PLEKHF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.89019459
2neutrophil activation involved in immune response (GO:0002283)4.24626753
3response to peptidoglycan (GO:0032494)4.24224847
4nuclear pore organization (GO:0006999)4.22950785
5mitotic metaphase plate congression (GO:0007080)4.19566236
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.13390470
7modulation by symbiont of host immune response (GO:0052553)4.13390470
8positive regulation by symbiont of host defense response (GO:0052509)4.13390470
9modulation by symbiont of host defense response (GO:0052031)4.13390470
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13390470
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13390470
12regulation of interferon-beta biosynthetic process (GO:0045357)3.97607406
13immunoglobulin mediated immune response (GO:0016064)3.96412880
14B cell receptor signaling pathway (GO:0050853)3.96266542
15regulation of B cell receptor signaling pathway (GO:0050855)3.91096955
16nuclear pore complex assembly (GO:0051292)3.82561433
17macrophage activation involved in immune response (GO:0002281)3.78383978
18protein localization to kinetochore (GO:0034501)3.76066714
19nucleobase biosynthetic process (GO:0046112)3.75381981
20DNA replication initiation (GO:0006270)3.75127900
21purine nucleobase biosynthetic process (GO:0009113)3.67903022
22DNA replication checkpoint (GO:0000076)3.66491462
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66468760
24negative regulation of cell killing (GO:0031342)3.66468760
25regulation of gamma-delta T cell activation (GO:0046643)3.64681617
26mitotic nuclear envelope disassembly (GO:0007077)3.63587799
27DNA strand elongation involved in DNA replication (GO:0006271)3.62194245
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60891415
29regulation of helicase activity (GO:0051095)3.58802007
30detection of other organism (GO:0098543)3.54475277
31formation of translation preinitiation complex (GO:0001731)3.52618431
32germinal center formation (GO:0002467)3.51880558
33metaphase plate congression (GO:0051310)3.51157544
34antigen processing and presentation of endogenous antigen (GO:0019883)3.45869697
35ribosome assembly (GO:0042255)3.45477231
36DNA strand elongation (GO:0022616)3.44775718
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43400821
38positive regulation of B cell differentiation (GO:0045579)3.42244200
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.41410118
40regulation of mast cell degranulation (GO:0043304)3.38570931
41nuclear envelope disassembly (GO:0051081)3.36809503
42membrane disassembly (GO:0030397)3.36809503
43detection of bacterium (GO:0016045)3.36312553
44regulation of T-helper 2 cell differentiation (GO:0045628)3.34711059
45regulation of T-helper 1 cell differentiation (GO:0045625)3.34680837
46telomere maintenance via semi-conservative replication (GO:0032201)3.34077920
47protein localization to chromosome, centromeric region (GO:0071459)3.33399981
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32010061
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31994851
50IMP biosynthetic process (GO:0006188)3.30921032
51regulation of posttranscriptional gene silencing (GO:0060147)3.29720483
52regulation of gene silencing by miRNA (GO:0060964)3.29720483
53regulation of gene silencing by RNA (GO:0060966)3.29720483
54positive regulation of interferon-alpha production (GO:0032727)3.27587502
55response to muramyl dipeptide (GO:0032495)3.26687395
56ribosome biogenesis (GO:0042254)3.25198866
57maturation of SSU-rRNA (GO:0030490)3.24815547
58regulation of interferon-alpha production (GO:0032647)3.24607884
59ribosomal small subunit assembly (GO:0000028)3.23083806
60DNA unwinding involved in DNA replication (GO:0006268)3.19777958
61positive regulation of mast cell activation (GO:0033005)3.18521084
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.18428247
63regulation of gamma-delta T cell differentiation (GO:0045586)3.18208647
64negative regulation of interleukin-12 production (GO:0032695)3.17781566
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.17688412
66positive regulation of mast cell degranulation (GO:0043306)3.17688412
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16288575
68regulation of histone H3-K9 methylation (GO:0051570)3.14344313
69telomere maintenance via recombination (GO:0000722)3.13810121
70detection of molecule of bacterial origin (GO:0032490)3.13461672
71hepatocyte apoptotic process (GO:0097284)3.13066940
72folic acid-containing compound biosynthetic process (GO:0009396)3.12693249
73response to host immune response (GO:0052572)3.12480750
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12480750
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10778507
76DNA replication-dependent nucleosome organization (GO:0034723)3.10752972
77DNA replication-dependent nucleosome assembly (GO:0006335)3.10752972
78regulation of mast cell activation involved in immune response (GO:0033006)3.10414219
79production of molecular mediator involved in inflammatory response (GO:0002532)3.10148028
80establishment of chromosome localization (GO:0051303)3.08920613
81pore complex assembly (GO:0046931)3.08654996
82neutrophil activation (GO:0042119)3.08591343
83chromatin remodeling at centromere (GO:0031055)3.07797403
84detection of external biotic stimulus (GO:0098581)3.07669878
85defense response to protozoan (GO:0042832)3.07467363
86folic acid metabolic process (GO:0046655)3.06072004
87negative regulation of erythrocyte differentiation (GO:0045647)3.04658902
88response to protozoan (GO:0001562)3.04567824
89type I interferon signaling pathway (GO:0060337)3.02126604
90cellular response to type I interferon (GO:0071357)3.02126604
91CENP-A containing nucleosome assembly (GO:0034080)3.01606220
92kinetochore organization (GO:0051383)3.00581016
93T-helper 1 type immune response (GO:0042088)2.99840092
94positive regulation of leukocyte degranulation (GO:0043302)2.98845583
95attachment of spindle microtubules to kinetochore (GO:0008608)2.98835864
96mitotic recombination (GO:0006312)2.98220820
97granulocyte activation (GO:0036230)2.98138445
98IMP metabolic process (GO:0046040)2.98045458
