PLEKHA3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myeloid dendritic cell differentiation (GO:0043011)5.86028671
2cytidine deamination (GO:0009972)5.54178363
3cytidine metabolic process (GO:0046087)5.54178363
4cytidine catabolic process (GO:0006216)5.54178363
5hematopoietic stem cell differentiation (GO:0060218)5.51286396
6regulation of interleukin-6 biosynthetic process (GO:0045408)5.40625626
7myeloid dendritic cell activation (GO:0001773)5.36512404
8T-helper 1 type immune response (GO:0042088)5.13981457
9pyrimidine ribonucleoside catabolic process (GO:0046133)5.10418588
10positive regulation of osteoclast differentiation (GO:0045672)4.95898146
11positive regulation of T cell cytokine production (GO:0002726)4.95228486
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.77701713
13regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.74303916
14regulation of interleukin-8 biosynthetic process (GO:0045414)4.72061871
15regulation of immunoglobulin secretion (GO:0051023)4.59621063
16autophagic vacuole fusion (GO:0000046)4.43015156
17mRNA modification (GO:0016556)4.42393152
18natural killer cell differentiation (GO:0001779)4.40055540
19negative regulation of thymocyte apoptotic process (GO:0070244)4.11123430
20organelle membrane fusion (GO:0090174)3.95425072
21regulation of interleukin-2 biosynthetic process (GO:0045076)3.92498488
22seminiferous tubule development (GO:0072520)3.88607585
23DNA deamination (GO:0045006)3.86270004
24positive regulation of protein homooligomerization (GO:0032464)3.82513987
25cytokine biosynthetic process (GO:0042089)3.77234094
26Peyers patch development (GO:0048541)3.71819870
27mucosal-associated lymphoid tissue development (GO:0048537)3.71819870
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.66977898
29positive regulation of myeloid leukocyte differentiation (GO:0002763)3.60239221
30positive regulation of gamma-delta T cell activation (GO:0046645)3.58959035
31positive regulation of granulocyte differentiation (GO:0030854)3.53125675
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.49956167
33protein targeting to Golgi (GO:0000042)3.42769652
34positive regulation of transcription regulatory region DNA binding (GO:2000679)3.41714199
35establishment of protein localization to Golgi (GO:0072600)3.41123452
36dendritic cell differentiation (GO:0097028)3.40052575
37membrane protein intracellular domain proteolysis (GO:0031293)3.35656190
38purine-containing compound salvage (GO:0043101)3.35149392
39positive regulation of defense response to virus by host (GO:0002230)3.31338648
40alpha-beta T cell differentiation (GO:0046632)3.26835891
41regulation of T cell cytokine production (GO:0002724)3.22371080
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21416515
43regulation of B cell differentiation (GO:0045577)3.17565626
44chaperone mediated protein folding requiring cofactor (GO:0051085)3.13772688
45sterol catabolic process (GO:0016127)3.13331284
46cholesterol catabolic process (GO:0006707)3.13331284
47cytokine metabolic process (GO:0042107)3.13287418
48regulation of interleukin-2 production (GO:0032663)3.12829924
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07130197
50alpha-beta T cell activation (GO:0046631)3.04563865
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04491774
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01383403
53regulation of telomere maintenance via telomerase (GO:0032210)2.99919677
54positive regulation of interleukin-2 production (GO:0032743)2.98451206
55defense response to protozoan (GO:0042832)2.96423540
56negative regulation of T cell apoptotic process (GO:0070233)2.95975728
57antigen processing and presentation of endogenous antigen (GO:0019883)2.94840513
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94835845
59regulation of thymocyte apoptotic process (GO:0070243)2.87678363
60COPII vesicle coating (GO:0048208)2.86708115
61DNA double-strand break processing (GO:0000729)2.86538038
62regulation of B cell receptor signaling pathway (GO:0050855)2.84639882
63negative regulation of bone resorption (GO:0045779)2.80985339
64cellular response to nerve growth factor stimulus (GO:1990090)2.78988388
65response to nerve growth factor (GO:1990089)2.78988388
