PLEKHG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.34847783
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21374421
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.00583055
4locomotory exploration behavior (GO:0035641)4.94150714
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79821989
6hemidesmosome assembly (GO:0031581)4.70679594
7glutamate secretion (GO:0014047)4.37701764
8positive regulation of synapse maturation (GO:0090129)4.36871850
9vocalization behavior (GO:0071625)4.36374761
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32386395
11regulation of glutamate receptor signaling pathway (GO:1900449)4.30358657
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23798009
13regulation of neuronal synaptic plasticity (GO:0048168)4.15113769
14synaptic vesicle exocytosis (GO:0016079)4.10010516
15regulation of synapse structural plasticity (GO:0051823)4.04684823
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.98451703
17regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81385774
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75834321
19signal complex assembly (GO:0007172)3.74512755
20proline transport (GO:0015824)3.67680726
21positive regulation of fibroblast migration (GO:0010763)3.64919042
22desmosome organization (GO:0002934)3.64713601
23protein localization to synapse (GO:0035418)3.60647948
24exploration behavior (GO:0035640)3.58309813
25cerebellar granule cell differentiation (GO:0021707)3.57350908
26gonadal mesoderm development (GO:0007506)3.54113717
27cell communication by electrical coupling (GO:0010644)3.53813300
28regulation of dendritic spine morphogenesis (GO:0061001)3.49436471
29regulation of synaptic plasticity (GO:0048167)3.48615092
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45205996
31G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44774963
32synaptic transmission, glutamatergic (GO:0035249)3.44153251
33glutamate receptor signaling pathway (GO:0007215)3.43361964
34neuronal ion channel clustering (GO:0045161)3.42922707
35neuromuscular process controlling balance (GO:0050885)3.38016003
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35377604
37postsynaptic membrane organization (GO:0001941)3.34633497
38dendritic spine organization (GO:0097061)3.31669756
39dendritic spine morphogenesis (GO:0060997)3.30725148
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.29670002
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29424652
42establishment of nucleus localization (GO:0040023)3.29370751
43long-term memory (GO:0007616)3.24336992
44regulation of synaptic vesicle exocytosis (GO:2000300)3.21692535
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.21013432
46semaphorin-plexin signaling pathway (GO:0071526)3.18642536
47regulation of synaptic vesicle transport (GO:1902803)3.17645979
48regulation of synapse maturation (GO:0090128)3.16441085
49synaptic vesicle endocytosis (GO:0048488)3.16027313
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15131246
51cell migration in hindbrain (GO:0021535)3.10921971
52stress fiber assembly (GO:0043149)3.10890899
53neurotransmitter-gated ion channel clustering (GO:0072578)3.08569037
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08419967
55regulation of postsynaptic membrane potential (GO:0060078)3.08118886
56sodium ion export (GO:0071436)3.07174670
57neuronal action potential propagation (GO:0019227)3.07173365
58neuromuscular process controlling posture (GO:0050884)3.06936739
59layer formation in cerebral cortex (GO:0021819)3.05627482
60activation of protein kinase A activity (GO:0034199)3.05084383
61activation of Rac GTPase activity (GO:0032863)3.02593139
62plasma membrane repair (GO:0001778)3.01515953
63behavioral fear response (GO:0001662)2.93056779
64behavioral defense response (GO:0002209)2.93056779
65neurotransmitter secretion (GO:0007269)2.91580829
66long term synaptic depression (GO:0060292)2.90207232
67neuron-neuron synaptic transmission (GO:0007270)2.90198746
68positive regulation of dendritic spine development (GO:0060999)2.88026990
69negative regulation of catenin import into nucleus (GO:0035414)2.87849751
70negative regulation of potassium ion transmembrane transport (GO:1901380)2.87848778
71calcium-mediated signaling using intracellular calcium source (GO:0035584)2.87705117
72cell-substrate junction assembly (GO:0007044)2.87074658
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84166171
74cellular potassium ion homeostasis (GO:0030007)2.81205192
75positive regulation of membrane potential (GO:0045838)2.79838005
76ephrin receptor signaling pathway (GO:0048013)2.79557572
77adherens junction assembly (GO:0034333)2.79395376
78cellular sodium ion homeostasis (GO:0006883)2.79214932
79regulation of clathrin-mediated endocytosis (GO:2000369)2.78043478
80regulation of axon extension involved in axon guidance (GO:0048841)2.77507391
81long-term synaptic potentiation (GO:0060291)2.76915758
82regulation of dendritic spine development (GO:0060998)2.74667576
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72596062
