PLEKHG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.05647535
2regulation of cilium movement (GO:0003352)8.68750311
3left/right axis specification (GO:0070986)7.73144049
4primary alcohol catabolic process (GO:0034310)7.00852076
5vitamin transmembrane transport (GO:0035461)6.85711064
6ventricular system development (GO:0021591)6.79138756
7microtubule bundle formation (GO:0001578)6.57543948
8intraciliary transport (GO:0042073)6.50314381
9diterpenoid biosynthetic process (GO:0016102)6.48178636
10cilium organization (GO:0044782)6.17454926
11ethanol metabolic process (GO:0006067)6.01528195
12cilium assembly (GO:0042384)5.96857039
13response to xenobiotic stimulus (GO:0009410)5.23317653
14pyrimidine-containing compound transmembrane transport (GO:0072531)5.16679276
15protein localization to cilium (GO:0061512)5.05303273
16centriole assembly (GO:0098534)5.02438832
17regulation of microtubule-based movement (GO:0060632)4.98863218
18one-carbon compound transport (GO:0019755)4.90173321
19microtubule-based movement (GO:0007018)4.79876131
20cellular component assembly involved in morphogenesis (GO:0010927)4.71880470
21terpenoid biosynthetic process (GO:0016114)4.67435884
22tolerance induction (GO:0002507)4.66540178
23regulation of interleukin-5 production (GO:0032674)4.50277634
24ethanol oxidation (GO:0006069)4.47406132
25cilium morphogenesis (GO:0060271)4.39402934
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.37635340
27negative regulation of B cell mediated immunity (GO:0002713)4.37635340
28negative regulation of T cell differentiation in thymus (GO:0033085)4.37623346
29retinoic acid metabolic process (GO:0042573)4.37199276
30lung epithelium development (GO:0060428)4.32358282
31cell projection assembly (GO:0030031)4.29028598
32lateral ventricle development (GO:0021670)4.21275674
33regulation of interleukin-13 production (GO:0032656)4.18206150
34sperm capacitation (GO:0048240)4.16292700
35regulation of germinal center formation (GO:0002634)4.10531726
36negative regulation of humoral immune response (GO:0002921)4.07962435
37nucleoside diphosphate phosphorylation (GO:0006165)3.97503027
38glomerular epithelial cell development (GO:0072310)3.87034530
39positive regulation of tolerance induction (GO:0002645)3.82292257
40establishment of apical/basal cell polarity (GO:0035089)3.81001904
41negative regulation of inclusion body assembly (GO:0090084)3.80012219
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.77566406
43exogenous drug catabolic process (GO:0042738)3.75822263
44cytoplasmic microtubule organization (GO:0031122)3.61799439
45establishment or maintenance of monopolar cell polarity (GO:0061339)3.44713248
46establishment of monopolar cell polarity (GO:0061162)3.44713248
47primary alcohol metabolic process (GO:0034308)3.31928336
48O-glycan processing (GO:0016266)3.29488144
49retinol metabolic process (GO:0042572)3.29326458
50establishment of tissue polarity (GO:0007164)3.25533864
51establishment of planar polarity (GO:0001736)3.25533864
52microtubule depolymerization (GO:0007019)3.16260462
53glutathione derivative metabolic process (GO:1901685)3.08613708
54glutathione derivative biosynthetic process (GO:1901687)3.08613708
55drug catabolic process (GO:0042737)3.06519396
56microtubule polymerization or depolymerization (GO:0031109)3.06233207
57axonemal dynein complex assembly (GO:0070286)21.9107984
58hydrogen peroxide biosynthetic process (GO:0050665)2.99029292
59determination of left/right symmetry (GO:0007368)2.98567724
60positive regulation of smoothened signaling pathway (GO:0045880)2.93264909
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92765144
62aldehyde catabolic process (GO:0046185)2.92744087
63sperm motility (GO:0030317)2.91413589
64carnitine metabolic process (GO:0009437)2.89038105
65regulation of tolerance induction (GO:0002643)2.88156198
66determination of bilateral symmetry (GO:0009855)2.85090026
67centriole replication (GO:0007099)2.85029586
68multicellular organismal water homeostasis (GO:0050891)2.79536816
69specification of symmetry (GO:0009799)2.77768191
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76860109
71microtubule-based process (GO:0007017)2.75394781
72calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.73082873
73retinal rod cell development (GO:0046548)2.71059764
74reactive oxygen species biosynthetic process (GO:1903409)2.67077639
75smoothened signaling pathway (GO:0007224)2.63583191
76lateral sprouting from an epithelium (GO:0060601)2.62897406
77regulation of microtubule depolymerization (GO:0031114)2.59631118
78phosphatidylcholine biosynthetic process (GO:0006656)2.58174705
79organelle assembly (GO:0070925)2.58079270
80oligosaccharide biosynthetic process (GO:0009312)2.57557198
81excretion (GO:0007588)2.53488413
82regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.52155934
83progesterone metabolic process (GO:0042448)2.50482588
84photoreceptor cell maintenance (GO:0045494)2.50010585
85intra-S DNA damage checkpoint (GO:0031573)2.48138384
86hypotonic response (GO:0006971)2.47391813
87hydrogen peroxide catabolic process (GO:0042744)2.43144586
88protein refolding (GO:0042026)2.43006551
89water homeostasis (GO:0030104)2.42183593
90heart looping (GO:0001947)2.41515024
91carnitine transmembrane transport (GO:1902603)2.40205341
92rRNA catabolic process (GO:0016075)2.40157569
93protein O-linked glycosylation (GO:0006493)2.39397669
94regulation of inclusion body assembly (GO:0090083)2.37527766
95cilium or flagellum-dependent cell motility (GO:0001539)19.5944199
96cilium movement (GO:0003341)16.4724382
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.3608785
98motile cilium assembly (GO:0044458)15.0006287
99epithelial cilium movement (GO:0003351)13.8679684
100axoneme assembly (GO:0035082)10.7634659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.57645056
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.70332320
3DROSHA_22980978_ChIP-Seq_HELA_Human3.39703526
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96230235
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89737273
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88217902
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60818797
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.29730603
9VDR_22108803_ChIP-Seq_LS180_Human2.21159277
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.06202936
11AHR_22903824_ChIP-Seq_MCF-7_Human2.02472038
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.91312599
13STAT1_20625510_ChIP-Seq_HELA_Human1.84396704
14FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.83349924
15FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79238787
16AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.71853583
17NR3C1_21868756_ChIP-Seq_MCF10A_Human1.70721589
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68321370
19* TP63_23658742_ChIP-Seq_EP156T_Human1.68279174
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.68018645
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.66410618
22TDRD3_21172665_ChIP-Seq_MCF-7_Human1.66023914
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.61151878
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58761571
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55591817
26* SMRT_27268052_Chip-Seq_Bcells_Human1.53254674
27SMC4_20622854_ChIP-Seq_HELA_Human1.52907480
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52435393
29ETV1_20927104_ChIP-Seq_GIST48_Human1.49191894
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48182180
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47344801
32FOXA1_25552417_ChIP-Seq_VCAP_Human1.45025073
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40442239
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.40357007
35SOX2_20726797_ChIP-Seq_SW620_Human1.39524939
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38158600
37TP53_18474530_ChIP-ChIP_U2OS_Human1.34893352
38PHF8_20622853_ChIP-Seq_HELA_Human1.34853264
39PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.34471120
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33483554
41* KLF5_25053715_ChIP-Seq_YYC3_Human1.32505125
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.31706223
43TP63_22573176_ChIP-Seq_HFKS_Human1.31439642
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.31056310
