PLEKHA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.90082921
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.29827531
3membrane repolarization during action potential (GO:0086011)5.64952852
4regulation of DNA endoreduplication (GO:0032875)4.98665273
5DNA deamination (GO:0045006)4.93442528
6sulfation (GO:0051923)4.91227128
7behavioral response to nicotine (GO:0035095)4.78387325
8DNA replication checkpoint (GO:0000076)4.76305166
9ribosome assembly (GO:0042255)4.74312923
10magnesium ion transport (GO:0015693)4.72225114
11rRNA modification (GO:0000154)4.66885776
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.65108064
13regulation of skeletal muscle contraction (GO:0014819)4.63084141
14termination of RNA polymerase III transcription (GO:0006386)4.56220422
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.56220422
16proteasome assembly (GO:0043248)4.56150522
17cellular potassium ion homeostasis (GO:0030007)4.49229613
18telomere maintenance via semi-conservative replication (GO:0032201)4.48521944
197-methylguanosine mRNA capping (GO:0006370)4.33225224
20maturation of SSU-rRNA (GO:0030490)4.27988619
217-methylguanosine RNA capping (GO:0009452)4.24750495
22RNA capping (GO:0036260)4.24750495
23cell proliferation in forebrain (GO:0021846)4.20256530
24maturation of 5.8S rRNA (GO:0000460)4.19980481
25positive regulation of potassium ion transmembrane transport (GO:1901381)4.17659330
26mitotic metaphase plate congression (GO:0007080)4.17161705
27ribosome biogenesis (GO:0042254)4.12893237
28telomere maintenance via recombination (GO:0000722)4.12366763
29protein K6-linked ubiquitination (GO:0085020)4.08091356
30DNA strand elongation involved in DNA replication (GO:0006271)4.06630350
31regulation of membrane repolarization (GO:0060306)4.05686227
32ribosomal small subunit biogenesis (GO:0042274)4.05059059
33regulation of mesoderm development (GO:2000380)4.04881714
34ribonucleoprotein complex biogenesis (GO:0022613)4.01223926
35regulation of double-strand break repair via homologous recombination (GO:0010569)4.00312524
36protein-cofactor linkage (GO:0018065)3.99673235
37membrane repolarization (GO:0086009)3.97898936
38cellular response to exogenous dsRNA (GO:0071360)3.97317066
39termination of RNA polymerase I transcription (GO:0006363)3.95894150
40chromatin remodeling at centromere (GO:0031055)3.93228895
41DNA replication initiation (GO:0006270)3.93169468
42kinetochore assembly (GO:0051382)3.92915547
43transcription from RNA polymerase I promoter (GO:0006360)3.91942090
44deoxyribonucleotide biosynthetic process (GO:0009263)3.91900415
45CENP-A containing nucleosome assembly (GO:0034080)3.90435259
46DNA-dependent DNA replication (GO:0006261)3.87509643
47ribosomal large subunit biogenesis (GO:0042273)3.85514028
48transcription-coupled nucleotide-excision repair (GO:0006283)3.85441455
49DNA strand elongation (GO:0022616)3.84694048
50interferon-gamma secretion (GO:0072643)3.83264104
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83251637
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.83251637
53NADH dehydrogenase complex assembly (GO:0010257)3.83251637
54deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.79122426
55water-soluble vitamin biosynthetic process (GO:0042364)3.77654165
56mitochondrial DNA replication (GO:0006264)3.74532631
57mitotic recombination (GO:0006312)3.74509914
58somite development (GO:0061053)3.71744765
59DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.71714279
60dentate gyrus development (GO:0021542)3.70820438
61spliceosomal snRNP assembly (GO:0000387)3.70650492
62protein polyglutamylation (GO:0018095)3.65718311
63rRNA methylation (GO:0031167)3.65303261
64transcription elongation from RNA polymerase I promoter (GO:0006362)3.64899022
65kinetochore organization (GO:0051383)3.62275758
66telomere maintenance via telomere lengthening (GO:0010833)3.62012140
67synaptonemal complex assembly (GO:0007130)3.58025144
68potassium ion import (GO:0010107)3.57035505
69ovulation cycle (GO:0042698)3.53294863
70gamma-aminobutyric acid transport (GO:0015812)3.51198264
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50842953
72piRNA metabolic process (GO:0034587)3.47548249
73regulation of potassium ion transmembrane transport (GO:1901379)3.46243879
74rRNA processing (GO:0006364)3.45948169
75transcription initiation from RNA polymerase I promoter (GO:0006361)3.45210457
76metaphase plate congression (GO:0051310)3.45142782
77cardiovascular system development (GO:0072358)3.44773608
78regulation of mitochondrial translation (GO:0070129)3.44082005
79spliceosomal complex assembly (GO:0000245)3.43768960
80deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.42738953
81purine nucleobase biosynthetic process (GO:0009113)3.40923463
82regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.40808690
83relaxation of cardiac muscle (GO:0055119)3.40614002
84protein complex biogenesis (GO:0070271)3.40611466
85nucleobase biosynthetic process (GO:0046112)3.39890476
86pseudouridine synthesis (GO:0001522)3.38871428
87DNA synthesis involved in DNA repair (GO:0000731)3.38668744
88regulation of centriole replication (GO:0046599)3.38400151
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37685399
90histone exchange (GO:0043486)3.36809981
91rRNA metabolic process (GO:0016072)3.34863420
92negative regulation of systemic arterial blood pressure (GO:0003085)3.30947057
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30419239
94meiotic chromosome segregation (GO:0045132)3.30162691
95histone H4-K12 acetylation (GO:0043983)3.29815073
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.28726063
97positive regulation of cardiac muscle cell differentiation (GO:2000727)3.28367932
98negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.27811458
99regulation of glomerulus development (GO:0090192)3.25190021
100regulation of germinal center formation (GO:0002634)3.24680848
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24264592
102DNA replication-independent nucleosome assembly (GO:0006336)3.24042304
103DNA replication-independent nucleosome organization (GO:0034724)3.24042304
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.23563308
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21873604
106establishment of integrated proviral latency (GO:0075713)3.21338035
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20857197
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20319638
109membrane depolarization during action potential (GO:0086010)3.19541927
110regulation of non-canonical Wnt signaling pathway (GO:2000050)3.19315465
111nucleobase-containing small molecule interconversion (GO:0015949)3.19241212
112synaptonemal complex organization (GO:0070193)3.18383682
113establishment of chromosome localization (GO:0051303)3.17826356
114DNA damage response, detection of DNA damage (GO:0042769)3.17620285