84auditory behavior (GO:0031223)2.71941663
85chemosensory behavior (GO:0007635)2.70587429
86cell-substrate adherens junction assembly (GO:0007045)2.70296930
87focal adhesion assembly (GO:0048041)2.70296930
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67161580
89neuromuscular process (GO:0050905)2.66697403
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66475243
91peripheral nervous system axon ensheathment (GO:0032292)2.65767121
92myelination in peripheral nervous system (GO:0022011)2.65767121
93lung epithelium development (GO:0060428)2.65342191
94positive regulation of dendrite morphogenesis (GO:0050775)2.64845015
95cell communication involved in cardiac conduction (GO:0086065)2.64400736
96fear response (GO:0042596)2.63768940
97negative regulation of amino acid transport (GO:0051956)2.63487489
98regulation of ARF GTPase activity (GO:0032312)2.63433454
99negative regulation of chondrocyte differentiation (GO:0032331)2.63186611
100camera-type eye morphogenesis (GO:0048593)2.62541447
101innervation (GO:0060384)2.61630981
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.61005658
103mating behavior (GO:0007617)2.60925838
104regulation of Rap GTPase activity (GO:0032317)2.60796625
105positive regulation of dendrite development (GO:1900006)2.59190253
106neuron recognition (GO:0008038)2.58810126
107axon extension (GO:0048675)2.58792989
108histone H4-K12 acetylation (GO:0043983)2.56799015
109serotonin metabolic process (GO:0042428)2.54498633
110positive regulation of neurotransmitter secretion (GO:0001956)2.54483861
111axonal fasciculation (GO:0007413)2.53556576
112regulation of axon guidance (GO:1902667)2.53447819
113cerebellar Purkinje cell differentiation (GO:0021702)2.51872093
114membrane depolarization (GO:0051899)2.49485308
115regulation of ion transmembrane transporter activity (GO:0032412)2.46616541
116negative regulation of potassium ion transport (GO:0043267)2.45068770
117axon extension involved in axon guidance (GO:0048846)2.44998551
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.44998551
119apical protein localization (GO:0045176)2.44760702
120negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.44161172
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44142894
122membrane depolarization during action potential (GO:0086010)2.43808168
123cardiac myofibril assembly (GO:0055003)2.43791432
124establishment of tissue polarity (GO:0007164)2.41060062
125establishment of planar polarity (GO:0001736)2.41060062
126regulation of synaptic transmission (GO:0050804)2.40990741
127neural tube development (GO:0021915)2.38544342
128lateral sprouting from an epithelium (GO:0060601)2.36729133
129neuron projection extension (GO:1990138)2.36536761
130amino acid import (GO:0043090)2.36504427
131neurotransmitter transport (GO:0006836)2.35699679
132cell-cell junction maintenance (GO:0045217)2.35311610
133neuron remodeling (GO:0016322)2.33617803
134keratinocyte proliferation (GO:0043616)2.32848522
135central nervous system myelination (GO:0022010)2.32566089
136axon ensheathment in central nervous system (GO:0032291)2.32566089
137establishment of skin barrier (GO:0061436)2.32501960
138positive regulation of synapse assembly (GO:0051965)2.30120637
139neuromuscular junction development (GO:0007528)2.28873439
140regulation of ARF protein signal transduction (GO:0032012)2.28403586
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27832030
142response to auditory stimulus (GO:0010996)2.26202661
143collecting duct development (GO:0072044)2.23662695
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.22040033
145regulation of vesicle fusion (GO:0031338)2.21744381
146retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21500172
147developmental cell growth (GO:0048588)2.21330742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.75476422
2EZH2_22144423_ChIP-Seq_EOC_Human4.74375832
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.05609378
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.95003674
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.82920438
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53478818
7* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50187654
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44459755
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44459755
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44459755
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40815454
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.33300837
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17845123
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17845123
15* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11036589
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10678401
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10641302
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08942230
19DROSHA_22980978_ChIP-Seq_HELA_Human2.08809287
20* KDM2B_26808549_Chip-Seq_K562_Human2.07572517
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06479844
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04914374
