PLEKHG4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.89166449
2regulation of gene silencing by miRNA (GO:0060964)4.89166449
3regulation of gene silencing by RNA (GO:0060966)4.89166449
4pre-miRNA processing (GO:0031054)4.25130759
5lateral sprouting from an epithelium (GO:0060601)4.05662478
6lung-associated mesenchyme development (GO:0060484)3.93587264
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.84758954
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.84758954
9regulation of translation, ncRNA-mediated (GO:0045974)3.84758954
10paraxial mesoderm development (GO:0048339)3.60705875
11presynaptic membrane assembly (GO:0097105)3.45760715
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44170132
13convergent extension (GO:0060026)3.29226319
14behavioral response to nicotine (GO:0035095)3.29135932
15kidney morphogenesis (GO:0060993)3.21009433
16regulation of non-canonical Wnt signaling pathway (GO:2000050)3.19219250
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13194564
18neuronal stem cell maintenance (GO:0097150)3.09642167
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09349977
20postsynaptic membrane organization (GO:0001941)3.07091834
21notochord development (GO:0030903)3.05943381
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.05383909
23somite development (GO:0061053)3.01539410
24presynaptic membrane organization (GO:0097090)3.01380860
25heterochromatin organization (GO:0070828)3.00989816
26appendage development (GO:0048736)2.99107197
27limb development (GO:0060173)2.99107197
28pyrimidine nucleobase catabolic process (GO:0006208)2.91192055
29nonmotile primary cilium assembly (GO:0035058)2.90938859
30chromatin remodeling at centromere (GO:0031055)2.87805907
31intraciliary transport (GO:0042073)2.84857200
32outer ear morphogenesis (GO:0042473)2.83120919
33cornea development in camera-type eye (GO:0061303)2.79514231
34spinal cord development (GO:0021510)2.78835147
35epithelial cilium movement (GO:0003351)2.78073775
36regulation of mesoderm development (GO:2000380)2.73757813
37limb bud formation (GO:0060174)2.73689500
38cell proliferation in forebrain (GO:0021846)2.73488134
39establishment of tissue polarity (GO:0007164)2.72777117
40establishment of planar polarity (GO:0001736)2.72777117
41cilium movement (GO:0003341)2.67335262
42regulation of cell fate specification (GO:0042659)2.66735316
43Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66387069
44DNA strand renaturation (GO:0000733)2.65646104
45dorsal/ventral axis specification (GO:0009950)2.64902496
46regulation of hippo signaling (GO:0035330)2.62411419
47establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59896240
48somatic stem cell division (GO:0048103)2.59531679
49mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57603076
50replication fork processing (GO:0031297)2.55644470
51digestive tract morphogenesis (GO:0048546)2.55408617
52tongue development (GO:0043586)2.55366769
53CENP-A containing nucleosome assembly (GO:0034080)2.52831317
54non-canonical Wnt signaling pathway (GO:0035567)2.52393228
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.50042452
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50042452
57prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.50004442
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.49937758
59hindbrain development (GO:0030902)2.49910048
60pituitary gland development (GO:0021983)2.49822270
61otic vesicle formation (GO:0030916)2.49481700
62cranial nerve development (GO:0021545)2.49325301
63regulation of establishment of planar polarity (GO:0090175)2.48574064
64establishment of monopolar cell polarity (GO:0061162)2.41275045
65establishment or maintenance of monopolar cell polarity (GO:0061339)2.41275045
66DNA double-strand break processing (GO:0000729)2.41154788
67protein-DNA complex disassembly (GO:0032986)2.41129052
68nucleosome disassembly (GO:0006337)2.41129052
69apical protein localization (GO:0045176)2.40004103
70ncRNA catabolic process (GO:0034661)2.39998780
71organ growth (GO:0035265)2.37632009
72generation of neurons (GO:0048699)2.37454476
