PLD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.36309666
2positive regulation of cellular amide metabolic process (GO:0034250)5.13927607
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87384604
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.87384604
5modulation by symbiont of host immune response (GO:0052553)4.87384604
6positive regulation by symbiont of host defense response (GO:0052509)4.87384604
7modulation by symbiont of host defense response (GO:0052031)4.87384604
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87384604
9protein localization to endosome (GO:0036010)4.20624281
10microglial cell activation (GO:0001774)3.85080702
11barbed-end actin filament capping (GO:0051016)3.78837852
12macrophage activation involved in immune response (GO:0002281)3.78357527
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56858482
14epithelial cell differentiation involved in prostate gland development (GO:0060742)3.56164210
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43869592
16response to host immune response (GO:0052572)3.43869592
17positive regulation of Cdc42 GTPase activity (GO:0043089)3.41358142
18skin morphogenesis (GO:0043589)3.37836768
19epithelial cell-cell adhesion (GO:0090136)3.22495140
20pinocytosis (GO:0006907)3.21533267
21response to host (GO:0075136)3.20532219
22response to host defenses (GO:0052200)3.20532219
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.20532219
24apoptotic cell clearance (GO:0043277)3.19878928
25endothelial cell chemotaxis (GO:0035767)3.19854111
26mannose metabolic process (GO:0006013)3.19671135
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18978273
28positive regulation of heat generation (GO:0031652)3.10735433
29regulation of water loss via skin (GO:0033561)3.10710307
30regulation of interferon-beta biosynthetic process (GO:0045357)3.07813079
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.05945600
32cell-substrate junction assembly (GO:0007044)3.04776917
33adherens junction assembly (GO:0034333)3.02874792
34cell adhesion mediated by integrin (GO:0033627)2.92617711
35regulation of integrin activation (GO:0033623)2.91229375
36response to laminar fluid shear stress (GO:0034616)2.88890502
37negative regulation of erythrocyte differentiation (GO:0045647)2.87490179
38surfactant homeostasis (GO:0043129)2.85819945
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84614742
40negative regulation of chondrocyte differentiation (GO:0032331)2.84089942
41detection of molecule of bacterial origin (GO:0032490)2.83013549
42response to muramyl dipeptide (GO:0032495)2.83012154
43basement membrane organization (GO:0071711)2.82414799
44I-kappaB phosphorylation (GO:0007252)2.81576515
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78471710
46macrophage activation (GO:0042116)2.78229363
47regulation of vitamin D biosynthetic process (GO:0060556)2.78226951
48cell-cell junction maintenance (GO:0045217)2.77791737
49establishment of skin barrier (GO:0061436)2.75866936
50L-amino acid import (GO:0043092)2.74266679
51apoptotic process involved in morphogenesis (GO:0060561)2.72778539
52regulation of early endosome to late endosome transport (GO:2000641)2.71775846
53glycosphingolipid catabolic process (GO:0046479)2.70826846
54cell-substrate adherens junction assembly (GO:0007045)2.64209881
55focal adhesion assembly (GO:0048041)2.64209881
56bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62753131
57detection of other organism (GO:0098543)2.60721803
58keratinization (GO:0031424)2.60512422
59positive regulation of extracellular matrix organization (GO:1903055)2.59118275
60decidualization (GO:0046697)2.53168005
61detection of bacterium (GO:0016045)2.52799683
62atrioventricular valve morphogenesis (GO:0003181)2.52376796
63cell migration involved in heart development (GO:0060973)2.51499365
64positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51233301
65amino acid import (GO:0043090)2.50163934
66regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49650981
67regulation of plasminogen activation (GO:0010755)2.49579310
68wound healing, spreading of epidermal cells (GO:0035313)2.49268200
69regulation of heat generation (GO:0031650)2.49161663
70semaphorin-plexin signaling pathway (GO:0071526)2.49158743
71tooth mineralization (GO:0034505)2.48354312
72negative regulation of blood vessel endothelial cell migration (GO:0043537)2.48033925
73regulation of cholesterol homeostasis (GO:2000188)2.47516965
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47077690
75regulation of apoptotic cell clearance (GO:2000425)2.44828819
76positive regulation of receptor recycling (GO:0001921)2.43263461
77regulation of podosome assembly (GO:0071801)2.43251647
78response to peptidoglycan (GO:0032494)2.42094511
79endodermal cell differentiation (GO:0035987)2.40887782
80positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40687338
81cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40685815
82branching involved in salivary gland morphogenesis (GO:0060445)2.40507072
83embryonic process involved in female pregnancy (GO:0060136)2.40274089
84hemidesmosome assembly (GO:0031581)2.39022084
85regulation of extracellular matrix disassembly (GO:0010715)2.36450741
86vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36298974
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.35903443
88negative regulation of cell size (GO:0045792)2.35609663
89regulation of tight junction assembly (GO:2000810)2.35513907
90negative regulation of keratinocyte proliferation (GO:0010839)2.35276389
91glycolipid catabolic process (GO:0019377)2.35129491
92positive regulation of p38MAPK cascade (GO:1900745)2.34523018
93regulation of mononuclear cell migration (GO:0071675)2.34325685