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78953728
67negative regulation of T-helper cell differentiation (GO:0045623)2.78953728
68entrainment of circadian clock by photoperiod (GO:0043153)2.76853432
69response to interleukin-15 (GO:0070672)2.74570118
70viral protein processing (GO:0019082)2.73778415
71actin nucleation (GO:0045010)2.73762071
72B cell receptor signaling pathway (GO:0050853)2.73262962
73response to protozoan (GO:0001562)2.71803682
74nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.67855311
75positive regulation of T cell mediated immunity (GO:0002711)2.67612022
76neutrophil activation involved in immune response (GO:0002283)2.63331961
77NIK/NF-kappaB signaling (GO:0038061)2.61972325
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61789109
79positive regulation of B cell differentiation (GO:0045579)2.61366584
80positive regulation of myeloid cell differentiation (GO:0045639)2.61147044
81interleukin-1-mediated signaling pathway (GO:0070498)2.60140587
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58455402
83entrainment of circadian clock (GO:0009649)2.58428357
84T-helper cell differentiation (GO:0042093)2.54620446
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.54620446
86regulation of gamma-delta T cell differentiation (GO:0045586)2.53668774
87negative regulation of telomere maintenance (GO:0032205)2.51158701
88natural killer cell activation (GO:0030101)2.47529262
89regulation of granulocyte differentiation (GO:0030852)2.47415809
90response to type I interferon (GO:0034340)2.47185190
91regulation of T cell mediated immunity (GO:0002709)2.47095542
92cellular response to type I interferon (GO:0071357)2.46850890
93type I interferon signaling pathway (GO:0060337)2.46850890
94regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.45608569
95regulation of gamma-delta T cell activation (GO:0046643)2.45105864
96signal peptide processing (GO:0006465)2.42765523
97poly(A)+ mRNA export from nucleus (GO:0016973)2.42493371
98regulation of immunoglobulin production (GO:0002637)2.42363084
99negative regulation of lymphocyte apoptotic process (GO:0070229)2.42011870
100regulation of cytokine production involved in inflammatory response (GO:1900015)12.0592610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.82897992
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.56701712
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.45617907
4RUNX_20019798_ChIP-Seq_JUKART_Human3.50609434
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20405082
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11042001
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02633171
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.97779834
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.86233881
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.72453104
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.63330152
12ZNF274_21170338_ChIP-Seq_K562_Hela2.57339679
13SCL_19346495_ChIP-Seq_HPC-7_Human2.53690414
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50162407
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44881051
16MYB_26560356_Chip-Seq_TH2_Human2.38254000
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.33565043
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.13069262
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09171084
20MYC_22102868_ChIP-Seq_BL_Human2.04626911
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02807738
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95590281
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95515412
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90944202
25MYB_26560356_Chip-Seq_TH1_Human1.89379777
26VDR_23849224_ChIP-Seq_CD4+_Human1.88602342
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72270305
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66809333
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63253801
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.63215551
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62841837
32SPI1_23547873_ChIP-Seq_NB4_Human1.62263448
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61826354
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.58944959
