PLEKHM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.25465706
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.13667622
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.13667622
4modulation by symbiont of host immune response (GO:0052553)5.13667622
5positive regulation by symbiont of host defense response (GO:0052509)5.13667622
6modulation by symbiont of host defense response (GO:0052031)5.13667622
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.13667622
8positive regulation of gamma-delta T cell activation (GO:0046645)4.39921335
9response to peptidoglycan (GO:0032494)4.09880676
10macrophage activation involved in immune response (GO:0002281)4.07841221
11regulation of B cell receptor signaling pathway (GO:0050855)4.00223974
12detection of other organism (GO:0098543)3.95948642
13detection of bacterium (GO:0016045)3.78310764
14mannose metabolic process (GO:0006013)3.74789033
15regulation of gamma-delta T cell differentiation (GO:0045586)3.72438632
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60926346
17negative regulation of cell killing (GO:0031342)3.60926346
18regulation of gamma-delta T cell activation (GO:0046643)3.58846881
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58059882
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58059882
21positive regulation of histone deacetylation (GO:0031065)3.53481981
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51315777
23positive regulation of p38MAPK cascade (GO:1900745)3.48941656
24antigen processing and presentation of endogenous antigen (GO:0019883)3.48435073
25detection of external biotic stimulus (GO:0098581)3.46498392
26negative regulation of granulocyte differentiation (GO:0030853)3.45820504
27regulation of mast cell degranulation (GO:0043304)3.43778587
28positive regulation of interferon-alpha production (GO:0032727)3.43032976
29B cell receptor signaling pathway (GO:0050853)3.37830769
30regulation of interferon-alpha production (GO:0032647)3.31352976
31positive regulation of B cell differentiation (GO:0045579)3.31329894
32regulation of integrin activation (GO:0033623)3.28552388
33pinocytosis (GO:0006907)3.25112616
34response to host immune response (GO:0052572)3.23993859
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23993859
36regulation of mast cell activation involved in immune response (GO:0033006)3.21690945
37positive thymic T cell selection (GO:0045059)3.21488286
38immunoglobulin mediated immune response (GO:0016064)3.19033924
39apoptotic cell clearance (GO:0043277)3.18641636
40regulation of cholesterol storage (GO:0010885)3.15658505
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.10917077
42regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08896354
43low-density lipoprotein particle clearance (GO:0034383)3.08007848
44negative regulation of erythrocyte differentiation (GO:0045647)3.07618665
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06788104
46response to host (GO:0075136)3.06788104
47response to host defenses (GO:0052200)3.06788104
48detection of biotic stimulus (GO:0009595)3.04592127
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02747219
50negative regulation of leukocyte mediated immunity (GO:0002704)2.99780623
51L-alpha-amino acid transmembrane transport (GO:1902475)2.95538890
52regulation of mast cell activation (GO:0033003)2.93587075
53I-kappaB phosphorylation (GO:0007252)2.93393064
54negative regulation of interleukin-12 production (GO:0032695)2.92989651
55response to laminar fluid shear stress (GO:0034616)2.92530202
56microglial cell activation (GO:0001774)2.92464826
57lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89830899
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88880528
59negative regulation of T cell mediated immunity (GO:0002710)2.86173229
60NLS-bearing protein import into nucleus (GO:0006607)2.80982249
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79773053
62natural killer cell mediated cytotoxicity (GO:0042267)2.78252705
63natural killer cell mediated immunity (GO:0002228)2.78252705
64response to type I interferon (GO:0034340)2.78022649
65respiratory burst (GO:0045730)2.76145621
66regulation of interleukin-12 biosynthetic process (GO:0045075)2.75441062
67cellular response to type I interferon (GO:0071357)2.74097127
68type I interferon signaling pathway (GO:0060337)2.74097127
69pre-miRNA processing (GO:0031054)2.73761343
70regulation of B cell differentiation (GO:0045577)2.72972785
71positive regulation of mast cell activation (GO:0033005)2.72671804
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68893265
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68825095
74defense response to protozoan (GO:0042832)2.68648340
75regulation of T-helper 2 cell differentiation (GO:0045628)2.68623050
76positive regulation of antigen processing and presentation (GO:0002579)2.67867869
77negative regulation of toll-like receptor signaling pathway (GO:0034122)2.67612853
78regulation of T cell tolerance induction (GO:0002664)2.67120706
79regulation of regulated secretory pathway (GO:1903305)2.65964361
