PLEKHA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.87290012
2B cell receptor signaling pathway (GO:0050853)5.87420794
3antigen processing and presentation of endogenous antigen (GO:0019883)5.49159294
4regulation of gamma-delta T cell differentiation (GO:0045586)5.10999668
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07395625
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.07395625
7positive regulation of B cell differentiation (GO:0045579)4.80222040
8regulation of gamma-delta T cell activation (GO:0046643)4.79724554
9regulation of B cell receptor signaling pathway (GO:0050855)4.66262479
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35906717
11neutrophil activation involved in immune response (GO:0002283)4.30606031
12regulation of B cell differentiation (GO:0045577)4.22562181
13positive thymic T cell selection (GO:0045059)4.02502040
14neutrophil activation (GO:0042119)3.95426805
15detection of other organism (GO:0098543)3.90527325
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80301383
17cellular response to zinc ion (GO:0071294)3.79344237
18leukocyte aggregation (GO:0070486)3.74164099
19detection of bacterium (GO:0016045)3.72449285
20hepatocyte apoptotic process (GO:0097284)3.72272355
21negative regulation of interleukin-12 production (GO:0032695)3.67901674
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64582058
23granulocyte activation (GO:0036230)3.62332235
24negative thymic T cell selection (GO:0045060)3.53173063
25regulation of alpha-beta T cell proliferation (GO:0046640)3.50034167
26response to peptidoglycan (GO:0032494)3.49485406
27negative T cell selection (GO:0043383)3.48144948
28tolerance induction (GO:0002507)3.47676631
29NIK/NF-kappaB signaling (GO:0038061)3.47203850
30production of molecular mediator involved in inflammatory response (GO:0002532)3.43301997
31negative regulation of phagocytosis (GO:0050765)3.40368502
32regulation of antigen processing and presentation (GO:0002577)3.36788743
33detection of external biotic stimulus (GO:0098581)3.36419121
34T cell selection (GO:0045058)3.32395433
35antigen receptor-mediated signaling pathway (GO:0050851)3.32310582
36myeloid dendritic cell activation (GO:0001773)3.30244623
37T cell homeostasis (GO:0043029)3.30236888
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29219587
39detection of molecule of bacterial origin (GO:0032490)3.28071376
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.27308667
41T cell migration (GO:0072678)3.26096181
42negative regulation of T cell mediated immunity (GO:0002710)3.25569685
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25209418
44negative regulation of B cell proliferation (GO:0030889)3.24803397
45immunoglobulin mediated immune response (GO:0016064)3.24270737
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.23381913
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23066706
48natural killer cell differentiation (GO:0001779)3.22491525
49mature B cell differentiation (GO:0002335)3.20999165
50positive regulation of alpha-beta T cell proliferation (GO:0046641)3.20093980
51lymphocyte homeostasis (GO:0002260)3.15041967
52negative regulation of T-helper cell differentiation (GO:0045623)3.14145897
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14145897
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13521660
55response to interleukin-15 (GO:0070672)3.13344383
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12908053
57macrophage activation involved in immune response (GO:0002281)3.12475455
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11083016
59response to type I interferon (GO:0034340)3.10914453
60negative regulation of erythrocyte differentiation (GO:0045647)3.10687613
61germinal center formation (GO:0002467)3.09466655
62B cell proliferation (GO:0042100)3.09162289
63interferon-gamma-mediated signaling pathway (GO:0060333)3.07963407
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07748428
65negative regulation of cell killing (GO:0031342)3.07748428
66myeloid dendritic cell differentiation (GO:0043011)3.07518533
67cellular extravasation (GO:0045123)3.06893638
68modulation by symbiont of host immune response (GO:0052553)3.06415661
69positive regulation by symbiont of host defense response (GO:0052509)3.06415661
70modulation by symbiont of host defense response (GO:0052031)3.06415661
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06415661
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06415661