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.53286986
36FOXP3_21729870_ChIP-Seq_TREG_Human1.50691697
37GATA3_27048872_Chip-Seq_THYMUS_Human1.44966442
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42792950
39GATA3_26560356_Chip-Seq_TH2_Human1.42635924
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41500370
41MAF_26560356_Chip-Seq_TH1_Human1.41409244
42UTX_26944678_Chip-Seq_JUKART_Human1.36778494
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.33548630
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30118563
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.29843078
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29433607
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29148175
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27759043
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24630926
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.22396291
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20880191
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.14843975
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14456060
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13023099
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13015914
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12953036
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12953036
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12953036
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11879346
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11400817
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10857310
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10692904
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09841353
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08955427
65P300_18555785_Chip-Seq_ESCs_Mouse1.08768825
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08264376
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.05875405
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.05732131
69MAF_26560356_Chip-Seq_TH2_Human1.05226068
70SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03346817
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02342420
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00883538
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.00775869
74PU_27001747_Chip-Seq_BMDM_Mouse1.00626033
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98952577
76BCL6_27268052_Chip-Seq_Bcells_Human0.98785761
77CIITA_25753668_ChIP-Seq_RAJI_Human0.96684454
78ETS1_20019798_ChIP-Seq_JURKAT_Human0.96594607
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95382425
80ELK1_19687146_ChIP-ChIP_HELA_Human0.95315931
81OCT4_18555785_Chip-Seq_ESCs_Mouse0.94855972
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94542258
83VDR_24763502_ChIP-Seq_THP-1_Human0.94272446
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.94045684
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93230914
86CTCF_18555785_Chip-Seq_ESCs_Mouse0.92722403
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.91843504
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91824899
89MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91451344
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.91291591
91SPI1_23127762_ChIP-Seq_K562_Human0.90758876
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90705835
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90673642
94DCP1A_22483619_ChIP-Seq_HELA_Human0.90191680
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90095915
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88916845
97CEBPB_22108803_ChIP-Seq_LS180_Human0.87890409
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87061530
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.86849628
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85644982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation4.42526512
2MP0008004_abnormal_stomach_pH4.22133646
3MP0001790_abnormal_immune_system4.12809367
4MP0005387_immune_system_phenotype4.12809367
5MP0009785_altered_susceptibility_to4.03796993
6MP0000013_abnormal_adipose_tissue3.91541846
7MP0005671_abnormal_response_to3.90838465
8MP0003436_decreased_susceptibility_to3.57750962
