PLEKHH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.01562872
2ensheathment of neurons (GO:0007272)6.93542122
3axon ensheathment (GO:0008366)6.93542122
4myelination (GO:0042552)6.90164277
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.49945213
6glutamate secretion (GO:0014047)5.76077126
7myelin maintenance (GO:0043217)5.67045205
8long-chain fatty acid biosynthetic process (GO:0042759)5.47060240
9cellular potassium ion homeostasis (GO:0030007)5.36128423
10synaptic vesicle exocytosis (GO:0016079)5.10639776
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.07042172
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.96783527
13sodium ion export (GO:0071436)4.94248805
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94061246
15negative regulation of neurotransmitter secretion (GO:0046929)4.90195554
16apical protein localization (GO:0045176)4.86259078
17establishment of mitochondrion localization (GO:0051654)4.78405920
18regulation of synaptic vesicle exocytosis (GO:2000300)4.62850800
19asymmetric protein localization (GO:0008105)4.62039399
20negative regulation of neurotransmitter transport (GO:0051589)4.51133520
21neurotransmitter secretion (GO:0007269)4.40388243
22creatine metabolic process (GO:0006600)4.35932184
23glycerophospholipid catabolic process (GO:0046475)4.29466405
24oligodendrocyte differentiation (GO:0048709)4.28594546
25regulation of neuronal synaptic plasticity (GO:0048168)4.24870946
26vocalization behavior (GO:0071625)4.18134475
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.15532344
28L-amino acid import (GO:0043092)4.14009524
29photoreceptor cell differentiation (GO:0046530)4.12908633
30eye photoreceptor cell differentiation (GO:0001754)4.12908633
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11818014
32potassium ion homeostasis (GO:0055075)4.08108493
33locomotory exploration behavior (GO:0035641)4.07441567
34negative regulation of protein localization to cell surface (GO:2000009)4.05189661
35peptidyl-tyrosine autophosphorylation (GO:0038083)4.02501454
36regulation of synaptic vesicle transport (GO:1902803)4.00867778
37potassium ion import (GO:0010107)3.98404780
38cholesterol biosynthetic process (GO:0006695)3.97845168
39membrane tubulation (GO:0097320)3.97332436
40cerebellar granule cell differentiation (GO:0021707)3.96011141
41astrocyte development (GO:0014002)3.94250440
42regulation of collateral sprouting (GO:0048670)3.89359429
43positive regulation of synapse maturation (GO:0090129)3.88473887
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86979687
45positive regulation of oligodendrocyte differentiation (GO:0048714)3.83494429
46postsynaptic membrane organization (GO:0001941)3.81414868
47amyloid precursor protein metabolic process (GO:0042982)3.77173727
48neuron cell-cell adhesion (GO:0007158)3.77050163
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73501062
50neurotransmitter transport (GO:0006836)3.70129837
51virion attachment to host cell (GO:0019062)3.65055210
52adhesion of symbiont to host cell (GO:0044650)3.65055210
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63894580
54cellular sodium ion homeostasis (GO:0006883)3.60240800
55synaptic transmission, glutamatergic (GO:0035249)3.56600067
56long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.55372010
57neurotransmitter-gated ion channel clustering (GO:0072578)3.52301392
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50493011
59sterol biosynthetic process (GO:0016126)3.48311605
60peripheral nervous system axon ensheathment (GO:0032292)3.47218605
61myelination in peripheral nervous system (GO:0022011)3.47218605
62regulation of neurotransmitter levels (GO:0001505)3.44620035
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.43930286
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43611966
65presynaptic membrane organization (GO:0097090)3.42505170
66protein palmitoylation (GO:0018345)3.42391758
67adult walking behavior (GO:0007628)3.41079483
68positive regulation of membrane potential (GO:0045838)3.39488673
69response to methylmercury (GO:0051597)3.39474591
70cell communication by electrical coupling (GO:0010644)3.36043149
71glutamate receptor signaling pathway (GO:0007215)3.35988493
72response to lipoprotein particle (GO:0055094)3.35741014
73protein localization to endosome (GO:0036010)3.34540292
74exploration behavior (GO:0035640)3.33579939
75substantia nigra development (GO:0021762)3.32604069
76long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.32212832
77protein localization to synapse (GO:0035418)3.32191988
78gamma-aminobutyric acid transport (GO:0015812)3.31758301
79import into cell (GO:0098657)3.31146654
80regulation of glutamate receptor signaling pathway (GO:1900449)3.28601168
81neuromuscular process controlling balance (GO:0050885)3.24720224
82regulation of lipoprotein metabolic process (GO:0050746)3.24109485
83regulation of synaptic plasticity (GO:0048167)3.23541158
84response to redox state (GO:0051775)3.23219275
85acidic amino acid transport (GO:0015800)3.23191673
86magnesium ion transport (GO:0015693)3.21240631
87positive regulation of dendritic spine development (GO:0060999)3.18021007
88neuron-neuron synaptic transmission (GO:0007270)3.16638388
89regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16440854
90regulation of ARF protein signal transduction (GO:0032012)3.16177611