94regulation of superoxide anion generation (GO:0032928)2.33900598
95substrate-dependent cell migration (GO:0006929)2.31837425
96regulation of macrophage chemotaxis (GO:0010758)2.31765970
97regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.31486086
98amino sugar catabolic process (GO:0046348)2.31434041
99Golgi transport vesicle coating (GO:0048200)2.31113067
100COPI coating of Golgi vesicle (GO:0048205)2.31113067
101embryo implantation (GO:0007566)2.30955033
102positive regulation of antigen processing and presentation (GO:0002579)2.30166649
103negative regulation of lipid storage (GO:0010888)2.29745377
104NIK/NF-kappaB signaling (GO:0038061)2.29733430
105superoxide anion generation (GO:0042554)2.29370782
106regulation of extracellular matrix organization (GO:1903053)2.29147831
107positive regulation of interferon-alpha production (GO:0032727)2.28954581
108negative regulation of cartilage development (GO:0061037)2.28879934
109cellular response to thyroid hormone stimulus (GO:0097067)2.28855821
110virion attachment to host cell (GO:0019062)2.26993204
111adhesion of symbiont to host cell (GO:0044650)2.26993204
112protein retention in ER lumen (GO:0006621)2.26610916
113regulation of lipid kinase activity (GO:0043550)2.26440591
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26057147
115negative regulation of catenin import into nucleus (GO:0035414)2.25894198
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25776851
117positive regulation of fat cell differentiation (GO:0045600)2.23949012
118glial cell proliferation (GO:0014009)2.23368569
119axon extension involved in axon guidance (GO:0048846)2.22289810
120neuron projection extension involved in neuron projection guidance (GO:1902284)2.22289810
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20745385
122regulation of phospholipid biosynthetic process (GO:0071071)2.20083515
123neutrophil activation involved in immune response (GO:0002283)2.19161133
124positive regulation of interleukin-1 beta secretion (GO:0050718)2.19076447
125negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.17800721
126response to lipoprotein particle (GO:0055094)2.16868061
127myeloid cell activation involved in immune response (GO:0002275)2.12302120
128negative regulation of homotypic cell-cell adhesion (GO:0034111)2.12231959
129positive regulation of cholesterol efflux (GO:0010875)2.11942117
130regulation of interferon-alpha production (GO:0032647)2.11731138
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.11625200
132regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.11201457
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.11037656
134cytokine secretion (GO:0050663)2.08979320
135regulation of cellular amide metabolic process (GO:0034248)2.08625340
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.08033464
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07647006
138vascular endothelial growth factor signaling pathway (GO:0038084)2.07132318
139regulation of beta-amyloid formation (GO:1902003)2.06282344
140positive regulation of macrophage cytokine production (GO:0060907)2.05586401
141detection of biotic stimulus (GO:0009595)2.05122332
142regulation of macrophage cytokine production (GO:0010935)2.03398808
143regulation of fever generation (GO:0031620)2.03229501
144response to auditory stimulus (GO:0010996)2.01671253
145regulation of cholesterol storage (GO:0010885)1.99258412
146adhesion of symbiont to host (GO:0044406)1.98440425
147wound healing, spreading of cells (GO:0044319)1.98353951
148germinal center formation (GO:0002467)1.97520325
149positive regulation of interleukin-1 secretion (GO:0050716)1.97510432
150detection of external biotic stimulus (GO:0098581)1.96931777
151regulation of alkaline phosphatase activity (GO:0010692)1.94945693
152positive regulation of chemokine biosynthetic process (GO:0045080)1.94241013
153ganglion development (GO:0061548)1.93529556
154stress fiber assembly (GO:0043149)1.93251212
155regulation of interleukin-1 beta secretion (GO:0050706)1.92167203
156platelet-derived growth factor receptor signaling pathway (GO:0048008)1.91037046
157modulation by symbiont of host cellular process (GO:0044068)1.87811938
158granulocyte activation (GO:0036230)1.87348897
159regulation of platelet aggregation (GO:0090330)1.86844388
160regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.86341597
161ovulation cycle (GO:0042698)1.86260628
162protein kinase C signaling (GO:0070528)1.86085084
163ruffle organization (GO:0031529)1.85255330
164regulation of antigen processing and presentation (GO:0002577)1.84982804
165positive regulation of interleukin-1 beta production (GO:0032731)1.84759504
166negative regulation of granulocyte differentiation (GO:0030853)1.84623766
167positive regulation of interleukin-8 biosynthetic process (GO:0045416)1.84314002
168chondroitin sulfate catabolic process (GO:0030207)1.83699564
169response to cholesterol (GO:0070723)1.83513989
170regulation of interleukin-1 secretion (GO:0050704)1.82790369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1LXR_22292898_ChIP-Seq_THP-1_Human2.63891490
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.63559945
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60610097
4ELK3_25401928_ChIP-Seq_HUVEC_Human2.56918601
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38270673
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.36260068
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.36095779
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15913819
9RACK7_27058665_Chip-Seq_MCF-7_Human2.14430404
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08379584
11BP1_19119308_ChIP-ChIP_Hs578T_Human1.97570799
12IRF8_27001747_Chip-Seq_BMDM_Mouse1.97000476
