PLEKHG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)9.12676417
2mesenchymal cell differentiation involved in kidney development (GO:0072161)6.48235916
3mesenchymal cell differentiation involved in renal system development (GO:2001012)6.48235916
4presynaptic membrane assembly (GO:0097105)6.34570207
5mitotic sister chromatid cohesion (GO:0007064)6.29130392
6response to redox state (GO:0051775)5.79091903
7piRNA metabolic process (GO:0034587)5.60214024
8gamma-aminobutyric acid transport (GO:0015812)5.37183482
9cilium or flagellum-dependent cell motility (GO:0001539)5.36009221
10nuclear pore complex assembly (GO:0051292)5.25894115
11presynaptic membrane organization (GO:0097090)5.23887720
12DNA methylation involved in gamete generation (GO:0043046)5.18015652
13vocalization behavior (GO:0071625)4.73980650
14DNA synthesis involved in DNA repair (GO:0000731)4.66002896
15nuclear pore organization (GO:0006999)4.29848556
16mitotic chromosome condensation (GO:0007076)4.28310429
17synaptonemal complex organization (GO:0070193)4.27100032
18synaptonemal complex assembly (GO:0007130)4.20569046
19male meiosis (GO:0007140)4.14334531
20Golgi transport vesicle coating (GO:0048200)4.12203230
21COPI coating of Golgi vesicle (GO:0048205)4.12203230
22axonemal dynein complex assembly (GO:0070286)4.06439117
23postsynaptic membrane organization (GO:0001941)4.04866426
24mannose metabolic process (GO:0006013)4.02584247
25cell differentiation involved in kidney development (GO:0061005)3.93334704
26histone H3-K9 demethylation (GO:0033169)3.92052243
27startle response (GO:0001964)3.91100654
28regulation of meiosis I (GO:0060631)3.88363331
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87285814
30neuron cell-cell adhesion (GO:0007158)3.86674563
31replication fork processing (GO:0031297)3.83912741
32epithelial cell differentiation involved in kidney development (GO:0035850)3.81075353
33histone H3-K36 demethylation (GO:0070544)3.74202443
34negative regulation of cell size (GO:0045792)3.71095405
35epithelial cilium movement (GO:0003351)3.69685321
36replicative senescence (GO:0090399)3.69067781
37regulation of translational fidelity (GO:0006450)3.68039630
38DNA unwinding involved in DNA replication (GO:0006268)3.66554655
39meiotic chromosome segregation (GO:0045132)3.64650501
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61531811
41negative regulation of axon guidance (GO:1902668)3.57600122
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56495977
43kinetochore assembly (GO:0051382)3.56416564
44proline biosynthetic process (GO:0006561)3.54885121
45chromosome organization involved in meiosis (GO:0070192)3.53423696
46synapsis (GO:0007129)3.52917294
47virion assembly (GO:0019068)3.52452919
48desmosome organization (GO:0002934)3.51913572
49pore complex assembly (GO:0046931)3.51731243
50activation of Rac GTPase activity (GO:0032863)3.49432075
51RNA localization (GO:0006403)3.49350329
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42329993
53negative regulation of erythrocyte differentiation (GO:0045647)3.39962039
54sister chromatid cohesion (GO:0007062)3.39096379
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38957636
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34090747
57specification of organ identity (GO:0010092)3.33825264
58protein retention in ER lumen (GO:0006621)3.33026103
59histone H4 deacetylation (GO:0070933)3.28682725
60kinetochore organization (GO:0051383)3.28137615
61regulation of axon guidance (GO:1902667)3.27939296
62lactate metabolic process (GO:0006089)3.24352910
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.20250417
64snRNA metabolic process (GO:0016073)3.19621201
65DNA replication initiation (GO:0006270)3.15891516
66pre-miRNA processing (GO:0031054)3.14489217
67mesenchymal cell differentiation (GO:0048762)3.14313524
68interkinetic nuclear migration (GO:0022027)3.11393550
69regulation of histone H3-K27 methylation (GO:0061085)3.10725326
70apoptotic process involved in morphogenesis (GO:0060561)3.09851037
71regulation of sarcomere organization (GO:0060297)3.08830822
72DNA methylation (GO:0006306)3.04089974
73DNA alkylation (GO:0006305)3.04089974
74cell migration in hindbrain (GO:0021535)3.03934720
75meiotic nuclear division (GO:0007126)3.03817153
76regulation of respiratory system process (GO:0044065)3.02340266
77planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00419459
78cell-substrate junction assembly (GO:0007044)2.99420218
79axon extension (GO:0048675)2.98878486
80cerebellar Purkinje cell layer development (GO:0021680)2.98069273
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97616236
82cilium movement (GO:0003341)2.97426036
83focal adhesion assembly (GO:0048041)2.96944021
84cell-substrate adherens junction assembly (GO:0007045)2.96944021
85snRNA processing (GO:0016180)2.96917629
86epithelial cell-cell adhesion (GO:0090136)2.96574282
87regulation of RNA export from nucleus (GO:0046831)2.96264880
88myotube differentiation (GO:0014902)2.96118684
89regulation of skeletal muscle cell differentiation (GO:2001014)2.95443355
90positive regulation of meiosis (GO:0045836)2.95434775
91protein localization to microtubule (GO:0035372)2.95319762
92male meiosis I (GO:0007141)2.93618119
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93527403
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.91232347
95adherens junction assembly (GO:0034333)2.91137684
96membrane assembly (GO:0071709)2.91099413
97L-amino acid import (GO:0043092)2.90914140
98regulation of nucleobase-containing compound transport (GO:0032239)2.89675044
99response to parathyroid hormone (GO:0071107)2.88108659
100hemidesmosome assembly (GO:0031581)2.87798230
101regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86396876
102semaphorin-plexin signaling pathway (GO:0071526)2.85338857
103acrosome reaction (GO:0007340)2.85067161
104positive regulation of osteoblast proliferation (GO:0033690)2.84897763
105UV protection (GO:0009650)2.83830027
106bone trabecula formation (GO:0060346)2.82850332
107positive regulation of protein sumoylation (GO:0033235)2.81267959
108histone H4-K5 acetylation (GO:0043981)2.80551212
109histone H4-K8 acetylation (GO:0043982)2.80551212
110mitotic nuclear envelope disassembly (GO:0007077)2.79787490
111sperm motility (GO:0030317)2.79490706
112protein localization to cell surface (GO:0034394)2.77087843
113histone H4-K12 acetylation (GO:0043983)2.76536598
114activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.75856814
115mitochondrion distribution (GO:0048311)2.75334661
116gene silencing by RNA (GO:0031047)2.75085315
