PLEKHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)7.21610813
2sodium ion export (GO:0071436)6.86203020
3thyroid hormone generation (GO:0006590)6.43603632
4response to pheromone (GO:0019236)6.16866456
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.14475427
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.66360276
7cerebellar Purkinje cell differentiation (GO:0021702)5.64599763
8behavioral response to nicotine (GO:0035095)5.40378555
9cell communication by electrical coupling (GO:0010644)5.34476500
10synaptic vesicle maturation (GO:0016188)5.32258399
11neuronal action potential propagation (GO:0019227)5.16447906
12thyroid hormone metabolic process (GO:0042403)5.12486062
13neurofilament cytoskeleton organization (GO:0060052)5.05134942
14potassium ion homeostasis (GO:0055075)5.05048724
15synaptic vesicle exocytosis (GO:0016079)4.95172738
16regulation of synaptic vesicle exocytosis (GO:2000300)4.77995604
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73029130
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.72519160
19cellular sodium ion homeostasis (GO:0006883)4.65053486
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58131110
21cerebellar granule cell differentiation (GO:0021707)4.57406637
22positive regulation of synapse maturation (GO:0090129)4.45654625
23detection of light stimulus involved in visual perception (GO:0050908)4.38709953
24detection of light stimulus involved in sensory perception (GO:0050962)4.38709953
25relaxation of smooth muscle (GO:0044557)4.37270406
26membrane depolarization during action potential (GO:0086010)4.36148387
27membrane repolarization (GO:0086009)4.36012337
28vocalization behavior (GO:0071625)4.33910235
29nonmotile primary cilium assembly (GO:0035058)4.29560708
30glutamate secretion (GO:0014047)4.27571931
31neurotransmitter secretion (GO:0007269)4.27264680
32L-fucose catabolic process (GO:0042355)4.20662515
33fucose catabolic process (GO:0019317)4.20662515
34L-fucose metabolic process (GO:0042354)4.20662515
35detection of temperature stimulus (GO:0016048)4.18733727
36neuromuscular process controlling posture (GO:0050884)4.14077271
37glutamate receptor signaling pathway (GO:0007215)4.12773516
38potassium ion import (GO:0010107)4.12769173
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12172738
40locomotory exploration behavior (GO:0035641)4.09622461
41cell differentiation in hindbrain (GO:0021533)4.08974157
42positive regulation of potassium ion transmembrane transport (GO:1901381)4.07634335
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.04949073
44gamma-aminobutyric acid signaling pathway (GO:0007214)4.02378366
45synaptic vesicle endocytosis (GO:0048488)3.97764242
46detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.94256803
47detection of temperature stimulus involved in sensory perception (GO:0050961)3.94256803
48indolalkylamine metabolic process (GO:0006586)3.92941559
49regulation of synaptic vesicle transport (GO:1902803)3.89993001
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88632330
51cell communication involved in cardiac conduction (GO:0086065)3.86619932
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.82840299
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.80421888
54cellular ketone body metabolic process (GO:0046950)3.79619217
55innervation (GO:0060384)3.78444284
56synaptic transmission, glutamatergic (GO:0035249)3.74633070
57sodium ion homeostasis (GO:0055078)3.74332634
58epithelial cilium movement (GO:0003351)3.74033892
59mating behavior (GO:0007617)3.68804288
60protein polyglutamylation (GO:0018095)3.67892856
61membrane repolarization during action potential (GO:0086011)3.66026752
62positive regulation of potassium ion transport (GO:0043268)3.62505823
63axon cargo transport (GO:0008088)3.62449786
64neurotransmitter transport (GO:0006836)3.62107065
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.59534771
66gamma-aminobutyric acid transport (GO:0015812)3.58582767
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57903639
68platelet dense granule organization (GO:0060155)3.57014285
69neuron-neuron synaptic transmission (GO:0007270)3.55893406
70regulation of synapse maturation (GO:0090128)3.55415775
71indole-containing compound catabolic process (GO:0042436)3.52112112
72indolalkylamine catabolic process (GO:0046218)3.52112112
73tryptophan catabolic process (GO:0006569)3.52112112
74synapse assembly (GO:0007416)3.47808552
75cornea development in camera-type eye (GO:0061303)3.44817490
76kynurenine metabolic process (GO:0070189)3.43646130
77ketone body metabolic process (GO:1902224)3.40145352
78negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38854202
79axoneme assembly (GO:0035082)3.37205310
80relaxation of muscle (GO:0090075)3.36579322
81layer formation in cerebral cortex (GO:0021819)3.35561082
82tryptophan metabolic process (GO:0006568)3.35022946
83water-soluble vitamin biosynthetic process (GO:0042364)3.34437367
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33904764
85negative regulation of hormone metabolic process (GO:0032351)3.29144162
86negative regulation of hormone biosynthetic process (GO:0032353)3.29144162
87membrane hyperpolarization (GO:0060081)3.28134392
88retinal cone cell development (GO:0046549)3.26979927
89transmission of nerve impulse (GO:0019226)3.24387091
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.23700403
91negative regulation of dendrite morphogenesis (GO:0050774)3.23584359
92sodium ion transmembrane transport (GO:0035725)3.23169042
93regulation of cilium movement (GO:0003352)3.22152072
94cell migration in hindbrain (GO:0021535)3.21988770
95protein localization to synapse (GO:0035418)3.21967416
96neuromuscular synaptic transmission (GO:0007274)3.20281176
97regulation of voltage-gated calcium channel activity (GO:1901385)3.16420357
98cellular potassium ion transport (GO:0071804)3.16075325
99potassium ion transmembrane transport (GO:0071805)3.16075325
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16059408
101regulation of neurotransmitter secretion (GO:0046928)3.15658386