115response to xenobiotic stimulus (GO:0009410)3.17325831
116transcription elongation from RNA polymerase II promoter (GO:0006368)3.17296041
117DNA damage response, signal transduction resulting in transcription (GO:0042772)3.16845697
118RNA methylation (GO:0001510)3.13939943
119attachment of spindle microtubules to kinetochore (GO:0008608)3.12732559
120DNA-templated transcription, termination (GO:0006353)3.10967080
121cellular component biogenesis (GO:0044085)3.10270300
122DNA methylation involved in gamete generation (GO:0043046)3.09903813
123positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.09530338
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09485169
125DNA damage induced protein phosphorylation (GO:0006975)3.08197093
126replicative senescence (GO:0090399)3.07915644
127prostate gland growth (GO:0060736)3.06272488
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04737024
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04737024
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.03752766
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.03752766
132mitochondrial respiratory chain complex assembly (GO:0033108)3.03580896
133positive regulation of viral transcription (GO:0050434)3.01379010
134regulation of heart rate by cardiac conduction (GO:0086091)2.99782272
135DNA replication (GO:0006260)2.99201738
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97235398
137signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97235398
138signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97235398
139activated T cell proliferation (GO:0050798)2.95851690
140retinal ganglion cell axon guidance (GO:0031290)2.95714488
141DNA-templated transcription, elongation (GO:0006354)2.95401707
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94747643
143cell cycle G1/S phase transition (GO:0044843)2.93608136
144G1/S transition of mitotic cell cycle (GO:0000082)2.93608136
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.92237265
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92237265
147parturition (GO:0007567)2.92099637
148signal transduction involved in cell cycle checkpoint (GO:0072395)2.91072537
149serotonin metabolic process (GO:0042428)2.90552881
150formation of translation preinitiation complex (GO:0001731)2.90321032
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.89616622
152negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89471658
153transmission of nerve impulse (GO:0019226)2.89340195
154spindle checkpoint (GO:0031577)2.88731064
155negative regulation of response to food (GO:0032096)2.85184913
156negative regulation of appetite (GO:0032099)2.85184913
157multicellular organismal signaling (GO:0035637)2.80613604
158detection of light stimulus involved in visual perception (GO:0050908)2.79680048
159detection of light stimulus involved in sensory perception (GO:0050962)2.79680048
160primary amino compound metabolic process (GO:1901160)2.77226560
161cellular response to electrical stimulus (GO:0071257)2.76412906
162negative regulation of astrocyte differentiation (GO:0048712)2.75846770
163neuronal action potential (GO:0019228)2.68528353
164action potential (GO:0001508)2.67030842
165interkinetic nuclear migration (GO:0022027)2.65526571
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65096531
167spinal cord development (GO:0021510)2.64955936
168cardiac conduction (GO:0061337)2.64765149
169kidney morphogenesis (GO:0060993)2.64590460
170segment specification (GO:0007379)2.62476696
171otic vesicle formation (GO:0030916)2.61948597
172endoderm formation (GO:0001706)2.61580411
173negative regulation of sodium ion transport (GO:0010766)2.61522492
174positive regulation of glomerulus development (GO:0090193)2.60012097
175positive regulation of potassium ion transport (GO:0043268)2.59747796
176positive regulation of synapse maturation (GO:0090129)2.59418639
177spinal cord motor neuron differentiation (GO:0021522)2.59334080
178cellular response to ATP (GO:0071318)2.57893283
179regulation of potassium ion transport (GO:0043266)2.57639718
180cellular anion homeostasis (GO:0030002)2.57491153
181indolalkylamine metabolic process (GO:0006586)2.56006419
182reflex (GO:0060004)2.55935218
183regulation of synapse maturation (GO:0090128)2.55400729
184adaptation of signaling pathway (GO:0023058)2.54964130
185potassium ion homeostasis (GO:0055075)2.54273012
186flavonoid metabolic process (GO:0009812)2.53664121
187cardiac muscle cell action potential involved in contraction (GO:0086002)2.53655052
188epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52943202
189cardiac muscle cell action potential (GO:0086001)2.51110009
190regulation of gene silencing by RNA (GO:0060966)2.48870039
191regulation of posttranscriptional gene silencing (GO:0060147)2.48870039
192regulation of gene silencing by miRNA (GO:0060964)2.48870039
193negative regulation of potassium ion transmembrane transport (GO:1901380)2.48420433
194pharyngeal system development (GO:0060037)2.47938079
195dendritic spine morphogenesis (GO:0060997)2.43891300
196positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.43407286
197striatum development (GO:0021756)2.43349246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.06545942
2EZH2_22144423_ChIP-Seq_EOC_Human4.52758275
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48273440
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.27573280
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.98051018
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83114831
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.75538137
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50474107
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46192769
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.38138222
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09161056
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99565206
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96098308
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94867120
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.91869369
16GBX2_23144817_ChIP-Seq_PC3_Human2.89898754
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84035436
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78746254
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73959889
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70834959
21VDR_22108803_ChIP-Seq_LS180_Human2.65507784
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62103541
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58337745
24VDR_23849224_ChIP-Seq_CD4+_Human2.56940776
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53352236
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51169061
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50756028
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47031078
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36336182