13ZNF263_19887448_ChIP-Seq_K562_Human1.91408104
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91371907
15VDR_21846776_ChIP-Seq_THP-1_Human1.90899228
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87680881
17CLOCK_20551151_ChIP-Seq_293T_Human1.85481097
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84655318
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84326287
20TCF7_22412390_ChIP-Seq_EML_Mouse1.80227382
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.77371482
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75449052
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74795415
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74689958
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70907422
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66414096
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.64831392
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.64651788
29GBX2_23144817_ChIP-Seq_PC3_Human1.64454986
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64106780
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63320695
32KDM2B_26808549_Chip-Seq_DND41_Human1.62137715
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.62053833
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61799034
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.60671160
36MYC_22102868_ChIP-Seq_BL_Human1.60440338
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58746340
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56985346
39DROSHA_22980978_ChIP-Seq_HELA_Human1.56437818
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56247973
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.55171502
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54927899
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54039466
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53810647
45VDR_24787735_ChIP-Seq_THP-1_Human1.52406124
46TP53_16413492_ChIP-PET_HCT116_Human1.51073476
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48767447
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48685925
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45822669
50AR_21572438_ChIP-Seq_LNCaP_Human1.45799818
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45333606
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.43480696
53* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43468449
54CJUN_26792858_Chip-Seq_BT549_Human1.43178152
55RXR_22108803_ChIP-Seq_LS180_Human1.41119437
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39610037
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34632848
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34432455
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32944580
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31941716
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31514282
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30969701
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30441178
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29132200
65SMC4_20622854_ChIP-Seq_HELA_Human1.28813777
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28706255
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28279503
68ATF3_27146783_Chip-Seq_COLON_Human1.27763639
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26935176
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.26743407
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26380428
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25251172
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24787565
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24782582
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24120264
76P68_20966046_ChIP-Seq_HELA_Human1.23991693
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23082786
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22852985
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21592334
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21592334
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21295006
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21295006
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21295006
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21291178
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20821576
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20821576
87TP53_22127205_ChIP-Seq_IMR90_Human1.20753241
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20680636
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20581609
90AHR_22903824_ChIP-Seq_MCF-7_Human1.20425792
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19632269
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.19199889
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18297311
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18122723
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.17890408
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17486803
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17305814
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16765447
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.16663381
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16296193
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.16072674
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15815419
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.14896511
104VDR_24763502_ChIP-Seq_THP-1_Human1.14714373
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14470550
106TP53_18474530_ChIP-ChIP_U2OS_Human1.14063745
107RXR_22158963_ChIP-Seq_LIVER_Mouse1.13915300
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13807611
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13183108
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.13022652
