PLEKHA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell junction maintenance (GO:0034331)9.96230965
2neuronal action potential propagation (GO:0019227)9.21597537
3myelination in peripheral nervous system (GO:0022011)8.22414985
4peripheral nervous system axon ensheathment (GO:0032292)8.22414985
5positive regulation of developmental pigmentation (GO:0048087)7.01618631
6regulation of pigment cell differentiation (GO:0050932)6.35479013
7myelin assembly (GO:0032288)6.16771600
8cellular component maintenance (GO:0043954)6.10113786
9male sex determination (GO:0030238)6.02900718
10ensheathment of neurons (GO:0007272)5.62328585
11axon ensheathment (GO:0008366)5.62328585
12peripheral nervous system development (GO:0007422)5.18479882
13hemidesmosome assembly (GO:0031581)5.03864041
14peptidyl-tyrosine autophosphorylation (GO:0038083)4.90840669
15Leydig cell differentiation (GO:0033327)4.84319622
16endothelial cell chemotaxis (GO:0035767)4.46962187
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.42314449
18protein heterotrimerization (GO:0070208)4.31145860
19positive regulation of neurological system process (GO:0031646)4.14616621
20collagen fibril organization (GO:0030199)4.12484482
21myelination (GO:0042552)4.04963340
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.02646792
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.93606888
24basement membrane organization (GO:0071711)3.90698990
25vascular endothelial growth factor signaling pathway (GO:0038084)3.87770712
26semaphorin-plexin signaling pathway (GO:0071526)3.86540085
27cell migration involved in heart development (GO:0060973)3.84105645
28extracellular fibril organization (GO:0043206)3.82678087
29endothelial cell morphogenesis (GO:0001886)3.79019304
30cell adhesion mediated by integrin (GO:0033627)3.76145676
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73011373
32atrioventricular valve morphogenesis (GO:0003181)3.70839126
33cranial nerve structural organization (GO:0021604)3.64012944
34neurofilament cytoskeleton organization (GO:0060052)3.61966057
35dermatan sulfate metabolic process (GO:0030205)3.60078066
36negative regulation of chondrocyte differentiation (GO:0032331)3.54664915
37regulation of developmental pigmentation (GO:0048070)3.53584478
38cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.51839235
39skin development (GO:0043588)3.51153608
40collagen catabolic process (GO:0030574)3.48166589
41skin morphogenesis (GO:0043589)3.47634327
42enteric nervous system development (GO:0048484)3.41395542
43proline transport (GO:0015824)3.41257332
44tooth mineralization (GO:0034505)3.38358519
45behavioral response to pain (GO:0048266)3.38053907
46extracellular matrix assembly (GO:0085029)3.37037634
47protein retention in ER lumen (GO:0006621)3.35867990
48glial cell migration (GO:0008347)3.30103180
49collagen metabolic process (GO:0032963)3.26608929
50motile cilium assembly (GO:0044458)3.23088824
51metanephric mesenchyme development (GO:0072075)3.22459105
52cardiac myofibril assembly (GO:0055003)3.21856792
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21620227
54dermatan sulfate biosynthetic process (GO:0030208)3.19412113
55negative regulation of catenin import into nucleus (GO:0035414)3.18994323
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15293938
57Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.14411653
58kidney mesenchyme development (GO:0072074)3.13271412
59sex determination (GO:0007530)3.10907523
60adhesion of symbiont to host (GO:0044406)3.10845160
61multicellular organismal catabolic process (GO:0044243)3.07478038
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03343088
63multicellular organismal macromolecule metabolic process (GO:0044259)3.03227438
64fibril organization (GO:0097435)3.03184343
65extracellular matrix disassembly (GO:0022617)3.02489557
66adhesion of symbiont to host cell (GO:0044650)3.02386121
67virion attachment to host cell (GO:0019062)3.02386121
68myoblast migration (GO:0051451)3.00714576
69convergent extension (GO:0060026)2.99718267
70cellular response to ATP (GO:0071318)2.99227854
71regulation of establishment of planar polarity (GO:0090175)2.95827113
72retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95046952
73endodermal cell differentiation (GO:0035987)2.94287045
74vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93702397
75glomerular basement membrane development (GO:0032836)2.90213193
76mesenchymal-epithelial cell signaling (GO:0060638)2.89529175
77adherens junction assembly (GO:0034333)2.89071156
78type B pancreatic cell proliferation (GO:0044342)2.88798403
79chondrocyte proliferation (GO:0035988)2.88027522
80chondroitin sulfate catabolic process (GO:0030207)2.87310030
81urinary tract smooth muscle contraction (GO:0014848)2.86102482
82regulation of glucose import in response to insulin stimulus (GO:2001273)2.85355131
83cell-substrate junction assembly (GO:0007044)2.83738218
84cochlea morphogenesis (GO:0090103)2.82803398
85epithelial cell-cell adhesion (GO:0090136)2.81866132
86wound healing, spreading of epidermal cells (GO:0035313)2.81809238
87multicellular organismal metabolic process (GO:0044236)2.81163855
88regulation of p38MAPK cascade (GO:1900744)2.80304203
89regulation of extracellular matrix disassembly (GO:0010715)2.79559662
90keratan sulfate catabolic process (GO:0042340)2.79551612
91detection of temperature stimulus (GO:0016048)2.77953204
92muscle cell migration (GO:0014812)2.77915120
93positive regulation of receptor recycling (GO:0001921)2.76793946
94branching involved in salivary gland morphogenesis (GO:0060445)2.75066383
95mitotic cell cycle arrest (GO:0071850)2.74985062
96sequestering of extracellular ligand from receptor (GO:0035581)2.73820272
97venous blood vessel morphogenesis (GO:0048845)2.73637386
98negative regulation of cartilage development (GO:0061037)2.73220653
99positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73115157
100cell migration involved in sprouting angiogenesis (GO:0002042)2.71268620