73establishment of apical/basal cell polarity (GO:0035089)2.36139068
74kinetochore organization (GO:0051383)2.35880768
75regulation of gene silencing (GO:0060968)2.35840201
76L-serine metabolic process (GO:0006563)2.34778046
77kinetochore assembly (GO:0051382)2.34150767
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.33363641
79midbrain development (GO:0030901)2.33095760
80olfactory bulb development (GO:0021772)2.31217640
81regulation of cell fate commitment (GO:0010453)2.29032240
82branching involved in salivary gland morphogenesis (GO:0060445)2.28539861
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.28156360
84histone exchange (GO:0043486)2.23726203
85cilium organization (GO:0044782)2.22790665
86axonal fasciculation (GO:0007413)2.22363968
87calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.21377039
88DNA replication checkpoint (GO:0000076)2.20919080
89ATP-dependent chromatin remodeling (GO:0043044)2.20656349
90transmission of nerve impulse (GO:0019226)2.20461473
91cilium assembly (GO:0042384)2.20013410
92thalamus development (GO:0021794)2.19631669
93smoothened signaling pathway (GO:0007224)2.19259929
94cell migration in hindbrain (GO:0021535)2.17409944
95cellular response to cholesterol (GO:0071397)2.17408353
96regulation of stem cell maintenance (GO:2000036)2.17082519
97negative regulation of astrocyte differentiation (GO:0048712)2.17058420
98mesenchymal to epithelial transition (GO:0060231)2.16740143
99histone H3-K9 methylation (GO:0051567)2.15165516
100serine family amino acid catabolic process (GO:0009071)2.15140050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84194031
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.37346815
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01429625
4ZNF274_21170338_ChIP-Seq_K562_Hela2.50160655
5E2F7_22180533_ChIP-Seq_HELA_Human2.48158522
6POU5F1_16153702_ChIP-ChIP_HESCs_Human2.34665808
7VDR_22108803_ChIP-Seq_LS180_Human2.17796491
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16025929
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12778075
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10357638
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.04690302
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02252052
13SOX2_16153702_ChIP-ChIP_HESCs_Human2.01139476
14TP63_19390658_ChIP-ChIP_HaCaT_Human1.98305048
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.92336673
16* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90213958
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.83468478
18* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81927360
19GBX2_23144817_ChIP-Seq_PC3_Human1.78929836
20IGF1R_20145208_ChIP-Seq_DFB_Human1.68848478
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68683755
22EWS_26573619_Chip-Seq_HEK293_Human1.68073544
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.67739649
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64089924
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64089924
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64089924
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63759547
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.61324624
29IRF1_19129219_ChIP-ChIP_H3396_Human1.60517370
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60006810
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59313562
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59313562
33FUS_26573619_Chip-Seq_HEK293_Human1.58292695
34RNF2_27304074_Chip-Seq_NSC_Mouse1.57932167
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56430218
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55646336
37P300_19829295_ChIP-Seq_ESCs_Human1.55136793
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54923343
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.47417405
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43218022
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42769913
42REST_21632747_ChIP-Seq_MESCs_Mouse1.40256801
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38397015
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.38058527
