PLEKHG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.89799117
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.83368405
3negative regulation of cell killing (GO:0031342)5.83368405
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.26268112
5modulation by symbiont of host immune response (GO:0052553)5.26268112
6positive regulation by symbiont of host defense response (GO:0052509)5.26268112
7modulation by symbiont of host defense response (GO:0052031)5.26268112
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26268112
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26268112
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04924872
11macrophage activation involved in immune response (GO:0002281)4.64507797
12detection of other organism (GO:0098543)4.51382599
13antigen processing and presentation of endogenous antigen (GO:0019883)4.50930563
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44643858
15negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.43778608
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.40896451
17L-phenylalanine catabolic process (GO:0006559)4.40896451
18detection of bacterium (GO:0016045)4.28276782
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21343823
20L-phenylalanine metabolic process (GO:0006558)4.21343823
21detection of external biotic stimulus (GO:0098581)3.96736937
22detection of molecule of bacterial origin (GO:0032490)3.95546810
23regulation of interferon-beta biosynthetic process (GO:0045357)3.95340742
24positive regulation of gamma-delta T cell activation (GO:0046645)3.92828314
25neutrophil activation involved in immune response (GO:0002283)3.89053746
26aromatic amino acid family catabolic process (GO:0009074)3.84410268
27leukocyte aggregation (GO:0070486)3.81241302
28leukocyte migration involved in inflammatory response (GO:0002523)3.75262663
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.73659029
30sulfur amino acid catabolic process (GO:0000098)3.72845436
31neutrophil activation (GO:0042119)3.46295495
32microglial cell activation (GO:0001774)3.44101285
33detection of biotic stimulus (GO:0009595)3.44066565
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43610510
35response to host immune response (GO:0052572)3.43610510
36regulation of gamma-delta T cell activation (GO:0046643)3.42957683
37antigen processing and presentation via MHC class Ib (GO:0002475)3.41820063
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.40527731
39response to interleukin-15 (GO:0070672)3.39384226
40regulation of B cell receptor signaling pathway (GO:0050855)3.38521368
41macrophage activation (GO:0042116)3.37450654
42indole-containing compound catabolic process (GO:0042436)3.36732204
43indolalkylamine catabolic process (GO:0046218)3.36732204
44tryptophan catabolic process (GO:0006569)3.36732204
45tryptophan metabolic process (GO:0006568)3.34166737
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32270568
47response to host (GO:0075136)3.32270568
48response to host defenses (GO:0052200)3.32270568
49cellular extravasation (GO:0045123)3.29363442
50regulation of gamma-delta T cell differentiation (GO:0045586)3.27995522
51regulation of cholesterol homeostasis (GO:2000188)3.26888706
52negative regulation of leukocyte mediated immunity (GO:0002704)3.26505067
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26145332
54cellular response to interleukin-15 (GO:0071350)3.22189679
55negative regulation of type 2 immune response (GO:0002829)3.20857664
56glyoxylate metabolic process (GO:0046487)3.18225431
57regulation of ARF protein signal transduction (GO:0032012)3.15984014
58signal complex assembly (GO:0007172)3.12352620
59cysteine metabolic process (GO:0006534)3.09830090
60kynurenine metabolic process (GO:0070189)3.09461211
61homocysteine metabolic process (GO:0050667)3.09246141
62respiratory burst (GO:0045730)3.07515062
63granulocyte activation (GO:0036230)3.05348590
64response to peptidoglycan (GO:0032494)3.04839676
65production of molecular mediator involved in inflammatory response (GO:0002532)3.04815083
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04718538
67intestinal cholesterol absorption (GO:0030299)3.01357296
68negative regulation of toll-like receptor signaling pathway (GO:0034122)3.01182165
69positive regulation of Rap GTPase activity (GO:0032854)2.99137414
70negative regulation of fibrinolysis (GO:0051918)2.98475606
71negative regulation of glycoprotein biosynthetic process (GO:0010561)2.98134301
72myelin maintenance (GO:0043217)2.97708420
73embryonic retina morphogenesis in camera-type eye (GO:0060059)2.97468699
74epithelial cell differentiation involved in prostate gland development (GO:0060742)2.97298108
75desmosome organization (GO:0002934)2.96384443
76skin morphogenesis (GO:0043589)2.96160896
77peptidyl-glutamic acid carboxylation (GO:0017187)2.93933146
78protein carboxylation (GO:0018214)2.93933146
79neutrophil mediated immunity (GO:0002446)2.88671452
80regulation of ARF GTPase activity (GO:0032312)2.88386186
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87543721
82negative regulation of T cell mediated immunity (GO:0002710)2.86774681
83aromatic amino acid family metabolic process (GO:0009072)2.85981184
84tyrosine metabolic process (GO:0006570)2.84764000
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82702131
86regulation of leukocyte degranulation (GO:0043300)2.82576395
87myeloid cell activation involved in immune response (GO:0002275)2.81805568
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81357105
89positive regulation of cellular amide metabolic process (GO:0034250)2.79710770
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79076715
91negative regulation of erythrocyte differentiation (GO:0045647)2.78462359
92regulation of regulated secretory pathway (GO:1903305)2.77496006
93complement activation, alternative pathway (GO:0006957)2.77041848
94hemidesmosome assembly (GO:0031581)2.77020008
95regulation of amyloid precursor protein catabolic process (GO:1902991)2.75182449
96apoptotic cell clearance (GO:0043277)2.73696271
97regulation of beta-amyloid formation (GO:1902003)2.71886530
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71583660
99peptidyl-tyrosine autophosphorylation (GO:0038083)2.70515391
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70129699
101drug transmembrane transport (GO:0006855)2.68425441
102regulation of bile acid biosynthetic process (GO:0070857)2.67096066
103response to muramyl dipeptide (GO:0032495)2.66074237