101regulation of plasminogen activation (GO:0010755)2.70022586
102negative regulation of smooth muscle cell migration (GO:0014912)2.69583683
103regulation of skeletal muscle contraction (GO:0014819)2.69479114
104anatomical structure arrangement (GO:0048532)2.68592869
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.68566298
106axon extension involved in axon guidance (GO:0048846)2.68566298
107positive regulation of Rho protein signal transduction (GO:0035025)2.68288596
108regulation of apoptotic cell clearance (GO:2000425)2.67788220
109lung vasculature development (GO:0060426)2.66009227
110negative regulation of fatty acid transport (GO:2000192)2.65308615
111signal complex assembly (GO:0007172)2.65009186
112cell migration in hindbrain (GO:0021535)2.64933454
113focal adhesion assembly (GO:0048041)2.64345153
114cell-substrate adherens junction assembly (GO:0007045)2.64345153
115negative regulation of osteoblast proliferation (GO:0033689)2.63909693
116regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62829747
117paraxial mesoderm development (GO:0048339)2.62616663
118regulation of axon extension involved in axon guidance (GO:0048841)2.61974386
119negative regulation of protein localization to cell surface (GO:2000009)2.58742510
120regulation of integrin-mediated signaling pathway (GO:2001044)2.58598575
121establishment of apical/basal cell polarity (GO:0035089)2.57223740
122regulation of response to osmotic stress (GO:0047484)2.56820072
123neural tube development (GO:0021915)2.55630501
124stress fiber assembly (GO:0043149)2.54821128
125regulation of endothelial cell chemotaxis (GO:2001026)2.54735961
126regulation of cardiac muscle hypertrophy (GO:0010611)2.54627769
127response to prostaglandin E (GO:0034695)2.54159776
128myelin maintenance (GO:0043217)2.53759259
129neuronal action potential (GO:0019228)2.52991598
130fucose catabolic process (GO:0019317)2.52555667
131L-fucose metabolic process (GO:0042354)2.52555667
132L-fucose catabolic process (GO:0042355)2.52555667
133barbed-end actin filament capping (GO:0051016)2.51880752
134myofibril assembly (GO:0030239)2.51705034
135endocytic recycling (GO:0032456)2.51487489
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.50637780
137non-canonical Wnt signaling pathway (GO:0035567)2.49980466
138negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.49880800
139regulation of histone phosphorylation (GO:0033127)2.49821533
140negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.49460622
141endocardial cushion morphogenesis (GO:0003203)2.48245916
142positive regulation of p38MAPK cascade (GO:1900745)2.48173537
143glycosaminoglycan catabolic process (GO:0006027)2.47260536
144cardiac muscle tissue development (GO:0048738)2.46975471
145ganglion development (GO:0061548)2.46062120
146regulation of muscle hypertrophy (GO:0014743)2.45801417
147interleukin-6-mediated signaling pathway (GO:0070102)2.44609200
148growth hormone receptor signaling pathway (GO:0060396)2.44347331
149auditory receptor cell stereocilium organization (GO:0060088)2.44231919
150blood vessel development (GO:0001568)2.43528004
151bone trabecula formation (GO:0060346)2.43335251
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.42325010
153regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42223631
154regulation of heat generation (GO:0031650)2.39545443
155glycine transport (GO:0015816)2.39441609
156extracellular structure organization (GO:0043062)2.39234469
157extracellular matrix organization (GO:0030198)2.39043194
158response to follicle-stimulating hormone (GO:0032354)2.38510791
159phagocytosis, engulfment (GO:0006911)2.37135157
160calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35272775
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.34100769
162cell-matrix adhesion (GO:0007160)2.33333143
163regulation of myelination (GO:0031641)2.31966703
164inner ear receptor stereocilium organization (GO:0060122)2.31803796
165proline biosynthetic process (GO:0006561)2.31123068
166definitive hemopoiesis (GO:0060216)2.30353967
167purinergic nucleotide receptor signaling pathway (GO:0035590)2.29934575
168regulation of protein polyubiquitination (GO:1902914)2.28354230
169sympathetic nervous system development (GO:0048485)2.28276026
170substrate adhesion-dependent cell spreading (GO:0034446)2.28129351
171positive regulation of cellular amide metabolic process (GO:0034250)2.27548488
172positive regulation of smooth muscle cell migration (GO:0014911)2.26033915
173response to pain (GO:0048265)2.23215301
174notochord development (GO:0030903)2.21848703
175negative regulation of JUN kinase activity (GO:0043508)2.21683090
176muscle cell cellular homeostasis (GO:0046716)2.21319188
177extracellular negative regulation of signal transduction (GO:1900116)2.21268416
178extracellular regulation of signal transduction (GO:1900115)2.21268416
179detection of mechanical stimulus involved in sensory perception (GO:0050974)2.21093250
180bundle of His cell to Purkinje myocyte communication (GO:0086069)2.15526785
181cell-cell junction maintenance (GO:0045217)12.8865631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.55764780
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.13448394
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03935474
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95011553
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92810451
6GBX2_23144817_ChIP-Seq_PC3_Human2.89909139
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.65521084
8LXR_22292898_ChIP-Seq_THP-1_Human2.47717361
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.42408409
10ZNF263_19887448_ChIP-Seq_K562_Human2.40732334
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.28621730
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20015317
13CLOCK_20551151_ChIP-Seq_293T_Human2.14885304
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12508079
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12356450
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02830307
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.97989624
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91842068
19RACK7_27058665_Chip-Seq_MCF-7_Human1.91287820
20AHR_22903824_ChIP-Seq_MCF-7_Human1.90860088
21NFIB_24661679_ChIP-Seq_LUNG_Mouse1.87630842
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83658902
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83566665
24* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.81498322
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78566122
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78566122
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78566122
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75383622
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.74119744
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72108058
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69935387
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69905732
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.69726221
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68415707
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.68258990
36* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68094873
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64101695
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63152989
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60576854
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59133680
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57223133
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55804457
43SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.54626737
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53000124
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49566333
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.48265022
47TP53_22127205_ChIP-Seq_IMR90_Human1.47228186
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.46867157
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.46867157
50* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44528187
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43007945
52STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40117088
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.39637053
54* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38913796
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37449046
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36359069
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35440060
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35440060
59CTCF_27219007_Chip-Seq_Bcells_Human1.35060401
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.35033388
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33194104
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30934686
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30800980
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.30457072
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30409670
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.30334088
67TP53_16413492_ChIP-PET_HCT116_Human1.30124265
68SMAD4_21799915_ChIP-Seq_A2780_Human1.29189807
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28773147
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.27366875
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27300381
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27023632
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26367394
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26216191
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.25066105
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24973087
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24226194
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24023956
79CJUN_26792858_Chip-Seq_BT549_Human1.22882937
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22666251
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22198030
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22157203
83STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21434849
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19364174
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19202724
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.18998054
87STAT3_23295773_ChIP-Seq_U87_Human1.17534768
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17010060
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16816375
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16205406
91GATA1_22025678_ChIP-Seq_K562_Human1.15821455
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15491589
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15281079
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.13827559
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13460385
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12693935
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12248045
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11326233
99KDM2B_26808549_Chip-Seq_DND41_Human1.11163566
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11041850
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10375549
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09735116
103SA1_22415368_ChIP-Seq_MEFs_Mouse1.09534223
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09453391
105* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09274145
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.09153915
107SMC4_20622854_ChIP-Seq_HELA_Human1.09146459
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08786046
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08598664
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08213306
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07563442
112ATF3_27146783_Chip-Seq_COLON_Human1.07302291
113DROSHA_22980978_ChIP-Seq_HELA_Human1.07010274
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06811410
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06697767
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06425180
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.06264811
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06249319
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05953905
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05803547
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05316321
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04942497
123AR_21572438_ChIP-Seq_LNCaP_Human1.04843124
124TCF4_18268006_ChIP-ChIP_LS174T_Human1.04684320
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03918367
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.03841094
127KDM2B_26808549_Chip-Seq_K562_Human1.03427192
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03220769
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.03213936
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02615269
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02594440
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01244975
133RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01166831
134SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01005694
135TP63_22573176_ChIP-Seq_HFKS_Human1.00954418
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00871672
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99481684
138TBL1_22424771_ChIP-Seq_293T_Human0.99339825
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98942908
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98917938
141AR_19668381_ChIP-Seq_PC3_Human0.98793152
142TCF4_23295773_ChIP-Seq_U87_Human0.98789561
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.98760122
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98113322
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97712022
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97383122
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97024617
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.96472829
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96282688
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.93608813
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93323996
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93037774
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92657087
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.92255111
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.91998367
156P300_19829295_ChIP-Seq_ESCs_Human0.91601574
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.91307792
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.90312856
159SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90304936
160ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90223781
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89699627
162KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89677858
163JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89638523
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.89414840
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.89353154
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89209224
167SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89060930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.69664600
2MP0004272_abnormal_basement_membrane5.36951760
3MP0008438_abnormal_cutaneous_collagen4.75226292
4MP0001968_abnormal_touch/_nociception4.59618658
5MP0008260_abnormal_autophagy4.44876553
6MP0003705_abnormal_hypodermis_morpholog4.19445806
7MP0003045_fibrosis3.60845007
8MP0000920_abnormal_myelination3.59929977
9MP0005171_absent_coat_pigmentation3.18901963
10MP0005275_abnormal_skin_tensile3.07569283
11MP0004858_abnormal_nervous_system3.00295039
12MP0000749_muscle_degeneration2.99465637
13MP0005503_abnormal_tendon_morphology2.94828539
14MP0000751_myopathy2.93195573
15MP0009384_cardiac_valve_regurgitation2.54220339
16MP0002736_abnormal_nociception_after2.53013863
17MP0003634_abnormal_glial_cell2.52797668
18MP0002734_abnormal_mechanical_nocicepti2.50173288
19MP0002735_abnormal_chemical_nociception2.35009321
20MP0010368_abnormal_lymphatic_system2.27702311
21MP0005623_abnormal_meninges_morphology2.18779551
22MP0000747_muscle_weakness2.15179404
23MP0003315_abnormal_perineum_morphology2.08241377
24MP0002733_abnormal_thermal_nociception2.07903969
25MP0001661_extended_life_span2.07558550
26MP0004145_abnormal_muscle_electrophysio2.06386982
27MP0002108_abnormal_muscle_morphology2.01058351
28MP0004381_abnormal_hair_follicle1.90358442
29MP0002938_white_spotting1.89441573
30MP0001849_ear_inflammation1.79460008
31MP0002249_abnormal_larynx_morphology1.69869202
32MP0002272_abnormal_nervous_system1.67662182
33MP0005670_abnormal_white_adipose1.61644896
34MP0005023_abnormal_wound_healing1.59830983
35MP0000750_abnormal_muscle_regeneration1.54360058
36MP0002067_abnormal_sensory_capabilities1.54157119
37MP0002751_abnormal_autonomic_nervous1.51349671
38MP0001970_abnormal_pain_threshold1.51183061
39MP0003950_abnormal_plasma_membrane1.50022285
40MP0004084_abnormal_cardiac_muscle1.49782315
41MP0006054_spinal_hemorrhage1.47866570
42MP0001542_abnormal_bone_strength1.45414718
43MP0005409_darkened_coat_color1.42349773
44MP0003091_abnormal_cell_migration1.41673745
45MP0002295_abnormal_pulmonary_circulatio1.41416476
46MP0002896_abnormal_bone_mineralization1.39823580
47MP0002168_other_aberrant_phenotype1.39638636
48MP0001986_abnormal_taste_sensitivity1.37733939
49MP0004134_abnormal_chest_morphology1.35533547
50MP0005075_abnormal_melanosome_morpholog1.29321621
51MP0005595_abnormal_vascular_smooth1.24410169
52MP0000013_abnormal_adipose_tissue1.21505713
53MP0009250_abnormal_appendicular_skeleto1.19363410
54MP0003283_abnormal_digestive_organ1.19176218
55MP0006138_congestive_heart_failure1.11383050
56MP0005058_abnormal_lysosome_morphology1.11292175
57MP0002933_joint_inflammation1.11154020
58MP0003632_abnormal_nervous_system1.11077143
59MP0002877_abnormal_melanocyte_morpholog1.10930317
60MP0000678_abnormal_parathyroid_gland1.07619830
61MP0000428_abnormal_craniofacial_morphol1.07403110
62MP0003942_abnormal_urinary_system1.07209432
63MP0005508_abnormal_skeleton_morphology1.03791407
64MP0000759_abnormal_skeletal_muscle1.03693156
65MP0009780_abnormal_chondrocyte_physiolo1.01026451
66MP0002932_abnormal_joint_morphology1.01021423
67MP0002060_abnormal_skin_morphology1.00531931
68MP0009379_abnormal_foot_pigmentation1.00403188
69MP0003631_nervous_system_phenotype0.99580266
70MP0001879_abnormal_lymphatic_vessel0.99084081
71MP0004233_abnormal_muscle_weight0.98504065
72MP0004087_abnormal_muscle_fiber0.98183411
73MP0004036_abnormal_muscle_relaxation0.97344920
74MP0005076_abnormal_cell_differentiation0.96974066
75MP0000534_abnormal_ureter_morphology0.96817689
76MP0005330_cardiomyopathy0.96446884
77MP0000049_abnormal_middle_ear0.96313299
78MP0009840_abnormal_foam_cell0.96105125
79MP0001188_hyperpigmentation0.96033697
80MP0000163_abnormal_cartilage_morphology0.94924408
81MP0010771_integument_phenotype0.91844617
82MP0005390_skeleton_phenotype0.89208396
83MP0001958_emphysema0.88131385
84MP0000462_abnormal_digestive_system0.87957541
85MP0001299_abnormal_eye_distance/0.87671870
86MP0002254_reproductive_system_inflammat0.87071027
87MP0003115_abnormal_respiratory_system0.86064660
88MP0002269_muscular_atrophy0.85803512
89MP0005369_muscle_phenotype0.85260576
90MP0005408_hypopigmentation0.84843799
91MP0003566_abnormal_cell_adhesion0.84507768
92MP0005257_abnormal_intraocular_pressure0.83577813
93MP0000432_abnormal_head_morphology0.83461659
94MP0000613_abnormal_salivary_gland0.82710928
95MP0002115_abnormal_skeleton_extremities0.81876166
96MP0002128_abnormal_blood_circulation0.81355371
97MP0002106_abnormal_muscle_physiology0.81349486
98MP0002095_abnormal_skin_pigmentation0.78677044
99MP0003633_abnormal_nervous_system0.78167522
100MP0001614_abnormal_blood_vessel0.77924907
101MP0008569_lethality_at_weaning0.77733603
102MP0000467_abnormal_esophagus_morphology0.76932009
103MP0002089_abnormal_postnatal_growth/wei0.75698628
104MP0009053_abnormal_anal_canal0.75493200
105MP0005620_abnormal_muscle_contractility0.75294492
106MP0009046_muscle_twitch0.74650990
107MP0004510_myositis0.74475000
108MP0005248_abnormal_Harderian_gland0.74398728
109MP0001186_pigmentation_phenotype0.73969938
110MP0004270_analgesia0.73715252
111MP0010630_abnormal_cardiac_muscle0.73290213
112MP0001243_abnormal_dermal_layer0.73054701
113MP0005645_abnormal_hypothalamus_physiol0.72032359
114MP0003453_abnormal_keratinocyte_physiol0.70034320
115MP0003941_abnormal_skin_development0.69098679
116MP0002113_abnormal_skeleton_development0.68670301
117MP0005377_hearing/vestibular/ear_phenot0.68551797
118MP0003878_abnormal_ear_physiology0.68551797
119MP0002998_abnormal_bone_remodeling0.68501793
120MP0000762_abnormal_tongue_morphology0.68451376
121MP0010386_abnormal_urinary_bladder0.67928132
122MP0002697_abnormal_eye_size0.67823278
123MP0001270_distended_abdomen0.67506779
124MP0002114_abnormal_axial_skeleton0.67230701
125MP0002282_abnormal_trachea_morphology0.66765797
126MP0003279_aneurysm0.66418243
127MP0001915_intracranial_hemorrhage0.64196057
128MP0002075_abnormal_coat/hair_pigmentati0.63222971
129MP0005375_adipose_tissue_phenotype0.63201646
130MP0001346_abnormal_lacrimal_gland0.63069064
131MP0003385_abnormal_body_wall0.62969491
132MP0005197_abnormal_uvea_morphology0.62903053
133MP0001348_abnormal_lacrimal_gland0.62408926
134MP0002184_abnormal_innervation0.61516735
135MP0002925_abnormal_cardiovascular_devel0.59983593
136MP0003755_abnormal_palate_morphology0.56869128
137MP0000733_abnormal_muscle_development0.56721955
138MP0000516_abnormal_urinary_system0.55934859
139MP0005367_renal/urinary_system_phenotyp0.55934859
140MP0002109_abnormal_limb_morphology0.53533231
141MP0002163_abnormal_gland_morphology0.52713415
142MP0002127_abnormal_cardiovascular_syste0.52369376
143MP0008932_abnormal_embryonic_tissue0.50164714
144MP0010030_abnormal_orbit_morphology0.50057073
145MP0005395_other_phenotype0.48978531
146MP0000778_abnormal_nervous_system0.48609169
147MP0000579_abnormal_nail_morphology0.48190295
148MP0004811_abnormal_neuron_physiology0.47103411
149MP0006276_abnormal_autonomic_nervous0.45363961
150MP0000003_abnormal_adipose_tissue0.44455804
151MP0009278_abnormal_bone_marrow0.44074318
152MP0003183_abnormal_peptide_metabolism0.41538679
153MP0002229_neurodegeneration0.41503397
154MP0001963_abnormal_hearing_physiology0.41001328
155MP0002116_abnormal_craniofacial_bone0.40860548
156MP0002160_abnormal_reproductive_system0.38273239
157MP0010352_gastrointestinal_tract_polyps0.38116676
158MP0008004_abnormal_stomach_pH0.37783054
159MP0000767_abnormal_smooth_muscle0.37314005

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)7.93220138
2Increased CSF protein (HP:0002922)7.35960249
3Upper limb muscle weakness (HP:0003484)7.28866228
4Steppage gait (HP:0003376)6.27277034
5Onion bulb formation (HP:0003383)6.09682930
6Peripheral hypomyelination (HP:0007182)5.99502710
7Decreased number of peripheral myelinated nerve fibers (HP:0003380)5.56778616
8Foot dorsiflexor weakness (HP:0009027)5.26432354
9Hammertoe (HP:0001765)5.23733869
10Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.14310775
11Decreased motor nerve conduction velocity (HP:0003431)4.93636972
12Peripheral demyelination (HP:0011096)4.90214725
13Abnormality of the foot musculature (HP:0001436)4.85353019
14Abnormality of the vocal cords (HP:0008777)4.79176904
15Abnormal pupillary function (HP:0007686)4.75516354
16Postural tremor (HP:0002174)4.55237448
17Shallow orbits (HP:0000586)4.12309094
18Progressive sensorineural hearing impairment (HP:0000408)4.07692570
19Broad metatarsal (HP:0001783)3.82437302
20Aortic aneurysm (HP:0004942)3.66031136
21Cervical subluxation (HP:0003308)3.31317533
22Obstructive sleep apnea (HP:0002870)3.22012454
23Vascular tortuosity (HP:0004948)3.17786376
24Increased variability in muscle fiber diameter (HP:0003557)3.10132814
25Abnormal sex determination (HP:0012244)2.91194350
26Sex reversal (HP:0012245)2.91194350
27Round ear (HP:0100830)2.86564062
28Progressive hearing impairment (HP:0001730)2.83971224
29Biconcave vertebral bodies (HP:0004586)2.81439128
30Atrophic scars (HP:0001075)2.78965658
