PLEKHA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardioblast differentiation (GO:0051890)6.02060713
2regulation of gene silencing by RNA (GO:0060966)5.94755312
3regulation of posttranscriptional gene silencing (GO:0060147)5.94755312
4regulation of gene silencing by miRNA (GO:0060964)5.94755312
5pre-miRNA processing (GO:0031054)5.06174879
6regulation of hippo signaling (GO:0035330)4.99595471
7paraxial mesoderm development (GO:0048339)4.62620086
8anterior/posterior axis specification, embryo (GO:0008595)4.33570751
9nuclear pore organization (GO:0006999)4.29344938
10establishment of apical/basal cell polarity (GO:0035089)4.20859260
11trophectodermal cell differentiation (GO:0001829)4.12136787
12axonemal dynein complex assembly (GO:0070286)4.11894717
13nuclear pore complex assembly (GO:0051292)4.09290829
14bundle of His cell to Purkinje myocyte communication (GO:0086069)3.99443239
15histone H4-K12 acetylation (GO:0043983)3.94304093
16vitamin transmembrane transport (GO:0035461)3.91265017
17atrioventricular valve morphogenesis (GO:0003181)3.85753960
18heterochromatin organization (GO:0070828)3.84033562
19regulation of translational fidelity (GO:0006450)3.82898064
20sarcomere organization (GO:0045214)3.74452117
21establishment of monopolar cell polarity (GO:0061162)3.69224399
22establishment or maintenance of monopolar cell polarity (GO:0061339)3.69224399
23regulation of helicase activity (GO:0051095)3.66759211
24positive regulation of SMAD protein import into nucleus (GO:0060391)3.66458591
25negative regulation of histone methylation (GO:0031061)3.65211094
26DNA unwinding involved in DNA replication (GO:0006268)3.63521706
27negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.59666770
28cardiac myofibril assembly (GO:0055003)3.56601516
29IMP biosynthetic process (GO:0006188)3.55276681
30regulation of actin filament-based movement (GO:1903115)3.52627598
31epoxygenase P450 pathway (GO:0019373)3.51599626
32intestinal absorption (GO:0050892)3.49375866
33protein localization to kinetochore (GO:0034501)3.48531962
34intestinal epithelial cell development (GO:0060576)3.48352008
35atrial septum morphogenesis (GO:0060413)3.48197195
36cardiac right ventricle morphogenesis (GO:0003215)3.47680441
37folic acid-containing compound biosynthetic process (GO:0009396)3.46607949
38regulation of histone H3-K9 methylation (GO:0051570)3.46572729
39motile cilium assembly (GO:0044458)3.45452149
40hemidesmosome assembly (GO:0031581)3.40348299
41notochord development (GO:0030903)3.39813854
42embryonic foregut morphogenesis (GO:0048617)3.38819468
43mitotic sister chromatid segregation (GO:0000070)3.36871593
44cilium or flagellum-dependent cell motility (GO:0001539)3.36459353
45DNA duplex unwinding (GO:0032508)3.36415394
46DNA geometric change (GO:0032392)3.36063647
47* epithelial cell-cell adhesion (GO:0090136)3.34665864
48determination of adult lifespan (GO:0008340)3.34253628
49regulation of gene silencing (GO:0060968)3.28299057
50DNA replication-dependent nucleosome assembly (GO:0006335)3.27436763
51DNA replication-dependent nucleosome organization (GO:0034723)3.27436763
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26852166
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.23741219
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23741219
55regulation of the force of heart contraction (GO:0002026)3.18794066
56histone H4-K5 acetylation (GO:0043981)3.18094070
57histone H4-K8 acetylation (GO:0043982)3.18094070
58histone arginine methylation (GO:0034969)3.16416630
59apoptotic process involved in morphogenesis (GO:0060561)3.16124546
60cell communication involved in cardiac conduction (GO:0086065)3.15744959
61regulation of sister chromatid cohesion (GO:0007063)3.14898392
62sister chromatid segregation (GO:0000819)3.14761680
63mitotic nuclear envelope disassembly (GO:0007077)3.14431895
64endocardial cushion development (GO:0003197)3.13624913
65outflow tract septum morphogenesis (GO:0003148)3.12271890
66cilium movement (GO:0003341)3.09898155
67nodal signaling pathway (GO:0038092)3.08950087
68cardiac muscle hypertrophy (GO:0003300)3.08514489
69regulation of cardiac muscle cell contraction (GO:0086004)3.07040977
70desmosome organization (GO:0002934)3.03827202
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03346925
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99081215
73negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.97103712
74membrane disassembly (GO:0030397)2.96584125
75nuclear envelope disassembly (GO:0051081)2.96584125
76myofibril assembly (GO:0030239)2.96032985
77nucleobase biosynthetic process (GO:0046112)2.95636529
78ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.93528912
79ethanol oxidation (GO:0006069)2.93289487
80regulation of telomere maintenance via telomerase (GO:0032210)2.93160455
81peptidyl-arginine omega-N-methylation (GO:0035247)2.92187598
82dosage compensation (GO:0007549)2.91515896
83ethanol metabolic process (GO:0006067)2.91509481
84mitotic chromosome condensation (GO:0007076)2.87463017
85striated muscle hypertrophy (GO:0014897)2.86868594
86primary alcohol catabolic process (GO:0034310)2.86626509
87chromatin assembly (GO:0031497)2.86386516
88flavonoid metabolic process (GO:0009812)2.86323881
89regulation of SMAD protein import into nucleus (GO:0060390)2.85257652
90regulation of translational termination (GO:0006449)2.85009297
91pore complex assembly (GO:0046931)2.84940277
92spliceosomal tri-snRNP complex assembly (GO:0000244)2.84867982
93calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84753696
94cardiac muscle contraction (GO:0060048)2.84475619
95sodium ion homeostasis (GO:0055078)2.83936590
96actomyosin structure organization (GO:0031032)2.83797407
97negative regulation of striated muscle cell apoptotic process (GO:0010664)2.83264803
98lung epithelium development (GO:0060428)2.83172421
99cellular glucuronidation (GO:0052695)2.81844357
100asymmetric protein localization (GO:0008105)2.81322957
101polarized epithelial cell differentiation (GO:0030859)2.81039948
102cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.80243944
103negative regulation of myotube differentiation (GO:0010832)2.78136618
104regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.77663527
105cardiac muscle cell development (GO:0055013)2.77540387
106mitotic metaphase plate congression (GO:0007080)2.77410126
107embryonic process involved in female pregnancy (GO:0060136)2.76385316
108histone H2A monoubiquitination (GO:0035518)2.75115601
109multicellular organismal water homeostasis (GO:0050891)2.74807097
110DNA replication initiation (GO:0006270)2.74168048
111apical protein localization (GO:0045176)2.73406830
112embryonic camera-type eye development (GO:0031076)2.72911723
113hippo signaling (GO:0035329)2.72669739
114IMP metabolic process (GO:0046040)2.72104507
115cardiac muscle tissue morphogenesis (GO:0055008)2.69583211
116regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.68025600
117muscle hypertrophy in response to stress (GO:0003299)2.67696454
118cardiac muscle adaptation (GO:0014887)2.67696454
119cardiac muscle hypertrophy in response to stress (GO:0014898)2.67696454
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.67292779
121glucuronate metabolic process (GO:0019585)2.67193987
122uronic acid metabolic process (GO:0006063)2.67193987
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66854722
124formation of translation preinitiation complex (GO:0001731)2.65305339
125cardiac cell development (GO:0055006)2.65126307
126NADH metabolic process (GO:0006734)2.64757680
127positive regulation of chromosome segregation (GO:0051984)2.64373492
128receptor guanylyl cyclase signaling pathway (GO:0007168)2.63549624
129cell-substrate adherens junction assembly (GO:0007045)2.61274937
130focal adhesion assembly (GO:0048041)2.61274937
131epithelial cilium movement (GO:0003351)2.61186281
132ventricular cardiac muscle cell action potential (GO:0086005)2.60751231
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60172045
134protein localization to chromosome, centromeric region (GO:0071459)2.59740536
135regulation of bile acid biosynthetic process (GO:0070857)2.59660794
136adherens junction assembly (GO:0034333)2.58730081
137left/right pattern formation (GO:0060972)2.58460883
138establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58426663
139embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57918560
140regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.57736248
141toxin metabolic process (GO:0009404)2.57462157
142excretion (GO:0007588)2.57400481
143positive regulation of mitotic sister chromatid separation (GO:1901970)2.57002516
144positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57002516
145positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57002516
146purine nucleobase biosynthetic process (GO:0009113)2.56005894
147cell-substrate junction assembly (GO:0007044)2.55311111
148collecting duct development (GO:0072044)2.54711291
149negative regulation of hormone metabolic process (GO:0032351)2.54022785
150cardiac conduction (GO:0061337)2.52715954
151lateral sprouting from an epithelium (GO:0060601)2.52574796
152negative regulation of keratinocyte proliferation (GO:0010839)2.52269490
153cell communication by electrical coupling (GO:0010644)2.50052687
154peptidyl-arginine N-methylation (GO:0035246)2.49318319
155peptidyl-arginine methylation (GO:0018216)2.49318319
156DNA strand renaturation (GO:0000733)2.48858359
157regulation of transforming growth factor beta2 production (GO:0032909)2.48331174
158branching involved in salivary gland morphogenesis (GO:0060445)2.48220462
159exogenous drug catabolic process (GO:0042738)2.48125108
160DNA conformation change (GO:0071103)2.48065614
161metaphase plate congression (GO:0051310)2.47574103
162negative regulation of mRNA processing (GO:0050686)2.47270611
163glomerulus development (GO:0032835)2.46916321
164auditory receptor cell differentiation (GO:0042491)2.46369848
165ncRNA catabolic process (GO:0034661)2.46217742
166intracellular estrogen receptor signaling pathway (GO:0030520)2.45162351
167cardiac chamber formation (GO:0003207)2.44500115
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.43210072
169gap junction assembly (GO:0016264)2.42400789
170muscle hypertrophy (GO:0014896)2.41872164
171interferon-gamma secretion (GO:0072643)2.41430808
172embryonic axis specification (GO:0000578)2.41295863
173SMAD protein signal transduction (GO:0060395)2.40463190
174drug catabolic process (GO:0042737)2.40144554
175adult heart development (GO:0007512)2.37517108
176negative regulation of protein localization to cell surface (GO:2000009)2.37445602
177angiotensin maturation (GO:0002003)2.35869521
178heart valve morphogenesis (GO:0003179)2.34802545
179establishment of planar polarity (GO:0001736)2.34532790
180establishment of tissue polarity (GO:0007164)2.34532790
181regulation of heart rate (GO:0002027)2.34217613
182regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.34078591
183endocrine process (GO:0050886)2.34078591
184regulation of systemic arterial blood pressure by hormone (GO:0001990)2.34078591
185cardiac muscle cell action potential (GO:0086001)2.33209130
186phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.32739457
187regulation of heart rate by cardiac conduction (GO:0086091)2.31909116
188muscle tissue morphogenesis (GO:0060415)2.31395681
189water homeostasis (GO:0030104)2.28855902
190O-glycan processing (GO:0016266)2.28754383
191negative regulation of hormone biosynthetic process (GO:0032353)2.28002757
192actin filament depolymerization (GO:0030042)2.27541558
193drug metabolic process (GO:0017144)2.26797538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85841985
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.60396947
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.82806286
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.59945137
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.59945137
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.59945137
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.49402081
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.24673870
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.16673455
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.93961685
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.80990641
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.65273465
13TCF3_18692474_ChIP-Seq_MEFs_Mouse2.64624183
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.64520112
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.62719574
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59151411
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.58393837
