PLEKHH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.37114890
2hemidesmosome assembly (GO:0031581)4.02259597
3bundle of His cell to Purkinje myocyte communication (GO:0086069)3.75232851
4positive regulation of fatty acid beta-oxidation (GO:0032000)3.73424128
5desmosome organization (GO:0002934)3.68360922
6positive regulation of protein kinase C signaling (GO:0090037)3.62610523
7regulation of fatty acid beta-oxidation (GO:0031998)3.43308542
8positive regulation of fatty acid oxidation (GO:0046321)3.38141069
9regulation of cholesterol homeostasis (GO:2000188)3.30045165
10sarcomere organization (GO:0045214)3.28981382
11regulation of fatty acid oxidation (GO:0046320)3.26620157
12carnitine shuttle (GO:0006853)3.25590692
13establishment of apical/basal cell polarity (GO:0035089)3.23584968
14regulation of p38MAPK cascade (GO:1900744)3.19445645
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13701443
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12117892
17ear development (GO:0043583)3.09926095
18atrioventricular valve morphogenesis (GO:0003181)3.09279535
19fatty acid transmembrane transport (GO:1902001)3.06181763
20establishment of monopolar cell polarity (GO:0061162)3.04498649
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.04498649
22cardiac myofibril assembly (GO:0055003)3.01542347
23polarized epithelial cell differentiation (GO:0030859)3.00664734
24cornea development in camera-type eye (GO:0061303)3.00606363
25actin-myosin filament sliding (GO:0033275)2.97917049
26muscle filament sliding (GO:0030049)2.97917049
27proline biosynthetic process (GO:0006561)2.96064901
28lysine catabolic process (GO:0006554)2.92113735
29lysine metabolic process (GO:0006553)2.92113735
30regulation of sequestering of triglyceride (GO:0010889)2.90653186
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89956734
32skin morphogenesis (GO:0043589)2.89650639
33biotin metabolic process (GO:0006768)2.88935737
34snRNA processing (GO:0016180)2.87717465
35cell-substrate junction assembly (GO:0007044)2.87422618
36regulation of skeletal muscle contraction (GO:0014819)2.86412537
37negative regulation of potassium ion transmembrane transport (GO:1901380)2.86056210
38protein heterotrimerization (GO:0070208)2.85261831
39snRNA metabolic process (GO:0016073)2.85148982
40lung epithelium development (GO:0060428)2.84322110
41ventricular cardiac muscle cell action potential (GO:0086005)2.82433763
42cytoskeletal anchoring at plasma membrane (GO:0007016)2.80861806
434-hydroxyproline metabolic process (GO:0019471)2.78541731
44epithelial cell-cell adhesion (GO:0090136)2.77181014
45cardiac right ventricle morphogenesis (GO:0003215)2.77090063
46cell communication involved in cardiac conduction (GO:0086065)2.76716912
47positive regulation of glycogen biosynthetic process (GO:0045725)2.75656753
48behavioral response to nicotine (GO:0035095)2.74050906
49regulation of translational fidelity (GO:0006450)2.73895141
50positive regulation of p38MAPK cascade (GO:1900745)2.73881626
51low-density lipoprotein particle clearance (GO:0034383)2.71945240
52endothelial cell chemotaxis (GO:0035767)2.71511133
53apoptotic cell clearance (GO:0043277)2.71408105
54regulation of glucose import in response to insulin stimulus (GO:2001273)2.70591892
55negative regulation of fatty acid transport (GO:2000192)2.70277470
56positive regulation of triglyceride biosynthetic process (GO:0010867)2.69444086
57auditory receptor cell stereocilium organization (GO:0060088)2.67690144
58tricarboxylic acid cycle (GO:0006099)2.65996181
592-oxoglutarate metabolic process (GO:0006103)2.65160109
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64985410
61semaphorin-plexin signaling pathway (GO:0071526)2.64984180
62basement membrane organization (GO:0071711)2.64917345
63negative regulation of cell size (GO:0045792)2.64590622
64embryonic skeletal joint morphogenesis (GO:0060272)2.62973358
65myofibril assembly (GO:0030239)2.62085167
66alpha-linolenic acid metabolic process (GO:0036109)2.60505225
67nephron tubule morphogenesis (GO:0072078)2.59540778
68nephron epithelium morphogenesis (GO:0072088)2.59540778
69actin-mediated cell contraction (GO:0070252)2.58238800
70positive regulation of triglyceride metabolic process (GO:0090208)2.55935725
71protein localization to endosome (GO:0036010)2.54877700
72fatty acid beta-oxidation (GO:0006635)2.54418906
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53852802
74NADH metabolic process (GO:0006734)2.52700462
75collecting duct development (GO:0072044)2.52508377
76peptidyl-histidine modification (GO:0018202)2.50555672
77response to food (GO:0032094)2.50282270
78coronary vasculature morphogenesis (GO:0060977)2.48796125
79actomyosin structure organization (GO:0031032)2.47235059
80positive regulation of lipid catabolic process (GO:0050996)2.44593725
81mammary gland epithelial cell differentiation (GO:0060644)2.44308068
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.44278213
83positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43589525
84cell migration in hindbrain (GO:0021535)2.42644637
85carnitine transmembrane transport (GO:1902603)2.41067269
86regulation of hippo signaling (GO:0035330)2.40892573
87positive regulation of fatty acid metabolic process (GO:0045923)2.40664901
88cell migration involved in sprouting angiogenesis (GO:0002042)2.40341615
89regulation of triglyceride biosynthetic process (GO:0010866)2.39893688
90positive regulation of histone deacetylation (GO:0031065)2.39113349
91cardiac muscle contraction (GO:0060048)2.38994538
92preassembly of GPI anchor in ER membrane (GO:0016254)2.38986850
93positive regulation of glycogen metabolic process (GO:0070875)2.36950299
94glutathione biosynthetic process (GO:0006750)2.35662849
95cell communication by electrical coupling (GO:0010644)2.35247710
96proline metabolic process (GO:0006560)2.34949628
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.34783403
98white fat cell differentiation (GO:0050872)2.31994181
99pattern specification involved in kidney development (GO:0061004)2.31094290
100actin filament-based movement (GO:0030048)2.30777724
101negative regulation of catenin import into nucleus (GO:0035414)2.30466824
102negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30111761
103ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30046705
104adherens junction assembly (GO:0034333)2.30003440
105aspartate family amino acid catabolic process (GO:0009068)2.29714897
106hair cycle (GO:0042633)2.29589275
107molting cycle (GO:0042303)2.29589275
108vascular endothelial growth factor signaling pathway (GO:0038084)2.29364973
109cardiac muscle cell proliferation (GO:0060038)2.29102785
110carnitine transport (GO:0015879)2.28651281
111amino-acid betaine transport (GO:0015838)2.28651281
112regulation of cholesterol storage (GO:0010885)2.28150578
113response to misfolded protein (GO:0051788)2.28090680
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.28045405
115tricarboxylic acid metabolic process (GO:0072350)2.27283207
116stress fiber assembly (GO:0043149)2.26556114
117regulation of histone deacetylation (GO:0031063)2.26322291
118homocysteine metabolic process (GO:0050667)2.26281655
119respiratory system process (GO:0003016)2.25022859
120regulation of axon extension involved in axon guidance (GO:0048841)2.24447756
121fatty acid oxidation (GO:0019395)2.24379798
122positive regulation of cellular response to insulin stimulus (GO:1900078)2.23927680
123regulation of triglyceride catabolic process (GO:0010896)2.23321330
124sodium ion export (GO:0071436)2.23280572
125misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.22339328
126protein hydroxylation (GO:0018126)2.22143425
127regulation of tight junction assembly (GO:2000810)2.22007106
128lipid oxidation (GO:0034440)2.21364397
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.21035448
130cell-substrate adherens junction assembly (GO:0007045)2.20644881
131focal adhesion assembly (GO:0048041)2.20644881
132growth hormone secretion (GO:0030252)2.19957716
133establishment of tissue polarity (GO:0007164)2.17990169
134establishment of planar polarity (GO:0001736)2.17990169
135regulation of cardioblast differentiation (GO:0051890)2.17276967
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.16462444
137tRNA modification (GO:0006400)2.16068427
138cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.15839770
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.15547985
140dendritic spine morphogenesis (GO:0060997)2.15042239
141heart trabecula formation (GO:0060347)2.14806940
142sympathetic nervous system development (GO:0048485)2.14508440
143positive regulation of sodium ion transmembrane transport (GO:1902307)2.14419307
144cochlea morphogenesis (GO:0090103)2.14307129
145fatty acid catabolic process (GO:0009062)2.14298484
146positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.13870301
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.13799975
148urogenital system development (GO:0001655)2.13501875
149negative regulation of lipid transport (GO:0032369)2.13362434
150regulation of endothelial cell chemotaxis (GO:2001026)2.13205302
151blood vessel endothelial cell migration (GO:0043534)2.11838257
152positive regulation of glucose import (GO:0046326)2.11752621
153endodermal cell differentiation (GO:0035987)2.11683022
154acetyl-CoA metabolic process (GO:0006084)2.11671429
155negative regulation of heart growth (GO:0061117)2.11396820
156negative regulation of cardiac muscle tissue growth (GO:0055022)2.11396820
157COPI coating of Golgi vesicle (GO:0048205)2.11294619
158regulation of synapse maturation (GO:0090128)2.10532080
159response to pheromone (GO:0019236)2.10173261
160positive regulation of CREB transcription factor activity (GO:0032793)2.10125419
161convergent extension (GO:0060026)2.10067079
162nonribosomal peptide biosynthetic process (GO:0019184)2.06409797
163cranial nerve morphogenesis (GO:0021602)2.05374034
164creatine metabolic process (GO:0006600)2.04652911
165response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.03667613
166skeletal muscle adaptation (GO:0043501)2.02182225
167neuron fate specification (GO:0048665)2.01758396
168macroautophagy (GO:0016236)2.00324691
169regulation of hydrogen peroxide metabolic process (GO:0010310)1.99963981
170positive regulation of protein deacetylation (GO:0090312)1.99031832
171L-serine transport (GO:0015825)1.97994653
172regulation of establishment of planar polarity (GO:0090175)1.96874303
173mitochondrion transport along microtubule (GO:0047497)1.96822081
174establishment of mitochondrion localization, microtubule-mediated (GO:0034643)1.96822081
175outflow tract septum morphogenesis (GO:0003148)1.96612881
176protein insertion into membrane (GO:0051205)1.96475655
177heart valve morphogenesis (GO:0003179)1.95851281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.29526210
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32656464
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04160555
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.43247076
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79607408
6ZNF263_19887448_ChIP-Seq_K562_Human2.69761376
7CLOCK_20551151_ChIP-Seq_293T_Human2.61457145
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.54786708
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48100586
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.29671874
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.27968659
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.25995268
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18979320
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.13595868
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00945174
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98977612
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94558128
18* TET1_21451524_ChIP-Seq_MESCs_Mouse1.92470640
19LXR_22292898_ChIP-Seq_THP-1_Human1.87579562
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84625854
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.77155309
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.76368015
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74305137
24RACK7_27058665_Chip-Seq_MCF-7_Human1.73154908
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73145278
26KDM2B_26808549_Chip-Seq_K562_Human1.68227127
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66799677
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66513869
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63435206
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.62388042
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.62388042
32E2F1_20622854_ChIP-Seq_HELA_Human1.61976882
33MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.60048257
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.57826371
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55665721
36* SA1_27219007_Chip-Seq_ERYTHROID_Human1.54720825
37* FOXP1_21924763_ChIP-Seq_HESCs_Human1.50198803
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49781596
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49624856
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49082064
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.47664664
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46813640
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.46672607
44PHF8_20622854_ChIP-Seq_HELA_Human1.46273600
45BCOR_27268052_Chip-Seq_Bcells_Human1.46171815
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45908156
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45241926
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44846848
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44816484
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44676755
51* BCL6_27268052_Chip-Seq_Bcells_Human1.44539160
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43721346
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.43695183
54RARB_24833708_ChIP-Seq_LIVER_Mouse1.43396273
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42543698
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41558018
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40018407
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39676377
59* ATF3_27146783_Chip-Seq_COLON_Human1.38277844
60* KDM2B_26808549_Chip-Seq_DND41_Human1.37959302
61TP53_22127205_ChIP-Seq_IMR90_Human1.36285551
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36044960
63SA1_27219007_Chip-Seq_Bcells_Human1.36025127
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36018953
65XRN2_22483619_ChIP-Seq_HELA_Human1.35253622
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34149507
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33142765
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32698344
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32354926
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30392149
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.29445252
72CTCF_20526341_ChIP-Seq_ESCs_Human1.27728244
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26851131
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26688133
75ERA_21632823_ChIP-Seq_H3396_Human1.25982507
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.24374935
77DROSHA_22980978_ChIP-Seq_HELA_Human1.23629923
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22883707
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.22389925
80CREB1_26743006_Chip-Seq_LNCaP_Human1.22274269
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22096224
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21476086
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21070546
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21062820
85KDM5A_27292631_Chip-Seq_BREAST_Human1.21016634
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.20836236
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19996570
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19817696
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19685853
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.18837232
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18642112
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.18547345
93* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17864141
94* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17864141
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17009936
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15416002
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.14695706
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14200359
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14150594
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.13873919
101FOXA2_19822575_ChIP-Seq_HepG2_Human1.13443291
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12523933
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11283898
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10664584
105* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10613322
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10523702
107STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10344024
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10096901
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09622089
110* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08982538
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.08975282
112* TP63_22573176_ChIP-Seq_HFKS_Human1.08714073
113CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08569983
114VDR_21846776_ChIP-Seq_THP-1_Human1.07981344
115* TP53_20018659_ChIP-ChIP_R1E_Mouse1.07102710
116* CTCF_27219007_Chip-Seq_Bcells_Human1.06996842
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06929228
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06093979
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05952870
120* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05652012
121* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04511055
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03772130
123ETS1_20019798_ChIP-Seq_JURKAT_Human1.02524917
124OCT4_19829295_ChIP-Seq_ESCs_Human1.00887773
125RAC3_21632823_ChIP-Seq_H3396_Human1.00881147
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00192052
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99997380
128* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99175379
129* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98517459
130* EZH2_27294783_Chip-Seq_ESCs_Mouse0.98421564
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.98400461
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98237774
133* CTCF_21964334_Chip-Seq_Bcells_Human0.96433341
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96410679
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96410502
136* RNF2_27304074_Chip-Seq_ESCs_Mouse0.95894868
137SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95465086
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95295345
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95187954
140TCF7_22412390_ChIP-Seq_EML_Mouse0.95088054
141* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95076190
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95061650
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94794037
144P68_20966046_ChIP-Seq_HELA_Human0.94205615
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.93620998
146* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93519361
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93398125
148* KLF5_25053715_ChIP-Seq_YYC3_Human0.92299995
149SMC4_20622854_ChIP-Seq_HELA_Human0.92283689
150CJUN_26792858_Chip-Seq_BT549_Human0.92096735
151GATA6_25053715_ChIP-Seq_YYC3_Human0.90580888
152SOX2_20726797_ChIP-Seq_SW620_Human0.89333126
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89301464
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.89299108
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89064582
156FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88710538
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.88247754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.58652345
2MP0005275_abnormal_skin_tensile3.34823365
3MP0000751_myopathy3.15901684
4MP0002837_dystrophic_cardiac_calcinosis2.99462792
5MP0008438_abnormal_cutaneous_collagen2.98678702
6MP0010234_abnormal_vibrissa_follicle2.92242099
7MP0004084_abnormal_cardiac_muscle2.36824157
8MP0002249_abnormal_larynx_morphology2.35695839
9MP0003646_muscle_fatigue2.16813015
10MP0004130_abnormal_muscle_cell2.16336050
11MP0000566_synostosis2.13083590
12MP0004272_abnormal_basement_membrane2.12175997
13MP0005360_urolithiasis2.08356642
14MP0000749_muscle_degeneration2.07200454
15MP0004185_abnormal_adipocyte_glucose2.04863981
16MP0004145_abnormal_muscle_electrophysio2.03549488
17MP0005666_abnormal_adipose_tissue2.02126805
18MP0002796_impaired_skin_barrier2.00878920
19MP0000579_abnormal_nail_morphology1.97436302
20MP0004036_abnormal_muscle_relaxation1.96487511
21MP0001502_abnormal_circadian_rhythm1.90352226
22MP0004087_abnormal_muscle_fiber1.87853460
23MP0002139_abnormal_hepatobiliary_system1.85995856
24MP0004133_heterotaxia1.77592393
25MP0005670_abnormal_white_adipose1.77411408
26MP0005330_cardiomyopathy1.73239399
27MP0005623_abnormal_meninges_morphology1.73225038
28MP0000013_abnormal_adipose_tissue1.72629994
29MP0004147_increased_porphyrin_level1.72280535
30MP0005375_adipose_tissue_phenotype1.70566459
31MP0000678_abnormal_parathyroid_gland1.66607059
32MP0004858_abnormal_nervous_system1.66190882
33MP0005377_hearing/vestibular/ear_phenot1.64955830
34MP0003878_abnormal_ear_physiology1.64955830
35MP0000750_abnormal_muscle_regeneration1.63459588
36MP0003566_abnormal_cell_adhesion1.62460197
37MP0002269_muscular_atrophy1.59169876
38MP0005645_abnormal_hypothalamus_physiol1.58163104
39MP0002060_abnormal_skin_morphology1.57946447
40MP0003252_abnormal_bile_duct1.57918044
41MP0002234_abnormal_pharynx_morphology1.56361367
42MP0002877_abnormal_melanocyte_morpholog1.56241176
43MP0000747_muscle_weakness1.55692408
44MP0000003_abnormal_adipose_tissue1.51410689
45MP0006138_congestive_heart_failure1.49930598
46MP0001348_abnormal_lacrimal_gland1.46577945
47MP0000759_abnormal_skeletal_muscle1.45055471
48MP0009840_abnormal_foam_cell1.44457392
49MP0005620_abnormal_muscle_contractility1.43424574
50MP0009780_abnormal_chondrocyte_physiolo1.36741671
51MP0010329_abnormal_lipoprotein_level1.36334177
52MP0002106_abnormal_muscle_physiology1.35841972
53MP0005085_abnormal_gallbladder_physiolo1.34987236
54MP0004043_abnormal_pH_regulation1.33698532
55MP0004215_abnormal_myocardial_fiber1.33688469
56MP0003123_paternal_imprinting1.31611356
57MP0003283_abnormal_digestive_organ1.31532662
58MP0004885_abnormal_endolymph1.29991774
59MP0002909_abnormal_adrenal_gland1.29427175
60MP0002972_abnormal_cardiac_muscle1.29367688
61MP0008961_abnormal_basal_metabolism1.29138657
62MP0005365_abnormal_bile_salt1.28939125
63MP0004381_abnormal_hair_follicle1.27540751
64MP0001188_hyperpigmentation1.27382086
65MP0003045_fibrosis1.26542525
66MP0003279_aneurysm1.25641540
67MP0004233_abnormal_muscle_weight1.25351256
68MP0010630_abnormal_cardiac_muscle1.25007968
69MP0000733_abnormal_muscle_development1.24893443
70MP0003942_abnormal_urinary_system1.24270034
71MP0001958_emphysema1.22721918
72MP0002896_abnormal_bone_mineralization1.18996876
73MP0005083_abnormal_biliary_tract1.18090723
74MP0003191_abnormal_cellular_cholesterol1.17691523
75MP0002254_reproductive_system_inflammat1.15852449
76MP0005369_muscle_phenotype1.15646809
77MP0008775_abnormal_heart_ventricle1.14182869
78MP0001849_ear_inflammation1.12910141
79MP0005076_abnormal_cell_differentiation1.11955099
80MP0000049_abnormal_middle_ear1.11862757
81MP0001544_abnormal_cardiovascular_syste1.10208459
82MP0005385_cardiovascular_system_phenoty1.10208459
83MP0005501_abnormal_skin_physiology1.08713417
84MP0005646_abnormal_pituitary_gland1.07577407
85MP0001346_abnormal_lacrimal_gland1.06122135
86MP0010368_abnormal_lymphatic_system1.05732077
87MP0002971_abnormal_brown_adipose1.05643403
88MP0003300_gastrointestinal_ulcer1.01886060
89MP0009384_cardiac_valve_regurgitation1.00741299
90MP0010030_abnormal_orbit_morphology1.00534125
91MP0002108_abnormal_muscle_morphology0.98311853
92MP0000467_abnormal_esophagus_morphology0.96563311
93MP0002876_abnormal_thyroid_physiology0.95914058
94MP0000537_abnormal_urethra_morphology0.94734797
95MP0000538_abnormal_urinary_bladder0.94252764
96MP0010678_abnormal_skin_adnexa0.92442077
97MP0002118_abnormal_lipid_homeostasis0.92377607
98MP0003453_abnormal_keratinocyte_physiol0.91593421
99MP0000534_abnormal_ureter_morphology0.91466882
100MP0001661_extended_life_span0.89324494
101MP0002098_abnormal_vibrissa_morphology0.88778160
102MP0002938_white_spotting0.88472979
103MP0002116_abnormal_craniofacial_bone0.87564445
104MP0005503_abnormal_tendon_morphology0.86522872
105MP0004484_altered_response_of0.85692634
106MP0001666_abnormal_nutrient_absorption0.85096969
107MP0005187_abnormal_penis_morphology0.84870920
108MP0005257_abnormal_intraocular_pressure0.84843483
109MP0003137_abnormal_impulse_conducting0.84144612
110MP0003136_yellow_coat_color0.82977978
111MP0003755_abnormal_palate_morphology0.82782144
112MP0009250_abnormal_appendicular_skeleto0.82483973
113MP0000026_abnormal_inner_ear0.82349062
114MP0001270_distended_abdomen0.81760810
115MP0003693_abnormal_embryo_hatching0.80994308
116MP0005423_abnormal_somatic_nervous0.80788375
117MP0008995_early_reproductive_senescence0.79917442
118MP0008872_abnormal_physiological_respon0.79872386
119MP0005220_abnormal_exocrine_pancreas0.79770197
120MP0010771_integument_phenotype0.78578791
121MP0002932_abnormal_joint_morphology0.78543110
122MP0005167_abnormal_blood-brain_barrier0.78300722
123MP0001944_abnormal_pancreas_morphology0.78174361
124MP0000762_abnormal_tongue_morphology0.78033491
125MP0003195_calcinosis0.77534424
126MP0005332_abnormal_amino_acid0.77039214
127MP0001968_abnormal_touch/_nociception0.75763700
128MP0003091_abnormal_cell_migration0.75452496
129MP0000647_abnormal_sebaceous_gland0.75439171
130MP0003937_abnormal_limbs/digits/tail_de0.75181781
131MP0001299_abnormal_eye_distance/0.75113381
132MP0003879_abnormal_hair_cell0.74874582
133MP0003119_abnormal_digestive_system0.74779042
134MP0001243_abnormal_dermal_layer0.74731837
135MP0003329_amyloid_beta_deposits0.74593060
136MP0000383_abnormal_hair_follicle0.73478714
137MP0002163_abnormal_gland_morphology0.73140761
138MP0000681_abnormal_thyroid_gland0.72860588
139MP0009053_abnormal_anal_canal0.72556684
140MP0005023_abnormal_wound_healing0.72193899
141MP0002184_abnormal_innervation0.71862928
142MP0000377_abnormal_hair_follicle0.71089171
143MP0001216_abnormal_epidermal_layer0.71068089
144MP0005171_absent_coat_pigmentation0.70220646
145MP0000427_abnormal_hair_cycle0.69054327
146MP0006054_spinal_hemorrhage0.68394756
147MP0002970_abnormal_white_adipose0.67758173

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)4.41393064
2Type 1 muscle fiber predominance (HP:0003803)4.15929228
3Right ventricular cardiomyopathy (HP:0011663)4.11683437
4Exercise-induced myalgia (HP:0003738)3.67379303
5Hyporeflexia of lower limbs (HP:0002600)3.61431465
6Sudden death (HP:0001699)3.46814793
7Exercise-induced muscle cramps (HP:0003710)3.44887877
8Protrusio acetabuli (HP:0003179)3.42629091
9Muscle fiber splitting (HP:0003555)3.37847818
10Difficulty running (HP:0009046)3.35296894
11Premature rupture of membranes (HP:0001788)3.30751561
12Increased variability in muscle fiber diameter (HP:0003557)3.18504367
13Myoglobinuria (HP:0002913)3.15062099
14Cerebral aneurysm (HP:0004944)3.14906507
15Shallow orbits (HP:0000586)3.11746589
16Atrophic scars (HP:0001075)3.09590191
17Mildly elevated creatine phosphokinase (HP:0008180)3.08243674
18Ventricular tachycardia (HP:0004756)3.01992225
19Stridor (HP:0010307)2.97732645
20Testicular atrophy (HP:0000029)2.96671041
21Broad metatarsal (HP:0001783)2.92981379
22Abnormality of skeletal muscle fiber size (HP:0012084)2.91457155
23Ankle contracture (HP:0006466)2.89472394
24Concave nail (HP:0001598)2.86552933
25Difficulty climbing stairs (HP:0003551)2.77161418
26Fragile skin (HP:0001030)2.66500242
27Bundle branch block (HP:0011710)2.64854642
28Spinal rigidity (HP:0003306)2.59527896
29Abnormality of the aortic arch (HP:0012303)2.56122842
30Tubular atrophy (HP:0000092)2.54639609
31Myotonia (HP:0002486)2.52893234
32Asymmetric septal hypertrophy (HP:0001670)2.50842564
33Milia (HP:0001056)2.49265562
34Hyperthyroidism (HP:0000836)2.46583392
35Abnormality of the calf musculature (HP:0001430)2.46067253
36Ketoacidosis (HP:0001993)2.45290455
37Aplasia/Hypoplasia of the patella (HP:0006498)2.44498746
38Septate vagina (HP:0001153)2.44446534
39Round ear (HP:0100830)2.42693570
40Type II lissencephaly (HP:0007260)2.41694606
41Conjunctival hamartoma (HP:0100780)2.41366292
42Xanthomatosis (HP:0000991)2.41354156
43Upper limb amyotrophy (HP:0009129)2.40348120
44Distal upper limb amyotrophy (HP:0007149)2.40348120
45Calf muscle hypertrophy (HP:0008981)2.38063585
46Muscle fiber inclusion bodies (HP:0100299)2.36467363
47Infantile muscular hypotonia (HP:0008947)2.34294724
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34277576
49EMG: myopathic abnormalities (HP:0003458)2.33283761
50Deep venous thrombosis (HP:0002625)2.32608971
51Hypoglycemic coma (HP:0001325)2.30671797
52Patellar aplasia (HP:0006443)2.28634510
53Achilles tendon contracture (HP:0001771)2.27895688
54Abnormality of the Achilles tendon (HP:0005109)2.26290289
55Duplicated collecting system (HP:0000081)2.25182441
56Muscle hypertrophy of the lower extremities (HP:0008968)2.24285728
57Aneurysm (HP:0002617)2.23308548
58Bladder diverticulum (HP:0000015)2.23101487
59Scapular winging (HP:0003691)2.21754931
60Hamartoma of the eye (HP:0010568)2.21558473
61J-shaped sella turcica (HP:0002680)2.18460905
62Microretrognathia (HP:0000308)2.16364110
63Renal dysplasia (HP:0000110)2.15266409
64Lymphangioma (HP:0100764)2.15264354
65Ventricular fibrillation (HP:0001663)2.14427266
66Muscle stiffness (HP:0003552)2.11573049
67Hypoalphalipoproteinemia (HP:0003233)2.10471646
68Myopathic facies (HP:0002058)2.10209624
69Hypercortisolism (HP:0001578)2.09949539
70Hand muscle atrophy (HP:0009130)2.09345381
71Rhabdomyolysis (HP:0003201)2.08794426
72Long toe (HP:0010511)2.08703000
73Slender long bone (HP:0003100)2.08506547
74Abnormal atrioventricular conduction (HP:0005150)2.08338324
75Breast hypoplasia (HP:0003187)2.07985599
76Severe muscular hypotonia (HP:0006829)2.07666367
77Truncus arteriosus (HP:0001660)2.07416251
78Ulnar deviation of the wrist (HP:0003049)2.07242965
79Reticulocytosis (HP:0001923)2.05403060
80Aortic dissection (HP:0002647)2.01949784
81Mitral valve prolapse (HP:0001634)2.01436921
82Syncope (HP:0001279)1.99642975
83Ketosis (HP:0001946)1.99188551
84Lipoatrophy (HP:0100578)1.99085614
85Hyperkalemia (HP:0002153)1.96460396
86Enlarged penis (HP:0000040)1.96112449
87Ventricular arrhythmia (HP:0004308)1.96090460
88Turricephaly (HP:0000262)1.95747910
89Pendular nystagmus (HP:0012043)1.94810901
90Acanthosis nigricans (HP:0000956)1.94609652
91Heart block (HP:0012722)1.94408752
92Abnormality of the renal collecting system (HP:0004742)1.93896324
93Rib fusion (HP:0000902)1.91965063
94Hyperglycemia (HP:0003074)1.91853025
95Follicular hyperkeratosis (HP:0007502)1.88847901
96Easy fatigability (HP:0003388)1.88615665
97Obstructive sleep apnea (HP:0002870)1.88232872
98Mesangial abnormality (HP:0001966)1.87698819
99Molar tooth sign on MRI (HP:0002419)1.87296977
100Abnormality of midbrain morphology (HP:0002418)1.87296977
101Atrioventricular block (HP:0001678)1.86678492
102Cerebellar dysplasia (HP:0007033)1.85643387
103Hypoplastic ischia (HP:0003175)1.85488417
104Aplasia of the musculature (HP:0100854)1.83319555
105Subaortic stenosis (HP:0001682)1.83213664
106Abnormality of the left ventricular outflow tract (HP:0011103)1.83213664
107Back pain (HP:0003418)1.83012686
108Ureteral duplication (HP:0000073)1.82884219
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82773030
110Abnormality of alanine metabolism (HP:0010916)1.82773030
111Hyperalaninemia (HP:0003348)1.82773030
112Palpitations (HP:0001962)1.82605487
113Limb-girdle muscle atrophy (HP:0003797)1.82510319
114Peritonitis (HP:0002586)1.82478706
115Alopecia of scalp (HP:0002293)1.81149124
116Slender build (HP:0001533)1.80552046
117Cystic liver disease (HP:0006706)1.80306458
118Distal arthrogryposis (HP:0005684)1.79580108
119Prolonged QT interval (HP:0001657)1.78976280
120Nemaline bodies (HP:0003798)1.78827085
121Atrial fibrillation (HP:0005110)1.78653642
122Dysmetric saccades (HP:0000641)1.78514935
123Abnormal number of erythroid precursors (HP:0012131)1.78410135
124Bronchomalacia (HP:0002780)1.77132106
125Hyperacusis (HP:0010780)1.76387077
126Skin nodule (HP:0200036)1.76377622
127Hypotrichosis (HP:0001006)1.75040310
128Distal lower limb amyotrophy (HP:0008944)1.74659345
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72329342
130Squamous cell carcinoma (HP:0002860)1.70575529
131Rectal prolapse (HP:0002035)1.70492566
132Lip pit (HP:0100267)1.70284769
133Aortic aneurysm (HP:0004942)1.69764353
134Dilatation of the ascending aorta (HP:0005111)1.69744627
135Delayed CNS myelination (HP:0002188)1.68927254
136Advanced eruption of teeth (HP:0006288)1.68898585
137Large for gestational age (HP:0001520)1.68569459
138Nonimmune hydrops fetalis (HP:0001790)1.68038451
139Diaphragmatic weakness (HP:0009113)1.68031679
140Nephronophthisis (HP:0000090)1.67885581
141Woolly hair (HP:0002224)1.67605665
142Frequent falls (HP:0002359)1.67320169
143EMG: neuropathic changes (HP:0003445)1.66449703
144Onycholysis (HP:0001806)1.65380364
145Hyperglycinuria (HP:0003108)1.65060889
146Occipital encephalocele (HP:0002085)1.63320178
147Primary atrial arrhythmia (HP:0001692)1.62991645
148Bell-shaped thorax (HP:0001591)1.62617357
149Renovascular hypertension (HP:0100817)1.62153228
150Abnormality of nail color (HP:0100643)1.61864635
151Bicornuate uterus (HP:0000813)1.58761195
152Atelectasis (HP:0100750)1.58724742
153Calcaneovalgus deformity (HP:0001848)1.57126877
154Abnormality of the renal medulla (HP:0100957)1.56558339
155Elfin facies (HP:0004428)1.56487995
156Deformed tarsal bones (HP:0008119)1.54918640
157Increased corneal curvature (HP:0100692)1.54798061
158Keratoconus (HP:0000563)1.54798061
159Ulnar bowing (HP:0003031)1.54053585
160Down-sloping shoulders (HP:0200021)1.52626975
161Fatigable weakness (HP:0003473)1.51705312
162Abnormality of the neuromuscular junction (HP:0003398)1.51705312
163Amelogenesis imperfecta (HP:0000705)1.51563630
164Absent phalangeal crease (HP:0006109)1.51240449
165Bulbar palsy (HP:0001283)1.50906798
166Abnormal mitochondria in muscle tissue (HP:0008316)1.49940153
167Shawl scrotum (HP:0000049)1.49667300
168Polymicrogyria (HP:0002126)1.49634969
169Adducted thumb (HP:0001181)1.49149654
170Retinal dysplasia (HP:0007973)1.47964773
171Congenital malformation of the right heart (HP:0011723)1.47822764
172Double outlet right ventricle (HP:0001719)1.47822764
173Morphological abnormality of the middle ear (HP:0008609)1.47676130
174Broad face (HP:0000283)1.46952772
175Birth length less than 3rd percentile (HP:0003561)1.46155820
176Germ cell neoplasia (HP:0100728)1.45835133
177Hypoplasia of the capital femoral epiphysis (HP:0003090)1.45245143
178Cerebral palsy (HP:0100021)1.44673072
179Genetic anticipation (HP:0003743)1.44592376
180Chronic hepatic failure (HP:0100626)1.44497747
181Abnormality of the renal cortex (HP:0011035)1.43972539
182Flat cornea (HP:0007720)1.43773286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.20212659
2TTN3.85205193
3PKN23.22918294
4RIPK13.14220526
5ERN12.74204880
6SIK12.72602749
7PDGFRA2.25379166
8EEF2K2.22423423
9PTK62.12824141
10LATS12.02685319
11MUSK1.92886718
12EPHB21.88751592
13LMTK21.88385913
14PHKG11.81182842
15PHKG21.81182842
16DMPK1.66588129
17TLK11.61488882
18BCKDK1.48888121
19FER1.47357769
20PTK21.44788383
21SMG11.43963390
22DDR21.40205575
23MAP3K101.37750141
24OBSCN1.36307386
25STK391.33284739
26PRKD31.32203185
27NME21.30429640
28MST1R1.29468839
29MAP3K71.29202366
30EPHA21.28052351
31MAP2K61.24403623
32PDK41.23890565
33PDK31.23890565
34RPS6KB21.23707311
35BMX1.22846556
36LATS21.18841075
37EPHB11.18811231
38GRK11.16795430
39ICK1.16663144
40FGFR41.15260667
41MAPKAPK31.09938391
42RET1.07534974
43FRK1.04596029
44PRKCI1.04279505
45NEK11.04063226
46RPS6KA61.02977244
47IRAK31.01756807
48TYRO30.99550537
49KSR20.99538267
50MAP3K20.97397569
51MET0.96617146
52TAOK10.95815066
53PAK30.95474188
54PAK60.93695992
55RPS6KA50.92971884
56MAP3K30.91271937
57MAP2K10.91170009
58RPS6KL10.90006463
59RPS6KC10.90006463
60CAMK1D0.88549204
61PAK40.87923847
62AKT30.86762247
63LRRK20.85186744
64MTOR0.84776714
65PRKD10.83344204
66MAP2K20.82899010
67CHUK0.82761849
68TIE10.82595492
69NTRK10.82489717
70MARK10.81904407
71CDK80.81898881
72SIK20.81720337
73ILK0.81072728
74PRKCH0.79065861
75BRSK10.78727811
76MAP2K30.78281730
77PAK20.78116770
78PDGFRB0.77926804
79DYRK1B0.77926085
80MAPKAPK50.77606318
81MAP3K60.77490860
82STK380.77078749
83CAMK1G0.76994678
84MYLK0.75133120
85MAP4K20.75050549
86TNK20.72814350
87ROCK10.72671879
88PIK3CG0.71661046
89PINK10.70798877
90CAMKK10.68756933
91HIPK20.67891031
92NEK20.66995229
93CDC42BPA0.65733513
94LIMK10.65024200
95MARK20.63592741
96PRKAA10.63493699
97DAPK20.62567822
98TGFBR20.61162009
99CDK70.61115852
100CAMK10.61056051
101WNK40.60916874
102FGFR10.60640840
103MAP3K10.60099309
104PDK20.59816204
105ADRBK20.59540021
106PIM20.58447978
107PRKAA20.58003756
108RPS6KA20.57743284
109DYRK20.57007162
110NME10.56846560
111EPHA30.56709740
112WNK10.55616026
113FGFR20.55584594
114INSRR0.55558042
115STK38L0.55477054
116RPS6KA10.54845874
117BRAF0.54363297
118TESK10.54117652
119ZAK0.53873499
120PIK3CA0.53398550
121MAPK80.52930064
122ERBB20.51575671
123AKT20.51502960
124MAP2K40.50954480
125NTRK30.49390696
126PDPK10.49105269
127MAPK110.48150004
128MAPK120.46979941
129MAPK150.46118705
130SCYL20.45899312
131ERBB40.44989350
132PRKD20.44958586
133PKN10.44281554
134CAMK2G0.44102749
135CDK60.43711538
136MAPK130.43057450
137ALK0.42336478
138STK240.42323163
139TRPM70.42170770
140CHEK20.42111445
141FLT30.40639614
142FGFR30.40407643
143PTK2B0.40173121
144SGK30.39784136
145GSK3A0.39736079
146DAPK30.39604657

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.46948878
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82932921
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44899456
4Fatty acid degradation_Homo sapiens_hsa000712.36606983
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35377278
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08867100
7PPAR signaling pathway_Homo sapiens_hsa033202.04461759
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96127240
9Fatty acid metabolism_Homo sapiens_hsa012121.92702112
10Nitrogen metabolism_Homo sapiens_hsa009101.91647393
11Propanoate metabolism_Homo sapiens_hsa006401.88519645
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85401231
13Arginine biosynthesis_Homo sapiens_hsa002201.81186560
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76540408
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75220324
16One carbon pool by folate_Homo sapiens_hsa006701.68031787
17Dilated cardiomyopathy_Homo sapiens_hsa054141.67352681
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64018724
19Fat digestion and absorption_Homo sapiens_hsa049751.56344352
20ECM-receptor interaction_Homo sapiens_hsa045121.54072675
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52569992
22Bile secretion_Homo sapiens_hsa049761.47750678
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47095621
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46809488
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46778761
26Vitamin B6 metabolism_Homo sapiens_hsa007501.45737605
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43952184
28Carbon metabolism_Homo sapiens_hsa012001.41018193
29Tryptophan metabolism_Homo sapiens_hsa003801.36654744
30Butanoate metabolism_Homo sapiens_hsa006501.33737138
31Insulin resistance_Homo sapiens_hsa049311.32746143
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29250031
33Focal adhesion_Homo sapiens_hsa045101.27034641
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25654468
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.24953202
36Linoleic acid metabolism_Homo sapiens_hsa005911.23545808
37Oxidative phosphorylation_Homo sapiens_hsa001901.22615387
38Starch and sucrose metabolism_Homo sapiens_hsa005001.20386011
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19395954
40Fatty acid biosynthesis_Homo sapiens_hsa000611.19388860
41Pyruvate metabolism_Homo sapiens_hsa006201.18184216
42Protein digestion and absorption_Homo sapiens_hsa049741.14387269
43Amoebiasis_Homo sapiens_hsa051461.13436299
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13052708
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12974936
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.10110608
47Basal transcription factors_Homo sapiens_hsa030221.07329759
48Lysine degradation_Homo sapiens_hsa003101.07284755
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03699020
50Ovarian steroidogenesis_Homo sapiens_hsa049131.03472556
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02541855
52Insulin signaling pathway_Homo sapiens_hsa049101.00311920
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.98957601
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98627882
55Proteoglycans in cancer_Homo sapiens_hsa052050.97233550
56Glucagon signaling pathway_Homo sapiens_hsa049220.96884422
57Axon guidance_Homo sapiens_hsa043600.96767373
58AMPK signaling pathway_Homo sapiens_hsa041520.96245048
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94400239
60Bladder cancer_Homo sapiens_hsa052190.91106965
61Type II diabetes mellitus_Homo sapiens_hsa049300.90570049
62Phototransduction_Homo sapiens_hsa047440.89683243
63Biosynthesis of amino acids_Homo sapiens_hsa012300.89298036
64RNA polymerase_Homo sapiens_hsa030200.89070785
65Fanconi anemia pathway_Homo sapiens_hsa034600.88044272
66Parkinsons disease_Homo sapiens_hsa050120.86972429
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85334217
68Adherens junction_Homo sapiens_hsa045200.82651831
69beta-Alanine metabolism_Homo sapiens_hsa004100.82343929
70Basal cell carcinoma_Homo sapiens_hsa052170.81800550
71Homologous recombination_Homo sapiens_hsa034400.81404539
72Tight junction_Homo sapiens_hsa045300.81384615
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.80938915
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78750152
75Complement and coagulation cascades_Homo sapiens_hsa046100.77972705
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77434703
77Cardiac muscle contraction_Homo sapiens_hsa042600.76736106
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75797155
79Phenylalanine metabolism_Homo sapiens_hsa003600.72176726
80Circadian rhythm_Homo sapiens_hsa047100.71828374
81Caffeine metabolism_Homo sapiens_hsa002320.71701110
82mTOR signaling pathway_Homo sapiens_hsa041500.70923944
83Huntingtons disease_Homo sapiens_hsa050160.70723518
84Steroid biosynthesis_Homo sapiens_hsa001000.70173515
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70077393
86Estrogen signaling pathway_Homo sapiens_hsa049150.69962765
87Ribosome_Homo sapiens_hsa030100.69810820
88Glycerolipid metabolism_Homo sapiens_hsa005610.69673199
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.69598654
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69550153
91Gastric acid secretion_Homo sapiens_hsa049710.69394603
92Hedgehog signaling pathway_Homo sapiens_hsa043400.69363318
93Galactose metabolism_Homo sapiens_hsa000520.68894591
94Base excision repair_Homo sapiens_hsa034100.68480348
95Ether lipid metabolism_Homo sapiens_hsa005650.68278052
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67506642
97Metabolic pathways_Homo sapiens_hsa011000.67455767
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67040609
99Sulfur metabolism_Homo sapiens_hsa009200.66583459
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66208530
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65619887
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.63506050
103Insulin secretion_Homo sapiens_hsa049110.61346649
104Alzheimers disease_Homo sapiens_hsa050100.61248668
105Histidine metabolism_Homo sapiens_hsa003400.61112560
106Small cell lung cancer_Homo sapiens_hsa052220.60546759
107Thyroid hormone synthesis_Homo sapiens_hsa049180.59857489
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59266192
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58654343
110Peroxisome_Homo sapiens_hsa041460.58641975
111Hippo signaling pathway_Homo sapiens_hsa043900.58262378
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.57795612
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57166351
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56300695
115Dorso-ventral axis formation_Homo sapiens_hsa043200.56067985
116GnRH signaling pathway_Homo sapiens_hsa049120.55803719
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55505316
118Glioma_Homo sapiens_hsa052140.55267122
119ABC transporters_Homo sapiens_hsa020100.54938266
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54566341
121Selenocompound metabolism_Homo sapiens_hsa004500.54375401
122VEGF signaling pathway_Homo sapiens_hsa043700.53563901
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53270586
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.53240547
125Fatty acid elongation_Homo sapiens_hsa000620.52433759
126Pyrimidine metabolism_Homo sapiens_hsa002400.51787620
127Melanogenesis_Homo sapiens_hsa049160.51325424
128Fructose and mannose metabolism_Homo sapiens_hsa000510.50607016
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50446509
130Pancreatic secretion_Homo sapiens_hsa049720.49266972
131Renin secretion_Homo sapiens_hsa049240.49027941
132Endometrial cancer_Homo sapiens_hsa052130.47500013
133Arginine and proline metabolism_Homo sapiens_hsa003300.47417983
134Chronic myeloid leukemia_Homo sapiens_hsa052200.47341664
135Oxytocin signaling pathway_Homo sapiens_hsa049210.47148661
136Tyrosine metabolism_Homo sapiens_hsa003500.46277258
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44445682
138Viral myocarditis_Homo sapiens_hsa054160.42666308
139Notch signaling pathway_Homo sapiens_hsa043300.41875055
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40701651
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.40541989

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