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98697151
24REST_21632747_ChIP-Seq_MESCs_Mouse1.95979751
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95787039
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95020321
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92906431
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91468640
29* LXR_22292898_ChIP-Seq_THP-1_Human1.81945024
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80662034
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.79936785
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.76372403
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75942203
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75614224
35* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74687936
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73599163
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.73476022
38ZNF263_19887448_ChIP-Seq_K562_Human1.72846194
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68381562
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66160350
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65439780
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65329615
43* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.64020543
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63609158
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61848121
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61801499
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61285954
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58516139
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57606409
50* KDM2B_26808549_Chip-Seq_DND41_Human1.56114614
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.55581577
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53037933
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51646330
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.49026431
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47705811
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46943915
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.46519458
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43297206
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42711931
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41861843
61* CTCF_27219007_Chip-Seq_Bcells_Human1.41700181
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.40756438
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40568167
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40526069
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40070595
66* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39757397
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38973322
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.34375833
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33815771
70* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32028457
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31362496
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29999183
73SMC4_20622854_ChIP-Seq_HELA_Human1.29923152
74TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27449544
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.26472269
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.25664845
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.25642708
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.24257018
79CREB1_26743006_Chip-Seq_LNCaP_Human1.23009834
80GBX2_23144817_ChIP-Seq_PC3_Human1.21920813
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20233447
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19237967
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18671896
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18106906
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16704153
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14311684
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12425776
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.10116093
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10058763
90* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08335940
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08026757
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.07294651
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05312021
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.04508556
95OCT4_19829295_ChIP-Seq_ESCs_Human1.04362732
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03643235
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02499556
98* TCF7_22412390_ChIP-Seq_EML_Mouse1.01958775
99* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00723193
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00096251
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.99464518
102AHR_22903824_ChIP-Seq_MCF-7_Human0.99452604
103AR_19668381_ChIP-Seq_PC3_Human0.99328647
104* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99273719
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97369481
106TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97314072
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.97078087
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.95941318
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95789751
110KLF4_19829295_ChIP-Seq_ESCs_Human0.95137959
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94306995
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94181552
113* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93224091
114P68_20966046_ChIP-Seq_HELA_Human0.92914413
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92008561
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91673137
117TP53_22127205_ChIP-Seq_IMR90_Human0.90779297
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90562508
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.90470432
120CBX2_27304074_Chip-Seq_ESCs_Mouse0.88869748
121* TP63_22573176_ChIP-Seq_HFKS_Human0.88183962
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87933985
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87784562
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.87690932
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.87513779
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82539913
127CLOCK_20551151_ChIP-Seq_293T_Human0.82030232
128* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78822477
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78599554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09013149
2MP0003635_abnormal_synaptic_transmissio3.45711392
3MP0003880_abnormal_central_pattern3.29739286
4MP0000579_abnormal_nail_morphology3.15947252
5MP0002063_abnormal_learning/memory/cond2.83050085
6MP0000566_synostosis2.78066598
7MP0000751_myopathy2.77460621
8MP0004270_analgesia2.64444383
9MP0004858_abnormal_nervous_system2.49824229
10MP0009745_abnormal_behavioral_response2.40375034
11MP0005423_abnormal_somatic_nervous2.37084137
12MP0002064_seizures2.27287828
13MP0010030_abnormal_orbit_morphology2.19496646
14MP0005409_darkened_coat_color2.14259820
15MP0002572_abnormal_emotion/affect_behav2.11324171
16MP0002822_catalepsy1.94290996
17MP0009780_abnormal_chondrocyte_physiolo1.93336842
18MP0003283_abnormal_digestive_organ1.91130829
19MP0002837_dystrophic_cardiac_calcinosis1.81118278
20MP0001501_abnormal_sleep_pattern1.81035854
21MP0008438_abnormal_cutaneous_collagen1.76916207
22MP0003705_abnormal_hypodermis_morpholog1.75599444
23MP0001440_abnormal_grooming_behavior1.73620363
24MP0003879_abnormal_hair_cell1.73400856
25MP0004215_abnormal_myocardial_fiber1.73131298
26MP0005623_abnormal_meninges_morphology1.71810804
27MP0009046_muscle_twitch1.65318714
28MP0000762_abnormal_tongue_morphology1.64910517
29MP0008961_abnormal_basal_metabolism1.64754083
30MP0002272_abnormal_nervous_system1.62275338
31MP0001486_abnormal_startle_reflex1.59233605
32MP0005257_abnormal_intraocular_pressure1.55139996
33MP0003787_abnormal_imprinting1.53774636
34MP0004084_abnormal_cardiac_muscle1.49894485
35MP0004145_abnormal_muscle_electrophysio1.49738362
36MP0002909_abnormal_adrenal_gland1.49301051
37MP0001299_abnormal_eye_distance/1.48801360
38MP0002653_abnormal_ependyma_morphology1.47248681
39MP0000537_abnormal_urethra_morphology1.46907669
40MP0004233_abnormal_muscle_weight1.45812524
41MP0005330_cardiomyopathy1.45729602
42MP0004885_abnormal_endolymph1.45723094
43MP0002269_muscular_atrophy1.44182327
44MP0010234_abnormal_vibrissa_follicle1.43529949
45MP0005503_abnormal_tendon_morphology1.40269142
46MP0003137_abnormal_impulse_conducting1.39142059
47MP0000749_muscle_degeneration1.35589234
48MP0001502_abnormal_circadian_rhythm1.35148969
49MP0003075_altered_response_to1.33658088
50MP0001968_abnormal_touch/_nociception1.32082201
51MP0004811_abnormal_neuron_physiology1.31853755
52MP0004087_abnormal_muscle_fiber1.29421795
53MP0001958_emphysema1.22263741
54MP0003119_abnormal_digestive_system1.21717886
55MP0003123_paternal_imprinting1.21704092
56MP0005167_abnormal_blood-brain_barrier1.21682462
57MP0001348_abnormal_lacrimal_gland1.20876089
58MP0000467_abnormal_esophagus_morphology1.20671081
59MP0003279_aneurysm1.20449083
60MP0008569_lethality_at_weaning1.19616882
61MP0000955_abnormal_spinal_cord1.17056347
62MP0000750_abnormal_muscle_regeneration1.17039602
63MP0004085_abnormal_heartbeat1.16180906
64MP0006138_congestive_heart_failure1.15968391
65MP0002734_abnormal_mechanical_nocicepti1.15806308
66MP0000747_muscle_weakness1.15260625
67MP0002234_abnormal_pharynx_morphology1.15073416
68MP0003122_maternal_imprinting1.14896710
69MP0002332_abnormal_exercise_endurance1.14300362
70MP0002733_abnormal_thermal_nociception1.13958622
71MP0001879_abnormal_lymphatic_vessel1.13586601
72MP0002735_abnormal_chemical_nociception1.13326869
73MP0003329_amyloid_beta_deposits1.11773038
74MP0000678_abnormal_parathyroid_gland1.10518344
75MP0000759_abnormal_skeletal_muscle1.10333700
76MP0005670_abnormal_white_adipose1.09016486
77MP0003828_pulmonary_edema1.07991006
78MP0000013_abnormal_adipose_tissue1.07754520
79MP0002106_abnormal_muscle_physiology1.06943805
80MP0004272_abnormal_basement_membrane1.06719859
81MP0003045_fibrosis1.03727848
82MP0001970_abnormal_pain_threshold1.02855925
83MP0002060_abnormal_skin_morphology1.02162040
84MP0004185_abnormal_adipocyte_glucose1.01777359
85MP0004133_heterotaxia1.01759006
86MP0010368_abnormal_lymphatic_system1.01719682
87MP0002089_abnormal_postnatal_growth/wei1.00898093
88MP0000003_abnormal_adipose_tissue1.00627953
89MP0002184_abnormal_innervation1.00476264
90MP0004484_altered_response_of0.98239290
91MP0009053_abnormal_anal_canal0.97707788
92MP0005369_muscle_phenotype0.97132609
93MP0002066_abnormal_motor_capabilities/c0.96025793
94MP0000778_abnormal_nervous_system0.94971891
95MP0002067_abnormal_sensory_capabilities0.94918330
96MP0002882_abnormal_neuron_morphology0.94356420
97MP0005620_abnormal_muscle_contractility0.92596961
98MP0004130_abnormal_muscle_cell0.91558857
99MP0006292_abnormal_olfactory_placode0.91479056
100MP0003385_abnormal_body_wall0.91251274
101MP0003634_abnormal_glial_cell0.90967698
102MP0004036_abnormal_muscle_relaxation0.90637168
103MP0003633_abnormal_nervous_system0.90353087
104MP0008770_decreased_survivor_rate0.90265590
105MP0002736_abnormal_nociception_after0.89836217
106MP0000534_abnormal_ureter_morphology0.89008147
107MP0010630_abnormal_cardiac_muscle0.88333501
108MP0001346_abnormal_lacrimal_gland0.87635996
109MP0002127_abnormal_cardiovascular_syste0.87462131
110MP0002249_abnormal_larynx_morphology0.87052972
111MP0005501_abnormal_skin_physiology0.86880360
112MP0004264_abnormal_extraembryonic_tissu0.86337233
113MP0005171_absent_coat_pigmentation0.85337797
114MP0006276_abnormal_autonomic_nervous0.83994915
115MP0001849_ear_inflammation0.82936966
116MP0001177_atelectasis0.82689339
117MP0010771_integument_phenotype0.82414400
118MP0000026_abnormal_inner_ear0.82044734
119MP0000733_abnormal_muscle_development0.81874713
120MP0003453_abnormal_keratinocyte_physiol0.81794525
121MP0002896_abnormal_bone_mineralization0.81585236
122MP0002108_abnormal_muscle_morphology0.81475579
123MP0001188_hyperpigmentation0.81429269
124MP0002152_abnormal_brain_morphology0.80869079
125MP0003091_abnormal_cell_migration0.79579795
126MP0005076_abnormal_cell_differentiation0.79160662
127MP0000049_abnormal_middle_ear0.78725512
128MP0005508_abnormal_skeleton_morphology0.78186121
129MP0002557_abnormal_social/conspecific_i0.78059968
130MP0000462_abnormal_digestive_system0.76887041
131MP0008874_decreased_physiological_sensi0.76095654
132MP0009379_abnormal_foot_pigmentation0.75739757
133MP0003941_abnormal_skin_development0.75067127
134MP0002116_abnormal_craniofacial_bone0.73873371
135MP0003566_abnormal_cell_adhesion0.73662463
136MP0005595_abnormal_vascular_smooth0.73439350
137MP0005275_abnormal_skin_tensile0.73374313
138MP0003646_muscle_fatigue0.72209617
139MP0003755_abnormal_palate_morphology0.72142220
140MP0005666_abnormal_adipose_tissue0.70936135
141MP0003861_abnormal_nervous_system0.70346175
142MP0002796_impaired_skin_barrier0.69415602
143MP0005377_hearing/vestibular/ear_phenot0.66491794
144MP0003878_abnormal_ear_physiology0.66491794

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.92775836
2Myokymia (HP:0002411)4.79511915
3Atrophic scars (HP:0001075)4.25897416
4Focal seizures (HP:0007359)4.04641306
5Annular pancreas (HP:0001734)3.34198913
6Atonic seizures (HP:0010819)3.24365937
7Visual hallucinations (HP:0002367)3.23362072
8Epileptic encephalopathy (HP:0200134)3.22224090
9Increased connective tissue (HP:0009025)3.16135280
10Amblyopia (HP:0000646)3.15148510
11Neurofibrillary tangles (HP:0002185)3.05046185
12Premature rupture of membranes (HP:0001788)3.01668109
13Fragile skin (HP:0001030)2.97819733
14Sudden death (HP:0001699)2.97112936
15Febrile seizures (HP:0002373)2.97016904
16Aplasia involving bones of the extremities (HP:0009825)2.94318389
17Aplasia involving bones of the upper limbs (HP:0009823)2.94318389
18Aplasia of the phalanges of the hand (HP:0009802)2.94318389
19Ventricular fibrillation (HP:0001663)2.92324903
20Difficulty running (HP:0009046)2.86637476
21Milia (HP:0001056)2.85289427
22Fragile nails (HP:0001808)2.85188476
23Cerebral aneurysm (HP:0004944)2.84315078
24* Abnormality of the lower motor neuron (HP:0002366)2.82097424
25Achilles tendon contracture (HP:0001771)2.80901462
26Testicular atrophy (HP:0000029)2.76523763
27Bundle branch block (HP:0011710)2.72992179
28Neonatal short-limb short stature (HP:0008921)2.68297170
29Dialeptic seizures (HP:0011146)2.67317487
30Arterial tortuosity (HP:0005116)2.59667939
31Absence seizures (HP:0002121)2.58443420
32Abnormality of binocular vision (HP:0011514)2.54714431
33Diplopia (HP:0000651)2.54714431
34Abnormality of nail color (HP:0100643)2.53424778
35Increased variability in muscle fiber diameter (HP:0003557)2.50620996
36Upper limb amyotrophy (HP:0009129)2.49393321
37Distal upper limb amyotrophy (HP:0007149)2.49393321
38Dysmetric saccades (HP:0000641)2.48372751
39Abnormality of the Achilles tendon (HP:0005109)2.47137209
40Bladder diverticulum (HP:0000015)2.44079609
41Vascular tortuosity (HP:0004948)2.43383698
42Cerebral inclusion bodies (HP:0100314)2.42722496
43Pterygium (HP:0001059)2.40871472
44Lower limb amyotrophy (HP:0007210)2.39413968
45Hyperacusis (HP:0010780)2.38338543
46Ependymoma (HP:0002888)2.38043332
47Action tremor (HP:0002345)2.33343086
48Generalized tonic-clonic seizures (HP:0002069)2.32308478
49Distal lower limb amyotrophy (HP:0008944)2.30247299
50Exercise-induced myalgia (HP:0003738)2.24020293
51Plantar hyperkeratosis (HP:0007556)2.23613464
52Rib fusion (HP:0000902)2.22762587
53Abnormality of the astrocytes (HP:0100707)2.21973376
54Astrocytoma (HP:0009592)2.21973376
55Fetal akinesia sequence (HP:0001989)2.21814893
56Pointed chin (HP:0000307)2.20878626
57Dysdiadochokinesis (HP:0002075)2.19454626
58Ventricular arrhythmia (HP:0004308)2.16367670
59Abnormality of skeletal muscle fiber size (HP:0012084)2.14233623
60Urethral obstruction (HP:0000796)2.13460770
61Turricephaly (HP:0000262)2.09450399
62Thick nail (HP:0001805)2.07283223
63Obstructive sleep apnea (HP:0002870)2.06784597
64Coronal craniosynostosis (HP:0004440)2.06376810
65Thin ribs (HP:0000883)2.06157244
66Muscle fiber splitting (HP:0003555)2.06106256
67Type 1 muscle fiber predominance (HP:0003803)2.03914881
68Syncope (HP:0001279)2.03747874
69Neoplasm of the heart (HP:0100544)2.03335218
70Hip contracture (HP:0003273)2.02078188
71Impaired social interactions (HP:0000735)2.01723256
72Abnormal social behavior (HP:0012433)2.01723256
73Poor eye contact (HP:0000817)2.00920018
74Depression (HP:0000716)2.00510503
75Primary atrial arrhythmia (HP:0001692)1.99341477
76Resting tremor (HP:0002322)1.98151220
77Shallow orbits (HP:0000586)1.97199153
78Hemiplegia (HP:0002301)1.96319756
79Hand muscle atrophy (HP:0009130)1.96070541
80Impaired vibration sensation in the lower limbs (HP:0002166)1.95953735
81Broad face (HP:0000283)1.94601834
82Atrial fibrillation (HP:0005110)1.94419821
83Dysmetria (HP:0001310)1.94092613
84Supraventricular arrhythmia (HP:0005115)1.92814966
85* Difficulty climbing stairs (HP:0003551)1.91787535
86Onycholysis (HP:0001806)1.91733142
87Genetic anticipation (HP:0003743)1.91306559
88Postural instability (HP:0002172)1.89869455
89Truncal ataxia (HP:0002078)1.89807565
90Progressive cerebellar ataxia (HP:0002073)1.88941331
91Shawl scrotum (HP:0000049)1.88446039
92* Mildly elevated creatine phosphokinase (HP:0008180)1.88310123
93Abnormal EKG (HP:0003115)1.88086743
94Supraventricular tachycardia (HP:0004755)1.87871918
95Sleep apnea (HP:0010535)1.86513275
96Bowel diverticulosis (HP:0005222)1.83952246
97Impaired smooth pursuit (HP:0007772)1.83118758
98Hypoplasia of the iris (HP:0007676)1.82884078
99Abnormality of the calf musculature (HP:0001430)1.82323182
100Ankle contracture (HP:0006466)1.82052756
101Cervical subluxation (HP:0003308)1.81732636
102Spinal rigidity (HP:0003306)1.81544790
103Myotonia (HP:0002486)1.80236884
104Short humerus (HP:0005792)1.79481267
105Wormian bones (HP:0002645)1.78977581
106Mitral valve prolapse (HP:0001634)1.78907438
107Ankle clonus (HP:0011448)1.78877805
108Ulnar bowing (HP:0003031)1.78780701
109Right ventricular cardiomyopathy (HP:0011663)1.78512832
110Vertebral arch anomaly (HP:0008438)1.78025909
111Overgrowth (HP:0001548)1.77498698
112Laryngomalacia (HP:0001601)1.76905239
113Congenital hip dislocation (HP:0001374)1.75716233
114Insomnia (HP:0100785)1.75689855
115Aortic dissection (HP:0002647)1.75077356
116Torticollis (HP:0000473)1.74792480
117Akinesia (HP:0002304)1.73148167
118Supranuclear gaze palsy (HP:0000605)1.72590681
119Protrusio acetabuli (HP:0003179)1.72585812
120Ankyloglossia (HP:0010296)1.72349643
121Hyporeflexia of lower limbs (HP:0002600)1.71997075
122Abnormal atrioventricular conduction (HP:0005150)1.71490485
123Bronchomalacia (HP:0002780)1.71194720
124Lymphangioma (HP:0100764)1.70987145
125Hyperventilation (HP:0002883)1.70576113
126Palmoplantar hyperkeratosis (HP:0000972)1.70527076
127Mitral regurgitation (HP:0001653)1.69322305
128Ventricular tachycardia (HP:0004756)1.69310934
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69194671
130Mild short stature (HP:0003502)1.69035075
131Hyperextensible skin (HP:0000974)1.68685827
132Nail dystrophy (HP:0008404)1.68655225
133Natal tooth (HP:0000695)1.68103215
134Abnormality of the aortic arch (HP:0012303)1.67561123
135Hemiparesis (HP:0001269)1.67497756
136Heart block (HP:0012722)1.67411944
137Atrioventricular block (HP:0001678)1.66846644
138EMG: myopathic abnormalities (HP:0003458)1.66671328
139Abnormality of dentin (HP:0010299)1.66454686
140Decreased circulating renin level (HP:0003351)1.66214937
141Genu recurvatum (HP:0002816)1.66112698
142Hypoventilation (HP:0002791)1.66055580
143Bilateral microphthalmos (HP:0007633)1.65913003
144Advanced eruption of teeth (HP:0006288)1.65607696
145Soft skin (HP:0000977)1.65374989
146Hyperactive renin-angiotensin system (HP:0000841)1.64735934
147Morphological abnormality of the middle ear (HP:0008609)1.64682472
148Broad metatarsal (HP:0001783)1.63250996
149Biconcave vertebral bodies (HP:0004586)1.63176607
150Popliteal pterygium (HP:0009756)1.62521539
151Alopecia of scalp (HP:0002293)1.61648997
152Status epilepticus (HP:0002133)1.61274358
153Ectopia lentis (HP:0001083)1.61247098
154Hypotrichosis (HP:0001006)1.60915325
155Aplasia/hypoplasia of the humerus (HP:0006507)1.60042223
156Abnormality of ocular smooth pursuit (HP:0000617)1.59584939
157Hypoplasia of dental enamel (HP:0006297)1.59472296
158Abnormal eating behavior (HP:0100738)1.58446197
159Thin bony cortex (HP:0002753)1.58341802
160Abnormality of the ischium (HP:0003174)1.56836351
161Limited hip movement (HP:0008800)1.56464303
162Palmar hyperkeratosis (HP:0010765)1.56240995
163Tracheomalacia (HP:0002779)1.55498685
164Acanthosis nigricans (HP:0000956)1.55018975
165Cutaneous finger syndactyly (HP:0010554)1.54650735
166Arnold-Chiari malformation (HP:0002308)1.53989092
167Spinal canal stenosis (HP:0003416)1.52746198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.82297578
2NTRK34.24711982
3MAP3K93.51842894
4MARK12.95327075
5PRKD32.79847133
6EPHB22.72614819
7DDR22.31861532
8KSR22.29111445
9TYRO32.20409955
10CDK122.18365381
11DAPK22.11829805
12SIK12.09244292
13DAPK12.08122829
14EPHA22.08042671
15MST1R1.97996403
16PAK61.93269865
17MET1.90079463
18GRK51.84738373
19STK381.77402866
20ICK1.72678882
21PTK2B1.65717826
22LATS21.63491701
23RIPK11.63463191
24CASK1.63067608
25TRIB31.53735916
26MINK11.48617026
27PRPF4B1.44513094
28MAP3K41.41400389
29EEF2K1.39707634
30KSR11.33926207
31PDGFRA1.32891023
32AKT31.32057407
33NTRK11.30788092
34MARK21.28458815
35NTRK21.24102534
36CAMKK11.20201550
37NEK11.18308000
38SIK21.16180968
39FGFR21.14441377
40TAOK11.12748571
41MAP3K71.10853372
42PRKD21.07694394
43MAP2K41.07349179
44CDK51.05811836
45RAF11.05810315
46PINK11.05471726
47LMTK21.04687696
48CAMK11.04041344
49SGK4941.02961672
50SGK2231.02961672
51ALK1.00233269
52RPS6KA20.99908203
53RIPK40.98826097
54ARAF0.98004648
55FER0.96597136
56BMX0.95141982
57MAPK150.93363696
58CAMK40.92415486
59MOS0.89739880
60DMPK0.89364221
61MAP3K60.87251614
62MAP3K130.85984800
63MATK0.82769163
64ROCK20.82652925
65WNK10.81702744
66CDC42BPA0.81538716
67FGR0.81130740
68INSRR0.80349321
69UHMK10.79655038
70PKN20.76912802
71TIE10.76594128
72PHKG20.76069416
73PHKG10.76069416
74MAP3K20.75633530
75GRK60.75580865
76PRKCG0.75564004
77PDK40.73781429
78PDK30.73781429
79EPHB10.71505796
80PDGFRB0.71212864
81TESK10.69058065
82CAMK2A0.68925769
83PLK20.68141803
84CDK150.68037618
85MUSK0.66917747
86CDK180.64887780
87ERBB20.64606598
88ROCK10.64343010
89PTK60.64125391
90SGK30.63907973
91PTK20.63511430
92PRKCH0.63421851
93TTN0.62706481
94CDK11A0.61986417
95PAK30.61844225
96MAPK70.60259383
97PAK20.60079018
98FGFR40.59718358
99PAK40.59466254
100CAMK2G0.57940244
101MAPKAPK30.57635559
102MAP3K110.57001954
103CDK140.56313650
104PNCK0.56186917
105PDK10.55267279
106NME10.55148337
107STK110.54915810
108MAP2K10.54109686
109PDPK10.53842717
110SGK20.53234911
111RPS6KA30.51468671
112SGK10.50513447
113DYRK1A0.49959219
114FES0.49918889
115MTOR0.48677454
116LATS10.48660681
117CAMK1G0.48593616
118MAP3K10.47534038
119MAP3K100.47408776
120MAPK100.47378347
121NEK60.46374739
122DAPK30.41712102
123CAMK2B0.41585648
124CSNK1E0.41428155
125PRKG20.41385935
126CDK190.40992076
127MAPK120.40251913
128SRC0.39678798
129SMG10.39628625
130MAP2K70.38939072
131DYRK1B0.37377506
132PDK20.36780238
133MAPK80.36013877
134FGFR10.35266351
135PRKAA10.34547951
136TAOK20.31948846
137RET0.31546463

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.69898877
2Nicotine addiction_Homo sapiens_hsa050332.55731438
3Circadian entrainment_Homo sapiens_hsa047132.42100278
4Synaptic vesicle cycle_Homo sapiens_hsa047212.28745060
5Amphetamine addiction_Homo sapiens_hsa050312.27387342
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25442706
7Glutamatergic synapse_Homo sapiens_hsa047242.12336528
8Olfactory transduction_Homo sapiens_hsa047402.11050484
9Salivary secretion_Homo sapiens_hsa049701.96267871
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90800199
11Oxytocin signaling pathway_Homo sapiens_hsa049211.86124820
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81896108
13GABAergic synapse_Homo sapiens_hsa047271.80778822
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78837951
15Gastric acid secretion_Homo sapiens_hsa049711.71549213
16Calcium signaling pathway_Homo sapiens_hsa040201.68324634
17GnRH signaling pathway_Homo sapiens_hsa049121.68032908
18Morphine addiction_Homo sapiens_hsa050321.64831421
19Dopaminergic synapse_Homo sapiens_hsa047281.62065905
20Insulin secretion_Homo sapiens_hsa049111.61819525
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49639457
22Dilated cardiomyopathy_Homo sapiens_hsa054141.47473567
23Renin secretion_Homo sapiens_hsa049241.46326776
24Long-term depression_Homo sapiens_hsa047301.39636395
25Cholinergic synapse_Homo sapiens_hsa047251.38775007
26Dorso-ventral axis formation_Homo sapiens_hsa043201.38192140
27Glioma_Homo sapiens_hsa052141.37579559
28cAMP signaling pathway_Homo sapiens_hsa040241.35034826
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33127419
30Taste transduction_Homo sapiens_hsa047421.32419929
31Estrogen signaling pathway_Homo sapiens_hsa049151.32116740
32mTOR signaling pathway_Homo sapiens_hsa041501.29277599
33Gap junction_Homo sapiens_hsa045401.25596501
34VEGF signaling pathway_Homo sapiens_hsa043701.21931930
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19971175
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19646907
37Oocyte meiosis_Homo sapiens_hsa041141.19452416
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18703978
39Melanogenesis_Homo sapiens_hsa049161.16340982
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15317679
41Protein digestion and absorption_Homo sapiens_hsa049741.11778651
42Basal cell carcinoma_Homo sapiens_hsa052171.09547022
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.06982547
44Choline metabolism in cancer_Homo sapiens_hsa052311.06280215
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05909338
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.03297578
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02545464
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02338952
49ErbB signaling pathway_Homo sapiens_hsa040121.01997067
50Axon guidance_Homo sapiens_hsa043601.01807342
51Serotonergic synapse_Homo sapiens_hsa047260.98897674
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98724434
53Cardiac muscle contraction_Homo sapiens_hsa042600.98288349
54Type II diabetes mellitus_Homo sapiens_hsa049300.97104881
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95571967
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95395250
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93003392
58Amoebiasis_Homo sapiens_hsa051460.92617764
59Cocaine addiction_Homo sapiens_hsa050300.92553704
60Glucagon signaling pathway_Homo sapiens_hsa049220.91413303
61Rap1 signaling pathway_Homo sapiens_hsa040150.90169499
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90028640
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89480744
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86558797
65Nitrogen metabolism_Homo sapiens_hsa009100.84349564
66Adherens junction_Homo sapiens_hsa045200.84245445
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84107325
68Circadian rhythm_Homo sapiens_hsa047100.83115839
69Fatty acid biosynthesis_Homo sapiens_hsa000610.80279269
70MAPK signaling pathway_Homo sapiens_hsa040100.79510173
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79330214
72Wnt signaling pathway_Homo sapiens_hsa043100.76742943
73Hippo signaling pathway_Homo sapiens_hsa043900.73969353
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73719996
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.72778367
76Focal adhesion_Homo sapiens_hsa045100.72535731
77Tight junction_Homo sapiens_hsa045300.72101755
78Bladder cancer_Homo sapiens_hsa052190.71734760
79Ovarian steroidogenesis_Homo sapiens_hsa049130.69700847
80Notch signaling pathway_Homo sapiens_hsa043300.68391694
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66879010
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66264906
83Inositol phosphate metabolism_Homo sapiens_hsa005620.65894586
84Insulin signaling pathway_Homo sapiens_hsa049100.65178230
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.64920796
86Renal cell carcinoma_Homo sapiens_hsa052110.64821532
87Non-small cell lung cancer_Homo sapiens_hsa052230.64810435
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64049157
89Small cell lung cancer_Homo sapiens_hsa052220.62574911
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62376591
91Collecting duct acid secretion_Homo sapiens_hsa049660.62037711
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62023850
93Thyroid hormone synthesis_Homo sapiens_hsa049180.61677235
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59979258
95Ras signaling pathway_Homo sapiens_hsa040140.59752303
96Proteoglycans in cancer_Homo sapiens_hsa052050.59446089
97HIF-1 signaling pathway_Homo sapiens_hsa040660.59020684
98MicroRNAs in cancer_Homo sapiens_hsa052060.58687371
99Endocytosis_Homo sapiens_hsa041440.58567923
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57746216
101Fructose and mannose metabolism_Homo sapiens_hsa000510.57668885
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56418788
103Hedgehog signaling pathway_Homo sapiens_hsa043400.56008448
104* Pathways in cancer_Homo sapiens_hsa052000.55953086
105Pancreatic secretion_Homo sapiens_hsa049720.55759250
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53895272
107Thyroid cancer_Homo sapiens_hsa052160.53894188
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53771109
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53375179
110Chronic myeloid leukemia_Homo sapiens_hsa052200.50045426
111AMPK signaling pathway_Homo sapiens_hsa041520.48680471
112Prion diseases_Homo sapiens_hsa050200.47455623
113Bile secretion_Homo sapiens_hsa049760.47332722
114Vibrio cholerae infection_Homo sapiens_hsa051100.47285631
115Arginine biosynthesis_Homo sapiens_hsa002200.46772757
116Endometrial cancer_Homo sapiens_hsa052130.46739693
117ECM-receptor interaction_Homo sapiens_hsa045120.44606347
118Vitamin B6 metabolism_Homo sapiens_hsa007500.44315998
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.43395197

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »