PLD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* piRNA metabolic process (GO:0034587)8.53792319
2cilium or flagellum-dependent cell motility (GO:0001539)7.91863730
3fusion of sperm to egg plasma membrane (GO:0007342)7.62837239
4axonemal dynein complex assembly (GO:0070286)7.10018228
5sperm-egg recognition (GO:0035036)6.93384349
6sperm motility (GO:0030317)6.64345760
7male meiosis (GO:0007140)6.64196298
8cell wall macromolecule catabolic process (GO:0016998)6.57317869
9cell wall macromolecule metabolic process (GO:0044036)6.57317869
10binding of sperm to zona pellucida (GO:0007339)6.52504659
11motile cilium assembly (GO:0044458)6.42608747
12synaptonemal complex organization (GO:0070193)6.41224914
13multicellular organism reproduction (GO:0032504)6.26154893
14acrosome assembly (GO:0001675)6.25769199
15synaptonemal complex assembly (GO:0007130)6.23806032
16cell-cell recognition (GO:0009988)6.12354337
17* spermatid development (GO:0007286)5.85752345
18* DNA methylation involved in gamete generation (GO:0043046)5.83706128
19epithelial cilium movement (GO:0003351)5.63983799
20acrosome reaction (GO:0007340)5.63489559
21plasma membrane fusion (GO:0045026)5.55284812
22male meiosis I (GO:0007141)5.17298864
23microtubule depolymerization (GO:0007019)5.07860741
24regulation of cilium movement (GO:0003352)4.93378284
25chromosome organization involved in meiosis (GO:0070192)4.92730886
26* meiotic nuclear division (GO:0007126)4.87465040
27reproduction (GO:0000003)4.85552549
28cilium movement (GO:0003341)4.69066724
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55391170
30regulation of meiosis I (GO:0060631)4.37513783
31meiosis I (GO:0007127)4.34721930
32DNA deamination (GO:0045006)4.31708431
33single fertilization (GO:0007338)4.21114432
34meiotic cell cycle (GO:0051321)4.17682323
35spermatogenesis (GO:0007283)3.98671002
36male gamete generation (GO:0048232)3.98275844
37pseudouridine synthesis (GO:0001522)3.93437884
38fertilization (GO:0009566)3.90461748
39DNA replication initiation (GO:0006270)3.85788102
40protein K6-linked ubiquitination (GO:0085020)3.82263412
41maturation of 5.8S rRNA (GO:0000460)3.74217759
42meiotic cell cycle process (GO:1903046)3.73786113
43gamete generation (GO:0007276)3.68741858
44* germ cell development (GO:0007281)3.64843342
45regulation of mitochondrial translation (GO:0070129)3.64593714
46mitochondrial RNA metabolic process (GO:0000959)3.63439287
47histone exchange (GO:0043486)3.61569756
48meiotic chromosome segregation (GO:0045132)3.59438560
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.55061705
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.55061705
51nuclear pore complex assembly (GO:0051292)3.51274568
52gene silencing by RNA (GO:0031047)3.45255988
53rRNA catabolic process (GO:0016075)3.45012993
54sperm capacitation (GO:0048240)3.44039373
55regulation of spindle checkpoint (GO:0090231)3.42327362
56* cellular process involved in reproduction in multicellular organism (GO:0022412)3.40638946
57DNA strand elongation involved in DNA replication (GO:0006271)3.38769332
58DNA replication-dependent nucleosome organization (GO:0034723)3.36591553
59DNA replication-dependent nucleosome assembly (GO:0006335)3.36591553
60respiratory chain complex IV assembly (GO:0008535)3.34972159
61telomere maintenance via semi-conservative replication (GO:0032201)3.30836649
62spermatid nucleus differentiation (GO:0007289)3.29480226
63nuclear pore organization (GO:0006999)3.29368950
64centriole assembly (GO:0098534)3.28916455
65DNA strand elongation (GO:0022616)3.25727144
66positive regulation of protein homooligomerization (GO:0032464)3.21640804
67tRNA modification (GO:0006400)3.21451657
68DNA packaging (GO:0006323)3.20888738
69sister chromatid cohesion (GO:0007062)3.20649193
70tRNA processing (GO:0008033)3.18886585
71ventricular system development (GO:0021591)3.18015165
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18009806
73chromatin remodeling at centromere (GO:0031055)3.16316914
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.16229487
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.15011179
76chromosome condensation (GO:0030261)3.14535664
77synapsis (GO:0007129)3.14483872
78centriole replication (GO:0007099)3.13989176
79rRNA processing (GO:0006364)3.12584569
80protein polyglutamylation (GO:0018095)3.11250565
81rRNA metabolic process (GO:0016072)3.09967552
82cytochrome complex assembly (GO:0017004)3.09112623
83regulation of centriole replication (GO:0046599)3.09023722
84metallo-sulfur cluster assembly (GO:0031163)3.08934119
85iron-sulfur cluster assembly (GO:0016226)3.08934119
86mitochondrial respiratory chain complex assembly (GO:0033108)3.08809858
87seminiferous tubule development (GO:0072520)3.07970578
88DNA replication checkpoint (GO:0000076)3.07184342
89replication fork processing (GO:0031297)3.06039579
90kinetochore organization (GO:0051383)3.05392997
91transcription from mitochondrial promoter (GO:0006390)3.03935656
92regulation of histone H3-K9 methylation (GO:0051570)3.00444006
93negative regulation of inclusion body assembly (GO:0090084)2.99797345
94single strand break repair (GO:0000012)2.97372052
95protein complex biogenesis (GO:0070271)2.96943578
96reciprocal DNA recombination (GO:0035825)2.95935596
97reciprocal meiotic recombination (GO:0007131)2.95935596
98behavioral response to nicotine (GO:0035095)2.95555007
99telomere maintenance via recombination (GO:0000722)2.95413481
100microtubule severing (GO:0051013)2.94567831
101CENP-A containing nucleosome assembly (GO:0034080)2.90759630
102monoubiquitinated protein deubiquitination (GO:0035520)2.89705826
