PLEKHH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)4.94976488
2bone trabecula formation (GO:0060346)4.61721111
3glomerular visceral epithelial cell development (GO:0072015)4.50293079
4collagen fibril organization (GO:0030199)4.41839299
5regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.34833512
6mesenchymal-epithelial cell signaling (GO:0060638)4.31227855
7sequestering of extracellular ligand from receptor (GO:0035581)4.18634869
8glomerular epithelial cell development (GO:0072310)4.11240092
9chondrocyte proliferation (GO:0035988)4.05098876
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.01171063
11axon extension involved in axon guidance (GO:0048846)4.01171063
12lateral sprouting from an epithelium (GO:0060601)3.93045965
13kidney morphogenesis (GO:0060993)3.83511586
14protein heterotrimerization (GO:0070208)3.79257862
15craniofacial suture morphogenesis (GO:0097094)3.71138738
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67191441
17metanephric mesenchyme development (GO:0072075)3.56307969
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.55360482
19cell proliferation involved in kidney development (GO:0072111)3.55029108
20cell proliferation involved in metanephros development (GO:0072203)3.52839325
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51855250
22branching involved in salivary gland morphogenesis (GO:0060445)3.47628544
23regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.45890335
24hippo signaling (GO:0035329)3.43623628
25negative regulation of chondrocyte differentiation (GO:0032331)3.42887364
26paraxial mesoderm development (GO:0048339)3.42190356
27kidney mesenchyme development (GO:0072074)3.37739116
28inner ear receptor stereocilium organization (GO:0060122)3.33241756
29righting reflex (GO:0060013)3.31708121
30reflex (GO:0060004)3.31707683
31retina vasculature morphogenesis in camera-type eye (GO:0061299)3.27875272
32nonmotile primary cilium assembly (GO:0035058)3.26517070
33endodermal cell differentiation (GO:0035987)3.23738908
34chondrocyte development (GO:0002063)3.17449276
35mesenchymal cell proliferation (GO:0010463)3.15160503
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13724095
37regulation of hippo signaling (GO:0035330)3.13373658
38lung vasculature development (GO:0060426)3.13183871
39prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.12963195
40positive regulation of mesenchymal cell proliferation (GO:0002053)3.12310792
41regulation of male gonad development (GO:2000018)3.10698560
42neural tube formation (GO:0001841)3.08638964
43auditory receptor cell stereocilium organization (GO:0060088)3.05969441
44mesodermal cell differentiation (GO:0048333)3.03976516
45regulation of mesenchymal cell proliferation (GO:0010464)3.03314733
46smooth muscle tissue development (GO:0048745)3.03086496
47embryonic cranial skeleton morphogenesis (GO:0048701)3.01745098
48startle response (GO:0001964)3.01721295
49positive regulation of male gonad development (GO:2000020)2.99748918
50renal system development (GO:0072001)2.96836672
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.96602398
52regulation of non-canonical Wnt signaling pathway (GO:2000050)2.94832543
53response to pheromone (GO:0019236)2.89899262
54endocardial cushion development (GO:0003197)2.89197251
55cranial suture morphogenesis (GO:0060363)2.87058141
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85845282
57indolalkylamine metabolic process (GO:0006586)2.84207430
58collagen metabolic process (GO:0032963)2.83659673
59somite development (GO:0061053)2.82685858
60negative regulation of cartilage development (GO:0061037)2.82450020
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.82440429
62radial glial cell differentiation (GO:0060019)2.82250669
63collagen catabolic process (GO:0030574)2.82250300
64regulation of establishment of planar polarity (GO:0090175)2.82180618
65negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.81075196
66presynaptic membrane assembly (GO:0097105)2.80882376
67negative regulation of axon extension involved in axon guidance (GO:0048843)2.80371509
68cardiac right ventricle morphogenesis (GO:0003215)2.80079345
69photoreceptor cell maintenance (GO:0045494)2.78409877
70cellular response to vitamin D (GO:0071305)2.77770167
71C4-dicarboxylate transport (GO:0015740)2.77605527
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77431066
73dermatan sulfate biosynthetic process (GO:0030208)2.76039287
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74805463
75negative regulation of smooth muscle cell differentiation (GO:0051151)2.73908716
76regulation of axon extension involved in axon guidance (GO:0048841)2.73714090
77gamma-aminobutyric acid transport (GO:0015812)2.73286464
78outer ear morphogenesis (GO:0042473)2.73220161
79axis elongation (GO:0003401)2.73026509
80multicellular organismal macromolecule metabolic process (GO:0044259)2.72851608
81negative regulation of stem cell proliferation (GO:2000647)2.72631917
82type B pancreatic cell development (GO:0003323)2.72429819
83lung lobe morphogenesis (GO:0060463)2.71802421
84artery development (GO:0060840)2.70787890
85basement membrane organization (GO:0071711)2.70722099
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.70217500
87negative regulation of axon guidance (GO:1902668)2.70195519
88detection of light stimulus involved in visual perception (GO:0050908)2.70124533
89detection of light stimulus involved in sensory perception (GO:0050962)2.70124533
90vascular endothelial growth factor signaling pathway (GO:0038084)2.69751930
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69104561
92negative regulation of catenin import into nucleus (GO:0035414)2.69023931
93branching involved in prostate gland morphogenesis (GO:0060442)2.68787336
94positive regulation of smoothened signaling pathway (GO:0045880)2.68431896
95behavioral response to nicotine (GO:0035095)2.68312716
96mesenchymal cell differentiation (GO:0048762)2.68278758
97regulation of axon guidance (GO:1902667)2.67912852
98convergent extension (GO:0060026)2.67396050
