PLEKHM1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.35976513
2negative regulation of cell killing (GO:0031342)5.09515164
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.09515164
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69649863
5regulation of gamma-delta T cell activation (GO:0046643)4.50209235
6regulation of gamma-delta T cell differentiation (GO:0045586)4.24731559
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19508434
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.19508434
9modulation by symbiont of host immune response (GO:0052553)4.19508434
10positive regulation by symbiont of host defense response (GO:0052509)4.19508434
11modulation by symbiont of host defense response (GO:0052031)4.19508434
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19508434
13regulation of B cell receptor signaling pathway (GO:0050855)4.09609841
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08764314
15antigen processing and presentation of endogenous antigen (GO:0019883)4.03218246
16cellular extravasation (GO:0045123)4.02502965
17macrophage activation involved in immune response (GO:0002281)3.84746041
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77927653
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73741806
20negative thymic T cell selection (GO:0045060)3.73117462
21detection of other organism (GO:0098543)3.71773957
22negative regulation of T cell mediated immunity (GO:0002710)3.70739756
23negative T cell selection (GO:0043383)3.66663101
24activated T cell proliferation (GO:0050798)3.65193065
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.62919042
26detection of bacterium (GO:0016045)3.60180913
27response to peptidoglycan (GO:0032494)3.52369307
28tolerance induction (GO:0002507)3.46618559
29neutrophil activation involved in immune response (GO:0002283)3.46114686
30negative regulation of interleukin-12 production (GO:0032695)3.45458965
31leukocyte aggregation (GO:0070486)3.44931720
32regulation of interferon-beta biosynthetic process (GO:0045357)3.43477810
33positive thymic T cell selection (GO:0045059)3.42902415
34response to muramyl dipeptide (GO:0032495)3.41564138
35neutrophil activation (GO:0042119)3.37973660
36response to interleukin-15 (GO:0070672)3.34214653
37microglial cell activation (GO:0001774)3.21845864
38T cell selection (GO:0045058)3.20438508
39positive T cell selection (GO:0043368)3.18350292
40cellular response to interleukin-15 (GO:0071350)3.17118226
41B cell receptor signaling pathway (GO:0050853)3.15611501
42regulation of mast cell activation (GO:0033003)3.13809562
43negative regulation of leukocyte mediated immunity (GO:0002704)3.12041971
44detection of external biotic stimulus (GO:0098581)3.11185802
45regulation of T cell mediated cytotoxicity (GO:0001914)3.10057117
46positive regulation of mast cell activation (GO:0033005)3.07897359
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04399199
48granulocyte activation (GO:0036230)3.02408332
49regulation of B cell differentiation (GO:0045577)3.02345897
50thymic T cell selection (GO:0045061)3.00934566
51regulation of mast cell degranulation (GO:0043304)3.00370660
52myeloid cell activation involved in immune response (GO:0002275)3.00048131
53positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98666156
54germinal center formation (GO:0002467)2.97710853
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94695586
56detection of molecule of bacterial origin (GO:0032490)2.93868543
57negative regulation of interleukin-6 production (GO:0032715)2.93714311
58macrophage activation (GO:0042116)2.91324635
59regulation of mast cell activation involved in immune response (GO:0033006)2.90912674
60response to host immune response (GO:0052572)2.89716306
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89716306
62antigen processing and presentation via MHC class Ib (GO:0002475)2.87004136
63positive regulation of granulocyte differentiation (GO:0030854)2.85810470
64regulation of interleukin-12 biosynthetic process (GO:0045075)2.83378350
65negative regulation of interleukin-1 production (GO:0032692)2.82156233
66defense response to protozoan (GO:0042832)2.81424221