117regulation of NFAT protein import into nucleus (GO:0051532)2.73764354
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73593355
119mRNA splice site selection (GO:0006376)2.73327721
120secondary heart field specification (GO:0003139)2.73084947
121heart field specification (GO:0003128)2.73084947
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73064967
123protein targeting to plasma membrane (GO:0072661)2.72967379
124spliceosomal tri-snRNP complex assembly (GO:0000244)2.72954650
125DNA duplex unwinding (GO:0032508)2.72567628
126positive regulation of nuclease activity (GO:0032075)2.72555681
127prepulse inhibition (GO:0060134)2.71958045
128positive regulation of meiotic cell cycle (GO:0051446)2.71671907
129synaptic transmission, glutamatergic (GO:0035249)2.70124679
130mitotic sister chromatid segregation (GO:0000070)2.69905238
131poly(A)+ mRNA export from nucleus (GO:0016973)2.69354222
132seminiferous tubule development (GO:0072520)2.68437432
133cellular response to epidermal growth factor stimulus (GO:0071364)2.68287788
134regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67863975
135regulation of glutamate receptor signaling pathway (GO:1900449)2.66685925
136regulation of ARF GTPase activity (GO:0032312)2.65590950
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.64771616
138axon extension involved in axon guidance (GO:0048846)2.64771616
139regulation of respiratory gaseous exchange (GO:0043576)2.64411580
140nuclear envelope disassembly (GO:0051081)2.63822908
141membrane disassembly (GO:0030397)2.63822908
142nuclear envelope organization (GO:0006998)2.63419361
143atrioventricular valve morphogenesis (GO:0003181)2.63111487
144DNA damage induced protein phosphorylation (GO:0006975)2.62880426
145neuromuscular junction development (GO:0007528)2.62197142
146chromosome condensation (GO:0030261)2.62087899
147regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60577079
148basement membrane organization (GO:0071711)2.58947050
149regulation of male gonad development (GO:2000018)2.58809088
150meiosis I (GO:0007127)2.58699179
151positive regulation of male gonad development (GO:2000020)2.58538205
152positive regulation of synapse assembly (GO:0051965)2.58372467
153nuclear envelope reassembly (GO:0031468)2.57874235
154mitotic nuclear envelope reassembly (GO:0007084)2.57874235
155dendrite morphogenesis (GO:0048813)2.57429585
156positive regulation of histone deacetylation (GO:0031065)2.57427236
157cardiac ventricle formation (GO:0003211)2.57070967
158heterochromatin organization (GO:0070828)2.55840526
159mitochondrial genome maintenance (GO:0000002)2.55155584
160G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55014976
161cytoplasmic microtubule organization (GO:0031122)2.54731698
162skin morphogenesis (GO:0043589)2.54432125
163sperm-egg recognition (GO:0035036)2.54079363
164fusion of sperm to egg plasma membrane (GO:0007342)2.53539599
165synaptic vesicle endocytosis (GO:0048488)2.52957082
166DNA geometric change (GO:0032392)2.52627649
167histone H3 deacetylation (GO:0070932)2.51683481
168cellular protein complex localization (GO:0034629)2.51210871
169establishment of apical/basal cell polarity (GO:0035089)2.49535105
170positive regulation of DNA-dependent DNA replication (GO:2000105)2.48886981
171histone H4-K16 acetylation (GO:0043984)2.45057071
172negative regulation of macroautophagy (GO:0016242)2.44926154
173DNA strand elongation involved in DNA replication (GO:0006271)2.44363799
174signal complex assembly (GO:0007172)2.43402597
175regulation of nuclease activity (GO:0032069)2.42687864
176DNA conformation change (GO:0071103)2.42041737
177histone lysine demethylation (GO:0070076)2.41765447
178regulation of mitotic spindle organization (GO:0060236)2.41212716
179convergent extension (GO:0060026)2.41053181
180DNA strand elongation (GO:0022616)2.40982550
181sister chromatid segregation (GO:0000819)2.39988638
182endoplasmic reticulum unfolded protein response (GO:0030968)2.39813116
183negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.39662264
184morphogenesis of embryonic epithelium (GO:0016331)2.38973005
185endothelial cell chemotaxis (GO:0035767)2.38639308
186meiotic cell cycle process (GO:1903046)2.36798832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.36366132
2EZH2_22144423_ChIP-Seq_EOC_Human5.23795265
3E2F7_22180533_ChIP-Seq_HELA_Human5.05775331
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.14579928
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.80187578
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.19277320
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.60294745
8ZNF263_19887448_ChIP-Seq_K562_Human2.55834527
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.44971927
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39140355
11GBX2_23144817_ChIP-Seq_PC3_Human2.34033324
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33691820
13MYC_22102868_ChIP-Seq_BL_Human2.25290111
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22758756
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.22705695
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22211507
17VDR_21846776_ChIP-Seq_THP-1_Human2.19467930
18DROSHA_22980978_ChIP-Seq_HELA_Human2.18566176
19LXR_22292898_ChIP-Seq_THP-1_Human2.18383599
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16417835
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15961685
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13205928
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11287653
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04691632
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04582710
26RACK7_27058665_Chip-Seq_MCF-7_Human2.03028704
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01043352
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00466688
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95047394
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95047394
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92576324
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.88459727
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85770194
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83804075
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.83479676
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77725008
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76913142
38* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74872101
39REST_21632747_ChIP-Seq_MESCs_Mouse1.73461001
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70729671