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29561133
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28723922
47TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28110761
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24003942
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.23286250
50RBPJ_21746931_ChIP-Seq_IB4_Human1.21753836
51GATA4_25053715_ChIP-Seq_YYC3_Human1.20520159
52CEBPB_22108803_ChIP-Seq_LS180_Human1.20400075
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17974823
54* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17864073
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.16617962
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15433254
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.14922308
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13308214
59GATA1_19941826_ChIP-Seq_K562_Human1.13162097
60GATA6_21074721_ChIP-Seq_CACO-2_Human1.12879404
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.12682991
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12682991
63NFYA_21822215_ChIP-Seq_K562_Human1.12358513
64SMAD4_21799915_ChIP-Seq_A2780_Human1.12172566
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11287676
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10101637
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10041244
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08453302
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08224227
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06612011
71FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05634635
72P300_27268052_Chip-Seq_Bcells_Human1.04795611
73NFYB_21822215_ChIP-Seq_K562_Human1.04260245
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.04034706
75CTCF_20526341_ChIP-Seq_ESCs_Human1.03037299
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.01567722
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99760490
78AR_20517297_ChIP-Seq_VCAP_Human0.97902892
79* GATA3_24758297_ChIP-Seq_MCF-7_Human0.97378504
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97177669
81STAT3_23295773_ChIP-Seq_U87_Human0.96463202
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.95984283
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.95771995
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95577221
85PHF8_20622854_ChIP-Seq_HELA_Human0.94939112
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94118551
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94050960
88TCF4_22108803_ChIP-Seq_LS180_Human0.94013094
89BCAT_22108803_ChIP-Seq_LS180_Human0.93966251
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93396091
91TBL1_22424771_ChIP-Seq_293T_Human0.92966585
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91753195
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91724150
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.91348210
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91023763
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.90959521
97SOX2_21211035_ChIP-Seq_LN229_Human0.90055419
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89419337
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88604912
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88020838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.94437730
2MP0008875_abnormal_xenobiotic_pharmacok6.92173255
3MP0002132_abnormal_respiratory_system5.42277194
4MP0004043_abnormal_pH_regulation4.27697724
5MP0001984_abnormal_olfaction3.99907501
6MP0002277_abnormal_respiratory_mucosa3.94775796
7MP0005623_abnormal_meninges_morphology3.51564292
8MP0004133_heterotaxia3.28348335
9MP0008789_abnormal_olfactory_epithelium3.19712406
10MP0009780_abnormal_chondrocyte_physiolo2.92484470
11MP0000383_abnormal_hair_follicle2.32486159
12MP0005377_hearing/vestibular/ear_phenot2.20154276
13MP0003878_abnormal_ear_physiology2.20154276
14MP0002168_other_aberrant_phenotype2.12579568
15MP0010678_abnormal_skin_adnexa2.05654297
16MP0005394_taste/olfaction_phenotype2.01307309
17MP0005499_abnormal_olfactory_system2.01307309
18MP0002160_abnormal_reproductive_system1.98487078
19MP0002282_abnormal_trachea_morphology1.97060681
20MP0004019_abnormal_vitamin_homeostasis1.96073417
21MP0001765_abnormal_ion_homeostasis1.95752115
22MP0000566_synostosis1.91502590
23MP0003656_abnormal_erythrocyte_physiolo1.75331823
24MP0005083_abnormal_biliary_tract1.74309093
25MP0000678_abnormal_parathyroid_gland1.52475762
26MP0001346_abnormal_lacrimal_gland1.48498950
27MP0010155_abnormal_intestine_physiology1.43673034
28MP0005395_other_phenotype1.41920929
29MP0002909_abnormal_adrenal_gland1.41445217
30MP0000465_gastrointestinal_hemorrhage1.41340578
31MP0002876_abnormal_thyroid_physiology1.31295353
32MP0005636_abnormal_mineral_homeostasis1.29190182
33MP0005165_increased_susceptibility_to1.24526684
34MP0010234_abnormal_vibrissa_follicle1.22566539
35MP0009046_muscle_twitch1.17837322
36MP0002735_abnormal_chemical_nociception1.15032154
37MP0001790_abnormal_immune_system1.13219553
38MP0005387_immune_system_phenotype1.13219553
39MP0005310_abnormal_salivary_gland1.09638068
40MP0005389_reproductive_system_phenotype1.08684514
41MP0002405_respiratory_system_inflammati1.06011584
42MP0001485_abnormal_pinna_reflex1.05358178
43MP0005220_abnormal_exocrine_pancreas1.02781400
44MP0003303_peritoneal_inflammation1.02405399
45MP0002638_abnormal_pupillary_reflex0.96033285
46MP0004264_abnormal_extraembryonic_tissu0.94490527
47MP0000681_abnormal_thyroid_gland0.94422403
48MP0002139_abnormal_hepatobiliary_system0.93326992
49MP0009643_abnormal_urine_homeostasis0.93238817
50MP0002734_abnormal_mechanical_nocicepti0.92922347
51MP0002233_abnormal_nose_morphology0.90921428
52MP0002136_abnormal_kidney_physiology0.90711644
53MP0003195_calcinosis0.88800645
54MP0005164_abnormal_response_to0.87758201
55MP0009379_abnormal_foot_pigmentation0.87558199
56MP0002249_abnormal_larynx_morphology0.83464171
57MP0005248_abnormal_Harderian_gland0.81204753
58MP0005253_abnormal_eye_physiology0.80047952
59MP0001929_abnormal_gametogenesis0.77893745
60MP0009765_abnormal_xenobiotic_induced0.76996410
61MP0003698_abnormal_male_reproductive0.75640026
62MP0005365_abnormal_bile_salt0.75000750
63MP0002098_abnormal_vibrissa_morphology0.71225415
64MP0003866_abnormal_defecation0.71132476
65MP0005085_abnormal_gallbladder_physiolo0.69502887
66MP0004883_abnormal_blood_vessel0.68006318
67MP0005551_abnormal_eye_electrophysiolog0.67270081
68MP0003045_fibrosis0.66027712
69MP0009763_increased_sensitivity_to0.65993973
70MP0008872_abnormal_physiological_respon0.65184573
71MP0001270_distended_abdomen0.64956237
72MP0001835_abnormal_antigen_presentation0.61466043
73MP0003890_abnormal_embryonic-extraembry0.61009421
74MP0001664_abnormal_digestion0.60921079
75MP0006082_CNS_inflammation0.58994878
76MP0002928_abnormal_bile_duct0.58681124
77MP0001293_anophthalmia0.56437109
78MP0002133_abnormal_respiratory_system0.53665848
79MP0005388_respiratory_system_phenotype0.53665848
80MP0002229_neurodegeneration0.52353253
81MP0005645_abnormal_hypothalamus_physiol0.52336538
82MP0001879_abnormal_lymphatic_vessel0.52267948
83MP0005025_abnormal_response_to0.50496648
84MP0004782_abnormal_surfactant_physiolog0.50470162
85MP0003075_altered_response_to0.50466745
86MP0001663_abnormal_digestive_system0.48512897
87MP0000026_abnormal_inner_ear0.48355227
88MP0001188_hyperpigmentation0.48284437
89MP0001545_abnormal_hematopoietic_system0.46986372
90MP0005397_hematopoietic_system_phenotyp0.46986372
91MP0006036_abnormal_mitochondrial_physio0.46977450
92MP0005408_hypopigmentation0.45593846
93MP0001324_abnormal_eye_pigmentation0.44967547
94MP0000858_altered_metastatic_potential0.44937815
95MP0003191_abnormal_cellular_cholesterol0.44216015
96MP0002135_abnormal_kidney_morphology0.41476793
97MP0005195_abnormal_posterior_eye0.41372641
98MP0003136_yellow_coat_color0.41149711
99MP0003763_abnormal_thymus_physiology0.40489744
100MP0009703_decreased_birth_body0.40393289

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.76671907
2Bronchiectasis (HP:0002110)7.45746994
3Nasal polyposis (HP:0100582)6.54752723
4Abnormality of the nasal mucosa (HP:0000433)5.43487441
5Recurrent sinusitis (HP:0011108)4.62704588
6Bronchitis (HP:0012387)4.59446632
7Chronic sinusitis (HP:0011109)4.29920911
8Infertility (HP:0000789)4.15925806
9Recurrent otitis media (HP:0000403)3.92236935
10Male infertility (HP:0003251)3.82761150
11Pancreatic fibrosis (HP:0100732)3.63108216
12True hermaphroditism (HP:0010459)3.54353117
13Occipital encephalocele (HP:0002085)3.53102077
14Chronic otitis media (HP:0000389)3.22223445
15Molar tooth sign on MRI (HP:0002419)3.07950343
16Abnormality of midbrain morphology (HP:0002418)3.07950343
17Pancreatic cysts (HP:0001737)2.99981440
18Hyperactive renin-angiotensin system (HP:0000841)2.94497766
19Cystic liver disease (HP:0006706)2.94067514
20Nephronophthisis (HP:0000090)2.93460635
21Atelectasis (HP:0100750)2.84402791
22Chronic hepatic failure (HP:0100626)2.51311333
23Postaxial foot polydactyly (HP:0001830)2.48801724
24Recurrent bronchitis (HP:0002837)2.41354256
25Abnormality of the renal medulla (HP:0100957)2.31429855
26Tubulointerstitial nephritis (HP:0001970)2.27803415
27Congenital hepatic fibrosis (HP:0002612)2.19563951
28Anencephaly (HP:0002323)2.02539497
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.02289200
30Medial flaring of the eyebrow (HP:0010747)2.01167510
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3530642
32Abnormal respiratory epithelium morphology (HP:0012253)11.2157087
33Abnormal respiratory motile cilium morphology (HP:0005938)11.2157087
34Dynein arm defect of respiratory motile cilia (HP:0012255)11.0130501
35Absent/shortened dynein arms (HP:0200106)11.0130501
36Abnormal respiratory motile cilium physiology (HP:0012261)10.9491491
37Abnormal ciliary motility (HP:0012262)10.7806719
38Rhinitis (HP:0012384)10.0469201
39Asplenia (HP:0001746)1.96124299
40Male pseudohermaphroditism (HP:0000037)1.95445461
41Bell-shaped thorax (HP:0001591)1.95443852
42Aplasia/Hypoplasia of the spleen (HP:0010451)1.93692101
43Decreased circulating renin level (HP:0003351)1.90712346
44Absent frontal sinuses (HP:0002688)1.88935309
45Congenital primary aphakia (HP:0007707)1.82323565
46Renal salt wasting (HP:0000127)1.80366183
47Gait imbalance (HP:0002141)1.79353870
48Furrowed tongue (HP:0000221)1.75499807
49Tubular atrophy (HP:0000092)1.71000968
50Oculomotor apraxia (HP:0000657)1.70220923
51Sclerocornea (HP:0000647)1.68614473
52Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68055214
53Hyperkalemia (HP:0002153)1.66634534
54Nephropathy (HP:0000112)1.63508177
55Postaxial hand polydactyly (HP:0001162)1.60382371
56Nephrogenic diabetes insipidus (HP:0009806)1.56066204
57Hyperaldosteronism (HP:0000859)1.52363365
58Decreased central vision (HP:0007663)1.46431878
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45324602
60Abnormality of chloride homeostasis (HP:0011422)1.44005370
61Median cleft lip (HP:0000161)1.39687873
62Abnormality of renin-angiotensin system (HP:0000847)1.39138682
63Hypokalemic alkalosis (HP:0001949)1.34007273
64Cone-rod dystrophy (HP:0000548)1.31169061
65Preaxial hand polydactyly (HP:0001177)1.30924396
66Short thorax (HP:0010306)1.26183787
67Abnormality of the frontal sinuses (HP:0002687)1.25881303
68Tubulointerstitial abnormality (HP:0001969)1.25441883
69Abnormal biliary tract physiology (HP:0012439)1.22577542
70Bile duct proliferation (HP:0001408)1.22577542
71Abnormality of the dental root (HP:0006486)1.21901799
72Taurodontia (HP:0000679)1.21901799
73Abnormality of permanent molar morphology (HP:0011071)1.21901799
74Poor coordination (HP:0002370)1.21632588
75Genital tract atresia (HP:0001827)1.21162166
76Vaginal atresia (HP:0000148)1.20193440
77Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18326807
78Stage 5 chronic kidney disease (HP:0003774)1.14370478
79Glucose intolerance (HP:0000833)1.12552557
80Abnormality of molar morphology (HP:0011070)1.11072274
81Abnormality of molar (HP:0011077)1.11072274
82Abnormal rod and cone electroretinograms (HP:0008323)1.10741369
83Fetal akinesia sequence (HP:0001989)1.09644279
84Hand muscle atrophy (HP:0009130)1.09559586
85Abnormality of the distal phalanges of the toes (HP:0010182)1.08752446
86Abnormality of the renal cortex (HP:0011035)1.08030267
87Abnormality of the dental pulp (HP:0006479)1.07116721
88Hyponatremia (HP:0002902)1.06938909
89Lip pit (HP:0100267)1.04608189
90Absent speech (HP:0001344)1.04505258
91Popliteal pterygium (HP:0009756)1.03933673
92Bifid scrotum (HP:0000048)1.02283605
93Retinitis pigmentosa (HP:0000510)1.02197989
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.02157537
95Aplasia of the musculature (HP:0100854)1.02111798
96Abnormal drinking behavior (HP:0030082)1.01603155
97Polydipsia (HP:0001959)1.01603155
98Abnormality of macular pigmentation (HP:0008002)1.00170209
99Supernumerary spleens (HP:0009799)0.97449498
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)0.97419107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.88915353
2EPHA24.41715096
3NME12.52421680
4MAPKAPK32.29289708
5BCR2.19741473
6MAP3K22.00373423
7MAPK1511.5745645
8STK241.78205716
9EPHA31.73762774
10PTK2B1.69891326
11SMG11.67259896
12TTK1.62681358
13CSK1.51798995
14EEF2K1.36057917
15EPHB11.31708168
16PNCK1.31147781
17MAP3K31.28840991
18RIPK41.23698617
19MST1R1.18724533
20TBK11.15582567
21TLK11.14407338
22STK101.07606178
23MAP3K70.98099605
24LRRK20.98029369
25TRPM70.94106585
26NEK60.93874032
27FRK0.89508179
28GRK10.85234395
29CAMKK10.85118798
30TESK10.77893626
31PRKCI0.75430639
32INSRR0.71805580
33BRSK20.68855764
34PRKCQ0.67701633
35ERBB30.67472860
36ICK0.66013911
37FGFR30.65036546
38IRAK10.63017960
39ADRBK20.62456849
40CDK190.59204948
41OXSR10.58153863
42MARK20.57150263
43CAMKK20.57149195
44MAP3K40.54551318
45FER0.52999947
46PRKCD0.52977314
47STK380.50788761
48GRK60.50018798
49NLK0.48452869
50AURKA0.48129730
51HIPK20.46919522
52ERBB20.44319390
53TAOK30.43616921
54MATK0.43460577
55MAP3K120.43401062
56PBK0.39665934
57STK390.39383473
58STK160.38939603
59MAP2K70.38425383
60TEC0.38351672
61SGK10.37031730
62RPS6KB20.35768301
63DYRK1B0.34431026
64PRKAA20.34268659
65NEK90.33632420
66KIT0.32013725
67ACVR1B0.31478887
68ABL10.31126399
69LMTK20.30862977
70ADRBK10.30061092
71BMPR20.29223614
72CAMK2G0.26638040
73PRKACA0.26191217
74MAPK130.25615495
75PASK0.24700527
76BTK0.24657721
77PRKCA0.23574523
78DYRK1A0.23411412
79MAP4K20.21987426
80CHUK0.21306148
81TYK20.20859502
82EGFR0.19582846
83IKBKE0.19423007
84BMPR1B0.19257323
85MET0.18994108
86MAP3K140.18614919
87FYN0.18554443
88IGF1R0.18392612
89TSSK60.18021054
90LYN0.17176079
91AKT20.17128106
92PDPK10.17030891
93MAP2K40.16497068
94CDK60.16103993
95MAPKAPK50.15726035
96SRC0.15630770
97PRKCH0.15033683
98PLK10.13822960
99TAOK10.13615799
100ROCK20.13584756

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.49421107
2Histidine metabolism_Homo sapiens_hsa003404.50930433
3Chemical carcinogenesis_Homo sapiens_hsa052044.50084938
4Phenylalanine metabolism_Homo sapiens_hsa003604.46980587
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.28160185
6Tyrosine metabolism_Homo sapiens_hsa003503.46526755
7beta-Alanine metabolism_Homo sapiens_hsa004103.05037285
8Caffeine metabolism_Homo sapiens_hsa002322.89022113
9Huntingtons disease_Homo sapiens_hsa050162.74531125
10Retinol metabolism_Homo sapiens_hsa008302.41768859
11Glutathione metabolism_Homo sapiens_hsa004802.38831941
12Linoleic acid metabolism_Homo sapiens_hsa005912.28435753
13ABC transporters_Homo sapiens_hsa020101.76993788
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69422119
15Sphingolipid metabolism_Homo sapiens_hsa006001.68186538
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64533884
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63741271
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.56535816
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53517674
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37927925
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33642412
22Peroxisome_Homo sapiens_hsa041461.31810458
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.25596971
24Allograft rejection_Homo sapiens_hsa053301.24971335
25Arachidonic acid metabolism_Homo sapiens_hsa005901.24707624
26Fatty acid degradation_Homo sapiens_hsa000711.21337477
27Asthma_Homo sapiens_hsa053101.20036659
28Tight junction_Homo sapiens_hsa045301.11185474
29Salivary secretion_Homo sapiens_hsa049701.11145124
30Autoimmune thyroid disease_Homo sapiens_hsa053201.10457517
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08332443
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07341956
33Starch and sucrose metabolism_Homo sapiens_hsa005001.05275458
34Type I diabetes mellitus_Homo sapiens_hsa049401.04526158
35Graft-versus-host disease_Homo sapiens_hsa053321.01701378
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00979545
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00386702
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.94018331
39Hematopoietic cell lineage_Homo sapiens_hsa046400.91813561
40Circadian rhythm_Homo sapiens_hsa047100.87287697
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81633051
42Taste transduction_Homo sapiens_hsa047420.80131507
43Hepatitis C_Homo sapiens_hsa051600.69322711
44Phototransduction_Homo sapiens_hsa047440.66844471
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64697158
46Antigen processing and presentation_Homo sapiens_hsa046120.62182561
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58215868
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.56924497
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.53049431
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52656628
51Olfactory transduction_Homo sapiens_hsa047400.51988128
52Nitrogen metabolism_Homo sapiens_hsa009100.51457946
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51149047
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50936992
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.49743563
56Choline metabolism in cancer_Homo sapiens_hsa052310.47866322
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43796041
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.40311403
59Complement and coagulation cascades_Homo sapiens_hsa046100.37175300
60Collecting duct acid secretion_Homo sapiens_hsa049660.35584090
61Staphylococcus aureus infection_Homo sapiens_hsa051500.35098177
62Vitamin digestion and absorption_Homo sapiens_hsa049770.33304596
63Notch signaling pathway_Homo sapiens_hsa043300.32820264
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32448475
65Metabolic pathways_Homo sapiens_hsa011000.29928703
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29463361
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29149302
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28322276
69PPAR signaling pathway_Homo sapiens_hsa033200.26209975
70Hedgehog signaling pathway_Homo sapiens_hsa043400.24609841
71Serotonergic synapse_Homo sapiens_hsa047260.24186604
72Rheumatoid arthritis_Homo sapiens_hsa053230.24173560
73Butanoate metabolism_Homo sapiens_hsa006500.23902581
74Calcium signaling pathway_Homo sapiens_hsa040200.23501322
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.23496781
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22931631
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22729363
78Amoebiasis_Homo sapiens_hsa051460.22038463
79Glycerolipid metabolism_Homo sapiens_hsa005610.21459064
80Nicotine addiction_Homo sapiens_hsa050330.21275925
81Tryptophan metabolism_Homo sapiens_hsa003800.20623351
82Pancreatic secretion_Homo sapiens_hsa049720.19101733
83Arginine and proline metabolism_Homo sapiens_hsa003300.18224744
84Influenza A_Homo sapiens_hsa051640.17524017
85Systemic lupus erythematosus_Homo sapiens_hsa053220.17199692
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17002272
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15749876
88Primary immunodeficiency_Homo sapiens_hsa053400.15315039
89cAMP signaling pathway_Homo sapiens_hsa040240.13683800
90Phagosome_Homo sapiens_hsa041450.13495036
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.13456016
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13405616
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13019504
94Regulation of autophagy_Homo sapiens_hsa041400.11897315
95Fatty acid biosynthesis_Homo sapiens_hsa000610.11460172
96Viral myocarditis_Homo sapiens_hsa054160.11249151
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11089953
98Adherens junction_Homo sapiens_hsa045200.10754930
99Lysosome_Homo sapiens_hsa041420.07991648
100p53 signaling pathway_Homo sapiens_hsa041150.06785203

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