91regulation of synapse maturation (GO:0090128)3.16168507
92cytoskeletal anchoring at plasma membrane (GO:0007016)3.10590798
93regulation of neurotransmitter secretion (GO:0046928)3.09248623
94Golgi to endosome transport (GO:0006895)3.06980510
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06770671
96amino acid import (GO:0043090)3.06647013
97cerebellar Purkinje cell differentiation (GO:0021702)3.04642505
98positive regulation of action potential (GO:0045760)3.04589008
99fatty-acyl-CoA biosynthetic process (GO:0046949)3.04365691
100auditory behavior (GO:0031223)3.03201934
101glycosylceramide metabolic process (GO:0006677)3.02201295
102peptidyl-cysteine modification (GO:0018198)2.99864896
103neuronal action potential propagation (GO:0019227)2.99836178
104synaptic vesicle endocytosis (GO:0048488)2.99450211
105transmission of nerve impulse (GO:0019226)2.98954831
106long-term synaptic potentiation (GO:0060291)2.98399724
107regulation of postsynaptic membrane potential (GO:0060078)2.98042202
108isoprenoid biosynthetic process (GO:0008299)2.97429765
109membrane depolarization during action potential (GO:0086010)2.96344594
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.94526631
111regulation of neurotransmitter transport (GO:0051588)2.93335115
112phosphorelay signal transduction system (GO:0000160)2.92831603
113glycine transport (GO:0015816)2.90084839
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88793352
115negative regulation of dendrite morphogenesis (GO:0050774)2.88646101
116GPI anchor biosynthetic process (GO:0006506)2.88445965
117L-glutamate transport (GO:0015813)2.88346178
118positive regulation of dendrite development (GO:1900006)2.87439724
119proline transport (GO:0015824)2.87426365
120regulation of voltage-gated calcium channel activity (GO:1901385)2.86540990
121presynaptic membrane assembly (GO:0097105)2.85645971
122fatty-acyl-CoA metabolic process (GO:0035337)2.85185372
123cell communication involved in cardiac conduction (GO:0086065)2.84943346
124negative regulation of axonogenesis (GO:0050771)2.84325079
125regulation of dendritic spine morphogenesis (GO:0061001)2.83443909
126neuronal ion channel clustering (GO:0045161)2.81391225
127positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.81233407
128GPI anchor metabolic process (GO:0006505)2.78123177
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77263973
130membrane hyperpolarization (GO:0060081)2.76310150
131regulation of synapse structural plasticity (GO:0051823)2.75949679
132long-term memory (GO:0007616)2.75522421
133axon development (GO:0061564)2.75371037
134preassembly of GPI anchor in ER membrane (GO:0016254)2.73599986
135membrane depolarization (GO:0051899)2.73230770
136nerve growth factor signaling pathway (GO:0038180)2.73056728
137peripheral nervous system development (GO:0007422)2.72943431
138regulation of vesicle fusion (GO:0031338)2.72586047
139positive regulation of glial cell differentiation (GO:0045687)2.71833990
140negative regulation of JUN kinase activity (GO:0043508)2.71776530
141negative regulation of macroautophagy (GO:0016242)2.69990276
142regulation of dendritic spine development (GO:0060998)2.69875448
143iron coordination entity transport (GO:1901678)2.68193945
144regulation of synaptic transmission (GO:0050804)2.66876657
145organ growth (GO:0035265)2.66212179
146C4-dicarboxylate transport (GO:0015740)2.64929774
147cerebral cortex radially oriented cell migration (GO:0021799)2.64552866
148positive regulation of gliogenesis (GO:0014015)2.64036096
149neuromuscular synaptic transmission (GO:0007274)2.63919170
150establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63199874
151mitochondrion transport along microtubule (GO:0047497)2.63199874
152neurotransmitter uptake (GO:0001504)2.62628378
153positive regulation of pseudopodium assembly (GO:0031274)2.61886756
154response to auditory stimulus (GO:0010996)2.61444716
155very long-chain fatty acid metabolic process (GO:0000038)2.59374160
156adhesion of symbiont to host (GO:0044406)2.56397339
157glial cell development (GO:0021782)2.55786813
158enteric nervous system development (GO:0048484)2.54929447
159response to dietary excess (GO:0002021)2.54320592
160positive regulation of neurological system process (GO:0031646)2.54078936
161limb bud formation (GO:0060174)2.53516855
162amyloid precursor protein catabolic process (GO:0042987)2.51199577
163heme transport (GO:0015886)2.50651559
164Golgi to plasma membrane protein transport (GO:0043001)2.50405706
165negative regulation of inclusion body assembly (GO:0090084)2.49148713
166Leydig cell differentiation (GO:0033327)2.45156640
167microtubule polymerization or depolymerization (GO:0031109)2.44668138
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.43433791
169substrate-independent telencephalic tangential migration (GO:0021826)2.43433791
170dendritic spine morphogenesis (GO:0060997)2.43319858
171neuron remodeling (GO:0016322)2.41270247
172synaptic vesicle maturation (GO:0016188)2.40594228
173phosphatidylserine metabolic process (GO:0006658)2.40465255
174ear development (GO:0043583)2.39928026
175thioester biosynthetic process (GO:0035384)2.38767529
176axon ensheathment in central nervous system (GO:0032291)12.0353436
177central nervous system myelination (GO:0022010)12.0353436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.92659120