99response to type I interferon (GO:0034340)2.97074180
100interferon-gamma-mediated signaling pathway (GO:0060333)2.96892839
101regulation of leukocyte degranulation (GO:0043300)2.96765485
102positive regulation of type 2 immune response (GO:0002830)2.94973633
103ribonucleoprotein complex biogenesis (GO:0022613)2.93948283
104regulation of spindle organization (GO:0090224)2.93402028
105DNA deamination (GO:0045006)2.92712284
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.92465858
107protein K6-linked ubiquitination (GO:0085020)2.92036692
108positive regulation of chromosome segregation (GO:0051984)2.91502205
109negative regulation of T-helper cell differentiation (GO:0045623)2.90695014
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90695014
111response to host (GO:0075136)2.89305006
112response to host defenses (GO:0052200)2.89305006
113response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89305006
114meiotic chromosome segregation (GO:0045132)2.86589764
115negative regulation of histone methylation (GO:0031061)2.86350848
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85827697
117regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85505413
118mitotic chromosome condensation (GO:0007076)2.84235856
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.83623111
120somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83623111
121DNA replication-independent nucleosome organization (GO:0034724)2.81881719
122DNA replication-independent nucleosome assembly (GO:0006336)2.81881719
123cellular extravasation (GO:0045123)2.81289932
124NIK/NF-kappaB signaling (GO:0038061)2.81100300
125ribosomal large subunit biogenesis (GO:0042273)2.79972984
126regulation of B cell differentiation (GO:0045577)2.79862504
127myeloid cell activation involved in immune response (GO:0002275)2.79770032
128telomere maintenance via telomere lengthening (GO:0010833)2.79241805
129leukocyte aggregation (GO:0070486)2.78904695
130mitotic sister chromatid segregation (GO:0000070)2.78844704
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77875949
132regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.76341670
133kinetochore assembly (GO:0051382)2.76330393
134positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75876445
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72473129
136B cell homeostasis (GO:0001782)2.70809939
137regulation of double-strand break repair via homologous recombination (GO:0010569)2.70437653
138regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.70313369
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70267354
140regulation of alpha-beta T cell proliferation (GO:0046640)2.69915761
141DNA duplex unwinding (GO:0032508)2.69763628
142DNA geometric change (GO:0032392)2.69549597
143positive thymic T cell selection (GO:0045059)2.67089088
144negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66648216
145positive regulation of mitotic sister chromatid separation (GO:1901970)2.65714504
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65714504
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65714504
148regulation of mast cell activation (GO:0033003)2.65702853
149detection of biotic stimulus (GO:0009595)2.65176237
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62426661
151nuclear envelope organization (GO:0006998)2.61945869
152macrophage activation (GO:0042116)2.61536461
153positive regulation of interferon-beta production (GO:0032728)2.61237888
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60481544
155regulation of antigen processing and presentation (GO:0002577)2.57889542
156T cell migration (GO:0072678)2.57836573
157B cell mediated immunity (GO:0019724)2.57518359
158viral transcription (GO:0019083)2.56951477
159histone exchange (GO:0043486)2.56392878
160regulation of gene silencing (GO:0060968)2.56289996
161regulation of translation in response to stress (GO:0043555)2.55743785
162histone H3-K36 demethylation (GO:0070544)2.55510788
163positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55174948
164regulation of hypersensitivity (GO:0002883)2.55143669
165translational termination (GO:0006415)2.55048639
166rRNA processing (GO:0006364)2.54308007
167translational initiation (GO:0006413)2.53919274
168nucleotide-excision repair, DNA gap filling (GO:0006297)2.53789750
169negative regulation of T cell mediated immunity (GO:0002710)2.52726385
170regulation of T-helper cell differentiation (GO:0045622)2.52697975
171B cell proliferation (GO:0042100)2.52059823
172adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.51286373
173positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.50907543
174regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.50636408
175positive regulation of interleukin-2 production (GO:0032743)2.50257286
176regulation of chromosome segregation (GO:0051983)2.50029027
177regulation of mitotic spindle organization (GO:0060236)2.49927392
178chromatin assembly or disassembly (GO:0006333)2.49032535
179sister chromatid segregation (GO:0000819)2.47926797
180rRNA metabolic process (GO:0016072)2.47631759
181telomere maintenance (GO:0000723)2.45994641
182ribosomal small subunit biogenesis (GO:0042274)2.45620397
183telomere organization (GO:0032200)2.45139263
184spindle checkpoint (GO:0031577)2.44522633
185determination of adult lifespan (GO:0008340)2.43750128
186regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43372223
187negative regulation of chromosome segregation (GO:0051985)2.42767847
188protein localization to chromosome (GO:0034502)2.42686350
189embryonic process involved in female pregnancy (GO:0060136)2.41873628
190interferon-gamma secretion (GO:0072643)2.41291259
191mismatch repair (GO:0006298)2.41201348
192negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.36369557
193negative regulation of sister chromatid segregation (GO:0033046)2.36369557
194negative regulation of mitotic sister chromatid separation (GO:2000816)2.36369557
195negative regulation of mitotic sister chromatid segregation (GO:0033048)2.36369557
196regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36223420
197translational elongation (GO:0006414)2.35963549