67detection of biotic stimulus (GO:0009595)2.81154793
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80070784
69regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79355908
70regulation of MHC class I biosynthetic process (GO:0045343)2.77996468
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77738721
72interferon-gamma production (GO:0032609)2.73354170
73neutrophil mediated immunity (GO:0002446)2.72631013
74cellular response to exogenous dsRNA (GO:0071360)2.71762165
75immunoglobulin mediated immune response (GO:0016064)2.71673631
76positive regulation of CREB transcription factor activity (GO:0032793)2.71533764
77leukocyte degranulation (GO:0043299)2.69940912
78positive regulation of mast cell degranulation (GO:0043306)2.69024953
79positive regulation of mast cell activation involved in immune response (GO:0033008)2.69024953
80mannose metabolic process (GO:0006013)2.69018734
81response to host (GO:0075136)2.68237496
82response to host defenses (GO:0052200)2.68237496
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68237496
84dendritic cell migration (GO:0036336)2.67220175
85regulation of alpha-beta T cell proliferation (GO:0046640)2.67049350
86regulation of regulatory T cell differentiation (GO:0045589)2.66269940
87histone H3-K4 trimethylation (GO:0080182)2.66093904
88positive regulation of B cell differentiation (GO:0045579)2.66067343
89T cell migration (GO:0072678)2.66043180
90regulation of tolerance induction (GO:0002643)2.66040279
91negative regulation of interleukin-1 beta production (GO:0032691)2.65940552
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65865967
93positive regulation of antigen processing and presentation (GO:0002579)2.65663277
94negative regulation of erythrocyte differentiation (GO:0045647)2.65258305
95response to protozoan (GO:0001562)2.63188299
96mast cell activation (GO:0045576)2.60641896
97regulation of T cell tolerance induction (GO:0002664)2.58812798
98cellular response to ethanol (GO:0071361)2.57834816
99negative regulation of adaptive immune response (GO:0002820)2.57274804
100response to type I interferon (GO:0034340)2.57157318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.97322388
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26986396
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.03266969
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84681409
5RUNX_20019798_ChIP-Seq_JUKART_Human2.79160458
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.62503194
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.57968042
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51471974
9SCL_19346495_ChIP-Seq_HPC-7_Human2.42567539
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37209031
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.21765228
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16029890
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11247111
14DROSHA_22980978_ChIP-Seq_HELA_Human2.02049634
15SPI1_23127762_ChIP-Seq_K562_Human1.97483754
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90316280
17VDR_24763502_ChIP-Seq_THP-1_Human1.88576743
18MYB_26560356_Chip-Seq_TH2_Human1.88114119
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87802574
20VDR_21846776_ChIP-Seq_THP-1_Human1.87772924
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83012549
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77248008
23VDR_24787735_ChIP-Seq_THP-1_Human1.70255570
24MAF_26560356_Chip-Seq_TH1_Human1.66750427
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65126981
26GATA3_27048872_Chip-Seq_THYMUS_Human1.61467078
27MYB_26560356_Chip-Seq_TH1_Human1.57555404
28UTX_26944678_Chip-Seq_JUKART_Human1.55527526
29TCF7_22412390_ChIP-Seq_EML_Mouse1.52956156
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51102914
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50740626
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49278014
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.49112215
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.48066826
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47525270
36GATA3_26560356_Chip-Seq_TH2_Human1.47371826
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44542113
38KDM2B_26808549_Chip-Seq_DND41_Human1.43535003
39SPI1_23547873_ChIP-Seq_NB4_Human1.42521214
40MAF_26560356_Chip-Seq_TH2_Human1.42367152
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37770304
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33863912
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32719232
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32050967
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31050961
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27794686
47MYC_22102868_ChIP-Seq_BL_Human1.27521757
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27320900
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26757088
50GATA1_19941826_ChIP-Seq_K562_Human1.26684431
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26198090
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22917573
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22168362
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21768792
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20078820
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17925945
57BCL6_27268052_Chip-Seq_Bcells_Human1.16597581
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14765521
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.14596962
60BCOR_27268052_Chip-Seq_Bcells_Human1.09226107
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07581046
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.05709346
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.04930723
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02535458
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01572589
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00564739
67KDM2B_26808549_Chip-Seq_JURKAT_Human0.98296482
68P300_27268052_Chip-Seq_Bcells_Human0.97215092
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95968670
70SMRT_27268052_Chip-Seq_Bcells_Human0.95662867
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95031354
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94413490
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94321444
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94260034
75P68_20966046_ChIP-Seq_HELA_Human0.93801736
76GATA2_19941826_ChIP-Seq_K562_Human0.92462904
77RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92434067
78OCT4_19829295_ChIP-Seq_ESCs_Human0.92216872
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91685374
80LXR_22292898_ChIP-Seq_THP-1_Human0.91162170
81ZNF274_21170338_ChIP-Seq_K562_Hela0.90698057
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90019121
83E2F1_20622854_ChIP-Seq_HELA_Human0.89583312
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.88761882
85AHR_22903824_ChIP-Seq_MCF-7_Human0.87355113
86ERA_21632823_ChIP-Seq_H3396_Human0.86826758
87GATA1_22025678_ChIP-Seq_K562_Human0.85927098
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84807800
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81991986
90SMC4_20622854_ChIP-Seq_HELA_Human0.81875074
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81757681
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81411362
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81153683
94TP63_22573176_ChIP-Seq_HFKS_Human0.80376367
95PHF8_20622854_ChIP-Seq_HELA_Human0.79851836
96RAC3_21632823_ChIP-Seq_H3396_Human0.79837202
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79706876
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79321974
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79128734
100PU_27001747_Chip-Seq_BMDM_Mouse0.78768106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.01155232
2MP0003436_decreased_susceptibility_to4.00041639
3MP0001835_abnormal_antigen_presentation3.33229288
4MP0001800_abnormal_humoral_immune3.03408035
5MP0005671_abnormal_response_to2.97656282
6MP0000685_abnormal_immune_system2.87152440
7MP0001790_abnormal_immune_system2.79195522
8MP0005387_immune_system_phenotype2.79195522
9MP0002419_abnormal_innate_immunity2.71231749
10MP0003303_peritoneal_inflammation2.64445521
11MP0005000_abnormal_immune_tolerance2.59187548
12MP0003763_abnormal_thymus_physiology2.57200477