80regulation of p38MAPK cascade (GO:1900744)2.64526929
81negative regulation of cytokine production involved in immune response (GO:0002719)2.64214833
82positive regulation of interferon-beta production (GO:0032728)2.63942926
83neutrophil activation involved in immune response (GO:0002283)2.63082353
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60557391
85response to interleukin-15 (GO:0070672)2.60447824
86positive regulation of protein deacetylation (GO:0090312)2.59955900
87negative regulation of stress fiber assembly (GO:0051497)2.59735196
88regulation of tolerance induction (GO:0002643)2.59512940
89response to protozoan (GO:0001562)2.59453774
90cytoplasmic mRNA processing body assembly (GO:0033962)2.58852726
91detection of molecule of bacterial origin (GO:0032490)2.58310304
92positive regulation of cellular amide metabolic process (GO:0034250)2.57687322
93negative regulation of interleukin-6 production (GO:0032715)2.56185117
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54954603
95negative regulation of type 2 immune response (GO:0002829)2.54324760
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.54087021
97negative regulation of phagocytosis (GO:0050765)2.53354047
98negative regulation of innate immune response (GO:0045824)2.51622037
99macrophage activation (GO:0042116)2.51283066
100interferon-gamma-mediated signaling pathway (GO:0060333)2.51166942
101regulation of T cell mediated cytotoxicity (GO:0001914)2.49659089
102positive regulation of mast cell activation involved in immune response (GO:0033008)2.49381982
103positive regulation of mast cell degranulation (GO:0043306)2.49381982
104antigen processing and presentation via MHC class Ib (GO:0002475)2.49250407
105B cell homeostasis (GO:0001782)2.47532937
106leukocyte migration involved in inflammatory response (GO:0002523)2.47264790
107negative regulation of B cell proliferation (GO:0030889)2.47044229
108lipoprotein transport (GO:0042953)2.45566740
109B cell mediated immunity (GO:0019724)2.44438097
110response to UV-C (GO:0010225)2.43564542
111negative thymic T cell selection (GO:0045060)2.43299888
112negative regulation of interleukin-8 production (GO:0032717)2.42220256
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.41725602
114cellular response to interleukin-15 (GO:0071350)2.41541564
115neutrophil activation (GO:0042119)2.41329399
116regulation of antigen processing and presentation (GO:0002577)2.40747201
117regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40532132
118myeloid leukocyte activation (GO:0002274)2.40215363
119negative regulation of T-helper cell differentiation (GO:0045623)2.40178055
120negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40178055
121leukocyte degranulation (GO:0043299)2.39473147
122positive regulation of T cell mediated cytotoxicity (GO:0001916)2.39385985
123myeloid cell activation involved in immune response (GO:0002275)2.39222709
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38560751
125T-helper 1 type immune response (GO:0042088)2.38469932
126production of molecular mediator involved in inflammatory response (GO:0002532)2.38447265
127positive regulation of gene expression, epigenetic (GO:0045815)2.38344756
128NIK/NF-kappaB signaling (GO:0038061)2.38278499
129negative regulation of histone methylation (GO:0031061)2.37240317
130granulocyte activation (GO:0036230)2.37062513
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35484505
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.35315489
133tolerance induction (GO:0002507)2.34841766
134cellular extravasation (GO:0045123)2.34359900
135positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.33586039
136negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.32819378
137neutrophil mediated immunity (GO:0002446)2.32002017
138response to muramyl dipeptide (GO:0032495)2.30328451
139positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.30219760
140germinal center formation (GO:0002467)2.28474276
141embryonic placenta development (GO:0001892)2.28194743
142positive regulation of cell adhesion mediated by integrin (GO:0033630)2.26937971
143regulation of granulocyte differentiation (GO:0030852)2.26531855
144regulation of interferon-beta production (GO:0032648)2.25864286
145response to fluid shear stress (GO:0034405)2.25146664
146regulation of phagocytosis (GO:0050764)2.23519758
147leukocyte aggregation (GO:0070486)2.23460655
148modulation by symbiont of host cellular process (GO:0044068)2.23377611
149thymic T cell selection (GO:0045061)2.22472201
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.22017641
151regulation of leukocyte degranulation (GO:0043300)2.21676049
152regulation of SMAD protein import into nucleus (GO:0060390)2.21352726
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20813299
154regulation of superoxide anion generation (GO:0032928)2.20518876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.59596973
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.45738072
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40627698