2GBX2_23144817_ChIP-Seq_PC3_Human2.63708847
3SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.36278563
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09491336
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05771397
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04744104
7EZH2_22144423_ChIP-Seq_EOC_Human2.00860763
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00387447
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99900728
10MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91908090
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88959843
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88959843
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88959843
14* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.85766734
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.82712877
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82148749
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82148749
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80523214
19DROSHA_22980978_ChIP-Seq_HELA_Human1.79176472
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79147897
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75657159
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.71308102
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71145633
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.66635624
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66309735
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64788343
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64761848
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61444906
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.58099482
30VDR_22108803_ChIP-Seq_LS180_Human1.55754975
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.55284652
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48450073
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47813473
34AR_21572438_ChIP-Seq_LNCaP_Human1.47528622
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45195792
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.44907152
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.42654437
38* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37885513
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37461858
40TAF15_26573619_Chip-Seq_HEK293_Human1.36433824
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36323156
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33842368
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33453827
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.32826542
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.28455671
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28247061
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.27807609
48AR_19668381_ChIP-Seq_PC3_Human1.27629767
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27161318
50ER_23166858_ChIP-Seq_MCF-7_Human1.26906791
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24757170
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24690296
53AHR_22903824_ChIP-Seq_MCF-7_Human1.24260987
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23678666
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21849267
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21267759
57SMAD4_21799915_ChIP-Seq_A2780_Human1.21104149
58KDM2B_26808549_Chip-Seq_K562_Human1.20150265
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.19556070
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18651903
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17376626
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16911071
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16725696
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16610821
65REST_21632747_ChIP-Seq_MESCs_Mouse1.16377100
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.15438964
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15002724
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.14858439
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14254041
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14028451
71STAT3_23295773_ChIP-Seq_U87_Human1.13123190
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.13078260
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12920122
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10602586
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.10241815
76* EOMES_21245162_ChIP-Seq_HESCs_Human1.09921552
77RNF2_27304074_Chip-Seq_NSC_Mouse1.09142812
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.09049807
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08750218
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.08221739
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07937256
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07778739
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07575316
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.07276209
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.06740583
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.06227885
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05012608
88* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04680840
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04635721
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04358166
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03389052
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02577804
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02507322
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02056716
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01008596
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.00561968
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00222559
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99413051
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98026494
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97799608
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97690130
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96678448
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96678448
104* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96586403
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96114234
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95841746
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95841397
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.94902386
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94592237
110TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94157486
111TCF4_23295773_ChIP-Seq_U87_Human0.94021578
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93865304
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93601932
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93419245
115TP53_16413492_ChIP-PET_HCT116_Human0.93041659
116* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92903020
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92512450
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92512450
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92314093
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91969993
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91890658
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91737335
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91634168
124* CTCF_27219007_Chip-Seq_Bcells_Human0.91393095
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90686827
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90223394
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89966214
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89923279
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89664775
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89436100
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88713941
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.88349526
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88274769
134TBL1_22424771_ChIP-Seq_293T_Human0.87605819
135* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87574556
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87327841
137NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85886588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.18132835
2MP0003950_abnormal_plasma_membrane4.00450972
3MP0004270_analgesia3.64280977
4MP0003880_abnormal_central_pattern3.28291337
5MP0004885_abnormal_endolymph3.14091861
6MP0003690_abnormal_glial_cell2.85223282
7MP0004043_abnormal_pH_regulation2.54928048
8MP0004859_abnormal_synaptic_plasticity2.51796441
9MP0003329_amyloid_beta_deposits2.49941367
10MP0001485_abnormal_pinna_reflex2.49311147
11MP0001968_abnormal_touch/_nociception2.47963110
12MP0010678_abnormal_skin_adnexa2.47627923
13MP0002272_abnormal_nervous_system2.39359583
14MP0001486_abnormal_startle_reflex2.38848722
15MP0001529_abnormal_vocalization2.35624984
16MP0003634_abnormal_glial_cell2.33385875
17MP0003136_yellow_coat_color2.30053551
18MP0005171_absent_coat_pigmentation2.28024553
19MP0000462_abnormal_digestive_system2.23859261
20MP0004742_abnormal_vestibular_system2.21847890
21MP0001501_abnormal_sleep_pattern2.17627871
22MP0002064_seizures2.12605409
23MP0004142_abnormal_muscle_tone2.11843211
24MP0003879_abnormal_hair_cell2.11724759
25MP0002735_abnormal_chemical_nociception2.11665229
26MP0005646_abnormal_pituitary_gland2.03527155
27MP0000778_abnormal_nervous_system2.02335592
28MP0000383_abnormal_hair_follicle1.99515716
29MP0001905_abnormal_dopamine_level1.98963079
30MP0003632_abnormal_nervous_system1.95475659
31MP0002229_neurodegeneration1.85541409
32MP0003635_abnormal_synaptic_transmissio1.81689537
33MP0009046_muscle_twitch1.74153273
34MP0002734_abnormal_mechanical_nocicepti1.71935188
35MP0002736_abnormal_nociception_after1.69290863
36MP0005410_abnormal_fertilization1.68174952
37MP0002822_catalepsy1.67858860
38MP0005423_abnormal_somatic_nervous1.67432001
39MP0000955_abnormal_spinal_cord1.60864701
40MP0009745_abnormal_behavioral_response1.60343338
41MP0001502_abnormal_circadian_rhythm1.55065790
42MP0001984_abnormal_olfaction1.51132116
43MP0000537_abnormal_urethra_morphology1.46750654
44MP0003631_nervous_system_phenotype1.42028996
45MP0005623_abnormal_meninges_morphology1.41245034
46MP0005409_darkened_coat_color1.38954712
47MP0002882_abnormal_neuron_morphology1.34704213
48MP0002572_abnormal_emotion/affect_behav1.29626826
49MP0002063_abnormal_learning/memory/cond1.29613725
50MP0003787_abnormal_imprinting1.28559548
51MP0001346_abnormal_lacrimal_gland1.27835989
52MP0003123_paternal_imprinting1.26026292
53MP0001440_abnormal_grooming_behavior1.25573314
54MP0005451_abnormal_body_composition1.24178723
55MP0002066_abnormal_motor_capabilities/c1.23375924
56MP0003633_abnormal_nervous_system1.21266484
57MP0001970_abnormal_pain_threshold1.20707479
58MP0008569_lethality_at_weaning1.20184336
59MP0000566_synostosis1.18932895
60MP0000747_muscle_weakness1.18191886
61MP0003806_abnormal_nucleotide_metabolis1.16428135
62MP0001963_abnormal_hearing_physiology1.11968473
63MP0004134_abnormal_chest_morphology1.11527050
64MP0004924_abnormal_behavior1.10674506
65MP0005386_behavior/neurological_phenoty1.10674506
66MP0003937_abnormal_limbs/digits/tail_de1.09994821
67MP0005167_abnormal_blood-brain_barrier1.09725713
68MP0005551_abnormal_eye_electrophysiolog1.08193151
69MP0001299_abnormal_eye_distance/1.07211922
70MP0002909_abnormal_adrenal_gland1.06231914
71MP0002752_abnormal_somatic_nervous1.05226002
72MP0005058_abnormal_lysosome_morphology1.04889585
73MP0000604_amyloidosis1.04859621
74MP0000579_abnormal_nail_morphology1.04241598
75MP0000467_abnormal_esophagus_morphology1.03680216
76MP0000762_abnormal_tongue_morphology1.02086676
77MP0000647_abnormal_sebaceous_gland1.00029010
78MP0002067_abnormal_sensory_capabilities0.99895471
79MP0002733_abnormal_thermal_nociception0.98377594
80MP0008260_abnormal_autophagy0.98099495
81MP0003283_abnormal_digestive_organ0.96587613
82MP0004145_abnormal_muscle_electrophysio0.96548472
83MP0004264_abnormal_extraembryonic_tissu0.96398054
84MP0004133_heterotaxia0.95402952
85MP0002152_abnormal_brain_morphology0.94508702
86MP0003938_abnormal_ear_development0.94504297
87MP0004381_abnormal_hair_follicle0.93838984
88MP0006276_abnormal_autonomic_nervous0.93441209
89MP0002653_abnormal_ependyma_morphology0.92860693
90MP0001177_atelectasis0.92346695
91MP0004185_abnormal_adipocyte_glucose0.92057041
92MP0006072_abnormal_retinal_apoptosis0.91342471
93MP0003122_maternal_imprinting0.90196037
94MP0000003_abnormal_adipose_tissue0.86111565
95MP0002876_abnormal_thyroid_physiology0.85119511
96MP0009780_abnormal_chondrocyte_physiolo0.82990850
97MP0005195_abnormal_posterior_eye0.78742459
98MP0002638_abnormal_pupillary_reflex0.77898021
99MP0003137_abnormal_impulse_conducting0.77669686
100MP0000631_abnormal_neuroendocrine_gland0.77362408
101MP0001661_extended_life_span0.77190814
102MP0003861_abnormal_nervous_system0.74391482
103MP0004858_abnormal_nervous_system0.74126383
104MP0004147_increased_porphyrin_level0.74011058
105MP0002295_abnormal_pulmonary_circulatio0.73418940
106MP0002069_abnormal_eating/drinking_beha0.72982310
107MP0008872_abnormal_physiological_respon0.71016292
108MP0000026_abnormal_inner_ear0.70010035
109MP0001664_abnormal_digestion0.68305225
110MP0004272_abnormal_basement_membrane0.66390874
111MP0002796_impaired_skin_barrier0.66076963
112MP0000569_abnormal_digit_pigmentation0.65990208
113MP0004811_abnormal_neuron_physiology0.65276438
114MP0003045_fibrosis0.64284877
115MP0005645_abnormal_hypothalamus_physiol0.63298547
116MP0001765_abnormal_ion_homeostasis0.62528844
117MP0005670_abnormal_white_adipose0.62340360
118MP0005253_abnormal_eye_physiology0.62306177
119MP0002557_abnormal_social/conspecific_i0.62122555
120MP0010234_abnormal_vibrissa_follicle0.61738506
121MP0001348_abnormal_lacrimal_gland0.61708167
122MP0001986_abnormal_taste_sensitivity0.60472727
123MP0003453_abnormal_keratinocyte_physiol0.60248273
124MP0002184_abnormal_innervation0.58637593
125MP0003698_abnormal_male_reproductive0.58293722
126MP0010769_abnormal_survival0.58085662
127MP0005377_hearing/vestibular/ear_phenot0.57768730
128MP0003878_abnormal_ear_physiology0.57768730
129MP0000613_abnormal_salivary_gland0.57444987
130MP0000639_abnormal_adrenal_gland0.56036025
131MP0002082_postnatal_lethality0.56019737
132MP0010770_preweaning_lethality0.56019737
133MP0003183_abnormal_peptide_metabolism0.55036266

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.35119245
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.35119245
3Neurofibrillary tangles (HP:0002185)5.86510634
4Abnormality of the corticospinal tract (HP:0002492)5.00279756
5Focal seizures (HP:0007359)4.86728220
6Sensory axonal neuropathy (HP:0003390)4.45822056
7Peripheral hypomyelination (HP:0007182)4.43376516
8Cerebral inclusion bodies (HP:0100314)4.37666842
9Epileptic encephalopathy (HP:0200134)4.33588611
10Cerebral hypomyelination (HP:0006808)4.31295758
11Febrile seizures (HP:0002373)4.17759475
12Parakeratosis (HP:0001036)4.11882095
13Onion bulb formation (HP:0003383)4.00435324
14Abnormal auditory evoked potentials (HP:0006958)3.91893644
15Supranuclear gaze palsy (HP:0000605)3.87908254
16Spastic gait (HP:0002064)3.74624170
17Termporal pattern (HP:0011008)3.58939533
18Insidious onset (HP:0003587)3.58939533
19Intention tremor (HP:0002080)3.55247253
20Ankle clonus (HP:0011448)3.52998486
21Abnormality of binocular vision (HP:0011514)3.51891143
22Diplopia (HP:0000651)3.51891143
23Atonic seizures (HP:0010819)3.46384711
24Alacrima (HP:0000522)3.41270410
25Myokymia (HP:0002411)3.35823940
26Dysmetria (HP:0001310)3.34839605
27Progressive cerebellar ataxia (HP:0002073)3.31662372
28Anteriorly placed anus (HP:0001545)3.24213306
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.14060255
30Generalized tonic-clonic seizures (HP:0002069)3.13716116
31Scanning speech (HP:0002168)3.09319883
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87491250
33Slow saccadic eye movements (HP:0000514)2.86453978
34Postural instability (HP:0002172)2.82018519
35Dialeptic seizures (HP:0011146)2.80429822
36Morphological abnormality of the inner ear (HP:0011390)2.75387782
37Bronchomalacia (HP:0002780)2.73327216
38CNS hypomyelination (HP:0003429)2.71088477
39Decreased lacrimation (HP:0000633)2.70836615
40Hemiparesis (HP:0001269)2.69505891
41Obstructive sleep apnea (HP:0002870)2.68582160
42Clumsiness (HP:0002312)2.65987867
43Absence seizures (HP:0002121)2.62765605
44Segmental peripheral demyelination/remyelination (HP:0003481)2.61118318
45Abnormal eating behavior (HP:0100738)2.59702058
46Spastic paraparesis (HP:0002313)2.54624048
47Esophageal atresia (HP:0002032)2.53239137
48Thickened helices (HP:0000391)2.52714354
49Status epilepticus (HP:0002133)2.51832888
50Absent septum pellucidum (HP:0001331)2.50946747
51Impaired vibration sensation in the lower limbs (HP:0002166)2.50875609
52Congenital ichthyosiform erythroderma (HP:0007431)2.50585423
53Limb dystonia (HP:0002451)2.49768860
54Gaze-evoked nystagmus (HP:0000640)2.46181895
55Epileptiform EEG discharges (HP:0011182)2.45311153
56Truncal ataxia (HP:0002078)2.44822844
57Autoamputation (HP:0001218)2.44726333
58Hyperventilation (HP:0002883)2.44448751
59Spastic tetraparesis (HP:0001285)2.44164700
60Broad-based gait (HP:0002136)2.41806616
61Aplasia involving bones of the upper limbs (HP:0009823)2.41610356
62Aplasia of the phalanges of the hand (HP:0009802)2.41610356
63Aplasia involving bones of the extremities (HP:0009825)2.41610356
64Visual hallucinations (HP:0002367)2.41399874
65Stridor (HP:0010307)2.38495415
66Akinesia (HP:0002304)2.37792156
67Hypoplastic pelvis (HP:0008839)2.36979973
68Lower limb muscle weakness (HP:0007340)2.36757089
69Metabolic alkalosis (HP:0200114)2.32235501
70Premature skin wrinkling (HP:0100678)2.29897255
71Decreased motor nerve conduction velocity (HP:0003431)2.28917251
72Clonus (HP:0002169)2.25980167
73Genetic anticipation (HP:0003743)2.25223739
74Retinal dysplasia (HP:0007973)2.25064479
75Abnormality of the salivary glands (HP:0010286)2.24881360
76Increased circulating renin level (HP:0000848)2.24035861
77Leukodystrophy (HP:0002415)2.22767643
78Urinary urgency (HP:0000012)2.19973230
79Megalencephaly (HP:0001355)2.17998520
80Coronal craniosynostosis (HP:0004440)2.17567100
81Sleep apnea (HP:0010535)2.17290062
82EEG with generalized epileptiform discharges (HP:0011198)2.16633874
83Poor eye contact (HP:0000817)2.16164329
84Impaired smooth pursuit (HP:0007772)2.15728250
85Torticollis (HP:0000473)2.14169180
86Hemiplegia (HP:0002301)2.12820850
87Foot dorsiflexor weakness (HP:0009027)2.11734637
88Bundle branch block (HP:0011710)2.11602456
89Muscle fiber splitting (HP:0003555)2.10011549
90Split foot (HP:0001839)2.09719258
91Pheochromocytoma (HP:0002666)2.09685039
92Bowel incontinence (HP:0002607)2.08961583
93Hypoplasia of the iris (HP:0007676)2.08759529
94Hyporeflexia of lower limbs (HP:0002600)2.08429895
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07198139
96Anxiety (HP:0000739)2.06948017
97Action tremor (HP:0002345)2.06376859
98Hypokalemic alkalosis (HP:0001949)2.04922191
99Abnormality of the septum pellucidum (HP:0007375)2.04617319
100Impaired social interactions (HP:0000735)2.03698769
101Abnormal social behavior (HP:0012433)2.03698769
102Hypsarrhythmia (HP:0002521)2.03659646
103Distal sensory impairment (HP:0002936)2.01290204
104Abnormality of the periventricular white matter (HP:0002518)1.99893366
105Gowers sign (HP:0003391)1.98227903
106Morphological abnormality of the pyramidal tract (HP:0002062)1.98141576
107Ileus (HP:0002595)1.96652189
108Papilledema (HP:0001085)1.95347259
109Partial duplication of thumb phalanx (HP:0009944)1.95076989
110Impaired vibratory sensation (HP:0002495)1.93366017
111Abnormality of the foot musculature (HP:0001436)1.92935958
112Axonal loss (HP:0003447)1.92098746
113Abnormal large intestine physiology (HP:0012700)1.91947620
114Hammertoe (HP:0001765)1.91641166
115Abnormality of glycolysis (HP:0004366)1.91323221
116Increased serum pyruvate (HP:0003542)1.91323221
117Hyperaldosteronism (HP:0000859)1.90628370
118Annular pancreas (HP:0001734)1.90167410
119Dysmetric saccades (HP:0000641)1.88996768
120Absent speech (HP:0001344)1.88872984
121Choreoathetosis (HP:0001266)1.88762530
122Stenosis of the external auditory canal (HP:0000402)1.88251004
123Cerebral hemorrhage (HP:0001342)1.87413198
124Bradykinesia (HP:0002067)1.86977145
125Partial agenesis of the corpus callosum (HP:0001338)1.86858207
126Urinary incontinence (HP:0000020)1.84594096
127Abnormality of renin-angiotensin system (HP:0000847)1.84441243
128Abnormality of the middle phalanges of the toes (HP:0010183)1.84439517
129Abnormality of ocular smooth pursuit (HP:0000617)1.82849819
130Hypomagnesemia (HP:0002917)1.82017091
131Confusion (HP:0001289)1.81197748
132Paraplegia (HP:0010550)1.79982577
133Drooling (HP:0002307)1.78812279
134Paraparesis (HP:0002385)1.78546018
135Tetraplegia (HP:0002445)1.78091428
136Depression (HP:0000716)1.77809842
137Difficulty running (HP:0009046)1.77211798
138Relative macrocephaly (HP:0004482)1.76672434
139Insomnia (HP:0100785)1.76199095
140Abnormality of cochlea (HP:0000375)1.75703434
141Poor speech (HP:0002465)1.75244343
142Amblyopia (HP:0000646)1.75216071
143Neuroendocrine neoplasm (HP:0100634)1.74157360
144Overriding aorta (HP:0002623)1.73015718
145Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.72979158
146Rigidity (HP:0002063)1.72761005
147Synostosis involving the elbow (HP:0003938)1.71930021
148Humeroradial synostosis (HP:0003041)1.71930021
149Dysdiadochokinesis (HP:0002075)1.71125655
150Neuronal loss in central nervous system (HP:0002529)1.70350324
151Infantile muscular hypotonia (HP:0008947)1.70091978
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68612186
153Cupped ear (HP:0000378)1.67978666
154Spastic paraplegia (HP:0001258)1.67686735
155Focal motor seizures (HP:0011153)1.67065923
156Urinary bladder sphincter dysfunction (HP:0002839)1.64584337
157Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64385295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.14259846
2OXSR14.63558524
3DAPK23.09732058
4EPHB13.04310629
5BCR2.85787591
6MET2.82465965
7CDK192.62866088
8WNK12.44364882
9WNK42.34103772
10PKN12.16095082
11CASK2.16047803
12FGFR22.15330123
13MAPKAPK52.12845001
14MINK12.08018290
15ICK1.99909553
16PBK1.98449225
17PNCK1.94260179
18NTRK11.92643565
19LIMK11.90889155
20CAMKK11.89774818
21MST41.86675372
22UHMK11.84955882
23TESK21.78933230
24NEK61.70887890
25RIPK11.59600678
26TYRO31.59237978
27CSNK1A1L1.59173188
28PAK61.58187068
29CSNK1G31.57352903
30CAMK1D1.57063102
31CAMK2B1.55288655
32EPHA41.54650339
33KSR21.42988932
34MAPK131.42491463
35ROCK21.40563509
36CAMK2D1.31879358
37CAMK11.27969232
38SGK21.27764661
39FGR1.25588791
40CSNK1G11.24007764
41CSNK1G21.23288686
42MAP3K21.19946018
43TNIK1.15554103
44CLK11.07950527
45SGK2231.06852704
46SGK4941.06852704
47PRKCG1.06648691
48CAMK2G1.03276253
49LATS21.03074967
50STK381.02861992
51PLK21.00773552
52MAP3K90.99455547
53SGK10.98478665
54TNK20.98427266
55PAK30.96886574
56SGK30.96243974
57PRKD30.95626720
58MARK20.93422383
59CDK140.90121201
60PRPF4B0.90079671
61MAP2K20.88558887
62CDK50.87750017
63DYRK1A0.86681507
64CDK150.85801227
65DAPK10.83845690
66AKT30.82229449
67DDR20.80547502
68CDK180.79520317
69CDK11A0.77512916
70PDPK10.74317833
71PRKD10.73251988
72CAMK2A0.71006194
73EPHA20.70769178
74RPS6KA30.70046602
75GRK50.69650964
76ARAF0.66778674
77PRKCQ0.64925370
78MAPK150.63964360
79TRPM70.61560805
80MARK10.61538078
81EEF2K0.61020199
82BMX0.60121996
83PRKCZ0.59076536
84CAMK40.58680175
85STK110.58458338
86DMPK0.57368051
87FRK0.57119497
88RIPK40.56170339
89TRIB30.55607894
90SIK20.55493866
91DYRK20.54753993
92CSNK1D0.54477109
93MAP3K130.52777335
94FYN0.51285761
95NTRK20.50200714
96MELK0.49544938
97PIK3CA0.49238250
98PHKG10.48501083
99PHKG20.48501083
100WNK30.48330724
101PRKCE0.48096132
102PINK10.48005669
103PAK10.45437806
104LMTK20.45377335
105GSK3B0.44216454
106ERBB40.44146849
107CSNK1A10.44099607
108ACVR1B0.43460808
109CSNK1E0.42974815
110CAMKK20.42398436
111MAPK120.42262712
112PRKACB0.38924187
113MAP2K40.38438258
114CAMK1G0.38050882
115PRKAA10.37379225
116MST1R0.36391287
117PRKCA0.36068289
118PDGFRB0.35865600
119PDK10.35802075
120MAPK100.35789244
121STK38L0.35499503
122NME10.34833623
123MUSK0.34219051
124GSK3A0.34102590
125PRKG10.34004835
126NTRK30.33997640
127INSRR0.32559150
128PRKCH0.31805140
129CDC42BPA0.31789903
130ALK0.30198844
131RET0.29872453
132PTK20.29861238
133RPS6KA50.29136485
134ERBB20.28628045
135MAP3K40.27522264
136BMPR1B0.23360833

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.79547051
2Fatty acid elongation_Homo sapiens_hsa000623.91495071
3Steroid biosynthesis_Homo sapiens_hsa001003.77657577
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.00912182
5Ether lipid metabolism_Homo sapiens_hsa005652.88388981
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86161930
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.69622862
8Vitamin B6 metabolism_Homo sapiens_hsa007502.19285447
9Nitrogen metabolism_Homo sapiens_hsa009102.17536750
10Sulfur metabolism_Homo sapiens_hsa009202.03400223
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02647193
12Sphingolipid metabolism_Homo sapiens_hsa006001.86521303
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84919465
14Axon guidance_Homo sapiens_hsa043601.75668434
15Tight junction_Homo sapiens_hsa045301.72307998
16GABAergic synapse_Homo sapiens_hsa047271.57341479
17Histidine metabolism_Homo sapiens_hsa003401.54132700
18Linoleic acid metabolism_Homo sapiens_hsa005911.48211993
19Protein export_Homo sapiens_hsa030601.44753950
20Glutamatergic synapse_Homo sapiens_hsa047241.41992354
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41707150
22beta-Alanine metabolism_Homo sapiens_hsa004101.40479449
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40312022
24Mineral absorption_Homo sapiens_hsa049781.37502037
25Butanoate metabolism_Homo sapiens_hsa006501.30402087
26Dorso-ventral axis formation_Homo sapiens_hsa043201.28101147
27Arginine and proline metabolism_Homo sapiens_hsa003301.27718997
28Calcium signaling pathway_Homo sapiens_hsa040201.26055102
29Serotonergic synapse_Homo sapiens_hsa047261.23500568
30Renal cell carcinoma_Homo sapiens_hsa052111.23442037
31Long-term depression_Homo sapiens_hsa047301.21496775
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19997502
33Oxytocin signaling pathway_Homo sapiens_hsa049211.15472880
34Cocaine addiction_Homo sapiens_hsa050301.15470517
35Morphine addiction_Homo sapiens_hsa050321.12501237
36Estrogen signaling pathway_Homo sapiens_hsa049151.11812026
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10433576
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09896659
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.07393433
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06927610
41Vibrio cholerae infection_Homo sapiens_hsa051101.05303950
42Arginine biosynthesis_Homo sapiens_hsa002201.04379921
43Endocytosis_Homo sapiens_hsa041441.02978785
44Gastric acid secretion_Homo sapiens_hsa049711.02054395
45Salivary secretion_Homo sapiens_hsa049701.01690409
46Circadian entrainment_Homo sapiens_hsa047130.95966216
47GnRH signaling pathway_Homo sapiens_hsa049120.95766513
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.91911130
49ABC transporters_Homo sapiens_hsa020100.89585534
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89418170
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89183087
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87483694
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87464592
54ErbB signaling pathway_Homo sapiens_hsa040120.85885178
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85880934
56Dopaminergic synapse_Homo sapiens_hsa047280.85237356
57Oxidative phosphorylation_Homo sapiens_hsa001900.83790605
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.83224973
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83010928
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82637234
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81742678
62Hedgehog signaling pathway_Homo sapiens_hsa043400.79793402
63Glutathione metabolism_Homo sapiens_hsa004800.76659547
64Hippo signaling pathway_Homo sapiens_hsa043900.76500190
65Pancreatic secretion_Homo sapiens_hsa049720.76479324
66Gap junction_Homo sapiens_hsa045400.76126467
67Ras signaling pathway_Homo sapiens_hsa040140.75251218
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75176979
69Synaptic vesicle cycle_Homo sapiens_hsa047210.74307727
70Folate biosynthesis_Homo sapiens_hsa007900.71980987
71Cholinergic synapse_Homo sapiens_hsa047250.70791440
72Vitamin digestion and absorption_Homo sapiens_hsa049770.70535587
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69864461
74Circadian rhythm_Homo sapiens_hsa047100.69209685
75Glucagon signaling pathway_Homo sapiens_hsa049220.66712972
76Alzheimers disease_Homo sapiens_hsa050100.66175862
77Phototransduction_Homo sapiens_hsa047440.66080567
78Glioma_Homo sapiens_hsa052140.65563943
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65282953
80Ovarian steroidogenesis_Homo sapiens_hsa049130.64625276
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64555757
82Collecting duct acid secretion_Homo sapiens_hsa049660.64516834
83Choline metabolism in cancer_Homo sapiens_hsa052310.63984569
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63934014
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.63422413
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63325488
87Nicotine addiction_Homo sapiens_hsa050330.62196839
88Arachidonic acid metabolism_Homo sapiens_hsa005900.61817124
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60620159
90Lysosome_Homo sapiens_hsa041420.60482441
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60216155
92Oocyte meiosis_Homo sapiens_hsa041140.60198384
93Amphetamine addiction_Homo sapiens_hsa050310.59527291
94Type II diabetes mellitus_Homo sapiens_hsa049300.59222480
95Cardiac muscle contraction_Homo sapiens_hsa042600.57555936
96Inositol phosphate metabolism_Homo sapiens_hsa005620.57064555
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56652129
98Taste transduction_Homo sapiens_hsa047420.54558630
99Long-term potentiation_Homo sapiens_hsa047200.54436106
100Parkinsons disease_Homo sapiens_hsa050120.52434470
101Insulin secretion_Homo sapiens_hsa049110.52141413
102cAMP signaling pathway_Homo sapiens_hsa040240.52084690
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50591193
104Renin secretion_Homo sapiens_hsa049240.49666630
105Fatty acid biosynthesis_Homo sapiens_hsa000610.49123812
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48982184
107Melanogenesis_Homo sapiens_hsa049160.47029743
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46775541
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45806779
110Prion diseases_Homo sapiens_hsa050200.45604329
111MAPK signaling pathway_Homo sapiens_hsa040100.45204484
112Fatty acid metabolism_Homo sapiens_hsa012120.44982473
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44387139
114PPAR signaling pathway_Homo sapiens_hsa033200.44046136
115AMPK signaling pathway_Homo sapiens_hsa041520.43498238
116Alcoholism_Homo sapiens_hsa050340.43288481
117Bile secretion_Homo sapiens_hsa049760.43115228
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42844739
119Olfactory transduction_Homo sapiens_hsa047400.39697837
120Wnt signaling pathway_Homo sapiens_hsa043100.39454123
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39117132
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38816576
123Thyroid hormone synthesis_Homo sapiens_hsa049180.38539062
124ECM-receptor interaction_Homo sapiens_hsa045120.37906928
125Basal cell carcinoma_Homo sapiens_hsa052170.36574183
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36270203
127Protein digestion and absorption_Homo sapiens_hsa049740.36047274
128Phenylalanine metabolism_Homo sapiens_hsa003600.35212734
129Fat digestion and absorption_Homo sapiens_hsa049750.34652699
130Rap1 signaling pathway_Homo sapiens_hsa040150.34437718
131Glycerolipid metabolism_Homo sapiens_hsa005610.33561589

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