9MP0002148_abnormal_hypersensitivity_rea3.03095921
10MP0001835_abnormal_antigen_presentation2.94366792
11MP0001800_abnormal_humoral_immune2.51462164
12MP0005000_abnormal_immune_tolerance2.48043176
13MP0000003_abnormal_adipose_tissue2.41378624
14MP0002723_abnormal_immune_serum2.22779494
15MP0009278_abnormal_bone_marrow2.13932971
16MP0010155_abnormal_intestine_physiology2.13181114
17MP0009333_abnormal_splenocyte_physiolog2.07415869
18MP0005025_abnormal_response_to2.07064044
19MP0003763_abnormal_thymus_physiology1.98701693
20MP0002452_abnormal_antigen_presenting1.95856498
21MP0002405_respiratory_system_inflammati1.93711112
22MP0002420_abnormal_adaptive_immunity1.84934547
23MP0001819_abnormal_immune_cell1.82199002
24MP0003724_increased_susceptibility_to1.69015378
25MP0005310_abnormal_salivary_gland1.59321235
26MP0000685_abnormal_immune_system1.58974200
27MP0000716_abnormal_immune_system1.57918688
28MP0002398_abnormal_bone_marrow1.54095950
29MP0003303_peritoneal_inflammation1.53728422
30MP0001849_ear_inflammation1.49129694
31MP0005379_endocrine/exocrine_gland_phen1.47792489
32MP0001853_heart_inflammation1.45879106
33MP0003172_abnormal_lysosome_physiology1.43309874
34MP0001873_stomach_inflammation1.39545677
35MP0002722_abnormal_immune_system1.38078487
36MP0001533_abnormal_skeleton_physiology1.35177150
37MP0008873_increased_physiological_sensi1.31551779
38MP0000689_abnormal_spleen_morphology1.28567831
39MP0002429_abnormal_blood_cell1.24338577
40MP0001845_abnormal_inflammatory_respons1.22949228
41MP0002419_abnormal_innate_immunity1.21519956
42MP0001502_abnormal_circadian_rhythm1.21271160
43MP0008469_abnormal_protein_level1.20479377
44MP0002277_abnormal_respiratory_mucosa1.19101766
45MP0003300_gastrointestinal_ulcer1.16939604
46MP0005464_abnormal_platelet_physiology1.16398370
47MP0002102_abnormal_ear_morphology1.10559202
48MP0005410_abnormal_fertilization1.08277427
49MP0004510_myositis1.07382493
50MP0000703_abnormal_thymus_morphology1.06464248
51MP0001545_abnormal_hematopoietic_system1.06410764
52MP0005397_hematopoietic_system_phenotyp1.06410764
53MP0002138_abnormal_hepatobiliary_system1.05578079
54MP0005375_adipose_tissue_phenotype1.03425100
55MP0008875_abnormal_xenobiotic_pharmacok1.02044964
56MP0000371_diluted_coat_color1.01372059
57MP0009764_decreased_sensitivity_to1.00409274
58MP0002693_abnormal_pancreas_physiology0.99526879
59MP0003866_abnormal_defecation0.98252934
60MP0001986_abnormal_taste_sensitivity0.96574654
61MP0008961_abnormal_basal_metabolism0.96035904
62MP0001348_abnormal_lacrimal_gland0.94460321
63MP0002095_abnormal_skin_pigmentation0.93941954
64MP0002166_altered_tumor_susceptibility0.93288358
65MP0003011_delayed_dark_adaptation0.92211952
66MP0003195_calcinosis0.90987153
67MP0003943_abnormal_hepatobiliary_system0.89016850
68MP0004808_abnormal_hematopoietic_stem0.87338076
69MP0005584_abnormal_enzyme/coenzyme_acti0.85763345
70MP0001501_abnormal_sleep_pattern0.85323287
71MP0002822_catalepsy0.82530019
72MP0002998_abnormal_bone_remodeling0.79376880
73MP0004019_abnormal_vitamin_homeostasis0.79281942
74MP0000627_abnormal_mammary_gland0.79248378
75MP0001764_abnormal_homeostasis0.79125393
76MP0006082_CNS_inflammation0.75270961
77MP0005646_abnormal_pituitary_gland0.73393955
78MP0000490_abnormal_crypts_of0.72354978
79MP0005187_abnormal_penis_morphology0.69973020
80MP0002736_abnormal_nociception_after0.69360294
81MP0009931_abnormal_skin_appearance0.67975763
82MP0001968_abnormal_touch/_nociception0.66766042
83MP0001881_abnormal_mammary_gland0.66701433
84MP0005319_abnormal_enzyme/_coenzyme0.65992836
85MP0008874_decreased_physiological_sensi0.65784235
86MP0003191_abnormal_cellular_cholesterol0.62419587
87MP0003221_abnormal_cardiomyocyte_apopto0.60433487
88MP0002078_abnormal_glucose_homeostasis0.60349673
89MP0001765_abnormal_ion_homeostasis0.58490516
90MP0000609_abnormal_liver_physiology0.58483249
91MP0003786_premature_aging0.57470239
92MP0005076_abnormal_cell_differentiation0.56988826
93MP0001529_abnormal_vocalization0.56883803
94MP0001663_abnormal_digestive_system0.55422989
95MP0000465_gastrointestinal_hemorrhage0.55233289
96MP0003787_abnormal_imprinting0.54050927
97MP0004134_abnormal_chest_morphology0.54024847
