PLEKHG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.68098561
2axon ensheathment in central nervous system (GO:0032291)7.68098561
3axon ensheathment (GO:0008366)5.24865150
4ensheathment of neurons (GO:0007272)5.24865150
5myelination (GO:0042552)5.23279589
6radial glial cell differentiation (GO:0060019)4.63217045
7fatty acid elongation (GO:0030497)4.60132919
8peptidyl-tyrosine autophosphorylation (GO:0038083)4.52245613
9Notch signaling involved in heart development (GO:0061314)4.38027916
10tongue development (GO:0043586)4.34088388
11presynaptic membrane assembly (GO:0097105)4.09824254
12asymmetric protein localization (GO:0008105)4.04160737
13neuronal stem cell maintenance (GO:0097150)3.98316932
14peripheral nervous system axon ensheathment (GO:0032292)3.94986096
15myelination in peripheral nervous system (GO:0022011)3.94986096
16negative regulation of neurotransmitter secretion (GO:0046929)3.89921431
17apical protein localization (GO:0045176)3.86905904
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86422918
19blood vessel maturation (GO:0001955)3.84293417
20myelin maintenance (GO:0043217)3.73441655
21long-chain fatty acid biosynthetic process (GO:0042759)3.72747406
22glomerular basement membrane development (GO:0032836)3.68342920
23presynaptic membrane organization (GO:0097090)3.65309918
24protein localization to endosome (GO:0036010)3.63252906
25calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.62619305
26heart valve formation (GO:0003188)3.59409517
27negative regulation of neurotransmitter transport (GO:0051589)3.57319046
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.52457560
29axon extension involved in axon guidance (GO:0048846)3.52457560
30negative regulation of protein localization to cell surface (GO:2000009)3.48920011
31adhesion of symbiont to host cell (GO:0044650)3.47468635
32virion attachment to host cell (GO:0019062)3.47468635
33L-amino acid import (GO:0043092)3.42677256
34postsynaptic membrane organization (GO:0001941)3.36604968
35glomerular filtration (GO:0003094)3.36296758
36glomerular visceral epithelial cell development (GO:0072015)3.33507303
37retinal ganglion cell axon guidance (GO:0031290)3.32785069
38nonmotile primary cilium assembly (GO:0035058)3.30184255
39appendage development (GO:0048736)3.28108009
40limb development (GO:0060173)3.28108009
41neuron remodeling (GO:0016322)3.28067841
42epithelial cilium movement (GO:0003351)3.26172692
43cilium or flagellum-dependent cell motility (GO:0001539)3.25361684
44pyrimidine nucleobase catabolic process (GO:0006208)3.22763619
45glycerophospholipid catabolic process (GO:0046475)3.19335126
46cilium movement (GO:0003341)3.19209299
47ventricular trabecula myocardium morphogenesis (GO:0003222)3.17751842
48renal filtration (GO:0097205)3.16102550
49astrocyte development (GO:0014002)3.15432751
50membrane tubulation (GO:0097320)3.14942095
51generation of neurons (GO:0048699)3.13804777
52establishment of nucleus localization (GO:0040023)3.11474206
53eye photoreceptor cell differentiation (GO:0001754)3.10697992
54photoreceptor cell differentiation (GO:0046530)3.10697992
55glomerular epithelial cell development (GO:0072310)3.07011902
56neuron fate determination (GO:0048664)3.06095093
57intraciliary transport (GO:0042073)3.02075642
58artery development (GO:0060840)3.00535010
59heart trabecula morphogenesis (GO:0061384)2.98336535
60regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.97203357
61negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.96444210
62nucleus localization (GO:0051647)2.95616438
63interleukin-6-mediated signaling pathway (GO:0070102)2.95188338
64oocyte development (GO:0048599)2.88588325
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.87440206
66response to lipoprotein particle (GO:0055094)2.87103897
67amino acid import (GO:0043090)2.86403510
68interkinetic nuclear migration (GO:0022027)2.85741288
69regulation of pigment cell differentiation (GO:0050932)2.85257015
70establishment of planar polarity (GO:0001736)2.84251679
71establishment of tissue polarity (GO:0007164)2.84251679
72adhesion of symbiont to host (GO:0044406)2.81838108
73semaphorin-plexin signaling pathway (GO:0071526)2.80638806
74endothelial cell differentiation (GO:0045446)2.78362848
75regulation of collateral sprouting (GO:0048670)2.76300996
76fibroblast migration (GO:0010761)2.70392442
77platelet-derived growth factor receptor signaling pathway (GO:0048008)2.68716897
78lymph vessel development (GO:0001945)2.68637492
79positive regulation of developmental pigmentation (GO:0048087)2.68595325
80genitalia morphogenesis (GO:0035112)2.66350006
81oligodendrocyte differentiation (GO:0048709)2.63442142
82negative regulation of axon extension involved in axon guidance (GO:0048843)2.61715937
83cell surface receptor signaling pathway involved in heart development (GO:0061311)2.60884000
84negative regulation of axon guidance (GO:1902668)2.60453775
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.60133422
86enteric nervous system development (GO:0048484)2.60112776
87positive regulation of neurological system process (GO:0031646)2.59849720
88cholesterol biosynthetic process (GO:0006695)2.59068108
89cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.58614520
90epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.58539143
91cilium morphogenesis (GO:0060271)2.58503185
92mesenchyme morphogenesis (GO:0072132)2.57557564
93lateral sprouting from an epithelium (GO:0060601)2.57103667
94centriole replication (GO:0007099)2.56443255
95ephrin receptor signaling pathway (GO:0048013)2.56376796
96regulation of memory T cell differentiation (GO:0043380)2.55474973
97mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.55078070
98positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.55078070
