PLEKHA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.53174554
2central nervous system myelination (GO:0022010)9.53174554
3ensheathment of neurons (GO:0007272)6.96163846
4axon ensheathment (GO:0008366)6.96163846
5myelination (GO:0042552)6.89644388
6fatty acid elongation (GO:0030497)5.97943102
7negative regulation of neurotransmitter secretion (GO:0046929)5.55412646
8long-chain fatty acid biosynthetic process (GO:0042759)5.16227523
9apical protein localization (GO:0045176)4.71119383
10oligodendrocyte differentiation (GO:0048709)4.62876067
11virion attachment to host cell (GO:0019062)4.61332901
12adhesion of symbiont to host cell (GO:0044650)4.61332901
13asymmetric protein localization (GO:0008105)4.50552753
14negative regulation of neurotransmitter transport (GO:0051589)4.40620887
15peptidyl-tyrosine autophosphorylation (GO:0038083)4.38322490
16presynaptic membrane assembly (GO:0097105)4.33919740
17glycerophospholipid catabolic process (GO:0046475)4.27044120
18photoreceptor cell differentiation (GO:0046530)4.24130342
19eye photoreceptor cell differentiation (GO:0001754)4.24130342
20presynaptic membrane organization (GO:0097090)4.19321460
21myelin maintenance (GO:0043217)4.18751223
22negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.15067881
23myelination in peripheral nervous system (GO:0022011)4.02990587
24peripheral nervous system axon ensheathment (GO:0032292)4.02990587
25astrocyte development (GO:0014002)3.91433619
26substantia nigra development (GO:0021762)3.88907606
27transmission of nerve impulse (GO:0019226)3.87601579
28regulation of collateral sprouting (GO:0048670)3.79768625
29response to redox state (GO:0051775)3.77742893
30creatine metabolic process (GO:0006600)3.72313456
31L-amino acid import (GO:0043092)3.70349794
32neuron cell-cell adhesion (GO:0007158)3.69797384
33positive regulation of action potential (GO:0045760)3.68694417
34negative regulation of protein localization to cell surface (GO:2000009)3.58864973
35cholesterol biosynthetic process (GO:0006695)3.56940133
36establishment of mitochondrion localization (GO:0051654)3.51093986
37import into cell (GO:0098657)3.41066802
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38883766
39gamma-aminobutyric acid transport (GO:0015812)3.38201409
40adhesion of symbiont to host (GO:0044406)3.38145578
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.36897938
42negative regulation of axonogenesis (GO:0050771)3.35350727
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30784006
44cellular response to epinephrine stimulus (GO:0071872)3.29425609
45neuronal ion channel clustering (GO:0045161)3.29330822
46cellular response to hepatocyte growth factor stimulus (GO:0035729)3.29306662
47response to hepatocyte growth factor (GO:0035728)3.29306662
48behavioral response to nicotine (GO:0035095)3.26887399
49cerebral cortex radially oriented cell migration (GO:0021799)3.23402054
50limb bud formation (GO:0060174)3.23342220
51protein palmitoylation (GO:0018345)3.18794321
52negative regulation of JUN kinase activity (GO:0043508)3.15632475
53neuronal action potential propagation (GO:0019227)3.07189712
54adult walking behavior (GO:0007628)3.06319548
55magnesium ion transport (GO:0015693)3.06207751
56cerebellar granule cell differentiation (GO:0021707)3.04556511
57sterol biosynthetic process (GO:0016126)3.03306708
58establishment of protein localization to Golgi (GO:0072600)3.02201009
59negative regulation of axon extension (GO:0030517)3.01962842
60response to lipoprotein particle (GO:0055094)3.00931911
61peripheral nervous system development (GO:0007422)2.91413746
62ear development (GO:0043583)2.89138704
63amino acid import (GO:0043090)2.88416362
64nerve growth factor signaling pathway (GO:0038180)2.87079307
65membrane assembly (GO:0071709)2.86910781
66activated T cell proliferation (GO:0050798)2.86431352
67long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.86160828
68response to epinephrine (GO:0071871)2.85662697
69cellular response to monoamine stimulus (GO:0071868)2.83018334
70cellular response to catecholamine stimulus (GO:0071870)2.83018334
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81808211
72response to pheromone (GO:0019236)2.81625021
73synaptic vesicle docking involved in exocytosis (GO:0016081)2.80330181
74isoprenoid biosynthetic process (GO:0008299)2.79990131
75positive regulation of actin filament depolymerization (GO:0030836)2.76927482
76positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.76679336
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75432960
78neurotransmitter catabolic process (GO:0042135)2.73134007
79atrial cardiac muscle cell action potential (GO:0086014)2.71975298
80glycosylceramide metabolic process (GO:0006677)2.71893165
81serotonin metabolic process (GO:0042428)2.71224923
82positive regulation of neurological system process (GO:0031646)2.69503407
83histone H2B ubiquitination (GO:0033523)2.68612230
84neural nucleus development (GO:0048857)2.68194295
85reflex (GO:0060004)2.68088427
86protein targeting to Golgi (GO:0000042)2.67356776
87neuron remodeling (GO:0016322)2.66914695
88Golgi to plasma membrane protein transport (GO:0043001)2.66618374
89macroautophagy (GO:0016236)2.66271617
90nephron tubule morphogenesis (GO:0072078)2.64797592
91nephron epithelium morphogenesis (GO:0072088)2.64797592
92kidney morphogenesis (GO:0060993)2.64128803
93primary amino compound metabolic process (GO:1901160)2.63056611
94tryptophan catabolic process (GO:0006569)2.62595193
95indole-containing compound catabolic process (GO:0042436)2.62595193
96indolalkylamine catabolic process (GO:0046218)2.62595193
97protein localization to endosome (GO:0036010)2.62171042
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61314446