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.43692006
19* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.43475368
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43401015
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.39941437
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.37560911
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.30099815
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29582592
25* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.29455656
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.22062500
27SOX2_18555785_ChIP-Seq_MESCs_Mouse2.20976688
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.19197185
29EP300_21415370_ChIP-Seq_HL-1_Mouse2.19022154
30STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15507511
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12346074
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10960128
33* GATA4_25053715_ChIP-Seq_YYC3_Human2.08224852
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07243890
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06241714
36ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00160056
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99767642
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.99043557
39* AHR_22903824_ChIP-Seq_MCF-7_Human1.98820603
40* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.93342710
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90328694
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89884259
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87427485
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85975992
45* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85971924
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.85489818
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84161517
48AR_21909140_ChIP-Seq_LNCAP_Human1.83720710
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.82777508
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79105673
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71999647
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.69153392
53NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.69116040
54SOX2_20726797_ChIP-Seq_SW620_Human1.67973436
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.66092503
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.66078523
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65541058
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.63658351
59ZNF263_19887448_ChIP-Seq_K562_Human1.59467196
60* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58472372
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56231046
62* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.55935826
63DROSHA_22980978_ChIP-Seq_HELA_Human1.55683310
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55556255
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55266928
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55075768
67* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53472312
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.50636843
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.50403590
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47930871
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47254113
72* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.47084446
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.43753933
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43375478
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43258485
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42843371
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42734683
78MYC_22102868_ChIP-Seq_BL_Human1.42227732
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.41169783
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40975157
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.39476503
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39339814
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.39081550
84KLF5_25053715_ChIP-Seq_YYC3_Human1.39057256
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36338905
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34452505
87* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.32626006
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.32458771
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30981078
90* SMAD3_21741376_ChIP-Seq_HESCs_Human1.30547058
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29203222
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.28346589
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28245596
94MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26004598
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25533848
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25039108
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23148097
98* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23105129
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.22259100
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21152013
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20609021
102FOXA1_25552417_ChIP-Seq_VCAP_Human1.20479522
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.20030371
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19952578
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.19826468
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.19826468
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18970295
108* NANOG_16518401_ChIP-PET_MESCs_Mouse1.18464253
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15372943
110EZH2_22144423_ChIP-Seq_EOC_Human1.13379019
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13316820
112* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12964266
113* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12563626
114* CTCF_27219007_Chip-Seq_Bcells_Human1.12423441
115* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12413074
116* GATA6_25053715_ChIP-Seq_YYC3_Human1.09315688
117KAP1_27257070_Chip-Seq_ESCs_Mouse1.08890138
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08766005
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08718503
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.07372300
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05547524