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70729671
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68416055
43TCF7_22412390_ChIP-Seq_EML_Mouse1.66971908
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66738727
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65542359
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63344345
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60155699
48KDM2B_26808549_Chip-Seq_DND41_Human1.58887429
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.58700086
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58427155
51TP53_16413492_ChIP-PET_HCT116_Human1.57665091
52* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57319136
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56063603
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54640311
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54624161
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54122726
57P68_20966046_ChIP-Seq_HELA_Human1.53839032
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52821318
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52641295
60ATF3_27146783_Chip-Seq_COLON_Human1.51996158
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51941128
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.51715979
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50179581
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49509675
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48985727
66TAF15_26573619_Chip-Seq_HEK293_Human1.48946220
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48919839
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.48173347
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46527515
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.46425382
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.45266762
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44197405
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42860514
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.42080190
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42026070
76* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41013787
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.40645436
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40045541
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39919177
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39846888
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39545219
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39494338
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39058007
84NCOR1_26117541_ChIP-Seq_K562_Human1.38096466
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36336412
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35956642
87* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35687007
88KDM2B_26808549_Chip-Seq_K562_Human1.35427703
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35311218
90* SMC4_20622854_ChIP-Seq_HELA_Human1.35170545
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35031840
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34622779
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32910367
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32390233
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.32053276
96TP53_22127205_ChIP-Seq_IMR90_Human1.32012515
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31663386
98RNF2_27304074_Chip-Seq_NSC_Mouse1.31540073
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.31305990
100* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30637155
101XRN2_22483619_ChIP-Seq_HELA_Human1.30429204
102* STAT3_23295773_ChIP-Seq_U87_Human1.30168717
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.29575936
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.29287050
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.28600221
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28564047
107CLOCK_20551151_ChIP-Seq_293T_Human1.28395751
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.28029888
109MAF_26560356_Chip-Seq_TH2_Human1.27683565
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27216619
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25785457
112SMAD4_21799915_ChIP-Seq_A2780_Human1.25607200
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25474381
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25179940
115TCF4_23295773_ChIP-Seq_U87_Human1.24812663
116* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24126499
117SOX9_26525672_Chip-Seq_HEART_Mouse1.23463842
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.22058991
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.21620602
120DCP1A_22483619_ChIP-Seq_HELA_Human1.21356195
121MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21175322
122ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20626605
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20334987
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19796666
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19767125
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19503497
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.19476460
128* CREB1_26743006_Chip-Seq_LNCaP_Human1.19465219
129GABP_19822575_ChIP-Seq_HepG2_Human1.18686837
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18190155
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17543689
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17268275
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.17260769
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16535049
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16245248
136* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15632034
137BCAT_22108803_ChIP-Seq_LS180_Human1.15187745
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15122603
139ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13460422
140E2F1_21310950_ChIP-Seq_MCF-7_Human1.12879538
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12732432
142KDM5A_27292631_Chip-Seq_BREAST_Human1.12608827
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.12397102
144CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11444569
145IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10977064
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10814766
147CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10572334
148SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10471449
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10054282
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09974682
151REST_18959480_ChIP-ChIP_MESCs_Mouse1.09924471