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34685250
31TAF15_26573619_Chip-Seq_HEK293_Human2.34079419
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32926125
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29252052
34ZNF274_21170338_ChIP-Seq_K562_Hela2.28803105
35STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24330030
36XRN2_22483619_ChIP-Seq_HELA_Human2.20256813
37ELK1_19687146_ChIP-ChIP_HELA_Human2.19463110
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14663166
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13282517
40BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11312683
41EWS_26573619_Chip-Seq_HEK293_Human2.09189680
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07403525
43NANOG_18555785_ChIP-Seq_MESCs_Mouse2.05644647
44POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04087915
45FOXP3_21729870_ChIP-Seq_TREG_Human1.98667873
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.96415754
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.94877905
48TTF2_22483619_ChIP-Seq_HELA_Human1.93757146
49DCP1A_22483619_ChIP-Seq_HELA_Human1.93431952
50FUS_26573619_Chip-Seq_HEK293_Human1.91302339
51P300_19829295_ChIP-Seq_ESCs_Human1.91202448
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90571997
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.87767949
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85958398
55* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85559912
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.84877973
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84119158
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83649892
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.83157825
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81850998
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81386979
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79835245
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78997258
64IGF1R_20145208_ChIP-Seq_DFB_Human1.77933304
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76580998
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75283345
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75283345
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75283345
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74072977
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.72700843
71RNF2_27304074_Chip-Seq_NSC_Mouse1.72649156
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71600845
73GABP_19822575_ChIP-Seq_HepG2_Human1.71390654
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68113551
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67957439
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65067438
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63361152
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63019546
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62942870
80ER_23166858_ChIP-Seq_MCF-7_Human1.59629850
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.57501385
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57442965
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56201646
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56013529
85AR_21909140_ChIP-Seq_LNCAP_Human1.55804682
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.55100966
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54468938
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53854801
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53812367
90SMAD4_21799915_ChIP-Seq_A2780_Human1.53546253
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.52595600
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51619623
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51187846
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49213419
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48557538
96REST_21632747_ChIP-Seq_MESCs_Mouse1.48373234
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47861990
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47662504
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43912255
100STAT3_23295773_ChIP-Seq_U87_Human1.42610428
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41771609
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.40580266
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39833933
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39026899
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38963613
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.38169575
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.37478082
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36789835
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36465640
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36150119
111BCAT_22108803_ChIP-Seq_LS180_Human1.34196295
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34065144
113* AR_25329375_ChIP-Seq_VCAP_Human1.34034179
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33565302
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.33459527
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32568680
117TCF4_23295773_ChIP-Seq_U87_Human1.31867684
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.31808554
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31584196
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30704565
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30704565
122CBP_20019798_ChIP-Seq_JUKART_Human1.26878520
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26878520
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26297062
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25390247
126EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25333345
127RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25333345
128AR_21572438_ChIP-Seq_LNCaP_Human1.20662175
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20229450
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18890396
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18321787
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16949095
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16351856
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.15310863
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14930858
136POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14785827
137MYC_18940864_ChIP-ChIP_HL60_Human1.14091315
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12805621
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.12661197
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12640865
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.12558324
142AHR_22903824_ChIP-Seq_MCF-7_Human1.10834977
143RXR_22108803_ChIP-Seq_LS180_Human1.09636973
144SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08872759
145PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08077390
146MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07867275
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07628177
148KDM5A_27292631_Chip-Seq_BREAST_Human1.07414688
149* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07060225
150STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06234201
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05881253
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04402914
153SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04295471
154* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03908176
155KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03284073
156SMAD4_21741376_ChIP-Seq_EPCs_Human1.02957369
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02831692
158JUN_21703547_ChIP-Seq_K562_Human1.02685297
159NANOG_19829295_ChIP-Seq_ESCs_Human1.02226459
160SOX2_19829295_ChIP-Seq_ESCs_Human1.02226459
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01896640
162KDM2B_26808549_Chip-Seq_REH_Human1.01434943
163TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01350705
164SOX2_21211035_ChIP-Seq_LN229_Gbm1.01334382
165TCF4_22108803_ChIP-Seq_LS180_Human1.00939452
166* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00875318
167RUNX2_22187159_ChIP-Seq_PCA_Human1.00647972
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00417423
169RING1B_27294783_Chip-Seq_ESCs_Mouse1.00115677
170* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99238980
171CIITA_25753668_ChIP-Seq_RAJI_Human0.96622555
172SALL1_21062744_ChIP-ChIP_HESCs_Human0.94682071
173TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93583371
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90871194
175CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90453849
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89646426
177* NANOG_16153702_ChIP-ChIP_HESCs_Human0.86293863
178SOX17_20123909_ChIP-Seq_XEN_Mouse0.84763564
179E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82850438
180FLI1_27457419_Chip-Seq_LIVER_Mouse0.81506871
181CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80602531
182SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80183801
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80116559
184KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79859562
185ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78147620
186GATA1_26923725_Chip-Seq_HPCs_Mouse0.77669872
187SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77550875
188HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75038264
189NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74451917
190TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74250394
191IRF1_19129219_ChIP-ChIP_H3396_Human0.71492409
192OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70867980
193TFEB_21752829_ChIP-Seq_HELA_Human0.70752416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04068139
2MP0003111_abnormal_nucleus_morphology4.31202405
3MP0003646_muscle_fatigue4.23596209
4MP0002837_dystrophic_cardiac_calcinosis4.23142449
5MP0008057_abnormal_DNA_replication4.10497852
6MP0008877_abnormal_DNA_methylation4.07841345
7MP0008058_abnormal_DNA_repair4.05399881
8MP0010094_abnormal_chromosome_stability3.60541526
9MP0003077_abnormal_cell_cycle3.47918192
10MP0004957_abnormal_blastocyst_morpholog3.42464640
11MP0003786_premature_aging3.29588835
12MP0008007_abnormal_cellular_replicative3.02675210
13MP0003718_maternal_effect2.91047794
14MP0001986_abnormal_taste_sensitivity2.80846866
15MP0004885_abnormal_endolymph2.78313550
16MP0008932_abnormal_embryonic_tissue2.70897914
17MP0006292_abnormal_olfactory_placode2.60822076
18MP0005646_abnormal_pituitary_gland2.53406156
19MP0000569_abnormal_digit_pigmentation2.36362396
20MP0002160_abnormal_reproductive_system2.15137104
21MP0005171_absent_coat_pigmentation2.12972108
22MP0008995_early_reproductive_senescence2.12327817
23MP0004130_abnormal_muscle_cell2.10279299
24MP0002210_abnormal_sex_determination2.04937885
25MP0003941_abnormal_skin_development2.04036955
26MP0001440_abnormal_grooming_behavior1.98731510
27MP0000631_abnormal_neuroendocrine_gland1.96260161
28MP0002272_abnormal_nervous_system1.89461161
29MP0001968_abnormal_touch/_nociception1.87894928
30MP0003123_paternal_imprinting1.84468410
31MP0005389_reproductive_system_phenotype1.83501620
32MP0000566_synostosis1.81607372
33MP0009745_abnormal_behavioral_response1.78956638
34MP0004145_abnormal_muscle_electrophysio1.78201089
35MP0009379_abnormal_foot_pigmentation1.77256654
36MP0003890_abnormal_embryonic-extraembry1.75311315
37MP0002277_abnormal_respiratory_mucosa1.74924851
38MP0004142_abnormal_muscle_tone1.73234173
39MP0001188_hyperpigmentation1.71875558
40MP0009250_abnormal_appendicular_skeleto1.70784774
41MP0003136_yellow_coat_color1.67743005
42MP0003315_abnormal_perineum_morphology1.67717127
43MP0001145_abnormal_male_reproductive1.67693198
44MP0000049_abnormal_middle_ear1.67527842
45MP0005551_abnormal_eye_electrophysiolog1.67502519
46MP0002138_abnormal_hepatobiliary_system1.61622478
47MP0002653_abnormal_ependyma_morphology1.60437701
48MP0003283_abnormal_digestive_organ1.56935911
49MP0001929_abnormal_gametogenesis1.55487190
50MP0003186_abnormal_redox_activity1.54502550
51MP0000653_abnormal_sex_gland1.52871222
52MP0005408_hypopigmentation1.52043527
53MP0009053_abnormal_anal_canal1.49044012
54MP0009046_muscle_twitch1.48656699
55MP0001853_heart_inflammation1.47754994
56MP0000372_irregular_coat_pigmentation1.46917023
57MP0003806_abnormal_nucleotide_metabolis1.46727889
58MP0003011_delayed_dark_adaptation1.46195488
59MP0000350_abnormal_cell_proliferation1.44860095
60MP0002064_seizures1.43840158
61MP0004133_heterotaxia1.43442513
62MP0005395_other_phenotype1.42257402
63MP0002736_abnormal_nociception_after1.39316796
64MP0003635_abnormal_synaptic_transmissio1.37579004
65MP0002638_abnormal_pupillary_reflex1.37400191
66MP0005253_abnormal_eye_physiology1.37286679
67MP0002735_abnormal_chemical_nociception1.36524104
68MP0001730_embryonic_growth_arrest1.35569413
69MP0001919_abnormal_reproductive_system1.35380328
70MP0001486_abnormal_startle_reflex1.34760817
71MP0003195_calcinosis1.34094784
72MP0000383_abnormal_hair_follicle1.33248702
73MP0005423_abnormal_somatic_nervous1.32429853
74MP0004134_abnormal_chest_morphology1.30511341
75MP0001119_abnormal_female_reproductive1.28932330
76MP0008872_abnormal_physiological_respon1.28342551
77MP0002572_abnormal_emotion/affect_behav1.25341611
78MP0000313_abnormal_cell_death1.23601752
79MP0002063_abnormal_learning/memory/cond1.23476057
80MP0004742_abnormal_vestibular_system1.23156548
81MP0005645_abnormal_hypothalamus_physiol1.22946062
82MP0005377_hearing/vestibular/ear_phenot1.19821649
83MP0003878_abnormal_ear_physiology1.19821649
84MP0003879_abnormal_hair_cell1.18948945
85MP0002557_abnormal_social/conspecific_i1.18722975
86MP0003880_abnormal_central_pattern1.18708075
87MP0008775_abnormal_heart_ventricle1.16963101