103translesion synthesis (GO:0019985)2.88269179
104ncRNA processing (GO:0034470)2.87662213
105protein localization to chromosome, centromeric region (GO:0071459)2.86585357
106kinetochore assembly (GO:0051382)2.86160634
107rRNA modification (GO:0000154)2.85759999
108mitotic sister chromatid segregation (GO:0000070)2.85172192
109tRNA metabolic process (GO:0006399)2.84660403
110rRNA transcription (GO:0009303)2.82840435
111* DNA alkylation (GO:0006305)2.82707558
112* DNA methylation (GO:0006306)2.82707558
113microtubule polymerization or depolymerization (GO:0031109)2.82486293
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82392961
115mitochondrial respiratory chain complex I assembly (GO:0032981)2.82392961
116NADH dehydrogenase complex assembly (GO:0010257)2.82392961
117ribosome biogenesis (GO:0042254)2.82052617
118multicellular organismal reproductive process (GO:0048609)2.81886033
119protein K11-linked deubiquitination (GO:0035871)2.80167227
120CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79870553
121protoporphyrinogen IX metabolic process (GO:0046501)2.79432380
122chromosome organization (GO:0051276)2.79385609
123organic cation transport (GO:0015695)2.77994980
124folic acid-containing compound biosynthetic process (GO:0009396)2.77411554
125nucleus organization (GO:0006997)2.75381248
126regulation of microtubule-based movement (GO:0060632)2.75205548
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.74915957
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74915957
129protein localization to cilium (GO:0061512)2.74232372
130histone H2A acetylation (GO:0043968)2.73745141
131intraciliary transport (GO:0042073)2.72858473
132ribonucleoprotein complex biogenesis (GO:0022613)2.71150016
133pore complex assembly (GO:0046931)2.70631885
134intra-S DNA damage checkpoint (GO:0031573)2.70406544
135mitotic recombination (GO:0006312)2.70037030
136ubiquinone biosynthetic process (GO:0006744)2.68848769
137cellular component biogenesis (GO:0044085)2.68812246
138RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.68178591
139* ncRNA metabolic process (GO:0034660)2.67447384
140RNA modification (GO:0009451)2.66322857
141preassembly of GPI anchor in ER membrane (GO:0016254)2.65951927
142protoporphyrinogen IX biosynthetic process (GO:0006782)2.65821525
143mannosylation (GO:0097502)2.65748651
144methionine biosynthetic process (GO:0009086)2.64024326
145maturation of SSU-rRNA (GO:0030490)2.63681246
146heme biosynthetic process (GO:0006783)2.57752042
147rRNA methylation (GO:0031167)2.56999182
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56444273
149peptidyl-histidine modification (GO:0018202)2.56382487
150L-fucose catabolic process (GO:0042355)2.54586766
151fucose catabolic process (GO:0019317)2.54586766
152L-fucose metabolic process (GO:0042354)2.54586766
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.54415021
154termination of RNA polymerase III transcription (GO:0006386)2.54415021
155negative regulation of telomere maintenance (GO:0032205)2.51601881
156pteridine-containing compound biosynthetic process (GO:0042559)2.51442556
157L-methionine salvage (GO:0071267)2.51082796
158L-methionine biosynthetic process (GO:0071265)2.51082796
159amino acid salvage (GO:0043102)2.51082796
160protein-cofactor linkage (GO:0018065)2.50339918
161tRNA methylation (GO:0030488)2.49214018
162pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47514224
163exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45646079
164folic acid metabolic process (GO:0046655)2.43808624
165ribosome assembly (GO:0042255)2.42723474
166recombinational repair (GO:0000725)2.42517785
167nucleobase biosynthetic process (GO:0046112)2.42449332
168RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41934034
169double-strand break repair via homologous recombination (GO:0000724)2.40597386
170protein targeting to mitochondrion (GO:0006626)2.39847635
171establishment of protein localization to mitochondrion (GO:0072655)2.38795951
172viral mRNA export from host cell nucleus (GO:0046784)2.37132373
173somatic diversification of immunoglobulins (GO:0016445)2.34862556
174nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33084914
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.32698963
176pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.30347328
177tetrapyrrole biosynthetic process (GO:0033014)2.30191531
178ubiquinone metabolic process (GO:0006743)2.29416111
179RNA phosphodiester bond hydrolysis (GO:0090501)2.29227153
180negative regulation of B cell apoptotic process (GO:0002903)2.27484337
181T cell lineage commitment (GO:0002360)2.26804660
182nucleotide-excision repair, DNA gap filling (GO:0006297)2.26754507
183positive regulation of megakaryocyte differentiation (GO:0045654)2.26582225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.21433761
2E2F7_22180533_ChIP-Seq_HELA_Human6.63392926
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.93189136
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87090560
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73681051
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.63814988
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57307235
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48787095
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45176586
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39433565
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.30053917
12CIITA_25753668_ChIP-Seq_RAJI_Human2.28252868
13ZNF274_21170338_ChIP-Seq_K562_Hela2.20944102
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18774063
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13081331
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07584228
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97596151
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.97587237
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93870207
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93341053
21MYC_22102868_ChIP-Seq_BL_Human1.84555573
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80988901
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80779600
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80511365
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.80273111
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.80175411
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79582688
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77102795
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76945879
30MYC_18940864_ChIP-ChIP_HL60_Human1.75709246
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75207748
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.73969847
33VDR_23849224_ChIP-Seq_CD4+_Human1.70440379
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.69181121
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62670857
36IRF1_19129219_ChIP-ChIP_H3396_Human1.62059246
37FOXP3_21729870_ChIP-Seq_TREG_Human1.61585851
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59059199
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53836887
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.53376378
41XRN2_22483619_ChIP-Seq_HELA_Human1.52779997
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52594216
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52391480
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48713888
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41780439
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41739997
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38720905
48GABP_19822575_ChIP-Seq_HepG2_Human1.36772349
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36662845
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36395346
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.36157489
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36068793
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34648597
54DCP1A_22483619_ChIP-Seq_HELA_Human1.34203411
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34145139
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31734722
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28836452
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28358271
59AR_21909140_ChIP-Seq_LNCAP_Human1.25784540
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22926286
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22841454
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22615743
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22557761
64* TP53_22573176_ChIP-Seq_HFKS_Human1.21570140
65* TTF2_22483619_ChIP-Seq_HELA_Human1.20421365
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18826270
67ELK1_19687146_ChIP-ChIP_HELA_Human1.18462084
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18192168
69TFEB_21752829_ChIP-Seq_HELA_Human1.18026480
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17058656
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.15362909
72VDR_21846776_ChIP-Seq_THP-1_Human1.15300827
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13143914
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.12421763
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12155138
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11920563
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.10596967
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08735387
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07926256
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07706100
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06716777
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06646130
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.06529909
84* MAF_26560356_Chip-Seq_TH2_Human1.06492609
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05772689
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04922451
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02971706
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.01629017
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00299210
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97592436
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97219375
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97127270
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.96063569
94GATA3_21867929_ChIP-Seq_CD8_Mouse0.94789006
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94670104
96BCL6_27268052_Chip-Seq_Bcells_Human0.94405815
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94260598
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94104279
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94095370
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93971077
101VDR_22108803_ChIP-Seq_LS180_Human0.93472916
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92124359
103PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91066575
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91044355
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90913163
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90679010
107P68_20966046_ChIP-Seq_HELA_Human0.90581739
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.90292839
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89531914
110LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89050664
111RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87825844
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87788698
113SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87097372
114E2F1_20622854_ChIP-Seq_HELA_Human0.86363029
115ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85467144
116* ERA_21632823_ChIP-Seq_H3396_Human0.85263645
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.85252530
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84882273
119BCOR_27268052_Chip-Seq_Bcells_Human0.84643493
120MYB_26560356_Chip-Seq_TH2_Human0.84590104
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84582588
122KDM5A_27292631_Chip-Seq_BREAST_Human0.84431700
123FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83927531
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83284908
125PHF8_20622854_ChIP-Seq_HELA_Human0.82500265
126STAT1_17558387_ChIP-Seq_HELA_Human0.82058600
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.81742210
128* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78846634
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78519899
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78076013
131FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77972617
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77935110
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77455080
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76830805
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76781022
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76734881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.17398928
2MP0008877_abnormal_DNA_methylation5.42202686
3MP0008057_abnormal_DNA_replication5.06220157
4MP0001929_abnormal_gametogenesis4.23583232
5MP0010094_abnormal_chromosome_stability4.12554384
6MP0003698_abnormal_male_reproductive4.00063867
7MP0002210_abnormal_sex_determination3.51501966
8MP0008058_abnormal_DNA_repair3.44669432
9MP0003693_abnormal_embryo_hatching3.37685966
10MP0003111_abnormal_nucleus_morphology3.01254699
11MP0001145_abnormal_male_reproductive2.95105708
12MP0008007_abnormal_cellular_replicative2.86867609
13MP0003077_abnormal_cell_cycle2.71167539
14MP0000653_abnormal_sex_gland2.61566232
15MP0006292_abnormal_olfactory_placode2.54549012
16MP0003786_premature_aging2.51612102
17MP0004147_increased_porphyrin_level2.41423253
18MP0004957_abnormal_blastocyst_morpholog2.40028702
19MP0002653_abnormal_ependyma_morphology2.39146901
20MP0002161_abnormal_fertility/fecundity2.31564269
21MP0003656_abnormal_erythrocyte_physiolo2.30669974
22MP0002163_abnormal_gland_morphology2.29655259
23MP0005645_abnormal_hypothalamus_physiol2.11495464
24MP0008995_early_reproductive_senescence2.00352843
25MP0002160_abnormal_reproductive_system1.99749098
26MP0009046_muscle_twitch1.86588298
27MP0008932_abnormal_embryonic_tissue1.66350825
28MP0001873_stomach_inflammation1.58464930
29MP0008872_abnormal_physiological_respon1.56880848
30MP0005671_abnormal_response_to1.54617951
31MP0001968_abnormal_touch/_nociception1.46644840
32MP0000372_irregular_coat_pigmentation1.43920230
33MP0002166_altered_tumor_susceptibility1.41079308
34MP0009333_abnormal_splenocyte_physiolog1.40996499
35MP0001730_embryonic_growth_arrest1.39103974
36MP0003718_maternal_effect1.38041218
37MP0005310_abnormal_salivary_gland1.37233614
38MP0008875_abnormal_xenobiotic_pharmacok1.35091586
39MP0005379_endocrine/exocrine_gland_phen1.34769887
40MP0002006_tumorigenesis1.29544567
41MP0008961_abnormal_basal_metabolism1.25754701
42MP0003646_muscle_fatigue1.22651019
43MP0001119_abnormal_female_reproductive1.21791058
44MP0002735_abnormal_chemical_nociception1.21760226
45MP0000350_abnormal_cell_proliferation1.21061648
46MP0002398_abnormal_bone_marrow1.20555918
47MP0002396_abnormal_hematopoietic_system1.19772547
48MP0000685_abnormal_immune_system1.15583809
49MP0004142_abnormal_muscle_tone1.15495415
50MP0001800_abnormal_humoral_immune1.14484590
51MP0009745_abnormal_behavioral_response1.14225511
52MP0002876_abnormal_thyroid_physiology1.12993737
53MP0000313_abnormal_cell_death1.12243870
54MP0003136_yellow_coat_color1.10225396
55MP0001293_anophthalmia1.09953575
56MP0000427_abnormal_hair_cycle1.09722711
57MP0004808_abnormal_hematopoietic_stem1.09494600
58MP0001919_abnormal_reproductive_system1.09255151
59MP0005220_abnormal_exocrine_pancreas1.08939996
60MP0005389_reproductive_system_phenotype1.07604190
61MP0002693_abnormal_pancreas_physiology1.07466201
62MP0001986_abnormal_taste_sensitivity1.07298502
63MP0006036_abnormal_mitochondrial_physio1.06128369
64MP0005551_abnormal_eye_electrophysiolog1.06006616
65MP0000358_abnormal_cell_content/1.05995877
66MP0000015_abnormal_ear_pigmentation1.05309049
67MP0005647_abnormal_sex_gland1.05103447
68MP0004381_abnormal_hair_follicle1.05023260
69MP0000703_abnormal_thymus_morphology1.05003749
70MP0000631_abnormal_neuroendocrine_gland1.04656884
71MP0001764_abnormal_homeostasis1.02961419
72MP0000566_synostosis1.00915189
73MP0005380_embryogenesis_phenotype1.00635913
74MP0001672_abnormal_embryogenesis/_devel1.00635913
75MP0001348_abnormal_lacrimal_gland1.00277572
76MP0006035_abnormal_mitochondrial_morpho1.00052758
77MP0001697_abnormal_embryo_size0.98793630
78MP0001545_abnormal_hematopoietic_system0.97837488
79MP0005397_hematopoietic_system_phenotyp0.97837488
80MP0004133_heterotaxia0.97052895
81MP0009697_abnormal_copulation0.96915669
82MP0010307_abnormal_tumor_latency0.96848343
83MP0002638_abnormal_pupillary_reflex0.96780296
84MP0003699_abnormal_female_reproductive0.96462706
85MP0003787_abnormal_imprinting0.96265825
86MP0005075_abnormal_melanosome_morpholog0.95507534
87MP0002722_abnormal_immune_system0.94308108
88MP0001944_abnormal_pancreas_morphology0.91762791
89MP0005646_abnormal_pituitary_gland0.90766448
90MP0002429_abnormal_blood_cell0.90180683
91MP0003123_paternal_imprinting0.90102588
92MP0005409_darkened_coat_color0.90101930
93MP0003315_abnormal_perineum_morphology0.88205441
94MP0002723_abnormal_immune_serum0.86325672
95MP0002085_abnormal_embryonic_tissue0.85193071
96MP0001661_extended_life_span0.84216196
97MP0003878_abnormal_ear_physiology0.83872413
98MP0005377_hearing/vestibular/ear_phenot0.83872413
99MP0003984_embryonic_growth_retardation0.83140758
100MP0002080_prenatal_lethality0.82656269
101MP0002019_abnormal_tumor_incidence0.82221740
102MP0000716_abnormal_immune_system0.82157542
103MP0002132_abnormal_respiratory_system0.82126757
104MP0005387_immune_system_phenotype0.81096788
105MP0001790_abnormal_immune_system0.81096788
106MP0002420_abnormal_adaptive_immunity0.81047149
107MP0001346_abnormal_lacrimal_gland0.80196744
108MP0001905_abnormal_dopamine_level0.79300253
109MP0002733_abnormal_thermal_nociception0.78235095
110MP0003806_abnormal_nucleotide_metabolis0.78139870
111MP0001819_abnormal_immune_cell0.77851599
112MP0005174_abnormal_tail_pigmentation0.77583478
113MP0002088_abnormal_embryonic_growth/wei0.76704553
114MP0003890_abnormal_embryonic-extraembry0.76527510
115MP0000371_diluted_coat_color0.75976719
116MP0002928_abnormal_bile_duct0.75597262
117MP0002272_abnormal_nervous_system0.75395033
118MP0002084_abnormal_developmental_patter0.74584863
119MP0002234_abnormal_pharynx_morphology0.74408289
120MP0005000_abnormal_immune_tolerance0.73310289
121MP0002736_abnormal_nociception_after0.73091190
122MP0002064_seizures0.72734365
123MP0005266_abnormal_metabolism0.72728955
124MP0005423_abnormal_somatic_nervous0.72640289
125MP0003186_abnormal_redox_activity0.70784970
126MP0004197_abnormal_fetal_growth/weight/0.68337240
127MP0002095_abnormal_skin_pigmentation0.66043947
128MP0003567_abnormal_fetal_cardiomyocyte0.66009573
129MP0002009_preneoplasia0.61198699
130MP0005408_hypopigmentation0.59604393
131MP0001188_hyperpigmentation0.58404929
132MP0003119_abnormal_digestive_system0.57936458
133MP0008789_abnormal_olfactory_epithelium0.55736731
134MP0000490_abnormal_crypts_of0.54629639
135MP0003936_abnormal_reproductive_system0.53684120
136MP0002938_white_spotting0.53339714
137MP0002269_muscular_atrophy0.53180054
138MP0003115_abnormal_respiratory_system0.52451378
139MP0002282_abnormal_trachea_morphology0.51244226
140MP0000678_abnormal_parathyroid_gland0.50561039
141MP0001529_abnormal_vocalization0.50433648
142MP0003861_abnormal_nervous_system0.49413718
143MP0003763_abnormal_thymus_physiology0.48567795
144MP0002086_abnormal_extraembryonic_tissu0.47388808
145MP0002075_abnormal_coat/hair_pigmentati0.47088846
146MP0003121_genomic_imprinting0.46856051
147MP0004782_abnormal_surfactant_physiolog0.46810997
148MP0005394_taste/olfaction_phenotype0.46361308
149MP0005499_abnormal_olfactory_system0.46361308
150MP0005376_homeostasis/metabolism_phenot0.44555694
151MP0003943_abnormal_hepatobiliary_system0.43021457
152MP0009278_abnormal_bone_marrow0.42917705
153MP0002092_abnormal_eye_morphology0.42709245
154MP0003937_abnormal_limbs/digits/tail_de0.41470862
155MP0001186_pigmentation_phenotype0.40779441
156MP0000689_abnormal_spleen_morphology0.40562703
157MP0002751_abnormal_autonomic_nervous0.39124225

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.64402468
2Absent/shortened dynein arms (HP:0200106)8.28760981
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.28760981
4Abnormal respiratory motile cilium morphology (HP:0005938)6.80455210
5Abnormal respiratory epithelium morphology (HP:0012253)6.80455210
6Abnormal respiratory motile cilium physiology (HP:0012261)6.42240511
7Rhinitis (HP:0012384)5.84387518
8Chronic bronchitis (HP:0004469)5.30733765
9Abnormal ciliary motility (HP:0012262)4.99302415
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19589423
11Infertility (HP:0000789)4.19259344
12Birth length less than 3rd percentile (HP:0003561)3.86194780
13Chromsome breakage (HP:0040012)3.82068686
14Nasal polyposis (HP:0100582)3.57964204
15Nephronophthisis (HP:0000090)3.54239711
16Bronchiectasis (HP:0002110)3.41512354
17Abnormal spermatogenesis (HP:0008669)3.40998821
18Impulsivity (HP:0100710)3.34747125
19Bronchitis (HP:0012387)2.96397321
20Abnormality of the nasal mucosa (HP:0000433)2.91612857
21Increased serum lactate (HP:0002151)2.91469792
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87511709
23Molar tooth sign on MRI (HP:0002419)2.87405467
24Abnormality of midbrain morphology (HP:0002418)2.87405467
25Meckel diverticulum (HP:0002245)2.86535379
26Abnormality of the anterior horn cell (HP:0006802)2.85893481
27Degeneration of anterior horn cells (HP:0002398)2.85893481
28Breast hypoplasia (HP:0003187)2.83241786
29Lipid accumulation in hepatocytes (HP:0006561)2.81424135
30Abnormality of the ileum (HP:0001549)2.80785327
31Medial flaring of the eyebrow (HP:0010747)2.79732949
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.74563598
33Abnormality of the preputium (HP:0100587)2.72446386
34Azoospermia (HP:0000027)2.71231669
35Gonadotropin excess (HP:0000837)2.68793501
36Progressive microcephaly (HP:0000253)2.67634092
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.62642602
38Increased CSF lactate (HP:0002490)2.61303698
39Mitochondrial inheritance (HP:0001427)2.61169992
40Abnormality of cells of the erythroid lineage (HP:0012130)2.60466617
41Supernumerary spleens (HP:0009799)2.59631789
42Male infertility (HP:0003251)2.58481458
43Increased intramyocellular lipid droplets (HP:0012240)2.57422679
44Type II lissencephaly (HP:0007260)2.56106917
45Abnormality of the renal medulla (HP:0100957)2.55279566
46Hepatocellular necrosis (HP:0001404)2.54773685
47Aplastic anemia (HP:0001915)2.54510362
483-Methylglutaconic aciduria (HP:0003535)2.53596276
49Attenuation of retinal blood vessels (HP:0007843)2.53592962
50Microvesicular hepatic steatosis (HP:0001414)2.51507167
51Increased hepatocellular lipid droplets (HP:0006565)2.50146809
52Tongue fasciculations (HP:0001308)2.47544648
53Increased muscle lipid content (HP:0009058)2.45023122
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44142936
55Sloping forehead (HP:0000340)2.41022931
56Postaxial foot polydactyly (HP:0001830)2.39096010
57Nephroblastoma (Wilms tumor) (HP:0002667)2.37651150
58Abnormality of chromosome stability (HP:0003220)2.36740139
59Cerebral hypomyelination (HP:0006808)2.35493217
60Pancreatic cysts (HP:0001737)2.35033575
61Acute encephalopathy (HP:0006846)2.34828216
62Abnormal rod and cone electroretinograms (HP:0008323)2.31905604
63Ectopic kidney (HP:0000086)2.30340655
64Hepatic necrosis (HP:0002605)2.26890915
6511 pairs of ribs (HP:0000878)2.26613789
66Abnormal mitochondria in muscle tissue (HP:0008316)2.25123461
67Recurrent sinusitis (HP:0011108)2.24453594
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23906356
69Abnormality of alanine metabolism (HP:0010916)2.23906356
70Hyperalaninemia (HP:0003348)2.23906356
71Acute necrotizing encephalopathy (HP:0006965)2.21879620
72Tubulointerstitial nephritis (HP:0001970)2.20615325
73Abnormality of DNA repair (HP:0003254)2.18511485
74Nephrogenic diabetes insipidus (HP:0009806)2.17886649
75Congenital stationary night blindness (HP:0007642)2.15455760
76Abnormality of the lower motor neuron (HP:0002366)2.15241918
77Premature ovarian failure (HP:0008209)2.14198347
78Duplicated collecting system (HP:0000081)2.14016339
79Pancreatic fibrosis (HP:0100732)2.13419798
80Absent thumb (HP:0009777)2.12354106
81Abnormality of T cell physiology (HP:0011840)2.12266307
82Panhypogammaglobulinemia (HP:0003139)2.11386964
83Facial cleft (HP:0002006)2.11349720
84Abnormality of the carotid arteries (HP:0005344)2.10947032
85Embryonal renal neoplasm (HP:0011794)2.09741031
86Lactic acidosis (HP:0003128)2.09226133
87Carpal bone hypoplasia (HP:0001498)2.08760634
88Muscle fibrillation (HP:0010546)2.08278050
89True hermaphroditism (HP:0010459)2.08132613
90Microretrognathia (HP:0000308)2.07940488
91Recurrent otitis media (HP:0000403)2.06178869
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04752737
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04752737
94Limb hypertonia (HP:0002509)2.02036127
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99369065
96Testicular atrophy (HP:0000029)1.98050497
97Rectal fistula (HP:0100590)1.97668970
98Rectovaginal fistula (HP:0000143)1.97668970
99IgG deficiency (HP:0004315)1.97408983
100Squamous cell carcinoma (HP:0002860)1.95454497
101Abnormality of the pons (HP:0007361)1.93709947
102Duodenal stenosis (HP:0100867)1.93708931
103Small intestinal stenosis (HP:0012848)1.93708931
104Chronic hepatic failure (HP:0100626)1.92995043
105Severe visual impairment (HP:0001141)1.92376876
106Ketoacidosis (HP:0001993)1.92173051
107Congenital primary aphakia (HP:0007707)1.92043847
108Clubbing of toes (HP:0100760)1.91693194
109Albinism (HP:0001022)1.90833360
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89496898
111Constricted visual fields (HP:0001133)1.89117979
112Visual hallucinations (HP:0002367)1.88489711
113Gait imbalance (HP:0002141)1.86143818
114Abnormal drinking behavior (HP:0030082)1.86112420
115Polydipsia (HP:0001959)1.86112420
116Abnormality of the renal collecting system (HP:0004742)1.84858608
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84782213
118Optic disc pallor (HP:0000543)1.84735027
119Impaired proprioception (HP:0010831)1.83097528
120Ketosis (HP:0001946)1.82924569
121Progressive muscle weakness (HP:0003323)1.82259967
122Tubular atrophy (HP:0000092)1.82052264
123Hypoplasia of the pons (HP:0012110)1.81757362
124Progressive macrocephaly (HP:0004481)1.81706532
125Myelodysplasia (HP:0002863)1.81272136
126Dyschromatopsia (HP:0007641)1.80126374
127Hypoplasia of the radius (HP:0002984)1.78827173
128Median cleft lip (HP:0000161)1.78713636
129Bone marrow hypocellularity (HP:0005528)1.78293280
130Cerebellar dysplasia (HP:0007033)1.77804950
131CNS hypomyelination (HP:0003429)1.77603060
132Patellar aplasia (HP:0006443)1.77275549
133Pendular nystagmus (HP:0012043)1.76730536
134Lissencephaly (HP:0001339)1.75630483
135Progressive inability to walk (HP:0002505)1.75316238
136Homocystinuria (HP:0002156)1.75106959
137Abnormality of homocysteine metabolism (HP:0010919)1.75106959
138Aplasia/Hypoplasia of the lens (HP:0008063)1.74498950
139Clumsiness (HP:0002312)1.74406575
140Exercise intolerance (HP:0003546)1.74194927
141Poor eye contact (HP:0000817)1.74147054
142Poor coordination (HP:0002370)1.73526981
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73482317
144Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73047951
145Congenital hepatic fibrosis (HP:0002612)1.71359217
146Absent radius (HP:0003974)1.70440145
147Male pseudohermaphroditism (HP:0000037)1.68159182
148Abnormal lung lobation (HP:0002101)1.68060916
149Intestinal fistula (HP:0100819)1.66454346
150Respiratory difficulties (HP:0002880)1.66393938
151Cleft eyelid (HP:0000625)1.66253225
152Mesangial abnormality (HP:0001966)1.65899153
153Progressive external ophthalmoplegia (HP:0000590)1.65357477
154Triphalangeal thumb (HP:0001199)1.65031916
155Sclerocornea (HP:0000647)1.64897643
156Vaginal fistula (HP:0004320)1.62627930
157Fibular hypoplasia (HP:0003038)1.62259678
158Aganglionic megacolon (HP:0002251)1.62244396
159Aplasia/Hypoplasia of the patella (HP:0006498)1.62093798
160Oral leukoplakia (HP:0002745)1.61293907
161Aplasia/Hypoplasia affecting the retina (HP:0008061)1.60953392
162Abnormal number of erythroid precursors (HP:0012131)1.58188154
163Sensory axonal neuropathy (HP:0003390)1.57743706
164Pancytopenia (HP:0001876)1.57536765
165Retinal dysplasia (HP:0007973)1.57195198
166Renal Fanconi syndrome (HP:0001994)1.57175799
167Postaxial hand polydactyly (HP:0001162)1.56398921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.56003962
2PDK45.56003962
3WEE13.60003767
4PDK23.51564242
5TESK13.09565829
6CDC72.89355408
7NEK22.50047455
8BUB12.43685446
9MAP4K22.42457224
10ICK2.35466042
11VRK22.29709858
12SRPK12.26364306
13FRK2.19398755
14EEF2K2.06846850
15DYRK31.98647015
16AKT31.97648417
17PRKD31.97426666
18PLK41.83561658
19SIK21.75797502
20TAOK31.75434608
21ACVR1B1.74353967
22STK161.74126344
23BRSK21.71367680
24TTK1.71268858
25MAPKAPK51.57759120
26PLK11.57015589
27CHEK21.56624993
28NME11.55567759
29ATR1.51938762
30CDK71.45247751
31VRK11.44920326
32ZAK1.44276444
33CCNB11.42697255
34MKNK11.40463301
35PASK1.40401925
36EIF2AK11.39953846
37PNCK1.30254873
38PINK11.28068838
39CAMKK21.27025396
40YES11.24943144
41IKBKB1.24304964
42INSRR1.21783392
43TESK21.21530370
44WNK41.20944725
45NME21.20301003
46MAPK151.20169727
47TXK1.19645790
48MAP4K11.18937357
49CDK121.16788050
50BRSK11.14218791
51STK391.13455668
52MAPK111.09802467
53DYRK1B1.09623746
54PRKCI1.08357001
55BMPR1B1.08352052
56MKNK21.07491899
57TAF11.07216807
58PLK31.04247126
59RAF11.04069761
60RPS6KB21.00143556
61CHEK10.99861153
62SCYL20.99479146
63MAPKAPK30.98353018
64MUSK0.96855523
65PBK0.96687783
66SMG10.95956133
67STK30.92409744
68AURKA0.91521214
69MAPK130.91132506
70EIF2AK30.90684305
71PRKCQ0.90278030
72TRIM280.88339431
73TAOK20.88238600
74STK40.85531590
75AURKB0.83359915
76CAMK1D0.82106918
77TSSK60.81540793
78DAPK10.80639970
79FLT30.78547391
80STK100.77597419
81TEC0.75229974
82ADRBK20.74810875
83STK38L0.72599793
84ATM0.72541260
85EIF2AK20.71869566
86PIM10.69691771
87PTK2B0.67783616
88MAP3K40.67781810
89CSNK1G30.67016602
90IRAK30.65950540
91CDK40.65871232
92BRD40.64086629
93NEK60.62792162
94DYRK20.61246421
95CSNK2A10.60641635
96MAP2K70.59952236
97WNK30.57550359
98CDK20.53960514
99BCKDK0.53849383
100CSNK2A20.53528053
101IKBKE0.53329247
102MST40.52535301
103MAP2K60.52045046
104CLK10.50125302
105CHUK0.49962379
106MAP3K110.49111291
107PHKG10.48829743
108PHKG20.48829743
109CSNK1G20.48214974
110PIK3CG0.48051004
111KIT0.47993877
112NUAK10.47728164
113TRPM70.45607830
114SYK0.44405029
115HIPK20.44376128
116CDK10.43922883
117PIM20.41869567
118CSNK1G10.41562724
119MAP2K20.41241306
120STK380.40566738
121MAP3K60.40437205
122ITK0.39443410
123STK240.39339002
124SIK30.39324233
125CAMKK10.39287267
126MAP3K140.38889980
127PRKAA20.38808942
128CDK80.37047829
129TLK10.35929150
130NEK10.35226545
131PAK10.30178719
132PRPF4B0.29872385
133BTK0.29631026
134RPS6KA40.28967057
135RPS6KB10.27797771
136CDK30.27430729
137CSF1R0.26550177
138WNK10.24612961
139MARK30.22345211
140ERBB30.21965214
141GSK3B0.19528422
142UHMK10.19079895
143BRAF0.18063337
144RPS6KA50.17846975
145PRKAA10.17246459
146MAPK140.16936433
147PRKDC0.13783071
148TIE10.13198031
149GRK10.12808762

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42387918
2Mismatch repair_Homo sapiens_hsa034303.66523595
3Homologous recombination_Homo sapiens_hsa034403.57801147
4Basal transcription factors_Homo sapiens_hsa030223.46304775
5Fanconi anemia pathway_Homo sapiens_hsa034603.38044473
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33156005
7Vitamin B6 metabolism_Homo sapiens_hsa007502.76184792
8RNA polymerase_Homo sapiens_hsa030202.74304556
9Base excision repair_Homo sapiens_hsa034102.72910365
10Nucleotide excision repair_Homo sapiens_hsa034202.67460582
11Spliceosome_Homo sapiens_hsa030402.66362279
12RNA transport_Homo sapiens_hsa030132.64151789
13Cell cycle_Homo sapiens_hsa041102.38983054
14Pyrimidine metabolism_Homo sapiens_hsa002402.36010433
15Primary immunodeficiency_Homo sapiens_hsa053402.32180536
16Proteasome_Homo sapiens_hsa030501.96495365
17Selenocompound metabolism_Homo sapiens_hsa004501.89135185
18One carbon pool by folate_Homo sapiens_hsa006701.89123644
19mRNA surveillance pathway_Homo sapiens_hsa030151.79908458
20Non-homologous end-joining_Homo sapiens_hsa034501.77967431
21Ribosome_Homo sapiens_hsa030101.74669270
22RNA degradation_Homo sapiens_hsa030181.72958908
23Linoleic acid metabolism_Homo sapiens_hsa005911.69881074
24Purine metabolism_Homo sapiens_hsa002301.66419731
25Huntingtons disease_Homo sapiens_hsa050161.66292474
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.62313892
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58820155
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56341347
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45353456
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42888150
31Pyruvate metabolism_Homo sapiens_hsa006201.41411183
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.39845469
33Pentose phosphate pathway_Homo sapiens_hsa000301.39842282
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33520409
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27533849
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24952224
37p53 signaling pathway_Homo sapiens_hsa041151.23272004
38Butanoate metabolism_Homo sapiens_hsa006501.22855816
39Phototransduction_Homo sapiens_hsa047441.22320275
40Nitrogen metabolism_Homo sapiens_hsa009101.11602360
41Oocyte meiosis_Homo sapiens_hsa041141.08086210
42Arachidonic acid metabolism_Homo sapiens_hsa005901.05432673
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01863648
44Propanoate metabolism_Homo sapiens_hsa006401.00650372
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95189246
46Biosynthesis of amino acids_Homo sapiens_hsa012300.92875823
47Asthma_Homo sapiens_hsa053100.92039255
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86134280
49Systemic lupus erythematosus_Homo sapiens_hsa053220.86019511
50Parkinsons disease_Homo sapiens_hsa050120.84601076
51N-Glycan biosynthesis_Homo sapiens_hsa005100.82723623
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82601671
53Glutathione metabolism_Homo sapiens_hsa004800.82507929
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82391326
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81622206
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77423173
57Allograft rejection_Homo sapiens_hsa053300.76971671
58Type I diabetes mellitus_Homo sapiens_hsa049400.76043117
59Herpes simplex infection_Homo sapiens_hsa051680.74745794
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74646995
61Oxidative phosphorylation_Homo sapiens_hsa001900.74392221
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74231291
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74208127
64Fatty acid biosynthesis_Homo sapiens_hsa000610.72712229
65Regulation of autophagy_Homo sapiens_hsa041400.71879279
66Protein export_Homo sapiens_hsa030600.70231386
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70199850
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69984291
69Metabolic pathways_Homo sapiens_hsa011000.68898641
70Epstein-Barr virus infection_Homo sapiens_hsa051690.68178714
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67678136
72Carbon metabolism_Homo sapiens_hsa012000.67394949
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61918928
74Ether lipid metabolism_Homo sapiens_hsa005650.61121612
75Antigen processing and presentation_Homo sapiens_hsa046120.60489532
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60303482
77Nicotine addiction_Homo sapiens_hsa050330.59606804
78Viral carcinogenesis_Homo sapiens_hsa052030.59039082
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.58629708
80Folate biosynthesis_Homo sapiens_hsa007900.58257059
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57847162
82Fructose and mannose metabolism_Homo sapiens_hsa000510.57670693
83Autoimmune thyroid disease_Homo sapiens_hsa053200.56823486
84T cell receptor signaling pathway_Homo sapiens_hsa046600.55878898
85Glucagon signaling pathway_Homo sapiens_hsa049220.54914067
86Legionellosis_Homo sapiens_hsa051340.54523465
87Collecting duct acid secretion_Homo sapiens_hsa049660.53205639
88Glycerolipid metabolism_Homo sapiens_hsa005610.52096336
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50239566
90Sulfur relay system_Homo sapiens_hsa041220.49965945
91Tryptophan metabolism_Homo sapiens_hsa003800.49926822
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49139034
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.44397551
94Cardiac muscle contraction_Homo sapiens_hsa042600.44374271
95Peroxisome_Homo sapiens_hsa041460.43951905
96Vitamin digestion and absorption_Homo sapiens_hsa049770.42268064
97Olfactory transduction_Homo sapiens_hsa047400.41678821
98Sphingolipid metabolism_Homo sapiens_hsa006000.40942522
99Fat digestion and absorption_Homo sapiens_hsa049750.39904887
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.39791901
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38807092
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38764903
103Dorso-ventral axis formation_Homo sapiens_hsa043200.37384820
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.36187998
105Circadian rhythm_Homo sapiens_hsa047100.35425050
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33887848
107Graft-versus-host disease_Homo sapiens_hsa053320.33517141
108Taste transduction_Homo sapiens_hsa047420.31507625
109Fatty acid elongation_Homo sapiens_hsa000620.31340442
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31264119
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30024647
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.27678342
113Sulfur metabolism_Homo sapiens_hsa009200.27140978
114Lysine degradation_Homo sapiens_hsa003100.26493441
115Alcoholism_Homo sapiens_hsa050340.26183876
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.24925585
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24617352
118Retinol metabolism_Homo sapiens_hsa008300.24103698
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23627786
120HTLV-I infection_Homo sapiens_hsa051660.23098724
121Alzheimers disease_Homo sapiens_hsa050100.23098011
122Other glycan degradation_Homo sapiens_hsa005110.22096755
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21789382
124Apoptosis_Homo sapiens_hsa042100.21400477
125Arginine and proline metabolism_Homo sapiens_hsa003300.19287098
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19037735
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18987167
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16547870
129Basal cell carcinoma_Homo sapiens_hsa052170.15936309
130Chemical carcinogenesis_Homo sapiens_hsa052040.15228690
131Galactose metabolism_Homo sapiens_hsa000520.14674455
132Measles_Homo sapiens_hsa051620.14227209
133ABC transporters_Homo sapiens_hsa020100.12003134
134Hedgehog signaling pathway_Homo sapiens_hsa043400.11949724

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