73positive regulation by organism of defense response of other organism involved in symbiotic interact3.06415661
74positive T cell selection (GO:0043368)3.05750360
75positive regulation of interleukin-2 production (GO:0032743)3.05718572
76thymic T cell selection (GO:0045061)3.05119684
77cellular response to type I interferon (GO:0071357)3.04473679
78type I interferon signaling pathway (GO:0060337)3.04473679
79regulation of mast cell degranulation (GO:0043304)3.04121427
80negative regulation of leukocyte mediated immunity (GO:0002704)3.03138162
81regulation of B cell proliferation (GO:0030888)2.99509713
82cellular response to interleukin-15 (GO:0071350)2.99348447
83respiratory burst (GO:0045730)2.97870337
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97786406
85B cell homeostasis (GO:0001782)2.97341744
86macrophage activation (GO:0042116)2.97116391
87response to host immune response (GO:0052572)2.96718107
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96718107
89defense response to protozoan (GO:0042832)2.96366471
90positive regulation of interferon-alpha production (GO:0032727)2.94394658
91response to muramyl dipeptide (GO:0032495)2.93254220
92detection of biotic stimulus (GO:0009595)2.92432437
93microglial cell activation (GO:0001774)2.92085478
94regulation of superoxide anion generation (GO:0032928)2.90831057
95regulation of interferon-beta biosynthetic process (GO:0045357)2.89459813
96immune response-activating cell surface receptor signaling pathway (GO:0002429)2.88965957
97antigen processing and presentation via MHC class Ib (GO:0002475)2.88869939
98positive regulation of mast cell activation (GO:0033005)2.88316730
99positive regulation of granulocyte differentiation (GO:0030854)2.86903564
100positive regulation of antigen processing and presentation (GO:0002579)2.86574741
101leukocyte homeostasis (GO:0001776)2.85203280
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.84782395
103response to host (GO:0075136)2.84782395
104response to host defenses (GO:0052200)2.84782395
105leukocyte cell-cell adhesion (GO:0007159)2.84383603
106positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83950692
107regulation of mast cell activation involved in immune response (GO:0033006)2.83180793
108T cell costimulation (GO:0031295)2.82986980
109regulation of interferon-alpha production (GO:0032647)2.82177485
110serine transport (GO:0032329)2.81444539
111mast cell activation (GO:0045576)2.81065144
112response to protozoan (GO:0001562)2.80062006
113regulation of tolerance induction (GO:0002643)2.80000975
114myeloid cell activation involved in immune response (GO:0002275)2.79782815
115regulation of T-helper 2 cell differentiation (GO:0045628)2.78550944
116positive regulation of alpha-beta T cell differentiation (GO:0046638)2.77325603
117lymphocyte costimulation (GO:0031294)2.77063497
118positive regulation of B cell activation (GO:0050871)2.76569762
119mucosal-associated lymphoid tissue development (GO:0048537)2.76564869
120Peyers patch development (GO:0048541)2.76564869
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76372227
122mature B cell differentiation involved in immune response (GO:0002313)2.75760801
123regulation of leukocyte degranulation (GO:0043300)2.75281945
124CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73727054
125regulation of mast cell activation (GO:0033003)2.73665307
126natural killer cell activation (GO:0030101)2.72668969
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71529771
128regulation of T cell tolerance induction (GO:0002664)2.70791260
129V(D)J recombination (GO:0033151)2.67972517
130negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.67721500
131T cell proliferation (GO:0042098)2.67664820
132positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.66280124
133positive regulation of B cell proliferation (GO:0030890)2.65678915
134positive regulation of cytokine biosynthetic process (GO:0042108)2.65307924
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.64747261
136B cell mediated immunity (GO:0019724)2.63929676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.89617868
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.52680066
3E2F7_22180533_ChIP-Seq_HELA_Human5.07940410
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.40102419
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.19121137
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09075526
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.52971446
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42404944