104regulation of cellular amide metabolic process (GO:0034248)2.65827070
105lysine metabolic process (GO:0006553)2.62313207
106lysine catabolic process (GO:0006554)2.62313207
107negative regulation of interleukin-12 production (GO:0032695)2.61198921
108purine ribonucleotide transport (GO:0015868)2.60290233
109regulation of T-helper 2 cell differentiation (GO:0045628)2.59022148
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57684415
111sterol homeostasis (GO:0055092)2.54841546
112plasma lipoprotein particle clearance (GO:0034381)2.54179494
113cholesterol homeostasis (GO:0042632)2.54162273
114regulation of mast cell degranulation (GO:0043304)2.53721336
115amino-acid betaine metabolic process (GO:0006577)2.53143234
116branching involved in mammary gland duct morphogenesis (GO:0060444)2.52751563
117response to type I interferon (GO:0034340)2.52208787
118positive regulation of T cell mediated cytotoxicity (GO:0001916)2.51475844
119bile acid metabolic process (GO:0008206)2.50795409
120urea metabolic process (GO:0019627)2.50709801
121urea cycle (GO:0000050)2.50709801
122positive thymic T cell selection (GO:0045059)2.50556846
123cell-substrate junction assembly (GO:0007044)2.50265244
124regulation of Rap GTPase activity (GO:0032317)2.50238811
125actin filament polymerization (GO:0030041)2.49825218
126regulation of fibrinolysis (GO:0051917)2.49204572
127positive regulation of regulated secretory pathway (GO:1903307)2.48736319
128activation of Rac GTPase activity (GO:0032863)2.48493424
129serine family amino acid catabolic process (GO:0009071)2.48250433
130regulation of Cdc42 GTPase activity (GO:0043088)2.48030740
131response to mercury ion (GO:0046689)2.47833203
132type I interferon signaling pathway (GO:0060337)2.47090357
133cellular response to type I interferon (GO:0071357)2.47090357
134bile acid and bile salt transport (GO:0015721)2.46979415
135negative regulation of phagocytosis (GO:0050765)2.46830754
136urate metabolic process (GO:0046415)2.46575031
137bone remodeling (GO:0046849)2.46507650
138positive regulation of receptor recycling (GO:0001921)2.46267445
139phospholipid homeostasis (GO:0055091)2.45796433
140negative regulation of innate immune response (GO:0045824)2.45777590
141indolalkylamine metabolic process (GO:0006586)2.45457324
142fibrinolysis (GO:0042730)2.45247434
143low-density lipoprotein particle clearance (GO:0034383)2.45205554
144wound healing, spreading of cells (GO:0044319)2.44749770
145alpha-linolenic acid metabolic process (GO:0036109)2.44717794
146regulation of T cell mediated cytotoxicity (GO:0001914)2.44633509
147cellular modified amino acid catabolic process (GO:0042219)2.43708279
148citrulline biosynthetic process (GO:0019240)2.43373918
149wound healing, spreading of epidermal cells (GO:0035313)2.43239137
150regulation of toll-like receptor signaling pathway (GO:0034121)2.42267203
151positive regulation of p38MAPK cascade (GO:1900745)2.41812005
152fatty acid beta-oxidation (GO:0006635)2.40917841
153cell adhesion mediated by integrin (GO:0033627)2.40749046
154acylglycerol homeostasis (GO:0055090)2.40586225
155triglyceride homeostasis (GO:0070328)2.40586225
156thymic T cell selection (GO:0045061)2.40477158
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39953055
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39949845
159phospholipid scrambling (GO:0017121)2.39918132
160regulation of water loss via skin (GO:0033561)2.38321512
161positive regulation of osteoblast proliferation (GO:0033690)2.38171126
162axon ensheathment in central nervous system (GO:0032291)2.37878754
163central nervous system myelination (GO:0022010)2.37878754
164regulation of necroptotic process (GO:0060544)2.37270783
165dendritic cell migration (GO:0036336)2.36924424
166regulation of triglyceride catabolic process (GO:0010896)2.36393235
167dendritic cell chemotaxis (GO:0002407)2.35935064
168regulation of hippo signaling (GO:0035330)2.35921183
169nitrogen cycle metabolic process (GO:0071941)2.35812256
170mannose metabolic process (GO:0006013)2.35540579
171cytoplasmic mRNA processing body assembly (GO:0033962)2.35090683
172acetyl-CoA metabolic process (GO:0006084)2.34492442
173regulation of protein activation cascade (GO:2000257)2.34129592
174coenzyme catabolic process (GO:0009109)2.33683730
175response to hepatocyte growth factor (GO:0035728)2.33328836
176cellular response to hepatocyte growth factor stimulus (GO:0035729)2.33328836
177lipoprotein metabolic process (GO:0042157)2.32626274
178fatty acid oxidation (GO:0019395)2.32572549
179bile acid biosynthetic process (GO:0006699)2.32180592
180cellular biogenic amine catabolic process (GO:0042402)2.31261600
181amine catabolic process (GO:0009310)2.31261600
182proline metabolic process (GO:0006560)2.30845638
183diterpenoid biosynthetic process (GO:0016102)2.30675797
184renal filtration (GO:0097205)2.29780733
185triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.29582736
186regulation of plasminogen activation (GO:0010755)2.29448127
187biotin metabolic process (GO:0006768)2.26520754
188lipid oxidation (GO:0034440)2.26223684
189positive regulation of lipoprotein lipase activity (GO:0051006)2.25142128
190positive regulation of triglyceride lipase activity (GO:0061365)2.25142128
191regulation of integrin activation (GO:0033623)2.25140889
192very-low-density lipoprotein particle assembly (GO:0034379)2.24933607
193regulation of complement activation (GO:0030449)2.24212141
194valine metabolic process (GO:0006573)2.24115767
195protein localization to endosome (GO:0036010)2.23098198
196protein-lipid complex assembly (GO:0065005)2.22416383
197alpha-amino acid catabolic process (GO:1901606)2.21894996
198negative regulation of lipase activity (GO:0060192)2.21390160
199fatty acid elongation (GO:0030497)2.21111357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.71321730
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.26703142
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.11840956
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.63705261
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59094229
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21478832
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71723335
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.67027800
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.55751217
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.39663865
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.30198047
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28467971
