PLEKHG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fatty acid transport (GO:2000192)4.03732999
2positive thymic T cell selection (GO:0045059)3.87208221
3positive regulation of fatty acid beta-oxidation (GO:0032000)3.77162897
4positive regulation of gamma-delta T cell activation (GO:0046645)3.44974452
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.37388230
6regulation of translation, ncRNA-mediated (GO:0045974)3.37388230
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.37388230
8histone H3-K4 trimethylation (GO:0080182)3.28575375
9cochlea morphogenesis (GO:0090103)3.28235604
10cell proliferation in forebrain (GO:0021846)3.25766821
11thymic T cell selection (GO:0045061)3.25359891
12negative T cell selection (GO:0043383)3.24504788
13semaphorin-plexin signaling pathway (GO:0071526)3.22517322
14positive regulation of protein kinase C signaling (GO:0090037)3.21499657
15negative regulation of axon extension involved in axon guidance (GO:0048843)3.20082456
16negative thymic T cell selection (GO:0045060)3.19397476
17positive T cell selection (GO:0043368)3.19245863
18regulation of T cell tolerance induction (GO:0002664)3.17833160
19regulation of axon extension involved in axon guidance (GO:0048841)3.17347432
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10885028
21positive regulation of fatty acid oxidation (GO:0046321)3.09626400
22regulation of gamma-delta T cell differentiation (GO:0045586)3.08882317
23convergent extension (GO:0060026)3.06696282
24endothelial cell chemotaxis (GO:0035767)3.01204217
25T cell selection (GO:0045058)2.99545056
26regulation of axon guidance (GO:1902667)2.98791927
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97060385
28neuronal stem cell maintenance (GO:0097150)2.93531051
29lymphangiogenesis (GO:0001946)2.92847169
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92801081
31negative regulation of axon guidance (GO:1902668)2.90908489
32regulation of gamma-delta T cell activation (GO:0046643)2.89471617
33lymph vessel development (GO:0001945)2.88869962
34pericardium development (GO:0060039)2.86184230
35positive regulation of gene expression, epigenetic (GO:0045815)2.85654570
36leukocyte aggregation (GO:0070486)2.84235214
37kidney mesenchyme development (GO:0072074)2.84138538
38spinal cord development (GO:0021510)2.83886261
39positive regulation of epithelial to mesenchymal transition (GO:0010718)2.83269041
40mannose metabolic process (GO:0006013)2.81425225
41camera-type eye morphogenesis (GO:0048593)2.80905726
42regulation of fatty acid beta-oxidation (GO:0031998)2.80782092
43heterochromatin organization (GO:0070828)2.80116378
44radial glial cell differentiation (GO:0060019)2.79577941
45positive regulation of CREB transcription factor activity (GO:0032793)2.78029770
46positive regulation of tolerance induction (GO:0002645)2.77617973
47negative regulation of catenin import into nucleus (GO:0035414)2.72093763
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71513678
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71513678
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71025163
51dermatan sulfate metabolic process (GO:0030205)2.70722378
52regulation of posttranscriptional gene silencing (GO:0060147)2.70470363
53regulation of gene silencing by miRNA (GO:0060964)2.70470363
54regulation of gene silencing by RNA (GO:0060966)2.70470363
55cranial nerve morphogenesis (GO:0021602)2.70161426
56neural tube development (GO:0021915)2.68643565
57endocardial cushion morphogenesis (GO:0003203)2.67993722
58glomerular basement membrane development (GO:0032836)2.67817105
59facial nerve structural organization (GO:0021612)2.67282365
60protein heterotrimerization (GO:0070208)2.66420597
61morphogenesis of an endothelium (GO:0003159)2.65890178
62endothelial tube morphogenesis (GO:0061154)2.65890178
63regulation of hippo signaling (GO:0035330)2.64998394
64cell proliferation involved in metanephros development (GO:0072203)2.64784143
65regulation of glucose import in response to insulin stimulus (GO:2001273)2.63533264
66planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63197391
67heart valve formation (GO:0003188)2.62769628
68mesenchyme morphogenesis (GO:0072132)2.62400520
69aorta morphogenesis (GO:0035909)2.60535474
70metanephric mesenchyme development (GO:0072075)2.59781052
71positive regulation of odontogenesis (GO:0042482)2.59523799
72T cell migration (GO:0072678)2.59066249
73antigen processing and presentation of endogenous antigen (GO:0019883)2.58588583
74dermatan sulfate biosynthetic process (GO:0030208)2.58359623
75cell migration in hindbrain (GO:0021535)2.56396771
76bone trabecula formation (GO:0060346)2.56272990
77regulation of apoptotic process involved in morphogenesis (GO:1902337)2.55117110
78mesenchymal cell development (GO:0014031)2.54570190
79vascular endothelial growth factor signaling pathway (GO:0038084)2.52195775
80cell migration involved in sprouting angiogenesis (GO:0002042)2.51024968
81positive regulation of endothelial cell apoptotic process (GO:2000353)2.50585945
82regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50221974
83regulation of tolerance induction (GO:0002643)2.47177410
84chondrocyte proliferation (GO:0035988)2.45840406
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.45616404
86SMAD protein complex assembly (GO:0007183)2.45279349
87histone H3-K9 methylation (GO:0051567)2.45042750
88paraxial mesoderm development (GO:0048339)2.44638461
89basement membrane organization (GO:0071711)2.43841223
90positive regulation by host of viral transcription (GO:0043923)2.41862892
91white fat cell differentiation (GO:0050872)2.41134687