9MYC_22102868_ChIP-Seq_BL_Human3.42045975
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.27883484
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98904304
12* VDR_21846776_ChIP-Seq_THP-1_Human2.90711157
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.89512425
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84649857
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.80923082
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74771330
17RUNX_20019798_ChIP-Seq_JUKART_Human2.74366319
18MYB_26560356_Chip-Seq_TH2_Human2.67753747
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.66341013
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59378448
21SCL_19346495_ChIP-Seq_HPC-7_Human2.57703162
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57159412
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54445483
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49644865
25MAF_26560356_Chip-Seq_TH1_Human2.43530832
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35090615
27MYB_26560356_Chip-Seq_TH1_Human2.30948404
28* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24127628
29SPI1_23547873_ChIP-Seq_NB4_Human2.22970471
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21399360
31UTX_26944678_Chip-Seq_JUKART_Human2.13821246
32VDR_24763502_ChIP-Seq_THP-1_Human2.12814865
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03946662
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00177954
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.93686026
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87389868
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86984172
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85169616
39TCF7_22412390_ChIP-Seq_EML_Mouse1.82277644
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78570347
41* SPI1_23127762_ChIP-Seq_K562_Human1.75050378
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71644626
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62435724
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61919592
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54542623
46GATA1_22025678_ChIP-Seq_K562_Human1.50771440
47GATA3_27048872_Chip-Seq_THYMUS_Human1.50733925
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47459223
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46394688
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46110117
51PU_27001747_Chip-Seq_BMDM_Mouse1.45338791
52KDM2B_26808549_Chip-Seq_DND41_Human1.40811361
53MAF_26560356_Chip-Seq_TH2_Human1.40533460
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40398709
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35964121
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30263981
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29224505
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28385033
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23204640
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22432296
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.21929515
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18817078
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15484464
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13814024
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12336795
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12173064
67* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12038437
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10922656
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10426546
70VDR_24787735_ChIP-Seq_THP-1_Human1.10091667
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09682576
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08199334
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07697811
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07694359
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03535895
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02981689
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02465713
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.01612559
79GATA3_26560356_Chip-Seq_TH2_Human1.00752627
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00590039
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00076102
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98889834
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97594958
84CIITA_25753668_ChIP-Seq_RAJI_Human0.96708228
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90352607