198chromosome segregation (GO:0007059)2.35854962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.03846805
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97199489
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.67249143
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.40840293
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14491553
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08886131
7GATA1_22025678_ChIP-Seq_K562_Human2.92942175
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87638331
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.82349461
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.77807015
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.69785357
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68477927
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68264269
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61176010
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52560286
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35376955
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20029478
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19812564
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18344089
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.15545232
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14235248
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14039451
23SCL_19346495_ChIP-Seq_HPC-7_Human2.12672738
24RUNX_20019798_ChIP-Seq_JUKART_Human2.11394039
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10420750
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08759808
27VDR_24763502_ChIP-Seq_THP-1_Human2.08663318
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01044859
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.00249055
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96321015
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96153028
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93346580
33MAF_26560356_Chip-Seq_TH1_Human1.92322739
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87269269
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.87136398
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.84721201
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84643018
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.84377861
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82353969
40AR_21909140_ChIP-Seq_LNCAP_Human1.78505863
41VDR_23849224_ChIP-Seq_CD4+_Human1.78297678
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76929406
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.76686311
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76068310
45TCF7_22412390_ChIP-Seq_EML_Mouse1.75653892
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75015031
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75000534
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73616773
49MYC_22102868_ChIP-Seq_BL_Human1.73324305
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72778948
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71851600
52XRN2_22483619_ChIP-Seq_HELA_Human1.71817795
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71635089
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71635089
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71635089
56SPI1_23127762_ChIP-Seq_K562_Human1.67874705
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65264201
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65147780
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.60764216
60* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60104089
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57845859
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56482594
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56399191
64UTX_26944678_Chip-Seq_JUKART_Human1.55174305
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55151883
66FOXP3_21729870_ChIP-Seq_TREG_Human1.50976792
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.49184873
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45514465
69PU_27001747_Chip-Seq_BMDM_Mouse1.44866268
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44623769
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43557009
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43141007
73VDR_24787735_ChIP-Seq_THP-1_Human1.42452139
74GATA3_27048872_Chip-Seq_THYMUS_Human1.41661592
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41573278
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40926039
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37143771
78* DCP1A_22483619_ChIP-Seq_HELA_Human1.33791300
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33289129
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33157056
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32747503
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.32415383
83GABP_19822575_ChIP-Seq_HepG2_Human1.32230511
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31897313
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31579252
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30720361
87* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30623039
88ELK1_19687146_ChIP-ChIP_HELA_Human1.30243598
89* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28513301
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28092296
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26762479
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26460257
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.25978091
94* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25556993
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25161202
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24999414
97TTF2_22483619_ChIP-Seq_HELA_Human1.24059206
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23959075
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22906989
100* TFEB_21752829_ChIP-Seq_HELA_Human1.22483034
101SPI1_23547873_ChIP-Seq_NB4_Human1.22192287
102KDM5A_27292631_Chip-Seq_BREAST_Human1.21849120
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21594982