45DROSHA_22980978_ChIP-Seq_HELA_Human1.36635920
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34903317
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34463688
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.33822151
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.32442780
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31853364
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31055331
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27956507
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27856783
54TAF15_26573619_Chip-Seq_HEK293_Human1.27347279
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25709431
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25448292
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25448292
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24116178
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.20853064
60MYC_18940864_ChIP-ChIP_HL60_Human1.16964097
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15339569
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15050806
63TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14816323
64SMAD3_21741376_ChIP-Seq_ESCs_Human1.14487267
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.12993472
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11724881
67* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11683534
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.10899540
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10354599
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.08267393
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07834647
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.06979386
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06387139
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05280185
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04743222
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03518974
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01382496
78RING1B_27294783_Chip-Seq_NPCs_Mouse0.98779885
79SOX9_26525672_Chip-Seq_HEART_Mouse0.96903372
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96771121
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96160467
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95019929
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94807275
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93667536
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93278130
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92958275
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92927657
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.92493574
89* RUNX2_22187159_ChIP-Seq_PCA_Human0.92261530
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91314563
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.90808094
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90315682
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.90224066
94STAT3_23295773_ChIP-Seq_U87_Human0.90137806
95BCAT_22108803_ChIP-Seq_LS180_Human0.90105242
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89047886
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89024142
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87670498
99TCF4_22108803_ChIP-Seq_LS180_Human0.87263051
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.86816183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.29755308
2MP0003878_abnormal_ear_physiology3.29755308
3MP0006292_abnormal_olfactory_placode3.23551546
4MP0000566_synostosis3.16249197
5MP0003136_yellow_coat_color3.01461225
6MP0010030_abnormal_orbit_morphology3.00376082
7MP0002653_abnormal_ependyma_morphology2.62015830
8MP0001293_anophthalmia2.31595729
9MP0002254_reproductive_system_inflammat2.23990072
10MP0002938_white_spotting2.01498220
11MP0003937_abnormal_limbs/digits/tail_de2.00747844
12MP0003119_abnormal_digestive_system1.95533721
13MP0004133_heterotaxia1.93474601
14MP0000049_abnormal_middle_ear1.85165856
15MP0000778_abnormal_nervous_system1.82270839
16MP0008877_abnormal_DNA_methylation1.76769872
17MP0002697_abnormal_eye_size1.76347146