88MP0000778_abnormal_nervous_system1.15422749
89MP0000026_abnormal_inner_ear1.13602550
90MP0002733_abnormal_thermal_nociception1.12414848
91MP0002132_abnormal_respiratory_system1.11086853
92MP0005380_embryogenesis_phenotype1.10877439
93MP0001672_abnormal_embryogenesis/_devel1.10877439
94MP0001970_abnormal_pain_threshold1.09623060
95MP0001502_abnormal_circadian_rhythm1.08586668
96MP0002928_abnormal_bile_duct1.08582705
97MP0010307_abnormal_tumor_latency1.07472171
98MP0002067_abnormal_sensory_capabilities1.04655568
99MP0004215_abnormal_myocardial_fiber1.03977672
100MP0005174_abnormal_tail_pigmentation1.03831354
101MP0002085_abnormal_embryonic_tissue1.03002455
102MP0003787_abnormal_imprinting1.02898913
103MP0001697_abnormal_embryo_size1.01911415
104MP0005084_abnormal_gallbladder_morpholo1.01015001
105MP0001963_abnormal_hearing_physiology0.98359359
106MP0010352_gastrointestinal_tract_polyps0.98113120
107MP0002019_abnormal_tumor_incidence0.97745727
108MP0001905_abnormal_dopamine_level0.97391629
109MP0003698_abnormal_male_reproductive0.97145065
110MP0000230_abnormal_systemic_arterial0.97025582
111MP0002184_abnormal_innervation0.96325468
112MP0001186_pigmentation_phenotype0.96150157
113MP0003938_abnormal_ear_development0.95134372
114MP0003567_abnormal_fetal_cardiomyocyte0.94709722
115MP0004381_abnormal_hair_follicle0.92448513
116MP0005386_behavior/neurological_phenoty0.91557663
117MP0004924_abnormal_behavior0.91557663
118MP0005195_abnormal_posterior_eye0.91292600
119MP0004085_abnormal_heartbeat0.90477061
120MP0002734_abnormal_mechanical_nocicepti0.88165054
121MP0002752_abnormal_somatic_nervous0.88028261
122MP0002234_abnormal_pharynx_morphology0.87767744
123MP0006276_abnormal_autonomic_nervous0.87659145
124MP0004859_abnormal_synaptic_plasticity0.87358603
125MP0001879_abnormal_lymphatic_vessel0.87192620
126MP0000613_abnormal_salivary_gland0.86705843
127MP0005671_abnormal_response_to0.86685790
128MP0008260_abnormal_autophagy0.86487813
129MP0003937_abnormal_limbs/digits/tail_de0.85609867
130MP0003984_embryonic_growth_retardation0.83900610
131MP0000955_abnormal_spinal_cord0.83158354
132MP0002080_prenatal_lethality0.82912528
133MP0004185_abnormal_adipocyte_glucose0.81184573
134MP0002088_abnormal_embryonic_growth/wei0.79298702
135MP0001944_abnormal_pancreas_morphology0.79229062
136MP0001765_abnormal_ion_homeostasis0.79213257
137MP0003942_abnormal_urinary_system0.78963937
138MP0003936_abnormal_reproductive_system0.77919112
139MP0010386_abnormal_urinary_bladder0.77793243
140MP0005384_cellular_phenotype0.77641398
141MP0002102_abnormal_ear_morphology0.77507585
142MP0000427_abnormal_hair_cycle0.77385398
143MP0005075_abnormal_melanosome_morpholog0.76855616
144MP0005621_abnormal_cell_physiology0.75662326
145MP0001286_abnormal_eye_development0.74335749
146MP0002282_abnormal_trachea_morphology0.73892780
147MP0002751_abnormal_autonomic_nervous0.73757580
148MP0001501_abnormal_sleep_pattern0.73732746
149MP0001293_anophthalmia0.73199343
150MP0003119_abnormal_digestive_system0.73195368
151MP0000858_altered_metastatic_potential0.72995889
152MP0003448_altered_tumor_morphology0.72139279
153MP0002932_abnormal_joint_morphology0.71921991
154MP0000015_abnormal_ear_pigmentation0.71853721
155MP0003633_abnormal_nervous_system0.70921454
156MP0000490_abnormal_crypts_of0.70851941
157MP0002163_abnormal_gland_morphology0.67699447
158MP0002111_abnormal_tail_morphology0.67646694
159MP0003699_abnormal_female_reproductive0.66358652
160MP0009333_abnormal_splenocyte_physiolog0.65793303
161MP0008789_abnormal_olfactory_epithelium0.65698259
162MP0001727_abnormal_embryo_implantation0.65409227
163MP0002075_abnormal_coat/hair_pigmentati0.65146334
164MP0006035_abnormal_mitochondrial_morpho0.64213996
165MP0006072_abnormal_retinal_apoptosis0.64124218
166MP0001485_abnormal_pinna_reflex0.63947573
167MP0002876_abnormal_thyroid_physiology0.62155853
168MP0002084_abnormal_developmental_patter0.61482598
169MP0002161_abnormal_fertility/fecundity0.60858991
170MP0000358_abnormal_cell_content/0.60748770
171MP0000762_abnormal_tongue_morphology0.60561657
172MP0000432_abnormal_head_morphology0.59990128
173MP0010030_abnormal_orbit_morphology0.59771541
174MP0002938_white_spotting0.59433549
175MP0003121_genomic_imprinting0.59335264
176MP0003755_abnormal_palate_morphology0.57787723
177MP0002086_abnormal_extraembryonic_tissu0.57402526
178MP0004197_abnormal_fetal_growth/weight/0.55990903
179MP0005409_darkened_coat_color0.54966139
180MP0005266_abnormal_metabolism0.54785169

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.72489514
2Duplicated collecting system (HP:0000081)5.47868375
3Birth length less than 3rd percentile (HP:0003561)5.43271205
4Progressive external ophthalmoplegia (HP:0000590)5.04645802
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.91381439
6Abnormality of the renal collecting system (HP:0004742)4.87070606
7Chromsome breakage (HP:0040012)4.67633814
8Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.56747567
9Conjunctival hamartoma (HP:0100780)3.90282803
10Abnormality of the proximal phalanges of the hand (HP:0009834)3.86781329
11Carpal bone hypoplasia (HP:0001498)3.65118219
12Nephronophthisis (HP:0000090)3.48186899
13True hermaphroditism (HP:0010459)3.41148046
14Genetic anticipation (HP:0003743)3.34926194
15Reticulocytopenia (HP:0001896)3.32422065
16Patellar aplasia (HP:0006443)3.30989202
17Long foot (HP:0001833)3.28468510
18Abnormality of midbrain morphology (HP:0002418)3.26256647
19Molar tooth sign on MRI (HP:0002419)3.26256647
20Progressive cerebellar ataxia (HP:0002073)3.24891688
21Meckel diverticulum (HP:0002245)3.23369676
22Abnormality of the phalanges of the 2nd finger (HP:0009541)3.21655855
23Acute lymphatic leukemia (HP:0006721)3.19343497
24Aplasia/Hypoplasia of the patella (HP:0006498)3.16673173
25Abnormality of the middle phalanges of the toes (HP:0010183)3.10827940
26Short hallux (HP:0010109)3.10476058
27Absent radius (HP:0003974)3.08514538
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08296663
29Ureteral duplication (HP:0000073)3.04030814
30Hamartoma of the eye (HP:0010568)3.00723664
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.99759469
32Abnormal spermatogenesis (HP:0008669)2.98524853
33Abnormality of the ileum (HP:0001549)2.97831759
34Furrowed tongue (HP:0000221)2.97309412
35Abolished electroretinogram (ERG) (HP:0000550)2.95831421
36Aplasia/Hypoplasia of the hallux (HP:0008362)2.93593760
37Aplasia involving forearm bones (HP:0009822)2.91510938
38Absent forearm bone (HP:0003953)2.91510938
39Abnormality of chromosome stability (HP:0003220)2.91298794
40Fibular aplasia (HP:0002990)2.91205702
41Rough bone trabeculation (HP:0100670)2.90242996
42Abnormality of the preputium (HP:0100587)2.90146442
43Abnormality of the renal medulla (HP:0100957)2.89137308
44Stomach cancer (HP:0012126)2.85721018
45Azoospermia (HP:0000027)2.85368867
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.79733962
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.79163613
48Short femoral neck (HP:0100864)2.76689214
49External ophthalmoplegia (HP:0000544)2.73856603
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73850178
51Absent thumb (HP:0009777)2.73281038
52Decreased circulating renin level (HP:0003351)2.69065011
53Aplastic anemia (HP:0001915)2.68055552
54Clubbing of toes (HP:0100760)2.67868246
55Progressive muscle weakness (HP:0003323)2.67075520
56Persistence of primary teeth (HP:0006335)2.66470512
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.65363432
58Aplasia/Hypoplasia of the earlobes (HP:0009906)2.64320271
59Proximal tubulopathy (HP:0000114)2.63859550
60Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.63180577
61Short 1st metacarpal (HP:0010034)2.63180577
62Granulocytopenia (HP:0001913)2.62191948
63Cerebral hypomyelination (HP:0006808)2.58108485
64Supernumerary spleens (HP:0009799)2.57984775
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55714796
66Asplenia (HP:0001746)2.55066368
67Macrocytic anemia (HP:0001972)2.54969135
68Congenital, generalized hypertrichosis (HP:0004540)2.53793941
69Oligodontia (HP:0000677)2.52432477
70Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.51449015
71Small hand (HP:0200055)2.49995938
72Symphalangism affecting the phalanges of the hand (HP:0009773)2.49436390
73Aplasia/Hypoplasia of the fibula (HP:0006492)2.47915561
74Abnormality of the nasal septum (HP:0000419)2.47545063
75Abnormality of cells of the erythroid lineage (HP:0012130)2.45213936
76Meningioma (HP:0002858)2.44240757
77Pendular nystagmus (HP:0012043)2.43051852
78Impulsivity (HP:0100710)2.42864519
79Hypoplasia of the uterus (HP:0000013)2.41753670
80Horseshoe kidney (HP:0000085)2.41365245
81Short tibia (HP:0005736)2.40728536
82Breast aplasia (HP:0100783)2.40611536
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.39818697
84Gaze-evoked nystagmus (HP:0000640)2.37509548
85Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.37421285
86Methylmalonic acidemia (HP:0002912)2.36257835
87Aplasia/Hypoplasia of the breasts (HP:0010311)2.35823106
88Neoplasm of the adrenal cortex (HP:0100641)2.34151794
89Bone marrow hypocellularity (HP:0005528)2.33895430
90Abnormality of the renal cortex (HP:0011035)2.33407743
91Clumsiness (HP:0002312)2.32303270
92Oral leukoplakia (HP:0002745)2.32243561
93Osteomalacia (HP:0002749)2.31615530
94Short 4th metacarpal (HP:0010044)2.30501126
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30501126
96Premature graying of hair (HP:0002216)2.28977576
97Abnormality of the 1st metacarpal (HP:0010009)2.27408333
98Adactyly (HP:0009776)2.26617349
99Hypoplasia of the ulna (HP:0003022)2.26261127
100Cystic liver disease (HP:0006706)2.25183857
101Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.24858820
102Pulmonary artery stenosis (HP:0004415)2.22828904
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21769685
104Microretrognathia (HP:0000308)2.21716342
105Abnormal number of erythroid precursors (HP:0012131)2.21710665
106Septo-optic dysplasia (HP:0100842)2.21527124
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21505070
108Synostosis of carpal bones (HP:0005048)2.21437615
109Abnormal trabecular bone morphology (HP:0100671)2.21367996
110Microvesicular hepatic steatosis (HP:0001414)2.19520919
111Mesomelia (HP:0003027)2.16254744
112Secondary amenorrhea (HP:0000869)2.16111053
113Exercise intolerance (HP:0003546)2.15266889
114Abnormality of DNA repair (HP:0003254)2.15084321
115Abnormality of the labia minora (HP:0012880)2.15080202
116Testicular atrophy (HP:0000029)2.15027785
117Small intestinal stenosis (HP:0012848)2.14804136
118Duodenal stenosis (HP:0100867)2.14804136
119Chronic hepatic failure (HP:0100626)2.14685568
120Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12303806
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12303806
1223-Methylglutaconic aciduria (HP:0003535)2.12137063
123Bone cyst (HP:0012062)2.11512018
124Triphalangeal thumb (HP:0001199)2.10840186
125Cleft eyelid (HP:0000625)2.09629569
126Short thumb (HP:0009778)2.09171235
127Exertional dyspnea (HP:0002875)2.09149269
128Decreased central vision (HP:0007663)2.08529238
129Medial flaring of the eyebrow (HP:0010747)2.05504096
130Megalencephaly (HP:0001355)2.04877214
131Hypoplastic nipples (HP:0002557)2.04837221
132Pancreatic cysts (HP:0001737)2.02826263
133Bony spicule pigmentary retinopathy (HP:0007737)2.02696300
134Glucose intolerance (HP:0000833)2.02688139
135Tubular atrophy (HP:0000092)2.01992134
136Transposition of the great arteries (HP:0001669)2.01920688
137Abnormal connection of the cardiac segments (HP:0011545)2.01920688
138Abnormal ventriculo-arterial connection (HP:0011563)2.01920688
139Abnormal rod and cone electroretinograms (HP:0008323)2.01037759
140Type 2 muscle fiber atrophy (HP:0003554)2.00815373
141Bulbous nose (HP:0000414)1.99788474
14211 pairs of ribs (HP:0000878)1.99144128
143Abnormality of the frontal sinuses (HP:0002687)1.98993436
144Neoplasm of the pancreas (HP:0002894)1.98302535
145Ectopic kidney (HP:0000086)1.97829156
146Congenital sensorineural hearing impairment (HP:0008527)1.97259314
147Attenuation of retinal blood vessels (HP:0007843)1.96363777
148Acute necrotizing encephalopathy (HP:0006965)1.94638954
149Aplasia/hypoplasia of the uterus (HP:0008684)1.94487266
150Abnormality of the 4th metacarpal (HP:0010012)1.93631679
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92689994
152Goiter (HP:0000853)1.92633589
153Renal Fanconi syndrome (HP:0001994)1.92191760
154Hyperventilation (HP:0002883)1.91546657
155Sclerocornea (HP:0000647)1.91296109
156Male pseudohermaphroditism (HP:0000037)1.91129032
157Polydipsia (HP:0001959)1.90392240
158Abnormal drinking behavior (HP:0030082)1.90392240
159Aplasia/Hypoplasia of the ulna (HP:0006495)1.89853066
160Facial cleft (HP:0002006)1.89368540
161Hemiplegia (HP:0002301)1.89323230
1622-3 toe syndactyly (HP:0004691)1.89219655
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89044170
164Absent/shortened dynein arms (HP:0200106)1.88802351
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.88802351
166Increased hepatocellular lipid droplets (HP:0006565)1.88391377
167Myelodysplasia (HP:0002863)1.88382310
168Chorioretinal atrophy (HP:0000533)1.88270928
169Abnormal lung lobation (HP:0002101)1.87898535
170Fibular hypoplasia (HP:0003038)1.87839550
171Increased serum lactate (HP:0002151)1.86726506
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.85908520
173Pancreatic fibrosis (HP:0100732)1.85057779
174Aplasia/hypoplasia of the femur (HP:0005613)1.84872407
175Colon cancer (HP:0003003)1.84546118
176Pallor (HP:0000980)1.83703943
177Keratoconus (HP:0000563)1.82887409
178Increased corneal curvature (HP:0100692)1.82887409
179Anencephaly (HP:0002323)1.82824199
180Short phalanx of the thumb (HP:0009660)1.82768516
181Optic nerve hypoplasia (HP:0000609)1.82300486
182Tracheoesophageal fistula (HP:0002575)1.81718914
183Aplasia/hypoplasia of the humerus (HP:0006507)1.81718110
184Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80939277
185Megaloblastic anemia (HP:0001889)1.80656005
186Methylmalonic aciduria (HP:0012120)1.79777832
187Agitation (HP:0000713)1.78431109
188Type I transferrin isoform profile (HP:0003642)1.78165545
189Pancytopenia (HP:0001876)1.77219973
190Hypoplasia of the radius (HP:0002984)1.76683302
191Abnormality of the duodenum (HP:0002246)1.76175086
192Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75825270
193Congenital stationary night blindness (HP:0007642)1.74758621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.31692529
2IRAK36.08979046
3PLK44.93655300
4BUB14.26832478
5ZAK3.99869250
6IRAK43.02592590
7WEE13.02186879
8STK162.96658976
9GRK12.87226948
10IRAK22.68071024
11SRPK12.66936512
12MARK12.50636350
13ADRBK22.47814203
14TTK2.42383751
15CDC72.26966401
16EIF2AK32.26719511
17IRAK12.18934796
18EIF2AK12.17046668
19TAF12.13299343
20NUAK12.05439186
21CASK2.02629570
22SGK22.02609532
23TAOK31.86192297
24EPHA21.82905235
25STK38L1.81903535
26WNK31.70705846
27INSRR1.69213253
28MAP3K91.68418945
29PLK31.68037775
30MAPK131.65920375
31VRK11.62771344
32PLK11.61798363
33SGK4941.57450611
34SGK2231.57450611
35PINK11.57153788
36MAP3K41.56427685
37WNK41.50912276
38STK391.49551527
39BRSK21.45885659
40NEK91.45504914
41GRK71.43066018
42PBK1.39192542
43TNIK1.36312833
44SGK31.28237786
45NTRK31.25878452
46ACVR1B1.22563069
47ATR1.22462842
48LATS21.22418813
49MAP4K21.20746115
50TSSK61.20684463
51CHEK21.20360417
52TLK11.18052881
53MKNK21.17703474
54PIK3CA1.13040054
55PAK31.12036056
56TESK21.09690777
57EIF2AK21.09653139
58BMPR21.07417905
59NME21.05423420
60FGFR21.05262086
61MKNK11.04820502
62PRKCI1.03413669
63CDC42BPA1.02859447
64AKT31.01635589
65OXSR11.01518651
66PRKCG1.01493944
67ADRBK11.00295300
68ABL21.00238208
69MAP2K70.99920327
70GRK50.97858797
71PHKG10.92832020
72PHKG20.92832020
73PNCK0.92498570
74AURKB0.91442529
75DYRK30.90516015
76SIK20.86522636
77NEK60.84908608
78BRAF0.84055768
79PRKCE0.83951258
80NTRK20.82989816
81NME10.82660603
82CDK70.82179672
83AURKA0.81812618
84CAMKK20.80236019
85NEK10.79824483
86NEK20.79162766
87SGK10.78929849
88BRSK10.77642516
89CSNK1G20.76852990
90DAPK20.76688502
91PRKD20.75704228
92PAK40.75355619
93RPS6KA60.72931651
94CHEK10.71575036
95DYRK20.70591865
96MAPKAPK50.70158319
97TESK10.65624982
98ATM0.64929123
99PRKACA0.64867651
100MAP3K80.64765830
101WNK10.61396709
102CSNK1G10.61272838
103STK110.60740484
104PLK20.59984947
105CAMK1G0.58668817
106STK40.58613723
107MST40.58260815
108CAMK2A0.58022671
109PTK2B0.57774527
110BRD40.57284508
111MAP2K40.56590813
112ERBB20.55975062
113RPS6KA20.54867738
114KDR0.53957055
115CSNK1A1L0.53687968
116CSNK2A10.52767053
117PKN10.52479220
118PRKCQ0.51767818
119DYRK1A0.51674782
120CSNK1A10.51490548
121RPS6KB20.51285902
122IKBKB0.50824146
123HIPK20.49521282
124PRKD30.47183115
125PIM20.46466375
126CDK80.44371384
127CLK10.44002012
128CSNK1G30.43618938
129LATS10.43618545
130MAPK150.43502088
131BLK0.42778065
132PRKCH0.41412407
133CDK20.41148500
134NLK0.40942389
135OBSCN0.40622254
136RPS6KA50.40428402
137CAMK10.39468629
138TGFBR10.39435167
139TIE10.39367412
140CSNK2A20.39114993
141PIM10.38391254
142MAP2K60.38335736
143KIT0.38305735
144PRKAA10.37597626
145RPS6KC10.37368572
146RPS6KL10.37368572
147TRIM280.37364870
148PRKCZ0.37104582
149RPS6KA40.36187635
150CDK10.35697915
151MUSK0.35482316
152STK240.34626289
153BMPR1B0.34014448
154MAPK70.33725058
155PRKACG0.33435027
156PAK10.33347738
157SYK0.33066140
158CCNB10.30993019
159ARAF0.29816462
160STK30.28742022
161YES10.27181790
162CAMK2B0.27175722
163TEC0.25637156
164MAP3K110.25285056
165TAOK20.24771738
166MARK30.24484405
167MELK0.24241317
168TXK0.23206053
169CDK30.22481436
170CAMK2G0.22240258
171CAMK2D0.19756223
172CSNK1E0.19339946
173PRKDC0.17101269
174MAP3K30.14160330
175MAPKAPK30.12797995
176MAP2K20.12641787
177MAPK40.10345260
178MAP3K140.09479767

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.69308813
2DNA replication_Homo sapiens_hsa030304.20324769
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85015590
4Proteasome_Homo sapiens_hsa030503.84835944
5Ribosome_Homo sapiens_hsa030103.76464616
6Mismatch repair_Homo sapiens_hsa034303.60476471
7Fanconi anemia pathway_Homo sapiens_hsa034603.21924411
8Pyrimidine metabolism_Homo sapiens_hsa002403.10402894
9Homologous recombination_Homo sapiens_hsa034403.07865166
10Nicotine addiction_Homo sapiens_hsa050333.01943017
11Spliceosome_Homo sapiens_hsa030402.93672105
12Nucleotide excision repair_Homo sapiens_hsa034202.68773136
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.57933301
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.52061753
15RNA transport_Homo sapiens_hsa030132.51892651
16Basal transcription factors_Homo sapiens_hsa030222.49842734
17Base excision repair_Homo sapiens_hsa034102.35596660
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.23461148
19Cell cycle_Homo sapiens_hsa041102.18480825
20One carbon pool by folate_Homo sapiens_hsa006702.12693089
21RNA degradation_Homo sapiens_hsa030182.05116605
22Morphine addiction_Homo sapiens_hsa050321.96681281
23Purine metabolism_Homo sapiens_hsa002301.92933690
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84330394
25p53 signaling pathway_Homo sapiens_hsa041151.75973054
26Oxidative phosphorylation_Homo sapiens_hsa001901.75417230
27Insulin secretion_Homo sapiens_hsa049111.74651108
28Circadian entrainment_Homo sapiens_hsa047131.70443720
29Glutamatergic synapse_Homo sapiens_hsa047241.68559131
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65394556
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63927286
32Huntingtons disease_Homo sapiens_hsa050161.62231144
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62183192
34Nitrogen metabolism_Homo sapiens_hsa009101.57428634
35Taste transduction_Homo sapiens_hsa047421.55509759
36Type II diabetes mellitus_Homo sapiens_hsa049301.53941213
37Non-homologous end-joining_Homo sapiens_hsa034501.53580523
38Dorso-ventral axis formation_Homo sapiens_hsa043201.50396478
39Parkinsons disease_Homo sapiens_hsa050121.50307649
40Renin secretion_Homo sapiens_hsa049241.47523520
41Cholinergic synapse_Homo sapiens_hsa047251.47001738
42Serotonergic synapse_Homo sapiens_hsa047261.44835632
43Sulfur metabolism_Homo sapiens_hsa009201.44726249
44GABAergic synapse_Homo sapiens_hsa047271.39158288
45Gastric acid secretion_Homo sapiens_hsa049711.30944515
46Olfactory transduction_Homo sapiens_hsa047401.29796380
47Retinol metabolism_Homo sapiens_hsa008301.28184358
48Epstein-Barr virus infection_Homo sapiens_hsa051691.27210248
49Protein export_Homo sapiens_hsa030601.25838692
50mRNA surveillance pathway_Homo sapiens_hsa030151.25326132
51Caffeine metabolism_Homo sapiens_hsa002321.23985546
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.19865445
53Chemical carcinogenesis_Homo sapiens_hsa052041.17956604
54Tryptophan metabolism_Homo sapiens_hsa003801.15571634
55Dopaminergic synapse_Homo sapiens_hsa047281.14084513
56Selenocompound metabolism_Homo sapiens_hsa004501.13618923
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13462331
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10176944
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08431265
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08382474
61Hedgehog signaling pathway_Homo sapiens_hsa043401.07568992
62Amphetamine addiction_Homo sapiens_hsa050311.06772902
63Oxytocin signaling pathway_Homo sapiens_hsa049211.06557516
64Glutathione metabolism_Homo sapiens_hsa004801.05973491
65Calcium signaling pathway_Homo sapiens_hsa040201.03778844
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01463596
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99974328
68Melanoma_Homo sapiens_hsa052180.97842426
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96530618
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96419577
71Cocaine addiction_Homo sapiens_hsa050300.92727524
72Salivary secretion_Homo sapiens_hsa049700.90194831
73Arachidonic acid metabolism_Homo sapiens_hsa005900.89983075
74Butanoate metabolism_Homo sapiens_hsa006500.85606882
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83650844
76Basal cell carcinoma_Homo sapiens_hsa052170.83374172
77Alzheimers disease_Homo sapiens_hsa050100.83210267
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82894578
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82459237
80Glycerolipid metabolism_Homo sapiens_hsa005610.81829492
81cAMP signaling pathway_Homo sapiens_hsa040240.80619516
82Phototransduction_Homo sapiens_hsa047440.79831878
83Vitamin B6 metabolism_Homo sapiens_hsa007500.79510779
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79272587
85Ovarian steroidogenesis_Homo sapiens_hsa049130.75385461
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74648820
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73240695
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71954769
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70020089
90Alcoholism_Homo sapiens_hsa050340.67756898
91Folate biosynthesis_Homo sapiens_hsa007900.67462005
92Circadian rhythm_Homo sapiens_hsa047100.67425731
93MAPK signaling pathway_Homo sapiens_hsa040100.67384463
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.67350427
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.64863350
96Long-term depression_Homo sapiens_hsa047300.63829936
97Linoleic acid metabolism_Homo sapiens_hsa005910.63392248
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.62991314
99Herpes simplex infection_Homo sapiens_hsa051680.62257723
100Systemic lupus erythematosus_Homo sapiens_hsa053220.61898602
101ABC transporters_Homo sapiens_hsa020100.61722545
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.60930763
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.59349696
104Oocyte meiosis_Homo sapiens_hsa041140.59292380
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58684220
106Primary immunodeficiency_Homo sapiens_hsa053400.55471997
107Long-term potentiation_Homo sapiens_hsa047200.52696837
108Pentose phosphate pathway_Homo sapiens_hsa000300.52070532
109Metabolic pathways_Homo sapiens_hsa011000.49892753
110Peroxisome_Homo sapiens_hsa041460.49395654
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48337389
112Insulin resistance_Homo sapiens_hsa049310.47721619
113Sphingolipid metabolism_Homo sapiens_hsa006000.45917150
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45349485
115Regulation of autophagy_Homo sapiens_hsa041400.43809626
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42654399
117Viral carcinogenesis_Homo sapiens_hsa052030.41832697
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41478444
119Phenylalanine metabolism_Homo sapiens_hsa003600.41350115
120Wnt signaling pathway_Homo sapiens_hsa043100.40874674
121Mineral absorption_Homo sapiens_hsa049780.40523113
122Graft-versus-host disease_Homo sapiens_hsa053320.38946511
123HTLV-I infection_Homo sapiens_hsa051660.38395521
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38234855
125Ras signaling pathway_Homo sapiens_hsa040140.37425592
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36833908
127Tyrosine metabolism_Homo sapiens_hsa003500.36344405
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35021788
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32903001
130Arginine and proline metabolism_Homo sapiens_hsa003300.32825800
131Other glycan degradation_Homo sapiens_hsa005110.32460988
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32431635
133TGF-beta signaling pathway_Homo sapiens_hsa043500.32303667
134Asthma_Homo sapiens_hsa053100.29414408
135Ether lipid metabolism_Homo sapiens_hsa005650.28423424
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.27013859
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24999355
138Autoimmune thyroid disease_Homo sapiens_hsa053200.24473171
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23517586
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21292378
141Measles_Homo sapiens_hsa051620.20933739
142Antigen processing and presentation_Homo sapiens_hsa046120.18573272
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18433768
144Apoptosis_Homo sapiens_hsa042100.18348962
145Allograft rejection_Homo sapiens_hsa053300.16657106
146Collecting duct acid secretion_Homo sapiens_hsa049660.16256875
147Rheumatoid arthritis_Homo sapiens_hsa053230.14288711
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13043831
149Shigellosis_Homo sapiens_hsa051310.12778289
150Renin-angiotensin system_Homo sapiens_hsa046140.11397355
151Influenza A_Homo sapiens_hsa051640.11335345
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11100392
153MicroRNAs in cancer_Homo sapiens_hsa052060.09261597
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08858163
155Fructose and mannose metabolism_Homo sapiens_hsa000510.08724834
156Intestinal immune network for IgA production_Homo sapiens_hsa046720.08570898
157Biosynthesis of amino acids_Homo sapiens_hsa012300.08499693
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08446092
159Legionellosis_Homo sapiens_hsa051340.08387285
160Small cell lung cancer_Homo sapiens_hsa052220.07791073
161Cardiac muscle contraction_Homo sapiens_hsa042600.07727785
162Vitamin digestion and absorption_Homo sapiens_hsa049770.07273457
163Galactose metabolism_Homo sapiens_hsa000520.07206249
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06558902
165Thyroid cancer_Homo sapiens_hsa052160.06056291
166Glycosaminoglycan degradation_Homo sapiens_hsa005310.05232326
167Hippo signaling pathway_Homo sapiens_hsa043900.03915264

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »