PLEKHF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.53115970
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.53115970
3cellular response to interleukin-15 (GO:0071350)5.55857031
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36416460
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.15351922
6response to interleukin-15 (GO:0070672)5.06854985
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92246514
8positive regulation of gamma-delta T cell activation (GO:0046645)4.73900485
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69535322
10antigen processing and presentation of endogenous antigen (GO:0019883)4.60487356
11T cell migration (GO:0072678)4.57764360
12positive thymic T cell selection (GO:0045059)4.51063924
13thymic T cell selection (GO:0045061)4.42260583
14negative T cell selection (GO:0043383)4.36798964
15negative thymic T cell selection (GO:0045060)4.36599610
16regulation of B cell receptor signaling pathway (GO:0050855)4.34256395
17L-serine metabolic process (GO:0006563)4.34026067
18positive regulation of T cell mediated cytotoxicity (GO:0001916)4.31122766
19regulation of T cell mediated cytotoxicity (GO:0001914)4.27941265
20regulation of gamma-delta T cell differentiation (GO:0045586)4.27707669
21negative regulation of fatty acid biosynthetic process (GO:0045717)4.19763562
22chronic inflammatory response (GO:0002544)3.94803556
23serine family amino acid biosynthetic process (GO:0009070)3.93883130
24regulation of gamma-delta T cell activation (GO:0046643)3.93410128
25tolerance induction (GO:0002507)3.88585636
26cytidine metabolic process (GO:0046087)3.88578846
27cytidine catabolic process (GO:0006216)3.88578846
28cytidine deamination (GO:0009972)3.88578846
29folic acid metabolic process (GO:0046655)3.85482365
30leukocyte aggregation (GO:0070486)3.80440920
31regulation of memory T cell differentiation (GO:0043380)3.78219549
32regulation of activation of Janus kinase activity (GO:0010533)3.77942924
33folic acid transport (GO:0015884)3.68397717
34regulation of leukocyte mediated cytotoxicity (GO:0001910)3.65151169
35positive T cell selection (GO:0043368)3.61778548
36T cell selection (GO:0045058)3.58899939
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.55722160
38regulation of T cell tolerance induction (GO:0002664)3.54336455
39regulation of natural killer cell mediated immunity (GO:0002715)3.53535644
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53535644
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.52292316
42negative regulation of leukocyte mediated immunity (GO:0002704)3.51739039
43regulation of alpha-beta T cell proliferation (GO:0046640)3.48208778
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.47538011
45sulfur amino acid catabolic process (GO:0000098)3.46444471
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.44581758
47negative regulation of innate immune response (GO:0045824)3.40833735
48lymphocyte migration (GO:0072676)3.40667672
49glycine metabolic process (GO:0006544)3.35174132
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.32519850
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.30035936
52proteasome assembly (GO:0043248)3.29591768
53regulation of cell killing (GO:0031341)3.27477632
54lymphocyte chemotaxis (GO:0048247)3.24500975
55heme transport (GO:0015886)3.24236718
56positive regulation of interleukin-17 production (GO:0032740)3.23130297
57type I interferon signaling pathway (GO:0060337)3.22778324
58cellular response to type I interferon (GO:0071357)3.22778324
59response to type I interferon (GO:0034340)3.19787716
60skin morphogenesis (GO:0043589)3.19401232
61positive regulation of cell killing (GO:0031343)3.19093778
62regulation of regulatory T cell differentiation (GO:0045589)3.18946174
63L-phenylalanine metabolic process (GO:0006558)3.18449019
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.18449019
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17826503
66creatine metabolic process (GO:0006600)3.17401303
67dendritic cell chemotaxis (GO:0002407)3.15535505
68positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14412549
69positive regulation of T cell mediated immunity (GO:0002711)3.13423797
70L-methionine salvage (GO:0071267)3.12532405
71L-methionine biosynthetic process (GO:0071265)3.12532405
72amino acid salvage (GO:0043102)3.12532405
73serine family amino acid metabolic process (GO:0009069)3.08662887
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06143544
75NIK/NF-kappaB signaling (GO:0038061)3.05099470
76positive regulation of defense response to virus by host (GO:0002230)3.03928833
77negative regulation of T cell mediated immunity (GO:0002710)3.03083620
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00275275
79T cell receptor signaling pathway (GO:0050852)2.97269323
80regulation of T cell mediated immunity (GO:0002709)2.96909925
81peptidyl-proline hydroxylation (GO:0019511)2.96424674
82response to muramyl dipeptide (GO:0032495)2.94930027
83ribosome assembly (GO:0042255)2.94315627
84eosinophil chemotaxis (GO:0048245)2.94306580
85positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92312649
86positive regulation of natural killer cell mediated immunity (GO:0002717)2.90835278
87cellular defense response (GO:0006968)2.89634989
88positive regulation of tolerance induction (GO:0002645)2.89436895
89serine family amino acid catabolic process (GO:0009071)2.89373923
90negative regulation of fatty acid metabolic process (GO:0045922)2.88359462
91regulation of tolerance induction (GO:0002643)2.87729147
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.87650159
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87267333
94regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87024904
95negative regulation of fibrinolysis (GO:0051918)2.86275096
96positive regulation of T-helper 1 type immune response (GO:0002827)2.85884168
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85777190
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85414903
99glyoxylate metabolic process (GO:0046487)2.84641917
100epoxygenase P450 pathway (GO:0019373)2.84437306
1014-hydroxyproline metabolic process (GO:0019471)2.83123380
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.82741664
103L-phenylalanine catabolic process (GO:0006559)2.82741664
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81355859
105protein heterotrimerization (GO:0070208)2.80394264
106regulation of T-helper 1 type immune response (GO:0002825)2.80185779
107mast cell activation (GO:0045576)2.78389678
108regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.78337092
109regulation of T cell receptor signaling pathway (GO:0050856)2.77188508
110muscle filament sliding (GO:0030049)2.76229070
111actin-myosin filament sliding (GO:0033275)2.76229070
112antigen processing and presentation via MHC class Ib (GO:0002475)2.75246720
113antigen receptor-mediated signaling pathway (GO:0050851)2.74988450
114positive regulation of interleukin-4 production (GO:0032753)2.74578822
115negative regulation of T cell apoptotic process (GO:0070233)2.73167136
116regulation of alpha-beta T cell activation (GO:0046634)2.72644398
117negative regulation of type 2 immune response (GO:0002829)2.70274424
118lymph node development (GO:0048535)2.68707904
119protein carboxylation (GO:0018214)2.68620056
120peptidyl-glutamic acid carboxylation (GO:0017187)2.68620056
121tumor necrosis factor-mediated signaling pathway (GO:0033209)2.68543741
122collagen fibril organization (GO:0030199)2.66883704
123low-density lipoprotein particle clearance (GO:0034383)2.66474005
124regulation of B cell differentiation (GO:0045577)2.65756834
125regulation of T cell chemotaxis (GO:0010819)2.65689881
126positive regulation of T cell chemotaxis (GO:0010820)2.65689881
127leukocyte degranulation (GO:0043299)2.65371036
128sulfur amino acid biosynthetic process (GO:0000097)2.65117050
129formation of translation preinitiation complex (GO:0001731)2.64830810
130regulation of integrin-mediated signaling pathway (GO:2001044)2.64828801
131regulation of defense response to virus by host (GO:0050691)2.64821536
132AMP metabolic process (GO:0046033)2.64690985
133T cell costimulation (GO:0031295)2.64131360
134immunoglobulin mediated immune response (GO:0016064)2.63142414
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62213446
136CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.60089050
137T-helper cell differentiation (GO:0042093)2.60089050
138oxygen transport (GO:0015671)2.60013308
139cranial suture morphogenesis (GO:0060363)2.59941304
140amino-acid betaine metabolic process (GO:0006577)2.59758604
141endodermal cell differentiation (GO:0035987)2.59725067
142lymphocyte costimulation (GO:0031294)2.59700930
143regulation of lymphocyte chemotaxis (GO:1901623)2.59398948
144regulation of defense response to virus by virus (GO:0050690)2.59301098
145negative regulation of T-helper cell differentiation (GO:0045623)2.59120135
146alpha-linolenic acid metabolic process (GO:0036109)2.58588314
147regulation of SMAD protein import into nucleus (GO:0060390)2.58189940
148branched-chain amino acid catabolic process (GO:0009083)2.58028828
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.57433606
150epithelial cell-cell adhesion (GO:0090136)2.56721262
151modified amino acid transport (GO:0072337)2.51510407
152cysteine metabolic process (GO:0006534)2.51106370
153purine nucleobase biosynthetic process (GO:0009113)2.51074177
154eosinophil migration (GO:0072677)2.50083225
155regulation of fatty acid biosynthetic process (GO:0042304)2.46783903
156negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.46696529
157aspartate family amino acid biosynthetic process (GO:0009067)2.46118849
158aspartate family amino acid metabolic process (GO:0009066)2.46068300
159homocysteine metabolic process (GO:0050667)2.43543501
160alpha-amino acid biosynthetic process (GO:1901607)2.43177032
161methionine biosynthetic process (GO:0009086)2.40973581
162regulation of protein activation cascade (GO:2000257)2.40125170
163regulation of complement activation (GO:0030449)2.39818154
164folic acid-containing compound metabolic process (GO:0006760)2.39536361
165positive regulation of triglyceride lipase activity (GO:0061365)2.39216789
166positive regulation of lipoprotein lipase activity (GO:0051006)2.39216789
167branching involved in mammary gland duct morphogenesis (GO:0060444)2.39144138
168extracellular matrix assembly (GO:0085029)2.38630107
169regulation of plasminogen activation (GO:0010755)2.38265528
170acetyl-CoA metabolic process (GO:0006084)2.37126595
171protein hydroxylation (GO:0018126)2.35959706
172bone trabecula formation (GO:0060346)2.33963590
173sulfur amino acid metabolic process (GO:0000096)2.32626666
174regulation of metalloenzyme activity (GO:0048552)2.32388244
175endothelial cell morphogenesis (GO:0001886)2.31092160
176cofactor transport (GO:0051181)2.30315449
177positive regulation of fatty acid beta-oxidation (GO:0032000)2.30294195
178branched-chain amino acid metabolic process (GO:0009081)2.29661725
179fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29589150
180biotin metabolic process (GO:0006768)2.29046793
181lung-associated mesenchyme development (GO:0060484)2.28665775
182interleukin-6-mediated signaling pathway (GO:0070102)2.28067379
183interferon-gamma secretion (GO:0072643)2.27979392
184chondrocyte proliferation (GO:0035988)2.27221773
185regulation of triglyceride catabolic process (GO:0010896)2.27156876
186COPII vesicle coating (GO:0048208)2.24940536
187nucleotide-sugar biosynthetic process (GO:0009226)2.24904496
188lysine metabolic process (GO:0006553)2.22847479
189lysine catabolic process (GO:0006554)2.22847479
190nucleobase biosynthetic process (GO:0046112)2.20054203
191gap junction assembly (GO:0016264)2.19884194
192regulation of cholesterol homeostasis (GO:2000188)2.19759179
193methionine metabolic process (GO:0006555)2.19649216
194regulation of fibrinolysis (GO:0051917)2.18826697
195fatty acid beta-oxidation (GO:0006635)2.18795793
196fibrinolysis (GO:0042730)2.18721945
197galactose catabolic process (GO:0019388)2.18219366
198positive regulation of extracellular matrix organization (GO:1903055)2.17399590
199ADP metabolic process (GO:0046031)2.17376431
200plasma lipoprotein particle clearance (GO:0034381)2.14559086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.10448496
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.82472648
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.81832363
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.81728036
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74402389
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.28227133
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23549274
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.20801444
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12004231
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05927438
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.81556143
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69034635
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59758993
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57345665
15* RUNX_20019798_ChIP-Seq_JUKART_Human2.54898848
16* MAF_26560356_Chip-Seq_TH1_Human2.49081542
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48558768
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.46465831
19VDR_21846776_ChIP-Seq_THP-1_Human2.45474772
20MYC_22102868_ChIP-Seq_BL_Human2.45262623
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43001531
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28690295
23UTX_26944678_Chip-Seq_JUKART_Human2.27524047
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26066134
25MYB_26560356_Chip-Seq_TH2_Human2.23680127
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20548287
27CLOCK_20551151_ChIP-Seq_293T_Human2.16535298
28STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16248409
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11213514
30* MAF_26560356_Chip-Seq_TH2_Human2.11071494
31IRF8_21731497_ChIP-ChIP_J774_Mouse2.09463007
32ZNF263_19887448_ChIP-Seq_K562_Human2.07756740
33* LXR_22158963_ChIP-Seq_LIVER_Mouse2.05592905
34AR_21909140_ChIP-Seq_LNCAP_Human2.04647793
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02730421
36* LXR_22292898_ChIP-Seq_THP-1_Human2.01552187
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01006601
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98680353
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.98034737
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90535973
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89935758
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89616967
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88149640
44TCF7_22412390_ChIP-Seq_EML_Mouse1.87356605
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84769314
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83847247
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83163910
48MYB_26560356_Chip-Seq_TH1_Human1.82765917
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82598659
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82598659
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82598659
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81860160
53* KDM2B_26808549_Chip-Seq_DND41_Human1.80333866
54VDR_24763502_ChIP-Seq_THP-1_Human1.80027159
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78472340
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78202332
57* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76523584
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76424630
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76420989
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72701988
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71706614
62SCL_19346495_ChIP-Seq_HPC-7_Human1.70261486
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69201644
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67298019
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64686829
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64045620
67* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62771658
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60933423
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58649573
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58130315
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56721118
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56098513
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.55861643
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53533497
75ATF3_27146783_Chip-Seq_COLON_Human1.53046009
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.52815205
77* ESR2_21235772_ChIP-Seq_MCF-7_Human1.51895331
78* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51330729
79* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50607495
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48001626
81* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47379974
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46934653
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46708704
84BCL6_27268052_Chip-Seq_Bcells_Human1.46420671
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46154214
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44446943
87* SPI1_23547873_ChIP-Seq_NB4_Human1.44237272
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44022877
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43525784
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42961536
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41994705
92P68_20966046_ChIP-Seq_HELA_Human1.41872142
93* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.41779904
94GATA3_27048872_Chip-Seq_THYMUS_Human1.41759812
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41416267
96* ELK3_25401928_ChIP-Seq_HUVEC_Human1.40949188
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40936704
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40178641
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39962255
100* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38280090
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.37104157
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36997981
103BCOR_27268052_Chip-Seq_Bcells_Human1.36247861
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36225787
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35839094
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35284897
107* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33623956
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32546486
109SPI1_23127762_ChIP-Seq_K562_Human1.32178476
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.31668090
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30774973
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30732912
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28910173
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28650368
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.28034312
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26347751
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25830134
118* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25219039
119RACK7_27058665_Chip-Seq_MCF-7_Human1.24415608
120* ESR1_21235772_ChIP-Seq_MCF-7_Human1.24308415
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23328712
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23236648
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23072773
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21934769
125ELK1_22589737_ChIP-Seq_MCF10A_Human1.21116562
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20915378
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20763957
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19713944
129SA1_27219007_Chip-Seq_Bcells_Human1.17700459
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16974991
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16387213
132DCP1A_22483619_ChIP-Seq_HELA_Human1.16258493
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16048491
134PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14991231
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14762079
136GATA1_19941827_ChIP-Seq_MEL_Mouse1.14403292
137TET1_21451524_ChIP-Seq_MESCs_Mouse1.13136182
138CTCF_26484167_Chip-Seq_Bcells_Mouse1.12677744
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12310242
140HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12039123
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11988417
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11748847
143GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10642168
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10267812
145* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09891511
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09636017
147* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09522124
148XRN2_22483619_ChIP-Seq_HELA_Human1.08557987
149CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06626103
150SPI1_20517297_ChIP-Seq_HL60_Human1.05141548
151* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02476215
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02354189
153ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02157058
154EST1_17652178_ChIP-ChIP_JURKAT_Human1.01890010
155CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01723028
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.99545767
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98994083
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98843680
159FOXM1_23109430_ChIP-Seq_U2OS_Human0.98768402
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98518516
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98101195
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98023362
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.96889681
164PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96243553
165* GATA3_26560356_Chip-Seq_TH2_Human0.96090954
166GATA1_22025678_ChIP-Seq_K562_Human0.96078404
167* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95786862
168* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95786862
169FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95690101
170NCOR1_26117541_ChIP-Seq_K562_Human0.94709504
171NOTCH1_21737748_ChIP-Seq_TLL_Human0.94239634
172SMC4_20622854_ChIP-Seq_HELA_Human0.93744672
173TP53_22127205_ChIP-Seq_IMR90_Human0.93592674
174UBF1/2_26484160_Chip-Seq_HMECs_Human0.91949890
175KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90919304
176P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90889357
177MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90603601
178EGR1_19374776_ChIP-ChIP_THP-1_Human0.89993831
179TFEB_21752829_ChIP-Seq_HELA_Human0.89274133
180SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88067976
181CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87775466
182GATA4_25053715_ChIP-Seq_YYC3_Human0.87025650
183GABP_19822575_ChIP-Seq_HepG2_Human0.86286079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.17852125
2MP0005671_abnormal_response_to4.22093761
3MP0003705_abnormal_hypodermis_morpholog3.89770672
4MP0003763_abnormal_thymus_physiology3.63666956
5MP0003436_decreased_susceptibility_to3.42956685
6MP0003724_increased_susceptibility_to3.37072585
7MP0003806_abnormal_nucleotide_metabolis3.17474804
8MP0009840_abnormal_foam_cell3.04464238
9MP0005275_abnormal_skin_tensile3.02064929
10MP0005000_abnormal_immune_tolerance2.81046468
11MP0002139_abnormal_hepatobiliary_system2.70745914
12MP0005503_abnormal_tendon_morphology2.62555768
13MP0001835_abnormal_antigen_presentation2.58720671
14MP0009785_altered_susceptibility_to2.52395316
15MP0000685_abnormal_immune_system2.47821365
16MP0001800_abnormal_humoral_immune2.46565591
17MP0009333_abnormal_splenocyte_physiolog2.41452038
18MP0005360_urolithiasis2.39919577
19MP0002723_abnormal_immune_serum2.36574388
20MP0005025_abnormal_response_to2.34865332
21MP0001790_abnormal_immune_system2.30406139
22MP0005387_immune_system_phenotype2.30406139
23MP0002420_abnormal_adaptive_immunity2.20583137
24MP0001819_abnormal_immune_cell2.19503350
25MP0003279_aneurysm2.19286726
26MP0005023_abnormal_wound_healing2.18994414
27MP0002148_abnormal_hypersensitivity_rea2.16485939
28MP0002419_abnormal_innate_immunity2.11450040
29MP0002452_abnormal_antigen_presenting2.06201837
30MP0006082_CNS_inflammation2.05838010
31MP0005623_abnormal_meninges_morphology2.03639336
32MP0009384_cardiac_valve_regurgitation2.02232787
33MP0001542_abnormal_bone_strength1.97354876
34MP0003566_abnormal_cell_adhesion1.91776657
35MP0010030_abnormal_orbit_morphology1.91438146
36MP0003950_abnormal_plasma_membrane1.87685976
37MP0004947_skin_inflammation1.86788792
38MP0003191_abnormal_cellular_cholesterol1.86305410
39MP0005085_abnormal_gallbladder_physiolo1.85859356
40MP0010352_gastrointestinal_tract_polyps1.85840845
41MP0002405_respiratory_system_inflammati1.85225478
42MP0003300_gastrointestinal_ulcer1.84065523
43MP0001958_emphysema1.81691107
44MP0003303_peritoneal_inflammation1.80733381
45MP0000465_gastrointestinal_hemorrhage1.78892753
46MP0002398_abnormal_bone_marrow1.77974497
47MP0004145_abnormal_muscle_electrophysio1.76287471
48MP0003045_fibrosis1.73973828
49MP0010155_abnormal_intestine_physiology1.72550946
50MP0000716_abnormal_immune_system1.71126251
51MP0003866_abnormal_defecation1.70947574
52MP0004272_abnormal_basement_membrane1.69756943
53MP0002166_altered_tumor_susceptibility1.68548548
54MP0000703_abnormal_thymus_morphology1.65655043
55MP0005332_abnormal_amino_acid1.58041064
56MP0002060_abnormal_skin_morphology1.55415535
57MP0002722_abnormal_immune_system1.53501918
58MP0002295_abnormal_pulmonary_circulatio1.50878951
59MP0005365_abnormal_bile_salt1.50561633
60MP0001873_stomach_inflammation1.48166297
61MP0003195_calcinosis1.48046094
62MP0000689_abnormal_spleen_morphology1.44417288
63MP0001845_abnormal_inflammatory_respons1.44308253
64MP0004510_myositis1.42447346
65MP0005464_abnormal_platelet_physiology1.39991602
66MP0000858_altered_metastatic_potential1.39264908
67MP0003186_abnormal_redox_activity1.37179380
68MP0004084_abnormal_cardiac_muscle1.34842523
69MP0002429_abnormal_blood_cell1.34661699
70MP0002998_abnormal_bone_remodeling1.33840259
71MP0000749_muscle_degeneration1.28175546
72MP0000733_abnormal_muscle_development1.26278309
73MP0000750_abnormal_muscle_regeneration1.24754312
74MP0001851_eye_inflammation1.24253455
75MP0004957_abnormal_blastocyst_morpholog1.24163493
76MP0005330_cardiomyopathy1.22264679
77MP0008469_abnormal_protein_level1.21834505
78MP0005508_abnormal_skeleton_morphology1.19727481
79MP0002009_preneoplasia1.18867999
80MP0005451_abnormal_body_composition1.18684227
81MP0001243_abnormal_dermal_layer1.17166129
82MP0002269_muscular_atrophy1.16333160
83MP0004381_abnormal_hair_follicle1.15181516
84MP0005670_abnormal_white_adipose1.12671079
85MP0002106_abnormal_muscle_physiology1.11500331
86MP0002877_abnormal_melanocyte_morpholog1.11476835
87MP0003448_altered_tumor_morphology1.11110458
88MP0004233_abnormal_muscle_weight1.10079111
89MP0008875_abnormal_xenobiotic_pharmacok1.05954650
90MP0000747_muscle_weakness1.05421437
91MP0001346_abnormal_lacrimal_gland1.04780536
92MP0004019_abnormal_vitamin_homeostasis1.04532035
93MP0003091_abnormal_cell_migration1.04116116
94MP0001666_abnormal_nutrient_absorption1.02500961
95MP0000762_abnormal_tongue_morphology1.01869757
96MP0005666_abnormal_adipose_tissue1.01513843
97MP0005075_abnormal_melanosome_morpholog1.01361175
98MP0000751_myopathy1.01082223
99MP0002006_tumorigenesis1.00613867
100MP0004087_abnormal_muscle_fiber0.99469578
101MP0003252_abnormal_bile_duct0.99282956
102MP0010329_abnormal_lipoprotein_level0.98896961
103MP0005257_abnormal_intraocular_pressure0.97558346
104MP0003693_abnormal_embryo_hatching0.94567308
105MP0009250_abnormal_appendicular_skeleto0.93643480
106MP0003878_abnormal_ear_physiology0.92745164
107MP0005377_hearing/vestibular/ear_phenot0.92745164
108MP0003453_abnormal_keratinocyte_physiol0.92552434
109MP0002108_abnormal_muscle_morphology0.91575679
110MP0008932_abnormal_embryonic_tissue0.90448200
111MP0009278_abnormal_bone_marrow0.90233834
112MP0004185_abnormal_adipocyte_glucose0.89850213
113MP0002138_abnormal_hepatobiliary_system0.89003504
114MP0009763_increased_sensitivity_to0.88873698
115MP0005395_other_phenotype0.88415944
116MP0005310_abnormal_salivary_gland0.88346847
117MP0005083_abnormal_biliary_tract0.86738172
118MP0005369_muscle_phenotype0.86555267
119MP0005166_decreased_susceptibility_to0.86429384
120MP0002254_reproductive_system_inflammat0.86172923
121MP0003795_abnormal_bone_structure0.85875390
122MP0005319_abnormal_enzyme/_coenzyme0.85690558
123MP0001661_extended_life_span0.85372985
124MP0000013_abnormal_adipose_tissue0.84345473
125MP0008260_abnormal_autophagy0.84029835
126MP0002168_other_aberrant_phenotype0.83936880
127MP0003718_maternal_effect0.83819994
128MP0009764_decreased_sensitivity_to0.82138701
129MP0000609_abnormal_liver_physiology0.81962215
130MP0006138_congestive_heart_failure0.81507192
131MP0001299_abnormal_eye_distance/0.77311633
132MP0005165_increased_susceptibility_to0.76567318
133MP0004130_abnormal_muscle_cell0.76081168
134MP0009643_abnormal_urine_homeostasis0.75965648
135MP0001348_abnormal_lacrimal_gland0.75837196
136MP0000759_abnormal_skeletal_muscle0.75716960
137MP0000003_abnormal_adipose_tissue0.75277269
138MP0002118_abnormal_lipid_homeostasis0.75035955
139MP0000249_abnormal_blood_vessel0.74736392
140MP0000598_abnormal_liver_morphology0.73409165
141MP0000377_abnormal_hair_follicle0.73043886
142MP0005375_adipose_tissue_phenotype0.72620713
143MP0002933_joint_inflammation0.72333131
144MP0008775_abnormal_heart_ventricle0.72083253
145MP0000627_abnormal_mammary_gland0.71953827
146MP0003075_altered_response_to0.71597507
147MP0005390_skeleton_phenotype0.70870636
148MP0001533_abnormal_skeleton_physiology0.69329215
149MP0002796_impaired_skin_barrier0.69103860
150MP0001853_heart_inflammation0.69085598
151MP0003221_abnormal_cardiomyocyte_apopto0.68521137
152MP0000767_abnormal_smooth_muscle0.67805000
153MP0004036_abnormal_muscle_relaxation0.67763263
154MP0000343_altered_response_to0.67428600
155MP0003646_muscle_fatigue0.67280394
156MP0002896_abnormal_bone_mineralization0.67265817
157MP0000467_abnormal_esophagus_morphology0.67186253
158MP0005058_abnormal_lysosome_morphology0.64617083
159MP0003828_pulmonary_edema0.63532416
160MP0003941_abnormal_skin_development0.63496448
161MP0004134_abnormal_chest_morphology0.63241753
162MP0009053_abnormal_anal_canal0.63071581
163MP0002133_abnormal_respiratory_system0.63068677
164MP0005388_respiratory_system_phenotype0.63068677
165MP0000163_abnormal_cartilage_morphology0.62713911
166MP0002111_abnormal_tail_morphology0.61703781
167MP0001544_abnormal_cardiovascular_syste0.61458603
168MP0005385_cardiovascular_system_phenoty0.61458603
169MP0010630_abnormal_cardiac_muscle0.60767837

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.47289272
2Protrusio acetabuli (HP:0003179)5.66097132
3Muscle fiber inclusion bodies (HP:0100299)4.79409953
4Nemaline bodies (HP:0003798)4.70288156
5Eczematoid dermatitis (HP:0000976)4.67211680
6T lymphocytopenia (HP:0005403)4.49658397
7Exercise-induced myalgia (HP:0003738)4.41869593
8Myositis (HP:0100614)4.31703563
9Abnormality of T cell number (HP:0011839)4.02482170
10Vertebral compression fractures (HP:0002953)3.98763211
11Orchitis (HP:0100796)3.90106790
12Optic neuritis (HP:0100653)3.78351475
13Retrobulbar optic neuritis (HP:0100654)3.78351475
14Centrally nucleated skeletal muscle fibers (HP:0003687)3.51977500
15Ankle contracture (HP:0006466)3.48800870
16IgG deficiency (HP:0004315)3.37675406
17Muscle fiber splitting (HP:0003555)3.35897352
18Biconcave vertebral bodies (HP:0004586)3.33833059
19Abnormality of skeletal muscle fiber size (HP:0012084)3.18501779
20Recurrent abscess formation (HP:0002722)3.16711222
21Abnormality of T cells (HP:0002843)3.16587446
22Xanthomatosis (HP:0000991)3.13754227
23Elevated erythrocyte sedimentation rate (HP:0003565)3.12169584
24Peritonitis (HP:0002586)3.11614147
25Abnormality of macrophages (HP:0004311)3.07923629
26Stomatitis (HP:0010280)3.07608212
27Increased connective tissue (HP:0009025)3.07394191
28EMG: myopathic abnormalities (HP:0003458)3.05153965
29Severe combined immunodeficiency (HP:0004430)3.04979985
30Abnormality of glycine metabolism (HP:0010895)3.03745616
31Abnormality of serine family amino acid metabolism (HP:0010894)3.03745616
32Abnormal delivery (HP:0001787)3.03002391
33Shallow orbits (HP:0000586)3.01165182
34Abnormality of eosinophils (HP:0001879)2.99848970
35Granulocytopenia (HP:0001913)2.99657199
36Hydroxyprolinuria (HP:0003080)2.97618942
37Abnormality of proline metabolism (HP:0010907)2.97618942
38Abnormality of the umbilical cord (HP:0010881)2.97409562
39Pustule (HP:0200039)2.96666747
40Cerebral hypomyelination (HP:0006808)2.93739458
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93099024
42Rhabdomyolysis (HP:0003201)2.92818388
43Soft skin (HP:0000977)2.87678745
44Increased variability in muscle fiber diameter (HP:0003557)2.82501884
45Wormian bones (HP:0002645)2.82383262
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82352467
47Hyperglycinuria (HP:0003108)2.82013498
48Cervical subluxation (HP:0003308)2.80146220
49Gastrointestinal infarctions (HP:0005244)2.80019521
50Ileus (HP:0002595)2.77924801
51Atrophic scars (HP:0001075)2.76111588
52Beaking of vertebral bodies (HP:0004568)2.75781650
53Eosinophilia (HP:0001880)2.75198573
54Recurrent bacterial skin infections (HP:0005406)2.75131054
55Recurrent fungal infections (HP:0002841)2.74540424
56Increased IgE level (HP:0003212)2.74472789
57Prolonged neonatal jaundice (HP:0006579)2.72438736
58Asymmetric septal hypertrophy (HP:0001670)2.67016627
59Neck muscle weakness (HP:0000467)2.66999808
60Encephalitis (HP:0002383)2.66619777
61Broad metatarsal (HP:0001783)2.63485847
62Meningitis (HP:0001287)2.61133207
63Gastrointestinal stroma tumor (HP:0100723)2.60604677
64Ulnar deviation of the wrist (HP:0003049)2.58744905
65Mediastinal lymphadenopathy (HP:0100721)2.58554153
66Keratoconjunctivitis sicca (HP:0001097)2.57484192
67Hypoalphalipoproteinemia (HP:0003233)2.55981354
68Leukocytosis (HP:0001974)2.54090559
69Aortic dissection (HP:0002647)2.53871605
70Right ventricular cardiomyopathy (HP:0011663)2.52974932
71Vasculitis (HP:0002633)2.50300927
72Pulmonary infiltrates (HP:0002113)2.50074661
73Keratoconjunctivitis (HP:0001096)2.49800909
74Hyperlipoproteinemia (HP:0010980)2.49587886
75Hyperammonemia (HP:0001987)2.49206969
76Ragged-red muscle fibers (HP:0003200)2.45379479
77Blue sclerae (HP:0000592)2.45110835
78Osteolytic defects of the hand bones (HP:0009699)2.42776373
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.42776373
80Combined immunodeficiency (HP:0005387)2.42432109
81Spinal rigidity (HP:0003306)2.42330779
82Distal arthrogryposis (HP:0005684)2.42062628
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41906121
84Bulbar palsy (HP:0001283)2.41733610
85Increased IgM level (HP:0003496)2.40919269
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.40194196
87Hyperglycinemia (HP:0002154)2.39345889
88Type 1 muscle fiber predominance (HP:0003803)2.38988627
89Colitis (HP:0002583)2.38416535
90Breech presentation (HP:0001623)2.38283293
91Intrahepatic cholestasis (HP:0001406)2.37397929
92Chronic obstructive pulmonary disease (HP:0006510)2.36749483
93Obstructive lung disease (HP:0006536)2.36749483
94Abnormality of fatty-acid metabolism (HP:0004359)2.30911706
95Persistence of primary teeth (HP:0006335)2.30347576
96Inflammation of the large intestine (HP:0002037)2.29501944
97Difficulty climbing stairs (HP:0003551)2.26623670
98Chronic mucocutaneous candidiasis (HP:0002728)2.24378131
99Recurrent cutaneous fungal infections (HP:0011370)2.24378131
100Hypolipoproteinemia (HP:0010981)2.24364796
101Recurrent bronchitis (HP:0002837)2.23931640
102Gastrointestinal inflammation (HP:0004386)2.23840837
103Abnormality of T cell physiology (HP:0011840)2.22948840
104Exercise-induced muscle cramps (HP:0003710)2.21828053
105Fragile skin (HP:0001030)2.21596788
106Abnormality of the fetal cardiovascular system (HP:0010948)2.20091643
107Abnormal umbilical cord blood vessels (HP:0011403)2.20091643
108Single umbilical artery (HP:0001195)2.20091643
109Wrist flexion contracture (HP:0001239)2.20067152
110Myoglobinuria (HP:0002913)2.19073738
111Myocardial infarction (HP:0001658)2.18167429
112IgM deficiency (HP:0002850)2.17970663
113Dysostosis multiplex (HP:0000943)2.17903168
114Recurrent viral infections (HP:0004429)2.16911260
115Abnormal cartilage morphology (HP:0002763)2.16896196
116Panhypogammaglobulinemia (HP:0003139)2.16513050
117Arterial thrombosis (HP:0004420)2.16225367
118Cerebral aneurysm (HP:0004944)2.13525346
119Chest pain (HP:0100749)2.10691773
120Abnormality of serum amino acid levels (HP:0003112)2.09709621
121Muscle stiffness (HP:0003552)2.09269406
122Aortic aneurysm (HP:0004942)2.09170262
123Nonimmune hydrops fetalis (HP:0001790)2.07571030
124Increased serum ferritin (HP:0003281)2.06762251
125Genu recurvatum (HP:0002816)2.06559718
126Gingivitis (HP:0000230)2.05971366
127Abnormality of the acetabulum (HP:0003170)2.05956691
128Cardiovascular calcification (HP:0011915)2.04484766
129Fatigue (HP:0012378)2.04277484
130Abnormality of glycolipid metabolism (HP:0010969)2.03996823
131Abnormality of liposaccharide metabolism (HP:0010968)2.03996823
132Abnormality of glycosphingolipid metabolism (HP:0004343)2.03996823
133Hemoptysis (HP:0002105)2.03694994
134Abnormality of dentin (HP:0010299)2.03542587
135Distal lower limb amyotrophy (HP:0008944)2.02958457
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02954369
137Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01780006
138Dicarboxylic aciduria (HP:0003215)2.01780006
139Short nail (HP:0001799)2.01501480
140Muscle hypertrophy of the lower extremities (HP:0008968)2.00741768
141Multiple enchondromatosis (HP:0005701)1.99523259
142Mildly elevated creatine phosphokinase (HP:0008180)1.99360731
143Urticaria (HP:0001025)1.99247958
144Esophageal neoplasm (HP:0100751)1.98822858
145Neoplasm of head and neck (HP:0012288)1.98822858
146Recurrent skin infections (HP:0001581)1.98608267
147Carpal bone hypoplasia (HP:0001498)1.98187283
148Autoimmune hemolytic anemia (HP:0001890)1.97263105
149Abnormality of the Achilles tendon (HP:0005109)1.96433307
150Round ear (HP:0100830)1.95793780
151Areflexia of lower limbs (HP:0002522)1.94279263
152Lymphopenia (HP:0001888)1.93602474
153Deep venous thrombosis (HP:0002625)1.93235091
154Anorexia (HP:0002039)1.91367995
155Dilatation of the ascending aorta (HP:0005111)1.91296466
156Generalized amyotrophy (HP:0003700)1.90236192
157Trismus (HP:0000211)1.89575747
158Hypobetalipoproteinemia (HP:0003563)1.89313656
159Difficulty running (HP:0009046)1.89214005
160Achilles tendon contracture (HP:0001771)1.87967122
161Polyneuropathy (HP:0001271)1.87644330
162Axonal loss (HP:0003447)1.87638801
163Elbow flexion contracture (HP:0002987)1.87183248
164Hypergammaglobulinemia (HP:0010702)1.87152150
165Spontaneous hematomas (HP:0007420)1.87106288
166Follicular hyperkeratosis (HP:0007502)1.86608944
167Neonatal short-limb short stature (HP:0008921)1.86550849
168Knee flexion contracture (HP:0006380)1.85393972
169Joint swelling (HP:0001386)1.85084464
170Agammaglobulinemia (HP:0004432)1.82796134
171Progressive muscle weakness (HP:0003323)1.82604314
172Myopathic facies (HP:0002058)1.82392282
173Distal lower limb muscle weakness (HP:0009053)1.81346540
174Hyperextensible skin (HP:0000974)1.79562493
175Ureteral duplication (HP:0000073)1.77685060
176Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77344498
177Bell-shaped thorax (HP:0001591)1.76764881
178Hyporeflexia of lower limbs (HP:0002600)1.76629511
179Deformed tarsal bones (HP:0008119)1.76577700
180Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75917598
181Natal tooth (HP:0000695)1.74229311
182Cupped ribs (HP:0000887)1.74119397
183Calcaneovalgus deformity (HP:0001848)1.72355973
184Abnormalities of placenta or umbilical cord (HP:0001194)1.71923205
185Wide anterior fontanel (HP:0000260)1.70784137
186Bladder diverticulum (HP:0000015)1.70698111
187Rough bone trabeculation (HP:0100670)1.69880684
188Metaphyseal cupping (HP:0003021)1.67825938
189Delayed cranial suture closure (HP:0000270)1.67556317
190Platyspondyly (HP:0000926)1.67437953
191Abnormality of the distal phalanges of the toes (HP:0010182)1.66326610
192Fused cervical vertebrae (HP:0002949)1.65734178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.78217934
2MAP4K13.62386507
3TXK3.61935416
4BUB13.40885280
5BCKDK3.32631844
6TESK23.13977018
7NME22.86095648
8GRK62.71030291
9TTN2.65882292
10WEE12.57249820
11MAP3K142.37446302
12TRIB32.29813349
13EPHB12.25906000
14DDR22.17669269
15FES2.03124948
16EIF2AK12.01478787
17ERN11.99892160
18ZAP701.99746624
19RPS6KA41.97644015
20TAOK31.93195223
21ZAK1.89978024
22SIK11.86637894
23RIPK41.84398522
24JAK11.79527689
25PRPF4B1.70888555
26CSK1.69323179
27LATS21.66132465
28IKBKE1.65972254
29IRAK41.65267432
30TYK21.53253529
31TESK11.52887849
32MUSK1.47258003
33JAK31.46122632
34MAP3K131.45898055
35LIMK11.43137303
36PIM21.41845842
37PDK21.41712814
38MET1.40741166
39MAP3K111.38298128
40SIK31.29127604
41PAK41.25129884
42BTK1.23696224
43SYK1.19705349
44MAPK111.19118493
45STK38L1.17459945
46LCK1.17027182
47MAP3K31.15393996
48STK391.15272118
49RPS6KB21.14142819
50NEK11.13739338
51NEK91.13323408
52PIK3CA1.13303583
53ITK1.12597166
54PDGFRA1.11597578
55PDK31.10959967
56PDK41.10959967
57EPHA31.10575655
58HCK1.09948509
59FGFR41.08923357
60SMG11.08804140
61MAP3K81.08329450
62ABL21.07276181
63MAP3K71.06403830
64MATK1.05571213
65LATS11.04999722
66TTK1.04070277
67BLK1.02153426
68MAPK121.00958781
69NME11.00338629
70PHKG20.97165220
71PHKG10.97165220
72MYLK0.96937756
73KIT0.96549529
74BRSK20.95812760
75MST40.95249244
76TLK10.93842650
77ILK0.93384062
78FER0.91594945
79TSSK60.91468145
80PKN20.90978436
81DAPK30.90857481
82MARK30.90188568
83RIPK10.90129412
84PAK20.89060827
85KDR0.88804508
86PAK10.88221297
87PRKCQ0.86985166
88TNK20.84009989
89MAPKAPK30.83984625
90MAP3K10.82718744
91MAP2K30.80951407
92MAPK70.80212807
93MAP2K20.79172162
94LRRK20.78507331
95LYN0.78244834
96PRKD20.76262970
97NUAK10.75403677
98RPS6KC10.75242493
99RPS6KL10.75242493
100PIK3CG0.75216319
101EIF2AK30.74596611
102ARAF0.74497810
103MAPKAPK50.74083008
104CLK10.70732588
105PTK20.69495055
106TBK10.69333087
107TAOK10.69323791
108PAK30.68544737
109PRKD10.67759327
110RPS6KA50.67307377
111MTOR0.65955501
112STK100.65932629
113TRPM70.64487448
114CAMK2G0.64477699
115RPS6KA60.64430693
116JAK20.64356174
117HIPK20.63297565
118PTK60.61262154
119RPS6KA20.60336245
120CDC42BPA0.58877556
121MARK20.58579784
122PDK10.57602845
123STK30.57056809
124GSK3A0.56173145
125CAMK2D0.56020642
126DYRK30.55732330
127MAPK40.55423256
128PIM10.54758719
129AURKA0.54638464
130FGFR10.52857843
131CHUK0.52154969
132DMPK0.52082311
133PLK10.51037060
134NLK0.50027173
135FGFR20.49590192
136BMX0.49375814
137AURKB0.48917254
138PDPK10.48602240
139BMPR20.48260265
140ROCK20.48112300
141NEK20.47599054
142PRKG20.47042582
143SCYL20.46192981
144IRAK10.45965906
145TGFBR20.45581685
146SIK20.44780528
147IRAK30.44365597
148TEC0.44145122
149IKBKB0.42404135
150TAOK20.42310020
151OBSCN0.41833697
152PINK10.41118450
153FGFR30.40043235
154CDK40.39671671
155KSR20.37269576
156PKN10.36816425
157MAP2K10.36072878
158RPS6KA10.35509938
159CDK60.35422992
160MAP3K60.34788923
161DYRK1B0.34765259
162FLT30.34241914
163PBK0.34237308
164MAPKAPK20.33212612

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.49922502
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.06882662
3T cell receptor signaling pathway_Homo sapiens_hsa046602.80422892
4Graft-versus-host disease_Homo sapiens_hsa053322.77344803
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.46142380
6Allograft rejection_Homo sapiens_hsa053302.44192012
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42212215
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41878652
9Vitamin B6 metabolism_Homo sapiens_hsa007502.41584511
10Osteoclast differentiation_Homo sapiens_hsa043802.38265362
11Autoimmune thyroid disease_Homo sapiens_hsa053202.36433465
12B cell receptor signaling pathway_Homo sapiens_hsa046622.26218334
13Nitrogen metabolism_Homo sapiens_hsa009102.25574465
14Folate biosynthesis_Homo sapiens_hsa007902.21879684
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21488185
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19273241
17Antigen processing and presentation_Homo sapiens_hsa046122.13379364
18Proteasome_Homo sapiens_hsa030502.10795161
19Measles_Homo sapiens_hsa051622.07409194
20Leishmaniasis_Homo sapiens_hsa051402.01949770
21Viral myocarditis_Homo sapiens_hsa054162.01853354
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01019779
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.97682576
24Caffeine metabolism_Homo sapiens_hsa002321.97256462
25Fatty acid degradation_Homo sapiens_hsa000711.91295068
26Acute myeloid leukemia_Homo sapiens_hsa052211.88937421
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86217544
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83503989
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79815624
30Sulfur metabolism_Homo sapiens_hsa009201.77835053
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73242550
32Other glycan degradation_Homo sapiens_hsa005111.67779924
33Hematopoietic cell lineage_Homo sapiens_hsa046401.65693526
34Arginine and proline metabolism_Homo sapiens_hsa003301.63972858
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.63384871
36Malaria_Homo sapiens_hsa051441.62404516
37Arginine biosynthesis_Homo sapiens_hsa002201.62250331
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61858724
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59338286
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58285207
41Glutathione metabolism_Homo sapiens_hsa004801.57996338
42Carbon metabolism_Homo sapiens_hsa012001.56691303
43Biosynthesis of amino acids_Homo sapiens_hsa012301.54034015
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53785809
45Propanoate metabolism_Homo sapiens_hsa006401.53509663
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51158884
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.50892438
48TNF signaling pathway_Homo sapiens_hsa046681.49856445
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.48531102
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47563436
51ECM-receptor interaction_Homo sapiens_hsa045121.44263162
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43986309
53Peroxisome_Homo sapiens_hsa041461.43861379
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43754493
55Fatty acid metabolism_Homo sapiens_hsa012121.43166416
56Pentose phosphate pathway_Homo sapiens_hsa000301.42927711
57Herpes simplex infection_Homo sapiens_hsa051681.42428194
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41857960
59Fatty acid elongation_Homo sapiens_hsa000621.38690365
60Shigellosis_Homo sapiens_hsa051311.37468242
61Staphylococcus aureus infection_Homo sapiens_hsa051501.37302661
62Tryptophan metabolism_Homo sapiens_hsa003801.36387696
63PPAR signaling pathway_Homo sapiens_hsa033201.32817130
64Toxoplasmosis_Homo sapiens_hsa051451.32549969
65Type I diabetes mellitus_Homo sapiens_hsa049401.29956927
66Apoptosis_Homo sapiens_hsa042101.29834599
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29230166
68Sulfur relay system_Homo sapiens_hsa041221.27369247
69Chemical carcinogenesis_Homo sapiens_hsa052041.26021470
70Histidine metabolism_Homo sapiens_hsa003401.22806114
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.22219184
72Adipocytokine signaling pathway_Homo sapiens_hsa049201.22134898
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21559300
74beta-Alanine metabolism_Homo sapiens_hsa004101.20468821
75One carbon pool by folate_Homo sapiens_hsa006701.18285236
76Galactose metabolism_Homo sapiens_hsa000521.17709466
77Chemokine signaling pathway_Homo sapiens_hsa040621.16134147
78Fat digestion and absorption_Homo sapiens_hsa049751.16108637
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14993282
80Drug metabolism - other enzymes_Homo sapiens_hsa009831.14793150
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13874216
82Cysteine and methionine metabolism_Homo sapiens_hsa002701.13018199
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12153352
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10668853
85Influenza A_Homo sapiens_hsa051641.10268714
86Pyruvate metabolism_Homo sapiens_hsa006201.09227398
87Tuberculosis_Homo sapiens_hsa051521.08444418
88Vitamin digestion and absorption_Homo sapiens_hsa049771.07344779
89Leukocyte transendothelial migration_Homo sapiens_hsa046701.06996623
90Selenocompound metabolism_Homo sapiens_hsa004501.05524132
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04998962
92Butanoate metabolism_Homo sapiens_hsa006501.03005968
93Complement and coagulation cascades_Homo sapiens_hsa046101.02864761
94Hepatitis C_Homo sapiens_hsa051600.97363498
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96724841
96HTLV-I infection_Homo sapiens_hsa051660.96209664
97Rheumatoid arthritis_Homo sapiens_hsa053230.95803808
98Asthma_Homo sapiens_hsa053100.94740756
99VEGF signaling pathway_Homo sapiens_hsa043700.94289960
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.93776387
101Lysosome_Homo sapiens_hsa041420.91381059
102Non-small cell lung cancer_Homo sapiens_hsa052230.90947825
103Fructose and mannose metabolism_Homo sapiens_hsa000510.89913502
104Hepatitis B_Homo sapiens_hsa051610.89782958
105RNA polymerase_Homo sapiens_hsa030200.89015848
106Retinol metabolism_Homo sapiens_hsa008300.87402957
107p53 signaling pathway_Homo sapiens_hsa041150.84811811
108Viral carcinogenesis_Homo sapiens_hsa052030.84432993
109Epstein-Barr virus infection_Homo sapiens_hsa051690.82162517
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81531843
111Ribosome_Homo sapiens_hsa030100.80842569
112Steroid biosynthesis_Homo sapiens_hsa001000.80473121
113DNA replication_Homo sapiens_hsa030300.80270721
114Starch and sucrose metabolism_Homo sapiens_hsa005000.80012878
115RNA transport_Homo sapiens_hsa030130.78981313
116Legionellosis_Homo sapiens_hsa051340.78931176
117Pertussis_Homo sapiens_hsa051330.78320265
118Pancreatic cancer_Homo sapiens_hsa052120.77942573
119Focal adhesion_Homo sapiens_hsa045100.75995747
120Endocytosis_Homo sapiens_hsa041440.74905992
121Protein digestion and absorption_Homo sapiens_hsa049740.73427629
122Chronic myeloid leukemia_Homo sapiens_hsa052200.73308194
123Small cell lung cancer_Homo sapiens_hsa052220.70209137
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69973764
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69796570
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68141657
127Salmonella infection_Homo sapiens_hsa051320.67802815
128Pyrimidine metabolism_Homo sapiens_hsa002400.64507025
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64492753
130Platelet activation_Homo sapiens_hsa046110.62672831
131Regulation of autophagy_Homo sapiens_hsa041400.62539690
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62223526
133Protein export_Homo sapiens_hsa030600.61184444
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60025169
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59308693
136Insulin signaling pathway_Homo sapiens_hsa049100.59009948
137Renin-angiotensin system_Homo sapiens_hsa046140.58105724
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58081883
139Glycerolipid metabolism_Homo sapiens_hsa005610.57289239
140Arachidonic acid metabolism_Homo sapiens_hsa005900.55971989
141Tight junction_Homo sapiens_hsa045300.54688080
142Prolactin signaling pathway_Homo sapiens_hsa049170.54535359
143Dilated cardiomyopathy_Homo sapiens_hsa054140.53854001
144Metabolic pathways_Homo sapiens_hsa011000.52621377
145Amoebiasis_Homo sapiens_hsa051460.51794675
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51200771
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50720017
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50719277
149Linoleic acid metabolism_Homo sapiens_hsa005910.49565393
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.48137235
151Bladder cancer_Homo sapiens_hsa052190.46678212
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45299541
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.45193879
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45028515
155Cell cycle_Homo sapiens_hsa041100.44560832
156MAPK signaling pathway_Homo sapiens_hsa040100.44053074
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43114421
158Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42520914
159Nucleotide excision repair_Homo sapiens_hsa034200.42135741
160Phenylalanine metabolism_Homo sapiens_hsa003600.40916004
161Prion diseases_Homo sapiens_hsa050200.39882957
162Adherens junction_Homo sapiens_hsa045200.39697654
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39666123
164TGF-beta signaling pathway_Homo sapiens_hsa043500.39097809
165Mismatch repair_Homo sapiens_hsa034300.38847965
166African trypanosomiasis_Homo sapiens_hsa051430.38750124
167Insulin resistance_Homo sapiens_hsa049310.37123579
168Base excision repair_Homo sapiens_hsa034100.36801955
169mTOR signaling pathway_Homo sapiens_hsa041500.36131466
170Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34487670
171Phagosome_Homo sapiens_hsa041450.34393585
172Systemic lupus erythematosus_Homo sapiens_hsa053220.31876643
173Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31752496
174Notch signaling pathway_Homo sapiens_hsa043300.30940503
175Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30300727
176Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29869453
177Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29397757
178Thyroid cancer_Homo sapiens_hsa052160.29201604
179Sphingolipid signaling pathway_Homo sapiens_hsa040710.26434009
180HIF-1 signaling pathway_Homo sapiens_hsa040660.26006776
181SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23785070
182FoxO signaling pathway_Homo sapiens_hsa040680.22069102
183Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20014782

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »