PLEKHA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13813438
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.62040327
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38689948
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32783617
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27056366
6vocalization behavior (GO:0071625)4.21780503
7synaptic transmission, glutamatergic (GO:0035249)4.19941867
8glutamate receptor signaling pathway (GO:0007215)4.15084328
9glutamate secretion (GO:0014047)3.97859604
10synaptic vesicle docking involved in exocytosis (GO:0016081)3.97572212
11locomotory exploration behavior (GO:0035641)3.95650582
12cilium movement (GO:0003341)3.83031839
13neuron-neuron synaptic transmission (GO:0007270)3.79638632
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76263162
15neurotransmitter-gated ion channel clustering (GO:0072578)3.75652026
16epithelial cilium movement (GO:0003351)3.74635826
17G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71071521
18protein localization to synapse (GO:0035418)3.69702412
19positive regulation of synapse maturation (GO:0090129)3.67806902
20synaptic vesicle maturation (GO:0016188)3.64129501
21cerebellar Purkinje cell differentiation (GO:0021702)3.62972338
22regulation of glutamate receptor signaling pathway (GO:1900449)3.58247176
23behavioral fear response (GO:0001662)3.54145241
24behavioral defense response (GO:0002209)3.54145241
25membrane depolarization during action potential (GO:0086010)3.52630913
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.49676142
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49476291
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.47276766
29regulation of translation, ncRNA-mediated (GO:0045974)3.47276766
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.47276766
31regulation of neuronal synaptic plasticity (GO:0048168)3.44996525
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43485516
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40740461
34limb bud formation (GO:0060174)3.39541453
35intraciliary transport (GO:0042073)3.39203204
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32871364
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29605382
38somite development (GO:0061053)3.26928123
39presynaptic membrane assembly (GO:0097105)3.26894105
40neurotransmitter secretion (GO:0007269)3.26653781
41transmission of nerve impulse (GO:0019226)3.26182538
42behavioral response to nicotine (GO:0035095)3.20103905
43axonemal dynein complex assembly (GO:0070286)3.19983992
44regulation of synapse structural plasticity (GO:0051823)3.18332137
45regulation of gene silencing by RNA (GO:0060966)3.18247280
46regulation of posttranscriptional gene silencing (GO:0060147)3.18247280
47regulation of gene silencing by miRNA (GO:0060964)3.18247280
48regulation of postsynaptic membrane potential (GO:0060078)3.16149564
49neuron recognition (GO:0008038)3.15463394
50fear response (GO:0042596)3.14983909
51central nervous system projection neuron axonogenesis (GO:0021952)3.13411528
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12633572
53inner ear receptor cell development (GO:0060119)3.09856655
54synaptic vesicle exocytosis (GO:0016079)3.09534278
55neural tube formation (GO:0001841)3.09385534
56exploration behavior (GO:0035640)3.08355379
57establishment of nucleus localization (GO:0040023)3.06834832
58regulation of non-canonical Wnt signaling pathway (GO:2000050)3.06771666
59long-term memory (GO:0007616)3.06298134
60dendritic spine morphogenesis (GO:0060997)3.05294229
61gamma-aminobutyric acid transport (GO:0015812)3.03742924
62layer formation in cerebral cortex (GO:0021819)3.03062956
63prepulse inhibition (GO:0060134)3.02584352
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02409306
65cilium organization (GO:0044782)3.02129284
66neuronal action potential propagation (GO:0019227)3.01334459
67regulation of synaptic transmission, glutamatergic (GO:0051966)2.99920967
68cilium assembly (GO:0042384)2.99610999
69dendrite morphogenesis (GO:0048813)2.99536559
70positive regulation of dendritic spine morphogenesis (GO:0061003)2.98739279
71regulation of dendritic spine morphogenesis (GO:0061001)2.98518409
72nonmotile primary cilium assembly (GO:0035058)2.95097288
73cilium morphogenesis (GO:0060271)2.93156777
74striatum development (GO:0021756)2.92774283
75regulation of synapse maturation (GO:0090128)2.91860210
76regulation of synaptic vesicle exocytosis (GO:2000300)2.91594863
77presynaptic membrane organization (GO:0097090)2.91132060
78negative regulation of hormone metabolic process (GO:0032351)2.90400810
79negative regulation of hormone biosynthetic process (GO:0032353)2.90400810
80embryonic foregut morphogenesis (GO:0048617)2.89640120
81neuron cell-cell adhesion (GO:0007158)2.89417154
82membrane depolarization (GO:0051899)2.89229053
83auditory behavior (GO:0031223)2.87805962
84kidney morphogenesis (GO:0060993)2.87548744
85neuromuscular process controlling balance (GO:0050885)2.84922112
86response to amphetamine (GO:0001975)2.84700832
87calcium ion import (GO:0070509)2.84288229
88regulation of synaptic plasticity (GO:0048167)2.84141933
89retinal ganglion cell axon guidance (GO:0031290)2.83706219
90indolalkylamine metabolic process (GO:0006586)2.82813522
91regulation of synaptic vesicle transport (GO:1902803)2.81915312
92axonal fasciculation (GO:0007413)2.81470925
93dendritic spine organization (GO:0097061)2.80098147
94response to pheromone (GO:0019236)2.79634191
95axoneme assembly (GO:0035082)2.77070567
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76833353
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.76465022
98limb development (GO:0060173)2.76321921
99appendage development (GO:0048736)2.76321921
100replication fork processing (GO:0031297)2.73436616
101lateral sprouting from an epithelium (GO:0060601)2.73040178
102cell communication by electrical coupling (GO:0010644)2.72760381
103ephrin receptor signaling pathway (GO:0048013)2.72645422
104neuronal ion channel clustering (GO:0045161)2.72642617
105chemosensory behavior (GO:0007635)2.70896923
106indole-containing compound catabolic process (GO:0042436)2.70508470
107indolalkylamine catabolic process (GO:0046218)2.70508470
108tryptophan catabolic process (GO:0006569)2.70508470
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70482328
110positive regulation of membrane potential (GO:0045838)2.70473900
111suckling behavior (GO:0001967)2.69652255
112otic vesicle formation (GO:0030916)2.67396833
113photoreceptor cell maintenance (GO:0045494)2.67024427
114proline transport (GO:0015824)2.66928873
115behavioral response to cocaine (GO:0048148)2.65451658
116regulation of mesoderm development (GO:2000380)2.65358592
117negative regulation of axon guidance (GO:1902668)2.64012832
118regulation of vesicle fusion (GO:0031338)2.63891300
119cochlea development (GO:0090102)2.63401118
120cellular potassium ion homeostasis (GO:0030007)2.63049674
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61245886
122serotonin metabolic process (GO:0042428)2.59590550
123DNA double-strand break processing (GO:0000729)2.59367239
124hindbrain development (GO:0030902)2.59283058
125cilium or flagellum-dependent cell motility (GO:0001539)2.59084866
126learning (GO:0007612)2.58641215
127kynurenine metabolic process (GO:0070189)2.57672523
128neurotransmitter transport (GO:0006836)2.57641937
129spinal cord motor neuron differentiation (GO:0021522)2.57348918
130neuromuscular process (GO:0050905)2.56922745
131gamma-aminobutyric acid signaling pathway (GO:0007214)2.56841757
132cellular sodium ion homeostasis (GO:0006883)2.56806472
133membrane hyperpolarization (GO:0060081)2.56709265
134regulation of glutamate secretion (GO:0014048)2.54837148
135glycine transport (GO:0015816)2.54283942
136pyrimidine nucleobase catabolic process (GO:0006208)2.54121551
137cell migration in hindbrain (GO:0021535)2.54103950
138regulation of respiratory gaseous exchange (GO:0043576)2.54046607
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.54041823
140lung-associated mesenchyme development (GO:0060484)2.53479839
141long-term synaptic potentiation (GO:0060291)2.52323740
142central nervous system neuron axonogenesis (GO:0021955)2.51576718
143regulation of respiratory system process (GO:0044065)2.51551523
144centriole replication (GO:0007099)2.50757250
145neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50756862
146atrial cardiac muscle cell action potential (GO:0086014)2.49895233
147innervation (GO:0060384)2.48438494
148protein localization to cilium (GO:0061512)2.47339282
149calcium ion-dependent exocytosis (GO:0017156)2.47316020
150dorsal/ventral axis specification (GO:0009950)2.47042604
151tryptophan metabolic process (GO:0006568)2.46565064
152inner ear receptor stereocilium organization (GO:0060122)2.46157616
153smoothened signaling pathway (GO:0007224)2.46021832
154cellular component assembly involved in morphogenesis (GO:0010927)2.45902751
155negative regulation of DNA-dependent DNA replication (GO:2000104)2.45397672
156regulation of hippo signaling (GO:0035330)2.42988178
157sympathetic nervous system development (GO:0048485)2.41182109
158sulfation (GO:0051923)2.40652424
159behavioral response to ethanol (GO:0048149)2.39686628
160artery development (GO:0060840)2.39311204
161postsynaptic membrane organization (GO:0001941)2.38805337
162retinal cone cell development (GO:0046549)2.36538008
163somite rostral/caudal axis specification (GO:0032525)2.36195897
164negative regulation of astrocyte differentiation (GO:0048712)2.34683717
165prostate gland growth (GO:0060736)2.33608016
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32850040
167regulation of cilium movement (GO:0003352)2.31025700
168embryonic pattern specification (GO:0009880)2.30777756
169axon extension involved in axon guidance (GO:0048846)2.30460550
170neuron projection extension involved in neuron projection guidance (GO:1902284)2.30460550
171retina layer formation (GO:0010842)2.29793700
172regulation of meiosis I (GO:0060631)2.27569350
173reflex (GO:0060004)2.27262167
174determination of left/right symmetry (GO:0007368)2.27121585
175thalamus development (GO:0021794)2.26925820
176cytoplasmic mRNA processing body assembly (GO:0033962)2.26704683
177microtubule anchoring (GO:0034453)2.26256111
178negative chemotaxis (GO:0050919)2.25630988
179detection of mechanical stimulus involved in sensory perception (GO:0050974)2.25429953
180photoreceptor cell development (GO:0042461)2.24185463
181regulation of collateral sprouting (GO:0048670)2.23436208
182microtubule polymerization or depolymerization (GO:0031109)2.23324280
183resolution of meiotic recombination intermediates (GO:0000712)2.22733647
184DNA integration (GO:0015074)2.22715362
185determination of bilateral symmetry (GO:0009855)2.22282949
186L-fucose catabolic process (GO:0042355)2.21958746
187fucose catabolic process (GO:0019317)2.21958746
188L-fucose metabolic process (GO:0042354)2.21958746
189left/right axis specification (GO:0070986)2.20530547
190embryonic axis specification (GO:0000578)2.18526820
191sex differentiation (GO:0007548)2.17514168
192regulation of sarcomere organization (GO:0060297)2.16277235
193specification of symmetry (GO:0009799)2.16204791
194positive regulation of embryonic development (GO:0040019)2.14830904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67207714
2GBX2_23144817_ChIP-Seq_PC3_Human3.52753262
3VDR_22108803_ChIP-Seq_LS180_Human2.84111065
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73382375
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51032174
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50078048
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46952476
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46712500
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42450228
10DROSHA_22980978_ChIP-Seq_HELA_Human2.32196258
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32142686
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32142686
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24045463
14EWS_26573619_Chip-Seq_HEK293_Human2.23317286
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.22885336
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.16134604
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11825431
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08775325
19IGF1R_20145208_ChIP-Seq_DFB_Human2.07731630
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.07651362
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.07554586
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01836420
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99742763
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99134155
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98470345
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95103120
27REST_21632747_ChIP-Seq_MESCs_Mouse1.92053062
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.89092036
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.79872809
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77553652
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74516273
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72205965
33SMAD4_21799915_ChIP-Seq_A2780_Human1.68631670
34TAF15_26573619_Chip-Seq_HEK293_Human1.68038427
35* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65482179
36ER_23166858_ChIP-Seq_MCF-7_Human1.62705341
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59659160
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54765810
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53839402
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.51766467
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51302314
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47199822
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46112566
44AHR_22903824_ChIP-Seq_MCF-7_Human1.44841781
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.44441976
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44080884
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.41813040
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41325958
49CBP_20019798_ChIP-Seq_JUKART_Human1.40538962
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40538962
51STAT3_23295773_ChIP-Seq_U87_Human1.38654876
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.38459469
53* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38119314
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37892457
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.37798040
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37515109
57* TCF4_22108803_ChIP-Seq_LS180_Human1.36387248
58FUS_26573619_Chip-Seq_HEK293_Human1.35958394
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35489647
60ZNF274_21170338_ChIP-Seq_K562_Hela1.35070507
61P300_19829295_ChIP-Seq_ESCs_Human1.32276590
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31192951
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29695546
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28734371
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27938665
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27617651
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.27229795
68AR_19668381_ChIP-Seq_PC3_Human1.27208768
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25264051
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24868262
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24278473
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22611250
73* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22253673
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.22108980
75* TCF4_23295773_ChIP-Seq_U87_Human1.21578710
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21492781
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20800385
78AR_25329375_ChIP-Seq_VCAP_Human1.20712928
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20547152
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19899989
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.19826276
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19741434
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.19152206
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19147101
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.18880476
86RNF2_27304074_Chip-Seq_NSC_Mouse1.18465703
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17868508
88* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17126435
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16724685
90* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16361354
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.16138521
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15784110
93AR_21572438_ChIP-Seq_LNCaP_Human1.15702577
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15618865
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15185593
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15185593
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14614715
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.12409470
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10853039
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10680207
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09714440
102SOX2_19829295_ChIP-Seq_ESCs_Human1.09604478
103NANOG_19829295_ChIP-Seq_ESCs_Human1.09604478
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08425226
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07334462
106BCAT_22108803_ChIP-Seq_LS180_Human1.06926248
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.04992845
108P53_22387025_ChIP-Seq_ESCs_Mouse1.04836765
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04821107
110IRF1_19129219_ChIP-ChIP_H3396_Human1.04762526
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04419154
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.04344014
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.04131081
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03907573
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03485097
116TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03232266
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03071438
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03062405
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03040086
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02549770
121SOX9_26525672_Chip-Seq_HEART_Mouse1.01703482
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01177175
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01072962
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00971914
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00066664
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.00029328
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.99680057
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.99562007
129HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99066989
130KDM2B_26808549_Chip-Seq_REH_Human0.99018891
131* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98364918
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97719664
133TBL1_22424771_ChIP-Seq_293T_Human0.97601662
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.97250561
135RUNX2_22187159_ChIP-Seq_PCA_Human0.97223169
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97128059
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95207620
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94436987
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94172726
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.93846385
141KDM2B_26808549_Chip-Seq_K562_Human0.93786868
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92258517
143* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92053833
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91829052
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91472215
146TP53_16413492_ChIP-PET_HCT116_Human0.91257630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53164309
2MP0003880_abnormal_central_pattern3.46783902
3MP0003635_abnormal_synaptic_transmissio3.22191666
4MP0002822_catalepsy3.02135875
5MP0003136_yellow_coat_color2.95403016
6MP0009745_abnormal_behavioral_response2.84519053
7MP0002063_abnormal_learning/memory/cond2.69093587
8MP0002102_abnormal_ear_morphology2.68705357
9MP0004270_analgesia2.47937496
10MP0002572_abnormal_emotion/affect_behav2.32988265
11MP0002938_white_spotting2.30722637
12MP0001501_abnormal_sleep_pattern2.28848589
13MP0001968_abnormal_touch/_nociception2.27500223
14MP0009046_muscle_twitch2.25774499
15MP0002064_seizures2.20402975
16MP0000383_abnormal_hair_follicle2.07193940
17MP0001486_abnormal_startle_reflex2.07175477
18MP0008877_abnormal_DNA_methylation2.06465700
19MP0002736_abnormal_nociception_after2.02646158
20MP0002735_abnormal_chemical_nociception2.01323272
21MP0002272_abnormal_nervous_system1.99390376
22MP0000569_abnormal_digit_pigmentation1.95661327
23MP0005423_abnormal_somatic_nervous1.95230193
24MP0003937_abnormal_limbs/digits/tail_de1.93895762
25MP0006292_abnormal_olfactory_placode1.87853883
26MP0001293_anophthalmia1.81013787
27MP0008057_abnormal_DNA_replication1.78228503
28MP0000372_irregular_coat_pigmentation1.73916740
29MP0003787_abnormal_imprinting1.73764061
30MP0005171_absent_coat_pigmentation1.71962445
31MP0004885_abnormal_endolymph1.71137247
32MP0000778_abnormal_nervous_system1.69982189
33MP0003195_calcinosis1.67898658
34MP0002184_abnormal_innervation1.66319908
35MP0004133_heterotaxia1.65101745
36MP0002067_abnormal_sensory_capabilities1.63974385
37MP0003123_paternal_imprinting1.61801602
38MP0001440_abnormal_grooming_behavior1.60996770
39MP0002557_abnormal_social/conspecific_i1.60802969
40MP0002734_abnormal_mechanical_nocicepti1.56742068
41MP0002282_abnormal_trachea_morphology1.54956999
42MP0002909_abnormal_adrenal_gland1.53663187
43MP0002837_dystrophic_cardiac_calcinosis1.52496458
44MP0001188_hyperpigmentation1.51268643
45MP0005253_abnormal_eye_physiology1.51231498
46MP0008961_abnormal_basal_metabolism1.50364102
47MP0000955_abnormal_spinal_cord1.48912026
48MP0003122_maternal_imprinting1.46531760
49MP0006072_abnormal_retinal_apoptosis1.41186034
50MP0001984_abnormal_olfaction1.38958338
51MP0002638_abnormal_pupillary_reflex1.38911893
52MP0008569_lethality_at_weaning1.35302104
53MP0003718_maternal_effect1.33637789
54MP0005386_behavior/neurological_phenoty1.29382883
55MP0004924_abnormal_behavior1.29382883
56MP0001324_abnormal_eye_pigmentation1.28199872
57MP0000427_abnormal_hair_cycle1.27450703
58MP0010678_abnormal_skin_adnexa1.26808672
59MP0004147_increased_porphyrin_level1.25382157
60MP0003283_abnormal_digestive_organ1.25204785
61MP0002234_abnormal_pharynx_morphology1.24613587
62MP0010030_abnormal_orbit_morphology1.24489278
63MP0002751_abnormal_autonomic_nervous1.24286966
64MP0002882_abnormal_neuron_morphology1.22460594
65MP0009780_abnormal_chondrocyte_physiolo1.21995545
66MP0003890_abnormal_embryonic-extraembry1.21989991
67MP0004811_abnormal_neuron_physiology1.19924391
68MP0000566_synostosis1.18710945
69MP0004215_abnormal_myocardial_fiber1.17580259
70MP0002733_abnormal_thermal_nociception1.17568696
71MP0001970_abnormal_pain_threshold1.15762976
72MP0003646_muscle_fatigue1.14293671
73MP0003121_genomic_imprinting1.14135756
74MP0003879_abnormal_hair_cell1.14056590
75MP0005174_abnormal_tail_pigmentation1.13959700
76MP0005394_taste/olfaction_phenotype1.12509371
77MP0005499_abnormal_olfactory_system1.12509371
78MP0001502_abnormal_circadian_rhythm1.11910608
79MP0004043_abnormal_pH_regulation1.07545849
80MP0003941_abnormal_skin_development1.07507200
81MP0000631_abnormal_neuroendocrine_gland1.07439347
82MP0003938_abnormal_ear_development1.07190392
83MP0001485_abnormal_pinna_reflex1.07158523
84MP0005646_abnormal_pituitary_gland1.06897008
85MP0000534_abnormal_ureter_morphology1.06803777
86MP0003385_abnormal_body_wall1.05436346
87MP0000647_abnormal_sebaceous_gland1.04939204
88MP0000049_abnormal_middle_ear1.03921573
89MP0003137_abnormal_impulse_conducting1.02943642
90MP0006276_abnormal_autonomic_nervous1.02942525
91MP0001299_abnormal_eye_distance/1.01609587
92MP0002152_abnormal_brain_morphology1.01590097
93MP0005391_vision/eye_phenotype1.01149829
94MP0002066_abnormal_motor_capabilities/c1.00724184
95MP0001286_abnormal_eye_development1.00487135
96MP0005187_abnormal_penis_morphology0.99675270
97MP0002697_abnormal_eye_size0.99045768
98MP0005367_renal/urinary_system_phenotyp0.98641063
99MP0000516_abnormal_urinary_system0.98641063
100MP0008789_abnormal_olfactory_epithelium0.98388725
101MP0005377_hearing/vestibular/ear_phenot0.96823493
102MP0003878_abnormal_ear_physiology0.96823493
103MP0005195_abnormal_posterior_eye0.95314044
104MP0000537_abnormal_urethra_morphology0.94864951
105MP0000579_abnormal_nail_morphology0.94275225
106MP0002249_abnormal_larynx_morphology0.94274115
107MP0003755_abnormal_palate_morphology0.94237578
108MP0005248_abnormal_Harderian_gland0.92387813
109MP0000678_abnormal_parathyroid_gland0.91273690
110MP0005645_abnormal_hypothalamus_physiol0.90897203
111MP0003861_abnormal_nervous_system0.90864250
112MP0004510_myositis0.90820154
113MP0001177_atelectasis0.89874349
114MP0002233_abnormal_nose_morphology0.89697053
115MP0003567_abnormal_fetal_cardiomyocyte0.89383522
116MP0005409_darkened_coat_color0.87675884
117MP0008995_early_reproductive_senescence0.87062514
118MP0004085_abnormal_heartbeat0.85958623
119MP0002069_abnormal_eating/drinking_beha0.84758382
120MP0004142_abnormal_muscle_tone0.84359438
121MP0010234_abnormal_vibrissa_follicle0.84111488
122MP0002095_abnormal_skin_pigmentation0.83761822
123MP0004145_abnormal_muscle_electrophysio0.83293979
124MP0004858_abnormal_nervous_system0.82985086
125MP0003935_abnormal_craniofacial_develop0.82621780
126MP0008058_abnormal_DNA_repair0.82445347
127MP0010386_abnormal_urinary_bladder0.81371061
128MP0002752_abnormal_somatic_nervous0.79607832
129MP0003119_abnormal_digestive_system0.79366394
130MP0005623_abnormal_meninges_morphology0.77597219
131MP0002653_abnormal_ependyma_morphology0.75084198
132MP0005670_abnormal_white_adipose0.74023420
133MP0005551_abnormal_eye_electrophysiolog0.73214249
134MP0001963_abnormal_hearing_physiology0.72933408
135MP0001529_abnormal_vocalization0.72102934
136MP0000026_abnormal_inner_ear0.70782068
137MP0003942_abnormal_urinary_system0.67693992
138MP0001849_ear_inflammation0.67214446
139MP0003698_abnormal_male_reproductive0.66745242
140MP0005410_abnormal_fertilization0.66600314
141MP0008872_abnormal_physiological_respon0.64623079
142MP0002082_postnatal_lethality0.63938429
143MP0010770_preweaning_lethality0.63938429

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.72116430
2Myokymia (HP:0002411)4.05234351
3Pancreatic fibrosis (HP:0100732)4.03453115
4Pancreatic cysts (HP:0001737)3.94712490
5Focal seizures (HP:0007359)3.91624239
6True hermaphroditism (HP:0010459)3.88331169
7Febrile seizures (HP:0002373)3.69821177
8Molar tooth sign on MRI (HP:0002419)3.46697571
9Abnormality of midbrain morphology (HP:0002418)3.46697571
10Progressive cerebellar ataxia (HP:0002073)3.41495728
11Epileptic encephalopathy (HP:0200134)3.38725043
12Abnormal ciliary motility (HP:0012262)3.30626237
13Blue irides (HP:0000635)3.20670772
14Abnormality of the lower motor neuron (HP:0002366)3.03474724
15Genetic anticipation (HP:0003743)3.01614457
16Medial flaring of the eyebrow (HP:0010747)3.00301073
17Abnormal respiratory motile cilium physiology (HP:0012261)2.99115461
18Gaze-evoked nystagmus (HP:0000640)2.93293314
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.91898942
20Abnormal respiratory motile cilium morphology (HP:0005938)2.86836769
21Abnormal respiratory epithelium morphology (HP:0012253)2.86836769
22Birth length less than 3rd percentile (HP:0003561)2.86164777
23Broad-based gait (HP:0002136)2.77906238
24Gait imbalance (HP:0002141)2.72151638
25Cystic liver disease (HP:0006706)2.71668865
26Genital tract atresia (HP:0001827)2.69345009
27Congenital primary aphakia (HP:0007707)2.65788305
28Vaginal atresia (HP:0000148)2.62128032
29Abnormality of the labia minora (HP:0012880)2.58287753
30Atonic seizures (HP:0010819)2.57708057
31Rhinitis (HP:0012384)2.56725416
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.55667000
33Drooling (HP:0002307)2.49302474
34Excessive salivation (HP:0003781)2.49302474
35Abnormality of the renal cortex (HP:0011035)2.47350722
36Impaired smooth pursuit (HP:0007772)2.43823002
37Dysmetric saccades (HP:0000641)2.39607027
38Postaxial foot polydactyly (HP:0001830)2.37739098
39Cutaneous finger syndactyly (HP:0010554)2.36415406
40Protruding tongue (HP:0010808)2.35296097
41Nephrogenic diabetes insipidus (HP:0009806)2.33922236
42Action tremor (HP:0002345)2.33619847
43Congenital stationary night blindness (HP:0007642)2.33272017
44Sclerocornea (HP:0000647)2.33239025
45Bilateral microphthalmos (HP:0007633)2.31793812
46Tubular atrophy (HP:0000092)2.29852595
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.27491898
48Oligodactyly (hands) (HP:0001180)2.26240217
49Visual hallucinations (HP:0002367)2.25616194
50Anencephaly (HP:0002323)2.24781296
51Absence seizures (HP:0002121)2.24472527
52Preaxial foot polydactyly (HP:0001841)2.23505151
53Poor coordination (HP:0002370)2.22822114
54Preaxial hand polydactyly (HP:0001177)2.20373170
55Generalized tonic-clonic seizures (HP:0002069)2.20142272
56Hypoventilation (HP:0002791)2.19378919
57Bundle branch block (HP:0011710)2.18705299
58Congenital hepatic fibrosis (HP:0002612)2.18432735
59Occipital encephalocele (HP:0002085)2.15785156
60Labial hypoplasia (HP:0000066)2.14699225
61Dysdiadochokinesis (HP:0002075)2.13814159
62Lower limb amyotrophy (HP:0007210)2.10514189
63Decreased circulating renin level (HP:0003351)2.10284717
64Generalized hypopigmentation of hair (HP:0011358)2.10138705
65Postaxial hand polydactyly (HP:0001162)2.09117166
66Abnormality of ocular smooth pursuit (HP:0000617)2.03594609
67Scanning speech (HP:0002168)2.03286833
68Dialeptic seizures (HP:0011146)2.02329814
69Intestinal atresia (HP:0011100)2.01042334
70Pointed chin (HP:0000307)1.99810249
71Cutaneous syndactyly (HP:0012725)1.99622037
72Limb-girdle muscle atrophy (HP:0003797)1.99207380
73Male pseudohermaphroditism (HP:0000037)1.98110063
74Amblyopia (HP:0000646)1.97881466
75Obsessive-compulsive behavior (HP:0000722)1.97362638
76Absent speech (HP:0001344)1.97342999
77Short hallux (HP:0010109)1.97059347
78Abnormal social behavior (HP:0012433)1.95832625
79Impaired social interactions (HP:0000735)1.95832625
80Hyperventilation (HP:0002883)1.94806821
81Poor eye contact (HP:0000817)1.94793774
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.94610180
83Aplasia/Hypoplasia of the hallux (HP:0008362)1.93465488
84Aqueductal stenosis (HP:0002410)1.91563648
85Bifid tongue (HP:0010297)1.91459178
86Abnormality of the musculature of the pelvis (HP:0001469)1.90474982
87Abnormality of the hip-girdle musculature (HP:0001445)1.90474982
88Nephronophthisis (HP:0000090)1.90138413
89Hypoplastic female external genitalia (HP:0012815)1.89497982
90Ventricular fibrillation (HP:0001663)1.89309952
91Impaired vibration sensation in the lower limbs (HP:0002166)1.89250138
92Furrowed tongue (HP:0000221)1.88574934
93Torticollis (HP:0000473)1.87629613
94Bronchomalacia (HP:0002780)1.87178723
95Abnormal biliary tract physiology (HP:0012439)1.86747421
96Bile duct proliferation (HP:0001408)1.86747421
97Urinary bladder sphincter dysfunction (HP:0002839)1.86387118
98Supernumerary spleens (HP:0009799)1.86375385
99Patellar aplasia (HP:0006443)1.85940138
100Annular pancreas (HP:0001734)1.85509424
101Congenital, generalized hypertrichosis (HP:0004540)1.84849293
102Decreased central vision (HP:0007663)1.84575286
103Colon cancer (HP:0003003)1.82867501
104Concave nail (HP:0001598)1.81009183
105Septo-optic dysplasia (HP:0100842)1.80759746
106Optic nerve hypoplasia (HP:0000609)1.80210324
107Postural instability (HP:0002172)1.79881567
108Abnormality of the labia majora (HP:0012881)1.79551118
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.79328449
110Dysmetria (HP:0001310)1.79131956
111Cerebellar dysplasia (HP:0007033)1.78458439
112Shoulder girdle muscle weakness (HP:0003547)1.77254389
113Small hand (HP:0200055)1.76880465
114Abolished electroretinogram (ERG) (HP:0000550)1.76780411
115Dandy-Walker malformation (HP:0001305)1.76502483
116Gastrointestinal atresia (HP:0002589)1.76429734
117Prolonged QT interval (HP:0001657)1.76253574
118Proximal amyotrophy (HP:0007126)1.75763482
119Increased corneal curvature (HP:0100692)1.75635431
120Keratoconus (HP:0000563)1.75635431
121Type II lissencephaly (HP:0007260)1.75378981
122Narrow forehead (HP:0000341)1.74857363
123Broad distal phalanx of finger (HP:0009836)1.74363270
124Narrow nasal bridge (HP:0000446)1.73591966
125Tubulointerstitial nephritis (HP:0001970)1.73481526
126Papillary thyroid carcinoma (HP:0002895)1.72410073
127Anophthalmia (HP:0000528)1.72179971
128Morphological abnormality of the middle ear (HP:0008609)1.71258343
129Chromsome breakage (HP:0040012)1.70966389
130Absent eyebrow (HP:0002223)1.70256062
131Short foot (HP:0001773)1.69964971
132Chronic bronchitis (HP:0004469)1.69396157
133Aplasia/Hypoplasia of the patella (HP:0006498)1.69235985
134Astigmatism (HP:0000483)1.68874965
135Specific learning disability (HP:0001328)1.67518322
136Exotropia (HP:0000577)1.67176262
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66230221
138Turricephaly (HP:0000262)1.66188538
139Volvulus (HP:0002580)1.66027621
140Oligodactyly (HP:0012165)1.65585680
141Hyperkalemia (HP:0002153)1.65573727
142Fair hair (HP:0002286)1.65550907
143Cupped ear (HP:0000378)1.65339583
144Pendular nystagmus (HP:0012043)1.64754845
145Glioma (HP:0009733)1.64494950
146Epileptiform EEG discharges (HP:0011182)1.63872779
147Abnormality of the renal medulla (HP:0100957)1.63299552
148Gastroesophageal reflux (HP:0002020)1.63098823
149Renal duplication (HP:0000075)1.63011462
150Status epilepticus (HP:0002133)1.62960706
151Chronic hepatic failure (HP:0100626)1.62732335
152Atrioventricular block (HP:0001678)1.62563475
153Progressive sensorineural hearing impairment (HP:0000408)1.62356770
154Abnormal EKG (HP:0003115)1.62293958
155Absent/shortened dynein arms (HP:0200106)1.61546138
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.61546138
157Hemiplegia (HP:0002301)1.59684317
158Hypoplastic labia majora (HP:0000059)1.59076970
159Truncal ataxia (HP:0002078)1.57638702
160Renovascular hypertension (HP:0100817)1.57136630
161Midline defect of the nose (HP:0004122)1.56916693
162Heart block (HP:0012722)1.56891392
163Atrial fibrillation (HP:0005110)1.56218784
164Renal hypoplasia (HP:0000089)1.55685844
165Syncope (HP:0001279)1.55048086
166Aplasia involving bones of the extremities (HP:0009825)1.51655340
167Aplasia involving bones of the upper limbs (HP:0009823)1.51655340
168Aplasia of the phalanges of the hand (HP:0009802)1.51655340
169Primary atrial arrhythmia (HP:0001692)1.51178321
170Hyperactive renin-angiotensin system (HP:0000841)1.49286120
171Lip pit (HP:0100267)1.49158540
172Hemiparesis (HP:0001269)1.48448038
173Nonprogressive disorder (HP:0003680)1.47957630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.79783714
2NTRK34.70764088
3ACVR1B2.89180724
4MAP3K92.52652482
5TNIK2.31480741
6MAP3K42.28760614
7NTRK22.05555642
8DAPK21.94506891
9MKNK11.81340038
10NUAK11.80822175
11CASK1.79263316
12PRKD31.73573266
13CAMKK11.73059845
14SGK21.72854347
15OXSR11.71207634
16ZAK1.70562755
17MARK21.63932893
18MARK11.62456011
19AKT31.61352797
20CAMKK21.56572935
21GRK11.55650673
22STK391.52354636
23KSR11.51599790
24MAPK131.50055134
25WEE11.49245165
26LATS11.49028109
27ADRBK21.47237329
28STK381.47208157
29MAP2K71.47026466
30TGFBR11.46837462
31BRSK21.43443019
32PAK61.43270816
33MAP4K21.43223094
34SGK31.35034091
35MINK11.34258800
36BRD41.33642765
37STK241.33368375
38MAPK151.30822256
39LATS21.30203919
40BCR1.29973704
41TYRO31.29491419
42SGK2231.27828248
43SGK4941.27828248
44LMTK21.19158932
45KSR21.16918064
46TAOK21.16910297
47MAP2K41.12600270
48STK31.10381065
49INSRR1.08745806
50FGFR21.07402921
51CDC71.07383592
52SIK21.07158476
53MAP3K21.07023870
54TAOK11.06532528
55PLK21.03336094
56TRIM281.03176385
57PLK31.02327760
58PAK31.01484412
59WNK41.00265573
60SGK10.98765105
61CDK50.98643274
62MKNK20.98484113
63PDGFRA0.97111589
64DMPK0.96805012
65MAP3K130.95255379
66PLK40.92677544
67PRPF4B0.92282922
68MST40.92116873
69DAPK10.90105932
70VRK10.89023181
71CDC42BPA0.88734009
72CAMK1G0.88691279
73PRKCG0.86554917
74PDK40.85889599
75PDK30.85889599
76DYRK20.83150929
77WNK10.83096195
78MAP3K70.82788705
79DYRK1A0.81546259
80STK160.81002623
81FGFR10.80616707
82SIK30.80526430
83PRKCH0.80346525
84ADRBK10.80056145
85CAMK2B0.79089931
86CDK190.79005545
87CSNK1G20.78218562
88CAMK10.77785441
89CSNK1G10.76936997
90PTK2B0.75894543
91PRKD20.73889846
92CAMK2A0.73814396
93FER0.73003249
94STK110.72750269
95NEK20.72513311
96NEK60.71605220
97PLK10.70648322
98TAF10.70250715
99OBSCN0.69268746
100WNK30.67115188
101PINK10.66896524
102TTK0.65201436
103CDK120.64201546
104RET0.63861167
105EPHB20.63237073
106CDK30.61898510
107UHMK10.60131902
108CAMK1D0.60082572
109PNCK0.59333297
110MET0.58456631
111RPS6KA30.57857900
112SRPK10.56844382
113ALK0.56234455
114BMPR1B0.56163124
115NME10.55007663
116PTK20.54846138
117CSNK1A1L0.54603585
118PIK3CA0.53502136
119DDR20.52262139
120PKN10.51677211
121RIPK10.50676802
122CSNK1G30.50643353
123ATM0.49945887
124CHEK20.48980000
125TSSK60.48624743
126CAMK40.47016785
127GSK3B0.47009669
128FLT30.46479630
129PRKCE0.46469460
130MUSK0.46210618
131STK38L0.45240950
132MST1R0.44688399
133MAP2K60.44415182
134ERBB30.44260773
135ATR0.44253983
136CSNK1E0.43549358
137TLK10.42984282
138PRKAA20.42946897
139MAP2K10.42773052
140PDGFRB0.42617768
141MAPKAPK50.42328928
142MAPK80.41652721
143PBK0.41470657
144NTRK10.40628338
145NLK0.40532310
146BMX0.40486660
147ERBB20.40485901
148PIK3CG0.40298508
149YES10.40258821
150FRK0.40122862
151TIE10.39391023
152BUB10.38748076
153DYRK30.37523817
154CSNK1A10.36744520
155CSNK1D0.35786524
156MELK0.35480663
157PRKACA0.34725330
158PRKACB0.34303486
159TAOK30.34182640

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94619666
2Circadian entrainment_Homo sapiens_hsa047132.83028876
3Glutamatergic synapse_Homo sapiens_hsa047242.71907833
4Amphetamine addiction_Homo sapiens_hsa050312.70238667
5Long-term potentiation_Homo sapiens_hsa047202.61225228
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44044300
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42804780
8GABAergic synapse_Homo sapiens_hsa047272.37153796
9Olfactory transduction_Homo sapiens_hsa047402.31795475
10Morphine addiction_Homo sapiens_hsa050322.30380193
11Synaptic vesicle cycle_Homo sapiens_hsa047212.21591655
12Cocaine addiction_Homo sapiens_hsa050302.11557781
13Propanoate metabolism_Homo sapiens_hsa006402.05968349
14Dopaminergic synapse_Homo sapiens_hsa047281.99211643
15Homologous recombination_Homo sapiens_hsa034401.98586024
16Insulin secretion_Homo sapiens_hsa049111.91630561
17Taste transduction_Homo sapiens_hsa047421.90793696
18Fanconi anemia pathway_Homo sapiens_hsa034601.89822032
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88134317
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87744636
21Salivary secretion_Homo sapiens_hsa049701.82042269
22Tryptophan metabolism_Homo sapiens_hsa003801.77473135
23Linoleic acid metabolism_Homo sapiens_hsa005911.76504857
24Cholinergic synapse_Homo sapiens_hsa047251.67076468
25Long-term depression_Homo sapiens_hsa047301.61357227
26Calcium signaling pathway_Homo sapiens_hsa040201.60896506
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60197810
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56065153
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54216411
30Renin secretion_Homo sapiens_hsa049241.53023621
31Oxytocin signaling pathway_Homo sapiens_hsa049211.51221180
32Non-homologous end-joining_Homo sapiens_hsa034501.50589979
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50461865
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49088646
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46675957
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.45171908
37Gastric acid secretion_Homo sapiens_hsa049711.43390461
38Basal transcription factors_Homo sapiens_hsa030221.41965693
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41855841
40Serotonergic synapse_Homo sapiens_hsa047261.41452484
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40265528
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40229312
43Selenocompound metabolism_Homo sapiens_hsa004501.39566030
44Axon guidance_Homo sapiens_hsa043601.39246279
45Protein export_Homo sapiens_hsa030601.38494048
46cAMP signaling pathway_Homo sapiens_hsa040241.37341793
47Type II diabetes mellitus_Homo sapiens_hsa049301.37189331
48ABC transporters_Homo sapiens_hsa020101.36509594
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34863526
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34335283
51Caffeine metabolism_Homo sapiens_hsa002321.33364984
52RNA polymerase_Homo sapiens_hsa030201.30519758
53Circadian rhythm_Homo sapiens_hsa047101.30166643
54GnRH signaling pathway_Homo sapiens_hsa049121.27708923
55Chemical carcinogenesis_Homo sapiens_hsa052041.24255386
56Retinol metabolism_Homo sapiens_hsa008301.23896667
57Melanogenesis_Homo sapiens_hsa049161.23866897
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16599038
59Ether lipid metabolism_Homo sapiens_hsa005651.16520826
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14062977
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13306126
62Histidine metabolism_Homo sapiens_hsa003401.12297338
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12110168
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08107208
65RNA degradation_Homo sapiens_hsa030181.07760482
66Huntingtons disease_Homo sapiens_hsa050161.06658362
67beta-Alanine metabolism_Homo sapiens_hsa004101.05004691
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03798005
69Estrogen signaling pathway_Homo sapiens_hsa049151.01951348
70Dorso-ventral axis formation_Homo sapiens_hsa043201.01601387
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.99745838
72Cardiac muscle contraction_Homo sapiens_hsa042600.98645249
73Dilated cardiomyopathy_Homo sapiens_hsa054140.98236107
74Oxidative phosphorylation_Homo sapiens_hsa001900.98080496
75TGF-beta signaling pathway_Homo sapiens_hsa043500.97535050
76Oocyte meiosis_Homo sapiens_hsa041140.96128606
77Gap junction_Homo sapiens_hsa045400.96037838
78Nitrogen metabolism_Homo sapiens_hsa009100.95057444
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93987012
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93677382
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.92580725
82ErbB signaling pathway_Homo sapiens_hsa040120.88843165
83Glucagon signaling pathway_Homo sapiens_hsa049220.86663808
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83850798
85Bile secretion_Homo sapiens_hsa049760.83768941
86Peroxisome_Homo sapiens_hsa041460.81779965
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80943757
88Parkinsons disease_Homo sapiens_hsa050120.80325115
89Wnt signaling pathway_Homo sapiens_hsa043100.80254303
90Arginine biosynthesis_Homo sapiens_hsa002200.79151234
91Steroid biosynthesis_Homo sapiens_hsa001000.78863955
92Pancreatic secretion_Homo sapiens_hsa049720.78620136
93Lysine degradation_Homo sapiens_hsa003100.77333855
94Tyrosine metabolism_Homo sapiens_hsa003500.75146738
95Mismatch repair_Homo sapiens_hsa034300.73832558
96Choline metabolism in cancer_Homo sapiens_hsa052310.72501395
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71184226
98One carbon pool by folate_Homo sapiens_hsa006700.70010336
99MAPK signaling pathway_Homo sapiens_hsa040100.69948755
100Fatty acid degradation_Homo sapiens_hsa000710.69925272
101Glioma_Homo sapiens_hsa052140.69910744
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69237257
103Basal cell carcinoma_Homo sapiens_hsa052170.68752512
104Thyroid hormone synthesis_Homo sapiens_hsa049180.67934367
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66507590
106Adherens junction_Homo sapiens_hsa045200.66023749
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.65942130
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65911858
109Purine metabolism_Homo sapiens_hsa002300.65891243
110Hedgehog signaling pathway_Homo sapiens_hsa043400.65793087
111Rap1 signaling pathway_Homo sapiens_hsa040150.64573858
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63892669
113Fatty acid biosynthesis_Homo sapiens_hsa000610.63149611
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63000969
115RNA transport_Homo sapiens_hsa030130.61959678
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61329333
117Inositol phosphate metabolism_Homo sapiens_hsa005620.61140828
118Vibrio cholerae infection_Homo sapiens_hsa051100.60893457
119mTOR signaling pathway_Homo sapiens_hsa041500.60564745
120Cell cycle_Homo sapiens_hsa041100.60326292
121Endometrial cancer_Homo sapiens_hsa052130.57730352
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57670193
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56992539
124Nucleotide excision repair_Homo sapiens_hsa034200.56131251
125Hippo signaling pathway_Homo sapiens_hsa043900.55604872
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55568901
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55126360
128Collecting duct acid secretion_Homo sapiens_hsa049660.54669009
129Ovarian steroidogenesis_Homo sapiens_hsa049130.54392346
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.53474818
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52613090
132Metabolic pathways_Homo sapiens_hsa011000.52151775
133Arachidonic acid metabolism_Homo sapiens_hsa005900.51937103
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51283658
135Vitamin digestion and absorption_Homo sapiens_hsa049770.51154602
136Protein digestion and absorption_Homo sapiens_hsa049740.50199593
137Phototransduction_Homo sapiens_hsa047440.50137977
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.49964461
139Alzheimers disease_Homo sapiens_hsa050100.49781863
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48648527
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48022833
142Ras signaling pathway_Homo sapiens_hsa040140.46590047
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45553773
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45444244
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44039815
146Insulin signaling pathway_Homo sapiens_hsa049100.40887338
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.40859425
148Tight junction_Homo sapiens_hsa045300.39323999
149Thyroid cancer_Homo sapiens_hsa052160.38955272
150Butanoate metabolism_Homo sapiens_hsa006500.35616318
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.33833619
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32444583
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32024656
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31895152
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.31567009
156Glycerolipid metabolism_Homo sapiens_hsa005610.30480502

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