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60750245
100long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.58759634
101response to catecholamine (GO:0071869)2.58183455
102response to monoamine (GO:0071867)2.58183455
103interleukin-6-mediated signaling pathway (GO:0070102)2.57872126
104membrane tubulation (GO:0097320)2.57757403
105leukocyte migration involved in inflammatory response (GO:0002523)2.56552185
106glial cell development (GO:0021782)2.56393934
107positive regulation of glial cell differentiation (GO:0045687)2.56358964
108Rap protein signal transduction (GO:0032486)2.56178138
109membrane depolarization during action potential (GO:0086010)2.55831372
110axon development (GO:0061564)2.54721342
111dendrite morphogenesis (GO:0048813)2.53532708
112neuron recognition (GO:0008038)2.52445211
113protein K11-linked deubiquitination (GO:0035871)2.51986139
114nucleotide transmembrane transport (GO:1901679)2.51907615
115regulation of hippo signaling (GO:0035330)2.51759063
116retinal cone cell development (GO:0046549)2.51565319
117peristalsis (GO:0030432)2.50359271
118amyloid precursor protein metabolic process (GO:0042982)2.49848751
119peptidyl-cysteine modification (GO:0018198)2.49173744
120renal tubule morphogenesis (GO:0061333)2.48091307
121neuronal action potential (GO:0019228)2.47223970
122nucleobase catabolic process (GO:0046113)2.47123799
123transepithelial transport (GO:0070633)2.47049614
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47049473
125cyclic nucleotide catabolic process (GO:0009214)2.46705447
126proline transport (GO:0015824)2.45881707
127protein localization to synapse (GO:0035418)2.45604761
128indolalkylamine metabolic process (GO:0006586)2.45298846
129negative regulation of execution phase of apoptosis (GO:1900118)2.44578796
130actin filament depolymerization (GO:0030042)2.44575939
131positive regulation of sodium ion transmembrane transport (GO:1902307)2.43682126
132pyrimidine nucleobase catabolic process (GO:0006208)2.42704920
133retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42285443
134Golgi to endosome transport (GO:0006895)2.41602152
135vocalization behavior (GO:0071625)2.41079224
136organ growth (GO:0035265)2.40675010
137negative regulation of inclusion body assembly (GO:0090084)2.39974461
138glial cell differentiation (GO:0010001)2.39709547
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39686397
140protein localization to Golgi apparatus (GO:0034067)2.39611956
141negative regulation of exocytosis (GO:0045920)2.39012306
142gamma-aminobutyric acid signaling pathway (GO:0007214)2.38363718
143fatty-acyl-CoA biosynthetic process (GO:0046949)2.37507873
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37428155
145action potential (GO:0001508)2.37154016
146neurotransmitter-gated ion channel clustering (GO:0072578)2.35808750
147C4-dicarboxylate transport (GO:0015740)2.35604143
148parturition (GO:0007567)2.34687935
149glutamate secretion (GO:0014047)2.32559620
150cochlea development (GO:0090102)2.32365299
151synapse assembly (GO:0007416)2.32210526
152cerebellar Purkinje cell differentiation (GO:0021702)2.32019964
153indole-containing compound metabolic process (GO:0042430)2.30797344
154insulin secretion (GO:0030073)2.30294525
155startle response (GO:0001964)2.30111423
156vesicle transport along microtubule (GO:0047496)2.29451639
157detection of light stimulus involved in sensory perception (GO:0050962)2.29185379
158detection of light stimulus involved in visual perception (GO:0050908)2.29185379
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28969644
160dendritic spine morphogenesis (GO:0060997)2.28741516
161multicellular organismal signaling (GO:0035637)2.28144467
162kynurenine metabolic process (GO:0070189)2.28081237
163signal peptide processing (GO:0006465)2.27909148
164positive regulation of glycolytic process (GO:0045821)2.26123706
165nonmotile primary cilium assembly (GO:0035058)2.25900406
166regulation of neurotransmitter uptake (GO:0051580)2.25573836
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.24705948
168glutamate receptor signaling pathway (GO:0007215)2.24626372
169protein polyglutamylation (GO:0018095)2.24575073
170neural tube formation (GO:0001841)2.23359604
171positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.23025963
172behavioral response to ethanol (GO:0048149)2.22340340
173cAMP catabolic process (GO:0006198)2.21707649
174regulation of sarcomere organization (GO:0060297)2.19476279
175negative regulation of sodium ion transport (GO:0010766)2.18692130
176postsynaptic membrane organization (GO:0001941)2.18410494
177neurofilament cytoskeleton organization (GO:0060052)2.16740225
178auditory behavior (GO:0031223)2.16628237
179negative regulation of dendrite development (GO:2000171)2.16346803
180calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15700796
181synaptic vesicle maturation (GO:0016188)2.15036962
182regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.14839522
183cell communication involved in cardiac conduction (GO:0086065)2.14788949
184regulation of heart rate by cardiac conduction (GO:0086091)2.14527668
185fucose catabolic process (GO:0019317)2.14099585
186L-fucose metabolic process (GO:0042354)2.14099585
187L-fucose catabolic process (GO:0042355)2.14099585
188interkinetic nuclear migration (GO:0022027)2.13851207
189bundle of His cell to Purkinje myocyte communication (GO:0086069)2.12752849
190regulation of sodium ion transmembrane transporter activity (GO:2000649)2.12597740
191regulation of hexokinase activity (GO:1903299)2.12173059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44789941
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.47598509
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34115063
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32411092
