibility0.92998667
116MP0001663_abnormal_digestive_system0.92450793
117MP0000538_abnormal_urinary_bladder0.92235661
118MP0002098_abnormal_vibrissa_morphology0.92132914
119MP0008469_abnormal_protein_level0.92054268
120MP0002168_other_aberrant_phenotype0.91225047
121MP0001485_abnormal_pinna_reflex0.91102436
122MP0003075_altered_response_to0.90927222
123MP0000371_diluted_coat_color0.90795783
124MP0000470_abnormal_stomach_morphology0.90742537
125MP0001929_abnormal_gametogenesis0.89952201
126MP0009115_abnormal_fat_cell0.89084928
127MP0002928_abnormal_bile_duct0.87425496
128MP0002877_abnormal_melanocyte_morpholog0.87225883
129MP0003091_abnormal_cell_migration0.86967893
130MP0002653_abnormal_ependyma_morphology0.86888055
131MP0004084_abnormal_cardiac_muscle0.85414249
132MP0004215_abnormal_myocardial_fiber0.84697655
133MP0002452_abnormal_antigen_presenting0.83100149
134MP0002933_joint_inflammation0.82758372
135MP0000767_abnormal_smooth_muscle0.81667064
136MP0002138_abnormal_hepatobiliary_system0.81440224
137MP0002210_abnormal_sex_determination0.81261661
138MP0005636_abnormal_mineral_homeostasis0.80914214
139MP0002163_abnormal_gland_morphology0.80538697
140MP0008007_abnormal_cellular_replicative0.80526928
141MP0001666_abnormal_nutrient_absorption0.80244879
142MP0010386_abnormal_urinary_bladder0.79247548
143MP0005319_abnormal_enzyme/_coenzyme0.78674795
144MP0002132_abnormal_respiratory_system0.77746644
145MP0003300_gastrointestinal_ulcer0.76571823
146MP0001845_abnormal_inflammatory_respons0.76516416
147MP0001800_abnormal_humoral_immune0.76516364
148MP0000465_gastrointestinal_hemorrhage0.75338068
149MP0002405_respiratory_system_inflammati0.75207610
150MP0001879_abnormal_lymphatic_vessel0.75042417
151MP0002938_white_spotting0.73898976
152MP0000372_irregular_coat_pigmentation0.73599215
153MP0002177_abnormal_outer_ear0.73597633
154MP0001661_extended_life_span0.73403264
155MP0005025_abnormal_response_to0.73285218
156MP0002796_impaired_skin_barrier0.73061233
157MP0000343_altered_response_to0.72743503
158MP0010094_abnormal_chromosome_stability0.72272878
159MP0002896_abnormal_bone_mineralization0.71595450
160MP0002136_abnormal_kidney_physiology0.71539818
161MP0001765_abnormal_ion_homeostasis0.71518240
162MP0005379_endocrine/exocrine_gland_phen0.71329964
163MP0002723_abnormal_immune_serum0.70721450
164MP0009250_abnormal_appendicular_skeleto0.70369564
165MP0005000_abnormal_immune_tolerance0.70010511

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)4.94302190
2Chromsome breakage (HP:0040012)4.86588889
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68519806
4Deep venous thrombosis (HP:0002625)4.23646152
5Prostate neoplasm (HP:0100787)4.08768078
6Hypobetalipoproteinemia (HP:0003563)3.93877437
7Abnormality of complement system (HP:0005339)3.83592641
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67736813
9Right ventricular cardiomyopathy (HP:0011663)3.60669716
10Xanthomatosis (HP:0000991)3.45173437
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.42115267
12Abnormality of glycolipid metabolism (HP:0010969)3.42115267
13Abnormality of liposaccharide metabolism (HP:0010968)3.42115267
14Joint hemorrhage (HP:0005261)3.39336647
15Congenital sensorineural hearing impairment (HP:0008527)3.26540900
16Abnormality of the common coagulation pathway (HP:0010990)3.25938918
17Prolonged partial thromboplastin time (HP:0003645)3.23690807
18Male infertility (HP:0003251)3.16909351
19Abnormality of proline metabolism (HP:0010907)3.14644710
20Hydroxyprolinuria (HP:0003080)3.14644710
21Acanthocytosis (HP:0001927)3.13698482
22Lip pit (HP:0100267)3.12554488
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07383136
24Hemorrhage of the eye (HP:0011885)3.06330566
25Nephritis (HP:0000123)2.99693439
26Hypergonadotropic hypogonadism (HP:0000815)2.98969549
27Flat acetabular roof (HP:0003180)2.93626361
28Mucopolysacchariduria (HP:0008155)2.90178369
29Urinary glycosaminoglycan excretion (HP:0003541)2.90178369
30Dysostosis multiplex (HP:0000943)2.89440333
31Chronic diarrhea (HP:0002028)2.88902738
32Epidermoid cyst (HP:0200040)2.81560237
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80107424
34Abnormality of polysaccharide metabolism (HP:0011012)2.80107424
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80107424
36Fat malabsorption (HP:0002630)2.78364051
37Malnutrition (HP:0004395)2.76250649
38Hypolipoproteinemia (HP:0010981)2.64482294
39Ectopic kidney (HP:0000086)2.64354617
40Intrahepatic cholestasis (HP:0001406)2.61180906
41Arterial tortuosity (HP:0005116)2.57612832
42Myocardial infarction (HP:0001658)2.57400888
43Abnormality of the fingertips (HP:0001211)2.56748734
44Recurrent gram-negative bacterial infections (HP:0005420)2.56722104
45Adrenal hypoplasia (HP:0000835)2.56542066
46Recurrent bacterial skin infections (HP:0005406)2.56375510
47Urethral obstruction (HP:0000796)2.55477751
48Abnormality of the renal collecting system (HP:0004742)2.55205178
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.51382933
50Clubbing of toes (HP:0100760)2.48696769
51Abnormality of the preputium (HP:0100587)2.47673975
52Vacuolated lymphocytes (HP:0001922)2.46514187
53Skin nodule (HP:0200036)2.46283610
54Stomach cancer (HP:0012126)2.44510290
55Hypoplasia of the fovea (HP:0007750)2.42013987
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.42013987
57Duplicated collecting system (HP:0000081)2.41722180
58Retrobulbar optic neuritis (HP:0100654)2.41625516
59Optic neuritis (HP:0100653)2.41625516
60Oligodactyly (hands) (HP:0001180)2.41347776
61Submucous cleft hard palate (HP:0000176)2.37913514
62White forelock (HP:0002211)2.37367363
63Amyloidosis (HP:0011034)2.36659117
64Intestinal atresia (HP:0011100)2.36040612
65Esophageal varix (HP:0002040)2.35039140
66Gingival bleeding (HP:0000225)2.34815496
67Menorrhagia (HP:0000132)2.33472521
68Flat capital femoral epiphysis (HP:0003370)2.32759654
69Recurrent abscess formation (HP:0002722)2.32475439
70Orchitis (HP:0100796)2.29937567
71Mitral stenosis (HP:0001718)2.29217110
72Conjugated hyperbilirubinemia (HP:0002908)2.29203572
73Chronic mucocutaneous candidiasis (HP:0002728)2.27262422
74Recurrent cutaneous fungal infections (HP:0011370)2.27262422
75Patchy hypopigmentation of hair (HP:0011365)2.26390403
76Midline defect of the nose (HP:0004122)2.25866380
77Abnormality of incisor morphology (HP:0011063)2.21664908
78Spondylolisthesis (HP:0003302)2.20901414
79Aplasia cutis congenita (HP:0001057)2.19579426
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19396952
81Keratoconjunctivitis (HP:0001096)2.17557030
82Abnormality of chromosome stability (HP:0003220)2.16961127
83Increased cerebral lipofuscin (HP:0011813)2.16597610
84Decreased circulating renin level (HP:0003351)2.16356122
85Vascular tortuosity (HP:0004948)2.16224560
86Vascular calcification (HP:0004934)2.15495001
87Hematochezia (HP:0002573)2.14803677
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14355249
89Cardiovascular calcification (HP:0011915)2.12256587
90Hypercholesterolemia (HP:0003124)2.12078199
91Pigmentary retinal degeneration (HP:0001146)2.08358253
92Myositis (HP:0100614)2.06857271
93Capillary hemangiomas (HP:0005306)2.06652991
94Duplication of thumb phalanx (HP:0009942)2.05976293
95Ileus (HP:0002595)2.05913270
96Neurofibrillary tangles (HP:0002185)2.05889446
97Recurrent skin infections (HP:0001581)2.05464637
98Tetraparesis (HP:0002273)2.02920360
99Abnormality of the fovea (HP:0000493)2.02888161
100Ectropion (HP:0000656)2.00822421
101Acute myeloid leukemia (HP:0004808)2.00369511
102Fair hair (HP:0002286)2.00287838
103Abnormality of carpal bone ossification (HP:0006257)2.00018771
104Glomerulonephritis (HP:0000099)1.99897065