31Mitral regurgitation (HP:0001653)2.75615052
32Arterial tortuosity (HP:0005116)2.71951755
33Wormian bones (HP:0002645)2.71038645
34Abnormality of calcium-phosphate metabolism (HP:0100530)2.66218746
35Hypoplasia of the iris (HP:0007676)2.64926417
36Blue sclerae (HP:0000592)2.64380544
37Distal sensory impairment (HP:0002936)2.62289804
38Abnormality of skeletal muscle fiber size (HP:0012084)2.58423053
39Upper limb amyotrophy (HP:0009129)2.56790014
40Distal upper limb amyotrophy (HP:0007149)2.56790014
41Vertebral compression fractures (HP:0002953)2.53554279
42Hyperacusis (HP:0010780)2.50136166
43Aortic regurgitation (HP:0001659)2.48899318
44Ulnar bowing (HP:0003031)2.44853742
45Hypoplasia of the uterus (HP:0000013)2.38026606
46Turricephaly (HP:0000262)2.36883413
47Fragile skin (HP:0001030)2.33539258
48Ectopia lentis (HP:0001083)2.33102967
49Hypomagnesemia (HP:0002917)2.32595646
50Thin ribs (HP:0000883)2.29101992
51Joint stiffness (HP:0001387)2.28424355
52Wide anterior fontanel (HP:0000260)2.26929396
53Renal duplication (HP:0000075)2.26866155
54Premature rupture of membranes (HP:0001788)2.24226597
55Alopecia of scalp (HP:0002293)2.23088491
56Joint laxity (HP:0001388)2.22735825
57Aortic valve stenosis (HP:0001650)2.22723293
58Kyphoscoliosis (HP:0002751)2.21521339
59Thin bony cortex (HP:0002753)2.20985851
60Natal tooth (HP:0000695)2.18562416
61Aneurysm (HP:0002617)2.16773299
62Bell-shaped thorax (HP:0001591)2.10066986
63Flat cornea (HP:0007720)2.08947858
64Hip contracture (HP:0003273)2.08285520
65Abnormality of complement system (HP:0005339)2.06290285
66Complement deficiency (HP:0004431)2.04269493
67Elbow flexion contracture (HP:0002987)2.02934336
68Infantile muscular hypotonia (HP:0008947)2.01516256
69Ulnar claw (HP:0001178)16.5279520
70Segmental peripheral demyelination/remyelination (HP:0003481)13.5728780
71Impaired proprioception (HP:0010831)10.6696283
72Termporal pattern (HP:0011008)10.2581184
73Insidious onset (HP:0003587)10.2581184
74J-shaped sella turcica (HP:0002680)1.99835715
75Nonimmune hydrops fetalis (HP:0001790)1.96548534
76Abnormality of magnesium homeostasis (HP:0004921)1.96346174
77Venous insufficiency (HP:0005293)1.95761504
78Systemic lupus erythematosus (HP:0002725)1.94982856
79Hand muscle atrophy (HP:0009130)1.93737072
80Abnormality of the acetabulum (HP:0003170)1.91849357
81Venous abnormality (HP:0002624)1.89923432
82Ulnar deviation of the wrist (HP:0003049)1.89016883
83Disproportionate tall stature (HP:0001519)1.88818271
84Hypoplastic ischia (HP:0003175)1.88157863
85Pulmonary artery stenosis (HP:0004415)1.86826924
86Stridor (HP:0010307)1.85271721
87Abnormal delivery (HP:0001787)1.84180539
88Bronchomalacia (HP:0002780)1.83309528
89Coxa vara (HP:0002812)1.82384918
90Mitral stenosis (HP:0001718)1.81658835
91Lymphangioma (HP:0100764)1.79996479
92Generalized amyotrophy (HP:0003700)1.79468588
93Coronal craniosynostosis (HP:0004440)1.78100526
94Peritonitis (HP:0002586)1.78055911
95Achilles tendon contracture (HP:0001771)1.76741981
96Long toe (HP:0010511)1.76559935
97Aplasia/hypoplasia of the uterus (HP:0008684)1.76154379
98White forelock (HP:0002211)1.74797646
99Abnormality of the ischium (HP:0003174)1.74275737
100Vertebral arch anomaly (HP:0008438)1.72458595
101Abnormality of the pupil (HP:0000615)1.72245020
102Deformed tarsal bones (HP:0008119)1.72188886
103Protruding ear (HP:0000411)1.70954070
104Breech presentation (HP:0001623)1.70764834
105Ankle contracture (HP:0006466)1.70670989
106Atelectasis (HP:0100750)1.70647145
107Advanced eruption of teeth (HP:0006288)1.70132490
108Calcaneovalgus deformity (HP:0001848)1.69130396
109Bladder diverticulum (HP:0000015)1.61914529
110Difficulty walking (HP:0002355)1.61516782
111Abnormal auditory evoked potentials (HP:0006958)1.54597523
112Submucous cleft hard palate (HP:0000176)1.52298430
113Protrusio acetabuli (HP:0003179)1.48067796
114Cerebral aneurysm (HP:0004944)1.46948659
115Soft skin (HP:0000977)1.45822923
116Aplasia cutis congenita (HP:0001057)1.40338367
117Germ cell neoplasia (HP:0100728)1.39053194
118Aortic dissection (HP:0002647)1.31825435
119Renovascular hypertension (HP:0100817)1.29413041
120Hypercalciuria (HP:0002150)1.24848415
121Slow progression (HP:0003677)1.21679464
122Alacrima (HP:0000522)1.15752447
123Pes cavus (HP:0001761)1.14955338
124Mildly elevated creatine phosphokinase (HP:0008180)1.09457623
125Increased connective tissue (HP:0009025)1.09318397
126Follicular hyperkeratosis (HP:0007502)1.09118294
127Childhood onset (HP:0011463)1.08756022
128Dilatation of the ascending aorta (HP:0005111)1.08346969
129Muscle fiber splitting (HP:0003555)1.06762958
130Neonatal short-limb short stature (HP:0008921)1.05548498
131Abnormality of male internal genitalia (HP:0000022)1.04443709
132Increased corneal curvature (HP:0100692)1.04324921
133Keratoconus (HP:0000563)1.04324921
134Overgrowth (HP:0001548)1.04184718
135Muscular dystrophy (HP:0003560)1.03088750
136Type 1 muscle fiber predominance (HP:0003803)1.00519341
137Wrist flexion contracture (HP:0001239)0.99923293
138Spinal rigidity (HP:0003306)0.99068401
139Mitral valve prolapse (HP:0001634)0.97862706
140Hypoventilation (HP:0002791)0.96108194
141Hypercortisolism (HP:0001578)0.95835427
142Narrow nasal bridge (HP:0000446)0.94946271
143Juvenile onset (HP:0003621)0.93793380
144Dysautonomia (HP:0002459)0.92941730
145Genu recurvatum (HP:0002816)0.92235349
146Muscle fibrillation (HP:0010546)0.92112671
147Bowel diverticulosis (HP:0005222)0.91735281
148Osteolytic defects of the phalanges of the hand (HP:0009771)0.91692580
149Osteolytic defects of the hand bones (HP:0009699)0.91692580
150Decreased lacrimation (HP:0000633)0.90653656
151Gonadal dysgenesis (HP:0000133)0.90649065
152Hyperextensible skin (HP:0000974)0.88469264
153Heterogeneous (HP:0001425)0.84837701
154Pterygium (HP:0001059)0.84501772
155Gait ataxia (HP:0002066)0.84170192
156Premature loss of primary teeth (HP:0006323)0.84003147
157Mask-like facies (HP:0000298)0.83510132
158Neoplasm of the oral cavity (HP:0100649)0.83042993