13MP0002723_abnormal_immune_serum2.54257770
14MP0005025_abnormal_response_to2.53848248
15MP0003172_abnormal_lysosome_physiology2.43016296
16MP0002452_abnormal_antigen_presenting2.42319628
17MP0002420_abnormal_adaptive_immunity2.39752978
18MP0001819_abnormal_immune_cell2.37826485
19MP0009785_altered_susceptibility_to2.27372123
20MP0006082_CNS_inflammation2.18216085
21MP0000569_abnormal_digit_pigmentation2.13565284
22MP0002405_respiratory_system_inflammati2.01378178
23MP0001533_abnormal_skeleton_physiology2.00853397
24MP0002148_abnormal_hypersensitivity_rea2.00320541
25MP0004381_abnormal_hair_follicle1.94420024
26MP0003866_abnormal_defecation1.85452518
27MP0000716_abnormal_immune_system1.82166591
28MP0001873_stomach_inflammation1.81985640
29MP0001986_abnormal_taste_sensitivity1.79294840
30MP0004947_skin_inflammation1.73580433
31MP0002398_abnormal_bone_marrow1.72315459
32MP0010155_abnormal_intestine_physiology1.69119840
33MP0009278_abnormal_bone_marrow1.64261155
34MP0009764_decreased_sensitivity_to1.61881417
35MP0005310_abnormal_salivary_gland1.55955007
36MP0001845_abnormal_inflammatory_respons1.54363135
37MP0002933_joint_inflammation1.52628688
38MP0000689_abnormal_spleen_morphology1.47116823
39MP0003828_pulmonary_edema1.46479563
40MP0003045_fibrosis1.44979452
41MP0005464_abnormal_platelet_physiology1.40942661
42MP0009333_abnormal_splenocyte_physiolog1.40307393
43MP0003300_gastrointestinal_ulcer1.37508369
44MP0002722_abnormal_immune_system1.36194097
45MP0002429_abnormal_blood_cell1.34303289
46MP0002138_abnormal_hepatobiliary_system1.29229271
47MP0003646_muscle_fatigue1.28577952
48MP0000703_abnormal_thymus_morphology1.27902339
49MP0004130_abnormal_muscle_cell1.27228001
50MP0000465_gastrointestinal_hemorrhage1.25703135
51MP0003183_abnormal_peptide_metabolism1.24300415
52MP0008469_abnormal_protein_level1.21230850
53MP0004883_abnormal_blood_vessel1.19319998
54MP0001663_abnormal_digestive_system1.18846086
55MP0002998_abnormal_bone_remodeling1.16114400
56MP0000015_abnormal_ear_pigmentation1.15100063
57MP0008961_abnormal_basal_metabolism1.12468656
58MP0002166_altered_tumor_susceptibility1.11560211
59MP0002653_abnormal_ependyma_morphology1.09490586
60MP0005377_hearing/vestibular/ear_phenot1.08992085
61MP0003878_abnormal_ear_physiology1.08992085
62MP0001851_eye_inflammation1.07732957
63MP0001501_abnormal_sleep_pattern1.05830226
64MP0002009_preneoplasia1.05791694
65MP0005397_hematopoietic_system_phenotyp1.05496482
66MP0001545_abnormal_hematopoietic_system1.05496482
67MP0003191_abnormal_cellular_cholesterol1.05045974
68MP0002396_abnormal_hematopoietic_system1.01528612
69MP0005075_abnormal_melanosome_morpholog1.01152530
70MP0004510_myositis0.99041532
71MP0002277_abnormal_respiratory_mucosa0.98986291
72MP0004043_abnormal_pH_regulation0.98665630
73MP0002132_abnormal_respiratory_system0.98324457
74MP0005167_abnormal_blood-brain_barrier0.93875323
75MP0005058_abnormal_lysosome_morphology0.92896770
76MP0005174_abnormal_tail_pigmentation0.89694655
77MP0005390_skeleton_phenotype0.84747150
78MP0005164_abnormal_response_to0.83689417
79MP0003195_calcinosis0.81804101
80MP0000470_abnormal_stomach_morphology0.81623704
81MP0002928_abnormal_bile_duct0.81583326
82MP0008004_abnormal_stomach_pH0.81023280
83MP0001765_abnormal_ion_homeostasis0.81014494
84MP0008260_abnormal_autophagy0.79734707
85MP0000249_abnormal_blood_vessel0.79086911
86MP0005076_abnormal_cell_differentiation0.78696575
87MP0000371_diluted_coat_color0.77960934
88MP0008995_early_reproductive_senescence0.75079423
89MP0002693_abnormal_pancreas_physiology0.72326885
90MP0005083_abnormal_biliary_tract0.68828468
91MP0003252_abnormal_bile_duct0.68369638
92MP0005381_digestive/alimentary_phenotyp0.67393661
93MP0009115_abnormal_fat_cell0.65260019
94MP0002332_abnormal_exercise_endurance0.64526745
95MP0003656_abnormal_erythrocyte_physiolo0.63477329
96MP0003690_abnormal_glial_cell0.63435766
97MP0000427_abnormal_hair_cycle0.63345168
98MP0002136_abnormal_kidney_physiology0.61525601
99MP0004742_abnormal_vestibular_system0.59482391
100MP0001958_emphysema0.58285036

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.80000359
2Eczematoid dermatitis (HP:0000976)4.79509581
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.50784049
4Retrobulbar optic neuritis (HP:0100654)4.37609463
5Optic neuritis (HP:0100653)4.37609463
6Elevated erythrocyte sedimentation rate (HP:0003565)4.35012163
7Orchitis (HP:0100796)4.32405543
8Recurrent bacterial skin infections (HP:0005406)4.25496369
9Stomatitis (HP:0010280)4.21450196
10Recurrent fungal infections (HP:0002841)4.12090903
11Recurrent abscess formation (HP:0002722)4.04638234
12Recurrent cutaneous fungal infections (HP:0011370)3.85117949
13Chronic mucocutaneous candidiasis (HP:0002728)3.85117949
14Pustule (HP:0200039)3.55134681
15Abnormality of macrophages (HP:0004311)3.54332040
16Gastrointestinal infarctions (HP:0005244)3.47141456
17Recurrent skin infections (HP:0001581)3.29652948
18Encephalitis (HP:0002383)3.22796143
19Increased IgE level (HP:0003212)3.12501457
20Panhypogammaglobulinemia (HP:0003139)3.10107865
21Keratoconjunctivitis sicca (HP:0001097)3.05740863
22Recurrent gram-negative bacterial infections (HP:0005420)3.04988388
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.02224631
24Abnormality of T cell number (HP:0011839)3.01875450
25Keratoconjunctivitis (HP:0001096)2.99645439
26Meningitis (HP:0001287)2.98631861
27Mediastinal lymphadenopathy (HP:0100721)2.95540478
28Abnormality of the fingertips (HP:0001211)2.94773851
29Hemoptysis (HP:0002105)2.93992944
30Vasculitis (HP:0002633)2.89631337
31T lymphocytopenia (HP:0005403)2.89148913
32Colitis (HP:0002583)2.86627939
33Autoimmune thrombocytopenia (HP:0001973)2.84120006
34Hypochromic anemia (HP:0001931)2.83252128
35Genetic anticipation (HP:0003743)2.81157447
36Stomach cancer (HP:0012126)2.80104041
37Prolonged bleeding time (HP:0003010)2.79788863
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.78822339
39Abnormality of T cells (HP:0002843)2.78634537
40Inflammation of the large intestine (HP:0002037)2.76949591
41Increased cerebral lipofuscin (HP:0011813)2.70700177
42Gingivitis (HP:0000230)2.60268250
43Gastrointestinal inflammation (HP:0004386)2.60091951
44Abnormality of T cell physiology (HP:0011840)2.59180495
45Pulmonary infiltrates (HP:0002113)2.58834045
46Recurrent viral infections (HP:0004429)2.50890921
47Leukocytosis (HP:0001974)2.50599734
48Spontaneous hematomas (HP:0007420)2.49932884
49Obstructive lung disease (HP:0006536)2.47035403
50Chronic obstructive pulmonary disease (HP:0006510)2.47035403
51Clumsiness (HP:0002312)2.41395687
52Hypochromic microcytic anemia (HP:0004840)2.37058748
53Chest pain (HP:0100749)2.35258613
54Cheilitis (HP:0100825)2.27224449
55Granulocytopenia (HP:0001913)2.22275895
56Agammaglobulinemia (HP:0004432)2.20691803
57Episodic fever (HP:0001954)2.13996632
58Dysostosis multiplex (HP:0000943)2.10569394
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10069037
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10069037
61Abnormality of polysaccharide metabolism (HP:0011012)2.10069037
62Epistaxis (HP:0000421)2.08393105
63Arterial thrombosis (HP:0004420)2.06351777
64Abnormality of the pleura (HP:0002103)2.04196814
65Eosinophilia (HP:0001880)2.01984870
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01136060
67Recurrent bronchitis (HP:0002837)2.00342269
68Abnormality of eosinophils (HP:0001879)1.99946413
69Autoimmune hemolytic anemia (HP:0001890)1.99421477
70Anorexia (HP:0002039)1.98748470
71Progressive cerebellar ataxia (HP:0002073)1.97744356
72Pulmonary embolism (HP:0002204)1.95243892
73Keratitis (HP:0000491)1.94670838
74Urticaria (HP:0001025)1.94289072
75Urinary glycosaminoglycan excretion (HP:0003541)1.90513646
76Mucopolysacchariduria (HP:0008155)1.90513646
77Hyperventilation (HP:0002883)1.89741521
78Decreased circulating renin level (HP:0003351)1.88820229
79Abnormality of transition element cation homeostasis (HP:0011030)1.86177239
80Gangrene (HP:0100758)1.85983009
81Abnormality of the endocardium (HP:0004306)1.84189823
82Hematochezia (HP:0002573)1.82840933
83Gingival bleeding (HP:0000225)1.79907929
84Congenital stationary night blindness (HP:0007642)1.79317536
85Peritonitis (HP:0002586)1.78822871
86Abnormality of iron homeostasis (HP:0011031)1.78558371
87Cellulitis (HP:0100658)1.78124535
88Increased serum ferritin (HP:0003281)1.78102281
89Vertigo (HP:0002321)1.72715906
90Broad face (HP:0000283)1.71313799
91Obstructive sleep apnea (HP:0002870)1.68059600
92Amyloidosis (HP:0011034)1.67508307
93Widely spaced teeth (HP:0000687)1.66920921
94Supernumerary bones of the axial skeleton (HP:0009144)1.65692181
95Hemiplegia (HP:0002301)1.64994682
96Alveolar cell carcinoma (HP:0006519)1.63680874
97Increased IgM level (HP:0003496)1.63514207
98Acne (HP:0001061)1.63396692
99Neoplasm of the tracheobronchial system (HP:0100552)1.63165874
100Malnutrition (HP:0004395)1.62881903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.50715615
2RIPK43.16368550
3BLK2.74063992
4TAOK32.70635182
5TXK2.63463442
6TNK22.34801597
7FRK2.18886842
8TYK22.05119468
9IRAK42.01356454
10ZAP702.01142128
11MAP2K31.92472821
12GRK61.90622122
13FES1.90022226
14BTK1.68176604
15CSK1.66235062
16SIK21.63988080
17JAK31.63149940
18SYK1.61085965
19TRIB31.60185371
20IKBKE1.59432281
21ERN11.56572360
22ITK1.42102198
23KIT1.41715879
24HCK1.39044418
25MAP3K71.35882962
26MARK21.35724482
27EPHB11.35029892
28MAP3K141.32125058
29IKBKB1.26868617
30JAK11.25905837
31MAP3K131.24039755
32WNK41.22918987
33DAPK21.21265205
34LCK1.18634927
35ADRBK21.17172332
36TBK11.15208246
37MAP2K61.13137040
38MAP3K31.12313013
39CSF1R1.11319386
40CDC42BPA1.10572898
41PRPF4B1.10365618
42IRAK11.06563228
43LYN1.05295464
44TEC1.03368385
45MARK30.99257879
46WNK10.97925630
47SIK10.96867376
48PRKD20.95447610
49CHUK0.94326315
50ACVR1B0.90894685
51SIK30.90711246
52JAK20.90362642
53MAPK150.90116277
54PTK60.88141569
55PTK2B0.87985959
56PIK3CG0.87635762
57MAP3K60.87421251
58INSRR0.87385788
59TAOK10.87321911
60PDK10.83880000
61TRPM70.83509717
62MAP3K110.83227033
63CAMKK10.82230255
64HIPK20.79934356
65FGR0.79741579
66MAPK70.76996178
67CAMK1D0.76411352
68RPS6KA60.74253703
69PDPK10.71967252
70MAPK120.71921246
71TLK10.71498264
72PRKCQ0.71372001
73SGK20.66085249
74CAMKK20.65107133
75EPHA30.65013786
76MAP2K20.64162018
77CAMK40.64054578
78MAP4K20.63652989
79PRKAA20.63317941
80STK380.62886153
81MATK0.62444306
82NLK0.62182792
83ERBB20.61410936
84FGFR30.57483688
85MAPKAPK30.56135591
86RPS6KL10.55777921
87RPS6KC10.55777921
88ADRBK10.54643830
89STK110.53074103
90PDGFRB0.52446566
91MAP3K10.51634956
92PIK3CA0.51554578
93SGK30.50645347
94CDK120.48978677
95RPS6KA20.48904309
96IRAK20.47390926
97MAPK110.47190658
98TGFBR20.45895046
99BMPR1B0.45853434
100BMPR20.45679881

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.27535781
2Staphylococcus aureus infection_Homo sapiens_hsa051502.12801528
3Primary immunodeficiency_Homo sapiens_hsa053402.12522708
4Graft-versus-host disease_Homo sapiens_hsa053322.10617333
5Leishmaniasis_Homo sapiens_hsa051402.08408730
6Allograft rejection_Homo sapiens_hsa053301.92088379
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86454575
8B cell receptor signaling pathway_Homo sapiens_hsa046621.85709208
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.84456381
10Autoimmune thyroid disease_Homo sapiens_hsa053201.81252447
11T cell receptor signaling pathway_Homo sapiens_hsa046601.79756879
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78117659
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75065188
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74308368
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.68867805
16Other glycan degradation_Homo sapiens_hsa005111.53567586
17Tuberculosis_Homo sapiens_hsa051521.53401016
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51912702
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51393115
20Acute myeloid leukemia_Homo sapiens_hsa052211.49278706
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47777880
22Type I diabetes mellitus_Homo sapiens_hsa049401.45775932
23Hematopoietic cell lineage_Homo sapiens_hsa046401.44502223
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39336645
25TNF signaling pathway_Homo sapiens_hsa046681.36079944
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.36053297
27Asthma_Homo sapiens_hsa053101.34757982
28Measles_Homo sapiens_hsa051621.28709931
29Malaria_Homo sapiens_hsa051441.27949449
30Chemokine signaling pathway_Homo sapiens_hsa040621.27831287
31Toxoplasmosis_Homo sapiens_hsa051451.24623505
32Platelet activation_Homo sapiens_hsa046111.19561377
33Dorso-ventral axis formation_Homo sapiens_hsa043201.17361249
34Antigen processing and presentation_Homo sapiens_hsa046121.16897034
35Influenza A_Homo sapiens_hsa051641.15474108
36ABC transporters_Homo sapiens_hsa020101.12685347
37Linoleic acid metabolism_Homo sapiens_hsa005911.10935948
38VEGF signaling pathway_Homo sapiens_hsa043701.08828420
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08116940
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05026383
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00850316
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.98454727
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.97008604
44Notch signaling pathway_Homo sapiens_hsa043300.94365916
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94298292
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93731931
47African trypanosomiasis_Homo sapiens_hsa051430.92224973
48Choline metabolism in cancer_Homo sapiens_hsa052310.91402903
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91002852
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90013000
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.89549213
52Herpes simplex infection_Homo sapiens_hsa051680.87515368
53Ether lipid metabolism_Homo sapiens_hsa005650.85410183
54Prolactin signaling pathway_Homo sapiens_hsa049170.84437966
55GnRH signaling pathway_Homo sapiens_hsa049120.81823143
56Lysosome_Homo sapiens_hsa041420.81099058
57Pertussis_Homo sapiens_hsa051330.80921512
58Non-small cell lung cancer_Homo sapiens_hsa052230.80677627
59Hepatitis B_Homo sapiens_hsa051610.79963660
60Hepatitis C_Homo sapiens_hsa051600.78043860
61Rheumatoid arthritis_Homo sapiens_hsa053230.77176123
62Viral myocarditis_Homo sapiens_hsa054160.75808669
63Legionellosis_Homo sapiens_hsa051340.74701872
64Insulin resistance_Homo sapiens_hsa049310.74206275
65Inositol phosphate metabolism_Homo sapiens_hsa005620.74156709
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72878744
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.72834796
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.72724416
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72057882
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71814911
71Type II diabetes mellitus_Homo sapiens_hsa049300.71613446
72Regulation of autophagy_Homo sapiens_hsa041400.70566133
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70416453
74FoxO signaling pathway_Homo sapiens_hsa040680.69943858
75MAPK signaling pathway_Homo sapiens_hsa040100.68064406
76mTOR signaling pathway_Homo sapiens_hsa041500.67828497
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.65848748
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64339210
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.63345518
80Ovarian steroidogenesis_Homo sapiens_hsa049130.62967292
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62814784
82Phagosome_Homo sapiens_hsa041450.61034174
83Arachidonic acid metabolism_Homo sapiens_hsa005900.57728033
84Apoptosis_Homo sapiens_hsa042100.56523118
85Renal cell carcinoma_Homo sapiens_hsa052110.55831269
86Glycerolipid metabolism_Homo sapiens_hsa005610.54518801
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54456083
88Chronic myeloid leukemia_Homo sapiens_hsa052200.54300527
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53965989
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.53591222
91Morphine addiction_Homo sapiens_hsa050320.49280392
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48076216
93Cholinergic synapse_Homo sapiens_hsa047250.47867583
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47104685
95Salivary secretion_Homo sapiens_hsa049700.46557698
96Endocytosis_Homo sapiens_hsa041440.45971964
97Oxytocin signaling pathway_Homo sapiens_hsa049210.45485673
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45135836
99Pancreatic cancer_Homo sapiens_hsa052120.44695529
100Estrogen signaling pathway_Homo sapiens_hsa049150.44562255

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