18MP0003890_abnormal_embryonic-extraembry1.73324882
19MP0003941_abnormal_skin_development1.72895026
20MP0003122_maternal_imprinting1.72779915
21MP0003787_abnormal_imprinting1.69700119
22MP0008789_abnormal_olfactory_epithelium1.63420107
23MP0001346_abnormal_lacrimal_gland1.61810955
24MP0000631_abnormal_neuroendocrine_gland1.60243676
25MP0003938_abnormal_ear_development1.59450462
26MP0005394_taste/olfaction_phenotype1.54311997
27MP0005499_abnormal_olfactory_system1.54311997
28MP0001485_abnormal_pinna_reflex1.52907814
29MP0002233_abnormal_nose_morphology1.49225948
30MP0002249_abnormal_larynx_morphology1.44594482
31MP0001286_abnormal_eye_development1.43667714
32MP0003693_abnormal_embryo_hatching1.43660578
33MP0003861_abnormal_nervous_system1.40169110
34MP0003121_genomic_imprinting1.35837487
35MP0003942_abnormal_urinary_system1.34714293
36MP0000537_abnormal_urethra_morphology1.33025262
37MP0003283_abnormal_digestive_organ1.31918732
38MP0000428_abnormal_craniofacial_morphol1.30548611
39MP0003755_abnormal_palate_morphology1.29792839
40MP0001984_abnormal_olfaction1.29663416
41MP0001299_abnormal_eye_distance/1.27302878
42MP0000579_abnormal_nail_morphology1.25727012
43MP0003880_abnormal_central_pattern1.24552009
44MP0000026_abnormal_inner_ear1.22155862
45MP0006276_abnormal_autonomic_nervous1.21968883
46MP0010094_abnormal_chromosome_stability1.19713333
47MP0006072_abnormal_retinal_apoptosis1.18823056
48MP0002102_abnormal_ear_morphology1.18365433
49MP0008058_abnormal_DNA_repair1.17636454
50MP0002111_abnormal_tail_morphology1.14731950
51MP0002736_abnormal_nociception_after1.12296803
52MP0002557_abnormal_social/conspecific_i1.10604094
53MP0002116_abnormal_craniofacial_bone1.09208913
54MP0003567_abnormal_fetal_cardiomyocyte1.07868714
55MP0001529_abnormal_vocalization1.07658691
56MP0000383_abnormal_hair_follicle1.07083583
57MP0009053_abnormal_anal_canal1.06768399
58MP0009672_abnormal_birth_weight1.06441307
59MP0002085_abnormal_embryonic_tissue1.05941974
60MP0008932_abnormal_embryonic_tissue1.04425384
61MP0002084_abnormal_developmental_patter1.02503286
62MP0002751_abnormal_autonomic_nervous1.02290102
63MP0005391_vision/eye_phenotype1.02253324
64MP0002092_abnormal_eye_morphology1.01590056
65MP0003385_abnormal_body_wall1.01530411
66MP0002752_abnormal_somatic_nervous1.00718277
67MP0002184_abnormal_innervation0.99205715
68MP0001968_abnormal_touch/_nociception0.98697502
69MP0002638_abnormal_pupillary_reflex0.98593580
70MP0002152_abnormal_brain_morphology0.97811220
71MP0000955_abnormal_spinal_cord0.97334111
72MP0005248_abnormal_Harderian_gland0.96070213
73MP0005551_abnormal_eye_electrophysiolog0.96060671
74MP0000432_abnormal_head_morphology0.94117909
75MP0001486_abnormal_startle_reflex0.93521861
76MP0003718_maternal_effect0.91930919
77MP0002822_catalepsy0.90179644
78MP0004142_abnormal_muscle_tone0.90096262
79MP0001188_hyperpigmentation0.89371596
80MP0003935_abnormal_craniofacial_develop0.89067574
81MP0002234_abnormal_pharynx_morphology0.88597844
82MP0005195_abnormal_posterior_eye0.88071848
83MP0008057_abnormal_DNA_replication0.87475062
84MP0002735_abnormal_chemical_nociception0.87108947
85MP0009745_abnormal_behavioral_response0.86832663
86MP0009379_abnormal_foot_pigmentation0.86133983
87MP0004885_abnormal_endolymph0.85803806
88MP0003111_abnormal_nucleus_morphology0.85133618
89MP0001963_abnormal_hearing_physiology0.84380912
90MP0005253_abnormal_eye_physiology0.82823484
91MP0002734_abnormal_mechanical_nocicepti0.82086253
92MP0002572_abnormal_emotion/affect_behav0.81930216
93MP0000647_abnormal_sebaceous_gland0.81019297
94MP0009250_abnormal_appendicular_skeleto0.79839665
95MP0008872_abnormal_physiological_respon0.77119190
96MP0009703_decreased_birth_body0.75620067
97MP0002882_abnormal_neuron_morphology0.75254409
98MP0002733_abnormal_thermal_nociception0.74807458
99MP0002282_abnormal_trachea_morphology0.74387846
100MP0002932_abnormal_joint_morphology0.73768745

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)3.32559135
2Genetic anticipation (HP:0003743)3.23913232
3Anophthalmia (HP:0000528)3.15437101
4Bilateral microphthalmos (HP:0007633)2.97857647
5Abnormality of the labia minora (HP:0012880)2.83873575
6Colon cancer (HP:0003003)2.81163316
7True hermaphroditism (HP:0010459)2.77471146
8Pancreatic fibrosis (HP:0100732)2.75560754
9Ectopic kidney (HP:0000086)2.74242100
10High anterior hairline (HP:0009890)2.73014895
11Cutaneous finger syndactyly (HP:0010554)2.71223065
12Reticulocytopenia (HP:0001896)2.60164028
13Pancreatic cysts (HP:0001737)2.58420488
14Nephronophthisis (HP:0000090)2.57307630
15Esophageal atresia (HP:0002032)2.53681727
16Cutaneous syndactyly (HP:0012725)2.43957868
17Molar tooth sign on MRI (HP:0002419)2.42595542
18Abnormality of midbrain morphology (HP:0002418)2.42595542
19Sclerocornea (HP:0000647)2.39937218
20Bifid tongue (HP:0010297)2.39346512
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.38215720
22Rib fusion (HP:0000902)2.34346863
23Hepatoblastoma (HP:0002884)2.34217541
24Partial duplication of thumb phalanx (HP:0009944)2.32392336
25Choanal stenosis (HP:0000452)2.32221262
26Hypoplastic ischia (HP:0003175)2.29493891
27Renal hypoplasia (HP:0000089)2.28902301
28Intestinal atresia (HP:0011100)2.27617654
29Preaxial hand polydactyly (HP:0001177)2.26776896
30Anencephaly (HP:0002323)2.25679084
31Abnormality of the pubic bones (HP:0003172)2.24790468
32Morphological abnormality of the middle ear (HP:0008609)2.24732154
33Aqueductal stenosis (HP:0002410)2.21847589
34Abnormality of the ischium (HP:0003174)2.21448757
35Absent radius (HP:0003974)2.20235682
36Cystic liver disease (HP:0006706)2.20139200
37Duplication of thumb phalanx (HP:0009942)2.18627011
38Progressive cerebellar ataxia (HP:0002073)2.17792818
39Abnormality of the renal medulla (HP:0100957)2.15478032
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14765880
41Triphalangeal thumb (HP:0001199)2.14137761
42Stenosis of the external auditory canal (HP:0000402)2.14133726
43Absent forearm bone (HP:0003953)2.13361882
44Aplasia involving forearm bones (HP:0009822)2.13361882
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09602228
46Absent septum pellucidum (HP:0001331)2.09144645
47Oligodactyly (hands) (HP:0001180)2.08053511
48Meckel diverticulum (HP:0002245)2.07115950
49Preaxial foot polydactyly (HP:0001841)2.06547153
50Abnormality of the diencephalon (HP:0010662)2.06238702
51Broad thumb (HP:0011304)2.06173444
52Patellar aplasia (HP:0006443)2.05726292
53Abnormality of the ileum (HP:0001549)2.04729020
54Gastrointestinal atresia (HP:0002589)2.04422674
55Oligodactyly (HP:0012165)2.04179912
56Trigonocephaly (HP:0000243)2.02726138
57Bicornuate uterus (HP:0000813)2.02350948
58Myelomeningocele (HP:0002475)2.01532124
59Vaginal atresia (HP:0000148)2.00642872
60Optic nerve hypoplasia (HP:0000609)1.99766857
61Chromsome breakage (HP:0040012)1.99034493
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97349422
63Labial hypoplasia (HP:0000066)1.97212393
64Vitreoretinal degeneration (HP:0000655)1.96353090
65Genital tract atresia (HP:0001827)1.95444142
66Maternal diabetes (HP:0009800)1.93666046
67Hypoplastic female external genitalia (HP:0012815)1.93496129
68Partial duplication of the phalanx of hand (HP:0009999)1.92766271
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.91144675
70Partial agenesis of the corpus callosum (HP:0001338)1.87251554
71Cupped ear (HP:0000378)1.87176860
72Postaxial foot polydactyly (HP:0001830)1.86957006
73Abnormal number of incisors (HP:0011064)1.86556240
74Aplasia/Hypoplasia of the patella (HP:0006498)1.86498453
75Optic nerve coloboma (HP:0000588)1.85576238
76Broad phalanges of the hand (HP:0009768)1.84330709
77Midline defect of the nose (HP:0004122)1.82716366
78Congenital stationary night blindness (HP:0007642)1.79759034
79Broad finger (HP:0001500)1.79352028
80Holoprosencephaly (HP:0001360)1.78113195
81Abnormality of cochlea (HP:0000375)1.76441023
82Tubular atrophy (HP:0000092)1.75917884
83Absent thumb (HP:0009777)1.75880418
84Abnormality of the septum pellucidum (HP:0007375)1.74529622
85Dandy-Walker malformation (HP:0001305)1.74399088
86Bronchomalacia (HP:0002780)1.74085329
87Facial cleft (HP:0002006)1.73692835
88Hypoplastic labia majora (HP:0000059)1.71835912
89Short 4th metacarpal (HP:0010044)1.71709813
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71709813
91Tracheomalacia (HP:0002779)1.70415302
92Abnormal lung lobation (HP:0002101)1.69537338
93Hemivertebrae (HP:0002937)1.69248442
94Hypoplasia of the ulna (HP:0003022)1.68867024
95Abnormality of the aortic arch (HP:0012303)1.68276029
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.68061024
97Postaxial hand polydactyly (HP:0001162)1.67866364
98Chronic hepatic failure (HP:0100626)1.67744754
99Broad phalanx (HP:0006009)1.67462612
100Morphological abnormality of the inner ear (HP:0011390)1.66604661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.42475716
2CDC73.11125071
3BMPR1B2.60790597
4TNIK2.36305394
5FRK2.35713099
6FGFR22.34449279
7CASK2.23396937
8MAPK152.21297464
9VRK22.13808455
10DYRK22.09407789
11PASK1.96105331
12MKNK21.92519762
13NUAK11.90689276
14LATS11.87871447
15WNK31.84037698
16PNCK1.83762423
17MKNK11.82107968
18NME11.74782741
19NEK21.72642296
20TAF11.70560421
21ZAK1.65308047
22MAP3K41.62757400
23GRK11.55438949
24EPHA41.52632360
25STK38L1.46428507
26EPHB21.42094108
27MAP3K101.36030705
28PLK41.35964113
29TSSK61.34586708
30VRK11.31390856
31TYRO31.25293131
32ADRBK21.24315195
33TTK1.21151201
34TGFBR11.20800557
35TRIM281.18743034
36WEE11.16906911
37CAMK1G1.14362660
38CAMK1D1.13732333
39BCR1.11134637
40ACVR1B1.10684996
41CDK191.10215789
42ATR1.08110664
43NTRK21.05342291
44PLK11.05028032
45PLK31.03436000
46PIK3CA1.02375778
47CHEK21.00425342
48WNK40.98842662
49SRPK10.98470749
50MAP2K70.98260888
51CSNK1G10.93707864
52FGFR10.91273735
53PRKCG0.90341360
54DYRK30.82395557
55OXSR10.81830061
56MAP4K20.80228589
57TLK10.78691369
58SIK20.76724533
59CSNK1G20.73986309
60MAPK130.72226829
61STK30.71376886
62ATM0.69185694
63ERBB20.69085078
64BCKDK0.68195303
65CSNK1G30.67874540
66TIE10.67329175
67NLK0.66736659
68BUB10.65029991
69PRKCE0.64872511
70NTRK30.63699751
71AURKB0.59435296
72PINK10.57640254
73BRSK20.57213166
74CSNK1A1L0.56189570
75DYRK1A0.55363911
76CSNK1E0.53645287
77CHEK10.53488625
78MARK10.52870656
79STK390.52810699
80MUSK0.51833245
81STK110.49542951
82CDK10.49490007
83CSNK1A10.46048781
84CDK20.45940271
85CAMK10.45373125
86PRKDC0.44620831
87CDK70.44457401
88CDK30.44017995
89PLK20.43007352
90MAPKAPK50.41363823
91AURKA0.41044027
92MAP3K70.39875731
93GSK3B0.39415604
94ADRBK10.38738250
95CDK80.38594907
96CSNK1D0.37922955
97RPS6KB20.35264422
98BMX0.34949784
99MTOR0.33993187
100SGK2230.33826320

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.23288464
2Fanconi anemia pathway_Homo sapiens_hsa034602.80742667
3Homologous recombination_Homo sapiens_hsa034402.57996465
4Hedgehog signaling pathway_Homo sapiens_hsa043402.52118828
5Mismatch repair_Homo sapiens_hsa034302.44909565
6DNA replication_Homo sapiens_hsa030302.39014984
7Nicotine addiction_Homo sapiens_hsa050332.19687930
8Ribosome_Homo sapiens_hsa030102.13719752
9Hippo signaling pathway_Homo sapiens_hsa043902.06799961
10Base excision repair_Homo sapiens_hsa034101.92987711
11RNA polymerase_Homo sapiens_hsa030201.91355437
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88590687
13Phototransduction_Homo sapiens_hsa047441.75760828
14Non-homologous end-joining_Homo sapiens_hsa034501.68863571
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68330533
16Lysine degradation_Homo sapiens_hsa003101.63661033
17Taste transduction_Homo sapiens_hsa047421.56981655
18Wnt signaling pathway_Homo sapiens_hsa043101.54015202
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53287291
20RNA degradation_Homo sapiens_hsa030181.50797375
21Spliceosome_Homo sapiens_hsa030401.46410191
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44692362
23Selenocompound metabolism_Homo sapiens_hsa004501.43090563
24RNA transport_Homo sapiens_hsa030131.42495974
25Basal transcription factors_Homo sapiens_hsa030221.42260316
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40050160
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39156390
28Huntingtons disease_Homo sapiens_hsa050161.36738721
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35966505
30Nucleotide excision repair_Homo sapiens_hsa034201.35555587
31Axon guidance_Homo sapiens_hsa043601.29979416
32Steroid biosynthesis_Homo sapiens_hsa001001.29912213
33mRNA surveillance pathway_Homo sapiens_hsa030151.21590972
34Oxidative phosphorylation_Homo sapiens_hsa001901.19281591
35Butanoate metabolism_Homo sapiens_hsa006501.19234896
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17591436
37One carbon pool by folate_Homo sapiens_hsa006701.17190690
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16257829
39Notch signaling pathway_Homo sapiens_hsa043301.15016358
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14496189
41Melanogenesis_Homo sapiens_hsa049161.13169682
42Cell cycle_Homo sapiens_hsa041101.12781335
43Cardiac muscle contraction_Homo sapiens_hsa042601.12684030
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.10936577
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10394653
46Parkinsons disease_Homo sapiens_hsa050121.08082381
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05801681
48Linoleic acid metabolism_Homo sapiens_hsa005911.05524812
49Nitrogen metabolism_Homo sapiens_hsa009100.99825020
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97737580
51Tight junction_Homo sapiens_hsa045300.97594984
52Sulfur relay system_Homo sapiens_hsa041220.92009460
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91602498
54Morphine addiction_Homo sapiens_hsa050320.91173772
55TGF-beta signaling pathway_Homo sapiens_hsa043500.89476526
56Glutamatergic synapse_Homo sapiens_hsa047240.88663590
57Pyrimidine metabolism_Homo sapiens_hsa002400.88610556
58Olfactory transduction_Homo sapiens_hsa047400.87918530
59Tryptophan metabolism_Homo sapiens_hsa003800.87595159
60Purine metabolism_Homo sapiens_hsa002300.86105836
61GABAergic synapse_Homo sapiens_hsa047270.85922672
62Ether lipid metabolism_Homo sapiens_hsa005650.83632521
63Propanoate metabolism_Homo sapiens_hsa006400.81886482
64Adherens junction_Homo sapiens_hsa045200.81741275
65Protein export_Homo sapiens_hsa030600.81332698
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79441513
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79408133
68Insulin secretion_Homo sapiens_hsa049110.74094257
69Serotonergic synapse_Homo sapiens_hsa047260.68125204
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67698411
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60764082
72Circadian entrainment_Homo sapiens_hsa047130.60434943
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.56923027
74Cocaine addiction_Homo sapiens_hsa050300.56653156
75p53 signaling pathway_Homo sapiens_hsa041150.54965724
76Alzheimers disease_Homo sapiens_hsa050100.54795274
77Retinol metabolism_Homo sapiens_hsa008300.53880418
78Peroxisome_Homo sapiens_hsa041460.53574115
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52292236
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52119848
81Vitamin digestion and absorption_Homo sapiens_hsa049770.49987060
82Metabolic pathways_Homo sapiens_hsa011000.49320284
83Caffeine metabolism_Homo sapiens_hsa002320.48739968
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48163763
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48124582
86Dopaminergic synapse_Homo sapiens_hsa047280.47794350
87Folate biosynthesis_Homo sapiens_hsa007900.45675475
88Oocyte meiosis_Homo sapiens_hsa041140.45431100
89MicroRNAs in cancer_Homo sapiens_hsa052060.44710498
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42667089
91Thyroid hormone synthesis_Homo sapiens_hsa049180.41378559
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41213544
93Ovarian steroidogenesis_Homo sapiens_hsa049130.41194048
94beta-Alanine metabolism_Homo sapiens_hsa004100.41151189
95Cholinergic synapse_Homo sapiens_hsa047250.41075900
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40735465
97Protein digestion and absorption_Homo sapiens_hsa049740.37548016
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.37509289
99Pathways in cancer_Homo sapiens_hsa052000.36867059
100Alcoholism_Homo sapiens_hsa050340.35337486

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