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27985048
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18281452
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.17479737
16VDR_21846776_ChIP-Seq_THP-1_Human2.17463339
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15020014
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10889072
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.10394565
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07719712
21KDM2B_26808549_Chip-Seq_DND41_Human2.05117094
22SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01999728
23* FOXO3_23340844_ChIP-Seq_DLD1_Human2.00119655
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95333803
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94804925
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94678500
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87166050
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83025223
29KDM2B_26808549_Chip-Seq_K562_Human1.82804201
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78731595
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76672709
32VDR_24763502_ChIP-Seq_THP-1_Human1.75937997
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.75502890
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73573683
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72317056
36SPI1_23127762_ChIP-Seq_K562_Human1.72092907
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70954042
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.69617658
39DROSHA_22980978_ChIP-Seq_HELA_Human1.66431835
40* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64977829
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.61949881
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59536417
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58959415
44CLOCK_20551151_ChIP-Seq_293T_Human1.58859527
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56375183
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55584666
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.54339916
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54281584
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54042778
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.53280489
51* GATA4_25053715_ChIP-Seq_YYC3_Human1.53029620
52RACK7_27058665_Chip-Seq_MCF-7_Human1.50775417
53MAF_26560356_Chip-Seq_TH1_Human1.50346279
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49943521
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49312299
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.48807664
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47785220
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.46932217
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46315965
60* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45913991
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43404023
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43258444
63RUNX_20019798_ChIP-Seq_JUKART_Human1.41470915
64* GATA1_19941827_ChIP-Seq_MEL_Mouse1.41293134
65* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40429385
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38165811
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36329588
68SCL_19346495_ChIP-Seq_HPC-7_Human1.34351785
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34310238
70MYC_22102868_ChIP-Seq_BL_Human1.34041641
71CJUN_26792858_Chip-Seq_BT549_Human1.33939636
72SOX2_20726797_ChIP-Seq_SW620_Human1.33169838
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.31139579
74UTX_26944678_Chip-Seq_JUKART_Human1.30515667
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29825602
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29555540
77* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29371573
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28665229
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28658632
80SMC4_20622854_ChIP-Seq_HELA_Human1.27054334
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26985052
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26155437
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24909177
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24497744
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24280186
86* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23532747
87* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23070011
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22012618
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22000837
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21489416
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20378163
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20378163
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19423357
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19035828
95MAF_26560356_Chip-Seq_TH2_Human1.17700109
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.16361193
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15714641
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.15151582
99* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14476657
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14153932
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14067800
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13382871
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.13365862
104TP63_22573176_ChIP-Seq_HFKS_Human1.12116430
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12038129
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11047914
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10519216
108P68_20966046_ChIP-Seq_HELA_Human1.09554292
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09503541
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07461229
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06070916
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05695485
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04197207
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03645438
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.03370119
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.03370119
117* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02681172
118BP1_19119308_ChIP-ChIP_Hs578T_Human1.01988337
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01839825
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.01703316
121CREB1_26743006_Chip-Seq_LNCaP_Human1.00466923
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00451779
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.99720117