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.89424822
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89155708
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88554327
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87691847
90* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86945153
91* NCOR1_26117541_ChIP-Seq_K562_Human0.86081301
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85956274
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85900443
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.85506386
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.82875096
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80060444
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78864039
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78591675
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.77932944
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76588782
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76173595
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75029470
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74638017
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74354032
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73296176
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73229556
107LXR_22292898_ChIP-Seq_THP-1_Human0.72277759
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72080757
109E2F1_21310950_ChIP-Seq_MCF-7_Human0.70322739
110* SMRT_27268052_Chip-Seq_Bcells_Human0.70287054
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.70021682
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.68757886
113GATA1_19941826_ChIP-Seq_K562_Human0.68155453
114GATA2_19941826_ChIP-Seq_K562_Human0.67829893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40649237
2MP0000685_abnormal_immune_system3.96473242
3MP0005387_immune_system_phenotype3.64465835
4MP0001790_abnormal_immune_system3.64465835
5MP0001800_abnormal_humoral_immune3.64257067
6MP0005671_abnormal_response_to3.33827416
7MP0002452_abnormal_antigen_presenting3.08096270
8MP0005000_abnormal_immune_tolerance2.95488730
9MP0003303_peritoneal_inflammation2.81636528
10MP0002723_abnormal_immune_serum2.78295557
11MP0002420_abnormal_adaptive_immunity2.71981277
12MP0003436_decreased_susceptibility_to2.71899235
13MP0001819_abnormal_immune_cell2.69316093
14MP0009785_altered_susceptibility_to2.68508429
15MP0002166_altered_tumor_susceptibility2.60823546
16MP0002398_abnormal_bone_marrow2.54880380
17MP0005025_abnormal_response_to2.40674857
18MP0002148_abnormal_hypersensitivity_rea2.37908808
19MP0000716_abnormal_immune_system2.34164858
20MP0003763_abnormal_thymus_physiology2.33590363
21MP0003300_gastrointestinal_ulcer2.23285467
22MP0002419_abnormal_innate_immunity2.21532373
23MP0002396_abnormal_hematopoietic_system2.19094076
24MP0000689_abnormal_spleen_morphology2.15563242
25MP0002006_tumorigenesis2.14150083
26MP0004510_myositis2.09895967
27MP0002722_abnormal_immune_system2.03740362
28MP0002405_respiratory_system_inflammati1.93486772
29MP0002429_abnormal_blood_cell1.93258381
30MP0010155_abnormal_intestine_physiology1.90631488
31MP0004947_skin_inflammation1.83749949
32MP0006082_CNS_inflammation1.83712604
33MP0004808_abnormal_hematopoietic_stem1.77843910
34MP0000703_abnormal_thymus_morphology1.76170711
35MP0005464_abnormal_platelet_physiology1.65578436
36MP0001845_abnormal_inflammatory_respons1.62129979
37MP0001873_stomach_inflammation1.59321839
38MP0006054_spinal_hemorrhage1.59298950
39MP0004381_abnormal_hair_follicle1.59056245
40MP0002933_joint_inflammation1.57194470
41MP0009333_abnormal_splenocyte_physiolog1.56716018
42MP0009278_abnormal_bone_marrow1.43216769
43MP0000465_gastrointestinal_hemorrhage1.42612332
44MP0005310_abnormal_salivary_gland1.42471492
45MP0001853_heart_inflammation1.40802467
46MP0000569_abnormal_digit_pigmentation1.39054271
47MP0003866_abnormal_defecation1.35707455
48MP0005451_abnormal_body_composition1.29576708
49MP0003724_increased_susceptibility_to1.27781701
50MP0001533_abnormal_skeleton_physiology1.27184514
51MP0003448_altered_tumor_morphology1.26847201
52MP0000490_abnormal_crypts_of1.20999344
53MP0001545_abnormal_hematopoietic_system1.20537469
54MP0005397_hematopoietic_system_phenotyp1.20537469
55MP0000858_altered_metastatic_potential1.17142652
56MP0003566_abnormal_cell_adhesion1.15730047
57MP0004883_abnormal_blood_vessel1.11363734
58MP0008260_abnormal_autophagy1.10712988
59MP0010307_abnormal_tumor_latency1.10237066