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09443927
153MAF_26560356_Chip-Seq_TH1_Human1.08969638
154UBF1/2_26484160_Chip-Seq_HMECs_Human1.07512593
155NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07410556
156* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07372190
157BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07317319
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06577843
159NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06491474
160RUNX1_27514584_Chip-Seq_MCF-7_Human1.06438420
161ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06016871
162THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04831163
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04653856
164SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04216490
165RUNX1_22412390_ChIP-Seq_EML_Mouse1.03754547
166PHF8_20622854_ChIP-Seq_HELA_Human1.03728954
167NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03639133
168ZNF274_21170338_ChIP-Seq_K562_Hela1.03138507
169* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02469833
170SMAD4_21741376_ChIP-Seq_EPCs_Human1.02131890
171GATA1_26923725_Chip-Seq_HPCs_Mouse1.01974172
172CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00301881
173MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00054441
174TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00011237
175TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99589097
176P53_22387025_ChIP-Seq_ESCs_Mouse0.99218857
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98845324
178TFEB_21752829_ChIP-Seq_HELA_Human0.98698057
179RARA_24833708_ChIP-Seq_LIVER_Mouse0.98169991
180BCOR_27268052_Chip-Seq_Bcells_Human0.98087275
181AR_25329375_ChIP-Seq_VCAP_Human0.97594770
182NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97532187
183SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96934307
184POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96311997
185EP300_21415370_ChIP-Seq_HL-1_Mouse0.96129503
186SMAD3_21741376_ChIP-Seq_HESCs_Human0.95184064
187YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94667088
188WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93286744
189TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92667425
190SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91298870
191RING1B_27294783_Chip-Seq_ESCs_Mouse0.91121553
192AR_19668381_ChIP-Seq_PC3_Human0.91087192
193TP53_18474530_ChIP-ChIP_U2OS_Human0.90870305
194EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89959549
195ER_23166858_ChIP-Seq_MCF-7_Human0.88282682
196RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87814875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous6.21163640
2MP0003705_abnormal_hypodermis_morpholog4.83675559
3MP0001986_abnormal_taste_sensitivity4.26654477
4MP0010234_abnormal_vibrissa_follicle3.27635514
5MP0002877_abnormal_melanocyte_morpholog3.27445873
6MP0005410_abnormal_fertilization2.98218425
7MP0003787_abnormal_imprinting2.71692436
8MP0008877_abnormal_DNA_methylation2.66388218
9MP0002909_abnormal_adrenal_gland2.64137325
10MP0005451_abnormal_body_composition2.54786441
11MP0005058_abnormal_lysosome_morphology2.46695450
12MP0004859_abnormal_synaptic_plasticity2.30762995
13MP0001849_ear_inflammation2.28641982
14MP0003566_abnormal_cell_adhesion2.12650492
15MP0003698_abnormal_male_reproductive2.11703549
16MP0000678_abnormal_parathyroid_gland2.04299746
17MP0001661_extended_life_span2.03145602
18MP0002060_abnormal_skin_morphology2.00426314
19MP0005623_abnormal_meninges_morphology1.96958071
20MP0008260_abnormal_autophagy1.96134713
21MP0001501_abnormal_sleep_pattern1.93403494
22MP0003880_abnormal_central_pattern1.90967305
23MP0005275_abnormal_skin_tensile1.90082218
24MP0002063_abnormal_learning/memory/cond1.89555765
25MP0010030_abnormal_orbit_morphology1.87801898
26MP0005187_abnormal_penis_morphology1.87713427
27MP0005248_abnormal_Harderian_gland1.85800051
28MP0010386_abnormal_urinary_bladder1.85438616
29MP0001188_hyperpigmentation1.80327102
30MP0003303_peritoneal_inflammation1.79344824
31MP0009745_abnormal_behavioral_response1.76886013
32MP0002210_abnormal_sex_determination1.76872032
33MP0003635_abnormal_synaptic_transmissio1.76119545
34MP0001929_abnormal_gametogenesis1.76110164
35MP0005409_darkened_coat_color1.75890325
36MP0000778_abnormal_nervous_system1.72752166
37MP0001348_abnormal_lacrimal_gland1.72612447
38MP0004185_abnormal_adipocyte_glucose1.71897347
39MP0004270_analgesia1.69522513
40MP0010094_abnormal_chromosome_stability1.69317660
41MP0005023_abnormal_wound_healing1.69133143
42MP0001958_emphysema1.69029716
43MP0003453_abnormal_keratinocyte_physiol1.68169322
44MP0000003_abnormal_adipose_tissue1.67689605
45MP0003172_abnormal_lysosome_physiology1.63784257
46MP0004233_abnormal_muscle_weight1.63747208
47MP0008995_early_reproductive_senescence1.61908412
48MP0001529_abnormal_vocalization1.61441922
49MP0003693_abnormal_embryo_hatching1.57774055
50MP0003786_premature_aging1.56503635
51MP0010352_gastrointestinal_tract_polyps1.56022868
52MP0009046_muscle_twitch1.55824013
53MP0004272_abnormal_basement_membrane1.54434385
54MP0006276_abnormal_autonomic_nervous1.54288696
55MP0004858_abnormal_nervous_system1.53500824
56MP0005501_abnormal_skin_physiology1.52113815
57MP0004808_abnormal_hematopoietic_stem1.51758637
58MP0003385_abnormal_body_wall1.50521857
59MP0003077_abnormal_cell_cycle1.48057776
60MP0002184_abnormal_innervation1.46676006
61MP0001730_embryonic_growth_arrest1.42528543
62MP0008438_abnormal_cutaneous_collagen1.41018868
63MP0002796_impaired_skin_barrier1.40336771
64MP0002736_abnormal_nociception_after1.40303946
65MP0003950_abnormal_plasma_membrane1.38636623
66MP0003121_genomic_imprinting1.38294592
67MP0001243_abnormal_dermal_layer1.37468653
68MP0005171_absent_coat_pigmentation1.36540892
69MP0002067_abnormal_sensory_capabilities1.36502046
70MP0000013_abnormal_adipose_tissue1.34970066
71MP0005503_abnormal_tendon_morphology1.34372708
72MP0003279_aneurysm1.33922942
73MP0002572_abnormal_emotion/affect_behav1.29001786
74MP0002127_abnormal_cardiovascular_syste1.27858998
75MP0002896_abnormal_bone_mineralization1.27705309
76MP0010368_abnormal_lymphatic_system1.27085383
77MP0002064_seizures1.26547580
78MP0001486_abnormal_startle_reflex1.25732837
79MP0008007_abnormal_cellular_replicative1.25043546
80MP0001145_abnormal_male_reproductive1.24685137
81MP0000751_myopathy1.24673079
82MP0000653_abnormal_sex_gland1.20857802
83MP0008961_abnormal_basal_metabolism1.20714993
84MP0010307_abnormal_tumor_latency1.20338852
85MP0002161_abnormal_fertility/fecundity1.19745308
86MP0001440_abnormal_grooming_behavior1.18506860