159Limited hip movement (HP:0008800)0.82319900
160Gastrointestinal atresia (HP:0002589)0.81488534
161Distal lower limb muscle weakness (HP:0009053)0.81338389
162Variable expressivity (HP:0003828)0.80208937
163Milia (HP:0001056)0.80172955
164Mild short stature (HP:0003502)0.79467420
165Slender build (HP:0001533)0.78616860
166Esophageal atresia (HP:0002032)0.76105431
167Ectropion (HP:0000656)0.75074361
168Difficulty climbing stairs (HP:0003551)0.74597957
169Abnormality of dentin (HP:0010299)0.73999257
170Striae distensae (HP:0001065)0.73232194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK24.31614754
2IRAK14.17543964
3RIPK13.51383698
4TRIB33.47142350
5AKT33.15645409
6DDR23.03835771
7MYLK2.73023683
8CASK2.65106486
9ICK2.50171511
10ZAK2.34066853
11LMTK22.29122391
12MAP3K62.26231507
13EPHB12.24283902
14YES12.20990238
15ERN12.18769592
16PINK12.17004780
17RET2.07254157
18FGFR42.05310306
19INSRR2.02744378
20MST1R1.98045347
21PRKD21.88919752
22BMX1.85021300
23LATS21.83551004
24PHKG11.81432321
25PHKG21.81432321
26PRKD31.79749094
27EPHA31.78778137
28PKN21.62954401
29MAPK151.62631567
30MATK1.61448415
31UHMK11.61275298
32PAK41.59542827
33DMPK1.58726700
34WNK41.58350287
35MARK31.56916651
36WNK11.56044752
37KSR21.47989271
38MARK21.47141521
39CDC42BPA1.44987160
40LATS11.41162109
41MAP3K21.38532026
42MUSK1.37145270
43TRPM71.29562565
44NTRK31.29431729
45SMG11.26712444
46NTRK11.26707818
47PDGFRB1.25573058
48MET1.24360737
49PIM21.23360690
50PAK21.21015016
51TESK11.19885497
52PLK21.19187759
53SIK11.17960625
54EEF2K1.14517261
55STK391.10702586
56PDGFRA1.08637906
57STK381.06763785
58ERBB21.05649542
59STK38L1.04916882
60NEK91.02129161
61FRK1.01749015
62TGFBR21.01311163
63MAP3K70.98269662
64ERBB40.96142707
65MOS0.95807356
66RPS6KA60.95533292
67RPS6KA20.93494614
68MAP3K30.92865047
69CDK120.91636465
70PTK20.91440279
71SIK30.91389417
72PTK2B0.90253468
73CAMK1D0.89799163
74PIM10.88168565
75PIK3CG0.87884472
76MAPK70.86124859
77PTK60.86080862
78GSK3A0.86036020
79ROCK20.85582858
80FER0.85032118
81OBSCN0.84444292
82RPS6KC10.83869375
83RPS6KL10.83869375
84PRKD10.82913136
85RIPK40.81855349
86TIE10.81821654
87FGR0.81274979
88ERBB30.80644648
89ABL20.79794123
90JAK10.78088405
91JAK30.73480630
92TTN0.68869955
93LIMK10.68306587
94STK240.67682153
95EPHA20.67334421
96TYRO30.67212055
97PRKAA10.65279723
98STK30.64634379
99MAPKAPK30.64573463
100PRKG20.64220046
101MAPK130.64180206
102CSK0.62843794
103FLT30.61594260
104TAOK20.60869998
105NME20.58913639
106ILK0.58538892
107MAP3K140.54886915
108ARAF0.54523946
109PDK30.54482065
110PDK40.54482065
111HIPK20.52919724
112CHUK0.51773962
113PRKCI0.51674387
114IRAK30.51166763
115FGFR10.50974424
116SGK2230.50704290
117SGK4940.50704290
118PDK20.50180192
119DYRK1B0.48534572
120PRKCE0.48077371
121MAP2K10.47959328
122CDK70.45282660
123DAPK30.45071076
124CAMK1G0.44144697
125SGK20.43960394
126ROCK10.43255273
127BMPR20.42185707
128SRPK10.41129055
129CHEK20.40651397
130PRKAA20.40540419
131CAMK2G0.40436202
132KIT0.39241026
133ADRBK10.39060094
134ADRBK20.38905074
135EIF2AK20.38710547
136MAP3K10.36765867
137EPHB20.36555360
138NME10.36508528
139PAK10.36167437
140MTOR0.35894964
141PRPF4B0.35457314
142MAPK10.35368032
143MAPK40.35323556
144CSNK1A10.35311550
145TBK10.34640814
146DYRK30.34451322
147PRKCH0.34130521
148RPS6KA10.33898000
149RPS6KB10.33051142
150FGFR30.32568295
151CLK10.31820791
152MAPKAPK20.31662927
153JAK20.31124163
154PKN10.29813627
155MAPK80.29224791
156CDK190.27656014

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.52988300
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.50281597
3Dorso-ventral axis formation_Homo sapiens_hsa043202.46947677
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.41198909
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.23128193
6Complement and coagulation cascades_Homo sapiens_hsa046102.19823155
7Protein digestion and absorption_Homo sapiens_hsa049742.07124115
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.03893373
9Focal adhesion_Homo sapiens_hsa045101.98750702
10Small cell lung cancer_Homo sapiens_hsa052221.97999345
11Dilated cardiomyopathy_Homo sapiens_hsa054141.94587673
12Viral myocarditis_Homo sapiens_hsa054161.92150614
13Amoebiasis_Homo sapiens_hsa051461.92069794
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.89972944
15Thyroid cancer_Homo sapiens_hsa052161.75418920
16Hedgehog signaling pathway_Homo sapiens_hsa043401.60469012
17Other glycan degradation_Homo sapiens_hsa005111.56853598
18Axon guidance_Homo sapiens_hsa043601.56599834
19ErbB signaling pathway_Homo sapiens_hsa040121.52692206
20Toxoplasmosis_Homo sapiens_hsa051451.49788726
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47850845
22Endometrial cancer_Homo sapiens_hsa052131.47424485
23Basal cell carcinoma_Homo sapiens_hsa052171.46515193
24Melanoma_Homo sapiens_hsa052181.44066896
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38065571
26Lysine degradation_Homo sapiens_hsa003101.36298478
27Glioma_Homo sapiens_hsa052141.34893123
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32995560
29African trypanosomiasis_Homo sapiens_hsa051431.31611626
30Tight junction_Homo sapiens_hsa045301.29466991
31Prolactin signaling pathway_Homo sapiens_hsa049171.28441146
32Adherens junction_Homo sapiens_hsa045201.22396449
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20446588
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19533611
35Chronic myeloid leukemia_Homo sapiens_hsa052201.11311122
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10502664
37Salmonella infection_Homo sapiens_hsa051321.08884285
38MicroRNAs in cancer_Homo sapiens_hsa052061.08175763
39Phagosome_Homo sapiens_hsa041451.05896150
40PPAR signaling pathway_Homo sapiens_hsa033201.03722318
41Tyrosine metabolism_Homo sapiens_hsa003501.01342738
42Phenylalanine metabolism_Homo sapiens_hsa003600.98777549
43Estrogen signaling pathway_Homo sapiens_hsa049150.98306002
44Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98296127
45Circadian rhythm_Homo sapiens_hsa047100.96431403
46Prostate cancer_Homo sapiens_hsa052150.95753892
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.93401077
48Bile secretion_Homo sapiens_hsa049760.92296897
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92191434
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.91775225
51Hepatitis C_Homo sapiens_hsa051600.91124871
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90685677
53Bladder cancer_Homo sapiens_hsa052190.89909416
54TGF-beta signaling pathway_Homo sapiens_hsa043500.89194632
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88915756
56Taste transduction_Homo sapiens_hsa047420.87900199
57Pathways in cancer_Homo sapiens_hsa052000.86475809
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85763976
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82505133
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82024047
61Hippo signaling pathway_Homo sapiens_hsa043900.81918780
62Proteoglycans in cancer_Homo sapiens_hsa052050.79875528
63Rheumatoid arthritis_Homo sapiens_hsa053230.78273069
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78195566
65Acute myeloid leukemia_Homo sapiens_hsa052210.77058007
66Insulin signaling pathway_Homo sapiens_hsa049100.76272093
67Malaria_Homo sapiens_hsa051440.75884167
68Synaptic vesicle cycle_Homo sapiens_hsa047210.75213102
69Ras signaling pathway_Homo sapiens_hsa040140.74879568
70Collecting duct acid secretion_Homo sapiens_hsa049660.73812931
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72493815
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72477821
73Insulin secretion_Homo sapiens_hsa049110.72355372
74Shigellosis_Homo sapiens_hsa051310.72271810
75Histidine metabolism_Homo sapiens_hsa003400.72165129
76MAPK signaling pathway_Homo sapiens_hsa040100.71561785
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.71163992
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.71037617
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70141988
80Wnt signaling pathway_Homo sapiens_hsa043100.69777147
81Long-term depression_Homo sapiens_hsa047300.69511462
82Gap junction_Homo sapiens_hsa045400.69384884
83Prion diseases_Homo sapiens_hsa050200.69301226
84Arginine biosynthesis_Homo sapiens_hsa002200.68331721
85Apoptosis_Homo sapiens_hsa042100.68221615
86Pancreatic cancer_Homo sapiens_hsa052120.66536409
87Chemokine signaling pathway_Homo sapiens_hsa040620.66191286
88GnRH signaling pathway_Homo sapiens_hsa049120.65497285
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65281516
90AMPK signaling pathway_Homo sapiens_hsa041520.65121010
91Sulfur relay system_Homo sapiens_hsa041220.64264053
92Notch signaling pathway_Homo sapiens_hsa043300.64233005
93Fructose and mannose metabolism_Homo sapiens_hsa000510.63979069
94Pertussis_Homo sapiens_hsa051330.62790763
95Rap1 signaling pathway_Homo sapiens_hsa040150.62758568
96Fanconi anemia pathway_Homo sapiens_hsa034600.62332439
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61680527
98Hematopoietic cell lineage_Homo sapiens_hsa046400.61346749
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61262303
100Arginine and proline metabolism_Homo sapiens_hsa003300.61252146
101mTOR signaling pathway_Homo sapiens_hsa041500.61219194
102Colorectal cancer_Homo sapiens_hsa052100.60248385
103Insulin resistance_Homo sapiens_hsa049310.60010375
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59623931
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59150440
106Glutathione metabolism_Homo sapiens_hsa004800.57624891
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57480004
108Galactose metabolism_Homo sapiens_hsa000520.57140410
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56766536
110VEGF signaling pathway_Homo sapiens_hsa043700.56060639
111Ovarian steroidogenesis_Homo sapiens_hsa049130.55178136
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53579185
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53373150
114Asthma_Homo sapiens_hsa053100.53183046
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53053610
116Type II diabetes mellitus_Homo sapiens_hsa049300.52642273
117Lysosome_Homo sapiens_hsa041420.52417419
118Tuberculosis_Homo sapiens_hsa051520.52206245
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51465108
120Sphingolipid metabolism_Homo sapiens_hsa006000.51447131
121Hepatitis B_Homo sapiens_hsa051610.51116637
122Fatty acid biosynthesis_Homo sapiens_hsa000610.50918976
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50905791
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50401672
125Circadian entrainment_Homo sapiens_hsa047130.49873227
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.48972078
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48191833
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.48170300
129TNF signaling pathway_Homo sapiens_hsa046680.48120633
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47796683
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47518485
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47509110
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47047692
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47029784
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47005676
136ABC transporters_Homo sapiens_hsa020100.46705736
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46545616
138Thyroid hormone synthesis_Homo sapiens_hsa049180.45971337
139Melanogenesis_Homo sapiens_hsa049160.45898726
140Vibrio cholerae infection_Homo sapiens_hsa051100.45610076
141Renin-angiotensin system_Homo sapiens_hsa046140.45224719
142Influenza A_Homo sapiens_hsa051640.43895740
143Fatty acid degradation_Homo sapiens_hsa000710.42837039
144Cholinergic synapse_Homo sapiens_hsa047250.42530792
145FoxO signaling pathway_Homo sapiens_hsa040680.42117131
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41012557
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.40836649
148Measles_Homo sapiens_hsa051620.40621044
149Renal cell carcinoma_Homo sapiens_hsa052110.39789877

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