PLD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.08563538
2positive regulation by symbiont of host defense response (GO:0052509)6.75693392
3modulation by symbiont of host defense response (GO:0052031)6.75693392
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.75693392
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.75693392
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.75693392
7modulation by symbiont of host immune response (GO:0052553)6.75693392
8microglial cell activation (GO:0001774)6.64242625
9macrophage activation involved in immune response (GO:0002281)6.45203555
10regulation of interferon-beta biosynthetic process (GO:0045357)6.22437275
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.89507401
12regulation of B cell receptor signaling pathway (GO:0050855)5.73886016
13neutrophil activation involved in immune response (GO:0002283)5.26783374
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.23317931
15purine deoxyribonucleotide catabolic process (GO:0009155)5.21893945
16negative regulation of B cell apoptotic process (GO:0002903)5.20823633
17positive regulation of interferon-alpha production (GO:0032727)5.01682462
18immunoglobulin mediated immune response (GO:0016064)4.85775011
19regulation of interferon-alpha production (GO:0032647)4.79028613
20G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.69254626
21macrophage activation (GO:0042116)4.66851994
22purinergic nucleotide receptor signaling pathway (GO:0035590)4.59748549
23positive thymic T cell selection (GO:0045059)4.50457322
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.46843354
25positive regulation of B cell differentiation (GO:0045579)4.44550915
26respiratory burst (GO:0045730)4.43819544
27mature B cell differentiation involved in immune response (GO:0002313)4.43647597
28deoxyribonucleotide catabolic process (GO:0009264)4.41079854
29myeloid cell activation involved in immune response (GO:0002275)4.36080011
30regulation of growth of symbiont in host (GO:0044126)4.35116707
31negative regulation of growth of symbiont in host (GO:0044130)4.35116707
32negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.35116707
33modulation of growth of symbiont involved in interaction with host (GO:0044144)4.35116707
34response to peptidoglycan (GO:0032494)4.34622309
35regulation of germinal center formation (GO:0002634)4.29059563
36response to host immune response (GO:0052572)4.24948146
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.24948146
38response to protozoan (GO:0001562)4.24337792
39deoxyribose phosphate catabolic process (GO:0046386)4.21945205
40positive regulation of antigen processing and presentation (GO:0002579)4.19493708
41response to host (GO:0075136)4.12139540
42response to host defenses (GO:0052200)4.12139540
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.12139540
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.07013278
45regulation of B cell differentiation (GO:0045577)3.99429180
46B cell receptor signaling pathway (GO:0050853)3.98643986
47regulation of B cell apoptotic process (GO:0002902)3.94584399
48autophagic vacuole fusion (GO:0000046)3.92520817
49chaperone mediated protein folding requiring cofactor (GO:0051085)3.92360219
50Peyers patch development (GO:0048541)3.85602872
51mucosal-associated lymphoid tissue development (GO:0048537)3.85602872
52adenosine receptor signaling pathway (GO:0001973)3.83255968
53glycosphingolipid catabolic process (GO:0046479)3.81790508
54negative regulation of granulocyte differentiation (GO:0030853)3.72831183
55antigen processing and presentation of endogenous antigen (GO:0019883)3.72403099
56neutrophil activation (GO:0042119)3.71999610
57regulation of mast cell degranulation (GO:0043304)3.71349575
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69432844
59granulocyte activation (GO:0036230)3.67430883
60I-kappaB phosphorylation (GO:0007252)3.65249242
61purinergic receptor signaling pathway (GO:0035587)3.64442015
62deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.63394332
63negative thymic T cell selection (GO:0045060)3.61036649
64response to muramyl dipeptide (GO:0032495)3.60267504
65pinocytosis (GO:0006907)3.59720530
66positive regulation of gamma-delta T cell activation (GO:0046645)3.59341329
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.57985237
68positive regulation of interferon-beta production (GO:0032728)3.54143247
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53979960
70mature B cell differentiation (GO:0002335)3.52270833
71positive regulation of mast cell activation (GO:0033005)3.51616362
72detection of bacterium (GO:0016045)3.50525447
73regulation of antigen processing and presentation (GO:0002577)3.49575628
74regulation of mast cell activation involved in immune response (GO:0033006)3.45931301
75cellular extravasation (GO:0045123)3.44389283
76positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43438503
77purine deoxyribonucleotide metabolic process (GO:0009151)3.42175554
78positive regulation of mast cell degranulation (GO:0043306)3.42035282
79positive regulation of mast cell activation involved in immune response (GO:0033008)3.42035282
80purine nucleotide salvage (GO:0032261)3.41433111
81B cell mediated immunity (GO:0019724)3.40969620
82glycolipid catabolic process (GO:0019377)3.39708629
83purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.39413912
84regulation of mast cell activation (GO:0033003)3.39003184
85lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35480241
86hyaluronan catabolic process (GO:0030214)3.34832678
87detection of other organism (GO:0098543)3.33465097
88myeloid leukocyte activation (GO:0002274)3.32836813
89interferon-gamma-mediated signaling pathway (GO:0060333)3.32459998
90positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.30279542
91negative regulation of myeloid cell apoptotic process (GO:0033033)3.29081422
92negative T cell selection (GO:0043383)3.26993348
93positive regulation of neutrophil migration (GO:1902624)3.26048215
94positive regulation of neutrophil chemotaxis (GO:0090023)3.26048215
95histamine secretion (GO:0001821)3.25761818
96regulation of interleukin-8 biosynthetic process (GO:0045414)3.25243631
97production of molecular mediator involved in inflammatory response (GO:0002532)3.23041673
98positive regulation of macrophage cytokine production (GO:0060907)3.22406870
99regulation of monocyte differentiation (GO:0045655)3.21075985
100cellular response to interferon-beta (GO:0035458)3.20730875
101mast cell activation (GO:0045576)3.20636579
102positive T cell selection (GO:0043368)3.19920507
103pyrimidine nucleotide catabolic process (GO:0006244)3.19893659
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17174368
1052-deoxyribonucleotide metabolic process (GO:0009394)3.15603257
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13607611
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13607611
108regulation of hypersensitivity (GO:0002883)3.13282535
109positive regulation of B cell activation (GO:0050871)3.13110012
110positive regulation of B cell proliferation (GO:0030890)3.12448331
111leukocyte mediated cytotoxicity (GO:0001909)3.11930932
112negative regulation of B cell proliferation (GO:0030889)3.11864400
113positive regulation of monocyte chemotaxis (GO:0090026)3.09653003
114tolerance induction (GO:0002507)3.09204021
115regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08548735
116regulation of leukocyte degranulation (GO:0043300)3.08533022
117deoxyribose phosphate biosynthetic process (GO:0046385)3.08241683
1182-deoxyribonucleotide biosynthetic process (GO:0009265)3.08241683
119deoxyribose phosphate metabolic process (GO:0019692)3.06998229
120ceramide catabolic process (GO:0046514)3.06882523
121regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06860889
122cellular response to exogenous dsRNA (GO:0071360)3.05698100
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03900997
124negative regulation of cell killing (GO:0031342)3.03900997
125negative regulation of mast cell activation (GO:0033004)3.03630351
126establishment of viral latency (GO:0019043)3.02762723
127regulation of monocyte chemotaxis (GO:0090025)3.01317344
128DNA strand elongation involved in DNA replication (GO:0006271)3.01182057
129positive regulation of protein homooligomerization (GO:0032464)2.99509644
130myeloid dendritic cell activation (GO:0001773)2.99028723
131negative regulation of norepinephrine secretion (GO:0010700)2.98621521
132nucleotide salvage (GO:0043173)2.98070198
133cellular response to zinc ion (GO:0071294)2.97130654
134negative regulation of interleukin-6 production (GO:0032715)2.96145258
135macrophage chemotaxis (GO:0048246)2.96047474
136germinal center formation (GO:0002467)2.94957363
137negative regulation of phagocytosis (GO:0050765)2.94053479
138defense response to protozoan (GO:0042832)2.91600288
139positive regulation of chemokine secretion (GO:0090197)2.89520673
140positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.89106872
141type I interferon signaling pathway (GO:0060337)2.86253341
142cellular response to type I interferon (GO:0071357)2.86253341
143response to type I interferon (GO:0034340)2.82809507
144neutrophil mediated immunity (GO:0002446)2.80890764
145positive regulation of cellular amide metabolic process (GO:0034250)2.79371667
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.79287218
147positive regulation of leukocyte degranulation (GO:0043302)2.76933695
148myeloid dendritic cell differentiation (GO:0043011)2.73782806
149natural killer cell mediated cytotoxicity (GO:0042267)2.72686807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse6.90555369
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.36066276
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.92412776
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.90744991
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.47259545
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97496596
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.83185828
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72277833
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47680580
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.29108396
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.22444197
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18209927
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.10262334
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.00606587
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95417706
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.85042897
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66032275
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50802613
19* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46265132
20SCL_19346495_ChIP-Seq_HPC-7_Human2.45815554
21* SPI1_23547873_ChIP-Seq_NB4_Human2.43388871
22CIITA_25753668_ChIP-Seq_RAJI_Human2.31521149
23SPI1_23127762_ChIP-Seq_K562_Human2.27343776
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24768796
25VDR_24763502_ChIP-Seq_THP-1_Human2.21211001
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20715530
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15269211
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12994559
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.10773728
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03672889
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.03480866
32RUNX_20019798_ChIP-Seq_JUKART_Human2.03267962
33VDR_21846776_ChIP-Seq_THP-1_Human2.01889202
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98984963
35GATA1_22025678_ChIP-Seq_K562_Human1.92074205
36MYB_26560356_Chip-Seq_TH2_Human1.90006215
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82496688
38PU_27001747_Chip-Seq_BMDM_Mouse1.78819302
39* MAF_26560356_Chip-Seq_TH1_Human1.77446081
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72706327
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71982147
42VDR_24787735_ChIP-Seq_THP-1_Human1.69274734
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67968215
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67487025
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66481915
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.63933374
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63817888
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62093074
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54255489
50MYB_26560356_Chip-Seq_TH1_Human1.54151165
51* BCL6_27268052_Chip-Seq_Bcells_Human1.51472810
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48540818
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48140833
54MYC_22102868_ChIP-Seq_BL_Human1.43654975
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42996050
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41945465
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41073709
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40018842
59UTX_26944678_Chip-Seq_JUKART_Human1.39382323
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38468775
61TCF7_22412390_ChIP-Seq_EML_Mouse1.37554199
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30979447
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30779602
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30533732
65* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28401482
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25642597
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25437470
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23935425
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21437100
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20803273
71GATA3_27048872_Chip-Seq_THYMUS_Human1.20290394
72BCOR_27268052_Chip-Seq_Bcells_Human1.20129095
73GATA3_26560356_Chip-Seq_TH2_Human1.19651459
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19259600
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18720644
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18558772
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17455861
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16433123
79P68_20966046_ChIP-Seq_HELA_Human1.16134555
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13497264
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13226420
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.11500880
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10758283
84* P300_27268052_Chip-Seq_Bcells_Human1.10634166
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10531872
86FOXP3_21729870_ChIP-Seq_TREG_Human1.09567839
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.09201366
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08823655
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07617106
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.03419075
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03413683
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03093033
93VDR_23849224_ChIP-Seq_CD4+_Human1.02680295
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02665729
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02329999
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02118655
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01947283
98* GATA1_19941827_ChIP-Seq_MEL_Mouse1.01645368
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.01566167