87MP0001984_abnormal_olfaction1.18141725
88MP0000015_abnormal_ear_pigmentation1.16319361
89MP0004924_abnormal_behavior1.15905230
90MP0005386_behavior/neurological_phenoty1.15905230
91MP0002272_abnormal_nervous_system1.15705892
92MP0000350_abnormal_cell_proliferation1.15447764
93MP0005666_abnormal_adipose_tissue1.13013239
94MP0002396_abnormal_hematopoietic_system1.12775380
95MP0004957_abnormal_blastocyst_morpholog1.12030872
96MP0002249_abnormal_larynx_morphology1.11894077
97MP0005621_abnormal_cell_physiology1.09471258
98MP0000767_abnormal_smooth_muscle1.09196046
99MP0005389_reproductive_system_phenotype1.08944120
100MP0001968_abnormal_touch/_nociception1.08052448
101MP0008058_abnormal_DNA_repair1.07291581
102MP0003091_abnormal_cell_migration1.06825096
103MP0001216_abnormal_epidermal_layer1.06629337
104MP0005375_adipose_tissue_phenotype1.06114722
105MP0002152_abnormal_brain_morphology1.05937833
106MP0003890_abnormal_embryonic-extraembry1.05797339
107MP0004811_abnormal_neuron_physiology1.05492433
108MP0002086_abnormal_extraembryonic_tissu1.04848706
109MP0003115_abnormal_respiratory_system1.04838589
110MP0003937_abnormal_limbs/digits/tail_de1.04673082
111MP0002080_prenatal_lethality1.04404387
112MP0002089_abnormal_postnatal_growth/wei1.02741892
113MP0008932_abnormal_embryonic_tissue1.02720495
114MP0000858_altered_metastatic_potential1.02456662
115MP0002734_abnormal_mechanical_nocicepti1.01546403
116MP0002653_abnormal_ependyma_morphology1.00880019
117MP0000733_abnormal_muscle_development1.00647839
118MP0002557_abnormal_social/conspecific_i1.00466502
119MP0008569_lethality_at_weaning1.00047155
120MP0005076_abnormal_cell_differentiation0.99748845
121MP0009672_abnormal_birth_weight0.99381823
122MP0003283_abnormal_digestive_organ0.96672426
123MP0003984_embryonic_growth_retardation0.96561920
124MP0001672_abnormal_embryogenesis/_devel0.96340067
125MP0005380_embryogenesis_phenotype0.96340067
126MP0000537_abnormal_urethra_morphology0.96195330
127MP0005646_abnormal_pituitary_gland0.95182741
128MP0000631_abnormal_neuroendocrine_gland0.93700210
129MP0005360_urolithiasis0.92876924
130MP0003861_abnormal_nervous_system0.92121227
131MP0004134_abnormal_chest_morphology0.90729394
132MP0002970_abnormal_white_adipose0.89874644
133MP0010771_integument_phenotype0.89655172
134MP0002088_abnormal_embryonic_growth/wei0.89646409
135MP0003868_abnormal_feces_composition0.89308588
136MP0002084_abnormal_developmental_patter0.87730922
137MP0005595_abnormal_vascular_smooth0.87541838
138MP0000762_abnormal_tongue_morphology0.87449429
139MP0002882_abnormal_neuron_morphology0.86613465
140MP0009703_decreased_birth_body0.86463948
141MP0009384_cardiac_valve_regurgitation0.85698488
142MP0002233_abnormal_nose_morphology0.85012943
143MP0003755_abnormal_palate_morphology0.84524924
144MP0009931_abnormal_skin_appearance0.84377037
145MP0002075_abnormal_coat/hair_pigmentati0.83517609
146MP0004197_abnormal_fetal_growth/weight/0.83492911
147MP0004947_skin_inflammation0.83471106
148MP0001697_abnormal_embryo_size0.83429228
149MP0002085_abnormal_embryonic_tissue0.82612745
150MP0000955_abnormal_spinal_cord0.82563826
151MP0002925_abnormal_cardiovascular_devel0.81888865
152MP0000313_abnormal_cell_death0.81423895
153MP0002066_abnormal_motor_capabilities/c0.81288791
154MP0001919_abnormal_reproductive_system0.80840444
155MP0005384_cellular_phenotype0.80780284
156MP0002116_abnormal_craniofacial_bone0.80418700
157MP0000467_abnormal_esophagus_morphology0.79977123
158MP0005508_abnormal_skeleton_morphology0.78963598
159MP0005551_abnormal_eye_electrophysiolog0.78851139
160MP0003942_abnormal_urinary_system0.78796070
161MP0003122_maternal_imprinting0.78766468
162MP0000759_abnormal_skeletal_muscle0.78519948
163MP0000534_abnormal_ureter_morphology0.77591746
164MP0003123_paternal_imprinting0.77028777
165MP0005257_abnormal_intraocular_pressure0.76625612
166MP0000358_abnormal_cell_content/0.76574247
167MP0000647_abnormal_sebaceous_gland0.76245858
168MP0001177_atelectasis0.75596702
169MP0009250_abnormal_appendicular_skeleto0.75195111
170MP0009278_abnormal_bone_marrow0.75175650
171MP0002081_perinatal_lethality0.73958745
172MP0003763_abnormal_thymus_physiology0.73858537
173MP0003111_abnormal_nucleus_morphology0.73748430
174MP0002114_abnormal_axial_skeleton0.73266621
175MP0002160_abnormal_reproductive_system0.73127231
176MP0002109_abnormal_limb_morphology0.71938651
177MP0004085_abnormal_heartbeat0.71765001
178MP0008770_decreased_survivor_rate0.71505962
179MP0008057_abnormal_DNA_replication0.71394256
180MP0002108_abnormal_muscle_morphology0.71281570

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)8.65508943
2Asymmetry of the thorax (HP:0001555)6.79642651
3Thoracic kyphosis (HP:0002942)5.82089648
4Thyroid-stimulating hormone excess (HP:0002925)4.87858486
5Hypoplasia of the capital femoral epiphysis (HP:0003090)4.87653974
6Aplasia/Hypoplasia of the fibula (HP:0006492)4.84906485
7Fibular hypoplasia (HP:0003038)4.75303638
8Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.54454110
9Focal segmental glomerulosclerosis (HP:0000097)4.42083309
10Abnormality of the thoracic spine (HP:0100711)4.17897468
11Partial agenesis of the corpus callosum (HP:0001338)4.13436414
12Aplasia of the phalanges of the hand (HP:0009802)4.09615884
13Aplasia involving bones of the extremities (HP:0009825)4.09615884
14Aplasia involving bones of the upper limbs (HP:0009823)4.09615884
15Broad face (HP:0000283)3.96257344
16Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.92057089
17Absent epiphyses (HP:0010577)3.92057089
18Wrist flexion contracture (HP:0001239)3.89233685
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.64937305
20Cervical subluxation (HP:0003308)3.52388466
21Short tibia (HP:0005736)3.50246266
22Short nail (HP:0001799)3.50162870
23Aplasia/Hypoplasia of the tibia (HP:0005772)3.43804445
24Natal tooth (HP:0000695)3.39025642
25Biconcave vertebral bodies (HP:0004586)3.16254961
26Hyperacusis (HP:0010780)3.11835821
27Glomerulosclerosis (HP:0000096)3.10156126
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.08010522
29Absent/shortened dynein arms (HP:0200106)3.08010522
30Wide intermamillary distance (HP:0006610)3.06969569
31Broad ribs (HP:0000885)3.00114042
32J-shaped sella turcica (HP:0002680)2.94997812
33Neoplasm of the adrenal cortex (HP:0100641)2.93621840
34Ulnar bowing (HP:0003031)2.92441759
35Entropion (HP:0000621)2.92129200
36High pitched voice (HP:0001620)2.85931736
37Distal lower limb amyotrophy (HP:0008944)2.82664386
38Cerebral aneurysm (HP:0004944)2.81078281
39Bell-shaped thorax (HP:0001591)2.80972069
40Distal upper limb amyotrophy (HP:0007149)2.78135912
41Upper limb amyotrophy (HP:0009129)2.78135912
42Tracheomalacia (HP:0002779)2.74166528
43Thin bony cortex (HP:0002753)2.73998291
44Abnormal respiratory motile cilium physiology (HP:0012261)2.73900013
45Mitral regurgitation (HP:0001653)2.69885966
46Subacute progressive viral hepatitis (HP:0006572)2.67445036
47Fragile skin (HP:0001030)2.66898183
48Abnormality of the phalanges of the hallux (HP:0010057)2.66897929
49Increased connective tissue (HP:0009025)2.66239261
50Absent hand (HP:0004050)2.65005871
51Abnormality of the lumbar spine (HP:0100712)2.58466956
52Disproportionate short-trunk short stature (HP:0003521)2.57003054
53Abnormality of dentin (HP:0010299)2.55950872
54Abnormality of the lower motor neuron (HP:0002366)2.55435432
55Ankyloglossia (HP:0010296)2.47556402
56Cutaneous finger syndactyly (HP:0010554)2.46160341
57High anterior hairline (HP:0009890)2.45224414
58Abnormality of the fibula (HP:0002991)2.41672654
59Delayed closure of the anterior fontanelle (HP:0001476)2.40847343
60Vertebral compression fractures (HP:0002953)2.40311638
61Anal stenosis (HP:0002025)2.38552308
62Broad distal phalanx of finger (HP:0009836)2.36864109
63Bladder diverticulum (HP:0000015)2.36586143
64Difficulty climbing stairs (HP:0003551)2.35195441
65Elbow flexion contracture (HP:0002987)2.34934082
66Wormian bones (HP:0002645)2.33437944
67Short humerus (HP:0005792)2.32559013
68Shallow orbits (HP:0000586)2.32140346
69Spinal rigidity (HP:0003306)2.30818168
70Rhinitis (HP:0012384)2.29354641
7111 pairs of ribs (HP:0000878)2.27937614
72Hepatoblastoma (HP:0002884)2.26422988
73Dislocated radial head (HP:0003083)2.23545238
74Ankle contracture (HP:0006466)2.22449667
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21783665
76Atrophic scars (HP:0001075)2.20692248
77Selective tooth agenesis (HP:0001592)2.20445023
78Curly hair (HP:0002212)2.19422673
79Back pain (HP:0003418)2.19124958
80Long palpebral fissure (HP:0000637)2.17372377
81Abnormality of the distal phalanges of the toes (HP:0010182)2.17275727
82Mildly elevated creatine phosphokinase (HP:0008180)2.16533374
83Dilatation of the ascending aorta (HP:0005111)2.14924740
84Stridor (HP:0010307)2.14467727
85Abnormal ciliary motility (HP:0012262)2.13084030
86Absent frontal sinuses (HP:0002688)2.11564166
87Supernumerary ribs (HP:0005815)2.11289136
88Flat acetabular roof (HP:0003180)2.10906433
89Amblyopia (HP:0000646)2.10860171
90Hand muscle atrophy (HP:0009130)2.10706975
91Premature rupture of membranes (HP:0001788)2.10538660
92Aortic regurgitation (HP:0001659)2.10336662
93Premature skin wrinkling (HP:0100678)2.10262792
94Blue sclerae (HP:0000592)2.09844941
95Metaphyseal cupping (HP:0003021)2.08455987
96Gonadotropin excess (HP:0000837)2.08275462
97Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08062129
98Astrocytoma (HP:0009592)2.07172179
99Abnormality of the astrocytes (HP:0100707)2.07172179
100Abnormality of the radial head (HP:0003995)2.06648802
101Abnormality of the distal phalanx of the thumb (HP:0009617)2.06522300
102Abnormal respiratory motile cilium morphology (HP:0005938)2.06276923
103Abnormal respiratory epithelium morphology (HP:0012253)2.06276923
104Nasal speech (HP:0001611)2.05913877
105Duplication of thumb phalanx (HP:0009942)2.05797856
106Aplasia/hypoplasia of the humerus (HP:0006507)2.05649864
107Joint laxity (HP:0001388)2.05199423
108Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03751442
109Hypoplasia of the brainstem (HP:0002365)2.03751442
110Obstructive sleep apnea (HP:0002870)2.03673270
111Cutaneous syndactyly (HP:0012725)2.03160297
112Protruding tongue (HP:0010808)2.03108844
113Bifid uvula (HP:0000193)2.02110761
114Reticulocytosis (HP:0001923)2.02093660
115Advanced eruption of teeth (HP:0006288)2.02060302
116Abnormality of the calcaneus (HP:0008364)2.01619500
117Protrusio acetabuli (HP:0003179)1.99550178
118Joint stiffness (HP:0001387)1.98622571
119Achilles tendon contracture (HP:0001771)1.97555474
120Shoulder girdle muscle weakness (HP:0003547)1.93465325
121Coarse hair (HP:0002208)1.93217953
122Poikiloderma (HP:0001029)1.92464569
123Mesangial abnormality (HP:0001966)1.92014459
124Osteomalacia (HP:0002749)1.91979762
125Genu recurvatum (HP:0002816)1.90531560
126Trismus (HP:0000211)1.90164314
127Supernumerary bones of the axial skeleton (HP:0009144)1.89843761
128Mitral valve prolapse (HP:0001634)1.89083570
129Osteolytic defects of the hand bones (HP:0009699)1.88379428
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.88379428
131Abnormality of oral frenula (HP:0000190)1.88017823
132Long eyelashes (HP:0000527)1.87758954
133Abnormality of the acetabulum (HP:0003170)1.87431941
134Deviation of the thumb (HP:0009603)1.86951991
135Abnormal hair laboratory examination (HP:0003328)1.86778188
136Long foot (HP:0001833)1.86685542
137Aortic dissection (HP:0002647)1.86220766
138Aortic aneurysm (HP:0004942)1.85203953
139Bowing of the arm (HP:0006488)1.85010342
140Bowed forearm bones (HP:0003956)1.85010342
141Macroorchidism (HP:0000053)1.83186226
142Rhizomelia (HP:0008905)1.82529022
143Spondylolisthesis (HP:0003302)1.82066763
144Syringomyelia (HP:0003396)1.80889319
145Spinal cord lesions (HP:0100561)1.80889319
146Deformed sella turcica (HP:0002681)1.80692079
147Thin ribs (HP:0000883)1.80039287
148Fibroma (HP:0010614)1.79507768
149Soft skin (HP:0000977)1.79356620
150Aneurysm (HP:0002617)1.79085814
151Short clavicles (HP:0000894)1.78455516
152Rectal prolapse (HP:0002035)1.78256874
153Absent radius (HP:0003974)1.77325936
154Stomach cancer (HP:0012126)1.77083682
155Volvulus (HP:0002580)1.77071101
156Insomnia (HP:0100785)1.76447635
157Septo-optic dysplasia (HP:0100842)1.75801148
158Disproportionate tall stature (HP:0001519)1.75054632
159Venous abnormality (HP:0002624)1.74978231
160Blue irides (HP:0000635)1.72940530
161Squamous cell carcinoma (HP:0002860)1.72184286
162Amyotrophic lateral sclerosis (HP:0007354)1.72157122
163Lower limb amyotrophy (HP:0007210)1.71218789
164Fibrous tissue neoplasm (HP:0012316)1.71204241
165Chromsome breakage (HP:0040012)1.70549471
166Increased nuchal translucency (HP:0010880)1.70046499
167Abnormality of the tricuspid valve (HP:0001702)1.69327698
168Proximal placement of thumb (HP:0009623)1.69179519
169Heterotopia (HP:0002282)1.68886656
170Broad palm (HP:0001169)1.68791372
171Ureteral duplication (HP:0000073)1.67810912
172Atelectasis (HP:0100750)1.67547677
173Exotropia (HP:0000577)1.67434790
174Abnormality of skull ossification (HP:0002703)1.66879317
1752-3 toe syndactyly (HP:0004691)1.66838505
176Absent forearm bone (HP:0003953)1.66413972
177Aplasia involving forearm bones (HP:0009822)1.66413972
178Pili torti (HP:0003777)1.64610005
179Sparse lateral eyebrow (HP:0005338)1.64228627
180Abnormality of the Achilles tendon (HP:0005109)1.63919645
181Vertebral arch anomaly (HP:0008438)1.63794425
182Melanocytic nevus (HP:0000995)1.63740211
183Hyperpituitarism (HP:0010514)1.63135188
184Abnormality of subcutaneous fat tissue (HP:0001001)1.63122164
185Long toe (HP:0010511)1.62972195
186Ovoid vertebral bodies (HP:0003300)1.62062216
187Short chin (HP:0000331)1.61132218
188Hyperthyroidism (HP:0000836)1.58347786
189Abnormality of the corticospinal tract (HP:0002492)1.57875564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.30384073
2TRIB34.32287008
3CCNB14.18416610
4MET4.17235859
5MST1R3.95185069
6CDC73.35242968
7DYRK1B3.20957262
8NTRK33.13715146
9LATS13.01732469
10TAOK22.85716550
11SIK12.83837777
12SMG12.83569800
13MAP2K32.64838572
14CDK192.64409653
15EEF2K2.58632063
16EPHA22.49950370
17IRAK32.23900861
18PTK22.12252186
19MAP3K102.02988961
20BMX1.98612206
21EPHA31.92076673
22CDK121.90614505
23ERN11.87633300
24SGK21.85259565
25PDK31.76618887
26PDK41.76618887
27MAP3K61.62730265
28DYRK1A1.60761119
29STK381.59128772
30NTRK11.58082928
31WNK11.51872227
32MINK11.49545051
33PKN21.47567945
34SGK31.44444209
35CSNK1G21.43648847
36NME21.41561495
37MARK11.37902880
38PINK11.37656571
39FLT31.36959558
40PAK41.31601305
41SGK4941.27911017
42SGK2231.27911017
43MAP3K131.27376834
44CSNK1A1L1.27076853
45LATS21.26143300
46PDGFRB1.25831659
47OXSR11.23666121
48LMTK21.19222979
49FGFR41.14715289
50CSNK1G31.12424353
51CAMK1G1.08902970
52DDR21.07177681
53PAK61.06948684
54STK391.06432919
55TTN1.06269016
56ZAK1.04641468
57MAP2K61.00591286
58MAPK71.00551578
59PRKD20.99897797
60MAP3K70.98136261
61MAP3K140.94933526
62CDK30.94248638
63CDK80.93184724
64PDK20.92929976
65TTK0.92556780
66MAP3K30.91783637
67CAMK1D0.89974741
68TESK10.88566603
69SIK20.88528171
70PNCK0.88146643
71CDC42BPA0.87310066
72CDK40.85279998
73CSNK1G10.85238658
74ZAP700.84059151
75MAPK110.83615331
76PDGFRA0.83607042
77EPHA40.83560709
78RET0.82471304
79PTK2B0.81453106
80BRD40.80616971
81PTK60.80393369
82FRK0.77050539
83CAMKK10.74388838
84PLK20.74336801
85CDK70.73305766
86MAP3K20.71007936
87JAK30.68882228
88ADRBK10.68832720
89WNK40.68506286
90MYLK0.65427653
91FGR0.65323192
92FGFR20.65318949
93STK30.65257427
94PRKD30.64858949
95KSR10.64397499
96CDK150.64363072
97CDK11A0.62515277
98TYRO30.61424272
99EPHB10.60545418
100CDK180.60522064
101MTOR0.60107462
102MAP3K80.59703512
103CDK50.59670448
104SGK10.59452905
105MARK20.59327486
106AKT20.59011577
107PDPK10.58842498
108CHEK20.58744029
109BRSK10.58373139
110RPS6KB20.57191559
111RPS6KA20.55496774
112NEK20.55269310
113FGFR10.54443007
114NME10.53312370
115CDK60.52977007
116NTRK20.50759613
117WEE10.50291184
118BUB10.50236264
119NEK90.49718422
120MAP2K20.49490873
121MAP3K40.49451616
122MAPK90.48332243
123RPS6KC10.48274159
124RPS6KL10.48274159
125MAPK80.47297256
126ALK0.46840825
127CDK140.45431569
128GSK3B0.44865568
129DAPK20.44693535
130CDK20.44026124
131MELK0.43871899
132PIM20.42901270
133PRPF4B0.42596203
134CSNK1D0.42003208
135FGFR30.41609650
136PAK30.40967250
137CSF1R0.40861751
138CDK90.40683456
139BRAF0.40319479
140AKT10.39302035
141PRKCG0.38995623
142CDK10.38871309
143MAPK120.38714040
144MAPKAPK20.38649467
145CHEK10.38346898
146CAMKK20.38051049
147RAF10.37830380
148PRKCI0.37786172
149PAK20.37077237
150AURKA0.36588220
151ERBB30.36359845
152PRKG10.36245831
153IRAK20.35888543
154CLK10.35522927
155FER0.34820928
156RIPK10.34706595
157KSR20.34503295
158SCYL20.33663804
159ATR0.32123734
160RPS6KA30.31886158
161CSNK1E0.31582486
162MAPK10.30519719
163RPS6KA60.30440813
164TRPM70.30011602
165CAMK2B0.29592481

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55749799
2Dorso-ventral axis formation_Homo sapiens_hsa043203.02148095
3Other glycan degradation_Homo sapiens_hsa005112.96379163
4DNA replication_Homo sapiens_hsa030302.56572826
5Cocaine addiction_Homo sapiens_hsa050302.50638715
6Taste transduction_Homo sapiens_hsa047422.23562072
7Amphetamine addiction_Homo sapiens_hsa050312.22431621
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.19686488
9Long-term potentiation_Homo sapiens_hsa047202.18421496
10Circadian entrainment_Homo sapiens_hsa047132.11149113
11Glutamatergic synapse_Homo sapiens_hsa047242.05117992
12Small cell lung cancer_Homo sapiens_hsa052222.03814490
13Basal cell carcinoma_Homo sapiens_hsa052171.98406351
14Base excision repair_Homo sapiens_hsa034101.97962494
15Endometrial cancer_Homo sapiens_hsa052131.96165477
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90453770
17Notch signaling pathway_Homo sapiens_hsa043301.81725522
18Cell cycle_Homo sapiens_hsa041101.74857239
19Wnt signaling pathway_Homo sapiens_hsa043101.70815839
20Bladder cancer_Homo sapiens_hsa052191.69215439
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68340903
22VEGF signaling pathway_Homo sapiens_hsa043701.68028872
23Axon guidance_Homo sapiens_hsa043601.67425248
24Gap junction_Homo sapiens_hsa045401.67221144
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.60191073
26Phototransduction_Homo sapiens_hsa047441.59685276
27mTOR signaling pathway_Homo sapiens_hsa041501.57922133
28GnRH signaling pathway_Homo sapiens_hsa049121.55747673
29Salivary secretion_Homo sapiens_hsa049701.50046845
30Sulfur relay system_Homo sapiens_hsa041221.46507655
31Circadian rhythm_Homo sapiens_hsa047101.45998923
32Estrogen signaling pathway_Homo sapiens_hsa049151.45309465
33ErbB signaling pathway_Homo sapiens_hsa040121.43234207
34mRNA surveillance pathway_Homo sapiens_hsa030151.42348019
35Hippo signaling pathway_Homo sapiens_hsa043901.41983241
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40480677
37Lysine degradation_Homo sapiens_hsa003101.39884081
38Pancreatic cancer_Homo sapiens_hsa052121.39013576
39Long-term depression_Homo sapiens_hsa047301.38311172
40Hedgehog signaling pathway_Homo sapiens_hsa043401.38295598
41Calcium signaling pathway_Homo sapiens_hsa040201.37829953
42Nucleotide excision repair_Homo sapiens_hsa034201.36000944
43Mismatch repair_Homo sapiens_hsa034301.35379307
44Thyroid cancer_Homo sapiens_hsa052161.35318954
45RNA transport_Homo sapiens_hsa030131.35210394
46Morphine addiction_Homo sapiens_hsa050321.34142766
47Glioma_Homo sapiens_hsa052141.32089009
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31764997
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31068605
50Synaptic vesicle cycle_Homo sapiens_hsa047211.29599849
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28802936
52Cholinergic synapse_Homo sapiens_hsa047251.24636554
53Fructose and mannose metabolism_Homo sapiens_hsa000511.23478003
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22645403
55One carbon pool by folate_Homo sapiens_hsa006701.21665247
56Insulin secretion_Homo sapiens_hsa049111.19545395
57Dopaminergic synapse_Homo sapiens_hsa047281.17369345
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.15791965
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15556118
60Oxytocin signaling pathway_Homo sapiens_hsa049211.15110450
61Fanconi anemia pathway_Homo sapiens_hsa034601.12816710
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12203306
63Inositol phosphate metabolism_Homo sapiens_hsa005621.11931278
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11283667
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10272117
66MAPK signaling pathway_Homo sapiens_hsa040101.09862278
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08925617
68ECM-receptor interaction_Homo sapiens_hsa045121.07257987
69Pentose phosphate pathway_Homo sapiens_hsa000301.07227389
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07129699
71Renin secretion_Homo sapiens_hsa049241.06331196
72Alcoholism_Homo sapiens_hsa050341.05239720
73Ovarian steroidogenesis_Homo sapiens_hsa049131.03695517
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03589014
75GABAergic synapse_Homo sapiens_hsa047271.01080325
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00717766
77cAMP signaling pathway_Homo sapiens_hsa040240.98160192
78Biosynthesis of amino acids_Homo sapiens_hsa012300.98094724
79Shigellosis_Homo sapiens_hsa051310.96661052
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95767689
81Focal adhesion_Homo sapiens_hsa045100.95711607
82Acute myeloid leukemia_Homo sapiens_hsa052210.95088742
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94402653
84p53 signaling pathway_Homo sapiens_hsa041150.93124057
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91651757
86Olfactory transduction_Homo sapiens_hsa047400.91549626
87Chronic myeloid leukemia_Homo sapiens_hsa052200.89872475
88Renal cell carcinoma_Homo sapiens_hsa052110.89430815
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.89338949
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88963013
91Serotonergic synapse_Homo sapiens_hsa047260.88792575
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.88715047
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88495653
94N-Glycan biosynthesis_Homo sapiens_hsa005100.88250998
95Insulin signaling pathway_Homo sapiens_hsa049100.87792374
96Type II diabetes mellitus_Homo sapiens_hsa049300.87234226
97Viral carcinogenesis_Homo sapiens_hsa052030.86879003
98Dilated cardiomyopathy_Homo sapiens_hsa054140.86669198
99HTLV-I infection_Homo sapiens_hsa051660.86615123
100Homologous recombination_Homo sapiens_hsa034400.86613480
101Gastric acid secretion_Homo sapiens_hsa049710.82570928
102Prostate cancer_Homo sapiens_hsa052150.82424877
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82338469
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82133590
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81903860
106Spliceosome_Homo sapiens_hsa030400.81313964
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80090622
108Ras signaling pathway_Homo sapiens_hsa040140.79762023
109Galactose metabolism_Homo sapiens_hsa000520.78774947
110Apoptosis_Homo sapiens_hsa042100.77442206
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76764357
112Prolactin signaling pathway_Homo sapiens_hsa049170.75761858
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75481159
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75260024
115Melanogenesis_Homo sapiens_hsa049160.75210061
116MicroRNAs in cancer_Homo sapiens_hsa052060.74602244
117AMPK signaling pathway_Homo sapiens_hsa041520.74135375
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73989655
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73803410
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73794469
121Proteoglycans in cancer_Homo sapiens_hsa052050.73373083
122Rap1 signaling pathway_Homo sapiens_hsa040150.72819417
123Pyrimidine metabolism_Homo sapiens_hsa002400.72585633
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71872892
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71628289
126Hepatitis B_Homo sapiens_hsa051610.71560603
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70556124
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70556108
129Melanoma_Homo sapiens_hsa052180.69615683
130Non-homologous end-joining_Homo sapiens_hsa034500.68279974
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67262257
132TNF signaling pathway_Homo sapiens_hsa046680.66916331
133Tight junction_Homo sapiens_hsa045300.66327963
134Oocyte meiosis_Homo sapiens_hsa041140.65435645
135FoxO signaling pathway_Homo sapiens_hsa040680.63120201
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62430939
137Choline metabolism in cancer_Homo sapiens_hsa052310.61466663
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61409601
139T cell receptor signaling pathway_Homo sapiens_hsa046600.61372790
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61371048
141Colorectal cancer_Homo sapiens_hsa052100.60345538
142Fatty acid biosynthesis_Homo sapiens_hsa000610.60309915
143Cardiac muscle contraction_Homo sapiens_hsa042600.58684181
144Insulin resistance_Homo sapiens_hsa049310.58353673
145Selenocompound metabolism_Homo sapiens_hsa004500.58319196
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.57999819
147Glucagon signaling pathway_Homo sapiens_hsa049220.57328977
148Hepatitis C_Homo sapiens_hsa051600.57315940
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.56956689
150Non-small cell lung cancer_Homo sapiens_hsa052230.56862754
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54525433
152Pathways in cancer_Homo sapiens_hsa052000.54238043
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52243202
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.51815353
155TGF-beta signaling pathway_Homo sapiens_hsa043500.50877894
156Endocytosis_Homo sapiens_hsa041440.50705684
157Amoebiasis_Homo sapiens_hsa051460.50607102
158Adherens junction_Homo sapiens_hsa045200.49651188
159HIF-1 signaling pathway_Homo sapiens_hsa040660.48877252
160Protein digestion and absorption_Homo sapiens_hsa049740.48122721
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.47815131
162Lysosome_Homo sapiens_hsa041420.47403701
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.42525286

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