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.33563936
5MYC_22102868_ChIP-Seq_BL_Human3.16272632
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.08211583
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.07364670
8VDR_21846776_ChIP-Seq_THP-1_Human2.71604474
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70888949
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.62399960
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62006735
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57446121
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53594416
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31230554
15TCF7_22412390_ChIP-Seq_EML_Mouse2.25693505
16* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14322737
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13326925
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05217953
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01852800
20SCL_19346495_ChIP-Seq_HPC-7_Human1.97995895
21MAF_26560356_Chip-Seq_TH1_Human1.96892441
22SPI1_23127762_ChIP-Seq_K562_Human1.94375613
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94346040
24KDM2B_26808549_Chip-Seq_DND41_Human1.91791623
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.90887935
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90626329
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85832298
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83114550
29VDR_24763502_ChIP-Seq_THP-1_Human1.77399141
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77198118
31UTX_26944678_Chip-Seq_JUKART_Human1.76858851
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67905813
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66429559
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66390876
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.65323432
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64976874
37MYB_26560356_Chip-Seq_TH1_Human1.63691331
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62660397
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.59654142
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.54215014
41MYB_26560356_Chip-Seq_TH2_Human1.52521951
42SPI1_23547873_ChIP-Seq_NB4_Human1.52110296
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51678968
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49424922
45RUNX_20019798_ChIP-Seq_JUKART_Human1.46789195
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45419489
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44045904
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41155989
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40814777
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40238725
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38923570
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37830868
53TFEB_21752829_ChIP-Seq_HELA_Human1.37056039
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35662370
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33586814
56NCOR1_26117541_ChIP-Seq_K562_Human1.33033385
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30885324
58LXR_22292898_ChIP-Seq_THP-1_Human1.29718301
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29106252
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28449555
61MAF_26560356_Chip-Seq_TH2_Human1.26256783
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25880159
63PU_27001747_Chip-Seq_BMDM_Mouse1.25402112
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23975664
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.22281293
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21676383
67KDM2B_26808549_Chip-Seq_K562_Human1.21222505
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21102918
69RACK7_27058665_Chip-Seq_MCF-7_Human1.20737342
70CLOCK_20551151_ChIP-Seq_293T_Human1.18285660
71DROSHA_22980978_ChIP-Seq_HELA_Human1.17796622
72* FOXO3_23340844_ChIP-Seq_DLD1_Human1.17521644
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17238726
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16205789
75GATA1_19941826_ChIP-Seq_K562_Human1.15439551
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14257894
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14164003
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12948039
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.12879637
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.12878246
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12778396
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11092384
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11017467
84GATA2_19941826_ChIP-Seq_K562_Human1.10996618
85* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10893725
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10665411
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10328370
88* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09593715
89BCL6_27268052_Chip-Seq_Bcells_Human1.09282658
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.09011747
91BCOR_27268052_Chip-Seq_Bcells_Human1.08683824
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.08579674
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07429835
94* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05765258
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05277802
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04871227
97CIITA_25753668_ChIP-Seq_RAJI_Human1.04858120
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.04718228
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.04628467
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04605821
101* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03823566
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02922114
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02103042
104GATA6_25053715_ChIP-Seq_YYC3_Human1.01190060
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00520085
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00023075
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99604885
108GATA1_22025678_ChIP-Seq_K562_Human0.98735740
109* ATF3_27146783_Chip-Seq_COLON_Human0.98714415
110GATA3_27048872_Chip-Seq_THYMUS_Human0.97434602
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96244288
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95999745
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.95499015
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95489643
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94460881
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93799305
117* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93776346
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93748896
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93697683
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92942748
121VDR_24787735_ChIP-Seq_THP-1_Human0.92517907
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91734218
123* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91592120
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91587803
125SMC4_20622854_ChIP-Seq_HELA_Human0.91305548
126GATA3_26560356_Chip-Seq_TH2_Human0.90584243
127P68_20966046_ChIP-Seq_HELA_Human0.89492317
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88521941
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.86049717
130TP63_22573176_ChIP-Seq_HFKS_Human0.85942124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.86406791
2MP0000569_abnormal_digit_pigmentation3.66577220
3MP0005058_abnormal_lysosome_morphology3.39887526
4MP0003303_peritoneal_inflammation3.13135334
5MP0003172_abnormal_lysosome_physiology2.57724786
6MP0001835_abnormal_antigen_presentation2.47888810
7MP0003300_gastrointestinal_ulcer2.47274872
8MP0009278_abnormal_bone_marrow2.46574707
9MP0003705_abnormal_hypodermis_morpholog2.44344291
10MP0003436_decreased_susceptibility_to2.29436076
11MP0005076_abnormal_cell_differentiation2.24161261
12MP0002148_abnormal_hypersensitivity_rea2.23977917
13MP0001800_abnormal_humoral_immune2.19618573
14MP0001790_abnormal_immune_system2.16218733
15MP0005387_immune_system_phenotype2.16218733
16MP0009840_abnormal_foam_cell2.12198547
17MP0004510_myositis2.09629859
18MP0003566_abnormal_cell_adhesion2.08632369
19MP0010307_abnormal_tumor_latency2.07374348
20MP0003191_abnormal_cellular_cholesterol1.95609548
21MP0002452_abnormal_antigen_presenting1.93970226
22MP0010352_gastrointestinal_tract_polyps1.90933623
23MP0002419_abnormal_innate_immunity1.82018906
24MP0000685_abnormal_immune_system1.78070465
25MP0004185_abnormal_adipocyte_glucose1.66328178
26MP0005000_abnormal_immune_tolerance1.65597764
27MP0006082_CNS_inflammation1.65254551
28MP0002723_abnormal_immune_serum1.64274849
29MP0002396_abnormal_hematopoietic_system1.64135158
30MP0009764_decreased_sensitivity_to1.62862601
31MP0005464_abnormal_platelet_physiology1.61861445
32MP0004947_skin_inflammation1.61795123
33MP0005257_abnormal_intraocular_pressure1.61325450
34MP0002420_abnormal_adaptive_immunity1.58961876
35MP0002166_altered_tumor_susceptibility1.58826618
36MP0005397_hematopoietic_system_phenotyp1.58540648
37MP0001545_abnormal_hematopoietic_system1.58540648
38MP0001819_abnormal_immune_cell1.58313938
39MP0002398_abnormal_bone_marrow1.53233192
40MP0000689_abnormal_spleen_morphology1.52328817
41MP0004808_abnormal_hematopoietic_stem1.51997454
42MP0005025_abnormal_response_to1.50925273
43MP0008260_abnormal_autophagy1.42362117
44MP0003075_altered_response_to1.42297170
45MP0008961_abnormal_basal_metabolism1.41516943
46MP0003448_altered_tumor_morphology1.40287819
47MP0000716_abnormal_immune_system1.39939633
48MP0002405_respiratory_system_inflammati1.38315989
49MP0002722_abnormal_immune_system1.37013616
50MP0004381_abnormal_hair_follicle1.36370282
51MP0005670_abnormal_white_adipose1.35714352
52MP0005174_abnormal_tail_pigmentation1.34097760
53MP0005451_abnormal_body_composition1.29946059
54MP0005671_abnormal_response_to1.29363819
55MP0004883_abnormal_blood_vessel1.27327815
56MP0005164_abnormal_response_to1.27012227
57MP0002429_abnormal_blood_cell1.22443580
58MP0001533_abnormal_skeleton_physiology1.22230559
59MP0000371_diluted_coat_color1.19585662
60MP0001845_abnormal_inflammatory_respons1.18078026
61MP0005023_abnormal_wound_healing1.17275632
62MP0003045_fibrosis1.15704215
63MP0002138_abnormal_hepatobiliary_system1.13745750
64MP0001849_ear_inflammation1.13364092
65MP0000465_gastrointestinal_hemorrhage1.13142231
66MP0003866_abnormal_defecation1.12829399
67MP0009333_abnormal_splenocyte_physiolog1.12794595
68MP0005390_skeleton_phenotype1.10605335
69MP0003183_abnormal_peptide_metabolism1.10370774
70MP0000858_altered_metastatic_potential1.09415245
71MP0003279_aneurysm1.09218066
72MP0010155_abnormal_intestine_physiology1.08710638
73MP0004130_abnormal_muscle_cell1.08426925
74MP0001958_emphysema1.07694097
75MP0001873_stomach_inflammation1.07373639
76MP0008004_abnormal_stomach_pH1.07328461
77MP0003690_abnormal_glial_cell1.06157370
78MP0003828_pulmonary_edema1.05995993
79MP0003091_abnormal_cell_migration1.05930000
80MP0000703_abnormal_thymus_morphology1.05406882
81MP0000609_abnormal_liver_physiology1.04647816
82MP0002006_tumorigenesis1.04355729
83MP0003111_abnormal_nucleus_morphology1.04068952
84MP0005167_abnormal_blood-brain_barrier1.02806088
85MP0009785_altered_susceptibility_to1.02308384
86MP0005310_abnormal_salivary_gland1.01894422
87MP0005666_abnormal_adipose_tissue1.01233293
88MP0005166_decreased_susceptibility_to0.99898385
89MP0000733_abnormal_muscle_development0.99741290
90MP0002332_abnormal_exercise_endurance0.95766839
91MP0000490_abnormal_crypts_of0.95285742
92MP0000015_abnormal_ear_pigmentation0.92744399
93MP0002998_abnormal_bone_remodeling0.92288667
94MP0003453_abnormal_keratinocyte_physiol0.91849302
95MP0010329_abnormal_lipoprotein_level0.91122532
96MP0000249_abnormal_blood_vessel0.89429220
97MP0003329_amyloid_beta_deposits0.89317449
98MP0001663_abnormal_digestive_system0.88791801
99MP0005375_adipose_tissue_phenotype0.87892199
100MP0009115_abnormal_fat_cell0.87608355
101MP0008469_abnormal_protein_level0.87555091
102MP0003656_abnormal_erythrocyte_physiolo0.85805907
103MP0003763_abnormal_thymus_physiology0.84302503
104MP0005621_abnormal_cell_physiology0.81127733
105MP0001915_intracranial_hemorrhage0.80727401
106MP0000598_abnormal_liver_morphology0.80207449
107MP0002933_joint_inflammation0.78472881
108MP0001851_eye_inflammation0.77857889
109MP0002019_abnormal_tumor_incidence0.77691100
110MP0001853_heart_inflammation0.76784169
111MP0002086_abnormal_extraembryonic_tissu0.76141536
112MP0003795_abnormal_bone_structure0.76127124
113MP0003077_abnormal_cell_cycle0.75201593
114MP0003984_embryonic_growth_retardation0.74906515
115MP0002088_abnormal_embryonic_growth/wei0.74883005
116MP0002136_abnormal_kidney_physiology0.74632217
117MP0002277_abnormal_respiratory_mucosa0.73298822
118MP0000604_amyloidosis0.72596122
119MP0000343_altered_response_to0.72022914
120MP0000003_abnormal_adipose_tissue0.71855575
121MP0000767_abnormal_smooth_muscle0.71853115
122MP0010630_abnormal_cardiac_muscle0.70903547
123MP0005360_urolithiasis0.70503688
124MP0008438_abnormal_cutaneous_collagen0.69991819
125MP0001986_abnormal_taste_sensitivity0.68834265
126MP0006054_spinal_hemorrhage0.64951005
127MP0008874_decreased_physiological_sensi0.64949359
128MP0002254_reproductive_system_inflammat0.64828505
129MP0009763_increased_sensitivity_to0.64083180
130MP0005409_darkened_coat_color0.63920232
131MP0002132_abnormal_respiratory_system0.63663187
132MP0005595_abnormal_vascular_smooth0.61095600
133MP0000470_abnormal_stomach_morphology0.60439468
134MP0000920_abnormal_myelination0.59566894

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)4.26917009
2Recurrent abscess formation (HP:0002722)3.91416156
3Retrobulbar optic neuritis (HP:0100654)3.81180114
4Optic neuritis (HP:0100653)3.81180114
5Stomatitis (HP:0010280)3.64672450
6Recurrent bacterial skin infections (HP:0005406)3.59518748
7Autoimmune thrombocytopenia (HP:0001973)3.52213858
8Eczematoid dermatitis (HP:0000976)3.37908901
9Increased IgE level (HP:0003212)3.33884682
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.27116982
11Cerebral aneurysm (HP:0004944)3.24168137
12Vacuolated lymphocytes (HP:0001922)3.15806978
13Abnormality of the fingertips (HP:0001211)3.14982001
14Dysostosis multiplex (HP:0000943)3.13861140
15Cellulitis (HP:0100658)3.06522573
16Gastrointestinal infarctions (HP:0005244)2.93788991
17Keratoconjunctivitis sicca (HP:0001097)2.91369345
18Recurrent gram-negative bacterial infections (HP:0005420)2.88526537
19Abnormality of liposaccharide metabolism (HP:0010968)2.87881407
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.87881407
21Abnormality of glycolipid metabolism (HP:0010969)2.87881407
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82861357
23Abnormality of polysaccharide metabolism (HP:0011012)2.82861357
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82861357
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.82114216
26Pustule (HP:0200039)2.79543902
27Recurrent fungal infections (HP:0002841)2.78970795
28Abnormality of macrophages (HP:0004311)2.75688143
29Keratoconjunctivitis (HP:0001096)2.74611387
30Mucopolysacchariduria (HP:0008155)2.72748511
31Urinary glycosaminoglycan excretion (HP:0003541)2.72748511
32Recurrent viral infections (HP:0004429)2.70907937
33Myocardial infarction (HP:0001658)2.70386948
34Colitis (HP:0002583)2.67772439
35Periodontitis (HP:0000704)2.64018779
36Systemic lupus erythematosus (HP:0002725)2.60473763
37Gingivitis (HP:0000230)2.58422970
38Hemoptysis (HP:0002105)2.52854829
39Pulmonary infiltrates (HP:0002113)2.47516618
40Global brain atrophy (HP:0002283)2.42348881
41Interstitial pulmonary disease (HP:0006530)2.39776643
42Encephalitis (HP:0002383)2.38904291
43Inflammation of the large intestine (HP:0002037)2.35374328
44Loss of speech (HP:0002371)2.35370868
45Disinhibition (HP:0000734)2.32772572
46Osteomyelitis (HP:0002754)2.30134539
47Hematochezia (HP:0002573)2.29319986
48Axonal loss (HP:0003447)2.28983811
49Amyloidosis (HP:0011034)2.28576304
50Gastrointestinal inflammation (HP:0004386)2.28425546
51Ulnar bowing (HP:0003031)2.28416157
52Peritonitis (HP:0002586)2.26911108
53Epistaxis (HP:0000421)2.25050522
54T lymphocytopenia (HP:0005403)2.21401466
55Chronic otitis media (HP:0000389)2.20992780
56Hypochromic anemia (HP:0001931)2.20764681
57Recurrent skin infections (HP:0001581)2.20552572
58Chest pain (HP:0100749)2.18846802
59Asymmetric septal hypertrophy (HP:0001670)2.17599325
60Upper motor neuron abnormality (HP:0002127)2.14661389
61Abnormality of T cell number (HP:0011839)2.13978292
62Emphysema (HP:0002097)2.12422229
63Episodic fever (HP:0001954)2.12233583
64Thick nail (HP:0001805)2.11587524
65Thoracic kyphosis (HP:0002942)2.07724421
66Neurofibrillary tangles (HP:0002185)2.07703933
67Petechiae (HP:0000967)2.06669074
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.06178735
69Osteolytic defects of the hand bones (HP:0009699)2.06178735
70Urethral obstruction (HP:0000796)2.05402814
71Spondylolisthesis (HP:0003302)2.04879151
72Hypochromic microcytic anemia (HP:0004840)2.02985730
73Increased serum ferritin (HP:0003281)2.01098463
74Myositis (HP:0100614)2.01087053
75Agammaglobulinemia (HP:0004432)2.00019983
76Obstructive sleep apnea (HP:0002870)1.99950338
77Verrucae (HP:0200043)1.99668254
78Papilloma (HP:0012740)1.99668254
79Mediastinal lymphadenopathy (HP:0100721)1.99036413
80Segmental peripheral demyelination/remyelination (HP:0003481)1.96762072
81Purpura (HP:0000979)1.93700343
82Arterial thrombosis (HP:0004420)1.92599981
83Gingival bleeding (HP:0000225)1.92385362
84Agnosia (HP:0010524)1.90977787
85Gangrene (HP:0100758)1.89622802
86Pulmonary embolism (HP:0002204)1.88851445
87Increased CSF protein (HP:0002922)1.87109709
88Abnormal platelet function (HP:0011869)1.86666926
89Impaired platelet aggregation (HP:0003540)1.86666926
90Spontaneous hematomas (HP:0007420)1.86442124
91IgM deficiency (HP:0002850)1.86149067
92Abnormality of the thoracic spine (HP:0100711)1.85921684
93Frequent falls (HP:0002359)1.85799466
94Abnormality of iron homeostasis (HP:0011031)1.85618614
95Mitral stenosis (HP:0001718)1.85407830
96Chronic obstructive pulmonary disease (HP:0006510)1.85370678
97Obstructive lung disease (HP:0006536)1.85370678
98Acne (HP:0001061)1.85278340
99Hand muscle atrophy (HP:0009130)1.85164307
100Recurrent bronchitis (HP:0002837)1.85132107
101Malnutrition (HP:0004395)1.84892379
102Abnormality of the pericardium (HP:0001697)1.80887423
103Restrictive lung disease (HP:0002091)1.80154860
104Long eyelashes (HP:0000527)1.80137522
105Sepsis (HP:0100806)1.79655512
106Broad face (HP:0000283)1.79203770
107Meningitis (HP:0001287)1.79152855
108Microcytic anemia (HP:0001935)1.79001861
109Hypergammaglobulinemia (HP:0010702)1.78509359
110Cerebral inclusion bodies (HP:0100314)1.78401737
111Anorexia (HP:0002039)1.77666417
112Pathologic fracture (HP:0002756)1.77421038
113Vasculitis (HP:0002633)1.77030836
114Prominent nose (HP:0000448)1.76755036
115Increased density of long bones (HP:0006392)1.76629743
116Leukocytosis (HP:0001974)1.74924505
117Slow saccadic eye movements (HP:0000514)1.74115638
118Milia (HP:0001056)1.73978513
119Elevated erythrocyte sedimentation rate (HP:0003565)1.73539336
120Abnormality of the endocardium (HP:0004306)1.73105924
121Upper limb amyotrophy (HP:0009129)1.72509900
122Distal upper limb amyotrophy (HP:0007149)1.72509900
123Gastrointestinal stroma tumor (HP:0100723)1.71404852
124Aortic aneurysm (HP:0004942)1.67401175
125Esophageal varix (HP:0002040)1.67310280
126Recurrent cutaneous fungal infections (HP:0011370)1.67073452
127Chronic mucocutaneous candidiasis (HP:0002728)1.67073452
128Aneurysm (HP:0002617)1.66582069
129Hyperacusis (HP:0010780)1.66054149
130Glomerulonephritis (HP:0000099)1.65549810
131Cheilitis (HP:0100825)1.65456728
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65111415
133Abnormality of the nasal mucosa (HP:0000433)1.65081880
134Nasal polyposis (HP:0100582)1.64244117
135Orchitis (HP:0100796)1.64088320
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64086318
137Coarse hair (HP:0002208)1.64017489
138Prolonged bleeding time (HP:0003010)1.63849881