105Eczematoid dermatitis (HP:0000976)1.99744099
106Autoimmune thrombocytopenia (HP:0001973)1.99091691
107Papillary thyroid carcinoma (HP:0002895)1.99014704
108Split foot (HP:0001839)1.98962458
109Anomalous pulmonary venous return (HP:0010772)1.98304485
110Metaphyseal irregularity (HP:0003025)1.98048224
111Portal hypertension (HP:0001409)1.97207603
112Polycythemia (HP:0001901)1.96764549
113Ovoid vertebral bodies (HP:0003300)1.96120414
114Abnormality of the hepatic vasculature (HP:0006707)1.95134283
115Abnormality of the prostate (HP:0008775)1.94050819
116Small intestinal stenosis (HP:0012848)1.93703687
117Duodenal stenosis (HP:0100867)1.93703687
118Meckel diverticulum (HP:0002245)1.92314064
119Partial duplication of thumb phalanx (HP:0009944)1.91236026
120Anal stenosis (HP:0002025)1.91004069
121Intestinal fistula (HP:0100819)1.90621095
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.89811839
123Asymmetric septal hypertrophy (HP:0001670)1.88473431
124Hypoplastic iliac wings (HP:0002866)1.88430706
125Abnormality of the duodenum (HP:0002246)1.88429027
126Coarse hair (HP:0002208)1.87874900
127Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87279454
128Palmoplantar hyperkeratosis (HP:0000972)1.85547593
129Abnormality of macrophages (HP:0004311)1.84351630
130Proximal tubulopathy (HP:0000114)1.84279654
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84270601
132Systemic lupus erythematosus (HP:0002725)1.83929278
133Pustule (HP:0200039)1.83485608
134Abnormality of the periventricular white matter (HP:0002518)1.82864081
135Abnormality of the pulmonary veins (HP:0011718)1.81872497
136Conical tooth (HP:0000698)1.81702475
137Bifid scrotum (HP:0000048)1.81629914
138Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78681569
139Dysmetric saccades (HP:0000641)1.78471290
140Reduced antithrombin III activity (HP:0001976)1.78391339
141Steatorrhea (HP:0002570)1.77294063
142Syncope (HP:0001279)1.77230520
143Aplasia/hypoplasia of the uterus (HP:0008684)1.77152853
144Abnormality of small intestinal villus morphology (HP:0011472)1.76934554
145Villous atrophy (HP:0011473)1.76934554
146Weak cry (HP:0001612)1.76312559
147Abnormality of the lumbar spine (HP:0100712)1.75659531
148Recurrent pneumonia (HP:0006532)1.75628385
149Type 2 muscle fiber atrophy (HP:0003554)1.75579642
150Gastrointestinal atresia (HP:0002589)1.75236663
151Abnormal tarsal ossification (HP:0008369)1.75008549
152Neonatal death (HP:0003811)1.74805415
153Hypoplasia of the uterus (HP:0000013)1.74457955
154Alopecia of scalp (HP:0002293)1.74298225
155Poikilocytosis (HP:0004447)1.73378070
156Abnormality of the ileum (HP:0001549)1.73108350
157Abnormality of the intrinsic pathway (HP:0010989)1.72952607
158Cerebral aneurysm (HP:0004944)1.71965706
159Abnormality of transition element cation homeostasis (HP:0011030)1.71584424
160Shawl scrotum (HP:0000049)1.70593447
161Breast hypoplasia (HP:0003187)1.70490421
162Spontaneous hematomas (HP:0007420)1.69610218
163Facial shape deformation (HP:0011334)1.69602936
164Potter facies (HP:0002009)1.69602936
165Gangrene (HP:0100758)1.68838257
166Nonprogressive disorder (HP:0003680)1.68783632
167Pulmonary artery stenosis (HP:0004415)1.68755399
168Gastrointestinal infarctions (HP:0005244)1.67848983
169Flared iliac wings (HP:0002869)1.67704146
170Epistaxis (HP:0000421)1.66895299
171Tetany (HP:0001281)1.66418511
172Palmar hyperkeratosis (HP:0010765)1.66106447
173True hermaphroditism (HP:0010459)1.65132254
174Pulmonary fibrosis (HP:0002206)1.64776175
175Amniotic constriction ring (HP:0009775)1.63500838
176Abnormality of placental membranes (HP:0011409)1.63500838
177Pancreatic cysts (HP:0001737)1.62733189
178Upper limb muscle weakness (HP:0003484)1.61498771
179Rectal fistula (HP:0100590)1.59823513
180Rectovaginal fistula (HP:0000143)1.59823513
181Cystic liver disease (HP:0006706)1.58755840
182Fibular aplasia (HP:0002990)1.58261255
183Renal dysplasia (HP:0000110)1.56606731
184Aplasia/Hypoplasia involving the musculature (HP:0001460)1.55514651
185Oligodactyly (HP:0012165)1.54554691
186Pancreatic fibrosis (HP:0100732)1.53905704
187Renal cortical cysts (HP:0000803)1.53496521
188Cupped ear (HP:0000378)1.52310854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.71952338
2ACVR1B3.62717358
3TAOK33.09333934
4PLK43.02912692
5MUSK2.98696009
6STK38L2.69078085
7BMPR22.52628563
8TTK2.50248620
9CDK82.49953793
10FGFR32.43573887
11NUAK12.25558865
12FGFR42.23188938
13ERBB42.20862031
14IRAK32.16389133
15MST1R2.16068833
16MAP3K62.12555487
17TNIK1.98063529
18AKT31.94140950
19NLK1.93002331
20RIPK11.91252655
21DDR21.88430077
22MOS1.87796241
23IRAK41.87015646
24MAP3K131.80832653
25FER1.79531973
26ZAK1.71579050
27MAP3K21.68056155
28NEK91.67977167
29EPHA31.67674448
30CDK91.67220916
31BMPR1B1.66424015
32TXK1.59915198
33ERN11.59144491
34MET1.49461466
35CDK31.49018759
36MAPKAPK51.45936657
37STK31.45206186
38BRAF1.44007233
39EPHB11.43868001
40NEK61.43109553
41FRK1.33479339
42IKBKE1.29123834
43INSRR1.28576919
44MAP3K141.27410995
45RIPK41.23147969
46MELK1.22516828
47IRAK11.22027429
48LATS21.17147479
49STK101.16581972
50PDGFRA1.15955663
51OXSR11.14920927
52PDPK11.12310107
53MAPK151.12308886
54CHEK21.11232444
55TRPM71.10212395
56CDC42BPA1.08235539
57TGFBR21.07471206
58ICK1.05996596
59CHUK1.03414147
60EIF2AK21.03143600
61WNK11.02881842
62MYLK1.01324405
63PDK10.98496930
64MAP3K70.98067414
65TYK20.95773998
66MAPK130.95024242
67CDK120.92326074
68MAPKAPK30.90834268
69RAF10.89546181
70RET0.88949998
71IKBKB0.88768692
72JAK20.87481279
73MAPK110.84629749
74ZAP700.84029287
75PIK3CG0.83764609
76DYRK20.83185050
77MAP3K10.82806466
78EIF2AK30.81784797
79WNK40.81578984
80PDK20.81459004
81TEC0.80029464
82PDGFRB0.79674939
83CSK0.79267777
84GRK10.78417999
85DMPK0.77790506
86IRAK20.77205477
87PRKD20.73537418
88CAMK1D0.72382374
89MKNK20.71002150
90CAMKK20.70352629
91DYRK30.69705538
92FGR0.68809134
93SGK20.67761536
94LMTK20.66625533
95ARAF0.64113527
96ITK0.64083583
97KIT0.63717642
98* PRKAA20.63688082
99PKN10.63629593
100JAK10.62192523
101VRK10.62135951
102MAP3K30.61893443
103PKN20.61522140
104GRK70.59462943
105ADRBK20.59414301
106MST40.59308944
107HIPK20.59042287
108MAP2K60.56337775
109MAP3K50.56269128
110CSF1R0.55566004
111MAPK70.55533635
112MARK20.55504865
113TAOK10.52806159
114FLT30.52761645
115CAMK1G0.52142394
116SYK0.51371891
117STK240.51232554
118ABL10.48503412
119CASK0.47791923
120PLK10.47737006
121SGK4940.47705253
122SGK2230.47705253
123IGF1R0.47404412
124EEF2K0.46440721
125ERBB20.46326914
126SGK10.46176398
127TGFBR10.45156055
128FGFR10.45089341
129PBK0.44360509
130AURKB0.44259914
131PTK2B0.43919443
132PRKAA10.43823871
133PIK3CA0.43437004
134CSNK1G10.43226218
135TIE10.42827763
136KSR20.42785224
137RPS6KA40.42131519
138PTK20.42114072
139KDR0.42002293
140SGK30.41848861
141JAK30.41698911
142PRKACG0.41450694
143LYN0.41000727
144TBK10.40445745
145CDK60.40440864
146EPHA20.40268528
147OBSCN0.40163907
148YES10.37726840
149SIK30.37685224
150MATK0.36447451
151STK390.35015929
152PRKG20.34066261
153BLK0.33573123
154SRPK10.32342848

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.21335877
2Other glycan degradation_Homo sapiens_hsa005112.41531363
3* Ether lipid metabolism_Homo sapiens_hsa005652.38850516
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29852025
5Linoleic acid metabolism_Homo sapiens_hsa005912.27893405
6Ovarian steroidogenesis_Homo sapiens_hsa049132.24529914
7Arachidonic acid metabolism_Homo sapiens_hsa005902.18775160
8Basal transcription factors_Homo sapiens_hsa030222.14402439
9Sphingolipid metabolism_Homo sapiens_hsa006002.09408724
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05253975
11PPAR signaling pathway_Homo sapiens_hsa033201.89790426
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82609190
13Fanconi anemia pathway_Homo sapiens_hsa034601.81614992
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.79219754
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76071833
16Vitamin digestion and absorption_Homo sapiens_hsa049771.75507226
17Circadian rhythm_Homo sapiens_hsa047101.72501448
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.70838101
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69011927
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.65613323
21Arginine biosynthesis_Homo sapiens_hsa002201.63638349
22Non-homologous end-joining_Homo sapiens_hsa034501.60411943
23Histidine metabolism_Homo sapiens_hsa003401.53531368
24Fatty acid degradation_Homo sapiens_hsa000711.53268295
25Homologous recombination_Homo sapiens_hsa034401.50014427
26Mineral absorption_Homo sapiens_hsa049781.48191605
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47826533
28Tryptophan metabolism_Homo sapiens_hsa003801.46577508
29Fatty acid biosynthesis_Homo sapiens_hsa000611.42836859
30Cell cycle_Homo sapiens_hsa041101.42214221
31Staphylococcus aureus infection_Homo sapiens_hsa051501.41518772
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.38137646
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.37901091
34RNA degradation_Homo sapiens_hsa030181.37834477
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36078056
36Bile secretion_Homo sapiens_hsa049761.33244555
37Lysosome_Homo sapiens_hsa041421.32193516
38TGF-beta signaling pathway_Homo sapiens_hsa043501.28668650
39Hematopoietic cell lineage_Homo sapiens_hsa046401.26905811
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25894167
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.21880125
42Vitamin B6 metabolism_Homo sapiens_hsa007501.21552725
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.17803568
44Steroid biosynthesis_Homo sapiens_hsa001001.17279184
45p53 signaling pathway_Homo sapiens_hsa041151.16234751
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14814037
47Pertussis_Homo sapiens_hsa051331.13880378
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13152262
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12901858
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06472812
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02312870
52Adherens junction_Homo sapiens_hsa045200.98604911
53MicroRNAs in cancer_Homo sapiens_hsa052060.97497532
54Malaria_Homo sapiens_hsa051440.95808974
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94756245
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.93863670
57TNF signaling pathway_Homo sapiens_hsa046680.93498167
58Autoimmune thyroid disease_Homo sapiens_hsa053200.92926221
59Herpes simplex infection_Homo sapiens_hsa051680.92362988
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.91798380
61* Pancreatic cancer_Homo sapiens_hsa052120.91156997
62Fructose and mannose metabolism_Homo sapiens_hsa000510.90594021
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89933649
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88831693
65Small cell lung cancer_Homo sapiens_hsa052220.88723289
66Caffeine metabolism_Homo sapiens_hsa002320.88665480
67Galactose metabolism_Homo sapiens_hsa000520.88454806
68Dorso-ventral axis formation_Homo sapiens_hsa043200.87924840
69Osteoclast differentiation_Homo sapiens_hsa043800.86561922
70Phenylalanine metabolism_Homo sapiens_hsa003600.86374526
71Retinol metabolism_Homo sapiens_hsa008300.85182158
72Glycerolipid metabolism_Homo sapiens_hsa005610.85123241
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84876574
74ABC transporters_Homo sapiens_hsa020100.83666216
75Fatty acid metabolism_Homo sapiens_hsa012120.82680906
76Leishmaniasis_Homo sapiens_hsa051400.81942238
77Insulin resistance_Homo sapiens_hsa049310.81114781
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80690034
79Notch signaling pathway_Homo sapiens_hsa043300.80498613
80Primary immunodeficiency_Homo sapiens_hsa053400.79539335
81Asthma_Homo sapiens_hsa053100.78694694
82Protein digestion and absorption_Homo sapiens_hsa049740.78559246
83Amoebiasis_Homo sapiens_hsa051460.78212309
84Influenza A_Homo sapiens_hsa051640.76836313
85Folate biosynthesis_Homo sapiens_hsa007900.76673154
86Measles_Homo sapiens_hsa051620.76483764
87ECM-receptor interaction_Homo sapiens_hsa045120.75642090
88Fat digestion and absorption_Homo sapiens_hsa049750.75065778
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72339071
90African trypanosomiasis_Homo sapiens_hsa051430.71729427
91Butanoate metabolism_Homo sapiens_hsa006500.71342031
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.70369287
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70010755
94Tyrosine metabolism_Homo sapiens_hsa003500.68807785
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65298293
96Toxoplasmosis_Homo sapiens_hsa051450.64938092
97Prion diseases_Homo sapiens_hsa050200.62844079
98RNA polymerase_Homo sapiens_hsa030200.62463667
99Rheumatoid arthritis_Homo sapiens_hsa053230.62091989
100Hepatitis B_Homo sapiens_hsa051610.60726952
101Nitrogen metabolism_Homo sapiens_hsa009100.60248604
102Chemokine signaling pathway_Homo sapiens_hsa040620.60001791
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59615363
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59299284
105* Glycerophospholipid metabolism_Homo sapiens_hsa005640.58819515
106Renin-angiotensin system_Homo sapiens_hsa046140.58105030
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57441934
108Hepatitis C_Homo sapiens_hsa051600.57142441
109Prolactin signaling pathway_Homo sapiens_hsa049170.57024002
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56035528
111Starch and sucrose metabolism_Homo sapiens_hsa005000.55234869
112Prostate cancer_Homo sapiens_hsa052150.55087342
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54939855
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53584042
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53412967
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51076668
117Basal cell carcinoma_Homo sapiens_hsa052170.49985490
118Lysine degradation_Homo sapiens_hsa003100.49730179
119Pancreatic secretion_Homo sapiens_hsa049720.49554221
120Apoptosis_Homo sapiens_hsa042100.48993444
121Platelet activation_Homo sapiens_hsa046110.48624916
122Arginine and proline metabolism_Homo sapiens_hsa003300.48086649
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47688542
124Chemical carcinogenesis_Homo sapiens_hsa052040.46753446
125Allograft rejection_Homo sapiens_hsa053300.46692095
126Sulfur metabolism_Homo sapiens_hsa009200.46626465
127Tuberculosis_Homo sapiens_hsa051520.46093030
128Melanoma_Homo sapiens_hsa052180.46021178
129* Choline metabolism in cancer_Homo sapiens_hsa052310.45497204
130* Ras signaling pathway_Homo sapiens_hsa040140.45099098
131Graft-versus-host disease_Homo sapiens_hsa053320.44720941
132Thyroid hormone synthesis_Homo sapiens_hsa049180.44615268
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44152239
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43511398
135Peroxisome_Homo sapiens_hsa041460.42408559
136FoxO signaling pathway_Homo sapiens_hsa040680.42151660
137Glutathione metabolism_Homo sapiens_hsa004800.41236736
138Renin secretion_Homo sapiens_hsa049240.40233226
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40061266
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.36944923
141Focal adhesion_Homo sapiens_hsa045100.36384945
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35896820
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34719729
144HIF-1 signaling pathway_Homo sapiens_hsa040660.34130043

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