99wound healing, spreading of epidermal cells (GO:0035313)2.67001742
100cornea development in camera-type eye (GO:0061303)2.66847962
101lymphangiogenesis (GO:0001946)2.66810430
102cell migration involved in heart development (GO:0060973)2.64610475
103multicellular organismal catabolic process (GO:0044243)2.64246478
104detection of mechanical stimulus involved in sensory perception (GO:0050974)2.63703723
105auditory behavior (GO:0031223)2.63532484
106branch elongation of an epithelium (GO:0060602)2.62941543
107glomerulus development (GO:0032835)2.62764139
108limb bud formation (GO:0060174)2.60609449
109embryonic epithelial tube formation (GO:0001838)2.60349819
110embryonic digestive tract morphogenesis (GO:0048557)2.60085743
111indole-containing compound catabolic process (GO:0042436)2.59816588
112indolalkylamine catabolic process (GO:0046218)2.59816588
113tryptophan catabolic process (GO:0006569)2.59816588
114extracellular regulation of signal transduction (GO:1900115)2.59483048
115extracellular negative regulation of signal transduction (GO:1900116)2.59483048
116negative regulation of systemic arterial blood pressure (GO:0003085)2.59435734
117embryonic skeletal joint morphogenesis (GO:0060272)2.58793075
118regulation of cartilage development (GO:0061035)2.58490170
119fibroblast migration (GO:0010761)2.58056169
120neuronal action potential propagation (GO:0019227)2.58050105
121otic vesicle formation (GO:0030916)2.57816037
122parturition (GO:0007567)2.57274001
123pattern specification involved in kidney development (GO:0061004)2.57167070
124regulation of chondrocyte differentiation (GO:0032330)2.57115683
125notochord development (GO:0030903)2.56864659
126multicellular organismal metabolic process (GO:0044236)2.56428068
127cell adhesion mediated by integrin (GO:0033627)2.56231076
128regulation of morphogenesis of a branching structure (GO:0060688)2.55065981
129mesenchyme development (GO:0060485)2.54894408
130renal tubule morphogenesis (GO:0061333)2.54736347
131lung secretory cell differentiation (GO:0061140)2.54081348
132limb development (GO:0060173)2.52781567
133appendage development (GO:0048736)2.52781567
134negative chemotaxis (GO:0050919)2.52369391
135negative regulation of embryonic development (GO:0045992)2.52345420
136mesenchyme morphogenesis (GO:0072132)2.51360667
137L-fucose catabolic process (GO:0042355)2.51285014
138fucose catabolic process (GO:0019317)2.51285014
139L-fucose metabolic process (GO:0042354)2.51285014
140dorsal/ventral axis specification (GO:0009950)2.51271819
141mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50940258
142axoneme assembly (GO:0035082)2.50717000
143branching involved in ureteric bud morphogenesis (GO:0001658)2.50109918
144cellular response to sterol (GO:0036315)2.49984650
145extracellular matrix disassembly (GO:0022617)2.49547618
146positive regulation of cartilage development (GO:0061036)2.49525685
147cilium morphogenesis (GO:0060271)2.48403088
148renal filtration (GO:0097205)2.48367583
149sympathetic nervous system development (GO:0048485)2.48201218
150mesonephric tubule development (GO:0072164)2.46821571
151face morphogenesis (GO:0060325)2.46385804
152ganglion development (GO:0061548)2.45547919
153heart morphogenesis (GO:0003007)2.45102593
154regulation of metanephros development (GO:0072215)2.44495305
155nephron tubule formation (GO:0072079)2.43320296
156genitalia morphogenesis (GO:0035112)2.42884600
157dermatan sulfate metabolic process (GO:0030205)2.42698839
158epithelial tube formation (GO:0072175)2.42672748
159epithelial cilium movement (GO:0003351)2.42401468
160nephron epithelium morphogenesis (GO:0072088)2.42342092
161nephron tubule morphogenesis (GO:0072078)2.42342092
162prenylation (GO:0097354)2.41036071
163protein prenylation (GO:0018342)2.41036071
164negative regulation of protein localization to cell surface (GO:2000009)2.39128048
165mechanosensory behavior (GO:0007638)2.38230077
166peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.36765411
167regulation of mesenchymal cell apoptotic process (GO:2001053)2.35764223
168regulation of meiosis I (GO:0060631)2.32521842
169spinal cord motor neuron differentiation (GO:0021522)2.31359969
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30128625
171water-soluble vitamin biosynthetic process (GO:0042364)2.29790451
172retinal cone cell development (GO:0046549)2.29382697
173pancreas development (GO:0031016)2.29063544
174regulation of mesoderm development (GO:2000380)2.28253068
175indole-containing compound metabolic process (GO:0042430)2.27672166
176tryptophan metabolic process (GO:0006568)2.27578104
177spinal cord development (GO:0021510)2.26916701
178positive regulation of metanephros development (GO:0072216)2.26412226
179cellular response to BMP stimulus (GO:0071773)2.23187022
180response to BMP (GO:0071772)2.23187022
181respiratory tube development (GO:0030323)2.23017046
182sulfation (GO:0051923)2.22861987
183lung-associated mesenchyme development (GO:0060484)2.22536780
184embryonic foregut morphogenesis (GO:0048617)2.22502880
185pyrimidine nucleobase catabolic process (GO:0006208)2.21247716
186platelet dense granule organization (GO:0060155)2.20361774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.11146207
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.44921883
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45857806
4VDR_22108803_ChIP-Seq_LS180_Human2.43822087
5* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41060503
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.20234299
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.15788467
8GBX2_23144817_ChIP-Seq_PC3_Human2.12625430
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11444123
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.11184485
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.11069645
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08047068
13EWS_26573619_Chip-Seq_HEK293_Human2.01487725
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01385478
15CJUN_26792858_Chip-Seq_BT549_Human1.91694212
16TAF15_26573619_Chip-Seq_HEK293_Human1.86383536