99regulation of chemokine-mediated signaling pathway (GO:0070099)2.54772225
100regulation of axon guidance (GO:1902667)2.52400363
101regulation of axon extension involved in axon guidance (GO:0048841)2.52083872
102retinal cone cell development (GO:0046549)2.51467944
103retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50831608
104central nervous system projection neuron axonogenesis (GO:0021952)2.50730237
105amyloid precursor protein metabolic process (GO:0042982)2.50470980
106glomerulus development (GO:0032835)2.49339198
107negative regulation of axonogenesis (GO:0050771)2.48961911
108regulation of female gonad development (GO:2000194)2.48457126
109cerebral cortex development (GO:0021987)2.48159845
110creatine metabolic process (GO:0006600)2.48098668
111dentate gyrus development (GO:0021542)2.47659834
112nerve growth factor signaling pathway (GO:0038180)2.47155963
113response to methylmercury (GO:0051597)2.46722906
114endothelium development (GO:0003158)2.45959153
115negative regulation of axon extension (GO:0030517)2.45497520
116smoothened signaling pathway (GO:0007224)2.45199783
117regulation of somitogenesis (GO:0014807)2.43916436
118positive regulation of male gonad development (GO:2000020)2.43126370
119regulation of acrosome reaction (GO:0060046)2.42882659
120response to redox state (GO:0051775)2.41609733
121import into cell (GO:0098657)2.41476267
122vocalization behavior (GO:0071625)2.41341071
123negative regulation of Rho protein signal transduction (GO:0035024)2.41124414
124olfactory bulb development (GO:0021772)2.38710592
125nucleobase catabolic process (GO:0046113)2.38684306
126auditory behavior (GO:0031223)2.38272762
127negative regulation of astrocyte differentiation (GO:0048712)2.37145506
128morphogenesis of an epithelial sheet (GO:0002011)2.36700224
129long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.36316201
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.35804990
131lens fiber cell development (GO:0070307)2.35543019
132forebrain neuron differentiation (GO:0021879)2.34897664
133positive regulation of glial cell differentiation (GO:0045687)2.34895501
134positive regulation of neural precursor cell proliferation (GO:2000179)2.34767831
135negative regulation of vascular permeability (GO:0043116)2.34229027
136camera-type eye morphogenesis (GO:0048593)2.34220039
137V(D)J recombination (GO:0033151)2.33673675
138hindlimb morphogenesis (GO:0035137)2.33576053
139cellular response to hepatocyte growth factor stimulus (GO:0035729)2.33054794
140response to hepatocyte growth factor (GO:0035728)2.33054794
141mechanosensory behavior (GO:0007638)2.32239682
142cell proliferation in forebrain (GO:0021846)2.32223622
143establishment of spindle orientation (GO:0051294)2.31833936
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31591933
145cilium assembly (GO:0042384)2.31568030
146cytoplasmic mRNA processing body assembly (GO:0033962)2.30257984
147endocardial cushion morphogenesis (GO:0003203)2.30224925
148cilium organization (GO:0044782)2.29557709
149somite development (GO:0061053)2.28702421
150regulation of p38MAPK cascade (GO:1900744)2.28199727
151photoreceptor cell maintenance (GO:0045494)2.28027800
152sterol biosynthetic process (GO:0016126)2.27730944
153negative regulation of inclusion body assembly (GO:0090084)2.26606563
154cell migration involved in sprouting angiogenesis (GO:0002042)2.26114743
155positive regulation of p38MAPK cascade (GO:1900745)2.25797522
156Rap protein signal transduction (GO:0032486)2.25226599
157long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.24310028
158establishment of mitochondrion localization (GO:0051654)2.22612769
159positive regulation of gliogenesis (GO:0014015)2.22504733
160lymphangiogenesis (GO:0001946)2.21019606
161branching involved in salivary gland morphogenesis (GO:0060445)2.18135520
162positive regulation of interleukin-17 production (GO:0032740)2.18085344
163cerebral cortex radially oriented cell migration (GO:0021799)2.17244892
164substantia nigra development (GO:0021762)2.16382758
165potassium ion import (GO:0010107)2.16338628
166neuron recognition (GO:0008038)2.14996299
167isoprenoid biosynthetic process (GO:0008299)2.12016255
168dendrite morphogenesis (GO:0048813)2.10417380
169axonal fasciculation (GO:0007413)2.10180465
170labyrinthine layer development (GO:0060711)2.09022378
171limb bud formation (GO:0060174)2.08668303
172leukocyte migration involved in inflammatory response (GO:0002523)2.07466241
173positive regulation of protein kinase C signaling (GO:0090037)2.06452661
174transmission of nerve impulse (GO:0019226)2.06269982
175organ growth (GO:0035265)2.04469263
176mesenchymal cell proliferation (GO:0010463)2.03915215
177neuron cell-cell adhesion (GO:0007158)2.03629022
178vascular endothelial growth factor signaling pathway (GO:0038084)2.03546608
179ear development (GO:0043583)2.02460909
180regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.01947373
181coronary vasculature morphogenesis (GO:0060977)2.01686910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73335917
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61638932
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12161299
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.04640879
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00817272
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96335762
7GBX2_23144817_ChIP-Seq_PC3_Human1.93794492
8BP1_19119308_ChIP-ChIP_Hs578T_Human1.88779587
9EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87102031
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87102031
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86969754
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85723981
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82893346
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82615102
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82382638
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82283936
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.79140507
18* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77427477
19EZH2_22144423_ChIP-Seq_EOC_Human1.76047641
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73970746
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73786040
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.72347437
23IGF1R_20145208_ChIP-Seq_DFB_Human1.72330026
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70653941
25AR_21572438_ChIP-Seq_LNCaP_Human1.67297475
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.67218757
27FUS_26573619_Chip-Seq_HEK293_Human1.66308860
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66264455
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.64580738
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.64535489
31DROSHA_22980978_ChIP-Seq_HELA_Human1.63987801
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62520227
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.61914064
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59574408
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.59359973
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57103636
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56660959
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55270678
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55270678
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54076321
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53938843
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50139241
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50035378
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.49031980
45TP53_16413492_ChIP-PET_HCT116_Human1.47922106
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47665465
47* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46831186
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46057159
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.44788558
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44784562
51ZNF274_21170338_ChIP-Seq_K562_Hela1.44130125
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42805960
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.42457332
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42313836
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41820011
56EWS_26573619_Chip-Seq_HEK293_Human1.41482696
57AHR_22903824_ChIP-Seq_MCF-7_Human1.39982047
58* TCF4_23295773_ChIP-Seq_U87_Human1.38368974
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37790246
60* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36864523
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36862919
62AR_25329375_ChIP-Seq_VCAP_Human1.36274441
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35351789
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35063428
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.34829693
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33230173
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32805015
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.30449628
69RUNX2_22187159_ChIP-Seq_PCA_Human1.30330560
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29460434
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.29015656
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27023726
73BCAT_22108803_ChIP-Seq_LS180_Human1.26934532
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.26565123
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.26547530
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26471366
77CBP_20019798_ChIP-Seq_JUKART_Human1.26471366
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25359727
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24330202
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24330202
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24330202
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24105306
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.23523502
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23156666
85KDM2B_26808549_Chip-Seq_REH_Human1.23012366
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.22374052
87RNF2_27304074_Chip-Seq_NSC_Mouse1.21915191
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20927923
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20903076
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20903076
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20664438
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.18362394
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17231904
94RXR_22108803_ChIP-Seq_LS180_Human1.16617522
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16220201
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13582985
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12591454
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.11944179
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.11862331
100VDR_22108803_ChIP-Seq_LS180_Human1.11688063
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.11258846
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11197038
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10047646
104AR_19668381_ChIP-Seq_PC3_Human1.09709369
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08965831
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.08450909
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08075624
108CJUN_26792858_Chip-Seq_BT549_Human1.06868949
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06780355
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06505642
111STAT3_23295773_ChIP-Seq_U87_Human1.06186923
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06042737
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.05795849
114SMAD4_21799915_ChIP-Seq_A2780_Human1.04846447
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.04732031
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04561317
117TAF15_26573619_Chip-Seq_HEK293_Human1.04521637
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.04291546
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03953481
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03747664
121ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02655137
122KDM2B_26808549_Chip-Seq_K562_Human1.02516175
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.01274067
124VDR_24787735_ChIP-Seq_THP-1_Human1.00255936
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99516279
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.98783161
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98567864
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97962376
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97474780
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96710203
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96598861
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.96538318
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96517661
134TP53_18474530_ChIP-ChIP_U2OS_Human0.96155792
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94322651
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93126927
137P300_19829295_ChIP-Seq_ESCs_Human0.92484504
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90923243
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90910961
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90792631
141* TP63_23658742_ChIP-Seq_EP156T_Human0.90769270
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.90530954
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90293246
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88567819
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88377665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.92688957
2MP0004272_abnormal_basement_membrane3.36106819
3MP0004885_abnormal_endolymph3.13860507
4MP0003690_abnormal_glial_cell2.94617719
5MP0006292_abnormal_olfactory_placode2.83435610
6MP0005623_abnormal_meninges_morphology2.78925751
7MP0001346_abnormal_lacrimal_gland2.72975642
8MP0003950_abnormal_plasma_membrane2.71710329
9MP0008789_abnormal_olfactory_epithelium2.69756043
10MP0010678_abnormal_skin_adnexa2.59493102
11MP0000383_abnormal_hair_follicle2.37731906
12MP0003880_abnormal_central_pattern2.32076331
13MP0010368_abnormal_lymphatic_system2.30896995
14MP0000569_abnormal_digit_pigmentation2.26924213
15MP0001293_anophthalmia2.25498052
16MP0005499_abnormal_olfactory_system2.24960251
17MP0005394_taste/olfaction_phenotype2.24960251
18MP0000778_abnormal_nervous_system2.18140141
19MP0004742_abnormal_vestibular_system2.12286972
20MP0004270_analgesia2.11023591
21MP0000579_abnormal_nail_morphology2.09882877
22MP0003329_amyloid_beta_deposits2.07868116
23MP0001485_abnormal_pinna_reflex2.03246212
24MP0005167_abnormal_blood-brain_barrier2.01233217
25MP0005171_absent_coat_pigmentation2.00695406
26MP0002138_abnormal_hepatobiliary_system1.95268873
27MP0001851_eye_inflammation1.88249231
28MP0003634_abnormal_glial_cell1.87668104
29MP0002233_abnormal_nose_morphology1.86513500
30MP0001879_abnormal_lymphatic_vessel1.84205235
31MP0002638_abnormal_pupillary_reflex1.82583042
32MP0002653_abnormal_ependyma_morphology1.78847988
33MP0000462_abnormal_digestive_system1.77698295
34MP0004859_abnormal_synaptic_plasticity1.75029657
35MP0001486_abnormal_startle_reflex1.72284245
36MP0003632_abnormal_nervous_system1.66949796
37MP0000049_abnormal_middle_ear1.63690548
38MP0002254_reproductive_system_inflammat1.62710481
39MP0002092_abnormal_eye_morphology1.56875841
40MP0000537_abnormal_urethra_morphology1.54385792
41MP0001286_abnormal_eye_development1.53157446
42MP0005187_abnormal_penis_morphology1.52817129
43MP0005503_abnormal_tendon_morphology1.50765900
44MP0004134_abnormal_chest_morphology1.47742340
45MP0009053_abnormal_anal_canal1.44144194
46MP0001984_abnormal_olfaction1.43373959
47MP0005409_darkened_coat_color1.42883777
48MP0004185_abnormal_adipocyte_glucose1.42007060
49MP0000566_synostosis1.40776189
50MP0000647_abnormal_sebaceous_gland1.40015399
51MP0001661_extended_life_span1.39967420
52MP0000631_abnormal_neuroendocrine_gland1.39590067
53MP0002234_abnormal_pharynx_morphology1.39140893
54MP0003121_genomic_imprinting1.37769823
55MP0003937_abnormal_limbs/digits/tail_de1.36224163
56MP0004133_heterotaxia1.36214777
57MP0005275_abnormal_skin_tensile1.34204788
58MP0001299_abnormal_eye_distance/1.33800998
59MP0003136_yellow_coat_color1.30293715
60MP0005391_vision/eye_phenotype1.29922804
61MP0002009_preneoplasia1.29198507
62MP0004084_abnormal_cardiac_muscle1.25623112
63MP0002127_abnormal_cardiovascular_syste1.25550072
64MP0002272_abnormal_nervous_system1.25382091
65MP0001502_abnormal_circadian_rhythm1.25258718
66MP0003453_abnormal_keratinocyte_physiol1.22964098
67MP0000428_abnormal_craniofacial_morphol1.22898107
68MP0002064_seizures1.22808168
69MP0000733_abnormal_muscle_development1.21361099
70MP0000955_abnormal_spinal_cord1.19932855
71MP0000534_abnormal_ureter_morphology1.19519294
72MP0003045_fibrosis1.19085909
73MP0003385_abnormal_body_wall1.16931504
74MP0004036_abnormal_muscle_relaxation1.16441069
75MP0003631_nervous_system_phenotype1.15272544
76MP0001849_ear_inflammation1.13259704
77MP0000762_abnormal_tongue_morphology1.13065093
78MP0009250_abnormal_appendicular_skeleto1.12648869
79MP0003091_abnormal_cell_migration1.11725535
80MP0005253_abnormal_eye_physiology1.10589070
81MP0002282_abnormal_trachea_morphology1.09983491
82MP0002295_abnormal_pulmonary_circulatio1.08579531
83MP0002938_white_spotting1.05400893
84MP0006138_congestive_heart_failure1.05076775
85MP0002116_abnormal_craniofacial_bone1.03618037
86MP0006276_abnormal_autonomic_nervous1.03049265
87MP0000604_amyloidosis1.02656868
88MP0000467_abnormal_esophagus_morphology1.02181028
89MP0003119_abnormal_digestive_system1.02138279
90MP0006072_abnormal_retinal_apoptosis1.02099413
91MP0008057_abnormal_DNA_replication1.00232537
92MP0003635_abnormal_synaptic_transmissio1.00039104
93MP0004858_abnormal_nervous_system0.99189988
94MP0002229_neurodegeneration0.98687065
95MP0003633_abnormal_nervous_system0.98552810
96MP0001963_abnormal_hearing_physiology0.98165012
97MP0003890_abnormal_embryonic-extraembry0.97820134
98MP0002882_abnormal_neuron_morphology0.97639279
99MP0002098_abnormal_vibrissa_morphology0.96580374
100MP0008877_abnormal_DNA_methylation0.95309781
101MP0002932_abnormal_joint_morphology0.94767771
102MP0003718_maternal_effect0.92612342
103MP0000767_abnormal_smooth_muscle0.92260750
104MP0001905_abnormal_dopamine_level0.91472235
105MP0003787_abnormal_imprinting0.90894115
106MP0003755_abnormal_palate_morphology0.90431931
107MP0000003_abnormal_adipose_tissue0.90377485
108MP0001348_abnormal_lacrimal_gland0.89251790
109MP0001177_atelectasis0.88877199
110MP0003942_abnormal_urinary_system0.88131644
111MP0005451_abnormal_body_composition0.88035803
112MP0000432_abnormal_head_morphology0.87533662
113MP0009046_muscle_twitch0.87489148
114MP0005423_abnormal_somatic_nervous0.86146348
115MP0002249_abnormal_larynx_morphology0.84530417
116MP0003938_abnormal_ear_development0.83247290
117MP0002109_abnormal_limb_morphology0.81961001
118MP0002752_abnormal_somatic_nervous0.81252680
119MP0005195_abnormal_posterior_eye0.81013990
120MP0001324_abnormal_eye_pigmentation0.80317697
121MP0002796_impaired_skin_barrier0.80187955
122MP0000026_abnormal_inner_ear0.79697520
123MP0002928_abnormal_bile_duct0.79458315
124MP0000465_gastrointestinal_hemorrhage0.79027781
125MP0000427_abnormal_hair_cycle0.78206743
126MP0004484_altered_response_of0.77620792
127MP0000377_abnormal_hair_follicle0.77497631
128MP0003878_abnormal_ear_physiology0.76900219
129MP0005377_hearing/vestibular/ear_phenot0.76900219
130MP0009780_abnormal_chondrocyte_physiolo0.76729953
131MP0004510_myositis0.76051577
132MP0002697_abnormal_eye_size0.75987963
133MP0002108_abnormal_muscle_morphology0.75669560
134MP0002925_abnormal_cardiovascular_devel0.75444904
135MP0001340_abnormal_eyelid_morphology0.75025901
136MP0001501_abnormal_sleep_pattern0.73892136
137MP0005508_abnormal_skeleton_morphology0.73823501
138MP0000613_abnormal_salivary_gland0.72006452
139MP0009384_cardiac_valve_regurgitation0.71876647
140MP0002063_abnormal_learning/memory/cond0.71852909
141MP0005248_abnormal_Harderian_gland0.71755318
142MP0010030_abnormal_orbit_morphology0.70660675
143MP0001614_abnormal_blood_vessel0.69910683
144MP0003935_abnormal_craniofacial_develop0.69795074
145MP0002152_abnormal_brain_morphology0.69406034
146MP0003861_abnormal_nervous_system0.69356165
147MP0003122_maternal_imprinting0.69241012
148MP0009745_abnormal_behavioral_response0.69234365
149MP0003075_altered_response_to0.69233892
150MP0004145_abnormal_muscle_electrophysio0.68897285

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.44458144
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.88314735
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.88314735
4Cerebral inclusion bodies (HP:0100314)3.99051216
5Abnormality of the corticospinal tract (HP:0002492)3.88729802
6True hermaphroditism (HP:0010459)3.64316972
7Peripheral hypomyelination (HP:0007182)3.55450804
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.48230917
9Short 4th metacarpal (HP:0010044)3.48230917
10Parakeratosis (HP:0001036)3.46955629
11Onion bulb formation (HP:0003383)3.36460511
12Chronic hepatic failure (HP:0100626)3.26845635
13Supranuclear gaze palsy (HP:0000605)3.19407748
14Alacrima (HP:0000522)3.01878053
15Thickened helices (HP:0000391)2.94264403
16Intention tremor (HP:0002080)2.91824649
17Sensory axonal neuropathy (HP:0003390)2.90867969
18Abnormality of the 4th metacarpal (HP:0010012)2.89704957
19Aplasia involving bones of the upper limbs (HP:0009823)2.86855109
20Aplasia of the phalanges of the hand (HP:0009802)2.86855109
21Aplasia involving bones of the extremities (HP:0009825)2.86855109
22Vitreoretinal degeneration (HP:0000655)2.86605205
23Focal segmental glomerulosclerosis (HP:0000097)2.82075236
24Segmental peripheral demyelination/remyelination (HP:0003481)2.81362450
25Pancreatic fibrosis (HP:0100732)2.79946684
26Coronal craniosynostosis (HP:0004440)2.77872887
27Esophageal atresia (HP:0002032)2.76205215
28Septo-optic dysplasia (HP:0100842)2.70360949
29Cutaneous finger syndactyly (HP:0010554)2.64473756
30Insidious onset (HP:0003587)2.64261798
31Termporal pattern (HP:0011008)2.64261798
32Hypoplasia of the iris (HP:0007676)2.63412977
33Pancreatic cysts (HP:0001737)2.62547327
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.59538270
35Abnormal auditory evoked potentials (HP:0006958)2.56991918
36Facial hemangioma (HP:0000329)2.52616779
37High anterior hairline (HP:0009890)2.49173413
38Spastic gait (HP:0002064)2.48447785
39Abnormality of the lower motor neuron (HP:0002366)2.48428246
40Arterial tortuosity (HP:0005116)2.47509162
41Tubulointerstitial nephritis (HP:0001970)2.47360757
42Postaxial foot polydactyly (HP:0001830)2.47351460
43Cerebral hemorrhage (HP:0001342)2.45138261
44Clumsiness (HP:0002312)2.44341160
45Nephronophthisis (HP:0000090)2.39863219
46Oligodactyly (HP:0012165)2.36648495
47Molar tooth sign on MRI (HP:0002419)2.35974215
48Abnormality of midbrain morphology (HP:0002418)2.35974215
49Oligodactyly (hands) (HP:0001180)2.34803981
50Gait imbalance (HP:0002141)2.33604016
51Abnormality of the renal medulla (HP:0100957)2.32993368
52Medial flaring of the eyebrow (HP:0010747)2.32691805
53Cutaneous syndactyly (HP:0012725)2.32486539
54Dysmetria (HP:0001310)2.30439163
55Persistence of primary teeth (HP:0006335)2.29845272
56Congenital primary aphakia (HP:0007707)2.29348779
57Neonatal short-limb short stature (HP:0008921)2.25588369
58Abnormality of the middle phalanges of the toes (HP:0010183)2.24995886
59Decreased lacrimation (HP:0000633)2.24489845
60Congenital hepatic fibrosis (HP:0002612)2.23228064
61Occipital encephalocele (HP:0002085)2.22081141
62Bile duct proliferation (HP:0001408)2.22068964
63Abnormal biliary tract physiology (HP:0012439)2.22068964
64Slow saccadic eye movements (HP:0000514)2.20436912
65Premature skin wrinkling (HP:0100678)2.19522167
66Relative macrocephaly (HP:0004482)2.19328776
67Anteriorly placed anus (HP:0001545)2.18582152
68Postaxial hand polydactyly (HP:0001162)2.17049142
69Genital tract atresia (HP:0001827)2.16687961
70Glomerulosclerosis (HP:0000096)2.15797382
71Hyporeflexia of lower limbs (HP:0002600)2.15095013
72Absent septum pellucidum (HP:0001331)2.14129476
73Cystic liver disease (HP:0006706)2.13837120
74Vascular tortuosity (HP:0004948)2.13254734
75Megalencephaly (HP:0001355)2.12269746
76Adactyly (HP:0009776)2.10493221
77Ankle clonus (HP:0011448)2.08947546
78Chin dimple (HP:0010751)2.08589054
79Papillary thyroid carcinoma (HP:0002895)2.08320920
80Abnormality of the ischium (HP:0003174)2.07102548
81Hypoplastic ischia (HP:0003175)2.07060115
82Ulnar claw (HP:0001178)2.06386888
83Vaginal atresia (HP:0000148)2.05932569
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.05636401
85Hammertoe (HP:0001765)2.05273248
86Midline defect of the nose (HP:0004122)2.04976943
87Lower limb muscle weakness (HP:0007340)2.03956671
88Supernumerary spleens (HP:0009799)2.02603555
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02103811
90Abnormal ciliary motility (HP:0012262)2.02018328
91Increased circulating renin level (HP:0000848)2.01274115
92Cupped ear (HP:0000378)2.00913633
93Difficulty running (HP:0009046)2.00376784
94Action tremor (HP:0002345)1.99483984
95Anomalous pulmonary venous return (HP:0010772)1.98177338
96Nephrogenic diabetes insipidus (HP:0009806)1.96973618
97Widely spaced teeth (HP:0000687)1.96726524
98Trigonocephaly (HP:0000243)1.96685039
99Renal hypoplasia (HP:0000089)1.96517010
100Short hallux (HP:0010109)1.95177830
101Preaxial foot polydactyly (HP:0001841)1.95034121
102Preaxial hand polydactyly (HP:0001177)1.95028079
103Broad metatarsal (HP:0001783)1.94672150
104Muscle fiber splitting (HP:0003555)1.92334960
105Poor coordination (HP:0002370)1.92330639
106Narrow forehead (HP:0000341)1.91963069
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91318510
108Abdominal situs inversus (HP:0003363)1.90806959
109Abnormality of abdominal situs (HP:0011620)1.90806959
110Short tibia (HP:0005736)1.89934334
111Limited hip movement (HP:0008800)1.89727682
112Skull defect (HP:0001362)1.89509604
113Anencephaly (HP:0002323)1.89506796
114Renal dysplasia (HP:0000110)1.89151242
115Abnormality of the parathyroid morphology (HP:0011766)1.87975948
116Morphological abnormality of the inner ear (HP:0011390)1.87456264
117Ectopic kidney (HP:0000086)1.87132170
118Scanning speech (HP:0002168)1.86915844
119Hematochezia (HP:0002573)1.85542289
120Decreased motor nerve conduction velocity (HP:0003431)1.85517860
121Abnormality of the diencephalon (HP:0010662)1.83778978
122Synostosis involving the elbow (HP:0003938)1.83671891
123Humeroradial synostosis (HP:0003041)1.83671891
124Abnormality of the pulmonary veins (HP:0011718)1.83218134
125Large earlobe (HP:0009748)1.82706127
126Conjunctival telangiectasia (HP:0000524)1.82656270
127Fibular hypoplasia (HP:0003038)1.82474075
128Capillary hemangiomas (HP:0005306)1.79357438
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.78750345
130Split foot (HP:0001839)1.78520128
131Facial shape deformation (HP:0011334)1.77620463
132Potter facies (HP:0002009)1.77620463
133Abnormality of the septum pellucidum (HP:0007375)1.76973816
134Tracheomalacia (HP:0002779)1.76966919
135Broad foot (HP:0001769)1.75654895
136Hemiplegia (HP:0002301)1.74999534
137Steppage gait (HP:0003376)1.74841714
138Hypoplastic pelvis (HP:0008839)1.73856046
139Mixed hearing impairment (HP:0000410)1.73781248
140Volvulus (HP:0002580)1.73753377
141Highly arched eyebrow (HP:0002553)1.73477988
142Abnormality of the aortic arch (HP:0012303)1.72068738
143Pheochromocytoma (HP:0002666)1.69435630
144Hemiparesis (HP:0001269)1.68830496
145Abnormality of incisor morphology (HP:0011063)1.68636409
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68261678
147Bowel incontinence (HP:0002607)1.67631787
148Stridor (HP:0010307)1.67190488
149Anterior segment dysgenesis (HP:0007700)1.66848538
150Optic nerve hypoplasia (HP:0000609)1.66835640
151Adrenal hypoplasia (HP:0000835)1.66392555
152Fair hair (HP:0002286)1.65621172
153Abnormal respiratory motile cilium physiology (HP:0012261)1.65551158
154Micropenis (HP:0000054)1.65291344
155Truncal obesity (HP:0001956)1.65290890
156Short foot (HP:0001773)1.64799762
157Wide anterior fontanel (HP:0000260)1.64664509
158Long clavicles (HP:0000890)1.64375247
159Aqueductal stenosis (HP:0002410)1.64115587
160Anophthalmia (HP:0000528)1.64040070
161Vertebral arch anomaly (HP:0008438)1.62842964
162Median cleft lip (HP:0000161)1.62117156
163Aplasia cutis congenita (HP:0001057)1.61960042
164Aplasia/Hypoplasia of the hallux (HP:0008362)1.61632998
165Amyotrophic lateral sclerosis (HP:0007354)1.61536294
166Absent hand (HP:0004050)1.61145965
167Laryngomalacia (HP:0001601)1.59833239
168Abnormal large intestine physiology (HP:0012700)1.59754149
169Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58457710
170Cerebral hypomyelination (HP:0006808)1.58128057
171Visceral angiomatosis (HP:0100761)1.57912238
172Akinesia (HP:0002304)1.57889795
173Bronchomalacia (HP:0002780)1.57855531
174Impulsivity (HP:0100710)1.57733817
175Peripheral demyelination (HP:0011096)1.57705574
176Sclerocornea (HP:0000647)1.56937132
177Pulmonary artery stenosis (HP:0004415)1.56255128
178Spastic tetraparesis (HP:0001285)1.55575132
179Myokymia (HP:0002411)1.55207728
180Male infertility (HP:0003251)1.54974147
181Hypotrichosis (HP:0001006)1.54772915
182Depressed nasal tip (HP:0000437)1.54457275
183Neoplasm of the heart (HP:0100544)1.53482052
184Abnormality of the phalanges of the hallux (HP:0010057)1.52862959
185Foot dorsiflexor weakness (HP:0009027)1.52382054
186Shallow orbits (HP:0000586)1.51010570
187Hypokalemic alkalosis (HP:0001949)1.49602467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.76565316
2EPHB14.05788669
3OXSR12.98637448
4MAP3K102.84404607
5NLK2.71762441
6MET2.51750017
7TIE12.50157622
8CASK2.46382026
9BCR2.38258169
10TYRO32.24055154
11NTRK12.21325490
12NEK92.16184484
13BRD42.09640829
14WNK42.08913910
15LATS12.04316976
16PKN11.99961987
17PAK61.92371906
18MAPKAPK51.91725167
19TGFBR11.90273131
20MARK11.82853686
21WNK11.71810615
22MAPK151.68903479
23KSR21.66533759
24KDR1.58393019
25TNIK1.58380096
26FGFR21.58045082
27FGR1.52707626
28ICK1.48327932
29CSNK1A1L1.43043782
30NEK61.39758670
31PLK21.37018970
32PINK11.34964390
33PRKD31.34165970
34MUSK1.28918616
35ROCK21.27851244
36DMPK1.26171638
37CAMK1G1.25715508
38MAP3K71.24812411
39WNK31.24643724
40MKNK21.24161920
41SGK21.22111925
42ERBB41.21298043
43FRK1.19141533
44EPHB21.15950451
45INSRR1.14467933
46PDGFRB1.14248469
47MAP3K91.12882443
48PNCK1.12658399
49BRSK21.12449962
50BMX1.10374690
51CSNK1G31.06404687
52NTRK31.02254445
53CSNK1G11.01770172
54NTRK21.01451982
55SGK4940.99751138
56SGK2230.99751138
57MARK20.95852739
58ERBB30.95054859
59CSNK1G20.94758094
60EPHA30.93536795
61DDR20.90837535
62PAK30.89351171
63LATS20.89347036
64PBK0.89021908
65UHMK10.88688183
66MAP3K60.87921092
67PTK2B0.85868949
68BMPR1B0.84893905
69CAMK2B0.84343966
70PTK20.83848326
71DYRK1A0.83064168
72MELK0.81476718
73PRKD10.80620878
74MKNK10.80126618
75MOS0.77963895
76EPHA40.77807368
77PRPF4B0.77490495
78MAP3K130.75925425
79RET0.74176450
80TRIM280.73274475
81GSK3A0.73198503
82CAMK2D0.71112620
83CAMK2A0.70297958
84CDK80.68314852
85CAMK1D0.67404999
86YES10.65195204
87PDGFRA0.64504401
88STK38L0.63680766
89CDK60.63375716
90ROCK10.62433773
91STK240.62115320
92PRKCQ0.61829443
93SGK30.61661989
94CDK50.60496669
95PHKG10.60488242
96PHKG20.60488242
97DYRK20.60296536
98STK30.60046278
99TAOK30.59531145
100CAMK2G0.57506843
101CLK10.56098450
102CDK190.55837087
103ERBB20.55299627
104CDK90.55101608
105CSK0.54983465
106CDK40.54621606
107PRKCH0.53832814
108PRKD20.53535128
109CDK120.53528897
110PDPK10.52940689
111FER0.52861297
112FYN0.52805407
113TRPM70.52466335
114LIMK10.52433955
115MAPK100.51851375
116MAPK130.50505936
117ACVR1B0.50420883
118CAMK40.49664999
119MAPK70.48918516
120WEE10.48422265
121PRKCE0.48032751
122NUAK10.46832692
123GRK10.46470214
124CDK30.44678480
125CDK140.44299783
126MAP3K40.43931173
127CSNK1D0.43055392
128KSR10.42780344
129CCNB10.42452794
130STK110.42213410
131RIPK10.40774896
132PRKAA10.40719310
133DYRK1B0.38967519
134INSR0.38553684
135CDK150.37182326
136PTK60.37104156
137ABL10.36916020
138CAMK10.36848312
139TGFBR20.36378405
140PRKAA20.36180771
141BLK0.33899247
142ATM0.33550132
143IRAK10.33278318
144NEK20.33078825
145EGFR0.32905249
146MAP2K70.32701365
147CHUK0.32545950

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.13812291
2Steroid biosynthesis_Homo sapiens_hsa001002.89164315
3Axon guidance_Homo sapiens_hsa043602.34690619
4Dorso-ventral axis formation_Homo sapiens_hsa043202.21119798
5Fatty acid elongation_Homo sapiens_hsa000622.16711493
6Ether lipid metabolism_Homo sapiens_hsa005652.15415143
7Renal cell carcinoma_Homo sapiens_hsa052111.70196970
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62332363
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61786340
10ECM-receptor interaction_Homo sapiens_hsa045121.58621020
11Colorectal cancer_Homo sapiens_hsa052101.47366851
12Lysine degradation_Homo sapiens_hsa003101.40849414
13Hedgehog signaling pathway_Homo sapiens_hsa043401.33191638
14Tight junction_Homo sapiens_hsa045301.32411464
15Nitrogen metabolism_Homo sapiens_hsa009101.31922022
16Ovarian steroidogenesis_Homo sapiens_hsa049131.31284175
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29589288
18Protein digestion and absorption_Homo sapiens_hsa049741.27040300
19Endometrial cancer_Homo sapiens_hsa052131.26909546
20Long-term depression_Homo sapiens_hsa047301.25150460
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23779001
22Glutamatergic synapse_Homo sapiens_hsa047241.23173258
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.22788516
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20683463
25Focal adhesion_Homo sapiens_hsa045101.20382033
26Hippo signaling pathway_Homo sapiens_hsa043901.14864409
27ABC transporters_Homo sapiens_hsa020101.14656250
28Basal cell carcinoma_Homo sapiens_hsa052171.14250633
29Ras signaling pathway_Homo sapiens_hsa040141.14190739
30Sphingolipid metabolism_Homo sapiens_hsa006001.13049340
31GABAergic synapse_Homo sapiens_hsa047271.12137644
32Alcoholism_Homo sapiens_hsa050341.11167415
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10175487
34Fanconi anemia pathway_Homo sapiens_hsa034601.09109794
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08353811
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.08130185
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.07376329
38Serotonergic synapse_Homo sapiens_hsa047261.06367574
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05066441
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02495315
41Linoleic acid metabolism_Homo sapiens_hsa005911.02074383
42Phototransduction_Homo sapiens_hsa047440.99153747
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98898681
44Adherens junction_Homo sapiens_hsa045200.98724659
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98250983
46Notch signaling pathway_Homo sapiens_hsa043300.97783476
47ErbB signaling pathway_Homo sapiens_hsa040120.97353019
48Endocytosis_Homo sapiens_hsa041440.96463130
49TGF-beta signaling pathway_Homo sapiens_hsa043500.95561986
50Choline metabolism in cancer_Homo sapiens_hsa052310.95175511
51Cell cycle_Homo sapiens_hsa041100.94507180
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94379031
53Rap1 signaling pathway_Homo sapiens_hsa040150.94220626
54Amoebiasis_Homo sapiens_hsa051460.94182818
55Cocaine addiction_Homo sapiens_hsa050300.93844281
56Basal transcription factors_Homo sapiens_hsa030220.93048121
57Caffeine metabolism_Homo sapiens_hsa002320.89825998
58VEGF signaling pathway_Homo sapiens_hsa043700.88911289
59Olfactory transduction_Homo sapiens_hsa047400.88430114
60Circadian entrainment_Homo sapiens_hsa047130.87639747
61Dilated cardiomyopathy_Homo sapiens_hsa054140.86788878
62cAMP signaling pathway_Homo sapiens_hsa040240.86650391
63Circadian rhythm_Homo sapiens_hsa047100.86149021
64Salivary secretion_Homo sapiens_hsa049700.85177343
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83236695
66Propanoate metabolism_Homo sapiens_hsa006400.82731566
67Melanogenesis_Homo sapiens_hsa049160.82409705
68Proteoglycans in cancer_Homo sapiens_hsa052050.82294723
69Gastric acid secretion_Homo sapiens_hsa049710.82232190
70Butanoate metabolism_Homo sapiens_hsa006500.82227899
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82066251
72Malaria_Homo sapiens_hsa051440.82048098
73FoxO signaling pathway_Homo sapiens_hsa040680.81448217
74Estrogen signaling pathway_Homo sapiens_hsa049150.81047317
75Rheumatoid arthritis_Homo sapiens_hsa053230.80892178
76GnRH signaling pathway_Homo sapiens_hsa049120.80771592
77Renin secretion_Homo sapiens_hsa049240.80403978
78Thyroid cancer_Homo sapiens_hsa052160.79798789
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79395945
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.77970468
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77840256
82Melanoma_Homo sapiens_hsa052180.77707079
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77016635
84Nicotine addiction_Homo sapiens_hsa050330.76619948
85Fatty acid biosynthesis_Homo sapiens_hsa000610.76432450
86Taste transduction_Homo sapiens_hsa047420.76273512
87Morphine addiction_Homo sapiens_hsa050320.75651160
88Gap junction_Homo sapiens_hsa045400.75052046
89MAPK signaling pathway_Homo sapiens_hsa040100.73466521
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73021471
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71626403
92Oocyte meiosis_Homo sapiens_hsa041140.71163895
93MicroRNAs in cancer_Homo sapiens_hsa052060.71081550
94Cholinergic synapse_Homo sapiens_hsa047250.70930264
95p53 signaling pathway_Homo sapiens_hsa041150.70123980
96Wnt signaling pathway_Homo sapiens_hsa043100.69290486
97Inositol phosphate metabolism_Homo sapiens_hsa005620.67758001
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67220744
99Pancreatic cancer_Homo sapiens_hsa052120.66945337
100Pathways in cancer_Homo sapiens_hsa052000.66603487
101B cell receptor signaling pathway_Homo sapiens_hsa046620.66566238
102Chemokine signaling pathway_Homo sapiens_hsa040620.66257116
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66078498
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65235605
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65149429
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65004575
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64951915
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.63555363
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63414595
110Long-term potentiation_Homo sapiens_hsa047200.62267452
111Oxytocin signaling pathway_Homo sapiens_hsa049210.61537280
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61460654
113Bile secretion_Homo sapiens_hsa049760.61076465
114Thyroid hormone synthesis_Homo sapiens_hsa049180.59973523
115Small cell lung cancer_Homo sapiens_hsa052220.59800837
116African trypanosomiasis_Homo sapiens_hsa051430.59731436
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58692432
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57478389
119Amphetamine addiction_Homo sapiens_hsa050310.57183976
120Mineral absorption_Homo sapiens_hsa049780.56316494
121Histidine metabolism_Homo sapiens_hsa003400.56292035
122Prostate cancer_Homo sapiens_hsa052150.55559146
123Dopaminergic synapse_Homo sapiens_hsa047280.54652666
124Type II diabetes mellitus_Homo sapiens_hsa049300.54530934
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53561472
126Prion diseases_Homo sapiens_hsa050200.52328709
127Glioma_Homo sapiens_hsa052140.51515050
128TNF signaling pathway_Homo sapiens_hsa046680.51325316
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51267639
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50971014
131Platelet activation_Homo sapiens_hsa046110.49874557
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49787619
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49699581
134Calcium signaling pathway_Homo sapiens_hsa040200.49684842
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48972406
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48247201
137Systemic lupus erythematosus_Homo sapiens_hsa053220.47690642
138Chronic myeloid leukemia_Homo sapiens_hsa052200.47305061
139Fatty acid metabolism_Homo sapiens_hsa012120.45749588
140Salmonella infection_Homo sapiens_hsa051320.45732333

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