122* RACK7_27058665_Chip-Seq_MCF-7_Human1.04785017
123* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04567987
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04218204
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04116651
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03296138
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02091344
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01760648
129VDR_22108803_ChIP-Seq_LS180_Human1.00533041
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99768406
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.99659419
132XRN2_22483619_ChIP-Seq_HELA_Human0.98922185
133* TP63_22573176_ChIP-Seq_HFKS_Human0.98434933
134* ATF3_27146783_Chip-Seq_COLON_Human0.98391656
135* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98387134
136EZH2_27294783_Chip-Seq_ESCs_Mouse0.98061889
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97820748
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97231624
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96603468
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96297162
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95580248
142CHD1_26751641_Chip-Seq_LNCaP_Human0.95471689
143E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95381073
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95152097
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94467031
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.94148066
147* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93866004
148* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92039760
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.91939703
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90898935
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90697736
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.90553970
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90020491
154SMC4_20622854_ChIP-Seq_HELA_Human0.89405462
155CLOCK_20551151_ChIP-Seq_293T_Human0.89071153
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89008258
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88538477
158CDX2_20551321_ChIP-Seq_CACO-2_Human0.87958314
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87012138
160FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86838674
161BCAT_22108803_ChIP-Seq_LS180_Human0.85958453
162EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83510147
163* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83148763
164ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82996546
165TP63_23658742_ChIP-Seq_EP156T_Human0.82513678
166PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82512323
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82405633
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82350538
169CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82255832
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82124361
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82061019
172* ISL1_27105846_Chip-Seq_CPCs_Mouse0.82014106
173CDX2_22108803_ChIP-Seq_LS180_Human0.81505738
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79574562
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.79469069
176EZH2_18974828_ChIP-Seq_MESCs_Mouse0.77932189
177RNF2_18974828_ChIP-Seq_MESCs_Mouse0.77932189
178RNF2_27304074_Chip-Seq_ESCs_Mouse0.77160851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.18447474
2MP0004264_abnormal_extraembryonic_tissu3.18192198
3MP0003941_abnormal_skin_development2.90040112
4MP0005085_abnormal_gallbladder_physiolo2.86475232
5MP0002139_abnormal_hepatobiliary_system2.66805895
6MP0004957_abnormal_blastocyst_morpholog2.63716019
7MP0000537_abnormal_urethra_morphology2.55666688
8MP0003111_abnormal_nucleus_morphology2.54854608
9MP0001666_abnormal_nutrient_absorption2.51377357
10MP0010352_gastrointestinal_tract_polyps2.50537787
11MP0010094_abnormal_chromosome_stability2.42939044
12MP0003693_abnormal_embryo_hatching2.41781545
13MP0003283_abnormal_digestive_organ2.40716916
14MP0004215_abnormal_myocardial_fiber2.40047759
15MP0003123_paternal_imprinting2.32582934
16MP0002653_abnormal_ependyma_morphology2.24935190
17MP0003119_abnormal_digestive_system2.22419508
18MP0008057_abnormal_DNA_replication2.21934001
19MP0010030_abnormal_orbit_morphology2.21191304
20MP0005365_abnormal_bile_salt2.17819946
21MP0003705_abnormal_hypodermis_morpholog2.16598225
22MP0004133_heterotaxia2.16327157
23MP0002837_dystrophic_cardiac_calcinosis2.14715510
24MP0008875_abnormal_xenobiotic_pharmacok2.06831977
25MP0003878_abnormal_ear_physiology2.05331028
26MP0005377_hearing/vestibular/ear_phenot2.05331028
27MP0002084_abnormal_developmental_patter1.98966456
28MP0001849_ear_inflammation1.98081859
29MP0004043_abnormal_pH_regulation1.94332188
30MP0003077_abnormal_cell_cycle1.94193544
31MP0001730_embryonic_growth_arrest1.90229749
32MP0005076_abnormal_cell_differentiation1.84884530
33MP0002796_impaired_skin_barrier1.83382480
34MP0008775_abnormal_heart_ventricle1.83324445
35MP0001672_abnormal_embryogenesis/_devel1.82240906
36MP0005380_embryogenesis_phenotype1.82240906
37MP0002086_abnormal_extraembryonic_tissu1.81275527
38MP0003890_abnormal_embryonic-extraembry1.80227099
39MP0003121_genomic_imprinting1.78725551
40MP0002085_abnormal_embryonic_tissue1.77571934
41MP0001293_anophthalmia1.73362416
42MP0009384_cardiac_valve_regurgitation1.70008660
43MP0003984_embryonic_growth_retardation1.66732657
44MP0004197_abnormal_fetal_growth/weight/1.66637207
45MP0002088_abnormal_embryonic_growth/wei1.65850948
46MP0005330_cardiomyopathy1.65164087
47MP0009053_abnormal_anal_canal1.63883433
48MP0006138_congestive_heart_failure1.63577915
49MP0003567_abnormal_fetal_cardiomyocyte1.61403603
50MP0004036_abnormal_muscle_relaxation1.60579007
51MP0000350_abnormal_cell_proliferation1.59922752
52MP0003566_abnormal_cell_adhesion1.56677744
53MP0002972_abnormal_cardiac_muscle1.54893073
54MP0001697_abnormal_embryo_size1.52654364
55MP0000462_abnormal_digestive_system1.48026456
56MP0005409_darkened_coat_color1.47544569
57MP0000467_abnormal_esophagus_morphology1.45583084
58MP0002254_reproductive_system_inflammat1.40598938
59MP0010678_abnormal_skin_adnexa1.38039215
60MP0009780_abnormal_chondrocyte_physiolo1.38003400
61MP0004084_abnormal_cardiac_muscle1.35784218
62MP0003718_maternal_effect1.32765043
63MP0005367_renal/urinary_system_phenotyp1.32177245