5TAF15_26573619_Chip-Seq_HEK293_Human2.26530934
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25443923
7ZNF274_21170338_ChIP-Seq_K562_Hela2.23103548
8EZH2_22144423_ChIP-Seq_EOC_Human2.18268070
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.12310860
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03105554
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03105554
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03051490
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99155519
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98354675
15IGF1R_20145208_ChIP-Seq_DFB_Human1.97813391
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97463401
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94643457
18DROSHA_22980978_ChIP-Seq_HELA_Human1.86346952
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85878251
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.82301087
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.82219912
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81242429
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80439858
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.78807489
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76293529
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.75608860
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.73803300
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71963387
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70717057
30AR_21572438_ChIP-Seq_LNCaP_Human1.69413276
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67976968
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.67943385
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66600832
34ER_23166858_ChIP-Seq_MCF-7_Human1.66057836
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.65678164
36VDR_22108803_ChIP-Seq_LS180_Human1.63967994
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62378638
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54056223
39EWS_26573619_Chip-Seq_HEK293_Human1.53847511
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.53802134
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53706705
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53690826
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51256418
44BCAT_22108803_ChIP-Seq_LS180_Human1.50256087
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48191441
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48104630
47AR_25329375_ChIP-Seq_VCAP_Human1.47206128
48* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44577521
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.44478950
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44162771
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42952987
52FUS_26573619_Chip-Seq_HEK293_Human1.42931539
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42668146
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42316930
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37845762
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36562575
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.36492916
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34215428
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33728082
60CBP_20019798_ChIP-Seq_JUKART_Human1.33728082
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33610729
62* P300_19829295_ChIP-Seq_ESCs_Human1.33538521
63REST_21632747_ChIP-Seq_MESCs_Mouse1.33217521
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31926548
65STAT3_23295773_ChIP-Seq_U87_Human1.30766750
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30664984
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.30044755
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.29915719
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.27249306
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25394734
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25093905
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24866800
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24866800
74TCF4_22108803_ChIP-Seq_LS180_Human1.24120721
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23906600
76SMAD4_21799915_ChIP-Seq_A2780_Human1.21953175
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18392851
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18229615
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.17452637
80AHR_22903824_ChIP-Seq_MCF-7_Human1.17338230
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16147407
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.15363144
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.14905511
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14865173
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13568118
86RNF2_27304074_Chip-Seq_NSC_Mouse1.13282276
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12627366
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.11386602
89* TCF4_23295773_ChIP-Seq_U87_Human1.11204315
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10854448
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10663150
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.10562862
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10364333
94P53_22387025_ChIP-Seq_ESCs_Mouse1.10066004
95* CDX2_22108803_ChIP-Seq_LS180_Human1.08341225
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.08303705
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07788225
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.07626956
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07570133
100KDM2B_26808549_Chip-Seq_REH_Human1.07297440
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06287572
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06287572