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.82909318
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81581281
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76199835
20TP53_18474530_ChIP-ChIP_U2OS_Human1.75305464
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.74494738
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73281886
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71605430
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67981044
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.66575147
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66121705
27BRD4_25478319_ChIP-Seq_HGPS_Human1.63540064
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62921997
29TP53_16413492_ChIP-PET_HCT116_Human1.62629289
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62393117
31AR_25329375_ChIP-Seq_VCAP_Human1.62173311
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61411400
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61411400
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.60058156
35EZH2_22144423_ChIP-Seq_EOC_Human1.58563040
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58093625
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56730073
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55554796
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55554796
40AHR_22903824_ChIP-Seq_MCF-7_Human1.55423982
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53809462
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51791120
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51571657
44IGF1R_20145208_ChIP-Seq_DFB_Human1.51436727
45* TCF4_23295773_ChIP-Seq_U87_Human1.51187963
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50145764
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50038448
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49293068
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.49096016
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.49010551
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.47598237
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46627910
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.44595863
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44139317
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.43553322
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43038452
57* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42933002
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41823437
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40343921
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39917305
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39275200
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.39162919
63AR_21572438_ChIP-Seq_LNCaP_Human1.37710924
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.37615465
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36759303
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.34888216
67TCF4_22108803_ChIP-Seq_LS180_Human1.34053384
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32638591
69RUNX2_22187159_ChIP-Seq_PCA_Human1.32273676
70RNF2_27304074_Chip-Seq_NSC_Mouse1.30501017
71SMAD4_21799915_ChIP-Seq_A2780_Human1.30392352
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29940282
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29940282
74* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29566658
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29368385
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29246511
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28026876
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27567202
79CBP_20019798_ChIP-Seq_JUKART_Human1.27567202
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25811233
81FUS_26573619_Chip-Seq_HEK293_Human1.25773633
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.24944543
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23752422
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23153161
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22955182
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.21246591
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20591090
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20531997
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19590691
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19513749
91KDM2B_26808549_Chip-Seq_REH_Human1.18652562
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18366747
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17493809
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16868342
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16783791
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16662925
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16484726
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16261636
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.15579459
100* ESR1_21235772_ChIP-Seq_MCF-7_Human1.15346388
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15289597
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15260641
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.15112867
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14254757
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14239308
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13909453
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.13881983
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13724019
109ZNF274_21170338_ChIP-Seq_K562_Hela1.13370340
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13316972
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.13207180
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12572717
113CDX2_22108803_ChIP-Seq_LS180_Human1.12145398
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10945013
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10042181
116P300_19829295_ChIP-Seq_ESCs_Human1.09965598
117POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09607872
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08674614
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.07857482
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07237084
121ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07054150
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06680886
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06478817
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06068168
125* TCF4_18268006_ChIP-ChIP_LS174T_Human1.05929949
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05873449
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05507774
128STAT3_23295773_ChIP-Seq_U87_Human1.04629801
129* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04498603
130* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04067095
131RXR_22108803_ChIP-Seq_LS180_Human1.02462944
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02039696
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01191898
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00420521
135ER_23166858_ChIP-Seq_MCF-7_Human1.00004098
136BCAT_22108803_ChIP-Seq_LS180_Human0.99914250
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98184658
138DROSHA_22980978_ChIP-Seq_HELA_Human0.97944254
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.97626055
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.96980457
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96490909
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95423356
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95171779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.23780877
2MP0005503_abnormal_tendon_morphology5.13878691
3MP0004272_abnormal_basement_membrane3.40239792
4MP0005275_abnormal_skin_tensile3.16517656
5MP0005623_abnormal_meninges_morphology3.04710641
6MP0010030_abnormal_orbit_morphology2.50081681
7MP0002736_abnormal_nociception_after2.44316600
8MP0003136_yellow_coat_color2.38051560
9MP0003195_calcinosis2.29203273
10MP0001299_abnormal_eye_distance/2.28324770
11MP0009250_abnormal_appendicular_skeleto2.25748913
12MP0002102_abnormal_ear_morphology2.24386062
13MP0003385_abnormal_body_wall2.20435333
14MP0005508_abnormal_skeleton_morphology2.15050632
15MP0002108_abnormal_muscle_morphology2.14786164
16MP0003279_aneurysm2.10546623
17MP0001968_abnormal_touch/_nociception2.10419941
18MP0003705_abnormal_hypodermis_morpholog2.05618853
19MP0008995_early_reproductive_senescence2.05110628
20MP0001958_emphysema2.03602693
21MP0005257_abnormal_intraocular_pressure1.96302839
22MP0000566_synostosis1.95539002
23MP0002282_abnormal_trachea_morphology1.93770125
24MP0003283_abnormal_digestive_organ1.93579072
25MP0005551_abnormal_eye_electrophysiolog1.93276782
26MP0003942_abnormal_urinary_system1.92650946
27MP0002938_white_spotting1.84476791
28MP0003941_abnormal_skin_development1.80764086
29MP0009384_cardiac_valve_regurgitation1.80255082
30MP0000428_abnormal_craniofacial_morphol1.72983702
31MP0004885_abnormal_endolymph1.67618951
32MP0009780_abnormal_chondrocyte_physiolo1.67191480
33MP0000049_abnormal_middle_ear1.66606315
34MP0000534_abnormal_ureter_morphology1.64999751
35MP0001986_abnormal_taste_sensitivity1.64086926
36MP0010368_abnormal_lymphatic_system1.61382200
37MP0000733_abnormal_muscle_development1.61059605
38MP0003937_abnormal_limbs/digits/tail_de1.60568061
39MP0004134_abnormal_chest_morphology1.60342087
40MP0004043_abnormal_pH_regulation1.60084113
41MP0000163_abnormal_cartilage_morphology1.59921424
42MP0003115_abnormal_respiratory_system1.57971189
43MP0002932_abnormal_joint_morphology1.56800423
44MP0002896_abnormal_bone_mineralization1.54440120
45MP0003935_abnormal_craniofacial_develop1.49626283
46MP0000537_abnormal_urethra_morphology1.48769995
47MP0003755_abnormal_palate_morphology1.48011266
48MP0002295_abnormal_pulmonary_circulatio1.46902293
49MP0002116_abnormal_craniofacial_bone1.46115009
50MP0000383_abnormal_hair_follicle1.43768191
51MP0002115_abnormal_skeleton_extremities1.43718761
52MP0005253_abnormal_eye_physiology1.43403289
53MP0003091_abnormal_cell_migration1.43324597
54MP0003122_maternal_imprinting1.39431243
55MP0010386_abnormal_urinary_bladder1.37388677
56MP0008057_abnormal_DNA_replication1.36909477
57MP0000432_abnormal_head_morphology1.36587887
58MP0009053_abnormal_anal_canal1.36269634
59MP0005367_renal/urinary_system_phenotyp1.35222515
60MP0000516_abnormal_urinary_system1.35222515
61MP0000762_abnormal_tongue_morphology1.35059998
62MP0000631_abnormal_neuroendocrine_gland1.31217239
63MP0002109_abnormal_limb_morphology1.29912179
64MP0006054_spinal_hemorrhage1.28470554
65MP0005171_absent_coat_pigmentation1.28108472
66MP0001485_abnormal_pinna_reflex1.26559847
67MP0005646_abnormal_pituitary_gland1.26541447
68MP0005248_abnormal_Harderian_gland1.25697293
69MP0001501_abnormal_sleep_pattern1.25315016
70MP0000013_abnormal_adipose_tissue1.24955147
71MP0001486_abnormal_startle_reflex1.23831454
72MP0009046_muscle_twitch1.23283956
73MP0002249_abnormal_larynx_morphology1.23032088
74MP0002638_abnormal_pupillary_reflex1.22416430
75MP0003566_abnormal_cell_adhesion1.22386350
76MP0000003_abnormal_adipose_tissue1.20241035
77MP0002233_abnormal_nose_morphology1.20022657
78MP0002272_abnormal_nervous_system1.18585631
79MP0006072_abnormal_retinal_apoptosis1.17096681
80MP0005410_abnormal_fertilization1.16022204
81MP0005076_abnormal_cell_differentiation1.15108331
82MP0002113_abnormal_skeleton_development1.14545642
83MP0000427_abnormal_hair_cycle1.14430166
84MP0001293_anophthalmia1.14155572
85MP0001879_abnormal_lymphatic_vessel1.14008982
86MP0003890_abnormal_embryonic-extraembry1.12876994
87MP0000767_abnormal_smooth_muscle1.12122380
88MP0004782_abnormal_surfactant_physiolog1.11256288
89MP0002060_abnormal_skin_morphology1.09465969
90MP0008877_abnormal_DNA_methylation1.09421881
91MP0004215_abnormal_myocardial_fiber1.08182466
92MP0002653_abnormal_ependyma_morphology1.07146835
93MP0002877_abnormal_melanocyte_morpholog1.06761813
94MP0003950_abnormal_plasma_membrane1.06360766
95MP0000462_abnormal_digestive_system1.06204542
96MP0002557_abnormal_social/conspecific_i1.04726930
97MP0002751_abnormal_autonomic_nervous1.03421282
98MP0001177_atelectasis1.02696542
99MP0000026_abnormal_inner_ear1.02284684
100MP0002177_abnormal_outer_ear1.01173459
101MP0005023_abnormal_wound_healing1.00466744
102MP0004085_abnormal_heartbeat1.00429601
103MP0001346_abnormal_lacrimal_gland0.98990999
104MP0002234_abnormal_pharynx_morphology0.98525846
105MP0002697_abnormal_eye_size0.97950320
106MP0001984_abnormal_olfaction0.97306451
107MP0002733_abnormal_thermal_nociception0.97189342
108MP0002876_abnormal_thyroid_physiology0.97085485
109MP0008775_abnormal_heart_ventricle0.97013536
110MP0005195_abnormal_posterior_eye0.96959365
111MP0002138_abnormal_hepatobiliary_system0.95793422
112MP0000751_myopathy0.95508731
113MP0000569_abnormal_digit_pigmentation0.95282354
114MP0003252_abnormal_bile_duct0.95116317
115MP0009745_abnormal_behavioral_response0.94976075
116MP0002168_other_aberrant_phenotype0.94803133
117MP0002114_abnormal_axial_skeleton0.94472266
118MP0010678_abnormal_skin_adnexa0.94141031
119MP0003045_fibrosis0.94099753
120MP0000639_abnormal_adrenal_gland0.93479903
121MP0003137_abnormal_impulse_conducting0.92710886
122MP0004742_abnormal_vestibular_system0.92513985
123MP0000372_irregular_coat_pigmentation0.92330168
124MP0005390_skeleton_phenotype0.91162388
125MP0000647_abnormal_sebaceous_gland0.89746106
126MP0000230_abnormal_systemic_arterial0.89568662
127MP0002752_abnormal_somatic_nervous0.89029191
128MP0002925_abnormal_cardiovascular_devel0.88441374
129MP0002160_abnormal_reproductive_system0.87741272
130MP0003936_abnormal_reproductive_system0.87436827
131MP0001175_abnormal_lung_morphology0.87013562
132MP0001243_abnormal_dermal_layer0.86499828
133MP0003011_delayed_dark_adaptation0.86056795
134MP0001270_distended_abdomen0.85670913
135MP0001664_abnormal_digestion0.85451333
136MP0005595_abnormal_vascular_smooth0.85417202
137MP0002254_reproductive_system_inflammat0.84903715
138MP0005174_abnormal_tail_pigmentation0.84654430
139MP0001756_abnormal_urination0.84554148
140MP0002111_abnormal_tail_morphology0.83995116
141MP0003121_genomic_imprinting0.83687799
142MP0005187_abnormal_penis_morphology0.83674801
143MP0002067_abnormal_sensory_capabilities0.82580482
144MP0003119_abnormal_digestive_system0.82203711
145MP0001286_abnormal_eye_development0.81793242
146MP0002933_joint_inflammation0.81064967
147MP0002092_abnormal_eye_morphology0.81020884
148MP0002089_abnormal_postnatal_growth/wei0.79926570
149MP0003938_abnormal_ear_development0.76628297
150MP0010352_gastrointestinal_tract_polyps0.76150552
151MP0000579_abnormal_nail_morphology0.76029895
152MP0004197_abnormal_fetal_growth/weight/0.75889002
153MP0004233_abnormal_muscle_weight0.75496902
154MP0005388_respiratory_system_phenotype0.74019122
155MP0002133_abnormal_respiratory_system0.74019122
156MP0001614_abnormal_blood_vessel0.72836497
157MP0001340_abnormal_eyelid_morphology0.72321110
158MP0002128_abnormal_blood_circulation0.72097246

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.57749746
2Premature rupture of membranes (HP:0001788)4.54132942
3Shallow orbits (HP:0000586)4.10842143
4Broad metatarsal (HP:0001783)3.99796285
5Hyperventilation (HP:0002883)3.75287510
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.73351954
7Short 4th metacarpal (HP:0010044)3.73351954
8Ankle contracture (HP:0006466)3.70492295
9True hermaphroditism (HP:0010459)3.55719645
10Pancreatic cysts (HP:0001737)3.30828821
11Abnormality of the renal cortex (HP:0011035)3.22592271
12Bell-shaped thorax (HP:0001591)3.22197859
13Keratoconus (HP:0000563)3.21791443
14Increased corneal curvature (HP:0100692)3.21791443
15Follicular hyperkeratosis (HP:0007502)3.21286663
16Molar tooth sign on MRI (HP:0002419)3.21038630
17Abnormality of midbrain morphology (HP:0002418)3.21038630
18Tubular atrophy (HP:0000092)3.06375840
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.03253030
20Hypoplastic ischia (HP:0003175)3.01843431
21Soft skin (HP:0000977)3.00607653
22Aortic dissection (HP:0002647)2.98648208
23Abnormality of the renal medulla (HP:0100957)2.98203986
24Congenital sensorineural hearing impairment (HP:0008527)2.93829765
25Cervical subluxation (HP:0003308)2.93606589
26Nephronophthisis (HP:0000090)2.92936673
27Atrophic scars (HP:0001075)2.90089548
28Pancreatic fibrosis (HP:0100732)2.87119909
29Abnormality of the parietal bone (HP:0002696)2.86936814
30Midline defect of the nose (HP:0004122)2.86591808
31Mesomelia (HP:0003027)2.74010206
32Neonatal short-limb short stature (HP:0008921)2.70716540
33Abnormality of the 4th metacarpal (HP:0010012)2.69777909
34Abnormality of the ischium (HP:0003174)2.61714945
35Bladder diverticulum (HP:0000015)2.61531598
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60923730
37Congenital stationary night blindness (HP:0007642)2.60472231
38Aortic aneurysm (HP:0004942)2.59043999
39Vitreoretinal degeneration (HP:0000655)2.54374908
40Cutaneous finger syndactyly (HP:0010554)2.53396332
41Trigonocephaly (HP:0000243)2.52987581
42Tubulointerstitial fibrosis (HP:0005576)2.49367954
43Exostoses (HP:0100777)2.47821178
44Short tibia (HP:0005736)2.47028360
45Cerebral aneurysm (HP:0004944)2.43775729
46Abnormality of dentin (HP:0010299)2.41147920
47Abnormality of the renal collecting system (HP:0004742)2.39703074
48Polydipsia (HP:0001959)2.39535400
49Abnormal drinking behavior (HP:0030082)2.39535400
50Tachypnea (HP:0002789)2.38570201
51Flat capital femoral epiphysis (HP:0003370)2.36240499
52Genital tract atresia (HP:0001827)2.33089562
53Tubulointerstitial abnormality (HP:0001969)2.33077395
54Broad long bones (HP:0005622)2.32728734
55Coronal craniosynostosis (HP:0004440)2.32257547
56Vaginal atresia (HP:0000148)2.32136222
57Wrist flexion contracture (HP:0001239)2.32125747
58Spinal rigidity (HP:0003306)2.31428014
59Abnormality of the nasal septum (HP:0000419)2.29729314
60Medial flaring of the eyebrow (HP:0010747)2.27188507
61Hypoplastic labia majora (HP:0000059)2.25143164
62Chronic hepatic failure (HP:0100626)2.24194801
63Large for gestational age (HP:0001520)2.22741768
64Decreased circulating renin level (HP:0003351)2.22613776
65Type 1 muscle fiber predominance (HP:0003803)2.21760947