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99640880
125BCOR_27268052_Chip-Seq_Bcells_Human0.99157779
126LXR_22292898_ChIP-Seq_THP-1_Human0.98932958
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97740317
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97514315
129IRF8_27001747_Chip-Seq_BMDM_Mouse0.97474364
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.97380784
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97243582
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96903693
133ATF3_27146783_Chip-Seq_COLON_Human0.96571334
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95226147
135GATA1_19941826_ChIP-Seq_K562_Human0.94155222
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.93810362
137* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92976580
138VDR_24787735_ChIP-Seq_THP-1_Human0.92876558
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90550487
140* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90496855
141OCT4_19829295_ChIP-Seq_ESCs_Human0.89394401
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89023466
143* SPI1_23547873_ChIP-Seq_NB4_Human0.88861083
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88842712
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88465007
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88099024
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.87290117
148* TP63_23658742_ChIP-Seq_EP156T_Human0.86864174
149GATA2_19941826_ChIP-Seq_K562_Human0.86068883
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85334869
151KLF5_25053715_ChIP-Seq_YYC3_Human0.85271880
152KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84190986
153KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84190986
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84190986
155CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83782546
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83682455
157KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83388866
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81908233
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81908233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.06404223
2MP0005360_urolithiasis3.74647773
3MP0002139_abnormal_hepatobiliary_system3.51898601
4MP0005365_abnormal_bile_salt3.47145898
5MP0003436_decreased_susceptibility_to3.33444378
6MP0008438_abnormal_cutaneous_collagen3.00053764
7MP0008260_abnormal_autophagy2.93873086
8MP0005085_abnormal_gallbladder_physiolo2.87180444
9MP0003252_abnormal_bile_duct2.72789530
10MP0003303_peritoneal_inflammation2.72333063
11MP0003705_abnormal_hypodermis_morpholog2.43373022
12MP0003878_abnormal_ear_physiology2.18941089
13MP0005377_hearing/vestibular/ear_phenot2.18941089
14MP0002419_abnormal_innate_immunity2.18702143
15MP0009840_abnormal_foam_cell2.17041241
16MP0004264_abnormal_extraembryonic_tissu2.16058260
17MP0005275_abnormal_skin_tensile2.14605823
18MP0003195_calcinosis2.07494739
19MP0003566_abnormal_cell_adhesion2.00008498
20MP0010234_abnormal_vibrissa_follicle1.99829865
21MP0005025_abnormal_response_to1.94326926
22MP0001851_eye_inflammation1.91485456
23MP0003183_abnormal_peptide_metabolism1.86079152
24MP0004019_abnormal_vitamin_homeostasis1.84598141
25MP0002060_abnormal_skin_morphology1.83349099
26MP0005409_darkened_coat_color1.81581041
27MP0005451_abnormal_body_composition1.77984074
28MP0005332_abnormal_amino_acid1.77419479
29MP0003763_abnormal_thymus_physiology1.76985271
30MP0003453_abnormal_keratinocyte_physiol1.76641792
31MP0001533_abnormal_skeleton_physiology1.74747059
32MP0001666_abnormal_nutrient_absorption1.72861067
33MP0010678_abnormal_skin_adnexa1.72065738
34MP0001800_abnormal_humoral_immune1.69592252
35MP0008875_abnormal_xenobiotic_pharmacok1.67820275
36MP0003806_abnormal_nucleotide_metabolis1.66758190
37MP0000579_abnormal_nail_morphology1.63767215
38MP0005257_abnormal_intraocular_pressure1.62556550
39MP0005058_abnormal_lysosome_morphology1.61714659
40MP0003329_amyloid_beta_deposits1.59158210
41MP0006082_CNS_inflammation1.56314964
42MP0003191_abnormal_cellular_cholesterol1.56080120
43MP0000685_abnormal_immune_system1.56071414
44MP0001819_abnormal_immune_cell1.56047252
45MP0002420_abnormal_adaptive_immunity1.55682508
46MP0004858_abnormal_nervous_system1.55612301
47MP0005670_abnormal_white_adipose1.55267874
48MP0002796_impaired_skin_barrier1.53270313
49MP0000383_abnormal_hair_follicle1.53184657
50MP0003950_abnormal_plasma_membrane1.50699311
51MP0005000_abnormal_immune_tolerance1.50487648
52MP0002723_abnormal_immune_serum1.49891811
53MP0001835_abnormal_antigen_presentation1.49126245
54MP0005076_abnormal_cell_differentiation1.47545397
55MP0002396_abnormal_hematopoietic_system1.46543705
56MP0003828_pulmonary_edema1.46519230
57MP0004272_abnormal_basement_membrane1.42027117
58MP0003866_abnormal_defecation1.40968422
59MP0002877_abnormal_melanocyte_morpholog1.40839756
60MP0009643_abnormal_urine_homeostasis1.40839341
61MP0004185_abnormal_adipocyte_glucose1.40714401
62MP0003300_gastrointestinal_ulcer1.37944303
63MP0000566_synostosis1.36675887
64MP0002452_abnormal_antigen_presenting1.36600816
65MP0001790_abnormal_immune_system1.36383581
66MP0005387_immune_system_phenotype1.36383581
67MP0000920_abnormal_myelination1.36280879
68MP0005023_abnormal_wound_healing1.34465568
69MP0003045_fibrosis1.34363474
70MP0010329_abnormal_lipoprotein_level1.33140530
71MP0000462_abnormal_digestive_system1.32492880
72MP0005171_absent_coat_pigmentation1.31132208
73MP0002098_abnormal_vibrissa_morphology1.30430200
74MP0005408_hypopigmentation1.29167031
75MP0002132_abnormal_respiratory_system1.28961322
76MP0000858_altered_metastatic_potential1.26356384
77MP0004130_abnormal_muscle_cell1.25902378
78MP0002118_abnormal_lipid_homeostasis1.24514496
79MP0000609_abnormal_liver_physiology1.23366524
80MP0009785_altered_susceptibility_to1.23004670
81MP0002138_abnormal_hepatobiliary_system1.21561227
82MP0005220_abnormal_exocrine_pancreas1.19678455
83MP0001849_ear_inflammation1.19391576
84MP0010155_abnormal_intestine_physiology1.19274466
85MP0002254_reproductive_system_inflammat1.17899244
86MP0002168_other_aberrant_phenotype1.15588495
87MP0004883_abnormal_blood_vessel1.13898065
88MP0004510_myositis1.13559969
89MP0002405_respiratory_system_inflammati1.11985099
90MP0002928_abnormal_bile_duct1.11166701
91MP0010030_abnormal_orbit_morphology1.09358019
92MP0003075_altered_response_to1.08807997
93MP0000377_abnormal_hair_follicle1.07989173
94MP0001958_emphysema1.07983646
95MP0005666_abnormal_adipose_tissue1.07948485
96MP0002277_abnormal_respiratory_mucosa1.07638647
97MP0005075_abnormal_melanosome_morpholog1.07227682
98MP0000716_abnormal_immune_system1.05960494
99MP0005464_abnormal_platelet_physiology1.04846242
100MP0005671_abnormal_response_to1.03281444
101MP0005501_abnormal_skin_physiology1.03230695
102MP0004947_skin_inflammation1.01787070
103MP0004043_abnormal_pH_regulation1.00549089
104MP0000470_abnormal_stomach_morphology0.99750849
105MP0003690_abnormal_glial_cell0.98889935
106MP0001216_abnormal_epidermal_layer0.98473342
107MP0001243_abnormal_dermal_layer0.96604017
108MP0003868_abnormal_feces_composition0.96570411
109MP0005083_abnormal_biliary_tract0.96079562
110MP0000762_abnormal_tongue_morphology0.95601656
111MP0002398_abnormal_bone_marrow0.95574323
112MP0000467_abnormal_esophagus_morphology0.93190591
113MP0001845_abnormal_inflammatory_respons0.92922460
114MP0002133_abnormal_respiratory_system0.92054854
115MP0005388_respiratory_system_phenotype0.92054854
116MP0005375_adipose_tissue_phenotype0.89427965
117MP0005319_abnormal_enzyme/_coenzyme0.87532649
118MP0005164_abnormal_response_to0.87271144
119MP0005166_decreased_susceptibility_to0.87109176
120MP0004381_abnormal_hair_follicle0.87068775
121MP0000703_abnormal_thymus_morphology0.87031770
122MP0000465_gastrointestinal_hemorrhage0.86948989
123MP0005248_abnormal_Harderian_gland0.86886046
124MP0001346_abnormal_lacrimal_gland0.86809077
125MP0010352_gastrointestinal_tract_polyps0.86008450
126MP0002136_abnormal_kidney_physiology0.85138964
127MP0001756_abnormal_urination0.84632035
128MP0000015_abnormal_ear_pigmentation0.83708255
129MP0002089_abnormal_postnatal_growth/wei0.83142201
130MP0009384_cardiac_valve_regurgitation0.81918308
131MP0002896_abnormal_bone_mineralization0.81803020
132MP0005310_abnormal_salivary_gland0.80459176
133MP0003279_aneurysm0.79927563
134MP0000613_abnormal_salivary_gland0.79069147
135MP0003879_abnormal_hair_cell0.78666587
136MP0008874_decreased_physiological_sensi0.78631281
137MP0005508_abnormal_skeleton_morphology0.78233771
138MP0009278_abnormal_bone_marrow0.76529200
139MP0003091_abnormal_cell_migration0.76168095
140MP0000598_abnormal_liver_morphology0.74844929
141MP0000003_abnormal_adipose_tissue0.74574686
142MP0002332_abnormal_exercise_endurance0.74149973
143MP0000733_abnormal_muscle_development0.72663275
144MP0000427_abnormal_hair_cycle0.72552886
145MP0000678_abnormal_parathyroid_gland0.72336227
146MP0002295_abnormal_pulmonary_circulatio0.72224147
147MP0002722_abnormal_immune_system0.71765500
148MP0002429_abnormal_blood_cell0.71373596
149MP0005395_other_phenotype0.71200008
150MP0002998_abnormal_bone_remodeling0.67700292
151MP0009333_abnormal_splenocyte_physiolog0.67119917
152MP0009931_abnormal_skin_appearance0.65102741
153MP0006054_spinal_hemorrhage0.64414311
154MP0003172_abnormal_lysosome_physiology0.63998407
155MP0010771_integument_phenotype0.62601364
156MP0002697_abnormal_eye_size0.62262206
157MP0000537_abnormal_urethra_morphology0.62049584
158MP0001881_abnormal_mammary_gland0.60959189
159MP0000516_abnormal_urinary_system0.60716308
160MP0005367_renal/urinary_system_phenotyp0.60716308
161MP0000627_abnormal_mammary_gland0.59978709
162MP0000767_abnormal_smooth_muscle0.59849706
163MP0002092_abnormal_eye_morphology0.58865425
164MP0004885_abnormal_endolymph0.58660586

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.73915178
2Recurrent bacterial skin infections (HP:0005406)4.46676155
3Myositis (HP:0100614)4.38734537
4Orchitis (HP:0100796)4.31112885
5Recurrent abscess formation (HP:0002722)4.28998288
6Intrahepatic cholestasis (HP:0001406)3.79228552
7Abnormality of macrophages (HP:0004311)3.78198670
8Retrobulbar optic neuritis (HP:0100654)3.77098762
9Optic neuritis (HP:0100653)3.77098762
10Premature rupture of membranes (HP:0001788)3.65578778
11Increased IgE level (HP:0003212)3.60865108
12Recurrent gram-negative bacterial infections (HP:0005420)3.59577382
13Gastrointestinal infarctions (HP:0005244)3.42975255
14Gingivitis (HP:0000230)3.42024706
15Deep venous thrombosis (HP:0002625)3.39980131
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.37782395
17Xanthomatosis (HP:0000991)3.21175708
18Thick nail (HP:0001805)3.16542330
19Stomatitis (HP:0010280)3.15731054
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.14162887
21Abnormality of nail color (HP:0100643)3.03399248
22Keratoconjunctivitis sicca (HP:0001097)3.00511902
23Hypochromic microcytic anemia (HP:0004840)2.98017793
24Turricephaly (HP:0000262)2.94021072
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92535738
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86743511
27Atrophic scars (HP:0001075)2.84624973
28Hypochromic anemia (HP:0001931)2.83375629
29Ulnar bowing (HP:0003031)2.81848079
30Myocardial infarction (HP:0001658)2.80147307
31Alopecia of scalp (HP:0002293)2.78893206
32Hydroxyprolinuria (HP:0003080)2.76388403
33Abnormality of proline metabolism (HP:0010907)2.76388403
34Elevated erythrocyte sedimentation rate (HP:0003565)2.75282927
35Malnutrition (HP:0004395)2.74272032
36Vascular calcification (HP:0004934)2.73770862
37Keratoconjunctivitis (HP:0001096)2.72657586
38Parakeratosis (HP:0001036)2.71362436
39Cardiovascular calcification (HP:0011915)2.67393983
40Plantar hyperkeratosis (HP:0007556)2.67231934
41Focal segmental glomerulosclerosis (HP:0000097)2.59336963
42Subacute progressive viral hepatitis (HP:0006572)2.56834758
43Joint hemorrhage (HP:0005261)2.55967405
44Amyloidosis (HP:0011034)2.55630672
45Axonal loss (HP:0003447)2.54491587
46Obstructive sleep apnea (HP:0002870)2.53689452
47Right ventricular cardiomyopathy (HP:0011663)2.53524344
48Recurrent skin infections (HP:0001581)2.51508827
49Abnormality of the salivary glands (HP:0010286)2.46839402
50Hypoglycemic coma (HP:0001325)2.44159108
51Conjugated hyperbilirubinemia (HP:0002908)2.43797458
52Urticaria (HP:0001025)2.43092032
53Broad face (HP:0000283)2.41295503
54Mediastinal lymphadenopathy (HP:0100721)2.39376867
55Cheilitis (HP:0100825)2.38092823
56Episodic fever (HP:0001954)2.36995006
57Recurrent fungal infections (HP:0002841)2.34750703
58Abnormal enzyme/coenzyme activity (HP:0012379)2.34491858
59Cellulitis (HP:0100658)2.30486465
60Complement deficiency (HP:0004431)2.30131397
61Metabolic alkalosis (HP:0200114)2.28949229
62Hyperglycinuria (HP:0003108)2.28586603
63Slow saccadic eye movements (HP:0000514)2.25840943
64Abnormality of alkaline phosphatase activity (HP:0004379)2.25528634
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.24572244
66Metaphyseal cupping (HP:0003021)2.23620026
67Spontaneous hematomas (HP:0007420)2.23484323
68Gingival bleeding (HP:0000225)2.23360619
69Prolonged bleeding time (HP:0003010)2.22834797
70Abnormality of glycine metabolism (HP:0010895)2.22789356
71Abnormality of serine family amino acid metabolism (HP:0010894)2.22789356
72Glomerulosclerosis (HP:0000096)2.22735771
73Segmental peripheral demyelination/remyelination (HP:0003481)2.21274451
74Abnormality of chloride homeostasis (HP:0011422)2.19605757
75Peritonitis (HP:0002586)2.18710206
76Obstructive lung disease (HP:0006536)2.17517725
77Chronic obstructive pulmonary disease (HP:0006510)2.17517725
78Nail dystrophy (HP:0008404)2.17493315
79Palmoplantar hyperkeratosis (HP:0000972)2.17289801
80Abnormality of purine metabolism (HP:0004352)2.16910089
81Hypokalemic alkalosis (HP:0001949)2.15775727
82Fat malabsorption (HP:0002630)2.15309415
83Inflammation of the large intestine (HP:0002037)2.12945379
84Abnormality of polysaccharide metabolism (HP:0011012)2.12498962
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12498962
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12498962
87Abnormality of the common coagulation pathway (HP:0010990)2.12221425
88Epidermoid cyst (HP:0200040)2.11833374
89Peripheral demyelination (HP:0011096)2.11506643
90Abnormal blistering of the skin (HP:0008066)2.11437824
91Hypoglycemic seizures (HP:0002173)2.10681416
92Difficulty running (HP:0009046)2.10548006
93Prolonged partial thromboplastin time (HP:0003645)2.10453592
94Mucopolysacchariduria (HP:0008155)2.10323831
95Urinary glycosaminoglycan excretion (HP:0003541)2.10323831
96Gastrointestinal inflammation (HP:0004386)2.09601732
97Cerebral aneurysm (HP:0004944)2.09465716
98Hyperactive renin-angiotensin system (HP:0000841)2.09143602
99Fragile nails (HP:0001808)2.09126366
100Gout (HP:0001997)2.09036647
101Premature skin wrinkling (HP:0100678)2.08528589
102Meningitis (HP:0001287)2.07916565
103Neurofibrillary tangles (HP:0002185)2.06683486
104Elevated alkaline phosphatase (HP:0003155)2.06429526
105Hypoplasia of dental enamel (HP:0006297)2.06032135
106Hyperglycemia (HP:0003074)2.04336247
107Chest pain (HP:0100749)2.03729748
108Ketosis (HP:0001946)2.03164078
109Abnormality of the intrinsic pathway (HP:0010989)2.02942291
110Symptomatic seizures (HP:0011145)2.02362650
111Abnormality of the fingertips (HP:0001211)2.02341388
112Alkalosis (HP:0001948)2.01903674
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00334803
114Aortic dissection (HP:0002647)1.98947864
115Abnormality of nucleobase metabolism (HP:0010932)1.98780837
116Widely patent fontanelles and sutures (HP:0004492)1.98639009
117Polygenic inheritance (HP:0010982)1.98060839
118Abnormality of fatty-acid metabolism (HP:0004359)1.97440251
119Rickets (HP:0002748)1.97376950
120Hyperlipoproteinemia (HP:0010980)1.97162280
121Bronchomalacia (HP:0002780)1.97086893
122Mitral stenosis (HP:0001718)1.94841998
123Shallow orbits (HP:0000586)1.93583177
124Palmar hyperkeratosis (HP:0010765)1.93095532
125Generalized aminoaciduria (HP:0002909)1.92809057
126Cerebral inclusion bodies (HP:0100314)1.92654857
127Supranuclear gaze palsy (HP:0000605)1.91431276
128Premature loss of primary teeth (HP:0006323)1.91113213
129Abnormal vertebral ossification (HP:0100569)1.90630000
130Encephalitis (HP:0002383)1.90571791
131Dysostosis multiplex (HP:0000943)1.90494794
132Hypomagnesemia (HP:0002917)1.89163792
133Systemic lupus erythematosus (HP:0002725)1.89076624
134Proximal tubulopathy (HP:0000114)1.88405756
135Hemorrhage of the eye (HP:0011885)1.88312634
136Abnormality of complement system (HP:0005339)1.87817894
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.87417369
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.87188024
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86345576
140Hyperinsulinemic hypoglycemia (HP:0000825)1.86202556
141Tibial bowing (HP:0002982)1.85683424
142Esophageal varix (HP:0002040)1.85363243
143Abnormality of incisor morphology (HP:0011063)1.85215509
144Anorexia (HP:0002039)1.85083426
145Increased circulating renin level (HP:0000848)1.84432168
146Pulmonary embolism (HP:0002204)1.83805597
147Menorrhagia (HP:0000132)1.83074001
148Postural instability (HP:0002172)1.82518238
149Osteolytic defects of the hand bones (HP:0009699)1.81504378
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.81504378
151Coronal craniosynostosis (HP:0004440)1.81386089
152Vasculitis (HP:0002633)1.81193056
153Acne (HP:0001061)1.80577806
154Cervical subluxation (HP:0003308)1.80314683
155Ankle clonus (HP:0011448)1.78648811
156Arterial thrombosis (HP:0004420)1.78399470
157Protrusio acetabuli (HP:0003179)1.78308018
158Milia (HP:0001056)1.77994728
159Abnormal platelet volume (HP:0011876)1.77400466
160Onion bulb formation (HP:0003383)1.77254442
161Ketoacidosis (HP:0001993)1.77152648
162Hemoptysis (HP:0002105)1.75699670
163Skin ulcer (HP:0200042)1.75545350
164Vacuolated lymphocytes (HP:0001922)1.75416664
165Onycholysis (HP:0001806)1.74329542
166Ankyloglossia (HP:0010296)1.73686626
167Pustule (HP:0200039)1.73602585
168Abdominal distention (HP:0003270)1.73587901
169Bowed forearm bones (HP:0003956)1.73585897
170Bowing of the arm (HP:0006488)1.73585897
171Hypoalphalipoproteinemia (HP:0003233)1.72349644
172Fragile skin (HP:0001030)1.72252316
173Hyperglycinemia (HP:0002154)1.71483410
174Tetany (HP:0001281)1.71100949
175Pancreatic islet-cell hyperplasia (HP:0004510)1.70737757
176Germ cell neoplasia (HP:0100728)1.70691834
177Hypoplasia of the iris (HP:0007676)1.69745763
178Thin bony cortex (HP:0002753)1.69582547
179Muscle fiber splitting (HP:0003555)1.67842185
180Sepsis (HP:0100806)1.67507122
181Interstitial pulmonary disease (HP:0006530)1.66549209
182Lip pit (HP:0100267)1.66433060
183Pili torti (HP:0003777)1.64814429
184Periodontitis (HP:0000704)1.64741335
185Increased connective tissue (HP:0009025)1.62214117
186Amelogenesis imperfecta (HP:0000705)1.61508573
187Diplopia (HP:0000651)1.60756951
188Abnormality of binocular vision (HP:0011514)1.60756951
189Micronodular cirrhosis (HP:0001413)1.60519530
190Ventricular tachycardia (HP:0004756)1.60386712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.28297170
2RIPK43.33909127
3LATS13.31078219
4EPHB12.91781124
5TAOK32.53245416
6MAPK152.48580292
7ERN12.32153054
8STK392.20979446
9INSRR2.18909025
10TRPM72.18890626
11MET2.12437053
12OXSR12.09195632
13MAP2K32.07339432
14MAP4K11.99964927
15SIK11.94166624
16TAOK11.91653019
17STK38L1.86140195
18WNK41.81965545
19GRK61.71561768
20BMX1.70766255
21KSR21.70536445
22TRIB31.66530673
23TYK21.64250935
24CDK121.62416103