102synaptic vesicle docking involved in exocytosis (GO:0016081)3.14525020
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.12888974
104cilium movement (GO:0003341)3.12807803
105indole-containing compound metabolic process (GO:0042430)3.12432437
106primary amino compound metabolic process (GO:1901160)3.11696911
107regulation of neurotransmitter levels (GO:0001505)3.10741361
108negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09124420
109protein localization to cilium (GO:0061512)3.06748980
110neuromuscular process controlling balance (GO:0050885)3.06236480
111photoreceptor cell maintenance (GO:0045494)3.05706687
112piRNA metabolic process (GO:0034587)3.05406986
113relaxation of cardiac muscle (GO:0055119)3.02899452
114adult walking behavior (GO:0007628)3.02475176
115neural tube formation (GO:0001841)3.01997079
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01020702
117mitochondrial respiratory chain complex I assembly (GO:0032981)3.01020702
118NADH dehydrogenase complex assembly (GO:0010257)3.01020702
119reflex (GO:0060004)3.00456038
120cilium morphogenesis (GO:0060271)2.99465695
121neuronal action potential (GO:0019228)2.98795417
122negative regulation of microtubule polymerization (GO:0031115)2.98196354
123response to nitrosative stress (GO:0051409)2.95368817
124regulation of neurotransmitter transport (GO:0051588)2.93961491
125cilium or flagellum-dependent cell motility (GO:0001539)2.93584159
126regulation of membrane repolarization (GO:0060306)2.93452333
127long term synaptic depression (GO:0060292)2.92510069
128potassium ion transport (GO:0006813)2.92489898
129cilium organization (GO:0044782)2.92461162
130protein complex biogenesis (GO:0070271)2.91361301
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90641906
132positive regulation of sodium ion transport (GO:0010765)2.88684630
133DNA deamination (GO:0045006)2.88582246
134regulation of vesicle fusion (GO:0031338)2.88232773
135cilium assembly (GO:0042384)2.87262898
136somite development (GO:0061053)2.86955654
137behavioral response to ethanol (GO:0048149)2.86660718
138regulation of potassium ion transmembrane transport (GO:1901379)2.85676517
139membrane depolarization (GO:0051899)2.84879803
140negative regulation of telomere maintenance (GO:0032205)2.84498789
141serotonin metabolic process (GO:0042428)2.83661059
142synaptic transmission (GO:0007268)2.83533623
143photoreceptor cell development (GO:0042461)2.83391290
144auditory receptor cell stereocilium organization (GO:0060088)2.82722726
145synaptic transmission, cholinergic (GO:0007271)2.80495723
146long-term memory (GO:0007616)2.80008885
147response to parathyroid hormone (GO:0071107)2.79607142
148preassembly of GPI anchor in ER membrane (GO:0016254)2.78867078
149regulation of heart rate by cardiac conduction (GO:0086091)2.77837349
150ubiquinone biosynthetic process (GO:0006744)2.77496384
151dopamine transport (GO:0015872)2.77051256
152intraciliary transport (GO:0042073)2.76963200
153mitochondrial respiratory chain complex assembly (GO:0033108)2.69675438
154multicellular organism reproduction (GO:0032504)2.68538226
155protein K11-linked deubiquitination (GO:0035871)2.68416781
156replication fork processing (GO:0031297)2.68278497
157regulation of glucokinase activity (GO:0033131)2.68232747
158regulation of hexokinase activity (GO:1903299)2.68232747
159respiratory chain complex IV assembly (GO:0008535)2.67504707
160inner ear receptor stereocilium organization (GO:0060122)2.65203401
161regulation of action potential (GO:0098900)2.62798487
162phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62318636
163rhodopsin mediated signaling pathway (GO:0016056)2.60960472
164DNA methylation involved in gamete generation (GO:0043046)2.60290819
165regulation of microtubule-based movement (GO:0060632)2.58871291
166positive regulation of fatty acid transport (GO:2000193)2.58394350
167ubiquinone metabolic process (GO:0006743)2.58372344
168detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58041670
169cellular biogenic amine catabolic process (GO:0042402)2.57288553
170amine catabolic process (GO:0009310)2.57288553
171positive regulation of mitochondrial fission (GO:0090141)2.56652816
172kidney morphogenesis (GO:0060993)2.53441574
173nephron tubule morphogenesis (GO:0072078)2.52828014
174nephron epithelium morphogenesis (GO:0072088)2.52828014
175pyrimidine nucleobase catabolic process (GO:0006208)2.52571220
176eye photoreceptor cell development (GO:0042462)2.52409932
177regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51728639
178protein-cofactor linkage (GO:0018065)2.51136633
179benzene-containing compound metabolic process (GO:0042537)2.50998898
180C4-dicarboxylate transport (GO:0015740)2.50167695
181regulation of hippo signaling (GO:0035330)2.45161545
182negative regulation of mast cell activation (GO:0033004)2.43100748
183proline transport (GO:0015824)2.39765020
184sperm motility (GO:0030317)2.39283096
185mannosylation (GO:0097502)2.38749435
186smoothened signaling pathway (GO:0007224)2.38190772
187reciprocal DNA recombination (GO:0035825)2.37540400
188reciprocal meiotic recombination (GO:0007131)2.37540400
189startle response (GO:0001964)2.36437431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40568795
2GBX2_23144817_ChIP-Seq_PC3_Human3.17519723
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12312863
4IGF1R_20145208_ChIP-Seq_DFB_Human3.04714543
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93293441
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79069118
7REST_21632747_ChIP-Seq_MESCs_Mouse2.74952203
8DROSHA_22980978_ChIP-Seq_HELA_Human2.73601554
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60312772
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60112256
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60112256
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56412420
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36399541
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32573218
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32480760
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31732366
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.31458558
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23860949
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.22596984
20FUS_26573619_Chip-Seq_HEK293_Human2.21917247
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20409759
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.11255645
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06536372
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03692244
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.03344323
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01698681
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00053128
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98859137
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91684065
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.91566761
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90313632
32ER_23166858_ChIP-Seq_MCF-7_Human1.88564766
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84725966
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80708419
35SMAD4_21799915_ChIP-Seq_A2780_Human1.80347794
36EWS_26573619_Chip-Seq_HEK293_Human1.78113965
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77641797
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.76533092
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.76341455
40IRF1_19129219_ChIP-ChIP_H3396_Human1.75956483
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71647463
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68085265
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65622307
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.64575721
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.63042481
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58944255
47CBP_20019798_ChIP-Seq_JUKART_Human1.53995332
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53995332
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53771738
50TP53_22573176_ChIP-Seq_HFKS_Human1.52844540
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50832140
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50829548
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50164831
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48801327
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46295814
56BCAT_22108803_ChIP-Seq_LS180_Human1.45662006
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43129347
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42002963
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40447927
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39286044
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37769284
62SOX2_19829295_ChIP-Seq_ESCs_Human1.36872665
63NANOG_19829295_ChIP-Seq_ESCs_Human1.36872665
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35937933
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35609116
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34353075
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34132187
68AR_19668381_ChIP-Seq_PC3_Human1.33545067
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30347824
70TAF15_26573619_Chip-Seq_HEK293_Human1.29568959
71AR_21572438_ChIP-Seq_LNCaP_Human1.27666309
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27372297
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.26933062
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26933062
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.26167653
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.26030392
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25433256
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25383389
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25290943
80AHR_22903824_ChIP-Seq_MCF-7_Human1.25239020
81MYC_18940864_ChIP-ChIP_HL60_Human1.24176201
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23337774
83STAT3_23295773_ChIP-Seq_U87_Human1.22845189
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20898733
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20676177
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19450668
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.19050116
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18785089
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.18570721
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.16905269
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.16171824
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16169426
93RNF2_27304074_Chip-Seq_NSC_Mouse1.16078936
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.14984536
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.14878617
96AR_25329375_ChIP-Seq_VCAP_Human1.14706289
97KDM2B_26808549_Chip-Seq_K562_Human1.14639361
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14018675
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12804490
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12517278
101NCOR_22424771_ChIP-Seq_293T_Human1.12363199
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11651618
103P300_19829295_ChIP-Seq_ESCs_Human1.11580088
104TCF4_23295773_ChIP-Seq_U87_Human1.11216375
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11082278
106HOXB7_26014856_ChIP-Seq_BT474_Human1.10828428
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.07621179
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07358793
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07271437
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06105749
111VDR_22108803_ChIP-Seq_LS180_Human1.04509786
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03736541
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.03619985
114AR_20517297_ChIP-Seq_VCAP_Human1.03395959
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02974425
116AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02254444
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.02207880
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00978457
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.99275895
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99136907
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98717431
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98656274
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.98439370
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.98345260
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97117739
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97100542
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96880647
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.95361059
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94888220
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.94854473
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.94762186
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94561270
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94201139
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94181782
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.93867130
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.93695489
137P53_22387025_ChIP-Seq_ESCs_Mouse0.93543091
138ZNF274_21170338_ChIP-Seq_K562_Hela0.93066300
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92570311
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92480925
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.91427129
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90900044
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90233596
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90233596
145RUNX2_22187159_ChIP-Seq_PCA_Human0.89894924
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89350456
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89306351
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.89216611
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.89203329
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89027411
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88555704
152CTCF_27219007_Chip-Seq_Bcells_Human0.87668546
153TCF4_22108803_ChIP-Seq_LS180_Human0.87215353
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86475467
155TBL1_22424771_ChIP-Seq_293T_Human0.86035633
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85821794
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84793133
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83811259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.09302990
2MP0009046_muscle_twitch4.08491278
3MP0004859_abnormal_synaptic_plasticity3.59278381
4MP0006292_abnormal_olfactory_placode3.37519432
5MP0001968_abnormal_touch/_nociception3.23912879
6MP0004270_analgesia3.19230321
7MP0002734_abnormal_mechanical_nocicepti3.18750140
8MP0002736_abnormal_nociception_after3.17570888
9MP0003635_abnormal_synaptic_transmissio3.05997772
10MP0002272_abnormal_nervous_system2.99997609
11MP0008877_abnormal_DNA_methylation2.99228874
12MP0008569_lethality_at_weaning2.69321801
13MP0002184_abnormal_innervation2.61581185
14MP0005551_abnormal_eye_electrophysiolog2.59407024
15MP0002067_abnormal_sensory_capabilities2.53591152
16MP0003195_calcinosis2.49180957
17MP0000569_abnormal_digit_pigmentation2.46335330
18MP0009745_abnormal_behavioral_response2.45522828
19MP0002102_abnormal_ear_morphology2.42359667
20MP0002064_seizures2.39895848
21MP0003880_abnormal_central_pattern2.35039612
22MP0003787_abnormal_imprinting2.34814370
23MP0004858_abnormal_nervous_system2.29321183
24MP0002733_abnormal_thermal_nociception2.17395242
25MP0001984_abnormal_olfaction2.12323025
26MP0005423_abnormal_somatic_nervous2.12304874
27MP0002063_abnormal_learning/memory/cond2.09878333
28MP0006072_abnormal_retinal_apoptosis2.02256055
29MP0001970_abnormal_pain_threshold2.01755747
30MP0001440_abnormal_grooming_behavior1.99922498
31MP0004782_abnormal_surfactant_physiolog1.99555564
32MP0004043_abnormal_pH_regulation1.91837137
33MP0004145_abnormal_muscle_electrophysio1.91163988
34MP0001501_abnormal_sleep_pattern1.90967439
35MP0002163_abnormal_gland_morphology1.88103335
36MP0004147_increased_porphyrin_level1.86219590
37MP0001486_abnormal_startle_reflex1.85960207
38MP0002938_white_spotting1.83075168
39MP0001502_abnormal_circadian_rhythm1.79920858
40MP0002572_abnormal_emotion/affect_behav1.73797297
41MP0002837_dystrophic_cardiac_calcinosis1.71176033
42MP0000955_abnormal_spinal_cord1.69594694
43MP0006276_abnormal_autonomic_nervous1.68157055
44MP0002229_neurodegeneration1.65697654
45MP0001529_abnormal_vocalization1.65658663
46MP0005646_abnormal_pituitary_gland1.63733954
47MP0008789_abnormal_olfactory_epithelium1.62888784
48MP0000681_abnormal_thyroid_gland1.62658284
49MP0004133_heterotaxia1.62058219
50MP0004142_abnormal_muscle_tone1.61412639
51MP0003646_muscle_fatigue1.60855939
52MP0003136_yellow_coat_color1.60569363
53MP0003879_abnormal_hair_cell1.59626987
54MP0000427_abnormal_hair_cycle1.59108228
55MP0000372_irregular_coat_pigmentation1.58277492
56MP0008875_abnormal_xenobiotic_pharmacok1.57558282
57MP0008995_early_reproductive_senescence1.57099247
58MP0005379_endocrine/exocrine_gland_phen1.56706266
59MP0004885_abnormal_endolymph1.55308923
60MP0002557_abnormal_social/conspecific_i1.55054212
61MP0003122_maternal_imprinting1.54105752
62MP0005645_abnormal_hypothalamus_physiol1.47998147
63MP0002882_abnormal_neuron_morphology1.45147971
64MP0000383_abnormal_hair_follicle1.43729937
65MP0004811_abnormal_neuron_physiology1.38860624
66MP0004742_abnormal_vestibular_system1.36073782
67MP0001188_hyperpigmentation1.35330019
68MP0005253_abnormal_eye_physiology1.35268312
69MP0003329_amyloid_beta_deposits1.30143877
70MP0002066_abnormal_motor_capabilities/c1.27896199
71MP0002752_abnormal_somatic_nervous1.27111426
72MP0000566_synostosis1.25701204
73MP0005084_abnormal_gallbladder_morpholo1.25543946
74MP0004084_abnormal_cardiac_muscle1.24764520
75MP0000631_abnormal_neuroendocrine_gland1.24680601
76MP0003632_abnormal_nervous_system1.24010891
77MP0003283_abnormal_digestive_organ1.22153851
78MP0005386_behavior/neurological_phenoty1.21904463
79MP0004924_abnormal_behavior1.21904463
80MP0005174_abnormal_tail_pigmentation1.19537511
81MP0002909_abnormal_adrenal_gland1.19333136
82MP0005083_abnormal_biliary_tract1.19222296
83MP0001177_atelectasis1.15832989
84MP0005410_abnormal_fertilization1.15563694
85MP0000778_abnormal_nervous_system1.14927826
86MP0004233_abnormal_muscle_weight1.13959735
87MP0008872_abnormal_physiological_respon1.13033479
88MP0003011_delayed_dark_adaptation1.12853156
89MP0002751_abnormal_autonomic_nervous1.12461791
90MP0001348_abnormal_lacrimal_gland1.08595016
91MP0002653_abnormal_ependyma_morphology1.08469276
92MP0004036_abnormal_muscle_relaxation1.08225465
93MP0001986_abnormal_taste_sensitivity1.08021132
94MP0001963_abnormal_hearing_physiology1.07837473
95MP0002090_abnormal_vision1.04375716
96MP0002928_abnormal_bile_duct1.04351546
97MP0003878_abnormal_ear_physiology1.03013692
98MP0005377_hearing/vestibular/ear_phenot1.03013692
99MP0001905_abnormal_dopamine_level1.02933565
100MP0003121_genomic_imprinting1.02148111
101MP0001485_abnormal_pinna_reflex1.01013832
102MP0002638_abnormal_pupillary_reflex0.99762975
103MP0003631_nervous_system_phenotype0.96722520
104MP0001324_abnormal_eye_pigmentation0.96603057
105MP0005499_abnormal_olfactory_system0.95173377
106MP0005394_taste/olfaction_phenotype0.95173377
107MP0002095_abnormal_skin_pigmentation0.91348963
108MP0000026_abnormal_inner_ear0.91158183
109MP0000534_abnormal_ureter_morphology0.89418819
110MP0002152_abnormal_brain_morphology0.89223962
111MP0003634_abnormal_glial_cell0.88639464
112MP0008775_abnormal_heart_ventricle0.88111241
113MP0003633_abnormal_nervous_system0.87293305
114MP0003698_abnormal_male_reproductive0.86886910
115MP0001293_anophthalmia0.86256038
116MP0005623_abnormal_meninges_morphology0.81708832
117MP0005389_reproductive_system_phenotype0.81426332
118MP0005195_abnormal_posterior_eye0.78802712
119MP0005167_abnormal_blood-brain_barrier0.78800633
120MP0001929_abnormal_gametogenesis0.78439008
121MP0003890_abnormal_embryonic-extraembry0.78429538
122MP0005075_abnormal_melanosome_morpholog0.78198312
123MP0010386_abnormal_urinary_bladder0.76948242
124MP0003937_abnormal_limbs/digits/tail_de0.76701430
125MP0005391_vision/eye_phenotype0.76333515
126MP0008260_abnormal_autophagy0.75584304
127MP0010678_abnormal_skin_adnexa0.74616823
128MP0000538_abnormal_urinary_bladder0.74068336
129MP0000230_abnormal_systemic_arterial0.73533449
130MP0000462_abnormal_digestive_system0.71429711
131MP0002876_abnormal_thyroid_physiology0.65435131
132MP0002160_abnormal_reproductive_system0.64769152
133MP0001943_abnormal_respiration0.61847518
134MP0004215_abnormal_myocardial_fiber0.61789953
135MP0001270_distended_abdomen0.60136989
136MP0004085_abnormal_heartbeat0.60103502
137MP0002234_abnormal_pharynx_morphology0.59584744
138MP0003137_abnormal_impulse_conducting0.59147099
139MP0002332_abnormal_exercise_endurance0.58606231
140MP0004484_altered_response_of0.58413387
141MP0001919_abnormal_reproductive_system0.58346903
142MP0001664_abnormal_digestion0.56599055
143MP0002089_abnormal_postnatal_growth/wei0.56517631
144MP0000678_abnormal_parathyroid_gland0.56022789

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.51237745
2Progressive cerebellar ataxia (HP:0002073)6.22261043
3Congenital stationary night blindness (HP:0007642)6.18975193
4Myokymia (HP:0002411)5.46947059
5Febrile seizures (HP:0002373)4.97493247
6Pancreatic cysts (HP:0001737)4.59767774
7Molar tooth sign on MRI (HP:0002419)4.37484944
8Abnormality of midbrain morphology (HP:0002418)4.37484944
9Pancreatic fibrosis (HP:0100732)4.25612854
10True hermaphroditism (HP:0010459)4.16818522
11Ulnar claw (HP:0001178)4.02122951
12Gaze-evoked nystagmus (HP:0000640)3.96130352
13Visual hallucinations (HP:0002367)3.92547978
14Epileptic encephalopathy (HP:0200134)3.88269275
15Atonic seizures (HP:0010819)3.87513936
16Focal motor seizures (HP:0011153)3.87100151
17Nephronophthisis (HP:0000090)3.71554564
18Pili torti (HP:0003777)3.60685710
19Scanning speech (HP:0002168)3.56639909
20Focal seizures (HP:0007359)3.49140054
21Goiter (HP:0000853)3.43984837
22Absence seizures (HP:0002121)3.42781919
23Medial flaring of the eyebrow (HP:0010747)3.36522280
24Ventricular fibrillation (HP:0001663)3.35673210
25Hemiparesis (HP:0001269)3.33278480
26Abnormality of the renal medulla (HP:0100957)3.28130578
27Dysdiadochokinesis (HP:0002075)3.16147069
28Impaired smooth pursuit (HP:0007772)3.09971029
29Attenuation of retinal blood vessels (HP:0007843)3.08264428
30Cystic liver disease (HP:0006706)3.06506179
31Abnormality of the renal cortex (HP:0011035)3.05800128
32Abnormality of ocular smooth pursuit (HP:0000617)3.04085325
33Type II lissencephaly (HP:0007260)3.03667503
34Abnormality of the lower motor neuron (HP:0002366)2.98354095
35Abolished electroretinogram (ERG) (HP:0000550)2.94069479
36Gait imbalance (HP:0002141)2.90700850
37Truncal ataxia (HP:0002078)2.85733862
38Abnormal rod and cone electroretinograms (HP:0008323)2.84807432
39Central scotoma (HP:0000603)2.81999895
40Hemiplegia (HP:0002301)2.81776110
41Chronic hepatic failure (HP:0100626)2.79648171
42Congenital primary aphakia (HP:0007707)2.78723466
43Supranuclear gaze palsy (HP:0000605)2.75775957
44Abnormality of binocular vision (HP:0011514)2.73517192
45Diplopia (HP:0000651)2.73517192
46Dysmetric saccades (HP:0000641)2.72728286
47Dialeptic seizures (HP:0011146)2.72634282
48Tubular atrophy (HP:0000092)2.68778403
49Abnormal drinking behavior (HP:0030082)2.67957187
50Polydipsia (HP:0001959)2.67957187
51Hyperventilation (HP:0002883)2.64772380
52Nephrogenic diabetes insipidus (HP:0009806)2.57612964
53Abnormality of macular pigmentation (HP:0008002)2.56691224
54Pendular nystagmus (HP:0012043)2.56019732
55Split foot (HP:0001839)2.54784071
56Generalized tonic-clonic seizures (HP:0002069)2.49528844
57Severe visual impairment (HP:0001141)2.47455251
58Increased corneal curvature (HP:0100692)2.46676068
59Keratoconus (HP:0000563)2.46676068
60Postural tremor (HP:0002174)2.45537473
61Sclerocornea (HP:0000647)2.44405291
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.41483040
63Thyroid carcinoma (HP:0002890)2.41281053
64Genetic anticipation (HP:0003743)2.41074154
65Inability to walk (HP:0002540)2.39966783
66Limb ataxia (HP:0002070)2.37431407
67Anencephaly (HP:0002323)2.36203208
68Horizontal nystagmus (HP:0000666)2.35532641
69Intention tremor (HP:0002080)2.35479293
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34674181
71Abnormality of alanine metabolism (HP:0010916)2.34674181
72Hyperalaninemia (HP:0003348)2.34674181
73Congenital hepatic fibrosis (HP:0002612)2.32579934
74Hypothermia (HP:0002045)2.32462219
75Postaxial foot polydactyly (HP:0001830)2.29326507
76Dysmetria (HP:0001310)2.29201823
77Polyuria (HP:0000103)2.24451372
78Tetany (HP:0001281)2.22163452
79Cerebellar dysplasia (HP:0007033)2.21948776
80Genital tract atresia (HP:0001827)2.21619799
81Fetal akinesia sequence (HP:0001989)2.20490216
82Colon cancer (HP:0003003)2.18422328
83Status epilepticus (HP:0002133)2.17582432
84Depression (HP:0000716)2.16185868
85Progressive inability to walk (HP:0002505)2.16095708
86Vaginal atresia (HP:0000148)2.16067743
87Abnormal biliary tract physiology (HP:0012439)2.14241081
88Bile duct proliferation (HP:0001408)2.14241081
89Pheochromocytoma (HP:0002666)2.13957028
90Optic nerve hypoplasia (HP:0000609)2.12640761
91Lissencephaly (HP:0001339)2.10959396
92Lower limb asymmetry (HP:0100559)2.09813191
93Furrowed tongue (HP:0000221)2.08332355
94Abnormality of the fovea (HP:0000493)2.06718115
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.03904426
96Absent/shortened dynein arms (HP:0200106)2.03904426
97Decreased central vision (HP:0007663)2.03381584
98Bony spicule pigmentary retinopathy (HP:0007737)2.02792859
99Anxiety (HP:0000739)2.01958573
100Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01199570
101Steppage gait (HP:0003376)2.00829908
102Renal cortical cysts (HP:0000803)2.00529411
103Male pseudohermaphroditism (HP:0000037)1.98890045
104Large for gestational age (HP:0001520)1.98627370
105Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98232889
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97835533
107Ankle clonus (HP:0011448)1.97395940
108Thyroid-stimulating hormone excess (HP:0002925)1.97021446
109Hypoplasia of the fovea (HP:0007750)1.96499071
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.96499071
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.95808788
112Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.95748232
113Retinal dysplasia (HP:0007973)1.94941641
114Acute necrotizing encephalopathy (HP:0006965)1.94746537
115Poor coordination (HP:0002370)1.94538176
116Septo-optic dysplasia (HP:0100842)1.93909502
117Postural instability (HP:0002172)1.93803162
118Broad-based gait (HP:0002136)1.93274906
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.92066636
120Stenosis of the external auditory canal (HP:0000402)1.91664881
121Oligodactyly (hands) (HP:0001180)1.91349443
122Abnormality of saccadic eye movements (HP:0000570)1.91258925
123Annular pancreas (HP:0001734)1.91112756
124Mutism (HP:0002300)1.90708309
125Concave nail (HP:0001598)1.90170068
126Scotoma (HP:0000575)1.89209416
127Postaxial hand polydactyly (HP:0001162)1.88947927
128Hyperglycinuria (HP:0003108)1.88523503
129Congenital sensorineural hearing impairment (HP:0008527)1.88061913
130Abnormal respiratory epithelium morphology (HP:0012253)1.87095227
131Abnormal respiratory motile cilium morphology (HP:0005938)1.87095227
132Asplenia (HP:0001746)1.86478169
133Choroideremia (HP:0001139)1.85522839
134Acute encephalopathy (HP:0006846)1.83643414
135Hyperglycinemia (HP:0002154)1.83550361
136Progressive macrocephaly (HP:0004481)1.83405655
137Increased CSF lactate (HP:0002490)1.83048236
138Spinal canal stenosis (HP:0003416)1.82990725
139Mitochondrial inheritance (HP:0001427)1.82678677
140Disproportionate short-trunk short stature (HP:0003521)1.80730428
141Decreased circulating renin level (HP:0003351)1.80703411
142Ketosis (HP:0001946)1.80252880
143Tetraplegia (HP:0002445)1.79118031
144Foot dorsiflexor weakness (HP:0009027)1.78551447
145Segmental peripheral demyelination/remyelination (HP:0003481)1.78481724
146Abnormal urine output (HP:0012590)1.78401034
147Neuroendocrine neoplasm (HP:0100634)1.77503149
148Hyperphosphatemia (HP:0002905)1.77318785
149Methylmalonic acidemia (HP:0002912)1.76964221
150Preaxial hand polydactyly (HP:0001177)1.76371589
151Occipital encephalocele (HP:0002085)1.76316901
152Gait ataxia (HP:0002066)1.75260734
153Retinitis pigmentosa (HP:0000510)1.74677062
154Diastasis recti (HP:0001540)1.74431896
155Incomplete penetrance (HP:0003829)1.74168498
156Ketoacidosis (HP:0001993)1.73566140
157Myotonia (HP:0002486)1.72952475
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.72900389
159Optic disc pallor (HP:0000543)1.72791341
160Prolonged QT interval (HP:0001657)1.71695773
161Spastic paraplegia (HP:0001258)1.71313340
162Morphological abnormality of the pyramidal tract (HP:0002062)1.71092209
163Abnormal eating behavior (HP:0100738)1.70082402
164Urinary urgency (HP:0000012)1.70053928
165Paraplegia (HP:0010550)1.68989292
166Neoplasm of the thyroid gland (HP:0100031)1.67597082
167Clonus (HP:0002169)1.67540915
168Bundle branch block (HP:0011710)1.65679208
169Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.64000445
170Hand muscle atrophy (HP:0009130)1.63250731
171Broad metatarsal (HP:0001783)1.61562725
172Renal salt wasting (HP:0000127)1.61040945
173EEG with generalized epileptiform discharges (HP:0011198)1.58680702
174Abnormality of the foot musculature (HP:0001436)1.58355943
175Decreased motor nerve conduction velocity (HP:0003431)1.55726356
176Neuroblastic tumors (HP:0004376)1.55630492
177Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.55630492
178Neuroblastoma (HP:0003006)1.55630492
179Primitive neuroectodermal tumor (HP:0030065)1.55630492
180Abnormal hair laboratory examination (HP:0003328)1.55565392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.87744726
2MAP3K93.53269580
3NTRK33.35677473
4LMTK23.34730435
5MINK13.33844579
6MAP4K23.27268799
7ADRBK23.15487522
8MAP3K43.04413990
9RIPK12.99167021
10BMPR1B2.75713605
11CAMKK22.73924474
12WNK32.64826082
13AKT32.54969203
14WNK12.53050330
15TAOK32.44021039
16STK382.40931542
17MAP2K72.24935195
18PRPF4B2.13545798