104CIITA_25753668_ChIP-Seq_RAJI_Human1.21587093
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19739554
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.17872392
107* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17060610
108* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17014961
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16292359
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15340665
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14785757
112SALL1_21062744_ChIP-ChIP_HESCs_Human1.14245499
113* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14194425
114* ESR2_21235772_ChIP-Seq_MCF-7_Human1.14068830
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14000372
116MAF_26560356_Chip-Seq_TH2_Human1.13111339
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10452662
118VDR_21846776_ChIP-Seq_THP-1_Human1.10393918
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10232271
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10065667
121NCOR1_26117541_ChIP-Seq_K562_Human1.09082758
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08902343
123GATA1_19941826_ChIP-Seq_K562_Human1.08816217
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08528545
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.07005733
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06209628
127ZNF263_19887448_ChIP-Seq_K562_Human1.06133027
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05897850
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05797153
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05511566
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.03787382
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02672729
133FOXO3_23340844_ChIP-Seq_DLD1_Human1.02231475
134ELF5_23300383_ChIP-Seq_T47D_Human1.01644358
135GATA3_26560356_Chip-Seq_TH2_Human1.01620228
136GATA1_19941827_ChIP-Seq_MEL_Mouse1.01557703
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00676746
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.00590437
139* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00480891
140TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00293305
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99519099
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.99027906
143* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98730679
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97499332
145* MYB_26560356_Chip-Seq_TH1_Human0.97180482
146KDM2B_26808549_Chip-Seq_DND41_Human0.97143241
147SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97005871
148GATA2_19941826_ChIP-Seq_K562_Human0.96883816
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95439580
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95132747
151* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94913762
152THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94133925
153* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92987826
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92127076
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92127076
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92098164
157KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91999949
158MYB_26560356_Chip-Seq_TH2_Human0.91620671
159PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91510119
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91099071
161CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90877146
162* NANOG_21062744_ChIP-ChIP_HESCs_Human0.90785402
163BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90278873
164* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89639937
165MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89149969
166* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88741206
167NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88578599
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87616049
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87494323
170CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87410418
171NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87259802
172DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86471908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.31269837
2MP0003111_abnormal_nucleus_morphology3.42942201
3MP0010094_abnormal_chromosome_stability3.42616144
4MP0004957_abnormal_blastocyst_morpholog3.34326701
5MP0008057_abnormal_DNA_replication3.17227493
6MP0003077_abnormal_cell_cycle3.00663809
7MP0003724_increased_susceptibility_to2.79388116
8MP0010352_gastrointestinal_tract_polyps2.49518920
9MP0008058_abnormal_DNA_repair2.47534883
10MP0008007_abnormal_cellular_replicative2.22492006
11MP0010307_abnormal_tumor_latency2.13469931
12MP0002396_abnormal_hematopoietic_system2.07952638
13MP0005451_abnormal_body_composition2.03042609
14MP0000490_abnormal_crypts_of1.99815866
15MP0003300_gastrointestinal_ulcer1.98056773
16MP0001835_abnormal_antigen_presentation1.96586090
17MP0000350_abnormal_cell_proliferation1.86794414
18MP0003656_abnormal_erythrocyte_physiolo1.77150603
19MP0001873_stomach_inflammation1.77098220
20MP0001730_embryonic_growth_arrest1.77011989
21MP0001545_abnormal_hematopoietic_system1.68896730
22MP0005397_hematopoietic_system_phenotyp1.68896730
23MP0003786_premature_aging1.64940118
24MP0003183_abnormal_peptide_metabolism1.62554001
25MP0003436_decreased_susceptibility_to1.57576278
26MP0008260_abnormal_autophagy1.53959536
27MP0004808_abnormal_hematopoietic_stem1.50600256
28MP0005058_abnormal_lysosome_morphology1.50099549
29MP0005076_abnormal_cell_differentiation1.49448132
30MP0008932_abnormal_embryonic_tissue1.47774473
31MP0003806_abnormal_nucleotide_metabolis1.47382562
32MP0002796_impaired_skin_barrier1.46702334
33MP0005310_abnormal_salivary_gland1.41952005
34MP0002398_abnormal_bone_marrow1.41743393
35MP0004381_abnormal_hair_follicle1.40949222
36MP0009333_abnormal_splenocyte_physiolog1.40051857
37MP0005380_embryogenesis_phenotype1.39038781
38MP0001672_abnormal_embryogenesis/_devel1.39038781
39MP0001800_abnormal_humoral_immune1.38755870
40MP0002019_abnormal_tumor_incidence1.37636167
41MP0000685_abnormal_immune_system1.35640757
42MP0001533_abnormal_skeleton_physiology1.32359407