98MP0001944_abnormal_pancreas_morphology0.53521076
99MP0005645_abnormal_hypothalamus_physiol0.53506533
100MP0000470_abnormal_stomach_morphology0.53315856

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.10791029
2Myositis (HP:0100614)4.58598208
3Retrobulbar optic neuritis (HP:0100654)4.56512553
4Optic neuritis (HP:0100653)4.56512553
5Keratoconjunctivitis sicca (HP:0001097)4.29833001
6Chronic mucocutaneous candidiasis (HP:0002728)4.28953790
7Recurrent cutaneous fungal infections (HP:0011370)4.28953790
8Keratoconjunctivitis (HP:0001096)4.17010350
9Hemoptysis (HP:0002105)3.65540225
10Recurrent fungal infections (HP:0002841)3.40278931
11Periodontitis (HP:0000704)3.36743182
12Increased hepatocellular lipid droplets (HP:0006565)3.31023349
13Premature loss of primary teeth (HP:0006323)3.28533586
14Cheilitis (HP:0100825)3.27797360
15Elevated erythrocyte sedimentation rate (HP:0003565)3.25431155
16Renal cortical cysts (HP:0000803)3.20977631
17Hypoplasia of the fovea (HP:0007750)3.20432657
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.20432657
19Autoimmune thrombocytopenia (HP:0001973)3.16744508
20Lipid accumulation in hepatocytes (HP:0006561)3.12111408
21Renal Fanconi syndrome (HP:0001994)3.09946516
22Hypothermia (HP:0002045)3.08215520
23Autoimmune hemolytic anemia (HP:0001890)3.05572751
24Methylmalonic acidemia (HP:0002912)3.04325586
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02762882
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02762882
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96683781
28Panhypogammaglobulinemia (HP:0003139)2.95757177
29Vasculitis (HP:0002633)2.95061677
30Abnormality of the renal cortex (HP:0011035)2.84467749
31Methylmalonic aciduria (HP:0012120)2.82602477
32Increased mean platelet volume (HP:0011877)2.81488074
33Abnormality of the fovea (HP:0000493)2.80212131
34Generalized hypopigmentation of hair (HP:0011358)2.79157820
35Severe combined immunodeficiency (HP:0004430)2.78191923
36Abnormal platelet volume (HP:0011876)2.77683321
37Lymphopenia (HP:0001888)2.75945133
38Encephalitis (HP:0002383)2.68526859
39Lower limb hyperreflexia (HP:0002395)2.66523124
40Thrombocytosis (HP:0001894)2.63376181
41Hypoalbuminemia (HP:0003073)2.60176391
42Abnormal albumin level (HP:0012116)2.60176391
43Increased intramyocellular lipid droplets (HP:0012240)2.59258556
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.57680931
45Stomatitis (HP:0010280)2.55003396
46Meningitis (HP:0001287)2.53332188
47Abnormality of B cell number (HP:0010975)2.52802312
48Malignant hyperthermia (HP:0002047)2.51324963
49Recurrent skin infections (HP:0001581)2.50879201
50Pulmonary infiltrates (HP:0002113)2.50708429
51Generalized aminoaciduria (HP:0002909)2.42777873
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.42042173
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41237829
54Abnormality of endocrine pancreas physiology (HP:0012093)2.41019255
55Abnormality of the pancreatic islet cells (HP:0006476)2.41019255
56Hypokalemic alkalosis (HP:0001949)2.37045497
57Abnormality of the pleura (HP:0002103)2.35790310
58Increased muscle lipid content (HP:0009058)2.33987749
59Abnormality of methionine metabolism (HP:0010901)2.31732646
60Bifid uvula (HP:0000193)2.30421601
61Abnormality of T cells (HP:0002843)2.27765686
62Villous atrophy (HP:0011473)2.26393028
63Abnormality of small intestinal villus morphology (HP:0011472)2.26393028
64Hypoplasia of the thymus (HP:0000778)2.24018328
65Leukocytosis (HP:0001974)2.22402588
66Median cleft lip (HP:0000161)2.22297935
67Combined immunodeficiency (HP:0005387)2.21297714
68Pancreatic islet-cell hyperplasia (HP:0004510)2.20661821
69Aplastic anemia (HP:0001915)2.18337951
70Loss of speech (HP:0002371)2.16769022
71Ketoacidosis (HP:0001993)2.13741714
72Exertional dyspnea (HP:0002875)2.13565699
73Abnormality of T cell number (HP:0011839)2.12370926
74Flat capital femoral epiphysis (HP:0003370)2.11834131
75Recurrent sinusitis (HP:0011108)2.10660899
76Polyneuropathy (HP:0001271)2.10374640
77Gangrene (HP:0100758)2.10175573
78Flattened epiphyses (HP:0003071)2.10011102
79Anterior segment dysgenesis (HP:0007700)2.09095211
80Anorexia (HP:0002039)2.07755457
81B lymphocytopenia (HP:0010976)2.06341080
82Tetraparesis (HP:0002273)2.04090424
83Abnormality of T cell physiology (HP:0011840)2.00435792
84Prominent supraorbital ridges (HP:0000336)1.98255938
85Keratitis (HP:0000491)1.96777279
86Nonimmune hydrops fetalis (HP:0001790)1.95669738
87Increased IgM level (HP:0003496)1.94912099
88Skin rash (HP:0000988)1.94854737
89Xerostomia (HP:0000217)1.91303536
90Abnormality of eosinophils (HP:0001879)1.90869548
91Portal hypertension (HP:0001409)1.89899433
92Acute hepatic failure (HP:0006554)1.89530303
93T lymphocytopenia (HP:0005403)1.89098438
94IgM deficiency (HP:0002850)1.87688088
95Metabolic alkalosis (HP:0200114)1.87325419
96Chronic otitis media (HP:0000389)1.87287971
97Glomerulopathy (HP:0100820)1.86385803
98Recurrent viral infections (HP:0004429)1.85720102
99Eosinophilia (HP:0001880)1.84076250
100Aplasia/Hypoplasia of the macula (HP:0008059)1.83520849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.56934462
2ZAK5.05535531
3BCKDK4.98883323
4CASK3.66960558
5ERN13.49401286
6MST42.91492412
7TXK2.65638969
8ACVR1B2.22574887
9JAK32.19184800
10MAP4K12.11703039
11MAP2K62.07877200
12VRK11.96747996
13MAP3K141.93758593
14NEK11.78396441
15WNK41.71337139
16MAPKAPK51.63583192
17JAK11.61270552
18STK391.59059706
19PHKG21.56788565
20PHKG11.56788565
21KDR1.55239546
22CDK121.53747736
23TNK21.48117113
24FLT31.38655496
25TYK21.31895042
26PRKCQ1.28946207
27PRPF4B1.17483264
28DAPK21.13218013
29TSSK61.11537174
30KIT1.10941021
31ADRBK21.08960939
32TAOK31.04948004
33CSF1R1.04422576
34PIM11.04238530
35CCNB11.04112734
36MAP3K11.02573805
37JAK21.01213600
38CLK11.00764559
39IKBKE0.98760294
40CAMKK20.96732366
41OXSR10.96594961
42STK100.93441756
43MAP3K120.89361984
44FES0.85146507
45SYK0.83399332
46LCK0.82845145
47HIPK20.82607382
48IKBKB0.81227965
49EPHA30.76889947
50TAOK20.76306512
51IRAK10.73805178
52CDK40.67996286
53TBK10.67846928
54WNK10.64873590
55CHUK0.63492469
56LRRK20.62530187
57PRKCH0.62149386
58RPS6KA50.62098885
59MAP3K50.60714900
60SIK20.60706327
61PASK0.60061479
62MAP3K110.56558939
63PKN10.53914712
64CAMKK10.47146518
65BTK0.41297757
66LYN0.40844557
67BLK0.40733192
68HCK0.39674659
69GRK70.39521684
70TEC0.37545300
71MAPK130.37195966
72MAPK140.36266890
73MATK0.35879425
74MAP2K30.34291795
75CSK0.33205389
76SIK30.32821296
77AKT20.31466475
78RPS6KB10.31071313
79RPS6KC10.30819838
80RPS6KL10.30819838
81RPS6KA60.30493296
82MAP3K130.29710187
83BMX0.29160956
84PDK10.27660032
85PRKCD0.26558425
86IRAK40.26465938
87TIE10.25889601
88DAPK10.25671275
89NME20.24685799
90ITK0.23533624
91MAPK90.22805056
92ROCK10.22118674
93PIK3CG0.22067457
94MAP3K30.21848392
95PRKAA10.21539650
96INSRR0.21431257
97PNCK0.20808706
98ZAP700.20674230
99CDK70.20490967
100MAPK10.19095156

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.55417743
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053215.21460952
3Primary immunodeficiency_Homo sapiens_hsa053403.32588304
4Allograft rejection_Homo sapiens_hsa053302.64674328
5Autoimmune thyroid disease_Homo sapiens_hsa053202.50333013
6Protein export_Homo sapiens_hsa030602.44718579
7Type I diabetes mellitus_Homo sapiens_hsa049402.33609368
8Measles_Homo sapiens_hsa051622.20648545
9Proteasome_Homo sapiens_hsa030502.15171379
10Base excision repair_Homo sapiens_hsa034102.14003584
11Graft-versus-host disease_Homo sapiens_hsa053322.02979439
12Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.90735037
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.90504463
14Antigen processing and presentation_Homo sapiens_hsa046121.86925426
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.85138928
16Leishmaniasis_Homo sapiens_hsa051401.80253541
17Asthma_Homo sapiens_hsa053101.77596837
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.69104528
19Rheumatoid arthritis_Homo sapiens_hsa053231.60857403
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54329067
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.54273132
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53547152
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48228991
24Osteoclast differentiation_Homo sapiens_hsa043801.39271717
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36395966
26Influenza A_Homo sapiens_hsa051641.35086447
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33505861
28Herpes simplex infection_Homo sapiens_hsa051681.32702624
29RNA polymerase_Homo sapiens_hsa030201.30685167
30Hematopoietic cell lineage_Homo sapiens_hsa046401.25533836
31Epstein-Barr virus infection_Homo sapiens_hsa051691.24560250
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.23816848
33Toxoplasmosis_Homo sapiens_hsa051451.21516183
34Tuberculosis_Homo sapiens_hsa051521.13904543
35Regulation of autophagy_Homo sapiens_hsa041401.13207211
36Systemic lupus erythematosus_Homo sapiens_hsa053221.10067202
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05239135
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04246382
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03878757
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01334519
41T cell receptor signaling pathway_Homo sapiens_hsa046600.97773645
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96668596
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96203712
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94077443
45TNF signaling pathway_Homo sapiens_hsa046680.93018889
46B cell receptor signaling pathway_Homo sapiens_hsa046620.92681766
47Staphylococcus aureus infection_Homo sapiens_hsa051500.84185781
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.82774127
49Phototransduction_Homo sapiens_hsa047440.82004045
50Non-homologous end-joining_Homo sapiens_hsa034500.76091466
51African trypanosomiasis_Homo sapiens_hsa051430.75808084
52Propanoate metabolism_Homo sapiens_hsa006400.74627533
53Legionellosis_Homo sapiens_hsa051340.73980164
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73822483
55RNA degradation_Homo sapiens_hsa030180.72011381
56Spliceosome_Homo sapiens_hsa030400.71342665
57mRNA surveillance pathway_Homo sapiens_hsa030150.69834502
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68305013
59Dorso-ventral axis formation_Homo sapiens_hsa043200.63667667
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63226264
61Hepatitis C_Homo sapiens_hsa051600.58196871
62Viral carcinogenesis_Homo sapiens_hsa052030.58026623
63Pertussis_Homo sapiens_hsa051330.57354244
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57071605
65Hepatitis B_Homo sapiens_hsa051610.55926942
66Selenocompound metabolism_Homo sapiens_hsa004500.54289706
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53800158
68Pyrimidine metabolism_Homo sapiens_hsa002400.51576044
69Alcoholism_Homo sapiens_hsa050340.50085429
70Viral myocarditis_Homo sapiens_hsa054160.49674132
71Homologous recombination_Homo sapiens_hsa034400.49598467
72Olfactory transduction_Homo sapiens_hsa047400.48009337
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46972771
74Chemokine signaling pathway_Homo sapiens_hsa040620.43965751
75Apoptosis_Homo sapiens_hsa042100.42621333
76Parkinsons disease_Homo sapiens_hsa050120.40707673
77Inositol phosphate metabolism_Homo sapiens_hsa005620.40549096
78Type II diabetes mellitus_Homo sapiens_hsa049300.39089708
79Endocytosis_Homo sapiens_hsa041440.38523902
80Fanconi anemia pathway_Homo sapiens_hsa034600.37195723
81Oxidative phosphorylation_Homo sapiens_hsa001900.36199567
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36013304
83Lysosome_Homo sapiens_hsa041420.35814650
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35751201
85Platelet activation_Homo sapiens_hsa046110.34766017
86Amphetamine addiction_Homo sapiens_hsa050310.32761209
87HTLV-I infection_Homo sapiens_hsa051660.32423920
88RNA transport_Homo sapiens_hsa030130.31211315
89Purine metabolism_Homo sapiens_hsa002300.30612855
90Calcium signaling pathway_Homo sapiens_hsa040200.30086492
91Fatty acid biosynthesis_Homo sapiens_hsa000610.28811383
92Ribosome_Homo sapiens_hsa030100.28753301
93Fructose and mannose metabolism_Homo sapiens_hsa000510.28465160
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27670867
95Circadian rhythm_Homo sapiens_hsa047100.27007960
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.26730090
97MAPK signaling pathway_Homo sapiens_hsa040100.25642556
98Butanoate metabolism_Homo sapiens_hsa006500.25509294
99Lysine degradation_Homo sapiens_hsa003100.24087799
100Insulin resistance_Homo sapiens_hsa049310.23355506

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