64MP0000516_abnormal_urinary_system1.32177245
65MP0005501_abnormal_skin_physiology1.32077638
66MP0004782_abnormal_surfactant_physiolog1.32038295
67MP0003137_abnormal_impulse_conducting1.28875233
68MP0002080_prenatal_lethality1.26206978
69MP0002098_abnormal_vibrissa_morphology1.26145247
70MP0004272_abnormal_basement_membrane1.24949248
71MP0002697_abnormal_eye_size1.24149357
72MP0004085_abnormal_heartbeat1.23845294
73MP0000751_myopathy1.23756099
74MP0008058_abnormal_DNA_repair1.22650371
75MP0002111_abnormal_tail_morphology1.21696006
76MP0002876_abnormal_thyroid_physiology1.20469626
77MP0002249_abnormal_larynx_morphology1.20160581
78MP0001765_abnormal_ion_homeostasis1.19275319
79MP0003122_maternal_imprinting1.18854916
80MP0008007_abnormal_cellular_replicative1.17870731
81MP0000566_synostosis1.16013614
82MP0001664_abnormal_digestion1.14921583
83MP0003453_abnormal_keratinocyte_physiol1.14480139
84MP0004233_abnormal_muscle_weight1.14354218
85MP0009379_abnormal_foot_pigmentation1.13431549
86MP0010329_abnormal_lipoprotein_level1.13258609
87MP0008932_abnormal_embryonic_tissue1.13055257
88MP0000762_abnormal_tongue_morphology1.12756134
89MP0005623_abnormal_meninges_morphology1.11820914
90MP0000383_abnormal_hair_follicle1.10927139
91MP0010368_abnormal_lymphatic_system1.10523783
92MP0005670_abnormal_white_adipose1.10081614
93MP0002909_abnormal_adrenal_gland1.09921727
94MP0009643_abnormal_urine_homeostasis1.09704653
95MP0001485_abnormal_pinna_reflex1.08122669
96MP0005394_taste/olfaction_phenotype1.05661313
97MP0005499_abnormal_olfactory_system1.05661313
98MP0003115_abnormal_respiratory_system1.05481461
99MP0000579_abnormal_nail_morphology1.02996384
100MP0001286_abnormal_eye_development1.02910085
101MP0009840_abnormal_foam_cell1.02850328
102MP0001544_abnormal_cardiovascular_syste1.00800067
103MP0005385_cardiovascular_system_phenoty1.00800067
104MP0004885_abnormal_endolymph1.00643811
105MP0003942_abnormal_urinary_system1.00449877
106MP0002089_abnormal_postnatal_growth/wei0.99281997
107MP0003937_abnormal_limbs/digits/tail_de0.98826928
108MP0000534_abnormal_ureter_morphology0.98405416
109MP0004019_abnormal_vitamin_homeostasis0.98040268
110MP0000428_abnormal_craniofacial_morphol0.97875772
111MP0002234_abnormal_pharynx_morphology0.96359835
112MP0003861_abnormal_nervous_system0.95768212
113MP0005408_hypopigmentation0.95720572
114MP0001346_abnormal_lacrimal_gland0.95711943
115MP0002092_abnormal_eye_morphology0.95404106
116MP0000432_abnormal_head_morphology0.95204424
117MP0003787_abnormal_imprinting0.95083848
118MP0002127_abnormal_cardiovascular_syste0.94843767
119MP0003136_yellow_coat_color0.93924160
120MP0002822_catalepsy0.93295740
121MP0000427_abnormal_hair_cycle0.92485196
122MP0005620_abnormal_muscle_contractility0.92479547
123MP0005395_other_phenotype0.92186992
124MP0003806_abnormal_nucleotide_metabolis0.92104826
125MP0003935_abnormal_craniofacial_develop0.91505068
126MP0010307_abnormal_tumor_latency0.91443996
127MP0005332_abnormal_amino_acid0.91101145
128MP0008877_abnormal_DNA_methylation0.90975445
129MP0005023_abnormal_wound_healing0.87128170
130MP0005360_urolithiasis0.86794675
131MP0004087_abnormal_muscle_fiber0.86591527
132MP0000678_abnormal_parathyroid_gland0.86280249
133MP0008789_abnormal_olfactory_epithelium0.86096354
134MP0002925_abnormal_cardiovascular_devel0.85997988
135MP0009703_decreased_birth_body0.84777996
136MP0002138_abnormal_hepatobiliary_system0.82575971
137MP0010630_abnormal_cardiac_muscle0.81217617
138MP0003315_abnormal_perineum_morphology0.80595845
139MP0002233_abnormal_nose_morphology0.80415950
140MP0003252_abnormal_bile_duct0.79837232
141MP0005248_abnormal_Harderian_gland0.79005045
142MP0003183_abnormal_peptide_metabolism0.78551199
143MP0006292_abnormal_olfactory_placode0.78368759
144MP0003755_abnormal_palate_morphology0.78317948
145MP0005666_abnormal_adipose_tissue0.76613904
146MP0005636_abnormal_mineral_homeostasis0.76127725
147MP0000538_abnormal_urinary_bladder0.75953894
148MP0003868_abnormal_feces_composition0.75922552
149MP0004858_abnormal_nervous_system0.75911481
150MP0001756_abnormal_urination0.73990888
151MP0009672_abnormal_birth_weight0.73551222
152MP0001661_extended_life_span0.72981685
153MP0000477_abnormal_intestine_morphology0.72670540
154MP0004484_altered_response_of0.70476259
155MP0000026_abnormal_inner_ear0.68291071
156MP0003938_abnormal_ear_development0.68036833

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.85067996
2Hyperactive renin-angiotensin system (HP:0000841)4.68360343
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56419191
4Right ventricular cardiomyopathy (HP:0011663)3.75720076
5Chronic bronchitis (HP:0004469)3.64647492
6Astrocytoma (HP:0009592)3.54767701
7Abnormality of the astrocytes (HP:0100707)3.54767701
8Abnormal respiratory motile cilium physiology (HP:0012261)3.50982909
9Abnormality of the labia minora (HP:0012880)3.46624799
10Sudden death (HP:0001699)3.43564083
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43097958
12Syncope (HP:0001279)3.42364753
13Rhinitis (HP:0012384)3.41365840
14Decreased circulating renin level (HP:0003351)3.39893528
15Selective tooth agenesis (HP:0001592)3.39055323
16Abnormal ciliary motility (HP:0012262)3.34333509
17Abnormal respiratory epithelium morphology (HP:0012253)3.25212845
18Abnormal respiratory motile cilium morphology (HP:0005938)3.25212845
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.21279521
20Absent/shortened dynein arms (HP:0200106)3.21279521
21Esophageal atresia (HP:0002032)3.19516661
22Flat acetabular roof (HP:0003180)3.13770406
23Bundle branch block (HP:0011710)3.12292032
24Atrial fibrillation (HP:0005110)3.07186816
25Abnormality of renin-angiotensin system (HP:0000847)3.01902285
26Glioma (HP:0009733)2.84073892
27Shawl scrotum (HP:0000049)2.83713858
28Medulloblastoma (HP:0002885)2.80835846
29Hyperaldosteronism (HP:0000859)2.77284003
30Rib fusion (HP:0000902)2.76062354
31Malnutrition (HP:0004395)2.75630961
32Colon cancer (HP:0003003)2.75538807
33Biliary tract neoplasm (HP:0100574)2.73131053
34Short humerus (HP:0005792)2.68625759
35Abnormal number of incisors (HP:0011064)2.68503020
36Milia (HP:0001056)2.68034082
37Abnormality of proline metabolism (HP:0010907)2.67020542
38Hydroxyprolinuria (HP:0003080)2.67020542
39Abnormal ventriculo-arterial connection (HP:0011563)2.64263207
40Transposition of the great arteries (HP:0001669)2.64263207
41Abnormal connection of the cardiac segments (HP:0011545)2.64263207
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63165036
43Neoplasm of the oral cavity (HP:0100649)2.62605928
44Pseudobulbar signs (HP:0002200)2.59056602
45Missing ribs (HP:0000921)2.57588739
46Primary atrial arrhythmia (HP:0001692)2.57066465
47Supernumerary spleens (HP:0009799)2.56082107
48Aplasia/hypoplasia of the humerus (HP:0006507)2.55387886
49Abnormality of chloride homeostasis (HP:0011422)2.55244489
50Rhabdomyosarcoma (HP:0002859)2.54216109
51Focal segmental glomerulosclerosis (HP:0000097)2.54118359
52Bilateral microphthalmos (HP:0007633)2.44909204
53Bronchomalacia (HP:0002780)2.42900339
54Neoplasm of striated muscle (HP:0009728)2.39923950
55Supraventricular tachycardia (HP:0004755)2.38683685
56Gonadal dysgenesis (HP:0000133)2.38282694
57Abnormality of the salivary glands (HP:0010286)2.37701079
58Gastrointestinal atresia (HP:0002589)2.37604665
59Pili torti (HP:0003777)2.36173559
60Absent radius (HP:0003974)2.34740906
61Bronchiectasis (HP:0002110)2.32484982
62Skull defect (HP:0001362)2.32018589
63Supraventricular arrhythmia (HP:0005115)2.31567258
64Congenital malformation of the right heart (HP:0011723)2.30798645
65Double outlet right ventricle (HP:0001719)2.30798645
66Anophthalmia (HP:0000528)2.28080206
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.28062832
68Anal stenosis (HP:0002025)2.24203051
69Tubular atrophy (HP:0000092)2.23057281
70Testicular neoplasm (HP:0010788)2.22935047
71Malignant gastrointestinal tract tumors (HP:0006749)2.22749275
72Gastrointestinal carcinoma (HP:0002672)2.22749275
73Ventricular arrhythmia (HP:0004308)2.22636984
74Absent forearm bone (HP:0003953)2.21852462
75Aplasia involving forearm bones (HP:0009822)2.21852462
76Hypoplastic left heart (HP:0004383)2.21426282
77Lipoatrophy (HP:0100578)2.19341148
78Urethral obstruction (HP:0000796)2.19073180
79Abnormality of the lower motor neuron (HP:0002366)2.16188624
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15783844
81Dilated cardiomyopathy (HP:0001644)2.14089899
82Proximal tubulopathy (HP:0000114)2.12811311
83Partial duplication of thumb phalanx (HP:0009944)2.11336399
84Glomerulosclerosis (HP:0000096)2.08724239
85High anterior hairline (HP:0009890)2.07911639
86Abnormal tarsal ossification (HP:0008369)2.06725772
87Chromsome breakage (HP:0040012)2.04756779
88Short 1st metacarpal (HP:0010034)2.04178517
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.04178517
90Intrahepatic cholestasis (HP:0001406)2.03228986
91Abnormal biliary tract morphology (HP:0012440)2.00187225
92Short phalanx of the thumb (HP:0009660)1.98720208
93Metaphyseal cupping (HP:0003021)1.97667632
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.96994586
95Hypercalciuria (HP:0002150)1.96569469
96Abnormality of the aortic arch (HP:0012303)1.96284645
97Renal duplication (HP:0000075)1.94118508
98Impulsivity (HP:0100710)1.93845016
99Abnormal pancreas size (HP:0012094)1.93066531
100Vertebral clefting (HP:0008428)1.92347916
101Germ cell neoplasia (HP:0100728)1.90919852
102Abnormality of the 1st metacarpal (HP:0010009)1.89593235
103Hyperkalemia (HP:0002153)1.89336577
104Heart block (HP:0012722)1.88970119
105Hypoplastic labia majora (HP:0000059)1.88907506
106Nasal polyposis (HP:0100582)1.88836074
107Palpitations (HP:0001962)1.87860020
108Abdominal situs inversus (HP:0003363)1.86308453
109Abnormality of abdominal situs (HP:0011620)1.86308453
110Ovarian neoplasm (HP:0100615)1.86223827
111Uterine neoplasm (HP:0010784)1.85554473
112Abnormality of the dental root (HP:0006486)1.85537250
113Taurodontia (HP:0000679)1.85537250
114Abnormality of permanent molar morphology (HP:0011071)1.85537250
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.84955190
116Deviation of the thumb (HP:0009603)1.84512077
117Abnormality of the antihelix (HP:0009738)1.84201378
118Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84100299
119Abnormal atrioventricular conduction (HP:0005150)1.83068878
120Skin pits (HP:0100276)1.82344912
121Intestinal fistula (HP:0100819)1.81901036
122Rectal fistula (HP:0100590)1.81161995
123Rectovaginal fistula (HP:0000143)1.81161995
124Abnormality of the diencephalon (HP:0010662)1.80709784
125Delayed epiphyseal ossification (HP:0002663)1.80586937
126Facial cleft (HP:0002006)1.79626439
127Widely patent fontanelles and sutures (HP:0004492)1.78011428
128Increased nuchal translucency (HP:0010880)1.77713873
129Metabolic alkalosis (HP:0200114)1.76472933
130Abnormality of glycine metabolism (HP:0010895)1.75649648
131Abnormality of serine family amino acid metabolism (HP:0010894)1.75649648
132Bicornuate uterus (HP:0000813)1.75071334
133Infertility (HP:0000789)1.74975859
134Proximal placement of thumb (HP:0009623)1.74864460
135Ventricular tachycardia (HP:0004756)1.74498599
136Abnormality of carpal bone ossification (HP:0006257)1.74340072
137Fat malabsorption (HP:0002630)1.73454040
138Alkalosis (HP:0001948)1.73351240
139Supernumerary ribs (HP:0005815)1.73215711
140Vertebral fusion (HP:0002948)1.72983238
141Abdominal distention (HP:0003270)1.72683766
142Deep venous thrombosis (HP:0002625)1.72386185
143Male infertility (HP:0003251)1.72058506
144Adenoma sebaceum (HP:0009720)1.71962555
145Angiofibromas (HP:0010615)1.71962555
146Breast hypoplasia (HP:0003187)1.71413881
147Hemorrhage of the eye (HP:0011885)1.70374661
148Abnormality of cochlea (HP:0000375)1.69607376
149Sparse scalp hair (HP:0002209)1.68842978
150True hermaphroditism (HP:0010459)1.68277079
151Hyperglycinuria (HP:0003108)1.67360994
152Abnormality of the dental pulp (HP:0006479)1.67122564
153Bifid scrotum (HP:0000048)1.67026135
154Visceral angiomatosis (HP:0100761)1.66860854
155Osteomalacia (HP:0002749)1.66841246
156Pigmentary retinal degeneration (HP:0001146)1.66513043
157Abnormality of the labia majora (HP:0012881)1.65888807
158Occipital encephalocele (HP:0002085)1.64402302
159Agnosia (HP:0010524)1.64318620
160Hemivertebrae (HP:0002937)1.64208605
161Basal cell carcinoma (HP:0002671)1.63786736
162Woolly hair (HP:0002224)1.63373853
163Hepatoblastoma (HP:0002884)1.63071867
164Broad thumb (HP:0011304)1.62992315
165Renal salt wasting (HP:0000127)1.62724611
166Supernumerary bones of the axial skeleton (HP:0009144)1.62323149
167Chronic hepatic failure (HP:0100626)1.62253303
168Hyperacusis (HP:0010780)1.62124369
169Hypobetalipoproteinemia (HP:0003563)1.61862814
170Preauricular pit (HP:0004467)1.61838158
171Periauricular skin pits (HP:0100277)1.61838158
172Skin tags (HP:0010609)1.61672352
173Flattened epiphyses (HP:0003071)1.61427009
174Abnormality of molar (HP:0011077)1.61360572
175Abnormality of molar morphology (HP:0011070)1.61360572
176Late onset (HP:0003584)1.60984763
177Preauricular skin tag (HP:0000384)1.60756439
178Lymphangioma (HP:0100764)1.59500929
179Neonatal short-limb short stature (HP:0008921)1.59357152
180Vaginal fistula (HP:0004320)1.59342104
181Elfin facies (HP:0004428)1.59264584
182Nail dystrophy (HP:0008404)1.59233954
183Abnormality of the pubic bones (HP:0003172)1.59017699
184Abnormality of potassium homeostasis (HP:0011042)1.58898991
185Maternal diabetes (HP:0009800)1.58853283
186Patellar aplasia (HP:0006443)1.58779318
187Vertebral hypoplasia (HP:0008417)1.57013758
188Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.57013758
189Spinal muscular atrophy (HP:0007269)1.54354954
190Lip pit (HP:0100267)1.52867880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.81055831
2EPHA24.66098447
3CDK124.53911360
4TTK2.79314440
5STK392.77817143
6RPS6KB22.69030315
7NEK12.61048205
8PIK3CA2.55061934
9CDC72.48509938
10EEF2K2.45474396
11MAP3K102.27755830
12AKT32.21006653
13BRD41.98786618
14LATS11.98039202
15PKN21.95941401
16TRIB31.95566685
17ACVR1B1.86697217
18STK38L1.84473410
19NEK21.81430317
20TSSK61.80373297
21ICK1.79647129
22MYLK1.77700137
23LMTK21.75728208
24WEE11.62215891
25RIPK11.54937637
26CDK71.53465193
27WNK31.49145921
28OXSR11.47239096
29STK101.46648435
30MST41.42702450
31FGFR41.42337904
32PAK41.38917228
33SIK11.37317763
34PRKCI1.33588059
35TNIK1.32768335
36MTOR1.32199318
37LATS21.32106848
38PLK11.29338530
39CAMK1G1.28506972
40CDK41.26089756
41ALK1.20213005
42MAPKAPK31.19812570
43CDK81.19392459
44PTK61.18929152
45MAP3K81.16911423
46PASK1.12327255
47TYRO31.11759224
48CHEK11.10133548
49AURKB1.08906715
50GRK61.07306938
51CDK61.04666479
52FGFR11.03543622
53MET1.03536695
54MAP3K91.03498729
55PRKAA21.03291906
56ATR1.01756112
57CDC42BPA1.01404329
58BMPR1B1.00576053
59CHEK20.99537156
60CASK0.99480921
61AKT20.98741090
62PTK20.98653494
63CAMK1D0.96238813
64FGFR20.94405644
65EPHB10.91810634
66PLK30.89048705
67FER0.88667622
68DDR20.87557554
69CDK20.87512883
70ERN10.86408867
71PDGFRA0.83558974
72SCYL20.83542906
73STK380.83430246
74ATM0.81025537
75WNK40.80945499
76FGFR30.80880500
77STK30.80701321
78CAMK2D0.80380563
79EPHA40.79123667
80ZAK0.78898769
81SRPK10.78390079
82NME10.76760699
83CSNK1E0.75835474
84CDK90.75565060
85MAPK150.75284276
86BMX0.74919172
87EPHB20.72754339
88BCR0.71849627
89BRSK20.70795186
90AURKA0.70070382
91PDK40.69345273
92PDK30.69345273
93ERBB20.67748800
94MAP3K20.66958332
95PRKAA10.65802199
96PAK20.64471393
97MAP3K70.63337203
98INSRR0.63312352
99BUB10.63010920
100MAPKAPK50.60131778
101CDK10.60109034
102NLK0.59573046
103PRKD30.58928567
104CSNK1D0.58240339
105STK40.56038823
106PNCK0.55619952
107MUSK0.55525832
108PRKCE0.54561924
109WNK10.54233506
110TRPM70.54073747
111KSR10.51699191
112ROCK10.51357928
113MAPK140.50312778
114PDK20.49830393
115EPHA30.49693115
116MAP2K20.49631442
117PRKDC0.47844300
118RPS6KA20.47635502
119MELK0.47493838
120RET0.47141100
121NEK90.46866449
122PRKG20.46637468
123MAP3K60.45860020
124GSK3B0.45294160
125SGK2230.45036761
126SGK4940.45036761
127PRKCZ0.44154387
128FLT30.43702274
129STK240.43638523
130NEK60.43198136
131ERBB40.41215574
132AKT10.40276111
133DMPK0.38900320
134OBSCN0.38789492
135MAPK10.38765977
136RPS6KA10.38745051
137SMG10.37109990
138UHMK10.37006271
139CAMK2G0.36627027
140PIM10.36071733
141CAMK2B0.35150735
142CAMK10.35023422
143MKNK20.34844589
144YES10.34430358
145CSNK2A20.34086032
146MAP3K30.33577737
147DYRK1B0.33035381
148MATK0.32909105
149CAMK2A0.32696659
150PDPK10.31631149
151ILK0.30429064
152CAMK40.29994944
153PRKD10.28471261
154RPS6KA60.26572100
155SGK20.25993960
156PRKACG0.25478778

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.22608421
2Histidine metabolism_Homo sapiens_hsa003402.83610979
3One carbon pool by folate_Homo sapiens_hsa006702.68065677
4DNA replication_Homo sapiens_hsa030302.50890477
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47378667
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40804907
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38767672
8Basal cell carcinoma_Homo sapiens_hsa052172.37469140
9Hippo signaling pathway_Homo sapiens_hsa043902.30328938
10RNA transport_Homo sapiens_hsa030132.27947805
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.12592917
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10410875
13mRNA surveillance pathway_Homo sapiens_hsa030152.09994606
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07188870
15Chemical carcinogenesis_Homo sapiens_hsa052042.01235892
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.98208730
17Spliceosome_Homo sapiens_hsa030401.97136975
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92672150
19Retinol metabolism_Homo sapiens_hsa008301.90623787
20Caffeine metabolism_Homo sapiens_hsa002321.89996121
21Lysine degradation_Homo sapiens_hsa003101.89726461
22Tight junction_Homo sapiens_hsa045301.86060294
23Fatty acid degradation_Homo sapiens_hsa000711.82478429
24Adherens junction_Homo sapiens_hsa045201.80010316
25Cell cycle_Homo sapiens_hsa041101.78411800
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.78263878
27PPAR signaling pathway_Homo sapiens_hsa033201.77543692
28Hedgehog signaling pathway_Homo sapiens_hsa043401.66706549
29Linoleic acid metabolism_Homo sapiens_hsa005911.63855757
30Biosynthesis of amino acids_Homo sapiens_hsa012301.63684851
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62619595
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52219181
33Tyrosine metabolism_Homo sapiens_hsa003501.51617058
34Tryptophan metabolism_Homo sapiens_hsa003801.50386769
35Base excision repair_Homo sapiens_hsa034101.48446844
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46457664
37Notch signaling pathway_Homo sapiens_hsa043301.45298737
38Fructose and mannose metabolism_Homo sapiens_hsa000511.42399709
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37168608
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34188062
41Fanconi anemia pathway_Homo sapiens_hsa034601.32909699
42Thyroid cancer_Homo sapiens_hsa052161.26105426
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25254827
44Galactose metabolism_Homo sapiens_hsa000521.22707361
45Carbon metabolism_Homo sapiens_hsa012001.22217946
46Propanoate metabolism_Homo sapiens_hsa006401.20457327
47Protein digestion and absorption_Homo sapiens_hsa049741.18902374
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18204569
49Homologous recombination_Homo sapiens_hsa034401.17051454
50Bladder cancer_Homo sapiens_hsa052191.15800133
51Fat digestion and absorption_Homo sapiens_hsa049751.14617655
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14304612
53Nucleotide excision repair_Homo sapiens_hsa034201.14216110
54MicroRNAs in cancer_Homo sapiens_hsa052061.11604580
55Mineral absorption_Homo sapiens_hsa049781.10140395
56p53 signaling pathway_Homo sapiens_hsa041151.09124030
57Glycerolipid metabolism_Homo sapiens_hsa005611.08465425
58Wnt signaling pathway_Homo sapiens_hsa043101.07190324
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.06632254
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06424198
61Ovarian steroidogenesis_Homo sapiens_hsa049131.06207262
62Cardiac muscle contraction_Homo sapiens_hsa042601.05675137
63Butanoate metabolism_Homo sapiens_hsa006501.05394547
64beta-Alanine metabolism_Homo sapiens_hsa004101.04777453
65Fatty acid metabolism_Homo sapiens_hsa012121.01873241
66Nitrogen metabolism_Homo sapiens_hsa009101.01499063
67TGF-beta signaling pathway_Homo sapiens_hsa043501.01358279
68Endometrial cancer_Homo sapiens_hsa052130.99823054
69ABC transporters_Homo sapiens_hsa020100.99760571
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99016398
71Vitamin digestion and absorption_Homo sapiens_hsa049770.98734527
72RNA degradation_Homo sapiens_hsa030180.98294400
73Small cell lung cancer_Homo sapiens_hsa052220.98015550
74Sulfur metabolism_Homo sapiens_hsa009200.95022934
75mTOR signaling pathway_Homo sapiens_hsa041500.94057745
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.93884573
77Complement and coagulation cascades_Homo sapiens_hsa046100.92577695
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92211998
79Bile secretion_Homo sapiens_hsa049760.92083054
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91985553
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87058235
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86131897
83Selenocompound metabolism_Homo sapiens_hsa004500.82397720
84Non-homologous end-joining_Homo sapiens_hsa034500.82174866
85Peroxisome_Homo sapiens_hsa041460.81672277
86Arachidonic acid metabolism_Homo sapiens_hsa005900.81068205
87Thyroid hormone synthesis_Homo sapiens_hsa049180.79986294
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79511482
89Oocyte meiosis_Homo sapiens_hsa041140.79442469
90Pancreatic secretion_Homo sapiens_hsa049720.78864483
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78047115
92Colorectal cancer_Homo sapiens_hsa052100.77599442
93Sulfur relay system_Homo sapiens_hsa041220.73138218
94Proteoglycans in cancer_Homo sapiens_hsa052050.72706739
95Sphingolipid metabolism_Homo sapiens_hsa006000.71643578
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70371289
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70242775
98Renin-angiotensin system_Homo sapiens_hsa046140.69571857
99Dorso-ventral axis formation_Homo sapiens_hsa043200.69179380
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68697701
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67267057
102Pathways in cancer_Homo sapiens_hsa052000.67153072
103Melanogenesis_Homo sapiens_hsa049160.66762515
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65912700
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65407264
106Viral carcinogenesis_Homo sapiens_hsa052030.63534801
107ECM-receptor interaction_Homo sapiens_hsa045120.62753698
108Starch and sucrose metabolism_Homo sapiens_hsa005000.61694653
109Insulin resistance_Homo sapiens_hsa049310.61502647
110HTLV-I infection_Homo sapiens_hsa051660.61445917
111Glutathione metabolism_Homo sapiens_hsa004800.61250826
112Dilated cardiomyopathy_Homo sapiens_hsa054140.59894410
113Arginine and proline metabolism_Homo sapiens_hsa003300.58761407
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58014995
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57597306
116Glucagon signaling pathway_Homo sapiens_hsa049220.57402557
117Arginine biosynthesis_Homo sapiens_hsa002200.55671184
118Ether lipid metabolism_Homo sapiens_hsa005650.55500936
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.54903960
120Systemic lupus erythematosus_Homo sapiens_hsa053220.54858961
121Focal adhesion_Homo sapiens_hsa045100.54498136
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54411559
123Steroid biosynthesis_Homo sapiens_hsa001000.52492100
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.52299674
125Circadian rhythm_Homo sapiens_hsa047100.52295662
126Cocaine addiction_Homo sapiens_hsa050300.48101233
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47525093
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47307453
129Pyrimidine metabolism_Homo sapiens_hsa002400.46121748
130HIF-1 signaling pathway_Homo sapiens_hsa040660.45459173
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44201955
132Phenylalanine metabolism_Homo sapiens_hsa003600.43983676
133Fatty acid biosynthesis_Homo sapiens_hsa000610.43214904
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42684505
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.42536217
136Inositol phosphate metabolism_Homo sapiens_hsa005620.41806914
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41160260
138Axon guidance_Homo sapiens_hsa043600.41042231
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40355120
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.39808442
141Insulin secretion_Homo sapiens_hsa049110.39617967
142Pyruvate metabolism_Homo sapiens_hsa006200.39298817
143ErbB signaling pathway_Homo sapiens_hsa040120.38691429
144AMPK signaling pathway_Homo sapiens_hsa041520.37466507
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36830974
146Estrogen signaling pathway_Homo sapiens_hsa049150.34875664
147Folate biosynthesis_Homo sapiens_hsa007900.34598466
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33523416
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33399398

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