92venous blood vessel morphogenesis (GO:0048845)2.40225852
93neural crest cell development (GO:0014032)2.39867659
94tolerance induction (GO:0002507)2.39511156
95endodermal cell differentiation (GO:0035987)2.38130682
96trophoblast giant cell differentiation (GO:0060707)2.37525756
97mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37465647
98glomerulus development (GO:0032835)2.36425100
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35059788
100negative regulation of cell killing (GO:0031342)2.35059788
101somatic stem cell division (GO:0048103)2.34923574
102cell migration involved in heart development (GO:0060973)2.34058935
103heart morphogenesis (GO:0003007)2.32850647
104cardiovascular system development (GO:0072358)2.31915616
105regulation of SMAD protein import into nucleus (GO:0060390)2.30723317
106positive regulation of gastrulation (GO:2000543)2.29758524
107outer ear morphogenesis (GO:0042473)2.29530215
108urinary tract smooth muscle contraction (GO:0014848)2.29494376
109cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28875911
110histone H3-K9 modification (GO:0061647)2.28726099
111negative chemotaxis (GO:0050919)2.28284454
112hippo signaling (GO:0035329)2.28127732
113interferon-gamma production (GO:0032609)2.27168215
114cell proliferation involved in kidney development (GO:0072111)2.26032507
115regulation of catenin import into nucleus (GO:0035412)2.25965391
116behavioral response to nicotine (GO:0035095)2.25960638
117eye morphogenesis (GO:0048592)2.25672856
118tongue development (GO:0043586)2.25578682
119positive regulation of glycogen biosynthetic process (GO:0045725)2.24885818
120NIK/NF-kappaB signaling (GO:0038061)2.24865689
121neuron projection extension involved in neuron projection guidance (GO:1902284)2.24190677
122axon extension involved in axon guidance (GO:0048846)2.24190677
123regulation of stem cell maintenance (GO:2000036)2.23211902
124artery morphogenesis (GO:0048844)2.23010820
125wound healing, spreading of epidermal cells (GO:0035313)2.22613194
126anatomical structure regression (GO:0060033)2.22494933
127response to laminar fluid shear stress (GO:0034616)2.20917866
128cell fate commitment involved in formation of primary germ layer (GO:0060795)2.20872876
129regulation of establishment of planar polarity (GO:0090175)2.20643348
130negative regulation of chondrocyte differentiation (GO:0032331)2.19920621
131apoptotic process involved in morphogenesis (GO:0060561)2.19757949
132renal system development (GO:0072001)2.19709011
133germ cell migration (GO:0008354)2.19672836
134positive regulation of interleukin-8 secretion (GO:2000484)2.18648859
135stem cell development (GO:0048864)2.18362192
136regulation of protein heterodimerization activity (GO:0043497)2.18249611
137negative regulation of stress fiber assembly (GO:0051497)2.18101005
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15089159
139T cell receptor signaling pathway (GO:0050852)2.15065566
140Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.13727764
141face morphogenesis (GO:0060325)2.13020196
142epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.11775690
143atrioventricular valve morphogenesis (GO:0003181)2.10922866
144substrate-dependent cell migration (GO:0006929)2.10838923
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.10605539
146positive regulation of histone deacetylation (GO:0031065)2.08231155
147patterning of blood vessels (GO:0001569)2.07765483
148positive regulation of blood vessel endothelial cell migration (GO:0043536)2.06886056
149negative regulation of phagocytosis (GO:0050765)2.06718040
150positive regulation of stem cell differentiation (GO:2000738)2.06094001
151collagen fibril organization (GO:0030199)2.04180281
152mesodermal cell differentiation (GO:0048333)2.03356006
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.01524918
154pre-miRNA processing (GO:0031054)2.01019598
155glomerular visceral epithelial cell development (GO:0072015)1.99257060
156T cell costimulation (GO:0031295)1.99231429
157lateral sprouting from an epithelium (GO:0060601)1.98342757
158polarized epithelial cell differentiation (GO:0030859)1.97623093
159negative regulation of erythrocyte differentiation (GO:0045647)1.97212859
160cell-substrate junction assembly (GO:0007044)1.97017216
161antigen receptor-mediated signaling pathway (GO:0050851)1.95791569
162lymphocyte costimulation (GO:0031294)1.95601849
163regulation of extracellular matrix disassembly (GO:0010715)1.95550070
164eyelid development in camera-type eye (GO:0061029)1.95126775
165regulation of alpha-beta T cell proliferation (GO:0046640)1.94800555
166non-canonical Wnt signaling pathway (GO:0035567)1.94691102
167atrial septum morphogenesis (GO:0060413)1.93948658
168positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.93372209
169response to muramyl dipeptide (GO:0032495)1.93201652
170embryonic foregut morphogenesis (GO:0048617)1.92738368
171V(D)J recombination (GO:0033151)1.92397722
172response to interleukin-15 (GO:0070672)1.91902238
173regulation of B cell receptor signaling pathway (GO:0050855)1.91570020
174dosage compensation (GO:0007549)1.91559526
175leukocyte cell-cell adhesion (GO:0007159)1.91455382
176regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.91141716
177head development (GO:0060322)1.90027318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.20795767
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.51264289
3EZH2_22144423_ChIP-Seq_EOC_Human4.34516419
4MYC_22102868_ChIP-Seq_BL_Human3.61482836
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58407200
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52172928
7* EGR1_19374776_ChIP-ChIP_THP-1_Human3.41421062
8E2F7_22180533_ChIP-Seq_HELA_Human3.35494656
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.96597357
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83456625
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69827856
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.62383334
13* VDR_21846776_ChIP-Seq_THP-1_Human2.59105751
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.57187058
15MAF_26560356_Chip-Seq_TH1_Human2.55898608
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42696075
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.41329867
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40587654
19UTX_26944678_Chip-Seq_JUKART_Human2.39455913
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.30869893
21* KDM2B_26808549_Chip-Seq_DND41_Human2.29248790
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28876131
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.28734447
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26040420
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.25189008
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.22665659
27RUNX_20019798_ChIP-Seq_JUKART_Human2.18374620
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16360214
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.15458099
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12566175
31TP53_20018659_ChIP-ChIP_R1E_Mouse2.10837481
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.09356263
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.08793651
34DROSHA_22980978_ChIP-Seq_HELA_Human2.08717259
35TRIM28_21343339_ChIP-Seq_HEK293_Human2.08224689
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06890944
37RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04882255
38EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04882255
39JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00367058
40MYB_26560356_Chip-Seq_TH2_Human1.99144510
41VDR_24763502_ChIP-Seq_THP-1_Human1.98558983
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91994868
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91161842
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90055989
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87368925
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85475237
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85159283
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.80034541
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77839678
50MYB_26560356_Chip-Seq_TH1_Human1.77367775
51* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76659556
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.72053162
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70829741
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.70742326
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67870442
56* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67856559
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66004829
58SCL_19346495_ChIP-Seq_HPC-7_Human1.65334320
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56317921
60* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56144509
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.52941433
62MAF_26560356_Chip-Seq_TH2_Human1.52626376
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50042274
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49728718
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.49654784
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48110871
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.47871855
68CTCF_27219007_Chip-Seq_Bcells_Human1.47859194
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47672917
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47295354
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46487553
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46457845
73* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46176846
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44246215
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.43818621
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40299491
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40161004
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40071979
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40064812
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38001230
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37802932
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35610341
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.35038211
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34390079
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34386902
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34041458
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.32668916
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31272630
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30271638
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30262735
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29533189
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.23439720
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23360576
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.22588906
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22465872
96CLOCK_20551151_ChIP-Seq_293T_Human1.21547761
97P68_20966046_ChIP-Seq_HELA_Human1.21490349
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.21020922
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.20879058
100RACK7_27058665_Chip-Seq_MCF-7_Human1.20585303
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20581517
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.20081239
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20071588
104CIITA_25753668_ChIP-Seq_RAJI_Human1.19565353
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19493966
106SPI1_23127762_ChIP-Seq_K562_Human1.19410727
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19396629
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18437369
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17958734
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17907256
111* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17864660
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17725100
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16811701
114NCOR1_26117541_ChIP-Seq_K562_Human1.15909359
115BP1_19119308_ChIP-ChIP_Hs578T_Human1.15075827
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14961275
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14784586
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14140799
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.13463475
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13313178
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13313178
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12964045
123* CREB1_26743006_Chip-Seq_LNCaP_Human1.12939046
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12162337
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09000889
126MYC_27129775_Chip-Seq_CORNEA_Mouse1.07942060
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07926937
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07926937
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07926937
130LXR_22292898_ChIP-Seq_THP-1_Human1.07712569
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07336175
132* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06481346
133SPI1_23547873_ChIP-Seq_NB4_Human1.04686936
134BRD4_25478319_ChIP-Seq_HGPS_Human1.04558780
135SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03251926
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02895114
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00531650
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.99394612
139E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98712318
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98705140
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98276170
142TP53_22127205_ChIP-Seq_IMR90_Human0.97344805
143* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97318836
144* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95967577
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95326273
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.94123372
147FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94078836
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93981197
149* KDM2B_26808549_Chip-Seq_K562_Human0.93651639
150SMC4_20622854_ChIP-Seq_HELA_Human0.92703809
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91924690
152OCT4_19829295_ChIP-Seq_ESCs_Human0.91416516
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91386152
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.91223729
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.91223729
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.90862071
157RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90755356
158ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90526486
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88748190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen2.97846464
2MP0003283_abnormal_digestive_organ2.78608523
3MP0002254_reproductive_system_inflammat2.47831069
4MP0003763_abnormal_thymus_physiology2.36344535
5MP0003279_aneurysm2.29031464
6MP0004272_abnormal_basement_membrane2.25961723
7MP0010030_abnormal_orbit_morphology2.02125788
8MP0005503_abnormal_tendon_morphology1.90997421
9MP0010352_gastrointestinal_tract_polyps1.88489368
10MP0009278_abnormal_bone_marrow1.85511356
11MP0003303_peritoneal_inflammation1.82209502
12MP0005275_abnormal_skin_tensile1.79000430
13MP0003385_abnormal_body_wall1.75806126
14MP0000534_abnormal_ureter_morphology1.74650109
15MP0000685_abnormal_immune_system1.74571995
16MP0003705_abnormal_hypodermis_morpholog1.74191824
17MP0005076_abnormal_cell_differentiation1.73498054
18MP0001299_abnormal_eye_distance/1.70948280
19MP0003566_abnormal_cell_adhesion1.70177429
20MP0002653_abnormal_ependyma_morphology1.67839425
21MP0004133_heterotaxia1.65830741
22MP0002166_altered_tumor_susceptibility1.62871804
23MP0005257_abnormal_intraocular_pressure1.61411152
24MP0009333_abnormal_splenocyte_physiolog1.61066825
25MP0002396_abnormal_hematopoietic_system1.60464717
26MP0000733_abnormal_muscle_development1.58763622
27MP0004808_abnormal_hematopoietic_stem1.52656091
28MP0002933_joint_inflammation1.52492833
29MP0000778_abnormal_nervous_system1.49551285
30MP0001958_emphysema1.48318279
31MP0004130_abnormal_muscle_cell1.46340914
32MP0003300_gastrointestinal_ulcer1.45669482
33MP0009384_cardiac_valve_regurgitation1.45587511
34MP0005023_abnormal_wound_healing1.44055079
35MP0009053_abnormal_anal_canal1.43117024
36MP0004858_abnormal_nervous_system1.41959277
37MP0005387_immune_system_phenotype1.41459518
38MP0001790_abnormal_immune_system1.41459518
39MP0000566_synostosis1.40334886
40MP0005623_abnormal_meninges_morphology1.40328855
41MP0001800_abnormal_humoral_immune1.39080749
42MP0005671_abnormal_response_to1.39060801
43MP0006292_abnormal_olfactory_placode1.38795651
44MP0000767_abnormal_smooth_muscle1.38777007
45MP0003119_abnormal_digestive_system1.38291949
46MP0003136_yellow_coat_color1.36972958
47MP0005595_abnormal_vascular_smooth1.35516150
48MP0006054_spinal_hemorrhage1.34877648
49MP0003091_abnormal_cell_migration1.33652450
50MP0004185_abnormal_adipocyte_glucose1.33234781
51MP0001879_abnormal_lymphatic_vessel1.29248977
52MP0003941_abnormal_skin_development1.28243451
53MP0002928_abnormal_bile_duct1.28197162
54MP0000703_abnormal_thymus_morphology1.25584957
55MP0002398_abnormal_bone_marrow1.24875112
56MP0002697_abnormal_eye_size1.24796007
57MP0002092_abnormal_eye_morphology1.24100168
58MP0002006_tumorigenesis1.22699845
59MP0000428_abnormal_craniofacial_morphol1.22638534
60MP0002452_abnormal_antigen_presenting1.22535010
61MP0001835_abnormal_antigen_presentation1.21032558
62MP0003828_pulmonary_edema1.20241827
63MP0001286_abnormal_eye_development1.19625429
64MP0005000_abnormal_immune_tolerance1.19114514
65MP0002420_abnormal_adaptive_immunity1.17864229
66MP0000049_abnormal_middle_ear1.17227760
67MP0001819_abnormal_immune_cell1.16418462
68MP0000537_abnormal_urethra_morphology1.15718401
69MP0003567_abnormal_fetal_cardiomyocyte1.15489746
70MP0002108_abnormal_muscle_morphology1.15281643
71MP0002932_abnormal_joint_morphology1.15042875
72MP0003436_decreased_susceptibility_to1.14914248
73MP0010368_abnormal_lymphatic_system1.14765665
74MP0002925_abnormal_cardiovascular_devel1.13129910
75MP0002249_abnormal_larynx_morphology1.12079535
76MP0001270_distended_abdomen1.11540438
77MP0003861_abnormal_nervous_system1.10772632
78MP0002405_respiratory_system_inflammati1.10446038
79MP0002138_abnormal_hepatobiliary_system1.09503316
80MP0008961_abnormal_basal_metabolism1.09495342
81MP0000026_abnormal_inner_ear1.09349742
82MP0003935_abnormal_craniofacial_develop1.08410811
83MP0002723_abnormal_immune_serum1.08028588
84MP0005508_abnormal_skeleton_morphology1.07371468
85MP0009250_abnormal_appendicular_skeleto1.06885345
86MP0002111_abnormal_tail_morphology1.04696153
87MP0000163_abnormal_cartilage_morphology1.04063492
88MP0000716_abnormal_immune_system1.03743738
89MP0001293_anophthalmia1.02722325
90MP0003938_abnormal_ear_development1.02214014
91MP0003942_abnormal_urinary_system1.00671669
92MP0001873_stomach_inflammation1.00600976
93MP0002114_abnormal_axial_skeleton1.00153065
94MP0001348_abnormal_lacrimal_gland0.99454192
95MP0002722_abnormal_immune_system0.98870180
96MP0003115_abnormal_respiratory_system0.98849371
97MP0000490_abnormal_crypts_of0.98436201
98MP0002089_abnormal_postnatal_growth/wei0.98180714
99MP0010155_abnormal_intestine_physiology0.97394490
100MP0004947_skin_inflammation0.97348505
101MP0000432_abnormal_head_morphology0.96043784
102MP0003448_altered_tumor_morphology0.96037003
103MP0004510_myositis0.94665846
104MP0002109_abnormal_limb_morphology0.94515348
105MP0006138_congestive_heart_failure0.94509514
106MP0001849_ear_inflammation0.94483274
107MP0004197_abnormal_fetal_growth/weight/0.94458740
108MP0003724_increased_susceptibility_to0.94297031
109MP0002009_preneoplasia0.94194869
110MP0005409_darkened_coat_color0.93475972
111MP0009785_altered_susceptibility_to0.92225324
112MP0008007_abnormal_cellular_replicative0.91983616
113MP0000858_altered_metastatic_potential0.91982608
114MP0004134_abnormal_chest_morphology0.91338890
115MP0000689_abnormal_spleen_morphology0.89826937
116MP0002282_abnormal_trachea_morphology0.89725350
117MP0001614_abnormal_blood_vessel0.88870393
118MP0003122_maternal_imprinting0.88214654
119MP0003890_abnormal_embryonic-extraembry0.87495866
120MP0004381_abnormal_hair_follicle0.87287937
121MP0001243_abnormal_dermal_layer0.87189573
122MP0002429_abnormal_blood_cell0.86559879
123MP0005025_abnormal_response_to0.86521790
124MP0005390_skeleton_phenotype0.85937991
125MP0005377_hearing/vestibular/ear_phenot0.85917711
126MP0003878_abnormal_ear_physiology0.85917711
127MP0002085_abnormal_embryonic_tissue0.85707584
128MP0002081_perinatal_lethality0.85379533
129MP0003937_abnormal_limbs/digits/tail_de0.85271139
130MP0002148_abnormal_hypersensitivity_rea0.84102853
131MP0002060_abnormal_skin_morphology0.83193066
132MP0002128_abnormal_blood_circulation0.81873477
133MP0002184_abnormal_innervation0.80871588
134MP0010630_abnormal_cardiac_muscle0.80741695
135MP0003755_abnormal_palate_morphology0.80449869
136MP0000750_abnormal_muscle_regeneration0.80405064
137MP0000003_abnormal_adipose_tissue0.80052102
138MP0002116_abnormal_craniofacial_bone0.79758901
139MP0002113_abnormal_skeleton_development0.79569225
140MP0000462_abnormal_digestive_system0.79439173
141MP0003045_fibrosis0.79417614
142MP0001915_intracranial_hemorrhage0.79083873
143MP0003948_abnormal_gas_homeostasis0.78264382
144MP0002115_abnormal_skeleton_extremities0.76775712
145MP0002233_abnormal_nose_morphology0.73833667
146MP0005381_digestive/alimentary_phenotyp0.73673250
147MP0000631_abnormal_neuroendocrine_gland0.73067032
148MP0000955_abnormal_spinal_cord0.70293160
149MP0000470_abnormal_stomach_morphology0.69819245
150MP0002752_abnormal_somatic_nervous0.67014678
151MP0005670_abnormal_white_adipose0.66491268

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.01582574
2Short 4th metacarpal (HP:0010044)3.80118088
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.80118088
4Shallow orbits (HP:0000586)3.61323978
5Premature rupture of membranes (HP:0001788)3.47009248
6Ankle contracture (HP:0006466)3.30172890
7Genetic anticipation (HP:0003743)3.30030767
8Hypoplastic ischia (HP:0003175)3.20551289
9Neonatal hypoglycemia (HP:0001998)3.12299728
10Aortic dissection (HP:0002647)3.12009120
11Abnormality of the 4th metacarpal (HP:0010012)2.93325933
12Broad metatarsal (HP:0001783)2.92869250
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92759106
14Abnormality of the ischium (HP:0003174)2.82184450
15Atrophic scars (HP:0001075)2.71864606
16Cerebral aneurysm (HP:0004944)2.69947032
17Aortic aneurysm (HP:0004942)2.67363309
18Abnormality of the fingertips (HP:0001211)2.61314847
19Vitreoretinal degeneration (HP:0000655)2.57039799
20Rib fusion (HP:0000902)2.52519540
21Dilatation of the ascending aorta (HP:0005111)2.47673042
22Wrist flexion contracture (HP:0001239)2.46378058
23Obstructive sleep apnea (HP:0002870)2.44660665
24Bladder diverticulum (HP:0000015)2.44283076
25Hyperacusis (HP:0010780)2.37250288
26Large for gestational age (HP:0001520)2.35901151
27Abnormality of the aortic arch (HP:0012303)2.34301281
28Patellar aplasia (HP:0006443)2.32571880
29Renovascular hypertension (HP:0100817)2.32508938
30Peritonitis (HP:0002586)2.31193417
31Mitral valve prolapse (HP:0001634)2.29905829
32Arterial tortuosity (HP:0005116)2.25334037
33Trigonocephaly (HP:0000243)2.24915792
34Dislocated radial head (HP:0003083)2.19933622
35Renal duplication (HP:0000075)2.18957184
36Aplasia/Hypoplasia of the patella (HP:0006498)2.17344832
37Abnormality of the peritoneum (HP:0002585)2.17171967
38Bicuspid aortic valve (HP:0001647)2.17164249
39Vascular tortuosity (HP:0004948)2.17150933
40Spinal cord lesions (HP:0100561)2.16457431
41Syringomyelia (HP:0003396)2.16457431
42Selective tooth agenesis (HP:0001592)2.15360531
43Mitral regurgitation (HP:0001653)2.14278010
44Aortic regurgitation (HP:0001659)2.12781184
45Turricephaly (HP:0000262)2.11328486
46Broad phalanges of the hand (HP:0009768)2.11037702
47Abnormality of the radial head (HP:0003995)2.10349802
48T lymphocytopenia (HP:0005403)2.09846617
49Fragile skin (HP:0001030)2.09408987
50Asymmetry of the thorax (HP:0001555)2.09055229
51Abnormality of the incisor (HP:0000676)2.08691641
52Broad face (HP:0000283)2.07096103
53Increased density of long bones (HP:0006392)2.06909865
54Long eyelashes (HP:0000527)2.06907970
55Joint contractures involving the joints of the feet (HP:0100492)2.06578490
56Flexion contracture of toe (HP:0005830)2.06578490
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.06362202
58Morphological abnormality of the middle ear (HP:0008609)2.04919976
59Broad long bones (HP:0005622)2.03405491
60Bronchomalacia (HP:0002780)2.03378338
61Abnormality of T cell number (HP:0011839)2.02824830
62Broad finger (HP:0001500)2.02098062
63Ureteral stenosis (HP:0000071)2.01493698
64Mesomelia (HP:0003027)2.01269310
65Disproportionate tall stature (HP:0001519)1.99387239
66Thin ribs (HP:0000883)1.99306903
67Broad phalanx (HP:0006009)1.98950539
68Camptodactyly of toe (HP:0001836)1.97325606
69Soft skin (HP:0000977)1.97279282
70Shawl scrotum (HP:0000049)1.97230891
71Hypoplasia of the maxilla (HP:0000327)1.97139195
72Elevated erythrocyte sedimentation rate (HP:0003565)1.96319157
73Persistence of primary teeth (HP:0006335)1.94192228
74Panhypogammaglobulinemia (HP:0003139)1.93983941
75Supernumerary ribs (HP:0005815)1.92941294
76Protruding tongue (HP:0010808)1.92367553
77Broad palm (HP:0001169)1.92279409
78Abnormality of the parietal bone (HP:0002696)1.91655711
79Bulbous nose (HP:0000414)1.91607348
80Lymphangioma (HP:0100764)1.91466296
81Elfin facies (HP:0004428)1.91088156
82Abnormality of the pubic bones (HP:0003172)1.90826442
83Genu recurvatum (HP:0002816)1.90176823
84Recurrent bronchitis (HP:0002837)1.88597320
85Ureteral obstruction (HP:0006000)1.87167758
86Broad toe (HP:0001837)1.86837438
87Midline defect of the nose (HP:0004122)1.84947988
88Coronal craniosynostosis (HP:0004440)1.84910414
89Deviation of the hallux (HP:0010051)1.83827606
90Abnormality of the intervertebral disk (HP:0005108)1.83471501
91Abnormality of dentin (HP:0010299)1.82225127
92Abnormality of the columella (HP:0009929)1.80978120
93Spina bifida occulta (HP:0003298)1.80909805
94Spondylolisthesis (HP:0003302)1.80848793
95Ectopic kidney (HP:0000086)1.80197054
96Broad hallux (HP:0010055)1.79581181
97Mesangial abnormality (HP:0001966)1.78799743
98Blue sclerae (HP:0000592)1.77579096
99Bowel diverticulosis (HP:0005222)1.76155547
100Megalocornea (HP:0000485)1.75452061
101Pulmonary artery stenosis (HP:0004415)1.75170707
102Hallux valgus (HP:0001822)1.74914677
103Emphysema (HP:0002097)1.74547613
104Narrow palate (HP:0000189)1.74431296
105Neonatal short-limb short stature (HP:0008921)1.74263422
106Wide anterior fontanel (HP:0000260)1.73853962
107Aortic valve stenosis (HP:0001650)1.72589391
108Abnormality of incisor morphology (HP:0011063)1.71487391
109Preaxial foot polydactyly (HP:0001841)1.70891976
110Aplasia cutis congenita (HP:0001057)1.70690689
111Thin bony cortex (HP:0002753)1.70488626
112Hypoventilation (HP:0002791)1.70388088
113Narrow nasal bridge (HP:0000446)1.70160944
114Ulnar bowing (HP:0003031)1.69197068
115Abnormality of the diencephalon (HP:0010662)1.69142328
116Type 1 muscle fiber predominance (HP:0003803)1.68324372
117Broad ribs (HP:0000885)1.67970740
118Flat cornea (HP:0007720)1.66679628
119Agammaglobulinemia (HP:0004432)1.66635269
120Skull defect (HP:0001362)1.66472006
121Truncal obesity (HP:0001956)1.66391447
122Deviation of the thumb (HP:0009603)1.64865765
123Clumsiness (HP:0002312)1.64791986
124Spinal rigidity (HP:0003306)1.64743411
125Cellulitis (HP:0100658)1.64301550
126Rectal prolapse (HP:0002035)1.63968739
127Abnormality of the humeroradial joint (HP:0100744)1.63914618
128Chronic otitis media (HP:0000389)1.63534711
129Elbow flexion contracture (HP:0002987)1.63384072
130Slender build (HP:0001533)1.63341970
131Hematochezia (HP:0002573)1.62638874
132Ectopia lentis (HP:0001083)1.62317658
133Supernumerary bones of the axial skeleton (HP:0009144)1.61994591
134Overgrowth (HP:0001548)1.60383886
135Severe combined immunodeficiency (HP:0004430)1.60269891
136Increased connective tissue (HP:0009025)1.58507415
137Osteolytic defects of the hand bones (HP:0009699)1.58159377
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.58159377
139Milia (HP:0001056)1.58138847
140Cervical subluxation (HP:0003308)1.57897277
141Recurrent viral infections (HP:0004429)1.56112166
142Recurrent fungal infections (HP:0002841)1.55498783
143Joint laxity (HP:0001388)1.55255875
144Abnormality of the phalanges of the hallux (HP:0010057)1.54938385
145Abnormal number of incisors (HP:0011064)1.53587376
146Limited elbow extension (HP:0001377)1.53412382
147Proximal placement of thumb (HP:0009623)1.53330165
148Broad thumb (HP:0011304)1.53077456
149Spontaneous hematomas (HP:0007420)1.52865915
150Radial bowing (HP:0002986)1.52608936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.10168577
2MAP4K13.16277188
3CDK122.88206591
4NLK2.74089140
5TTN2.48032521
6TRIB32.44187960
7KDR2.37482656
8TYRO32.18067746
9MAPK152.07537376
10TXK2.06064079
11EPHB21.97360312
12ERN11.96524904
13CDC42BPA1.96451492
14STK101.92594253
15PKN21.79069590
16ZAP701.75491849
17JAK31.71690857
18EEF2K1.71453632
19FGFR41.65669503
20CLK11.65453425
21PDGFRA1.51663624
22TGFBR21.48673560
23TGFBR11.47654898
24EPHB11.44824685
25EPHA31.42220694
26PTK61.36605391
27LRRK21.32145324
28PRKD21.29090082
29CSK1.28645632
30DMPK1.28446595
31MKNK21.28249168
32ITK1.24908638
33IKBKE1.24136200
34RPS6KA21.22727194
35BLK1.19579294
36CHUK1.18188435
37MELK1.17172905
38RPS6KA61.16829167
39SIK11.16089260
40BTK1.15629149
41TYK21.13100189
42PAK21.11634795
43BRD41.11057639
44CDK81.10521652
45TBK11.09110735
46MAP3K141.09050302
47FGFR31.08970225
48LATS11.05744158
49GRK61.05485878
50CDK41.05051401
51IRAK31.03375853
52HCK1.03364432
53SIK20.98415652
54TIE10.98093930
55MTOR0.97588078
56RPS6KA40.96960317
57KIT0.96326666
58MKNK10.96107091
59RPS6KL10.95045473
60RPS6KC10.95045473
61LCK0.95036743
62ICK0.93440195
63MAPK70.92600844
64SMG10.89858794
65PDGFRB0.88833310
66TESK20.87009494
67IKBKB0.85441735
68PRPF4B0.85133319
69NME20.84110727
70ADRBK20.83410045
71JAK10.83181160
72PAK40.82263213
73STK30.81113299
74RIPK10.80694754
75BMX0.80480392
76NEK20.79381770
77CDK90.77790166
78PIM10.77708387
79FGFR10.77493793
80CDK60.75479286
81STK40.73108822
82FLT30.71619612
83RPS6KB20.69284013
84CDK70.68914564
85CAMK1G0.68799882
86MARK30.68054909
87HIPK20.67727850
88NTRK20.66868804
89PTK20.64698212
90DDR20.64108763
91TLK10.63880692
92PRKCH0.63086733
93DYRK20.62619988
94TEC0.62469035
95IRAK40.59387806
96TRPM70.59135875
97SIK30.58953431
98FGFR20.58219151
99FRK0.57876560
100ILK0.57788270
101WNK10.57242339
102BMPR1B0.55493085
103MAP2K20.54958957
104MAPK10.54890415
105MAP3K70.53308441
106MAP2K30.52485338
107NTRK10.50646719
108CAMK1D0.50478341
109IRAK10.50443644
110PTK2B0.50191143
111INSR0.49434519
112PNCK0.48367407
113CSF1R0.48094421
114MYLK0.47063381
115DYRK1B0.46816302
116MARK20.46647886
117SYK0.45857072
118STK240.44949868
119NUAK10.44478179
120TESK10.43630009
121MAPK80.43561539
122STK110.43159589
123LATS20.43157736
124ADRBK10.42432583
125CSNK1A1L0.42110201
126MAP3K80.41888212
127LYN0.41730551
128CDC70.40588911
129AKT10.40230044
130ROCK10.40201215
131PRKD10.40167175
132CDK30.38941951
133EIF2AK30.38855595
134RPS6KA10.38496132
135INSRR0.37456585
136PKN10.36982519
137PRKAA10.35773847
138RET0.35760627
139CAMK40.35170354
140MET0.35020508
141MARK10.31375469
142NEK90.29400995
143MAPK30.29257808
144GSK3B0.28194932
145GRK10.27958587
146PDPK10.27067225

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.68351077
2Viral myocarditis_Homo sapiens_hsa054161.98451590
3Basal cell carcinoma_Homo sapiens_hsa052171.94156321
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.90510358
5Adherens junction_Homo sapiens_hsa045201.76721067
6Small cell lung cancer_Homo sapiens_hsa052221.72698742
7T cell receptor signaling pathway_Homo sapiens_hsa046601.72358312
8ECM-receptor interaction_Homo sapiens_hsa045121.70128328
9Leishmaniasis_Homo sapiens_hsa051401.70097005
10Notch signaling pathway_Homo sapiens_hsa043301.69343838
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64611009
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.59893388
13Measles_Homo sapiens_hsa051621.58668806
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.53506717
15Dorso-ventral axis formation_Homo sapiens_hsa043201.53336041
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49612194
17Focal adhesion_Homo sapiens_hsa045101.49100702
18Toxoplasmosis_Homo sapiens_hsa051451.48293186
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46981493
20Chronic myeloid leukemia_Homo sapiens_hsa052201.45804025
21B cell receptor signaling pathway_Homo sapiens_hsa046621.43022586
22Hematopoietic cell lineage_Homo sapiens_hsa046401.42741494
23MicroRNAs in cancer_Homo sapiens_hsa052061.41609774
24Herpes simplex infection_Homo sapiens_hsa051681.40603519
25HTLV-I infection_Homo sapiens_hsa051661.39705003
26Osteoclast differentiation_Homo sapiens_hsa043801.39607904
27Proteoglycans in cancer_Homo sapiens_hsa052051.36546681
28Malaria_Homo sapiens_hsa051441.29359190
29Acute myeloid leukemia_Homo sapiens_hsa052211.29206972
30Colorectal cancer_Homo sapiens_hsa052101.27709259
31Antigen processing and presentation_Homo sapiens_hsa046121.25650666
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24939625
33Shigellosis_Homo sapiens_hsa051311.24288484
34Hippo signaling pathway_Homo sapiens_hsa043901.24086602
35TNF signaling pathway_Homo sapiens_hsa046681.16737980
36Pathways in cancer_Homo sapiens_hsa052001.16486648
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16380605
38Hedgehog signaling pathway_Homo sapiens_hsa043401.16220782
39MAPK signaling pathway_Homo sapiens_hsa040101.15794807
40Amoebiasis_Homo sapiens_hsa051461.14966994
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14424520
42TGF-beta signaling pathway_Homo sapiens_hsa043501.14231359
43Hepatitis B_Homo sapiens_hsa051611.14106442
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.13648998
45Melanoma_Homo sapiens_hsa052181.13025500
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12184538
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12125555
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11921794
49Spliceosome_Homo sapiens_hsa030401.11832910
50p53 signaling pathway_Homo sapiens_hsa041151.11788548
51Prostate cancer_Homo sapiens_hsa052151.10621853
52Allograft rejection_Homo sapiens_hsa053301.10259106
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.09947789
54Thyroid cancer_Homo sapiens_hsa052161.08415133
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05654148
56Prolactin signaling pathway_Homo sapiens_hsa049171.04586531
57Pancreatic cancer_Homo sapiens_hsa052121.04209087
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04121964
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03401883
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02905104
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01202662
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99482573
63Platelet activation_Homo sapiens_hsa046110.99459367
64Apoptosis_Homo sapiens_hsa042100.99040363
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.97855283
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97297504
67Influenza A_Homo sapiens_hsa051640.97161370
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96085588
69Salmonella infection_Homo sapiens_hsa051320.96009742
70ErbB signaling pathway_Homo sapiens_hsa040120.95955858
71Wnt signaling pathway_Homo sapiens_hsa043100.95838143
72Graft-versus-host disease_Homo sapiens_hsa053320.93805973
73Cell cycle_Homo sapiens_hsa041100.93383561
74Endometrial cancer_Homo sapiens_hsa052130.92525011
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91620191
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91545667
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91043093
78Choline metabolism in cancer_Homo sapiens_hsa052310.90601328
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89442890
80Lysine degradation_Homo sapiens_hsa003100.88453746
81Dilated cardiomyopathy_Homo sapiens_hsa054140.87732123
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87187083
83Estrogen signaling pathway_Homo sapiens_hsa049150.86840266
84Viral carcinogenesis_Homo sapiens_hsa052030.86333619
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85895254
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85766808
87Chemokine signaling pathway_Homo sapiens_hsa040620.84550985
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83191709
89Asthma_Homo sapiens_hsa053100.83081856
90Ras signaling pathway_Homo sapiens_hsa040140.83041496
91Non-small cell lung cancer_Homo sapiens_hsa052230.82145607
92Melanogenesis_Homo sapiens_hsa049160.82120930
93Ribosome_Homo sapiens_hsa030100.81018393
94Protein digestion and absorption_Homo sapiens_hsa049740.80850065
95Glioma_Homo sapiens_hsa052140.80537299
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79721343
97Cholinergic synapse_Homo sapiens_hsa047250.79343250
98DNA replication_Homo sapiens_hsa030300.77945632
99Rap1 signaling pathway_Homo sapiens_hsa040150.77537940
100Base excision repair_Homo sapiens_hsa034100.77306639
101Selenocompound metabolism_Homo sapiens_hsa004500.75885786
102Epstein-Barr virus infection_Homo sapiens_hsa051690.74949265
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73386553
104Autoimmune thyroid disease_Homo sapiens_hsa053200.73151520
105cAMP signaling pathway_Homo sapiens_hsa040240.72613261
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.72058801
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69979027
108VEGF signaling pathway_Homo sapiens_hsa043700.69369024
109Other glycan degradation_Homo sapiens_hsa005110.68754909
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68199812
111Cocaine addiction_Homo sapiens_hsa050300.68175012
112Fanconi anemia pathway_Homo sapiens_hsa034600.67768110
113mTOR signaling pathway_Homo sapiens_hsa041500.67046460
114Axon guidance_Homo sapiens_hsa043600.66513565
115Hepatitis C_Homo sapiens_hsa051600.66290307
116mRNA surveillance pathway_Homo sapiens_hsa030150.65773957
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65755286
118Pertussis_Homo sapiens_hsa051330.65535873
119Bladder cancer_Homo sapiens_hsa052190.64254108
120Renal cell carcinoma_Homo sapiens_hsa052110.62805711
121FoxO signaling pathway_Homo sapiens_hsa040680.61806386
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61743160
123Homologous recombination_Homo sapiens_hsa034400.61419923
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59961044
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58972797
126HIF-1 signaling pathway_Homo sapiens_hsa040660.58544976
127Tight junction_Homo sapiens_hsa045300.57821540
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57778605
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.57649570
130GnRH signaling pathway_Homo sapiens_hsa049120.57395296
131Morphine addiction_Homo sapiens_hsa050320.56810416
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51990816
133Type II diabetes mellitus_Homo sapiens_hsa049300.51947135
134Oxytocin signaling pathway_Homo sapiens_hsa049210.51555770

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