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.05478968
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05466976
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05463416
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.05370741
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.05291407
108NANOG_19829295_ChIP-Seq_ESCs_Human1.04672316
109SOX2_19829295_ChIP-Seq_ESCs_Human1.04672316
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03161310
111TBL1_22424771_ChIP-Seq_293T_Human1.02932836
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02914503
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02820241
114TP53_18474530_ChIP-ChIP_U2OS_Human1.02482491
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01483077
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00483652
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.00265795
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99543369
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98944754
120TP53_16413492_ChIP-PET_HCT116_Human0.96379483
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96179704
122RUNX2_22187159_ChIP-Seq_PCA_Human0.96000053
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.94642990
124P300_18555785_Chip-Seq_ESCs_Mouse0.94426657
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94391688
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93840526
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92680276
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92631181
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91065322
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.90845442
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.90485153
132SOX9_26525672_Chip-Seq_HEART_Mouse0.90074430
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89721781
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.88411616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.04423592
2MP0000569_abnormal_digit_pigmentation4.04894506
3MP0003880_abnormal_central_pattern3.97750454
4MP0004270_analgesia3.90522879
5MP0003195_calcinosis3.65467460
6MP0004885_abnormal_endolymph3.08885333
7MP0003690_abnormal_glial_cell2.97248296
8MP0003950_abnormal_plasma_membrane2.77307614
9MP0004859_abnormal_synaptic_plasticity2.58908802
10MP0004742_abnormal_vestibular_system2.57414392
11MP0001486_abnormal_startle_reflex2.51284606
12MP0002272_abnormal_nervous_system2.50231049
13MP0000778_abnormal_nervous_system2.46466892
14MP0001485_abnormal_pinna_reflex2.39370852
15MP0003634_abnormal_glial_cell2.39113401
16MP0005171_absent_coat_pigmentation2.35347821
17MP0003329_amyloid_beta_deposits2.31150639
18MP0002064_seizures2.26311928
19MP0003787_abnormal_imprinting2.20041011
20MP0003136_yellow_coat_color2.19307753
21MP0001529_abnormal_vocalization2.14351491
22MP0000462_abnormal_digestive_system2.11834038
23MP0009046_muscle_twitch2.07747579
24MP0001905_abnormal_dopamine_level2.00865823
25MP0003635_abnormal_synaptic_transmissio1.99315031
26MP0002229_neurodegeneration1.93068052
27MP0002734_abnormal_mechanical_nocicepti1.90747598
28MP0010386_abnormal_urinary_bladder1.86499174
29MP0003122_maternal_imprinting1.85103111
30MP0009745_abnormal_behavioral_response1.83995205
31MP0006276_abnormal_autonomic_nervous1.83021791
32MP0005409_darkened_coat_color1.81729991
33MP0002138_abnormal_hepatobiliary_system1.80202350
34MP0003632_abnormal_nervous_system1.79669579
35MP0008877_abnormal_DNA_methylation1.78127855
36MP0004142_abnormal_muscle_tone1.73708603
37MP0000427_abnormal_hair_cycle1.71894012
38MP0005551_abnormal_eye_electrophysiolog1.71170088
39MP0002876_abnormal_thyroid_physiology1.70594007
40MP0010678_abnormal_skin_adnexa1.70381835
41MP0001299_abnormal_eye_distance/1.69471617
42MP0002837_dystrophic_cardiac_calcinosis1.69182430
43MP0000383_abnormal_hair_follicle1.69147711
44MP0000955_abnormal_spinal_cord1.59973195
45MP0002882_abnormal_neuron_morphology1.57223117
46MP0001440_abnormal_grooming_behavior1.50077790
47MP0005451_abnormal_body_composition1.48069578
48MP0001984_abnormal_olfaction1.48014047
49MP0005423_abnormal_somatic_nervous1.47723294
50MP0002163_abnormal_gland_morphology1.47213346
51MP0002572_abnormal_emotion/affect_behav1.42313364
52MP0002638_abnormal_pupillary_reflex1.42183906
53MP0005379_endocrine/exocrine_gland_phen1.39541638
54MP0005646_abnormal_pituitary_gland1.37999644
55MP0001188_hyperpigmentation1.37565724
56MP0002063_abnormal_learning/memory/cond1.37487153
57MP0004924_abnormal_behavior1.36587398
58MP0005386_behavior/neurological_phenoty1.36587398
59MP0004215_abnormal_myocardial_fiber1.34666161
60MP0004043_abnormal_pH_regulation1.34135348
61MP0001963_abnormal_hearing_physiology1.34013664
62MP0002067_abnormal_sensory_capabilities1.32514719
63MP0005187_abnormal_penis_morphology1.31075056
64MP0001346_abnormal_lacrimal_gland1.30774635
65MP0002752_abnormal_somatic_nervous1.30675772
66MP0002102_abnormal_ear_morphology1.30375106
67MP0005085_abnormal_gallbladder_physiolo1.29042435
68MP0002066_abnormal_motor_capabilities/c1.28530504
69MP0002909_abnormal_adrenal_gland1.25808640
70MP0003252_abnormal_bile_duct1.24890424
71MP0004134_abnormal_chest_morphology1.24554224
72MP0006072_abnormal_retinal_apoptosis1.21895700
73MP0005623_abnormal_meninges_morphology1.21438496
74MP0004145_abnormal_muscle_electrophysio1.21406648
75MP0002928_abnormal_bile_duct1.21083694
76MP0008569_lethality_at_weaning1.19630772
77MP0004147_increased_porphyrin_level1.18535477
78MP0005174_abnormal_tail_pigmentation1.17890276
79MP0001661_extended_life_span1.16356606
80MP0000747_muscle_weakness1.16280153
81MP0003937_abnormal_limbs/digits/tail_de1.15946189
82MP0002733_abnormal_thermal_nociception1.15904886
83MP0003121_genomic_imprinting1.15649404
84MP0001970_abnormal_pain_threshold1.14454848
85MP0003890_abnormal_embryonic-extraembry1.12966349
86MP0003631_nervous_system_phenotype1.11869190
87MP0004381_abnormal_hair_follicle1.11077474
88MP0000566_synostosis1.10914872
89MP0003879_abnormal_hair_cell1.09870281
90MP0008872_abnormal_physiological_respon1.08543305
91MP0005410_abnormal_fertilization1.08295858
92MP0000604_amyloidosis1.08197551
93MP0005084_abnormal_gallbladder_morpholo1.07654286
94MP0005365_abnormal_bile_salt1.07100694
95MP0005195_abnormal_posterior_eye1.06912827
96MP0004130_abnormal_muscle_cell1.03108174
97MP0005253_abnormal_eye_physiology1.02843219
98MP0008260_abnormal_autophagy1.00154315
99MP0002152_abnormal_brain_morphology0.99972515
100MP0001348_abnormal_lacrimal_gland0.97973456
101MP0002938_white_spotting0.96290703
102MP0002184_abnormal_innervation0.95149326
103MP0010329_abnormal_lipoprotein_level0.94814601
104MP0004185_abnormal_adipocyte_glucose0.94057383
105MP0005167_abnormal_blood-brain_barrier0.92381179
106MP0002735_abnormal_chemical_nociception0.92158556
107MP0004484_altered_response_of0.91740241
108MP0001177_atelectasis0.91648848
109MP0001502_abnormal_circadian_rhythm0.90676356
110MP0002139_abnormal_hepatobiliary_system0.89973041
111MP0000026_abnormal_inner_ear0.89921841
112MP0003938_abnormal_ear_development0.89256761
113MP0003123_paternal_imprinting0.87306613
114MP0009780_abnormal_chondrocyte_physiolo0.87207793
115MP0000647_abnormal_sebaceous_gland0.87074348
116MP0001756_abnormal_urination0.86408353
117MP0002822_catalepsy0.85720764
118MP0000013_abnormal_adipose_tissue0.85427089
119MP0003283_abnormal_digestive_organ0.85181460
120MP0000762_abnormal_tongue_morphology0.83708414
121MP0003633_abnormal_nervous_system0.83493899
122MP0000537_abnormal_urethra_morphology0.83370859
123MP0003646_muscle_fatigue0.82716525
124MP0004272_abnormal_basement_membrane0.82683023
125MP0002736_abnormal_nociception_after0.81401541
126MP0000579_abnormal_nail_morphology0.80825220
127MP0001968_abnormal_touch/_nociception0.79162645
128MP0003941_abnormal_skin_development0.78063274
129MP0001944_abnormal_pancreas_morphology0.77922663
130MP0001851_eye_inflammation0.77831029
131MP0002090_abnormal_vision0.77391832
132MP0002557_abnormal_social/conspecific_i0.75816678
133MP0000467_abnormal_esophagus_morphology0.75118548
134MP0003861_abnormal_nervous_system0.74209844
135MP0004133_heterotaxia0.74010681
136MP0004811_abnormal_neuron_physiology0.73071867
137MP0000631_abnormal_neuroendocrine_gland0.72103170
138MP0001501_abnormal_sleep_pattern0.70960625
139MP0001727_abnormal_embryo_implantation0.70848129
140MP0004036_abnormal_muscle_relaxation0.70593065
141MP0008438_abnormal_cutaneous_collagen0.69819129
142MP0004085_abnormal_heartbeat0.68453970
143MP0003137_abnormal_impulse_conducting0.68365833
144MP0005408_hypopigmentation0.65172850
145MP0002295_abnormal_pulmonary_circulatio0.65108932
146MP0000003_abnormal_adipose_tissue0.64927020
147MP0005645_abnormal_hypothalamus_physiol0.64785089

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.17374580
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.17374580
3Sensory axonal neuropathy (HP:0003390)5.45743538
4Neurofibrillary tangles (HP:0002185)5.42005175
5Parakeratosis (HP:0001036)4.75409202
6Abnormality of the corticospinal tract (HP:0002492)4.73101717
7Peripheral hypomyelination (HP:0007182)4.33804223
8Cerebral inclusion bodies (HP:0100314)3.90511939
9Febrile seizures (HP:0002373)3.73046005
10Onion bulb formation (HP:0003383)3.72205513
11Spastic gait (HP:0002064)3.66090557
12Akinesia (HP:0002304)3.65106325
13Pancreatic cysts (HP:0001737)3.49885468
14Supranuclear gaze palsy (HP:0000605)3.49856099
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45136929
16Alacrima (HP:0000522)3.43275052
17Hyperventilation (HP:0002883)3.42135265
18Progressive cerebellar ataxia (HP:0002073)3.37758337
19Cerebral hypomyelination (HP:0006808)3.29108598
20Intention tremor (HP:0002080)3.26293199
21Dysmetria (HP:0001310)3.19447809
22Pancreatic fibrosis (HP:0100732)3.17768775
23Fair hair (HP:0002286)3.11656202
24Abnormal auditory evoked potentials (HP:0006958)3.08956738
25Abnormality of the renal cortex (HP:0011035)3.07543762
26Termporal pattern (HP:0011008)3.07234112
27Insidious onset (HP:0003587)3.07234112
28Genetic anticipation (HP:0003743)3.06317910
29True hermaphroditism (HP:0010459)3.00175101
30Thickened helices (HP:0000391)2.93456058
31Anteriorly placed anus (HP:0001545)2.86688569
32Abnormality of the renal medulla (HP:0100957)2.84907977
33Decreased lacrimation (HP:0000633)2.80876066
34Atonic seizures (HP:0010819)2.80076526
35Nephronophthisis (HP:0000090)2.76700819
36Limb dystonia (HP:0002451)2.76301497
37Abnormality of midbrain morphology (HP:0002418)2.74768811
38Molar tooth sign on MRI (HP:0002419)2.74768811
39Tubular atrophy (HP:0000092)2.74330266
40Increased circulating renin level (HP:0000848)2.72557887
41Focal seizures (HP:0007359)2.70387201
42Congenital stationary night blindness (HP:0007642)2.68448752
43Medial flaring of the eyebrow (HP:0010747)2.68135597
44Premature skin wrinkling (HP:0100678)2.66486035
45Scanning speech (HP:0002168)2.63055845
46Retinal dysplasia (HP:0007973)2.60747781
47Myokymia (HP:0002411)2.60499576
48Hypoplastic labia majora (HP:0000059)2.60481641
49Hypoplastic pelvis (HP:0008839)2.58882880
50Hypothermia (HP:0002045)2.58157998
51Autoamputation (HP:0001218)2.56760843
52Slow saccadic eye movements (HP:0000514)2.53686063
53Ankle clonus (HP:0011448)2.46067636
54Drooling (HP:0002307)2.42203070
55Hypomagnesemia (HP:0002917)2.39339480
56Abnormality of the labia majora (HP:0012881)2.38256480
57Furrowed tongue (HP:0000221)2.36659757
58Dialeptic seizures (HP:0011146)2.35359820
59Gait imbalance (HP:0002141)2.35306308
60Generalized hypopigmentation of hair (HP:0011358)2.35068513
61Hemiparesis (HP:0001269)2.33932433
62Cystic liver disease (HP:0006706)2.33217128
63Inability to walk (HP:0002540)2.31734346
64Absent septum pellucidum (HP:0001331)2.31076733
65Congenital ichthyosiform erythroderma (HP:0007431)2.28935313
66Absence seizures (HP:0002121)2.28930231
67Epileptiform EEG discharges (HP:0011182)2.28869815
68Cupped ear (HP:0000378)2.26580532
69Split foot (HP:0001839)2.25691819
70Abnormal pancreas size (HP:0012094)2.24647561
71Segmental peripheral demyelination/remyelination (HP:0003481)2.23073387
72Genital tract atresia (HP:0001827)2.22102935
73Pheochromocytoma (HP:0002666)2.21763108
74Spastic paraparesis (HP:0002313)2.21429599
75EEG with generalized epileptiform discharges (HP:0011198)2.21124757
76Labial hypoplasia (HP:0000066)2.20846382
77Partial agenesis of the corpus callosum (HP:0001338)2.19866194
78Abnormality of the nasal septum (HP:0000419)2.19817463
79Absent speech (HP:0001344)2.19535726
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.18973027
81Metabolic alkalosis (HP:0200114)2.17773826
82Coronal craniosynostosis (HP:0004440)2.17190500
83Small epiphyses (HP:0010585)2.15933983
84Action tremor (HP:0002345)2.15216945
85Hypsarrhythmia (HP:0002521)2.15138401
86Excessive salivation (HP:0003781)2.14852428
87Relative macrocephaly (HP:0004482)2.14755784
88Chorioretinal atrophy (HP:0000533)2.14600703
89Adrenal hypoplasia (HP:0000835)2.13588902
90Clumsiness (HP:0002312)2.13010654
91Lower limb muscle weakness (HP:0007340)2.12669538
92Megalencephaly (HP:0001355)2.12457971
93Pendular nystagmus (HP:0012043)2.12117309
94Congenital primary aphakia (HP:0007707)2.11867505
95Leukodystrophy (HP:0002415)2.11581552
96Polydipsia (HP:0001959)2.11131315
97Abnormal drinking behavior (HP:0030082)2.11131315
98Protruding tongue (HP:0010808)2.09545071
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08529019
100Synostosis involving the elbow (HP:0003938)2.06427306
101Humeroradial synostosis (HP:0003041)2.06427306
102Large for gestational age (HP:0001520)2.04200816
103Cerebral hemorrhage (HP:0001342)2.04090747
104Agitation (HP:0000713)2.04066922
105Aplasia involving bones of the upper limbs (HP:0009823)2.03004487
106Aplasia of the phalanges of the hand (HP:0009802)2.03004487
107Aplasia involving bones of the extremities (HP:0009825)2.03004487
108Progressive inability to walk (HP:0002505)2.00698364
109Abnormality of the septum pellucidum (HP:0007375)2.00364480
110Abnormality of macular pigmentation (HP:0008002)1.99472567
111Focal motor seizures (HP:0011153)1.99281343
112Bowel incontinence (HP:0002607)1.99275832
113Chronic hepatic failure (HP:0100626)1.97936526
114Epileptic encephalopathy (HP:0200134)1.97750321
115Decreased motor nerve conduction velocity (HP:0003431)1.97686114
116Esophageal atresia (HP:0002032)1.96566508
117Abnormality of secondary sexual hair (HP:0009888)1.95989655
118Abnormality of the axillary hair (HP:0100134)1.95989655
119Absent eyebrow (HP:0002223)1.95920072
120Hypokalemic alkalosis (HP:0001949)1.95121602
121Stridor (HP:0010307)1.94832972
122Muscle fiber splitting (HP:0003555)1.94424004
123Nephrogenic diabetes insipidus (HP:0009806)1.93182293
124Ketoacidosis (HP:0001993)1.93179853
125Abolished electroretinogram (ERG) (HP:0000550)1.92663344
126Generalized myoclonic seizures (HP:0002123)1.92430940
127Hypoplasia of the iris (HP:0007676)1.90765109
128Renal cortical cysts (HP:0000803)1.90666566
129Attenuation of retinal blood vessels (HP:0007843)1.90625282
130Abnormality of chloride homeostasis (HP:0011422)1.90488758
131Confusion (HP:0001289)1.89649144
132Morphological abnormality of the inner ear (HP:0011390)1.89494929
133Polyuria (HP:0000103)1.89488374
134Tubulointerstitial fibrosis (HP:0005576)1.89233707
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89120852
136Barrel-shaped chest (HP:0001552)1.88856028
137Abnormal biliary tract morphology (HP:0012440)1.88702705
138Foot dorsiflexor weakness (HP:0009027)1.88262542
139Steppage gait (HP:0003376)1.88176246
140Neuroendocrine neoplasm (HP:0100634)1.88135788
141CNS hypomyelination (HP:0003429)1.87790447
142Decreased circulating renin level (HP:0003351)1.87584411
143Widely spaced teeth (HP:0000687)1.86554563
144Infantile muscular hypotonia (HP:0008947)1.86512873
145Mixed hearing impairment (HP:0000410)1.86468187
146Abnormal large intestine physiology (HP:0012700)1.85790320
147Epidermoid cyst (HP:0200040)1.84296437
148Type II lissencephaly (HP:0007260)1.84094342
149Septo-optic dysplasia (HP:0100842)1.83354303
150Gaze-evoked nystagmus (HP:0000640)1.82342398
151Diminished movement (HP:0002374)1.82225178
152Poor speech (HP:0002465)1.81985198
153Hyperinsulinemic hypoglycemia (HP:0000825)1.81899400
154Hypoplastic female external genitalia (HP:0012815)1.81494191
155White forelock (HP:0002211)1.80727223
156Lissencephaly (HP:0001339)1.80526666
157Vaginal atresia (HP:0000148)1.80470762
158Exotropia (HP:0000577)1.79629426
159Abnormality of the parathyroid morphology (HP:0011766)1.78999923
160Chin dimple (HP:0010751)1.78403457
161Prominent supraorbital ridges (HP:0000336)1.78180461
162Poor coordination (HP:0002370)1.76834578
163Abnormality of renin-angiotensin system (HP:0000847)1.75887145
164Tubulointerstitial abnormality (HP:0001969)1.75883473
165Abnormality of glycolysis (HP:0004366)1.75742919
166Increased serum pyruvate (HP:0003542)1.75742919
167Broad-based gait (HP:0002136)1.75660215
168Hammertoe (HP:0001765)1.75625043
169Potter facies (HP:0002009)1.75546464
170Facial shape deformation (HP:0011334)1.75546464
171Congenital hepatic fibrosis (HP:0002612)1.75187907
172Decreased central vision (HP:0007663)1.75032774
173Gowers sign (HP:0003391)1.75031566
174Clonus (HP:0002169)1.73861494
175Abnormality of the foot musculature (HP:0001436)1.73746608
176Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.73202132
177Epiphyseal dysplasia (HP:0002656)1.73081905
178Hyporeflexia of lower limbs (HP:0002600)1.72966548
179Abnormality of renal excretion (HP:0011036)1.71167510
180Congenital sensorineural hearing impairment (HP:0008527)1.71128167
181Polyphagia (HP:0002591)1.70565922
182Keratoconus (HP:0000563)1.68596814
183Increased corneal curvature (HP:0100692)1.68596814
184Congenital, generalized hypertrichosis (HP:0004540)1.65567975
185Abnormal urine output (HP:0012590)1.64218927
186Dyskinesia (HP:0100660)1.63523510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.13810257
2FRK5.75059404
3OXSR14.72413344
4BCR3.11888224
5TNIK2.95945059
6WNK42.70122762
7CDK192.58120425
8EPHB12.58021197
9LMTK22.44777468
10ACVR1B2.41826343
11MET2.37415259
12PKN12.30686648
13WNK12.21563521
14ICK2.21034125
15FGFR22.17210434
16NEK62.10787874
17PRPF4B2.04350925
18LIMK11.95804665
19UHMK11.87435484
20CSNK1A1L1.85524631
21MAP4K21.83525231
22ADRBK21.81941679
23DAPK21.81666382
24CSNK1G31.79901066
25PBK1.76423338
26PNCK1.68451903
27AKT31.67232030
28PINK11.64713389
29EPHA41.62566202
30GRK11.60815674
31NTRK11.54971601
32PAK61.54963261
33STK38L1.49847541
34ROCK21.44140090
35CSNK1G21.43875794
36FGR1.42972028
37CSNK1G11.39689890
38MARK11.38783559
39CAMK2B1.31069211
40SGK21.28651413
41FER1.27127757
42CLK11.25345309
43TYRO31.24382212
44TIE11.16816929
45PAK31.15759480
46CAMK2D1.15530941
47TGFBR11.13593075
48CAMKK21.10660868
49PRKCG1.10378562
50CASK1.09901811
51MAPK151.07462086
52MKNK21.02083439
53PLK21.01613060
54IRAK21.01475978
55MAP2K70.96913305
56STK240.95779148
57SGK4940.95434769
58SGK2230.95434769
59CDK50.92132232
60MARK20.91998880
61MST40.91031284
62STK380.90905805
63WNK30.89299913
64CDK140.85185216
65ERBB40.83296028
66LATS10.82140230
67ZAK0.80202368
68KSR20.79237702
69CAMK2A0.75535204
70FGFR10.74892620
71ERBB30.74827863
72PTK2B0.74079420
73ADRBK10.73913998
74CAMK2G0.73054583
75PRKCQ0.72225488
76MAP2K60.71800339
77TRIM280.71283643
78MAP3K20.70731634
79CDK150.69897021
80DYRK20.68875575
81NLK0.66647840
82MAP3K90.66485399
83MAP3K130.66300876
84CDK180.65616687
85MAPK130.65615175
86STK30.65149542
87TRPM70.65114411
88MAPKAPK50.64099651
89PRKG20.62502056
90CDK11A0.62279951
91TAOK30.61872569
92CAMK10.61756662
93PRKCE0.61288200
94FYN0.60889339
95PDPK10.60798784
96PHKG10.60448009
97PHKG20.60448009
98STK110.60435552
99SGK30.59734208
100BMPR1B0.59302727
101IRAK10.59066947
102MAP3K120.56017915
103MAP3K70.55349314
104PRKAA10.55297351
105PRKAA20.54954434
106CSNK1D0.54680620
107NTRK20.53658091
108PRKD10.52965975
109ARAF0.52430078
110NTRK30.51157388
111CAMK1G0.50542236
112PRKCH0.49165324
113PDGFRB0.48858548
114PRKACA0.45925643
115INSRR0.45698149
116PRKG10.44865751
117ERBB20.44863687
118ROCK10.44689918
119FGFR30.44149619
120SIK20.43822907
121MAP2K40.42374416
122PRKCZ0.41451726
123DMPK0.41049807
124MELK0.40271349
125DYRK1A0.40265888
126CSNK1A10.39981698
127CAMK40.37302125
128CAMKK10.35868756
129MAPK100.35786351
130KSR10.35032319
131PIK3CA0.34914023
132GRK50.34899897
133HIPK20.34216524
134BRD40.33440610
135INSR0.33041337
136MAPK70.32992309
137PTK20.32429182
138MAP3K40.31876169
139PRKD30.31055687
140GSK3A0.30564915
141ITK0.30410010
142SGK10.29758230
143PRKACB0.29693433
144OBSCN0.28110978
145CDK30.27848086
146NUAK10.27715465
147MINK10.26646071
148PDK10.26636028

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.40334119
2Steroid biosynthesis_Homo sapiens_hsa001003.60212018
3Fatty acid elongation_Homo sapiens_hsa000622.99976960
4Ether lipid metabolism_Homo sapiens_hsa005652.84305970
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71915025
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.71022758
7Axon guidance_Homo sapiens_hsa043602.45035647
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41363147
9Circadian rhythm_Homo sapiens_hsa047101.93758366
10Sphingolipid metabolism_Homo sapiens_hsa006001.93304490
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.82729007
12Glutamatergic synapse_Homo sapiens_hsa047241.69486106
13GABAergic synapse_Homo sapiens_hsa047271.66991333
14ABC transporters_Homo sapiens_hsa020101.66882774
15Serotonergic synapse_Homo sapiens_hsa047261.66262476
16Sulfur metabolism_Homo sapiens_hsa009201.66252714
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63318212
18Protein export_Homo sapiens_hsa030601.62590289
19Nitrogen metabolism_Homo sapiens_hsa009101.60307616
20Renal cell carcinoma_Homo sapiens_hsa052111.53633009
21Tryptophan metabolism_Homo sapiens_hsa003801.46883539
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43577879
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43361220
24Morphine addiction_Homo sapiens_hsa050321.41095856
25Long-term depression_Homo sapiens_hsa047301.36892317
26Vibrio cholerae infection_Homo sapiens_hsa051101.36388549
27Phototransduction_Homo sapiens_hsa047441.32776272
28Tight junction_Homo sapiens_hsa045301.31805943
29Collecting duct acid secretion_Homo sapiens_hsa049661.28470884
30Nicotine addiction_Homo sapiens_hsa050331.28261527
31Oxidative phosphorylation_Homo sapiens_hsa001901.27207556
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26077756
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25614329
34Selenocompound metabolism_Homo sapiens_hsa004501.24784413
35Retinol metabolism_Homo sapiens_hsa008301.21911830
36Linoleic acid metabolism_Homo sapiens_hsa005911.21248218
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.19532154
38Bile secretion_Homo sapiens_hsa049761.18396515
39Circadian entrainment_Homo sapiens_hsa047131.17716135
40Synaptic vesicle cycle_Homo sapiens_hsa047211.17085467
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.14218563
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14201015
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13282778
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13122630
45Dorso-ventral axis formation_Homo sapiens_hsa043201.12537149
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09977182
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.07653273
48beta-Alanine metabolism_Homo sapiens_hsa004101.07069720
49Cholinergic synapse_Homo sapiens_hsa047251.04692037
50ErbB signaling pathway_Homo sapiens_hsa040121.04121794
51Cocaine addiction_Homo sapiens_hsa050301.03488299
52Endocytosis_Homo sapiens_hsa041441.02617997
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.00073007
54Dopaminergic synapse_Homo sapiens_hsa047280.99573363
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97141540
56Butanoate metabolism_Homo sapiens_hsa006500.97094156
57Ras signaling pathway_Homo sapiens_hsa040140.97026845
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96601035
59Salivary secretion_Homo sapiens_hsa049700.96476122
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96107131
61Chemical carcinogenesis_Homo sapiens_hsa052040.95230952
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.93821166
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93230010
64Vitamin B6 metabolism_Homo sapiens_hsa007500.91924933
65Alzheimers disease_Homo sapiens_hsa050100.91848881
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91562853
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90825487
68Rheumatoid arthritis_Homo sapiens_hsa053230.89864665
69Caffeine metabolism_Homo sapiens_hsa002320.86700664
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85338006
71ECM-receptor interaction_Homo sapiens_hsa045120.85192269
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84493639
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84400802
74Glycerolipid metabolism_Homo sapiens_hsa005610.84187958
75Propanoate metabolism_Homo sapiens_hsa006400.83886440
76Cardiac muscle contraction_Homo sapiens_hsa042600.83797677
77Pancreatic secretion_Homo sapiens_hsa049720.82438329
78Peroxisome_Homo sapiens_hsa041460.81702871
79Ovarian steroidogenesis_Homo sapiens_hsa049130.81325672
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79778211
81Lysosome_Homo sapiens_hsa041420.79618821
82Long-term potentiation_Homo sapiens_hsa047200.78788629
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78738673
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78682329
85Autoimmune thyroid disease_Homo sapiens_hsa053200.78468060
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78152787
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78016264
88Gastric acid secretion_Homo sapiens_hsa049710.77379571
89Amphetamine addiction_Homo sapiens_hsa050310.76604155
90Choline metabolism in cancer_Homo sapiens_hsa052310.74662892
91Fat digestion and absorption_Homo sapiens_hsa049750.74537727
92Insulin secretion_Homo sapiens_hsa049110.72295683
93Hedgehog signaling pathway_Homo sapiens_hsa043400.72031273
94Arginine and proline metabolism_Homo sapiens_hsa003300.69938526
95cAMP signaling pathway_Homo sapiens_hsa040240.68440313
96Fatty acid degradation_Homo sapiens_hsa000710.68221775
97Oxytocin signaling pathway_Homo sapiens_hsa049210.68014144
98Fatty acid biosynthesis_Homo sapiens_hsa000610.67717181
99Taste transduction_Homo sapiens_hsa047420.67483715
100Gap junction_Homo sapiens_hsa045400.67285190
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65885507
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64748137
103Renin secretion_Homo sapiens_hsa049240.64471938
104Complement and coagulation cascades_Homo sapiens_hsa046100.64093966
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62798264
106Mineral absorption_Homo sapiens_hsa049780.62684799
107Starch and sucrose metabolism_Homo sapiens_hsa005000.62212729
108Histidine metabolism_Homo sapiens_hsa003400.61867294
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.61827929
110Parkinsons disease_Homo sapiens_hsa050120.60871723
111Vitamin digestion and absorption_Homo sapiens_hsa049770.60314839
112Thyroid hormone synthesis_Homo sapiens_hsa049180.60163702
113MAPK signaling pathway_Homo sapiens_hsa040100.59826101
114Arachidonic acid metabolism_Homo sapiens_hsa005900.59296059
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58513549
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57740063
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56964430
118Phagosome_Homo sapiens_hsa041450.56454193
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55805993
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55548809
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53670787
122Dilated cardiomyopathy_Homo sapiens_hsa054140.53644543
123Olfactory transduction_Homo sapiens_hsa047400.52707261
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52262529
125Wnt signaling pathway_Homo sapiens_hsa043100.51364450
126Type II diabetes mellitus_Homo sapiens_hsa049300.48384427
127Glucagon signaling pathway_Homo sapiens_hsa049220.47863259
128Arginine biosynthesis_Homo sapiens_hsa002200.47827505
129Malaria_Homo sapiens_hsa051440.47548974
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46843639
131Calcium signaling pathway_Homo sapiens_hsa040200.46597473
132Inositol phosphate metabolism_Homo sapiens_hsa005620.46182400
133GnRH signaling pathway_Homo sapiens_hsa049120.44802249
134Melanogenesis_Homo sapiens_hsa049160.44581721
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42336326
136Protein digestion and absorption_Homo sapiens_hsa049740.42125719
137Regulation of autophagy_Homo sapiens_hsa041400.40142390
138Hippo signaling pathway_Homo sapiens_hsa043900.39116175
139Focal adhesion_Homo sapiens_hsa045100.39025663
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38798575

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