60MP0001879_abnormal_lymphatic_vessel1.09756131
61MP0002019_abnormal_tumor_incidence1.07530063
62MP0010352_gastrointestinal_tract_polyps1.07268174
63MP0008469_abnormal_protein_level1.00713426
64MP0000604_amyloidosis1.00541096
65MP0010094_abnormal_chromosome_stability0.99924092
66MP0005166_decreased_susceptibility_to0.98582594
67MP0002009_preneoplasia0.98300054
68MP0001851_eye_inflammation0.98151793
69MP0003183_abnormal_peptide_metabolism0.96853184
70MP0003091_abnormal_cell_migration0.96008391
71MP0005174_abnormal_tail_pigmentation0.95597254
72MP0003453_abnormal_keratinocyte_physiol0.94271994
73MP0003690_abnormal_glial_cell0.94267499
74MP0003075_altered_response_to0.93557909
75MP0002998_abnormal_bone_remodeling0.93425016
76MP0005076_abnormal_cell_differentiation0.91586937
77MP0005164_abnormal_response_to0.91000844
78MP0003077_abnormal_cell_cycle0.90174251
79MP0005058_abnormal_lysosome_morphology0.89039565
80MP0005075_abnormal_melanosome_morpholog0.88591770
81MP0009840_abnormal_foam_cell0.88125340
82MP0003656_abnormal_erythrocyte_physiolo0.88095739
83MP0008057_abnormal_DNA_replication0.86835647
84MP0003828_pulmonary_edema0.84520779
85MP0004130_abnormal_muscle_cell0.83249808
86MP0002877_abnormal_melanocyte_morpholog0.81133442
87MP0003172_abnormal_lysosome_physiology0.81024282
88MP0000343_altered_response_to0.74404899
89MP0005023_abnormal_wound_healing0.74119134
90MP0003045_fibrosis0.74032771
91MP0000371_diluted_coat_color0.70739914
92MP0002095_abnormal_skin_pigmentation0.69823272
93MP0000249_abnormal_blood_vessel0.69635227
94MP0002136_abnormal_kidney_physiology0.68567968
95MP0002332_abnormal_exercise_endurance0.67565124
96MP0002132_abnormal_respiratory_system0.66423888
97MP0001958_emphysema0.65939664
98MP0000733_abnormal_muscle_development0.65854134
99MP0002254_reproductive_system_inflammat0.64579352
100MP0009764_decreased_sensitivity_to0.63324077
101MP0002138_abnormal_hepatobiliary_system0.62372159
102MP0008004_abnormal_stomach_pH0.61984790
103MP0001663_abnormal_digestive_system0.61569517
104MP0003279_aneurysm0.61182889
105MP0009115_abnormal_fat_cell0.60358045
106MP0010234_abnormal_vibrissa_follicle0.58960864
107MP0001986_abnormal_taste_sensitivity0.58186355
108MP0004484_altered_response_of0.57966625
109MP0009763_increased_sensitivity_to0.56759238
110MP0001348_abnormal_lacrimal_gland0.56037084
111MP0000313_abnormal_cell_death0.55148086
112MP0000015_abnormal_ear_pigmentation0.54261787
113MP0008007_abnormal_cellular_replicative0.53153102
114MP0001915_intracranial_hemorrhage0.52887761
115MP0000350_abnormal_cell_proliferation0.52614342
116MP0000767_abnormal_smooth_muscle0.52479963
117MP0003191_abnormal_cellular_cholesterol0.52287961
118MP0005390_skeleton_phenotype0.51852134
119MP0003795_abnormal_bone_structure0.50890346
120MP0005621_abnormal_cell_physiology0.50717893

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.33161714
2Cellulitis (HP:0100658)5.40798045
3Recurrent viral infections (HP:0004429)4.99207328
4Recurrent bronchitis (HP:0002837)4.94746838
5B lymphocytopenia (HP:0010976)4.59139506
6Abnormality of B cell number (HP:0010975)4.59139506
7Chronic otitis media (HP:0000389)4.53245418
8Papilloma (HP:0012740)4.52018769
9Verrucae (HP:0200043)4.52018769
10Recurrent abscess formation (HP:0002722)4.40434615
11Panhypogammaglobulinemia (HP:0003139)4.37382849
12Recurrent fungal infections (HP:0002841)4.34794475
13Thyroiditis (HP:0100646)4.31797482
14Meningitis (HP:0001287)4.20613914
15Gastrointestinal stroma tumor (HP:0100723)4.13756380
16Chronic sinusitis (HP:0011109)4.01310882
17Recurrent bacterial skin infections (HP:0005406)3.92812780
18Eczematoid dermatitis (HP:0000976)3.90751590
19Inflammation of the large intestine (HP:0002037)3.83642219
20Colitis (HP:0002583)3.80793956
21T lymphocytopenia (HP:0005403)3.73494534
22IgM deficiency (HP:0002850)3.72178837
23Recurrent sinusitis (HP:0011108)3.71952571
24Gastrointestinal inflammation (HP:0004386)3.70970354
25Abnormality of T cell number (HP:0011839)3.70749858
26Osteomyelitis (HP:0002754)3.63375342
27Lymphopenia (HP:0001888)3.48081175
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.46967328
29Chronic mucocutaneous candidiasis (HP:0002728)3.41347904
30Recurrent cutaneous fungal infections (HP:0011370)3.41347904
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.39476567
32Severe combined immunodeficiency (HP:0004430)3.36641863
33Recurrent pneumonia (HP:0006532)3.34772278
34Vasculitis (HP:0002633)3.28462365
35Combined immunodeficiency (HP:0005387)3.17837836
36Eosinophilia (HP:0001880)3.15625091
37Gastrointestinal infarctions (HP:0005244)3.15113218
38Sepsis (HP:0100806)3.12626472
39Recurrent skin infections (HP:0001581)3.12514258
40Small epiphyses (HP:0010585)3.12155135
41Recurrent lower respiratory tract infections (HP:0002783)3.09528218
42IgG deficiency (HP:0004315)3.06530704
43Abnormality of T cells (HP:0002843)3.05733994
44Mediastinal lymphadenopathy (HP:0100721)3.04438771
45Autoimmune thrombocytopenia (HP:0001973)2.90721149
46Emphysema (HP:0002097)2.90156067
47Chronic obstructive pulmonary disease (HP:0006510)2.87306365
48Obstructive lung disease (HP:0006536)2.87306365
49Elevated erythrocyte sedimentation rate (HP:0003565)2.79082812
50Interstitial pulmonary disease (HP:0006530)2.76385483
51Keratoconjunctivitis sicca (HP:0001097)2.76063182
52Granulocytopenia (HP:0001913)2.73879547
53Bronchitis (HP:0012387)2.73625899
54Myositis (HP:0100614)2.73356295
55Pustule (HP:0200039)2.72357830
56Hemoptysis (HP:0002105)2.72239548
57Abnormality of eosinophils (HP:0001879)2.70846730
58Nasal polyposis (HP:0100582)2.69862126
59Abnormality of glycolipid metabolism (HP:0010969)2.64817535
60Abnormality of liposaccharide metabolism (HP:0010968)2.64817535
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.64817535
62IgA deficiency (HP:0002720)2.63030602
63Abnormality of T cell physiology (HP:0011840)2.56410753
64Leukocytosis (HP:0001974)2.54060133
65Keratoconjunctivitis (HP:0001096)2.50853590
66Spontaneous hematomas (HP:0007420)2.49098992
67Lymphoma (HP:0002665)2.49025208
68Abnormality of macrophages (HP:0004311)2.45940339
69Thrombocytosis (HP:0001894)2.45054929
70Abnormality of the fingertips (HP:0001211)2.41939093
71Abnormality of the nasal mucosa (HP:0000433)2.40285067
72Restrictive lung disease (HP:0002091)2.40142089
73Skin ulcer (HP:0200042)2.39302471
74Recurrent otitis media (HP:0000403)2.37082562
75Increased IgE level (HP:0003212)2.35995510
76Epistaxis (HP:0000421)2.33902240
77Vertebral arch anomaly (HP:0008438)2.32243999
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29838488
79Hypoplasia of the thymus (HP:0000778)2.29523894
80Hematochezia (HP:0002573)2.27627481
81Periodontitis (HP:0000704)2.26459448
82Recurrent gram-negative bacterial infections (HP:0005420)2.24249920
83Pulmonary embolism (HP:0002204)2.20122777
84Increased cerebral lipofuscin (HP:0011813)2.19929559
85Gingival bleeding (HP:0000225)2.18555193
86Autoimmune hemolytic anemia (HP:0001890)2.18048596
87Stomatitis (HP:0010280)2.14373915
88Abnormality of the pleura (HP:0002103)2.12814418
89Ulnar bowing (HP:0003031)2.12430623
90Papilledema (HP:0001085)2.11474552
91Mitral stenosis (HP:0001718)2.09764533
92Abnormality of the prostate (HP:0008775)2.08282109
93Pulmonary infiltrates (HP:0002113)2.07439123
94Abnormality of the peritoneum (HP:0002585)2.07291320
95Optic neuritis (HP:0100653)2.05466259
96Retrobulbar optic neuritis (HP:0100654)2.05466259
97Encephalitis (HP:0002383)2.05429023
98Arterial thrombosis (HP:0004420)2.04489502
99Cheilitis (HP:0100825)2.04067413
100Skin rash (HP:0000988)2.02072077
101Dysostosis multiplex (HP:0000943)2.01788307
102Petechiae (HP:0000967)2.01582939
103Chronic diarrhea (HP:0002028)1.98172474
104Flattened epiphyses (HP:0003071)1.96962185
105Slow saccadic eye movements (HP:0000514)1.96074949
106Gingivitis (HP:0000230)1.95065408
107Leukopenia (HP:0001882)1.94991823
108Gangrene (HP:0100758)1.94516533
109Orchitis (HP:0100796)1.93466040
110Subacute progressive viral hepatitis (HP:0006572)1.92823809
111Arthralgia (HP:0002829)1.91776999
112Hypoproteinemia (HP:0003075)1.91605592
113Spondylolisthesis (HP:0003302)1.91433987
114Agnosia (HP:0010524)1.91377837
115Glomerulopathy (HP:0100820)1.90064609
116Urticaria (HP:0001025)1.89264114
117Neutropenia (HP:0001875)1.87425563
118Hypergammaglobulinemia (HP:0010702)1.85825414
119Viral hepatitis (HP:0006562)1.85526962
120Loss of speech (HP:0002371)1.84558155
121Abnormality of the intervertebral disk (HP:0005108)1.84417199
122Chest pain (HP:0100749)1.84130889
123Increased neuronal autofluorescent lipopigment (HP:0002074)1.82685075
124Global brain atrophy (HP:0002283)1.79988809
125Abnormality of the endocardium (HP:0004306)1.78970456
126Fatigue (HP:0012378)1.78945378
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76157755
128Prolonged bleeding time (HP:0003010)1.74346149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.61539222
2MAP3K104.60032899
3PRPF4B2.97701676
4STK102.85597321
5GRK62.72444607
6BLK2.71846448
7MAP3K142.45332471
8TYK22.27760053
9SYK2.18955829
10BTK2.17710156
11JAK32.14040773
12CSF1R1.96064878
13TBK11.88455213
14MST41.87676847
15RIPK41.83780997
16EEF2K1.81947047
17LRRK21.79976069
18KIT1.78437407
19ERN11.77398078
20ZAP701.77140677
21IKBKE1.67127105
22STK41.66498049
23JAK11.65432690
24ITK1.61107905
25TXK1.58069027
26BMPR21.56414548
27IRAK41.56002615
28IKBKB1.55473572
29MAP3K131.53858304
30CLK11.53481285
31CSK1.48976228
32MARK31.47004691
33HCK1.46566611
34PIM11.43563537
35LCK1.39228008
36SIK21.37866385
37LYN1.37041276
38TEC1.34371898
39PKN21.29492888
40PIK3CG1.26327160
41EPHB11.25190669
42TAOK31.19024527
43CDK121.15795913
44FES1.13139896
45NEK91.11540470
46CDK41.09845915
47TGFBR21.09217100
48MAPK121.08529876
49FGFR31.07865350
50MAP3K31.07081114
51SIK31.01683978
52TRIB31.01059707
53CDC42BPA0.99134312
54NEK20.98631276
55MAP3K10.98453895
56MAP2K30.95751995
57RPS6KA40.91626789
58RPS6KB20.89661065
59CAMKK20.88891653
60TLK10.88393254
61PRKCQ0.86289929
62CDK90.85779708
63TTN0.84774945
64TRPM70.84754439
65NLK0.83455452
66CHUK0.83389008
67IRAK10.80728035
68MAP3K80.79199415
69FGFR40.78723440
70PDPK10.76548426
71KSR20.75838268
72MATK0.75835971
73EIF2AK30.68616646
74IRAK20.66057975
75CDK60.63869710
76MAP3K20.63529443
77TNK20.62156057
78TESK20.62149382
79SMG10.61977326
80SGK30.61857687
81YES10.61563687
82MAP3K70.59934903
83FLT30.59289378
84JAK20.59157458
85DYRK1B0.58968159
86GRK70.58703813
87TAOK10.57133320
88CAMKK10.56484079
89HIPK20.56104358
90SIK10.54467374
91IRAK30.53457902
92MELK0.52931578
93SGK20.52899444
94PTK60.50784912
95ABL10.50611939
96MAPK40.49063799
97ICK0.48772683
98PRKD20.48660143
99FGR0.48560471
100TAOK20.47961419
101MAPKAPK20.47726754
102RPS6KL10.47288951
103RPS6KC10.47288951
104RPS6KA50.46584691
105STK30.46346910
106PBK0.45285870
107PDGFRB0.44942095
108MAP3K110.44897660
109ALK0.42701099
110ZAK0.42655726
111MAPK110.41722598
112STK240.41003858
113FYN0.40953217
114WNK10.40659656
115BRD40.40573300
116INSR0.40271743
117MAP2K20.40002533
118MOS0.39699729
119MAPK70.37892593
120EGFR0.37881359
121PRKCH0.37775130
122PKN10.37378006
123PRKD10.36418094
124PDK10.36202761
125MARK20.35906231
126PRKCD0.34529345
127BMX0.33043855
128DMPK0.32933532
129RPS6KA60.31006602
130CSNK1D0.30475150
131SCYL20.30026170

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.58307869
2B cell receptor signaling pathway_Homo sapiens_hsa046623.44290387
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.65281935
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.61307439
5Leishmaniasis_Homo sapiens_hsa051402.41259247
6Osteoclast differentiation_Homo sapiens_hsa043802.22477315
7Measles_Homo sapiens_hsa051622.03715161
8Hematopoietic cell lineage_Homo sapiens_hsa046402.01987950
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95679106
10Antigen processing and presentation_Homo sapiens_hsa046121.93333810
11Non-homologous end-joining_Homo sapiens_hsa034501.83386327
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82833301
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81056364
14T cell receptor signaling pathway_Homo sapiens_hsa046601.72705883
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71429488
16Allograft rejection_Homo sapiens_hsa053301.64956503
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.55518911
18Graft-versus-host disease_Homo sapiens_hsa053321.52056660
19Herpes simplex infection_Homo sapiens_hsa051681.51374531
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50746642
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49383217
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49223236
23Shigellosis_Homo sapiens_hsa051311.47960194
24Toxoplasmosis_Homo sapiens_hsa051451.46835616
25Chemokine signaling pathway_Homo sapiens_hsa040621.40884868
26Tuberculosis_Homo sapiens_hsa051521.40842632
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.39517193
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36497269
29Chronic myeloid leukemia_Homo sapiens_hsa052201.28594213
30Influenza A_Homo sapiens_hsa051641.28488711
31Viral myocarditis_Homo sapiens_hsa054161.28488158
32Apoptosis_Homo sapiens_hsa042101.26989827
33Hepatitis B_Homo sapiens_hsa051611.26034431
34Malaria_Homo sapiens_hsa051441.22749379
35Systemic lupus erythematosus_Homo sapiens_hsa053221.22176173
36Viral carcinogenesis_Homo sapiens_hsa052031.22053568
37Platelet activation_Homo sapiens_hsa046111.17762428
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16849556
39Acute myeloid leukemia_Homo sapiens_hsa052211.15405099
40Pertussis_Homo sapiens_hsa051331.15366241
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15251482
42TNF signaling pathway_Homo sapiens_hsa046681.14158240
43Pancreatic cancer_Homo sapiens_hsa052121.12986788
44Base excision repair_Homo sapiens_hsa034101.12948942
45Mismatch repair_Homo sapiens_hsa034301.10771508
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09690011
47DNA replication_Homo sapiens_hsa030301.08220242
48Autoimmune thyroid disease_Homo sapiens_hsa053201.07740930
49Salmonella infection_Homo sapiens_hsa051321.05907282
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05602555
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04560147
52Small cell lung cancer_Homo sapiens_hsa052221.03762973
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03566420
54Epstein-Barr virus infection_Homo sapiens_hsa051691.02379047
55Legionellosis_Homo sapiens_hsa051341.00206619
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96354540
57HTLV-I infection_Homo sapiens_hsa051660.95680555
58Non-small cell lung cancer_Homo sapiens_hsa052230.93304311
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86970642
60Asthma_Homo sapiens_hsa053100.85842253
61Dorso-ventral axis formation_Homo sapiens_hsa043200.83444931
62MicroRNAs in cancer_Homo sapiens_hsa052060.82454365
63Hepatitis C_Homo sapiens_hsa051600.82230551
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75511183
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74435045
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.73356081
67p53 signaling pathway_Homo sapiens_hsa041150.72633120
68Staphylococcus aureus infection_Homo sapiens_hsa051500.68907625
69mTOR signaling pathway_Homo sapiens_hsa041500.67874504
70Homologous recombination_Homo sapiens_hsa034400.66075668
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65910940
72VEGF signaling pathway_Homo sapiens_hsa043700.62323124
73Notch signaling pathway_Homo sapiens_hsa043300.61137512
74GnRH signaling pathway_Homo sapiens_hsa049120.60845326
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60535213
76Prolactin signaling pathway_Homo sapiens_hsa049170.59817209
77Renal cell carcinoma_Homo sapiens_hsa052110.59327667
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59076833
79Other glycan degradation_Homo sapiens_hsa005110.58861564
80Endometrial cancer_Homo sapiens_hsa052130.58109983
81Proteoglycans in cancer_Homo sapiens_hsa052050.56011060
82Prostate cancer_Homo sapiens_hsa052150.55663313
83HIF-1 signaling pathway_Homo sapiens_hsa040660.54281913
84Choline metabolism in cancer_Homo sapiens_hsa052310.54134784
85FoxO signaling pathway_Homo sapiens_hsa040680.53405941
86African trypanosomiasis_Homo sapiens_hsa051430.53136294
87Inositol phosphate metabolism_Homo sapiens_hsa005620.52729315
88Endocytosis_Homo sapiens_hsa041440.51980296
89Insulin resistance_Homo sapiens_hsa049310.51520914
90Cell cycle_Homo sapiens_hsa041100.51374994
91Rheumatoid arthritis_Homo sapiens_hsa053230.51085135
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.49914464
93Focal adhesion_Homo sapiens_hsa045100.49905179
94Ribosome_Homo sapiens_hsa030100.49428962
95Lysosome_Homo sapiens_hsa041420.48359996
96Colorectal cancer_Homo sapiens_hsa052100.47696436
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47480888
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.47412047
99Pathways in cancer_Homo sapiens_hsa052000.46523910
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45670857
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44121233
102Type I diabetes mellitus_Homo sapiens_hsa049400.44081617
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.43962051
104Glioma_Homo sapiens_hsa052140.43326844
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.43159818
106ErbB signaling pathway_Homo sapiens_hsa040120.42740726
107MAPK signaling pathway_Homo sapiens_hsa040100.41063422
108Fanconi anemia pathway_Homo sapiens_hsa034600.40984716
109Type II diabetes mellitus_Homo sapiens_hsa049300.40697252
110Spliceosome_Homo sapiens_hsa030400.40076698
111Adherens junction_Homo sapiens_hsa045200.38396345
112Alcoholism_Homo sapiens_hsa050340.34134679
113Bladder cancer_Homo sapiens_hsa052190.33764094
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32920661
115Nucleotide excision repair_Homo sapiens_hsa034200.31942106
116Phagosome_Homo sapiens_hsa041450.31701979
117Amoebiasis_Homo sapiens_hsa051460.30715276

Most similar genes based on co-expression Upload to Enrichr

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