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12821085
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12636468
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12026939
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11430179
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11264419
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10170904
117SPI1_23127762_ChIP-Seq_K562_Human1.09975052
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09804304
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09360457
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09346928
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09079534
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08788885
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.08475794
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.08045523
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07952202
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.07170075
127TP63_22573176_ChIP-Seq_HFKS_Human1.06987966
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06708438
129* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06286759
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.06079313
131SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05400144
132JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04871893
133RUNX1_22412390_ChIP-Seq_EML_Mouse1.04731686
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.04613776
135RNF2_27304074_Chip-Seq_ESCs_Mouse1.04352452
136CREB1_26743006_Chip-Seq_LNCaP_Human1.04076843
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03774769
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02839974
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02839974
140BCOR_27268052_Chip-Seq_Bcells_Human1.02311693
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02311130
142STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01877629
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01460333
144CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01108362
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01027388
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00891841
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99704296
148RUNX_20019798_ChIP-Seq_JUKART_Human0.98915252
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98890970
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98480849
151NCOR1_26117541_ChIP-Seq_K562_Human0.98315142
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97969060
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97081808
154SOX2_20726797_ChIP-Seq_SW620_Human0.95726530
155TP63_23658742_ChIP-Seq_EP156T_Human0.94768068
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94374992
157STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93711573
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93256607
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89682961
160KLF5_25053715_ChIP-Seq_YYC3_Human0.88608400
161STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86838257
162CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86512731
163SMAD4_21799915_ChIP-Seq_A2780_Human0.86328513
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86207216
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86103818
166KDM2B_26808549_Chip-Seq_K562_Human0.85441888
167SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84630690
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84215406
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83683013
170EZH2_27294783_Chip-Seq_ESCs_Mouse0.82685948
171JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82169059
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.81013742
173NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80872295
174P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79945662
175SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79471545
176FOXA2_19822575_ChIP-Seq_HepG2_Human0.78936057
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78665370
178SMAD4_21741376_ChIP-Seq_HESCs_Human0.78446970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.28983608
2MP0005058_abnormal_lysosome_morphology3.55578235
3MP0002254_reproductive_system_inflammat3.20906895
4MP0004510_myositis2.87318266
5MP0003172_abnormal_lysosome_physiology2.86650785
6MP0008438_abnormal_cutaneous_collagen2.79457807
7MP0001849_ear_inflammation2.59561710
8MP0005257_abnormal_intraocular_pressure2.58347582
9MP0001958_emphysema2.39444727
10MP0010234_abnormal_vibrissa_follicle2.34684345
11MP0003690_abnormal_glial_cell2.30244539
12MP0004858_abnormal_nervous_system2.27810787
13MP0008260_abnormal_autophagy2.23719371
14MP0003705_abnormal_hypodermis_morpholog2.15787450
15MP0003303_peritoneal_inflammation2.09495959
16MP0005076_abnormal_cell_differentiation2.04342813
17MP0003566_abnormal_cell_adhesion2.03730693
18MP0002419_abnormal_innate_immunity1.96316442
19MP0001835_abnormal_antigen_presentation1.95159652
20MP0003075_altered_response_to1.90517217
21MP0005023_abnormal_wound_healing1.90226203
22MP0005275_abnormal_skin_tensile1.87387232
23MP0005167_abnormal_blood-brain_barrier1.86846866
24MP0000604_amyloidosis1.84892556
25MP0004947_skin_inflammation1.84205790
26MP0003091_abnormal_cell_migration1.81798801
27MP0010030_abnormal_orbit_morphology1.77187058
28MP0003300_gastrointestinal_ulcer1.76483076
29MP0002998_abnormal_bone_remodeling1.66908869
30MP0003045_fibrosis1.64395764
31MP0005501_abnormal_skin_physiology1.63581473
32MP0003941_abnormal_skin_development1.61660841
33MP0004264_abnormal_extraembryonic_tissu1.59635121
34MP0009840_abnormal_foam_cell1.59573828
35MP0001216_abnormal_epidermal_layer1.54059664
36MP0003279_aneurysm1.51963524
37MP0005409_darkened_coat_color1.50868403
38MP0000858_altered_metastatic_potential1.49424487
39MP0006082_CNS_inflammation1.46871846
40MP0000566_synostosis1.46503404
41MP0003436_decreased_susceptibility_to1.44820506
42MP0003183_abnormal_peptide_metabolism1.41896324
43MP0004130_abnormal_muscle_cell1.39273945
44MP0003448_altered_tumor_morphology1.37222645
45MP0001533_abnormal_skeleton_physiology1.36245368
46MP0003646_muscle_fatigue1.36178455
47MP0009764_decreased_sensitivity_to1.35545711
48MP0000767_abnormal_smooth_muscle1.35137725
49MP0003724_increased_susceptibility_to1.33801346
50MP0000467_abnormal_esophagus_morphology1.32704059
51MP0003191_abnormal_cellular_cholesterol1.32566698
52MP0001790_abnormal_immune_system1.32432414
53MP0005387_immune_system_phenotype1.32432414
54MP0000343_altered_response_to1.31788679
55MP0009278_abnormal_bone_marrow1.30864641
56MP0002148_abnormal_hypersensitivity_rea1.28617678
57MP0000383_abnormal_hair_follicle1.24388155
58MP0005464_abnormal_platelet_physiology1.23518845
59MP0001851_eye_inflammation1.22288453
60MP0005377_hearing/vestibular/ear_phenot1.22003642
61MP0003878_abnormal_ear_physiology1.22003642
62MP0005310_abnormal_salivary_gland1.21832982
63MP0005025_abnormal_response_to1.21110146
64MP0005166_decreased_susceptibility_to1.20766512
65MP0004859_abnormal_synaptic_plasticity1.18666366
66MP0004185_abnormal_adipocyte_glucose1.17774651
67MP0005000_abnormal_immune_tolerance1.17555932
68MP0002452_abnormal_antigen_presenting1.16425598
69MP0002295_abnormal_pulmonary_circulatio1.16007355
70MP0009785_altered_susceptibility_to1.15005973
71MP0009053_abnormal_anal_canal1.14588869
72MP0000579_abnormal_nail_morphology1.13852176
73MP0002060_abnormal_skin_morphology1.13453824
74MP0002098_abnormal_vibrissa_morphology1.10757893
75MP0003453_abnormal_keratinocyte_physiol1.09263566
76MP0000762_abnormal_tongue_morphology1.09059132
77MP0002090_abnormal_vision1.08924601
78MP0010352_gastrointestinal_tract_polyps1.06594158
79MP0002089_abnormal_postnatal_growth/wei1.03940422
80MP0002896_abnormal_bone_mineralization1.03401048
81MP0009384_cardiac_valve_regurgitation1.01530744
82MP0010678_abnormal_skin_adnexa0.99913723
83MP0008004_abnormal_stomach_pH0.99546587
84MP0005174_abnormal_tail_pigmentation0.99439425
85MP0010368_abnormal_lymphatic_system0.98485327
86MP0004233_abnormal_muscle_weight0.95627157
87MP0001915_intracranial_hemorrhage0.94687870
88MP0002168_other_aberrant_phenotype0.94493258
89MP0001879_abnormal_lymphatic_vessel0.94299533
90MP0000377_abnormal_hair_follicle0.93662915
91MP0001853_heart_inflammation0.93263754
92MP0002877_abnormal_melanocyte_morpholog0.92365661
93MP0005666_abnormal_adipose_tissue0.91317152
94MP0002332_abnormal_exercise_endurance0.91029265
95MP0004272_abnormal_basement_membrane0.90794829
96MP0000733_abnormal_muscle_development0.90555814
97MP0006054_spinal_hemorrhage0.90434104
98MP0000015_abnormal_ear_pigmentation0.90096686
99MP0010771_integument_phenotype0.89785469
100MP0005390_skeleton_phenotype0.89722438
101MP0001501_abnormal_sleep_pattern0.89512216
102MP0009931_abnormal_skin_appearance0.88532379
103MP0002006_tumorigenesis0.88511369
104MP0002723_abnormal_immune_serum0.88393146
105MP0003828_pulmonary_edema0.88109465
106MP0003634_abnormal_glial_cell0.85586976
107MP0000678_abnormal_parathyroid_gland0.85474921
108MP0003329_amyloid_beta_deposits0.82619113
109MP0005375_adipose_tissue_phenotype0.82293180
110MP0005388_respiratory_system_phenotype0.81523200
111MP0002133_abnormal_respiratory_system0.81523200
112MP0001243_abnormal_dermal_layer0.81468873
113MP0000003_abnormal_adipose_tissue0.80860328
114MP0000685_abnormal_immune_system0.79480939
115MP0002138_abnormal_hepatobiliary_system0.79168025
116MP0005595_abnormal_vascular_smooth0.78388301
117MP0001800_abnormal_humoral_immune0.77969789
118MP0005197_abnormal_uvea_morphology0.77570546
119MP0005508_abnormal_skeleton_morphology0.76689030
120MP0005451_abnormal_body_composition0.76344204
121MP0001819_abnormal_immune_cell0.73921524
122MP0001299_abnormal_eye_distance/0.73038946
123MP0001502_abnormal_circadian_rhythm0.71955160
124MP0009672_abnormal_birth_weight0.71188814
125MP0009780_abnormal_chondrocyte_physiolo0.71074500
126MP0005164_abnormal_response_to0.70972988
127MP0010386_abnormal_urinary_bladder0.70912560
128MP0000249_abnormal_blood_vessel0.70461471
129MP0002420_abnormal_adaptive_immunity0.70411708
130MP0001614_abnormal_blood_vessel0.70377699
131MP0001348_abnormal_lacrimal_gland0.69409844
132MP0004782_abnormal_surfactant_physiolog0.69370084
133MP0000751_myopathy0.68698913
134MP0005670_abnormal_white_adipose0.68577615
135MP0000647_abnormal_sebaceous_gland0.68113631
136MP0000537_abnormal_urethra_morphology0.67816755
137MP0000371_diluted_coat_color0.67551744
138MP0002796_impaired_skin_barrier0.67082194
139MP0009333_abnormal_splenocyte_physiolog0.66586728
140MP0000920_abnormal_myelination0.66510396
141MP0002933_joint_inflammation0.65338080

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.75355919
2Thick nail (HP:0001805)3.68166315
3Recurrent bacterial skin infections (HP:0005406)3.48863441
4Increased cerebral lipofuscin (HP:0011813)3.23451108
5Eczematoid dermatitis (HP:0000976)3.17761042
6Cervical subluxation (HP:0003308)3.09847027
7Abnormality of liposaccharide metabolism (HP:0010968)3.09019114
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.09019114
9Abnormality of glycolipid metabolism (HP:0010969)3.09019114
10Abnormality of nail color (HP:0100643)3.03792519
11Cerebral aneurysm (HP:0004944)2.99202143
12Axonal loss (HP:0003447)2.98302234
13Aplasia involving bones of the extremities (HP:0009825)2.97265689
14Aplasia involving bones of the upper limbs (HP:0009823)2.97265689
15Aplasia of the phalanges of the hand (HP:0009802)2.97265689
16Broad metatarsal (HP:0001783)2.94706539
17Pulmonary artery stenosis (HP:0004415)2.86286369
18Shallow orbits (HP:0000586)2.80581520
19Gingivitis (HP:0000230)2.66386638
20Nuclear cataract (HP:0100018)2.63712640
21Systemic lupus erythematosus (HP:0002725)2.61351386
22Broad face (HP:0000283)2.60892640
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.59661102
24Vacuolated lymphocytes (HP:0001922)2.58649720
25Premature rupture of membranes (HP:0001788)2.57329316
26Atrophic scars (HP:0001075)2.57132147
27Periodontitis (HP:0000704)2.56156751
28Arterial tortuosity (HP:0005116)2.53089484
29Alopecia of scalp (HP:0002293)2.51892524
30Hematochezia (HP:0002573)2.51143533
31Recurrent gram-negative bacterial infections (HP:0005420)2.48954775
32Polygenic inheritance (HP:0010982)2.48098077
33Turricephaly (HP:0000262)2.45153418
34Abnormality of macrophages (HP:0004311)2.43106890
35Increased IgE level (HP:0003212)2.42297789
36Absent frontal sinuses (HP:0002688)2.38821086
37Vascular tortuosity (HP:0004948)2.36791890
38Myocardial infarction (HP:0001658)2.35950625
39Distal lower limb amyotrophy (HP:0008944)2.34313887
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.33076494
41Osteolytic defects of the hand bones (HP:0009699)2.33076494
42Hyperacusis (HP:0010780)2.31550019
43Flat acetabular roof (HP:0003180)2.31482924
44Aortic dissection (HP:0002647)2.31254584
45Biconcave vertebral bodies (HP:0004586)2.30959826
46Natal tooth (HP:0000695)2.30114784
47Autoimmune thrombocytopenia (HP:0001973)2.29205057
48Tetraparesis (HP:0002273)2.28763714
49Obstructive sleep apnea (HP:0002870)2.27599973
50Spontaneous hematomas (HP:0007420)2.27319837
51Thin bony cortex (HP:0002753)2.25957870
52Increased connective tissue (HP:0009025)2.23614768
53Amyloidosis (HP:0011034)2.22442724
54Disproportionate tall stature (HP:0001519)2.18825418
55Dysostosis multiplex (HP:0000943)2.18117065
56Abnormality of polysaccharide metabolism (HP:0011012)2.17725758
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17725758
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17725758
59Orchitis (HP:0100796)2.15981717
60Aortic aneurysm (HP:0004942)2.14989485
61Follicular hyperkeratosis (HP:0007502)2.13358994
62Lower limb amyotrophy (HP:0007210)2.12151702
63Spondylolisthesis (HP:0003302)2.11774289
64Selective tooth agenesis (HP:0001592)2.10537985
65Premature loss of primary teeth (HP:0006323)2.07494132
66Advanced eruption of teeth (HP:0006288)2.05130631
67Abnormality of complement system (HP:0005339)2.02288738
68Blue sclerae (HP:0000592)2.01772196
69Recurrent skin infections (HP:0001581)2.01030778
70Neurofibrillary tangles (HP:0002185)1.98625283
71Distal lower limb muscle weakness (HP:0009053)1.98420133
72Abnormality of the salivary glands (HP:0010286)1.97896257
73Short nail (HP:0001799)1.97464458
74Prostate neoplasm (HP:0100787)1.96680110
75Malnutrition (HP:0004395)1.96548051
76Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.95737056
77Cerebral inclusion bodies (HP:0100314)1.93035051
78Stomatitis (HP:0010280)1.91909165
79Mediastinal lymphadenopathy (HP:0100721)1.91904645
80Frequent falls (HP:0002359)1.91248697
81Megalencephaly (HP:0001355)1.91117600
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89858728
83Fragile nails (HP:0001808)1.89704166
84Milia (HP:0001056)1.89245244
85Optic neuritis (HP:0100653)1.88368324
86Retrobulbar optic neuritis (HP:0100654)1.88368324
87Abnormality of the frontal sinuses (HP:0002687)1.88180056
88Mitral valve prolapse (HP:0001634)1.86908625
89Mitral regurgitation (HP:0001653)1.86396134
90Nail dystrophy (HP:0008404)1.85095429
91Palmar hyperkeratosis (HP:0010765)1.82168876
92Supranuclear gaze palsy (HP:0000605)1.80850045
93Upper motor neuron abnormality (HP:0002127)1.80480287
94Abnormality of the distal phalanges of the toes (HP:0010182)1.78619282
95Bell-shaped thorax (HP:0001591)1.78489927
96Mucopolysacchariduria (HP:0008155)1.78465795
97Urinary glycosaminoglycan excretion (HP:0003541)1.78465795
98Complement deficiency (HP:0004431)1.78373103
99Vertebral compression fractures (HP:0002953)1.77836099
100Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77214593
101Elevated erythrocyte sedimentation rate (HP:0003565)1.76333398
102Peritonitis (HP:0002586)1.75576150
103Genu recurvatum (HP:0002816)1.74904571
104Spinal rigidity (HP:0003306)1.74846223
105Syringomyelia (HP:0003396)1.74341006
106Spinal cord lesions (HP:0100561)1.74341006
107Achilles tendon contracture (HP:0001771)1.73754830
108Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73065223
109Bone pain (HP:0002653)1.71758611
110Myositis (HP:0100614)1.71703356
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71609952
112Type 1 muscle fiber predominance (HP:0003803)1.71131945
113Dilatation of the ascending aorta (HP:0005111)1.70358949
114Nephritis (HP:0000123)1.69428377
115Abnormal ossification of hand bones (HP:0005921)1.69139733
116Peripheral demyelination (HP:0011096)1.68528416
117Aneurysm (HP:0002617)1.68495977
118Glomerulonephritis (HP:0000099)1.68359035
119Neuronal loss in central nervous system (HP:0002529)1.68017460
120Ulnar bowing (HP:0003031)1.67674009
121Segmental peripheral demyelination/remyelination (HP:0003481)1.67235996
122Protrusio acetabuli (HP:0003179)1.66839961
123Abnormality of the lumbar spine (HP:0100712)1.66826240
124Esophageal varix (HP:0002040)1.66716203
125Elevated alkaline phosphatase (HP:0003155)1.66604686
126Interstitial pulmonary disease (HP:0006530)1.66466424
127Right ventricular cardiomyopathy (HP:0011663)1.66387086
128Loss of speech (HP:0002371)1.66074854
129Deep venous thrombosis (HP:0002625)1.65602608
130Fragile skin (HP:0001030)1.64997914
131Difficulty climbing stairs (HP:0003551)1.64700758
132Short hallux (HP:0010109)1.64414815
133Conjunctival telangiectasia (HP:0000524)1.64223113
134Joint stiffness (HP:0001387)1.64124844
135Plantar hyperkeratosis (HP:0007556)1.63581999
136Thoracic kyphosis (HP:0002942)1.62653322
137Scapular winging (HP:0003691)1.62633645
138Long palpebral fissure (HP:0000637)1.61986231
139Palmoplantar hyperkeratosis (HP:0000972)1.61688904
140Mixed hearing impairment (HP:0000410)1.61421227
141Craniofacial hyperostosis (HP:0004493)1.61020196
142Hemangiomatosis (HP:0007461)1.60966595
143Abnormality of carpal bone ossification (HP:0006257)1.60688692
144Metaphyseal cupping (HP:0003021)1.60600405
145Abnormality of proline metabolism (HP:0010907)1.59286520
146Hydroxyprolinuria (HP:0003080)1.59286520
147J-shaped sella turcica (HP:0002680)1.57712521
148Adactyly (HP:0009776)1.56848504
149Long toe (HP:0010511)1.56708277
150Bronchomalacia (HP:0002780)1.56356704
151Arterial thrombosis (HP:0004420)1.55507427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.14196488
2MAP3K132.64526769
3MAP3K142.62875494
4IRAK32.55685055
5SIK12.46207173
6TTN2.45789395
7LMTK22.36655196
8RIPK42.30119846
9MAP3K32.28822801
10EPHA22.20388533
11CAMK1D2.20001780
12NME22.12830024
13MAP2K32.04973343
14JAK11.98731307
15TYK21.93086029
16DMPK1.88207427
17TGFBR21.86015821
18PAK41.84257836
19CAMK1G1.80391074
20LATS11.75324621
21EEF2K1.74056611
22RIPK11.73296776
23KIT1.65820457
24TBK11.62587047
25ICK1.61353796
26TRIB31.57602508
27CDC42BPA1.57140806
28MST1R1.56915090
29EPHA41.45729118
30SIK21.44947325
31IKBKE1.43365495
32CDK121.42980566
33TYRO31.39048073
34EPHB11.38346558
35BMX1.37401569
36MAP3K111.33489750
37BLK1.31040415
38PHKG21.30912278
39PHKG11.30912278
40PRKD21.26066582
41KSR21.23894328
42NTRK21.21052562
43MET1.20036624
44TAOK31.17882668
45PAK61.16701486
46IKBKB1.14675601
47SGK31.13140712
48TRPM71.10171531
49TESK11.09320346
50DAPK21.07397847
51FES1.06812374
52MAP4K11.05308692
53DDR21.05160479
54NEK91.04108452
55MTOR1.03825096
56SGK21.00555417
57PTK61.00063919
58STK380.98634272
59IRAK40.98238573
60MATK0.97958524
61MAP3K90.95944760
62MAP3K10.94167030
63HCK0.93685562
64NTRK10.92602935
65PRKAA20.91662369
66MAP3K70.91197205
67PRKD30.90606857
68PDGFRA0.90573346
69PDGFRB0.87308424
70ZAP700.86782596
71STK30.86580302
72ARAF0.85677176
73CSF1R0.83785045
74MOS0.83750801
75CHUK0.83451897
76JAK20.80743714
77PRKCH0.78085196
78MAP3K20.77907031
79MUSK0.76850683
80MAPK120.76742679
81PTK20.76632345
82FGFR30.75770732
83TNIK0.75743986
84NUAK10.75581676
85PRKG20.75056791
86MARK30.74607596
87ERN10.74202275
88SGK10.73906523
89CDK90.73047539
90RPS6KL10.71786070
91RPS6KC10.71786070
92PTK2B0.71545851
93ERBB40.71025667
94LRRK20.68313387
95CSK0.67349219
96PRKCE0.66783881
97TIE10.65367537
98PKN20.64736859
99EPHB20.63234411
100MAP3K60.61062345
101FER0.60133792
102MAP3K80.59467850
103ROCK10.58723688
104STK100.58553907
105MELK0.58408582
106PIK3CA0.58266606
107PKN10.58035690
108KDR0.57735309
109CAMKK10.57398417
110SGK2230.57311975
111SGK4940.57311975
112IRAK20.56879277
113PDPK10.54830864
114RET0.54420628
115EPHA30.53939180
116ABL10.52547128
117TAOK10.51682947
118* FGR0.51306093
119MAPK150.51029448
120PRPF4B0.50462092
121RPS6KA40.49477357
122DYRK1B0.48809641
123CDK40.47647033
124RPS6KA60.46945231
125MARK20.46689542
126RPS6KA10.44658697
127TAOK20.43974223
128MAPKAPK30.43359783
129FGFR40.42832221
130* JAK30.42678932
131CDK60.42058820
132RPS6KB20.41004352
133LATS20.40983284
134MAP3K100.40653627
135MAPKAPK20.40603290
136IGF1R0.40357207
137MAP2K20.40220745
138RPS6KA20.40172556
139* SRC0.39616703
140SIK30.38576039
141TGFBR10.38063231
142PIM20.37805990
143CAMK40.37665328
144PRKD10.37619063
145NEK60.36859758
146INSR0.36454128
147ABL20.36393391
148MAPK70.36365308
149MAP2K10.35925926

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06284179
2Staphylococcus aureus infection_Homo sapiens_hsa051501.91030761
3Prion diseases_Homo sapiens_hsa050201.84456237
4Galactose metabolism_Homo sapiens_hsa000521.82478463
5Malaria_Homo sapiens_hsa051441.77723692
6Osteoclast differentiation_Homo sapiens_hsa043801.70262592
7Lysosome_Homo sapiens_hsa041421.64279828
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63949292
9Bladder cancer_Homo sapiens_hsa052191.63929754
10Leishmaniasis_Homo sapiens_hsa051401.62608601
11TNF signaling pathway_Homo sapiens_hsa046681.47527028
12Other glycan degradation_Homo sapiens_hsa005111.42304230
13Tuberculosis_Homo sapiens_hsa051521.41107543
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.40284378
15Acute myeloid leukemia_Homo sapiens_hsa052211.34895319
16Pertussis_Homo sapiens_hsa051331.33160924
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29969161
18Fatty acid biosynthesis_Homo sapiens_hsa000611.27837694
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27625654
20ECM-receptor interaction_Homo sapiens_hsa045121.22819507
21Rheumatoid arthritis_Homo sapiens_hsa053231.22052289
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.21172604
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.21063463
24Amoebiasis_Homo sapiens_hsa051461.19898001
25Toxoplasmosis_Homo sapiens_hsa051451.18842010
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14792248
27* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11607264
28Phagosome_Homo sapiens_hsa041451.09764729
29Vibrio cholerae infection_Homo sapiens_hsa051101.08205713
30Focal adhesion_Homo sapiens_hsa045101.06180383
31Dilated cardiomyopathy_Homo sapiens_hsa054141.03958136
32Salmonella infection_Homo sapiens_hsa051321.03400733
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02473743
34Chemokine signaling pathway_Homo sapiens_hsa040621.01743956
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01459614
36Adipocytokine signaling pathway_Homo sapiens_hsa049200.99669957
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99581580
38Influenza A_Homo sapiens_hsa051640.98222697
39African trypanosomiasis_Homo sapiens_hsa051430.97784976
40Dorso-ventral axis formation_Homo sapiens_hsa043200.97474181
41Thyroid cancer_Homo sapiens_hsa052160.96379322
42B cell receptor signaling pathway_Homo sapiens_hsa046620.96353157
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96315536
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94281603
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93329789
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93205564
47Fructose and mannose metabolism_Homo sapiens_hsa000510.92415040
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92357322
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.90119860
50Pentose phosphate pathway_Homo sapiens_hsa000300.89011376
51Proteoglycans in cancer_Homo sapiens_hsa052050.88585967
52Endometrial cancer_Homo sapiens_hsa052130.87238732
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86988729
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86307903
55Pancreatic cancer_Homo sapiens_hsa052120.85915125
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82640732
57Type II diabetes mellitus_Homo sapiens_hsa049300.82397735
58* Phospholipase D signaling pathway_Homo sapiens_hsa040720.81697360
59Platelet activation_Homo sapiens_hsa046110.81159928
60* Endocytosis_Homo sapiens_hsa041440.81137881
61Salivary secretion_Homo sapiens_hsa049700.80439008
62Apoptosis_Homo sapiens_hsa042100.80408878
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79988488
64Hepatitis C_Homo sapiens_hsa051600.78922464
65Sphingolipid metabolism_Homo sapiens_hsa006000.78663873
66Small cell lung cancer_Homo sapiens_hsa052220.78610623
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78092271
68Adherens junction_Homo sapiens_hsa045200.77975898
69Insulin resistance_Homo sapiens_hsa049310.77274291
70Measles_Homo sapiens_hsa051620.77207093
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75887706
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75390045
73Gastric acid secretion_Homo sapiens_hsa049710.75316062
74* Sphingolipid signaling pathway_Homo sapiens_hsa040710.74836413
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74782459
76PPAR signaling pathway_Homo sapiens_hsa033200.74731335
77Shigellosis_Homo sapiens_hsa051310.74146749
78Rap1 signaling pathway_Homo sapiens_hsa040150.73421186
79Nitrogen metabolism_Homo sapiens_hsa009100.73402774
80Renal cell carcinoma_Homo sapiens_hsa052110.73045940
81Estrogen signaling pathway_Homo sapiens_hsa049150.72467071
82* GnRH signaling pathway_Homo sapiens_hsa049120.72383071
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71738274
84Ovarian steroidogenesis_Homo sapiens_hsa049130.71091911
85Chronic myeloid leukemia_Homo sapiens_hsa052200.71061199
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.70615594
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70291930
88Basal cell carcinoma_Homo sapiens_hsa052170.69246022
89Legionellosis_Homo sapiens_hsa051340.68846462
90Complement and coagulation cascades_Homo sapiens_hsa046100.68180453
91ErbB signaling pathway_Homo sapiens_hsa040120.68154509
92Pathways in cancer_Homo sapiens_hsa052000.68031827
93Prostate cancer_Homo sapiens_hsa052150.66861246
94HIF-1 signaling pathway_Homo sapiens_hsa040660.66661068
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.66631285
96Glioma_Homo sapiens_hsa052140.66181238
97Insulin signaling pathway_Homo sapiens_hsa049100.65683378
98Notch signaling pathway_Homo sapiens_hsa043300.65678517
99Graft-versus-host disease_Homo sapiens_hsa053320.65365887
100Renin secretion_Homo sapiens_hsa049240.65282715
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64949217
102Non-small cell lung cancer_Homo sapiens_hsa052230.63659536
103Steroid biosynthesis_Homo sapiens_hsa001000.63324744
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63263474
105Arginine biosynthesis_Homo sapiens_hsa002200.63067532
106Olfactory transduction_Homo sapiens_hsa047400.62360633
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61785123
108Calcium signaling pathway_Homo sapiens_hsa040200.61766902
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.60958655
110MAPK signaling pathway_Homo sapiens_hsa040100.59622392
111* cAMP signaling pathway_Homo sapiens_hsa040240.59525744
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59299811
113Mineral absorption_Homo sapiens_hsa049780.58770961
114Inositol phosphate metabolism_Homo sapiens_hsa005620.58492429
115HTLV-I infection_Homo sapiens_hsa051660.57036296
116* Ras signaling pathway_Homo sapiens_hsa040140.56778605
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56544741
118Hematopoietic cell lineage_Homo sapiens_hsa046400.56324764
119Hepatitis B_Homo sapiens_hsa051610.56252714
120Viral myocarditis_Homo sapiens_hsa054160.55936451
121Morphine addiction_Homo sapiens_hsa050320.55151221
122Prolactin signaling pathway_Homo sapiens_hsa049170.54856816
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54504600
124MicroRNAs in cancer_Homo sapiens_hsa052060.53652338
125Hippo signaling pathway_Homo sapiens_hsa043900.52919937
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52817676
127Oxytocin signaling pathway_Homo sapiens_hsa049210.52789035
128* Choline metabolism in cancer_Homo sapiens_hsa052310.52609632
129Tight junction_Homo sapiens_hsa045300.51945382
130VEGF signaling pathway_Homo sapiens_hsa043700.51734954
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49119419
132Herpes simplex infection_Homo sapiens_hsa051680.45711543
133Histidine metabolism_Homo sapiens_hsa003400.45606336
134Biosynthesis of amino acids_Homo sapiens_hsa012300.43775528
135Axon guidance_Homo sapiens_hsa043600.40632598

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