19NEK12.10682995
20PAK62.09973344
21NUAK12.08182584
22ZAK2.04882287
23DAPK22.00368716
24ACVR1B1.91162790
25PHKG11.83822423
26PHKG21.83822423
27SGK21.79079854
28CAMKK11.76683621
29TLK11.74359873
30PINK11.63691807
31SGK2231.61793412
32SGK4941.61793412
33TRIM281.55305627
34MAP2K41.53716810
35STK38L1.53615560
36NTRK11.42583896
37PRKCG1.37885016
38SGK31.36922966
39LATS21.35517129
40MKNK21.29797441
41MARK11.21180739
42PRKG21.20046016
43PNCK1.19453130
44MAPK131.17692023
45BCKDK1.15128013
46GRK51.12562234
47ADRBK11.12458452
48GRK11.11187677
49TXK1.10781279
50MAP3K121.10239852
51BRSK21.09245175
52PTK2B1.08508411
53NEK61.06368012
54PDK41.03851880
55PDK31.03851880
56NME11.03607323
57EPHA41.03502056
58TAOK21.00011469
59RET0.99504120
60PLK20.96618416
61TNK20.93035424
62CASK0.92886000
63DYRK20.91324068
64DYRK1A0.90839740
65KSR20.90823432
66EPHA20.89947454
67STK390.87643832
68FER0.87478390
69OXSR10.86598767
70CAMK2G0.86559744
71CSNK1G20.85085526
72NTRK20.84245973
73CSNK1G10.82583126
74WEE10.81997858
75MAP3K20.79828405
76WNK40.79395470
77TGFBR10.78879165
78MKNK10.78264453
79MAPK150.77330414
80CSNK1G30.77083048
81PLK40.75688443
82TIE10.75178704
83CDC42BPA0.75078121
84CDK50.75075236
85SCYL20.74363778
86CAMK10.73671838
87ROCK20.71631645
88MUSK0.71296044
89FGFR20.70497599
90CSNK1A1L0.68903913
91LATS10.67624836
92CAMK2D0.67515403
93IRAK10.67051577
94TNIK0.66499763
95VRK10.65436148
96CDK140.63397116
97MAPKAPK30.63017366
98LIMK10.61930820
99PRKCH0.61754511
100CDK180.61521502
101BRAF0.61424257
102STK30.59588482
103PKN10.59072459
104CDK150.59060756
105MATK0.57929870
106PRKACA0.56757125
107PRKACB0.55357463
108ALK0.55178338
109PRKG10.54567855
110TEC0.54398077
111MAP2K60.53945904
112PTK20.53491400
113BRSK10.53433547
114BCR0.53386990
115PRKD30.53163614
116STK110.52772578
117PLK30.52104072
118PIK3CA0.51980814
119CAMK2A0.51275723
120CSNK1A10.50605243
121ERBB20.49416710
122CSNK1E0.48999395
123SGK10.48679562
124CAMK40.48139735
125FLT30.47614156
126CDK190.46293770
127ERBB30.46091034
128DAPK10.45271613
129CDK11A0.45043304
130STK160.44774015
131PDK20.44753310
132RPS6KB20.44675078
133CAMK2B0.43763451
134TSSK60.43722260
135RPS6KA50.43221502
136RPS6KA30.42666835
137PAK30.42179830
138BMPR20.41995780
139INSRR0.41764767
140PRKCQ0.41484412
141MST40.41157178
142RIPK40.40832224
143PRKCI0.40024409
144IKBKB0.39728235
145EPHA30.39677867
146MAPK100.39658721
147PRKCZ0.38453435
148TAOK10.38338919
149PRKCE0.37254401
150PRKCA0.37136211
151MAP2K10.36825886
152GSK3B0.36338439
153CSNK1D0.34901389
154PRKAA10.33514112
155DYRK30.31769882
156MAPKAPK50.30924217
157PLK10.29978212
158EPHB20.28416327
159CHUK0.27913847
160NLK0.26413642

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25252414
2Synaptic vesicle cycle_Homo sapiens_hsa047213.85835278
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.86375319
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.78902013
5Nitrogen metabolism_Homo sapiens_hsa009102.77786210
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75504090
7Linoleic acid metabolism_Homo sapiens_hsa005912.69968337
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69443061
9Butanoate metabolism_Homo sapiens_hsa006502.67346577
10GABAergic synapse_Homo sapiens_hsa047272.64789156
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64739009
12Taste transduction_Homo sapiens_hsa047422.60069113
13Circadian entrainment_Homo sapiens_hsa047132.47916413
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.47124878
15Glutamatergic synapse_Homo sapiens_hsa047242.36986016
16Salivary secretion_Homo sapiens_hsa049702.26468338
17Morphine addiction_Homo sapiens_hsa050322.23836138
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18572645
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.17743089
20Olfactory transduction_Homo sapiens_hsa047402.09210595
21Long-term potentiation_Homo sapiens_hsa047202.08708252
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07799929
23Gastric acid secretion_Homo sapiens_hsa049712.03758461
24Thyroid hormone synthesis_Homo sapiens_hsa049182.02577329
25Long-term depression_Homo sapiens_hsa047301.94177362
26Protein export_Homo sapiens_hsa030601.90785239
27Insulin secretion_Homo sapiens_hsa049111.84802115
28Tryptophan metabolism_Homo sapiens_hsa003801.83295147
29Ether lipid metabolism_Homo sapiens_hsa005651.82272208
30Oxidative phosphorylation_Homo sapiens_hsa001901.71001429
31Phototransduction_Homo sapiens_hsa047441.67858752
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62438003
33Dopaminergic synapse_Homo sapiens_hsa047281.61468511
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.60152216
35Mineral absorption_Homo sapiens_hsa049781.59893284
36Cholinergic synapse_Homo sapiens_hsa047251.58385157
37Propanoate metabolism_Homo sapiens_hsa006401.57015980
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56633124
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55022400
40Amphetamine addiction_Homo sapiens_hsa050311.54064392
41Homologous recombination_Homo sapiens_hsa034401.51751729
42Selenocompound metabolism_Homo sapiens_hsa004501.48756330
43Fanconi anemia pathway_Homo sapiens_hsa034601.48240168
44Collecting duct acid secretion_Homo sapiens_hsa049661.47261250
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46083798
46Cardiac muscle contraction_Homo sapiens_hsa042601.43469424
47Renin secretion_Homo sapiens_hsa049241.43070779
48RNA polymerase_Homo sapiens_hsa030201.41229925
49Basal transcription factors_Homo sapiens_hsa030221.39482495
50Oxytocin signaling pathway_Homo sapiens_hsa049211.37441472
51Serotonergic synapse_Homo sapiens_hsa047261.36987929
52Autoimmune thyroid disease_Homo sapiens_hsa053201.35978641
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.32016925
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30919828
55Calcium signaling pathway_Homo sapiens_hsa040201.29353221
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29001926
57Parkinsons disease_Homo sapiens_hsa050121.26676581
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26645737
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24314325