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62188069
140Heterotopia (HP:0002282)1.62160902
141Lymphopenia (HP:0001888)1.62103704
142Urticaria (HP:0001025)1.61828933
143Polycythemia (HP:0001901)1.61575626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.62712394
2MAP4K13.45351680
3ERN13.37372856
4TRIB33.02693879
5CAMK1D2.87440198
6MAP3K102.50242210
7PRPF4B2.41861865
8CAMK1G2.19980465
9PKN22.19338594
10SIK22.03605977
11TYK21.88749844
12MAP2K31.87664835
13EEF2K1.85247711
14STK101.84531178
15SIK11.77514624
16TAOK21.73625069
17TTN1.69193251
18KIT1.65181998
19NEK21.60327657
20TNK21.55454354
21TGFBR21.51468408
22CSF1R1.45457256
23BLK1.44452707
24GRK61.43332575
25JAK11.42001570
26TBK11.41227504
27TAOK31.40246854
28PTK61.35690535
29CDC42BPA1.33121079
30ZAP701.32746040
31RIPK11.31905853
32EPHB11.30737766
33HCK1.30575214
34BRD41.30163852
35CDK61.30015411
36MARK21.29393423
37RIPK41.27545192
38MARK31.25631426
39FGFR41.23214890
40MAP3K11.22929930
41JAK31.18164939
42MTOR1.14128623
43IRAK31.13357618
44TAOK11.12478106
45CSK1.11984982
46CDK41.10420401
47RPS6KA41.09591396
48LRRK21.09485395
49FGFR31.06430659
50PIM11.03243708
51SYK1.01398518
52IRAK11.01147948
53STK31.00961447
54STK40.96589651
55PAK40.96488946
56ALK0.95649603
57MAP3K130.93403929
58BTK0.90284222
59SGK30.89411882
60EPHA20.89117672
61ICK0.88422524
62CHUK0.86860565
63PTK2B0.85931037
64MAP3K60.85107969
65IKBKB0.84933959
66MAP2K60.84772989
67LATS10.84329128
68GRK70.83571484
69HIPK20.82871988
70BMX0.82842192
71JAK20.81663445
72MAP3K20.81310096
73MAPK70.81172844
74MAP3K30.79629358
75FES0.77899129
76TRPM70.77312960
77RPS6KA20.76678629
78CDK90.76649830
79NEK90.75616298
80IKBKE0.74537156
81RPS6KL10.73978350
82RPS6KC10.73978350
83ITK0.73899480
84EPHA30.73386257
85RPS6KA60.73042366
86PRKCH0.71948504
87MAP3K80.71313797
88MAP3K110.69860455
89IRAK20.69723990
90WNK10.68846708
91KSR20.68200978
92LCK0.67482223
93PDGFRB0.62732276
94PRKAA20.60002603
95DAPK20.59431466
96MAPK110.59114707
97MAP3K140.58840622
98DMPK0.56675876
99EGFR0.55759898
100LYN0.54417631
101CAMKK20.53676896
102SGK20.53507758
103MAP3K50.51716035
104IRAK40.51323248
105TXK0.51278170
106SIK30.50667926
107CAMKK10.48135013
108TTK0.47966501
109CLK10.47552790
110DDR20.47277719
111STK380.46583169
112PTK20.46453718
113TEC0.46189910
114PIK3CG0.45286497
115ABL10.44606064
116PDK10.44254267
117FYN0.43635068
118CDK70.42596013
119PRKCQ0.41754530
120MAP3K70.41521742
121MATK0.41233227
122BMPR20.40856664
123MOS0.40645489
124PDGFRA0.40135805
125MAPKAPK20.40132413
126FGR0.39905445
127PRKAA10.38938465
128RET0.38710315
129STK110.38514163
130MAPK120.37978889
131CAMK40.37396412
132PDPK10.37037262
133DYRK1B0.36856559
134PAK20.36450567
135SCYL20.34619973
136ATR0.34187403
137FLT30.34021812
138PRKD20.33743098

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.65130030
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.56121054
3Staphylococcus aureus infection_Homo sapiens_hsa051502.29892374
4Osteoclast differentiation_Homo sapiens_hsa043802.22298763
5Lysosome_Homo sapiens_hsa041422.17889077
6Leishmaniasis_Homo sapiens_hsa051402.02901407
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87650171
8Lysine degradation_Homo sapiens_hsa003101.79893990
9Primary immunodeficiency_Homo sapiens_hsa053401.79735483
10Caffeine metabolism_Homo sapiens_hsa002321.77684141
11Graft-versus-host disease_Homo sapiens_hsa053321.77010032
12Other glycan degradation_Homo sapiens_hsa005111.73320423
13Chronic myeloid leukemia_Homo sapiens_hsa052201.71880251
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.69566051
15Allograft rejection_Homo sapiens_hsa053301.65330825
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60174281
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54469980
18Tuberculosis_Homo sapiens_hsa051521.52126645
19Autoimmune thyroid disease_Homo sapiens_hsa053201.50331412
20Acute myeloid leukemia_Homo sapiens_hsa052211.46623039
21Measles_Homo sapiens_hsa051621.33901370
22Apoptosis_Homo sapiens_hsa042101.33235621
23Toxoplasmosis_Homo sapiens_hsa051451.28891734
24mTOR signaling pathway_Homo sapiens_hsa041501.28690136
25Antigen processing and presentation_Homo sapiens_hsa046121.27680686
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.26034010
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24947986
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23947611
29Rheumatoid arthritis_Homo sapiens_hsa053231.18870820
30Pancreatic cancer_Homo sapiens_hsa052121.18554278
31Insulin resistance_Homo sapiens_hsa049311.18525212
32Hematopoietic cell lineage_Homo sapiens_hsa046401.16473075
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.16416025
34Small cell lung cancer_Homo sapiens_hsa052221.13915645
35Influenza A_Homo sapiens_hsa051641.13470619
36Type I diabetes mellitus_Homo sapiens_hsa049401.12936906
37Non-small cell lung cancer_Homo sapiens_hsa052231.11803396
38T cell receptor signaling pathway_Homo sapiens_hsa046601.11422858
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.10650396
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09252444
41Hepatitis B_Homo sapiens_hsa051611.07582066
42Notch signaling pathway_Homo sapiens_hsa043301.06078893
43Herpes simplex infection_Homo sapiens_hsa051681.05760872
44Asthma_Homo sapiens_hsa053101.02736238
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02599917
46MicroRNAs in cancer_Homo sapiens_hsa052061.00481739
47African trypanosomiasis_Homo sapiens_hsa051431.00015050
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.99942464
49Pertussis_Homo sapiens_hsa051330.97861878
50Proteoglycans in cancer_Homo sapiens_hsa052050.96027665
51Shigellosis_Homo sapiens_hsa051310.94073301
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91432414
53Platelet activation_Homo sapiens_hsa046110.91256567
54Malaria_Homo sapiens_hsa051440.91203841
55GnRH signaling pathway_Homo sapiens_hsa049120.90848169
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90501159
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.88601640
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88377125
59Chemokine signaling pathway_Homo sapiens_hsa040620.87635467
60HIF-1 signaling pathway_Homo sapiens_hsa040660.87139643
61Dorso-ventral axis formation_Homo sapiens_hsa043200.87066937
62TNF signaling pathway_Homo sapiens_hsa046680.86973970
63FoxO signaling pathway_Homo sapiens_hsa040680.86056797
64Complement and coagulation cascades_Homo sapiens_hsa046100.85975713
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85915253
66Type II diabetes mellitus_Homo sapiens_hsa049300.85812871
67Renal cell carcinoma_Homo sapiens_hsa052110.85618817
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85036674
69VEGF signaling pathway_Homo sapiens_hsa043700.83851613
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83834453
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83160292
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82915848
73Hepatitis C_Homo sapiens_hsa051600.82493882
74Viral myocarditis_Homo sapiens_hsa054160.81214768
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79909747
76HTLV-I infection_Homo sapiens_hsa051660.79505198
77Viral carcinogenesis_Homo sapiens_hsa052030.79331745
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78944480
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.78702460
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76826969
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76668963
82Prolactin signaling pathway_Homo sapiens_hsa049170.74629078
83Adherens junction_Homo sapiens_hsa045200.74515270
84Legionellosis_Homo sapiens_hsa051340.73687165
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73515749
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73148576
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73063049
88Amoebiasis_Homo sapiens_hsa051460.72058552
89Inositol phosphate metabolism_Homo sapiens_hsa005620.70465044
90Nitrogen metabolism_Homo sapiens_hsa009100.70286817
91PPAR signaling pathway_Homo sapiens_hsa033200.70257790
92Insulin signaling pathway_Homo sapiens_hsa049100.69891959
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69134384
94p53 signaling pathway_Homo sapiens_hsa041150.69084353
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.68081431
96Endocytosis_Homo sapiens_hsa041440.67625268
97MAPK signaling pathway_Homo sapiens_hsa040100.67058052
98AMPK signaling pathway_Homo sapiens_hsa041520.66361225
99Choline metabolism in cancer_Homo sapiens_hsa052310.64030510
100Salmonella infection_Homo sapiens_hsa051320.62935534
101Glycerolipid metabolism_Homo sapiens_hsa005610.61583277
102Endometrial cancer_Homo sapiens_hsa052130.60599293
103Glioma_Homo sapiens_hsa052140.60539066
104Bladder cancer_Homo sapiens_hsa052190.60404982
105Focal adhesion_Homo sapiens_hsa045100.60250477
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60164356
107Colorectal cancer_Homo sapiens_hsa052100.59844140
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59401657
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58497488
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56570276
111Prostate cancer_Homo sapiens_hsa052150.56488245
112Vitamin B6 metabolism_Homo sapiens_hsa007500.56207155
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.54996805
114Phagosome_Homo sapiens_hsa041450.54522791
115Epstein-Barr virus infection_Homo sapiens_hsa051690.53934801
116ErbB signaling pathway_Homo sapiens_hsa040120.52641096
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.52370053
118Pentose phosphate pathway_Homo sapiens_hsa000300.52053286
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50463100
120ABC transporters_Homo sapiens_hsa020100.49812242
121Rap1 signaling pathway_Homo sapiens_hsa040150.49807611
122Estrogen signaling pathway_Homo sapiens_hsa049150.49141025
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48416714
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45345283
125Ras signaling pathway_Homo sapiens_hsa040140.44438784
126Collecting duct acid secretion_Homo sapiens_hsa049660.43648342
127Sphingolipid metabolism_Homo sapiens_hsa006000.40322066

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