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.00275537
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00032907
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99588617
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99128356
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97600611
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.94794868
106E2F7_22180533_ChIP-Seq_HELA_Human0.91578713
107EGR1_19032775_ChIP-ChIP_M12_Human0.88967955
108GATA2_19941826_ChIP-Seq_K562_Human0.88906388
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88237373
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.85793474
111MAF_26560356_Chip-Seq_TH2_Human0.85392341
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84106175
113* KDM2B_26808549_Chip-Seq_DND41_Human0.84028471
114SPI1_20517297_ChIP-Seq_HL60_Human0.82763591
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82603457
116TFEB_21752829_ChIP-Seq_HELA_Human0.82027411
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79984204
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78926686
119GATA1_19941826_ChIP-Seq_K562_Human0.77333352
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77020488
121SMRT_27268052_Chip-Seq_Bcells_Human0.76470464
122* LXR_22292898_ChIP-Seq_THP-1_Human0.75442287
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70730691
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70338737
125* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68747153
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68528581
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60220847
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59222408
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58399503
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57754145
131* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.57391901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.17998978
2MP0005058_abnormal_lysosome_morphology4.60314346
3MP0006082_CNS_inflammation3.93277980
4MP0003191_abnormal_cellular_cholesterol3.56242154
5MP0003303_peritoneal_inflammation3.43157039
6MP0003436_decreased_susceptibility_to3.35205595
7MP0002148_abnormal_hypersensitivity_rea3.20857723
8MP0002419_abnormal_innate_immunity3.17175782
9MP0005000_abnormal_immune_tolerance3.00092124
10MP0003172_abnormal_lysosome_physiology2.93776154
11MP0005671_abnormal_response_to2.88825648
12MP0002452_abnormal_antigen_presenting2.83245906
13MP0005464_abnormal_platelet_physiology2.83206038
14MP0009785_altered_susceptibility_to2.76150470
15MP0001800_abnormal_humoral_immune2.72213500
16MP0005025_abnormal_response_to2.61293541
17MP0001790_abnormal_immune_system2.60191169
18MP0005387_immune_system_phenotype2.60191169
19MP0002723_abnormal_immune_serum2.50107174
20MP0003690_abnormal_glial_cell2.42890777
21MP0001819_abnormal_immune_cell2.32975969
22MP0002420_abnormal_adaptive_immunity2.31741008
23MP0009840_abnormal_foam_cell2.31704811
24MP0000685_abnormal_immune_system2.26037281
25MP0004510_myositis2.20211302
26MP0008057_abnormal_DNA_replication2.01823725
27MP0002405_respiratory_system_inflammati1.88134570
28MP0001533_abnormal_skeleton_physiology1.84566677
29MP0003724_increased_susceptibility_to1.83940057
30MP0001845_abnormal_inflammatory_respons1.80375317
31MP0003075_altered_response_to1.79876542
32MP0001853_heart_inflammation1.77346509
33MP0000716_abnormal_immune_system1.72970059
34MP0009333_abnormal_splenocyte_physiolog1.70199418
35MP0000343_altered_response_to1.66709595
36MP0000689_abnormal_spleen_morphology1.61821843
37MP0003183_abnormal_peptide_metabolism1.60357412
38MP0002398_abnormal_bone_marrow1.59940556
39MP0008469_abnormal_protein_level1.58327635
40MP0003300_gastrointestinal_ulcer1.54979060
41MP0005310_abnormal_salivary_gland1.54909339
42MP0010094_abnormal_chromosome_stability1.44742773
43MP0010155_abnormal_intestine_physiology1.43664746
44MP0004947_skin_inflammation1.41654304
45MP0002429_abnormal_blood_cell1.40583644
46MP0005166_decreased_susceptibility_to1.39606127
47MP0002722_abnormal_immune_system1.38715581
48MP0005645_abnormal_hypothalamus_physiol1.38231537
49MP0004883_abnormal_blood_vessel1.35178196
50MP0000604_amyloidosis1.32556749
51MP0006036_abnormal_mitochondrial_physio1.32195270
52MP0002019_abnormal_tumor_incidence1.31637619
53MP0001986_abnormal_taste_sensitivity1.29436116
54MP0009764_decreased_sensitivity_to1.28070831
55MP0002998_abnormal_bone_remodeling1.25283536
56MP0002166_altered_tumor_susceptibility1.25142186
57MP0002009_preneoplasia1.19223089
58MP0001851_eye_inflammation1.17942841
59MP0005075_abnormal_melanosome_morpholog1.17672522
60MP0000465_gastrointestinal_hemorrhage1.16905425
61MP0003448_altered_tumor_morphology1.14702293
62MP0002006_tumorigenesis1.12658999
63MP0010307_abnormal_tumor_latency1.12499297
64MP0000569_abnormal_digit_pigmentation1.10185065
65MP0001905_abnormal_dopamine_level1.06195093
66MP0008058_abnormal_DNA_repair1.04994246
67MP0000249_abnormal_blood_vessel1.03940348
68MP0002396_abnormal_hematopoietic_system1.02557697
69MP0005164_abnormal_response_to1.02340874
70MP0002933_joint_inflammation1.01752014
71MP0003656_abnormal_erythrocyte_physiolo0.98893055
72MP0005220_abnormal_exocrine_pancreas0.98742923
73MP0000858_altered_metastatic_potential0.97443777
74MP0003828_pulmonary_edema0.95465127
75MP0001873_stomach_inflammation0.93632857
76MP0005084_abnormal_gallbladder_morpholo0.93327778
77MP0009697_abnormal_copulation0.93057988
78MP0009278_abnormal_bone_marrow0.88812178
79MP0005174_abnormal_tail_pigmentation0.87484576
80MP0004782_abnormal_surfactant_physiolog0.86503751
81MP0003763_abnormal_thymus_physiology0.84176268
82MP0009763_increased_sensitivity_to0.83636315
83MP0003111_abnormal_nucleus_morphology0.83269464
84MP0005390_skeleton_phenotype0.83120570
85MP0005167_abnormal_blood-brain_barrier0.82509167
86MP0006035_abnormal_mitochondrial_morpho0.82343255
87MP0003566_abnormal_cell_adhesion0.80715257
88MP0001545_abnormal_hematopoietic_system0.79661283
89MP0005397_hematopoietic_system_phenotyp0.79661283
90MP0008260_abnormal_autophagy0.79526626
91MP0008004_abnormal_stomach_pH0.79276449
92MP0004808_abnormal_hematopoietic_stem0.78705217
93MP0002653_abnormal_ependyma_morphology0.78564366
94MP0003806_abnormal_nucleotide_metabolis0.77196317
95MP0000015_abnormal_ear_pigmentation0.77090977
96MP0003252_abnormal_bile_duct0.73801099
97MP0002090_abnormal_vision0.73792988
98MP0002136_abnormal_kidney_physiology0.72401729
99MP0001915_intracranial_hemorrhage0.72171762
100MP0001663_abnormal_digestive_system0.71976987
101MP0003786_premature_aging0.71881856
102MP0005451_abnormal_body_composition0.71797192
103MP0003795_abnormal_bone_structure0.71754596
104MP0003045_fibrosis0.70794752
105MP0001881_abnormal_mammary_gland0.70776165
106MP0000681_abnormal_thyroid_gland0.70627911
107MP0000920_abnormal_myelination0.69013905
108MP0000313_abnormal_cell_death0.68418888
109MP0000767_abnormal_smooth_muscle0.68341161
110MP0008873_increased_physiological_sensi0.67699340
111MP0003787_abnormal_imprinting0.67689480
112MP0002132_abnormal_respiratory_system0.65944011
113MP0000703_abnormal_thymus_morphology0.65713238
114MP0001764_abnormal_homeostasis0.65257104
115MP0000609_abnormal_liver_physiology0.65150157
116MP0002970_abnormal_white_adipose0.63941657
117MP0005319_abnormal_enzyme/_coenzyme0.63699445
118MP0005535_abnormal_body_temperature0.62727397
119MP0000371_diluted_coat_color0.61588302
120MP0005165_increased_susceptibility_to0.61466697
121MP0002083_premature_death0.60893230
122MP0003866_abnormal_defecation0.59541402
123MP0005584_abnormal_enzyme/coenzyme_acti0.59446285
124MP0003279_aneurysm0.59097402
125MP0005266_abnormal_metabolism0.58772984
126MP0008007_abnormal_cellular_replicative0.58754840
127MP0005023_abnormal_wound_healing0.58517788
128MP0005376_homeostasis/metabolism_phenot0.58272006
129MP0000490_abnormal_crypts_of0.54543230
130MP0002135_abnormal_kidney_morphology0.53197542
131MP0002277_abnormal_respiratory_mucosa0.52579795
132MP0002254_reproductive_system_inflammat0.52479229
133MP0008438_abnormal_cutaneous_collagen0.51952050
134MP0000598_abnormal_liver_morphology0.51609066

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.97797881
2Recurrent bacterial skin infections (HP:0005406)6.64952101
3Systemic lupus erythematosus (HP:0002725)6.40316952
4Abnormality of glycolipid metabolism (HP:0010969)5.51409294
5Abnormality of liposaccharide metabolism (HP:0010968)5.51409294
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.51409294
7Eczematoid dermatitis (HP:0000976)5.46763546
8Glomerulonephritis (HP:0000099)5.10055860
9Vacuolated lymphocytes (HP:0001922)5.03608994
10Increased cerebral lipofuscin (HP:0011813)4.97299267
11Recurrent gram-negative bacterial infections (HP:0005420)4.76740129
12Dysostosis multiplex (HP:0000943)4.65188072
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.59219030
14Increased IgE level (HP:0003212)4.08040983
15Recurrent skin infections (HP:0001581)3.97392237
16Abnormality of macrophages (HP:0004311)3.95023365
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.86609122
18Complement deficiency (HP:0004431)3.72833271
19B lymphocytopenia (HP:0010976)3.72071696
20Abnormality of complement system (HP:0005339)3.62995668
21Disinhibition (HP:0000734)3.60720854
22Abnormality of B cell number (HP:0010975)3.59387967
23Elevated erythrocyte sedimentation rate (HP:0003565)3.59184764
24Verrucae (HP:0200043)3.56084730
25Papilloma (HP:0012740)3.56084730
26Cellulitis (HP:0100658)3.48012724
27Mediastinal lymphadenopathy (HP:0100721)3.45846810
28Axonal loss (HP:0003447)3.45040127
29Urinary glycosaminoglycan excretion (HP:0003541)3.43298455
30Mucopolysacchariduria (HP:0008155)3.43298455
31Myositis (HP:0100614)3.41321189
32Recurrent viral infections (HP:0004429)3.36274872
33Colitis (HP:0002583)3.28279439
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24455916
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24455916
36Abnormality of polysaccharide metabolism (HP:0011012)3.24455916
37Gingivitis (HP:0000230)3.21571089
38Chronic obstructive pulmonary disease (HP:0006510)3.19727559
39Obstructive lung disease (HP:0006536)3.19727559
40Recurrent fungal infections (HP:0002841)3.18289906
41Thrombocytosis (HP:0001894)3.12474716
42Nephritis (HP:0000123)3.05588884
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.05495771
44Granulocytopenia (HP:0001913)2.99031747
45Hepatosplenomegaly (HP:0001433)2.98779032
46Chronic otitis media (HP:0000389)2.98309478
47Agnosia (HP:0010524)2.96788051
48Skin rash (HP:0000988)2.96138848
49Amyloidosis (HP:0011034)2.95372886
50Orchitis (HP:0100796)2.89486796
51Upper motor neuron abnormality (HP:0002127)2.87366888
52Agammaglobulinemia (HP:0004432)2.87094449
53Hematochezia (HP:0002573)2.86537789
54Meningitis (HP:0001287)2.83884199
55Pustule (HP:0200039)2.82192581
56Encephalitis (HP:0002383)2.81152644
57Severe combined immunodeficiency (HP:0004430)2.79057744
58J-shaped sella turcica (HP:0002680)2.78550282
59Chronic sinusitis (HP:0011109)2.78063605
60Autoimmune hemolytic anemia (HP:0001890)2.77777527
61Inflammation of the large intestine (HP:0002037)2.74169785
62Autoimmune thrombocytopenia (HP:0001973)2.73604169
63Osteomyelitis (HP:0002754)2.73169279
64Vasculitis (HP:0002633)2.68420626
65IgM deficiency (HP:0002850)2.63830200
66Recurrent pneumonia (HP:0006532)2.63795817
67Loss of speech (HP:0002371)2.59639937
68Abnormal platelet function (HP:0011869)2.58881855
69Impaired platelet aggregation (HP:0003540)2.58881855
70Microvesicular hepatic steatosis (HP:0001414)2.57859618
71Gastrointestinal inflammation (HP:0004386)2.54887802
72Hypergammaglobulinemia (HP:0010702)2.54119842
73Basal ganglia calcification (HP:0002135)2.53255559
74Spondylolisthesis (HP:0003302)2.52961141
75Stomatitis (HP:0010280)2.51687760
76Cerebral palsy (HP:0100021)2.50778200
77Interstitial pulmonary disease (HP:0006530)2.48913986
78Panhypogammaglobulinemia (HP:0003139)2.48159393
79Chronic mucocutaneous candidiasis (HP:0002728)2.47199022
80Recurrent cutaneous fungal infections (HP:0011370)2.47199022
81Dicarboxylic aciduria (HP:0003215)2.47117927
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47117927
83Thick nail (HP:0001805)2.44704024
84Periodontitis (HP:0000704)2.44569424
85Skin ulcer (HP:0200042)2.44011436
86Abnormality of T cell physiology (HP:0011840)2.42359853
87Spontaneous hematomas (HP:0007420)2.40843451
88Petechiae (HP:0000967)2.39964076
89Chest pain (HP:0100749)2.39575018
90Hypertensive crisis (HP:0100735)2.36926938
91Pulmonary infiltrates (HP:0002113)2.36253414
92Eosinophilia (HP:0001880)2.35674095
933-Methylglutaconic aciduria (HP:0003535)2.35360458
94Retrobulbar optic neuritis (HP:0100654)2.34432682
95Optic neuritis (HP:0100653)2.34432682
96Pathologic fracture (HP:0002756)2.33865858
97Chronic diarrhea (HP:0002028)2.33494172
98Ragged-red muscle fibers (HP:0003200)2.31809680
99Progressive neurologic deterioration (HP:0002344)2.31561549
100Thoracic kyphosis (HP:0002942)2.29857265
101Prostate neoplasm (HP:0100787)2.29011477
102Recurrent lower respiratory tract infections (HP:0002783)2.28118663
103Abnormality of the prostate (HP:0008775)2.25596612
104Combined immunodeficiency (HP:0005387)2.25573453
105Joint hemorrhage (HP:0005261)2.25226306
106Epistaxis (HP:0000421)2.24632262
107Urethral obstruction (HP:0000796)2.21691240
108Mutism (HP:0002300)2.20188718
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19738704
110Viral hepatitis (HP:0006562)2.15638873
111Acute lymphatic leukemia (HP:0006721)2.13794528
112Leukocytosis (HP:0001974)2.09817659
113Gastrointestinal stroma tumor (HP:0100723)2.09313634
114Multiple enchondromatosis (HP:0005701)2.09139743
115Aplasia/Hypoplasia of the thymus (HP:0010515)2.07079181
116Abnormality of the lumbar spine (HP:0100712)2.06995902
117Progressive microcephaly (HP:0000253)2.05117712
118Xerostomia (HP:0000217)2.04929172
119Prolonged bleeding time (HP:0003010)2.04859025
120Pulmonary fibrosis (HP:0002206)2.04750542
121Urticaria (HP:0001025)2.04452468
122Abnormality of male internal genitalia (HP:0000022)2.03841069
123Myocardial infarction (HP:0001658)2.03419897
124Deformed sella turcica (HP:0002681)2.02669073
125Reduced antithrombin III activity (HP:0001976)2.01944935
126Abnormality of the pleura (HP:0002103)2.01039129
127Retinal atrophy (HP:0001105)1.97473317
128Neutropenia (HP:0001875)1.96938270
129Arterial tortuosity (HP:0005116)1.96654952
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.95896787
131Osteolytic defects of the hand bones (HP:0009699)1.95896787
132Purpura (HP:0000979)1.94554063
133Apathy (HP:0000741)1.93395732
134Type I transferrin isoform profile (HP:0003642)1.93316912
135Mucosal telangiectasiae (HP:0100579)1.90704248
136Diminished motivation (HP:0000745)1.89582022
137Sepsis (HP:0100806)1.89286574
138Abnormality of T cells (HP:0002843)1.88025511
139Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85249560
140Emphysema (HP:0002097)1.85123678
141Increased IgM level (HP:0003496)1.85122779
142Hypoplasia of the thymus (HP:0000778)1.83152955
143Recurrent bronchitis (HP:0002837)1.82569776
144Progressive visual loss (HP:0000529)1.81768091
145Lymphopenia (HP:0001888)1.81699592
146Abnormality of small intestinal villus morphology (HP:0011472)1.77929349
147Villous atrophy (HP:0011473)1.77929349
148Gingival bleeding (HP:0000225)1.76689595
149Fatigue (HP:0012378)1.74577700
150Hepatocellular necrosis (HP:0001404)1.74357218
151Hemoptysis (HP:0002105)1.73885480
152Mesangial abnormality (HP:0001966)1.73118362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.28846340
2TGFBR24.24938860
3MAP4K13.95255411
4TESK23.63858578
5TYK23.45736816
6RIPK43.26483833
7MAP3K142.98947057
8ERN12.98776092
9IRAK42.91064918
10CSF1R2.86521829
11VRK22.76677208
12KIT2.74476695
13TBK12.70687187
14KDR2.65068447
15NEK92.61960095
16GRK72.38640408
17TNK22.18308542
18STK102.02925120
19BCKDK2.01530820
20MAP3K111.99277448
21JAK11.98091976
22IKBKB1.93424931
23IRAK31.87158775
24SYK1.80745592
25PDK21.77931954
26ZAP701.77628790
27TXK1.77396095
28CLK11.70214563
29IKBKE1.60824778
30BTK1.56522841
31CSK1.55871193
32TEC1.53008564
33LYN1.51014436
34CDK191.50453843
35MATK1.46287261
36MAP2K31.42948634
37CDC71.42448007
38FES1.38524953
39HCK1.37962244
40TAOK31.32720412
41ITK1.29824440
42PIM21.27255889
43TESK11.23184980
44JAK31.21259392
45JAK21.17370105
46RPS6KA41.12375990
47LCK1.10121621
48MOS1.06320373
49MAPK71.01911971
50FGR1.01377236
51CDK40.97786094
52VRK10.93262510
53BMPR20.91563173
54CHUK0.86377996
55ARAF0.84098701
56MAPK120.82983041
57TRIB30.80498634
58PIM10.80100540
59CAMK1D0.79986611
60PKN20.79612161
61MAPK110.78714274
62EPHB10.77849860
63GRK60.76988013
64MAP3K130.76103030
65STK160.75566785
66PDK10.73409881
67DAPK10.69753044
68ZAK0.68473964
69ATR0.68440176
70PAK40.65366468
71CAMKK10.62983636
72RPS6KA60.61021049
73EGFR0.60828917
74CDK60.60414369
75PRKCD0.56137738
76TAOK10.54726380
77EIF2AK20.54292618
78RPS6KC10.53395648
79RPS6KL10.53395648
80FGFR40.53089395
81TRPM70.52570223
82MAPKAPK20.52303348
83BMX0.52119148
84MAPKAPK30.51998416
85FGFR30.51626286
86LIMK10.51118096
87MARK30.51063910
88RPS6KA50.49977357
89MAP3K10.49486930
90NME20.48778197
91CHEK20.48382519
92ABL10.46644367
93PRKCQ0.45922824
94RPS6KA20.45250583
95HIPK20.44972948
96PLK40.44636871
97LRRK20.44043626
98STK40.42462140
99CSNK1G30.41986347
100IGF1R0.41868649
101PRKD10.41822584
102PDPK10.41808367
103PTK60.40665743
104EEF2K0.40522640
105CDK70.39262581
106CCNB10.39154299
107TAOK20.39145670
108SCYL20.38863847
109MAPK150.38760427
110SIK20.38554258
111MAP3K100.38304477
112CAMK1G0.37936943
113PIK3CG0.37906611
114MAPK130.37267452
115GRK50.36790725
116TLK10.36542370
117MAPK30.33672884
118CAMKK20.33023095
119PRKD20.32910498
120ABL20.32845489
121MAP3K60.32708868
122FYN0.32489236
123ADRBK20.31742296
124FLT30.31339952
125AURKA0.31007947
126RPS6KB20.30344140
127YES10.28708998
128MAPK40.28532576
129MAP4K20.27882602
130CDK80.25002095
131MAP3K30.24539116
132TTN0.24524157
133SGK30.23716125
134MAP3K80.23121784
135NEK60.21367934
136CDK90.21170327

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.26551539
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.97786260
3Other glycan degradation_Homo sapiens_hsa005113.74267034
4DNA replication_Homo sapiens_hsa030303.39185516
5Lysosome_Homo sapiens_hsa041423.28110968
6Leishmaniasis_Homo sapiens_hsa051403.08450300
7Osteoclast differentiation_Homo sapiens_hsa043802.75109944
8B cell receptor signaling pathway_Homo sapiens_hsa046622.70632120
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37437339
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35044071
11Pertussis_Homo sapiens_hsa051332.24403503
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.18936842
13Tuberculosis_Homo sapiens_hsa051522.18889245
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.14265260
15Antigen processing and presentation_Homo sapiens_hsa046122.03946974
16Legionellosis_Homo sapiens_hsa051341.86710991
17Primary immunodeficiency_Homo sapiens_hsa053401.83455237
18Mismatch repair_Homo sapiens_hsa034301.80489448
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77512724
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66589366
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65095776
22Malaria_Homo sapiens_hsa051441.62278043
23Measles_Homo sapiens_hsa051621.61376904
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59606037
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.59129818
26Homologous recombination_Homo sapiens_hsa034401.55936949
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55023874
28Phagosome_Homo sapiens_hsa041451.54275483
29Toxoplasmosis_Homo sapiens_hsa051451.51832714
30Salmonella infection_Homo sapiens_hsa051321.43216308
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41523473
32Influenza A_Homo sapiens_hsa051641.40835798
33Hematopoietic cell lineage_Homo sapiens_hsa046401.40750215
34Chemokine signaling pathway_Homo sapiens_hsa040621.40427640
35Rheumatoid arthritis_Homo sapiens_hsa053231.34824054
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34634967
37Apoptosis_Homo sapiens_hsa042101.33262153
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31581203
39Complement and coagulation cascades_Homo sapiens_hsa046101.30923694
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30810271
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27557813
42Graft-versus-host disease_Homo sapiens_hsa053321.27244157
43Fanconi anemia pathway_Homo sapiens_hsa034601.21358943
44Pyrimidine metabolism_Homo sapiens_hsa002401.21262546
45Shigellosis_Homo sapiens_hsa051311.18323011
46Platelet activation_Homo sapiens_hsa046111.17017083
47TNF signaling pathway_Homo sapiens_hsa046681.14278919
48Herpes simplex infection_Homo sapiens_hsa051681.10407439
49Asthma_Homo sapiens_hsa053101.08147530
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.06351116
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03863563
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.02880924
53Pancreatic cancer_Homo sapiens_hsa052120.98127932
54Allograft rejection_Homo sapiens_hsa053300.98025369
55Ribosome_Homo sapiens_hsa030100.97740182
56Nucleotide excision repair_Homo sapiens_hsa034200.97403345
57Hepatitis B_Homo sapiens_hsa051610.95558219
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92188150
59Prion diseases_Homo sapiens_hsa050200.91304179
60African trypanosomiasis_Homo sapiens_hsa051430.89965639
61Chronic myeloid leukemia_Homo sapiens_hsa052200.87853489
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85752891
63T cell receptor signaling pathway_Homo sapiens_hsa046600.84278031
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81249120
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77192218
66Acute myeloid leukemia_Homo sapiens_hsa052210.76387158
67Viral myocarditis_Homo sapiens_hsa054160.76182309
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74697268
69Hepatitis C_Homo sapiens_hsa051600.74054331
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72670034
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64031040
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62979647
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.61892200
74Non-homologous end-joining_Homo sapiens_hsa034500.60522654
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.59419550
76RNA polymerase_Homo sapiens_hsa030200.57683316
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53303240
78Amoebiasis_Homo sapiens_hsa051460.53209788
79Endocytosis_Homo sapiens_hsa041440.51629535
80Proteasome_Homo sapiens_hsa030500.50963300
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50778570
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.50015166
83Sulfur relay system_Homo sapiens_hsa041220.48321996
84Caffeine metabolism_Homo sapiens_hsa002320.48281130
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48159309
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47562918
87Epstein-Barr virus infection_Homo sapiens_hsa051690.46546377
88Parkinsons disease_Homo sapiens_hsa050120.46112671
89Purine metabolism_Homo sapiens_hsa002300.44118849
90Arachidonic acid metabolism_Homo sapiens_hsa005900.41768317
91Oxidative phosphorylation_Homo sapiens_hsa001900.40885422
92Spliceosome_Homo sapiens_hsa030400.40552537
93Renin-angiotensin system_Homo sapiens_hsa046140.40406013
94Regulation of autophagy_Homo sapiens_hsa041400.39888968
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37566606
96Viral carcinogenesis_Homo sapiens_hsa052030.37467729
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37188637
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36569808
99ABC transporters_Homo sapiens_hsa020100.35801955
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35692246
101Pentose phosphate pathway_Homo sapiens_hsa000300.34627509
102Glutathione metabolism_Homo sapiens_hsa004800.33967775
103Base excision repair_Homo sapiens_hsa034100.32408373
104Type I diabetes mellitus_Homo sapiens_hsa049400.31752975
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30625397
106Sphingolipid metabolism_Homo sapiens_hsa006000.30350554
107Non-small cell lung cancer_Homo sapiens_hsa052230.30071658
108VEGF signaling pathway_Homo sapiens_hsa043700.29614988
109Notch signaling pathway_Homo sapiens_hsa043300.28755777
110Prolactin signaling pathway_Homo sapiens_hsa049170.28722666
111HIF-1 signaling pathway_Homo sapiens_hsa040660.28636930
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24062276
113Autoimmune thyroid disease_Homo sapiens_hsa053200.23200073
114Colorectal cancer_Homo sapiens_hsa052100.22730297
115Collecting duct acid secretion_Homo sapiens_hsa049660.21628349
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21325877
117HTLV-I infection_Homo sapiens_hsa051660.20758608
118Peroxisome_Homo sapiens_hsa041460.20337407
119MAPK signaling pathway_Homo sapiens_hsa040100.19851658
120N-Glycan biosynthesis_Homo sapiens_hsa005100.19382323
121Alcoholism_Homo sapiens_hsa050340.18462519
122Small cell lung cancer_Homo sapiens_hsa052220.18141633
123Starch and sucrose metabolism_Homo sapiens_hsa005000.17194268
124Huntingtons disease_Homo sapiens_hsa050160.16154040
125FoxO signaling pathway_Homo sapiens_hsa040680.15697110
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.15366439
127Alzheimers disease_Homo sapiens_hsa050100.14924548
128Systemic lupus erythematosus_Homo sapiens_hsa053220.14387309
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.13398248
130Fructose and mannose metabolism_Homo sapiens_hsa000510.12398846
131Proteoglycans in cancer_Homo sapiens_hsa052050.11615476
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11506820
133Fatty acid elongation_Homo sapiens_hsa000620.08691663
134Cell cycle_Homo sapiens_hsa041100.06606819

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