60Peroxisome_Homo sapiens_hsa041461.19636796
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.18084957
62ABC transporters_Homo sapiens_hsa020101.17213859
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16741868
64Inositol phosphate metabolism_Homo sapiens_hsa005621.15847112
65Type II diabetes mellitus_Homo sapiens_hsa049301.15157668
66Arachidonic acid metabolism_Homo sapiens_hsa005901.14450723
67Chemical carcinogenesis_Homo sapiens_hsa052041.14353229
68Caffeine metabolism_Homo sapiens_hsa002321.14254866
69Gap junction_Homo sapiens_hsa045401.11756635
70Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09979586
71Circadian rhythm_Homo sapiens_hsa047101.09464243
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08456024
73cAMP signaling pathway_Homo sapiens_hsa040241.06682627
74GnRH signaling pathway_Homo sapiens_hsa049121.05763890
75RNA degradation_Homo sapiens_hsa030181.04898720
76Pancreatic secretion_Homo sapiens_hsa049721.04304074
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99175819
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98897654
79Oocyte meiosis_Homo sapiens_hsa041140.98677135
80Estrogen signaling pathway_Homo sapiens_hsa049150.94901355
81Retinol metabolism_Homo sapiens_hsa008300.93900573
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93461249
83beta-Alanine metabolism_Homo sapiens_hsa004100.92839275
84Huntingtons disease_Homo sapiens_hsa050160.89280515
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.88319453
86One carbon pool by folate_Homo sapiens_hsa006700.87234459
87Fructose and mannose metabolism_Homo sapiens_hsa000510.86939839
88Regulation of autophagy_Homo sapiens_hsa041400.86851388
89Histidine metabolism_Homo sapiens_hsa003400.86646705
90Fat digestion and absorption_Homo sapiens_hsa049750.85850661
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85177688
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82835980
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82717446
94Glycerolipid metabolism_Homo sapiens_hsa005610.80964035
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.80653524
96Bile secretion_Homo sapiens_hsa049760.78899255
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78039259
98Alzheimers disease_Homo sapiens_hsa050100.75520376
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74974664
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73028410
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68686080
102Dilated cardiomyopathy_Homo sapiens_hsa054140.66023530
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.65821071
104Fatty acid degradation_Homo sapiens_hsa000710.65357338
105Metabolic pathways_Homo sapiens_hsa011000.65003764
106Melanoma_Homo sapiens_hsa052180.63806830
107Vibrio cholerae infection_Homo sapiens_hsa051100.61801060
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61308708
109Fatty acid elongation_Homo sapiens_hsa000620.61283881
110ErbB signaling pathway_Homo sapiens_hsa040120.58966567
111Cocaine addiction_Homo sapiens_hsa050300.58253452
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.58206505
113Purine metabolism_Homo sapiens_hsa002300.57812262
114Melanogenesis_Homo sapiens_hsa049160.57063033
115Endometrial cancer_Homo sapiens_hsa052130.56942225
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56774634
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.56305794
118Glioma_Homo sapiens_hsa052140.52077481
119Sulfur relay system_Homo sapiens_hsa041220.50978899
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50758870
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50638064
122Glucagon signaling pathway_Homo sapiens_hsa049220.48413793
123Dorso-ventral axis formation_Homo sapiens_hsa043200.48158126
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48016197
125mTOR signaling pathway_Homo sapiens_hsa041500.47308129
126Choline metabolism in cancer_Homo sapiens_hsa052310.47024470
127Fatty acid metabolism_Homo sapiens_hsa012120.46881909
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46643623
129MAPK signaling pathway_Homo sapiens_hsa040100.45761314
130Steroid biosynthesis_Homo sapiens_hsa001000.44937922
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44289057
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43887684
133Non-homologous end-joining_Homo sapiens_hsa034500.42408045
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42225897
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40546181
136Fatty acid biosynthesis_Homo sapiens_hsa000610.40380428
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38096073
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.38053077
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37967281
140Rap1 signaling pathway_Homo sapiens_hsa040150.37105048
141Sulfur metabolism_Homo sapiens_hsa009200.36179804
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36080592
143Insulin signaling pathway_Homo sapiens_hsa049100.35868231
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33630610
145Hedgehog signaling pathway_Homo sapiens_hsa043400.32508029
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.31862833
147Axon guidance_Homo sapiens_hsa043600.31267150
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.31167713
149Tight junction_Homo sapiens_hsa045300.30858069
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30277224
151Ovarian steroidogenesis_Homo sapiens_hsa049130.30104655
152VEGF signaling pathway_Homo sapiens_hsa043700.29745169
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29429358
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28960627
155Thyroid cancer_Homo sapiens_hsa052160.28728072
156Hippo signaling pathway_Homo sapiens_hsa043900.28268464
157Ras signaling pathway_Homo sapiens_hsa040140.27463786
158Endocytosis_Homo sapiens_hsa041440.25196384
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23800088
160SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23710257
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.23415371
162HIF-1 signaling pathway_Homo sapiens_hsa040660.22481345

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