43MP0000689_abnormal_spleen_morphology1.32108802
44MP0009278_abnormal_bone_marrow1.31101061
45MP0002086_abnormal_extraembryonic_tissu1.31046839
46MP0003123_paternal_imprinting1.30027465
47MP0002722_abnormal_immune_system1.30014247
48MP0002452_abnormal_antigen_presenting1.27522730
49MP0009785_altered_susceptibility_to1.27461114
50MP0003186_abnormal_redox_activity1.27038486
51MP0002877_abnormal_melanocyte_morpholog1.26426881
52MP0003718_maternal_effect1.25378760
53MP0001697_abnormal_embryo_size1.25240928
54MP0000313_abnormal_cell_death1.25198596
55MP0009840_abnormal_foam_cell1.24657128
56MP0001853_heart_inflammation1.24501228
57MP0009764_decreased_sensitivity_to1.24460591
58MP0010678_abnormal_skin_adnexa1.24445400
59MP0003984_embryonic_growth_retardation1.24265557
60MP0002088_abnormal_embryonic_growth/wei1.21903009
61MP0003763_abnormal_thymus_physiology1.20225530
62MP0002166_altered_tumor_susceptibility1.18819542
63MP0002080_prenatal_lethality1.18200596
64MP0005025_abnormal_response_to1.17025010
65MP0005000_abnormal_immune_tolerance1.16078032
66MP0002006_tumorigenesis1.16063170
67MP0010155_abnormal_intestine_physiology1.15270553
68MP0001819_abnormal_immune_cell1.14689607
69MP0000716_abnormal_immune_system1.14444745
70MP0002723_abnormal_immune_serum1.14321801
71MP0002429_abnormal_blood_cell1.14237805
72MP0002420_abnormal_adaptive_immunity1.14215967
73MP0008004_abnormal_stomach_pH1.13272888
74MP0005671_abnormal_response_to1.12450782
75MP0002148_abnormal_hypersensitivity_rea1.11406794
76MP0003566_abnormal_cell_adhesion1.10612862
77MP0003941_abnormal_skin_development1.08532469
78MP0004197_abnormal_fetal_growth/weight/1.08162149
79MP0002405_respiratory_system_inflammati1.06219840
80MP0000858_altered_metastatic_potential1.06138977
81MP0002998_abnormal_bone_remodeling1.05856434
82MP0003172_abnormal_lysosome_physiology1.05309118
83MP0002132_abnormal_respiratory_system1.05120534
84MP0002085_abnormal_embryonic_tissue1.04565477
85MP0003828_pulmonary_edema1.04495115
86MP0002138_abnormal_hepatobiliary_system1.03042764
87MP0000703_abnormal_thymus_morphology1.03012611
88MP0001790_abnormal_immune_system1.03011496
89MP0005387_immune_system_phenotype1.03011496
90MP0003567_abnormal_fetal_cardiomyocyte1.02499037
91MP0003448_altered_tumor_morphology0.99823771
92MP0002419_abnormal_innate_immunity0.98951710
93MP0004947_skin_inflammation0.98642469
94MP0008877_abnormal_DNA_methylation0.98180618
95MP0002084_abnormal_developmental_patter0.97855991
96MP0001851_eye_inflammation0.97618638
97MP0000383_abnormal_hair_follicle0.97050038
98MP0001293_anophthalmia0.95733975
99MP0002009_preneoplasia0.92535784
100MP0003075_altered_response_to0.90260347
101MP0001216_abnormal_epidermal_layer0.90236937
102MP0004264_abnormal_extraembryonic_tissu0.89922789
103MP0003705_abnormal_hypodermis_morpholog0.89470666
104MP0003866_abnormal_defecation0.89355447
105MP0005166_decreased_susceptibility_to0.87271011
106MP0005464_abnormal_platelet_physiology0.86399703
107MP0004883_abnormal_blood_vessel0.85835427
108MP0001845_abnormal_inflammatory_respons0.85321216
109MP0003191_abnormal_cellular_cholesterol0.84287607
110MP0003303_peritoneal_inflammation0.83868463
111MP0003091_abnormal_cell_migration0.83272370
112MP0000371_diluted_coat_color0.82998127
113MP0002139_abnormal_hepatobiliary_system0.82601379
114MP0005023_abnormal_wound_healing0.80012782
115MP0003453_abnormal_keratinocyte_physiol0.79450199
116MP0000477_abnormal_intestine_morphology0.79312438
117MP0006082_CNS_inflammation0.78690943
118MP0000465_gastrointestinal_hemorrhage0.78633170
119MP0001727_abnormal_embryo_implantation0.78373333
120MP0010234_abnormal_vibrissa_follicle0.78008992
121MP0001915_intracranial_hemorrhage0.77774259
122MP0005164_abnormal_response_to0.76923363
123MP0002210_abnormal_sex_determination0.76289555
124MP0004185_abnormal_adipocyte_glucose0.76262185
125MP0004510_myositis0.75938682
126MP0000343_altered_response_to0.75287806
127MP0004782_abnormal_surfactant_physiolog0.74895585
128MP0003221_abnormal_cardiomyocyte_apopto0.74572624
129MP0005621_abnormal_cell_physiology0.74200815
130MP0002277_abnormal_respiratory_mucosa0.73444176
131MP0005501_abnormal_skin_physiology0.73360525
132MP0009763_increased_sensitivity_to0.72544697
133MP0000609_abnormal_liver_physiology0.72442197
134MP0001145_abnormal_male_reproductive0.72422173
135MP0005174_abnormal_tail_pigmentation0.69913634
136MP0008469_abnormal_protein_level0.68125846
137MP0005075_abnormal_melanosome_morpholog0.68103717
138MP0000015_abnormal_ear_pigmentation0.67609927
139MP0002332_abnormal_exercise_endurance0.67515721
140MP0002098_abnormal_vibrissa_morphology0.67261933
141MP0000249_abnormal_blood_vessel0.67162659

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.45780751
2Meningitis (HP:0001287)3.57074048
3Agnosia (HP:0010524)3.54851527
4Breast hypoplasia (HP:0003187)3.50852655
5Agammaglobulinemia (HP:0004432)3.41713976
6B lymphocytopenia (HP:0010976)3.40069420
7Reticulocytopenia (HP:0001896)3.34234688
8Panhypogammaglobulinemia (HP:0003139)3.29606607
9Abnormality of B cell number (HP:0010975)3.26730082
10Chromsome breakage (HP:0040012)3.25597745
11Vasculitis (HP:0002633)3.19229151
12Gastrointestinal stroma tumor (HP:0100723)3.14548052
13Recurrent bronchitis (HP:0002837)3.14305794
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13309635
15T lymphocytopenia (HP:0005403)3.12517207
16Myositis (HP:0100614)3.07995109
17Optic neuritis (HP:0100653)3.07240709
18Retrobulbar optic neuritis (HP:0100654)3.07240709
19Orchitis (HP:0100796)3.03845688
20Abnormality of the anterior horn cell (HP:0006802)3.01016203
21Degeneration of anterior horn cells (HP:0002398)3.01016203
22Colitis (HP:0002583)2.99428437
23Ependymoma (HP:0002888)2.98869310
24Recurrent gram-negative bacterial infections (HP:0005420)2.93007046
25Recurrent skin infections (HP:0001581)2.92498596
26Osteomyelitis (HP:0002754)2.91426303
27Impulsivity (HP:0100710)2.86750845
28Stomatitis (HP:0010280)2.86085733
29Abnormality of cells of the erythroid lineage (HP:0012130)2.86026407
30Carpal bone hypoplasia (HP:0001498)2.84948833
31Increased IgE level (HP:0003212)2.82722830
32Abnormality of chromosome stability (HP:0003220)2.80374311
33Loss of speech (HP:0002371)2.78165108
34Autoimmune hemolytic anemia (HP:0001890)2.75800066
35Gastrointestinal infarctions (HP:0005244)2.73909950
36Chronic obstructive pulmonary disease (HP:0006510)2.72465223
37Obstructive lung disease (HP:0006536)2.72465223
38Oral leukoplakia (HP:0002745)2.71750625
39Gastrointestinal inflammation (HP:0004386)2.71217510
40Inflammation of the large intestine (HP:0002037)2.71117555
41Abnormal number of erythroid precursors (HP:0012131)2.69917807
42Absent thumb (HP:0009777)2.66391345
43Prolonged bleeding time (HP:0003010)2.65610278
44Patellar aplasia (HP:0006443)2.64286687
45Abnormality of glycolipid metabolism (HP:0010969)2.63666902
46Abnormality of liposaccharide metabolism (HP:0010968)2.63666902
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.63666902
48Colon cancer (HP:0003003)2.63033966
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54861917
50Urticaria (HP:0001025)2.49963425
51Pustule (HP:0200039)2.49047271
52Medulloblastoma (HP:0002885)2.48046781
53Abnormality of the preputium (HP:0100587)2.47613151
54Keratoconjunctivitis sicca (HP:0001097)2.47097936
55Selective tooth agenesis (HP:0001592)2.47076859
56Recurrent sinusitis (HP:0011108)2.46936713
57Aplasia/Hypoplasia of the patella (HP:0006498)2.46914378
58Meckel diverticulum (HP:0002245)2.46176108
59Recurrent cutaneous fungal infections (HP:0011370)2.44582965
60Chronic mucocutaneous candidiasis (HP:0002728)2.44582965
61Encephalitis (HP:0002383)2.44122307
62Myelodysplasia (HP:0002863)2.43828546
63Autoimmune thrombocytopenia (HP:0001973)2.43161994
64Rhabdomyosarcoma (HP:0002859)2.42418487
65Papilloma (HP:0012740)2.41242295
66Verrucae (HP:0200043)2.41242295
67Recurrent abscess formation (HP:0002722)2.40092057
68Recurrent viral infections (HP:0004429)2.39807204
69Arterial thrombosis (HP:0004420)2.39416358
70Absent radius (HP:0003974)2.37942261
71Gangrene (HP:0100758)2.37544459
72Abnormality of pyrimidine metabolism (HP:0004353)2.35971187
73Elevated erythrocyte sedimentation rate (HP:0003565)2.35461406
74Spontaneous hematomas (HP:0007420)2.33565022
75Abnormality of the ileum (HP:0001549)2.31935044
76Amaurosis fugax (HP:0100576)2.31844893
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31455316
78Disinhibition (HP:0000734)2.31449631
79Rough bone trabeculation (HP:0100670)2.31162944
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.27334615
81Sepsis (HP:0100806)2.27068298
82Viral hepatitis (HP:0006562)2.24756005
83IgM deficiency (HP:0002850)2.24209922
84Bone marrow hypocellularity (HP:0005528)2.23844215
85Chronic diarrhea (HP:0002028)2.23753628
86Basal cell carcinoma (HP:0002671)2.22029640
87Epistaxis (HP:0000421)2.21777071
88Papillary thyroid carcinoma (HP:0002895)2.21310793
89Chest pain (HP:0100749)2.18141578
90Keratoconjunctivitis (HP:0001096)2.17552769
91Pulmonary infiltrates (HP:0002113)2.16729916
92Fatigue (HP:0012378)2.16322993
93Eosinophilia (HP:0001880)2.15999011
94Recurrent bacterial skin infections (HP:0005406)2.15954711
95Abnormality of T cell physiology (HP:0011840)2.15919813
96Aplasia involving forearm bones (HP:0009822)2.15805864
97Absent forearm bone (HP:0003953)2.15805864
98Vacuolated lymphocytes (HP:0001922)2.14217562
99Lymphopenia (HP:0001888)2.13178343
100Pallor (HP:0000980)2.12777398
101Recurrent fungal infections (HP:0002841)2.12136038
102Lymphoma (HP:0002665)2.11974985
103Gingivitis (HP:0000230)2.11584484
104Thrombocytosis (HP:0001894)2.10586769
105Leukocytosis (HP:0001974)2.10417949
106Eczematoid dermatitis (HP:0000976)2.08887051
107Dysostosis multiplex (HP:0000943)2.06984494
108Multiple enchondromatosis (HP:0005701)2.06376353
109Gingival bleeding (HP:0000225)2.05753865
110Increased cerebral lipofuscin (HP:0011813)2.05069298
111Hypochromic anemia (HP:0001931)2.04687978
112Abnormality of the prostate (HP:0008775)2.04516592
113Increased IgM level (HP:0003496)2.04316838
114Curly hair (HP:0002212)2.03747829
115Abnormality of cells of the lymphoid lineage (HP:0012140)2.00324425
116Nausea (HP:0002018)2.00227445
117Chronic sinusitis (HP:0011109)1.99654437
118Tracheoesophageal fistula (HP:0002575)1.98158247
119Hypoplasia of the thymus (HP:0000778)1.97766699
120Biliary tract neoplasm (HP:0100574)1.97718105
12111 pairs of ribs (HP:0000878)1.97630463
122Bronchitis (HP:0012387)1.97212387
123Neoplasm of the pancreas (HP:0002894)1.97011592
124Cellular immunodeficiency (HP:0005374)1.96972893
125Restrictive lung disease (HP:0002091)1.96681609
126Recurrent pneumonia (HP:0006532)1.96641148
127Small intestinal stenosis (HP:0012848)1.95829879
128Duodenal stenosis (HP:0100867)1.95829879
129Micronodular cirrhosis (HP:0001413)1.94320957
130Clubbing of toes (HP:0100760)1.94130397
131Hemoptysis (HP:0002105)1.93629079
132Skin ulcer (HP:0200042)1.93201464
133Abnormality of T cells (HP:0002843)1.93152005
134Leukopenia (HP:0001882)1.92559091
135Ectopic kidney (HP:0000086)1.91485647
136Prominent nose (HP:0000448)1.91466257
137Sparse eyelashes (HP:0000653)1.89579302
138Macrocytic anemia (HP:0001972)1.87281780
139Deep philtrum (HP:0002002)1.87073927
140Supernumerary spleens (HP:0009799)1.86961213
141Aplasia/hypoplasia of the humerus (HP:0006507)1.85560825
142IgG deficiency (HP:0004315)1.85487854
143Hypergammaglobulinemia (HP:0010702)1.84786603
144Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84571263
145IgA deficiency (HP:0002720)1.84476679
146Abnormal trabecular bone morphology (HP:0100671)1.84266228
147Aplasia/Hypoplasia of the thymus (HP:0010515)1.84042345
148Skin rash (HP:0000988)1.83629307
149Petechiae (HP:0000967)1.83178981
150Cleft eyelid (HP:0000625)1.83061975
151Aplastic anemia (HP:0001915)1.82147306
152Chronic otitis media (HP:0000389)1.81904393
153Abnormality of macrophages (HP:0004311)1.81715837
154Slow saccadic eye movements (HP:0000514)1.81077059
155Microretrognathia (HP:0000308)1.80447374
156Rectal fistula (HP:0100590)1.80190330
157Rectovaginal fistula (HP:0000143)1.80190330
158Abnormal spermatogenesis (HP:0008669)1.79539847
159Sloping forehead (HP:0000340)1.78215455
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.77753510
161Trismus (HP:0000211)1.76638843
162Prostate neoplasm (HP:0100787)1.75189841
163Mediastinal lymphadenopathy (HP:0100721)1.75048426
164Rib fusion (HP:0000902)1.74569613
165Granulocytopenia (HP:0001913)1.73259426
166Blepharitis (HP:0000498)1.72296127
167Neoplasm of the oral cavity (HP:0100649)1.71991562
168Premature ovarian failure (HP:0008209)1.71753409
169Abnormality of T cell number (HP:0011839)1.70049184
170Shawl scrotum (HP:0000049)1.69732675
171Stenosis of the external auditory canal (HP:0000402)1.69556783
172Squamous cell carcinoma (HP:0002860)1.69395234
173Poor head control (HP:0002421)1.68546239
174Combined immunodeficiency (HP:0005387)1.67839369
175Cellulitis (HP:0100658)1.67653836
176Metaphyseal cupping (HP:0003021)1.67456197
177Spinal muscular atrophy (HP:0007269)1.66761058
178Missing ribs (HP:0000921)1.66232221
179Intestinal fistula (HP:0100819)1.64554580
180Premature graying of hair (HP:0002216)1.63682195
181Cafe-au-lait spot (HP:0000957)1.63107998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.77297662
2RIPK43.58909270
3BUB13.25104548
4BMPR22.95507209
5NEK22.75987643
6CDC72.75770358
7EIF2AK12.73595056
8EPHA22.70972382
9CDK122.57064475
10PRPF4B2.56360490
11ERN12.22196498
12ACVR1B2.21566333
13BRSK22.20766643
14MAP3K132.08649548
15SRPK12.02676753
16TTK1.99230191
17STK101.97592217
18RPS6KB21.96526396
19NME21.96291640
20SIK31.93761026
21RPS6KA41.90001412
22DYRK31.84791225
23TRIB31.69608645
24STK241.67335000
25EIF2AK31.66513408
26PLK11.64026146
27MST41.59916925
28CDK71.59365196
29STK41.58486184
30PIM11.58109394
31NEK11.57526705
32MKNK11.53833774
33MKNK21.49442461
34TYK21.48511963
35CDK41.46033379
36JAK11.42988075
37ATR1.40997997
38AURKB1.38247144
39SCYL21.36673533
40PLK41.36451443
41MAP3K101.31862259
42MAP3K81.30036674
43SYK1.27752900
44EEF2K1.26158719
45MAP4K11.26065460
46IRAK11.23161038
47NEK61.22114938
48CHEK21.21832281
49IRAK21.21021065
50TAOK11.20749358
51TLK11.19679679
52TSSK61.17870316
53VRK11.16146986
54MAP3K21.15514290
55JAK21.13840926
56TESK21.13721213
57TAOK31.12069991
58TAOK21.11290825
59MAP3K11.10697049
60STK31.05909146
61FGR1.05300121
62ZAK1.04334980
63GRK61.02768297
64IRAK31.01971888
65PLK31.01699491
66IRAK41.00042384
67IKBKB0.98719118
68FLT30.98041685
69HCK0.97349830
70JAK30.97341414
71AKT30.96255820
72CDK60.95970051
73MAPKAPK30.94922267
74SIK10.94551897
75FGFR30.94038167
76CHEK10.93771325
77PASK0.93485623
78PAK40.91309119
79LRRK20.90119100
80TXK0.89302129
81PIM20.85806978
82KSR20.84762407
83MAP2K30.84351400
84CHUK0.82675126
85TNK20.82154267
86BRSK10.81197142
87MAP3K140.80821617
88MARK30.80545273
89PIK3CG0.79287502
90PBK0.78587979
91LCK0.77203588
92ITK0.77131379
93AURKA0.75474447
94EIF2AK20.75249864
95ALK0.74601279
96STK160.74310799
97ATM0.72877440
98FES0.72197359
99KIT0.69242958
100PDK10.68629077
101MAP3K50.68073776
102BTK0.67947385
103FGFR40.67734380
104CDK20.66995045
105NEK90.66458367
106IKBKE0.66034654
107TBK10.64457127
108MAP3K30.63949967
109PKN20.63612625
110ARAF0.62598564
111RPS6KA50.59860038
112ZAP700.59681048
113MATK0.59125625
114RAF10.57194079
115BRD40.57004094
116PDPK10.56301234
117TGFBR10.54078431
118RPS6KB10.53781504
119CSK0.51455529
120CDK90.51247809
121CSNK2A10.50978557
122TEC0.50778357
123HIPK20.49765393
124MAPK110.49356485
125CSNK2A20.49252395
126CSF1R0.48509918
127STK38L0.47636712
128GRK10.46122008
129BLK0.45770499
130RET0.45561355
131DYRK1B0.44189462
132TGFBR20.44089307
133KDR0.43308684
134MAP2K20.43215419
135PRKCI0.42330075
136PAK10.40364811
137SMG10.40145560
138MAPKAPK20.40119169
139MAP3K120.39310999
140RPS6KL10.38947268
141RPS6KC10.38947268
142YES10.38631171
143MELK0.38206477
144PRKCQ0.38094462
145BCKDK0.37697688
146BRAF0.37619631
147ABL10.36135111
148NLK0.35727890
149CDK10.35712795
150PIK3CA0.35578076
151LYN0.33238342

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96308764
2Mismatch repair_Homo sapiens_hsa034303.51540855
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37324739
4RNA transport_Homo sapiens_hsa030132.65589325
5Homologous recombination_Homo sapiens_hsa034402.51713113
6Spliceosome_Homo sapiens_hsa030402.50566007
7RNA polymerase_Homo sapiens_hsa030202.49743135
8Base excision repair_Homo sapiens_hsa034102.46861118
9Ribosome_Homo sapiens_hsa030102.43372833
10Autoimmune thyroid disease_Homo sapiens_hsa053202.38949171
11One carbon pool by folate_Homo sapiens_hsa006702.36169025
12Cell cycle_Homo sapiens_hsa041102.33354735
13Proteasome_Homo sapiens_hsa030502.25661635
14Nucleotide excision repair_Homo sapiens_hsa034202.23493545
15Type I diabetes mellitus_Homo sapiens_hsa049402.08501556
16Pyrimidine metabolism_Homo sapiens_hsa002401.98549269
17Fanconi anemia pathway_Homo sapiens_hsa034601.86065271
18p53 signaling pathway_Homo sapiens_hsa041151.81846476
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79938303
20Non-homologous end-joining_Homo sapiens_hsa034501.74928092
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73024688
22Basal transcription factors_Homo sapiens_hsa030221.63460296
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55588616
24Herpes simplex infection_Homo sapiens_hsa051681.52082100
25RNA degradation_Homo sapiens_hsa030181.49933374
26Rheumatoid arthritis_Homo sapiens_hsa053231.47410013
27T cell receptor signaling pathway_Homo sapiens_hsa046601.47400758
28Antigen processing and presentation_Homo sapiens_hsa046121.42507439
29Systemic lupus erythematosus_Homo sapiens_hsa053221.32176103
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29222283
31Non-small cell lung cancer_Homo sapiens_hsa052231.28979963
32mRNA surveillance pathway_Homo sapiens_hsa030151.28789093
33Folate biosynthesis_Homo sapiens_hsa007901.27850254
34Malaria_Homo sapiens_hsa051441.24138606
35Pentose phosphate pathway_Homo sapiens_hsa000301.21841031
36Epstein-Barr virus infection_Homo sapiens_hsa051691.20527767
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.17776356
38Legionellosis_Homo sapiens_hsa051341.17080593
39Pancreatic cancer_Homo sapiens_hsa052121.15877591
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15869836
41Selenocompound metabolism_Homo sapiens_hsa004501.13623744
42Chemokine signaling pathway_Homo sapiens_hsa040621.09515670
43Viral carcinogenesis_Homo sapiens_hsa052031.08992442
44Renal cell carcinoma_Homo sapiens_hsa052111.07462473
45Primary immunodeficiency_Homo sapiens_hsa053401.07269603
46Lysosome_Homo sapiens_hsa041421.05255647
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02754640
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00786367
49Measles_Homo sapiens_hsa051621.00242180
50Prolactin signaling pathway_Homo sapiens_hsa049170.96971635
51Phagosome_Homo sapiens_hsa041450.96942821
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.95541086
53Purine metabolism_Homo sapiens_hsa002300.93521543
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.92974527
55Leishmaniasis_Homo sapiens_hsa051400.92091947
56Influenza A_Homo sapiens_hsa051640.91528757
57Vitamin B6 metabolism_Homo sapiens_hsa007500.90592623
58Endometrial cancer_Homo sapiens_hsa052130.89365976
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88486387
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83819601
61Apoptosis_Homo sapiens_hsa042100.83634222
62Prostate cancer_Homo sapiens_hsa052150.82169801
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.82087722
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.81804990
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81742811
66Salmonella infection_Homo sapiens_hsa051320.81361343
67mTOR signaling pathway_Homo sapiens_hsa041500.80985866
68Platelet activation_Homo sapiens_hsa046110.80723835
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80565549
70African trypanosomiasis_Homo sapiens_hsa051430.80301552
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80024720
72FoxO signaling pathway_Homo sapiens_hsa040680.77742037
73VEGF signaling pathway_Homo sapiens_hsa043700.76076424
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74880490
75Bladder cancer_Homo sapiens_hsa052190.74329701
76Thyroid cancer_Homo sapiens_hsa052160.73604207
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71623644
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.71082407
79HTLV-I infection_Homo sapiens_hsa051660.70273081
80Small cell lung cancer_Homo sapiens_hsa052220.69759479
81Biosynthesis of amino acids_Homo sapiens_hsa012300.69282692
82Insulin resistance_Homo sapiens_hsa049310.66928649
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.66197633
84Allograft rejection_Homo sapiens_hsa053300.66167786
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66048022
86Hematopoietic cell lineage_Homo sapiens_hsa046400.64782416
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63659439
88Hepatitis B_Homo sapiens_hsa051610.62085095
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61652498
90B cell receptor signaling pathway_Homo sapiens_hsa046620.61352721
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60692685
92Shigellosis_Homo sapiens_hsa051310.60581346
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60152279
94MicroRNAs in cancer_Homo sapiens_hsa052060.58635351
95Inositol phosphate metabolism_Homo sapiens_hsa005620.57141024
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56173060
97Glutathione metabolism_Homo sapiens_hsa004800.55864964
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.55520415
99Other glycan degradation_Homo sapiens_hsa005110.54609793
100Dorso-ventral axis formation_Homo sapiens_hsa043200.53201221
101Staphylococcus aureus infection_Homo sapiens_hsa051500.52939129
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.52574974
103Sulfur relay system_Homo sapiens_hsa041220.51860407
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51828578
105Acute myeloid leukemia_Homo sapiens_hsa052210.51480667
106Sphingolipid metabolism_Homo sapiens_hsa006000.50663726
107Graft-versus-host disease_Homo sapiens_hsa053320.50508621
108ErbB signaling pathway_Homo sapiens_hsa040120.50058027
109Choline metabolism in cancer_Homo sapiens_hsa052310.49849243
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49330436
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48299486
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47772520
113Endocytosis_Homo sapiens_hsa041440.47711802
114Renin-angiotensin system_Homo sapiens_hsa046140.46299129
115Toxoplasmosis_Homo sapiens_hsa051450.46272489
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46190388
117Colorectal cancer_Homo sapiens_hsa052100.43713116
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.43087855
119Chronic myeloid leukemia_Homo sapiens_hsa052200.41859437
120Osteoclast differentiation_Homo sapiens_hsa043800.40967389
121Amoebiasis_Homo sapiens_hsa051460.40938459
122Tuberculosis_Homo sapiens_hsa051520.40609299
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40366469
124Notch signaling pathway_Homo sapiens_hsa043300.39265425
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38553276
126Carbon metabolism_Homo sapiens_hsa012000.38540807
127TNF signaling pathway_Homo sapiens_hsa046680.38222747
128Galactose metabolism_Homo sapiens_hsa000520.36345421
129Hepatitis C_Homo sapiens_hsa051600.35805077
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35549184
131Insulin signaling pathway_Homo sapiens_hsa049100.34968144
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34694298
133Vitamin digestion and absorption_Homo sapiens_hsa049770.34636073
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32877361
135Pertussis_Homo sapiens_hsa051330.32783566
136Oocyte meiosis_Homo sapiens_hsa041140.31967132
137Regulation of autophagy_Homo sapiens_hsa041400.31394870
138Viral myocarditis_Homo sapiens_hsa054160.30990018
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30950237
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30634460
141TGF-beta signaling pathway_Homo sapiens_hsa043500.29927162
142Adherens junction_Homo sapiens_hsa045200.29896199
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.29306405
144Asthma_Homo sapiens_hsa053100.29261039
145HIF-1 signaling pathway_Homo sapiens_hsa040660.27927025
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27541462
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.27469153
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27135399
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24884281

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