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.21322849
67Cystic liver disease (HP:0006706)2.21163243
68Abnormality of the pubic bones (HP:0003172)2.20216009
69Shawl scrotum (HP:0000049)2.19545981
70Renal hypoplasia (HP:0000089)2.19468654
71Morphological abnormality of the middle ear (HP:0008609)2.19012895
72Broad phalanx (HP:0006009)2.18990259
73Hip contracture (HP:0003273)2.18640816
74Hemiparesis (HP:0001269)2.18065169
75Male pseudohermaphroditism (HP:0000037)2.13688351
76Stomach cancer (HP:0012126)2.11462231
77Polyuria (HP:0000103)2.11449985
78Wormian bones (HP:0002645)2.09581573
79Absent speech (HP:0001344)2.09059465
80Wide anterior fontanel (HP:0000260)2.08878100
81Genetic anticipation (HP:0003743)2.08790894
82Vascular tortuosity (HP:0004948)2.08040333
83Abnormality of the labia majora (HP:0012881)2.07381563
84Renal cortical cysts (HP:0000803)2.07231298
85Chorioretinal atrophy (HP:0000533)2.06970001
86Facial shape deformation (HP:0011334)2.06226840
87Potter facies (HP:0002009)2.06226840
88Aplasia involving bones of the upper limbs (HP:0009823)2.05930900
89Aplasia of the phalanges of the hand (HP:0009802)2.05930900
90Aplasia involving bones of the extremities (HP:0009825)2.05930900
91Blue sclerae (HP:0000592)2.05884157
92Dilatation of the ascending aorta (HP:0005111)2.05429027
93Broad thumb (HP:0011304)2.04779819
94Limited hip movement (HP:0008800)2.03770277
95Intestinal atresia (HP:0011100)2.02995928
96Bilateral microphthalmos (HP:0007633)2.02304284
97Overgrowth (HP:0001548)2.02208362
98Adactyly (HP:0009776)2.01562188
99Hypoplastic iliac wings (HP:0002866)2.00717149
100Fragile skin (HP:0001030)1.98766673
101Joint laxity (HP:0001388)1.98543957
102Gaze-evoked nystagmus (HP:0000640)1.98231408
103Buphthalmos (HP:0000557)1.98084970
104Broad phalanges of the hand (HP:0009768)1.97852709
105Congenital hepatic fibrosis (HP:0002612)1.97695492
106Broad toe (HP:0001837)1.97488652
107Abnormality of the labia minora (HP:0012880)1.96158261
108Hyperextensible skin (HP:0000974)1.94332193
109Microglossia (HP:0000171)1.92589392
110Bicornuate uterus (HP:0000813)1.92544334
111Arterial tortuosity (HP:0005116)1.92396399
112Anophthalmia (HP:0000528)1.91782194
113Cutaneous syndactyly (HP:0012725)1.91437580
114Broad finger (HP:0001500)1.91316815
115Colon cancer (HP:0003003)1.91183768
116Patellar aplasia (HP:0006443)1.91015599
117Epidermoid cyst (HP:0200040)1.90880343
118Mitral valve prolapse (HP:0001634)1.90362584
119Tubulointerstitial nephritis (HP:0001970)1.89203268
120Cupped ear (HP:0000378)1.87507274
121Stage 5 chronic kidney disease (HP:0003774)1.86706261
122Hypoplastic pelvis (HP:0008839)1.85932466
123Short hallux (HP:0010109)1.85674953
124Narrow palate (HP:0000189)1.85614654
125Submucous cleft hard palate (HP:0000176)1.85465605
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.85026170
127Limited elbow extension (HP:0001377)1.84423352
128Turricephaly (HP:0000262)1.84199236
129Nephrogenic diabetes insipidus (HP:0009806)1.84117954
130Abolished electroretinogram (ERG) (HP:0000550)1.83340416
131Infantile muscular hypotonia (HP:0008947)1.83210619
132Mildly elevated creatine phosphokinase (HP:0008180)1.82564030
133Aplasia/Hypoplasia of the patella (HP:0006498)1.82398388
134Bronchomalacia (HP:0002780)1.81768747
135Slender build (HP:0001533)1.81503458
136Gait imbalance (HP:0002141)1.81224723
137Broad face (HP:0000283)1.81054871
138Progressive cerebellar ataxia (HP:0002073)1.80375072
139Congenital primary aphakia (HP:0007707)1.80032200
140Osteoarthritis (HP:0002758)1.80018880
141Hepatoblastoma (HP:0002884)1.79467475
142Duplicated collecting system (HP:0000081)1.79446757
143Progressive inability to walk (HP:0002505)1.79128344
144Hypothermia (HP:0002045)1.78813180
145Abnormal ossification of hand bones (HP:0005921)1.78729677
146Abnormality of the radial head (HP:0003995)1.76828023
147Genu recurvatum (HP:0002816)1.76597578
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75537611
149Abnormality of the proximal phalanges of the hand (HP:0009834)1.75283087
150Attenuation of retinal blood vessels (HP:0007843)1.74849763
151Abnormal hand bone ossification (HP:0010660)1.74055898
152Protruding ear (HP:0000411)1.74009458
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.73317716
154Short chin (HP:0000331)1.72259416
155Abnormal urine output (HP:0012590)1.72035775
156Neoplasm of the heart (HP:0100544)1.71355370
157Epiphyseal dysplasia (HP:0002656)1.71123465
158Postaxial hand polydactyly (HP:0001162)1.70653306
159Down-sloping shoulders (HP:0200021)1.70523815
160Short ribs (HP:0000773)1.70059068
161Broad hallux (HP:0010055)1.69981970
162Hypoplasia of the maxilla (HP:0000327)1.69696304
163Abnormality of incisor morphology (HP:0011063)1.69189129
164Pulmonary artery stenosis (HP:0004415)1.68637152
165Broad ribs (HP:0000885)1.68117840
166Febrile seizures (HP:0002373)1.67621246
167Decreased lacrimation (HP:0000633)1.67397400
168Aneurysm (HP:0002617)1.67358961
169Tarsal synostosis (HP:0008368)1.67017823
170Short foot (HP:0001773)1.66855604
171Type II lissencephaly (HP:0007260)1.66834910
172Ulnar claw (HP:0001178)1.66175403
173Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.66072505
174Metabolic alkalosis (HP:0200114)1.65686200
175Dislocated radial head (HP:0003083)1.64615783
176Tibial bowing (HP:0002982)1.64526776
177Abnormality of renal excretion (HP:0011036)1.64311071
178Widely spaced teeth (HP:0000687)1.64289546
179Knee flexion contracture (HP:0006380)1.64094984
180Preaxial foot polydactyly (HP:0001841)1.63782795
181Femoral bowing (HP:0002980)1.62992647
182Congenital, generalized hypertrichosis (HP:0004540)1.62986771
183Anteriorly placed anus (HP:0001545)1.62851395
184Absent frontal sinuses (HP:0002688)1.62133821
185Long clavicles (HP:0000890)1.60629813
186Inability to walk (HP:0002540)1.60621774
187Aqueductal stenosis (HP:0002410)1.60137581
188Bifid tongue (HP:0010297)1.59810741
189Decreased skull ossification (HP:0004331)1.59631565
190Deviation of the hallux (HP:0010051)1.59558952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.53201925
2DDR24.19703236
3PRKD32.86323209
4PDGFRA2.68898765
5TTN2.53640283
6FGFR22.44880809
7EPHB22.42987016
8ACVR1B2.41619588
9GRK12.38312770
10WNK32.31178053
11SIK12.20552461
12CAMK1G2.20346650
13FRK1.94814984
14STK31.94383109
15EPHA31.88783342
16STK38L1.88300063
17TIE11.88153720
18NUAK11.87954030
19ADRBK21.84728355
20CAMK1D1.80944778
21DMPK1.79706100
22TNIK1.79505358
23MAPK131.76163005
24WNK11.74831908
25FER1.74276187
26WNK41.63420926
27PAK21.54935493
28ERBB31.53678597
29CSNK1G11.53151308
30PTK2B1.48428021
31TESK11.48367202
32INSRR1.46863812
33BMX1.46086647
34EPHA21.42808893
35FGFR11.41389505
36LATS21.39088636
37MARK11.37749543
38RIPK11.32839700
39CDK121.32609941
40PDGFRB1.31206352
41MAP4K21.29647651
42CSNK1A1L1.29624339
43PINK11.28838850
44TGFBR21.28719048
45PTK21.28629615
46DAPK21.28135023
47MAP3K41.26784905
48CASK1.23046578
49PIK3CA1.22544454
50MET1.21938942
51BRSK21.20799053
52WEE11.19490299
53OXSR11.19070295
54ZAK1.15047976
55PAK31.14094042
56PDK21.14064671
57CSNK1G21.13654208
58PDK31.10736749
59PDK41.10736749
60MTOR1.10031073
61CSNK1G31.09165812
62TRIM281.06855562
63ICK1.06667421
64ROCK11.01533752
65PTK60.99487635
66PAK40.98003732
67PRKCE0.96519955
68NEK60.95899981
69MAPK150.95505676
70EPHB10.95396272
71PRKD20.93630354
72CDC42BPA0.90372273
73MUSK0.89377500
74NTRK30.87831694
75BRD40.81545875
76PLK20.79335624
77RPS6KA40.77415188
78TRPM70.75452793
79TAOK30.74085464
80MKNK20.73725846
81MKNK10.72455508
82PRKCH0.72107235
83PNCK0.70774763
84DYRK20.70227619
85MAP3K20.69441653
86PRKCG0.68023389
87NME10.67141976
88AKT30.65376111
89MAP3K70.65111434
90BCR0.65005029
91STK380.64500649
92MAPKAPK50.64194187
93CAMK2A0.59861704
94STK390.59522750
95TGFBR10.59326171
96DYRK1A0.59085730
97DYRK1B0.56579030
98BMPR1B0.55189074
99TLK10.54497591
100INSR0.54426021
101MARK20.53178826
102MAP2K10.51748068
103PKN10.51581512
104MELK0.51555647
105PLK30.51521101
106PIK3CG0.50127081
107TRIB30.50080740
108CDK60.49968925
109CHUK0.49789531
110ROCK20.49156936
111PRKAA20.49133949
112CSNK1D0.47813477
113MAPK70.47638139
114PRKACA0.47289926
115PASK0.45356005
116MAPK10.44790336
117PRKD10.44388389
118NLK0.44197780
119CAMK2B0.43739309
120GSK3A0.43272403
121SGK30.43123270
122PRKG10.42877370
123GRK50.42447954
124ERBB40.42429160
125NEK90.42261097
126SGK20.41650861
127CAMK2D0.40961352
128ADRBK10.39687082
129ERBB20.38997091
130FGFR30.37897022
131MAPKAPK30.37401809
132SRC0.36976352
133CSNK1A10.36832809
134CAMK40.36183768
135VRK10.35639449
136CAMKK20.34861042
137LMTK20.34826421
138EIF2AK30.33951392
139PRKG20.33374250
140MAP2K70.33159552
141EIF2AK20.33126314
142IGF1R0.32664821
143CDK30.32663214
144PLK40.32215610
145SGK2230.29903944
146SGK4940.29903944
147CDK90.29358633
148MOS0.27433095
149IRAK10.26754987
150MYLK0.26431539

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.77428901
2Basal cell carcinoma_Homo sapiens_hsa052172.85376748
3Hedgehog signaling pathway_Homo sapiens_hsa043402.68389443
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65362335
5Focal adhesion_Homo sapiens_hsa045102.51372229
6Adherens junction_Homo sapiens_hsa045202.46815655
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32274038
8Protein digestion and absorption_Homo sapiens_hsa049742.28445343
9Nitrogen metabolism_Homo sapiens_hsa009102.24233332
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.17029453
11Phototransduction_Homo sapiens_hsa047442.16894246
12Butanoate metabolism_Homo sapiens_hsa006502.15784289
13Tryptophan metabolism_Homo sapiens_hsa003802.07142881
14Hippo signaling pathway_Homo sapiens_hsa043902.01241541
15Proteoglycans in cancer_Homo sapiens_hsa052051.98639984
16Linoleic acid metabolism_Homo sapiens_hsa005911.97161737
17TGF-beta signaling pathway_Homo sapiens_hsa043501.91938148
18Small cell lung cancer_Homo sapiens_hsa052221.87918341
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86971494
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86601482
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83043992
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82825729
23Dilated cardiomyopathy_Homo sapiens_hsa054141.81135687
24Amoebiasis_Homo sapiens_hsa051461.80581835
25ABC transporters_Homo sapiens_hsa020101.75260694
26Wnt signaling pathway_Homo sapiens_hsa043101.68370255
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68275812
28Selenocompound metabolism_Homo sapiens_hsa004501.66850417
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66825341
30Ether lipid metabolism_Homo sapiens_hsa005651.66505746
31Axon guidance_Homo sapiens_hsa043601.63815575
32Nicotine addiction_Homo sapiens_hsa050331.62475756
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56563976
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55023111
35Histidine metabolism_Homo sapiens_hsa003401.53967563
36MicroRNAs in cancer_Homo sapiens_hsa052061.51765703
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51381241
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.50183261
39Prostate cancer_Homo sapiens_hsa052151.49221286
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48453600
41Propanoate metabolism_Homo sapiens_hsa006401.46726042
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45351668
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45350654
44Melanoma_Homo sapiens_hsa052181.44468458
45Bladder cancer_Homo sapiens_hsa052191.38961650
46Pathways in cancer_Homo sapiens_hsa052001.38664122
47Glutamatergic synapse_Homo sapiens_hsa047241.36085373
48beta-Alanine metabolism_Homo sapiens_hsa004101.29966380
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27098987
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25786429
51Fatty acid degradation_Homo sapiens_hsa000711.24140867
52Olfactory transduction_Homo sapiens_hsa047401.24102294
53Chemical carcinogenesis_Homo sapiens_hsa052041.23601286
54Tight junction_Homo sapiens_hsa045301.23562617
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23022171
56Retinol metabolism_Homo sapiens_hsa008301.21701700
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20013896
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.18758097
59Morphine addiction_Homo sapiens_hsa050321.17802443
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17784164
61Serotonergic synapse_Homo sapiens_hsa047261.17291755
62Melanogenesis_Homo sapiens_hsa049161.13760911
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05040350
64Rap1 signaling pathway_Homo sapiens_hsa040151.04447816
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03151035
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02826895
67Dorso-ventral axis formation_Homo sapiens_hsa043200.99922581
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98813505
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97778672
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97265748
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96821881
72Chronic myeloid leukemia_Homo sapiens_hsa052200.96560180
73Notch signaling pathway_Homo sapiens_hsa043300.96430067
74Salivary secretion_Homo sapiens_hsa049700.96231837
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95290382
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.95094255
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93676471
78Glioma_Homo sapiens_hsa052140.93577546
79Malaria_Homo sapiens_hsa051440.92796160
80Glycerolipid metabolism_Homo sapiens_hsa005610.92697877
81Caffeine metabolism_Homo sapiens_hsa002320.90748434
82GABAergic synapse_Homo sapiens_hsa047270.90114565
83Lysine degradation_Homo sapiens_hsa003100.87495894
84Long-term depression_Homo sapiens_hsa047300.84932711
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84497840
86Peroxisome_Homo sapiens_hsa041460.83463531
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83196315
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.83168237
89Vibrio cholerae infection_Homo sapiens_hsa051100.83059209
90Estrogen signaling pathway_Homo sapiens_hsa049150.82753378
91Calcium signaling pathway_Homo sapiens_hsa040200.82633813
92Renal cell carcinoma_Homo sapiens_hsa052110.81926797
93Fanconi anemia pathway_Homo sapiens_hsa034600.81083496
94Viral myocarditis_Homo sapiens_hsa054160.81076116
95HTLV-I infection_Homo sapiens_hsa051660.80184204
96Insulin secretion_Homo sapiens_hsa049110.79980421
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79594641
98Pancreatic cancer_Homo sapiens_hsa052120.79594488
99Toxoplasmosis_Homo sapiens_hsa051450.78945282
100Ovarian steroidogenesis_Homo sapiens_hsa049130.78696581
101Endometrial cancer_Homo sapiens_hsa052130.77285576
102Renin-angiotensin system_Homo sapiens_hsa046140.75129728
103Ras signaling pathway_Homo sapiens_hsa040140.74978255
104Type II diabetes mellitus_Homo sapiens_hsa049300.74316536
105Thyroid hormone synthesis_Homo sapiens_hsa049180.73962447
106cAMP signaling pathway_Homo sapiens_hsa040240.72511172
107PPAR signaling pathway_Homo sapiens_hsa033200.71759093
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.71413673
109Bile secretion_Homo sapiens_hsa049760.70943016
110Colorectal cancer_Homo sapiens_hsa052100.70371727
111Fatty acid elongation_Homo sapiens_hsa000620.70064665
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69181456
113Renin secretion_Homo sapiens_hsa049240.69098431
114Arachidonic acid metabolism_Homo sapiens_hsa005900.68887991
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68676711
116ErbB signaling pathway_Homo sapiens_hsa040120.67770216
117Dopaminergic synapse_Homo sapiens_hsa047280.67769351
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67378455
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67302757
120Gap junction_Homo sapiens_hsa045400.67282672
121MAPK signaling pathway_Homo sapiens_hsa040100.66263705
122Cocaine addiction_Homo sapiens_hsa050300.64363150
123FoxO signaling pathway_Homo sapiens_hsa040680.63601775
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.63410498
125Fatty acid metabolism_Homo sapiens_hsa012120.63106798
126Gastric acid secretion_Homo sapiens_hsa049710.60180224
127TNF signaling pathway_Homo sapiens_hsa046680.60010634
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59930323
129Complement and coagulation cascades_Homo sapiens_hsa046100.59688286
130Sphingolipid metabolism_Homo sapiens_hsa006000.58981239
131Glucagon signaling pathway_Homo sapiens_hsa049220.58598826
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58493758
133Circadian entrainment_Homo sapiens_hsa047130.58044571
134Fat digestion and absorption_Homo sapiens_hsa049750.57572827
135Basal transcription factors_Homo sapiens_hsa030220.56837490
136Phagosome_Homo sapiens_hsa041450.56562898
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.56075274
138Mineral absorption_Homo sapiens_hsa049780.55837378
139Vitamin digestion and absorption_Homo sapiens_hsa049770.53626826
140mTOR signaling pathway_Homo sapiens_hsa041500.52190676
141Homologous recombination_Homo sapiens_hsa034400.51288508
142Steroid biosynthesis_Homo sapiens_hsa001000.50275394
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50082263
144Fatty acid biosynthesis_Homo sapiens_hsa000610.49973565
145Cell cycle_Homo sapiens_hsa041100.49925712
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49794953
147p53 signaling pathway_Homo sapiens_hsa041150.49296768
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49009133
149Amphetamine addiction_Homo sapiens_hsa050310.48872633
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.48210807
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47028000
152Endocytosis_Homo sapiens_hsa041440.46712074
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46104748
154Circadian rhythm_Homo sapiens_hsa047100.44068263
155Platelet activation_Homo sapiens_hsa046110.43881160
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.43393690
157GnRH signaling pathway_Homo sapiens_hsa049120.43142672
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.42781721
159Oxytocin signaling pathway_Homo sapiens_hsa049210.42420433
160Protein export_Homo sapiens_hsa030600.42053576
161Taste transduction_Homo sapiens_hsa047420.41558766
162Hepatitis B_Homo sapiens_hsa051610.41494736
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41343861

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