25DDR21.59864182
26FES1.56068818
27PTK21.56012448
28TTN1.55905755
29MAP3K21.55839040
30MST1R1.55799918
31SMG11.55783915
32ZAP701.47689560
33PRPF4B1.46662112
34MAP3K11.45962185
35RIPK11.39218172
36STK31.36519329
37PKN11.36443582
38ICK1.35472891
39STK101.35130714
40MAP3K111.33951684
41STK381.33869436
42PTK61.33096359
43WNK11.30686707
44CSK1.29532353
45HCK1.26420412
46MAP3K71.20976252
47CAMK1D1.20679430
48BTK1.20368451
49MAP3K91.19997772
50SGK31.18532190
51ERBB41.18488216
52MAP3K141.17725395
53PDGFRA1.16938971
54FGFR41.14158457
55BCKDK1.10285507
56MTOR1.06302530
57STK111.04101869
58DAPK21.03816143
59YES11.02949997
60MARK30.99562696
61MAP2K20.98598480
62IRAK20.98056302
63MAP3K30.96603454
64GSK3A0.94739337
65PDPK10.94457942
66JAK30.93940973
67JAK20.93346355
68FLT30.90632257
69IRAK30.90606786
70PTK2B0.87545055
71PIK3CG0.87535624
72SGK20.87193098
73PDK10.87160357
74EPHA30.84264144
75PAK40.84215570
76CDC42BPA0.82859900
77IKBKE0.82808917
78PRKD20.82563044
79FGFR30.81780205
80RET0.81748176
81PRKAA20.80505988
82FRK0.78627534
83BRSK20.76885493
84CAMK1G0.73452964
85NEK90.72238826
86PIK3CA0.71837353
87IRAK10.71347822
88PRKD10.70781298
89LCK0.70749320
90FER0.70737495
91DYRK1B0.70510519
92RPS6KA20.70155507
93PDGFRB0.69720062
94PRKD30.69626566
95NUAK10.69306130
96PAK20.68918005
97TGFBR20.68474285
98SIK30.66296805
99MAPK110.66013429
100FYN0.64689356
101CAMKK10.64593188
102MARK20.62504450
103PRKG20.61510140
104MAP2K60.60870086
105RPS6KL10.60460635
106RPS6KC10.60460635
107MAP2K40.59912161
108KSR10.59419387
109DMPK0.58707576
110PRKCZ0.58604368
111NEK60.58513633
112CHUK0.58412166
113SYK0.57690303
114SIK20.57327476
115UHMK10.57172455
116CDK60.57089294
117HIPK20.56418838
118MST40.56326715
119MELK0.56242352
120FGFR20.54208378
121RPS6KA60.54196614
122PRKCH0.54025681
123IKBKB0.53508456
124JAK10.50996572
125NTRK30.50781583
126SGK4940.49955991
127SGK2230.49955991
128LATS20.49546602
129MAPK120.49298512
130LYN0.49296740
131WNK30.48940413
132TBK10.48819348
133LRRK20.47879363
134ABL10.47764622
135STK240.47488686
136BLK0.47223829
137ERBB20.46437418
138CAMK2D0.46325961
139MAPKAPK20.45923544
140PRKAA10.45345336
141RAF10.45167145
142MATK0.44891171
143CAMK2G0.40755491
144FGR0.40735352
145IRAK40.39013362
146MAP3K60.38552994
147AKT30.38327055
148MAPK10.37367117
149PAK30.37237594
150TNK20.36964910
151PKN20.35822554
152MAP3K130.35658977
153MAPK70.35241150
154ITK0.35238406
155PINK10.34842486
156CSF1R0.34638498
157MAPKAPK50.34601438
158RPS6KB20.34250059

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.49848033
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37431777
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.28422087
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.20501334
5Tryptophan metabolism_Homo sapiens_hsa003802.09536122
6Osteoclast differentiation_Homo sapiens_hsa043802.09211910
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08572628
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06214391
9Complement and coagulation cascades_Homo sapiens_hsa046102.04770809
10Histidine metabolism_Homo sapiens_hsa003402.01834092
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97012485
12Steroid biosynthesis_Homo sapiens_hsa001001.94557018
13Sulfur metabolism_Homo sapiens_hsa009201.90897318
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88048650
15Fatty acid degradation_Homo sapiens_hsa000711.82910565
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81927916
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80689771
18Vitamin B6 metabolism_Homo sapiens_hsa007501.74065149
19Staphylococcus aureus infection_Homo sapiens_hsa051501.73457031
20Arginine biosynthesis_Homo sapiens_hsa002201.67931858
21Fatty acid elongation_Homo sapiens_hsa000621.65958903
22Peroxisome_Homo sapiens_hsa041461.64715038
23Acute myeloid leukemia_Homo sapiens_hsa052211.61812392
24VEGF signaling pathway_Homo sapiens_hsa043701.61640797
25Fatty acid metabolism_Homo sapiens_hsa012121.57998849
26PPAR signaling pathway_Homo sapiens_hsa033201.56846882
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54361219
28Lysine degradation_Homo sapiens_hsa003101.53518593
29B cell receptor signaling pathway_Homo sapiens_hsa046621.53237696
30beta-Alanine metabolism_Homo sapiens_hsa004101.52926198
31Vitamin digestion and absorption_Homo sapiens_hsa049771.50969837
32Leishmaniasis_Homo sapiens_hsa051401.49990578
33Non-small cell lung cancer_Homo sapiens_hsa052231.43918812
34Arginine and proline metabolism_Homo sapiens_hsa003301.43490183
35Other glycan degradation_Homo sapiens_hsa005111.43467228
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42850026
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42499714
38Butanoate metabolism_Homo sapiens_hsa006501.42457435
39Folate biosynthesis_Homo sapiens_hsa007901.42450160
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39795460
41Inositol phosphate metabolism_Homo sapiens_hsa005621.35780925
42Chemokine signaling pathway_Homo sapiens_hsa040621.34295562
43Retinol metabolism_Homo sapiens_hsa008301.33174733
44T cell receptor signaling pathway_Homo sapiens_hsa046601.31328068
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29570296
46Propanoate metabolism_Homo sapiens_hsa006401.28904116
47Selenocompound metabolism_Homo sapiens_hsa004501.28284034
48ECM-receptor interaction_Homo sapiens_hsa045121.27948224
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27712263
50Endometrial cancer_Homo sapiens_hsa052131.26332724
51Tuberculosis_Homo sapiens_hsa051521.24727788
52ABC transporters_Homo sapiens_hsa020101.23492129
53GnRH signaling pathway_Homo sapiens_hsa049121.23072433
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.22999385
55Chronic myeloid leukemia_Homo sapiens_hsa052201.22924314
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.20888535
57Chemical carcinogenesis_Homo sapiens_hsa052041.20402762
58Renal cell carcinoma_Homo sapiens_hsa052111.18249204
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17224927
60Starch and sucrose metabolism_Homo sapiens_hsa005001.16963737
61Dorso-ventral axis formation_Homo sapiens_hsa043201.16842415
62ErbB signaling pathway_Homo sapiens_hsa040121.16638120
63Choline metabolism in cancer_Homo sapiens_hsa052311.15347134
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14086369
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13299266
66Endocytosis_Homo sapiens_hsa041441.12853959
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.11599215
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10490279
69Toxoplasmosis_Homo sapiens_hsa051451.10440990
70Caffeine metabolism_Homo sapiens_hsa002321.08884388
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07303568
72Linoleic acid metabolism_Homo sapiens_hsa005911.06392354
73Bile secretion_Homo sapiens_hsa049761.05933048
74Platelet activation_Homo sapiens_hsa046111.04428344
75Pancreatic cancer_Homo sapiens_hsa052121.03740998
76Lysosome_Homo sapiens_hsa041421.03514758
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01701111
78Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00460790
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.99623278
80Fat digestion and absorption_Homo sapiens_hsa049750.99537742
81Measles_Homo sapiens_hsa051620.97881897
82Long-term potentiation_Homo sapiens_hsa047200.97566622
83Estrogen signaling pathway_Homo sapiens_hsa049150.97104586
84Rap1 signaling pathway_Homo sapiens_hsa040150.96646627
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93044632
86Protein digestion and absorption_Homo sapiens_hsa049740.91776526
87Glioma_Homo sapiens_hsa052140.91691599
88Gastric acid secretion_Homo sapiens_hsa049710.90997052
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90296391
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90262891
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89896551
92mTOR signaling pathway_Homo sapiens_hsa041500.89864234
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.89700564
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89578798
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.89162243
96TNF signaling pathway_Homo sapiens_hsa046680.88885936
97FoxO signaling pathway_Homo sapiens_hsa040680.88777839
98Prolactin signaling pathway_Homo sapiens_hsa049170.88084543
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88054894
100African trypanosomiasis_Homo sapiens_hsa051430.87934031
101Glutathione metabolism_Homo sapiens_hsa004800.86959837
102Phenylalanine metabolism_Homo sapiens_hsa003600.85237240
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85103533
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84088273
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83318449
106Insulin signaling pathway_Homo sapiens_hsa049100.81805230
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81512339
108Influenza A_Homo sapiens_hsa051640.80255433
109Fatty acid biosynthesis_Homo sapiens_hsa000610.79727150
110Arachidonic acid metabolism_Homo sapiens_hsa005900.79178406
111Type II diabetes mellitus_Homo sapiens_hsa049300.78504114
112Small cell lung cancer_Homo sapiens_hsa052220.77986503
113Adherens junction_Homo sapiens_hsa045200.77682090
114Bladder cancer_Homo sapiens_hsa052190.77559008
115Thyroid cancer_Homo sapiens_hsa052160.76966015
116Tyrosine metabolism_Homo sapiens_hsa003500.74715608
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74478744
118Ether lipid metabolism_Homo sapiens_hsa005650.74145832
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.74140146
120Focal adhesion_Homo sapiens_hsa045100.72720399
121MAPK signaling pathway_Homo sapiens_hsa040100.72706659
122Glycerolipid metabolism_Homo sapiens_hsa005610.71679493
123Apoptosis_Homo sapiens_hsa042100.70868336
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70598050
125Amoebiasis_Homo sapiens_hsa051460.70162319
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.69625387
127Hepatitis B_Homo sapiens_hsa051610.69385405
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66409579
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66033743
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.65515189
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65242564
132Sphingolipid metabolism_Homo sapiens_hsa006000.65192628
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63635682
134Colorectal cancer_Homo sapiens_hsa052100.63606931
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63111210
136Ras signaling pathway_Homo sapiens_hsa040140.62968364
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.62852309
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.62299003
139Axon guidance_Homo sapiens_hsa043600.61012132
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60214307
141Tight junction_Homo sapiens_hsa045300.60035273
142Legionellosis_Homo sapiens_hsa051340.59832109
143Mineral absorption_Homo sapiens_hsa049780.59748961
144Salmonella infection_Homo sapiens_hsa051320.58742166
145Long-term depression_Homo sapiens_hsa047300.57784172
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57623524
147HIF-1 signaling pathway_Homo sapiens_hsa040660.57207528
148AMPK signaling pathway_Homo sapiens_hsa041520.56479940
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55542689
150Renin secretion_Homo sapiens_hsa049240.55464750
151Phagosome_Homo sapiens_hsa041450.54605151
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53493356
153Malaria_Homo sapiens_hsa051440.52812008
154Insulin resistance_Homo sapiens_hsa049310.52263777
155cAMP signaling pathway_Homo sapiens_hsa040240.51908440
156Pancreatic secretion_Homo sapiens_hsa049720.51305178
157Proteoglycans in cancer_Homo sapiens_hsa052050.50663124
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49106247
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48947509
160Cyanoamino acid metabolism_Homo sapiens_hsa004600.48284220
161MicroRNAs in cancer_Homo sapiens_hsa052060.48171385
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46493342
1632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45282949
164Hippo signaling pathway_Homo sapiens_hsa043900.44854932
165PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43773651
166Pentose phosphate pathway_Homo sapiens_hsa000300.43363822
167Biosynthesis of amino acids_Homo sapiens_hsa012300.42586164
168Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42515019
169Fructose and mannose metabolism_Homo sapiens_hsa000510.42193386
170Notch signaling pathway_Homo sapiens_hsa043300.41991866
171Prostate cancer_Homo sapiens_hsa052150.39283409
172Hepatitis C_Homo sapiens_hsa051600.39231969
173Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38134133
174Renin-angiotensin system_Homo sapiens_hsa046140.36068866
175Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36009125
176Pyruvate metabolism_Homo sapiens_hsa006200.35873637
177Adipocytokine signaling pathway_Homo sapiens_hsa049200.35143312
178Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35074032
179Glycerophospholipid metabolism_Homo sapiens_hsa005640.34546334
180Carbon metabolism_Homo sapiens_hsa012000.32926957

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