PLEKHM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.44169273
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.38864285
3plasma membrane repair (GO:0001778)4.24459290
4sodium ion export (GO:0071436)4.09968832
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.96249402
6cell communication by electrical coupling (GO:0010644)3.91227852
7synaptic vesicle maturation (GO:0016188)3.90481743
8negative regulation of potassium ion transmembrane transport (GO:1901380)3.83889533
9regulation of synapse structural plasticity (GO:0051823)3.75482725
10regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.73539046
11locomotory exploration behavior (GO:0035641)3.68516874
12cardiac myofibril assembly (GO:0055003)3.63863004
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63593272
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.61773437
15positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.57606045
16negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.53938900
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50241726
18regulation of early endosome to late endosome transport (GO:2000641)3.49659353
19response to peptidoglycan (GO:0032494)3.48685729
20barbed-end actin filament capping (GO:0051016)3.48105199
21mannose metabolic process (GO:0006013)3.46593635
22potassium ion import (GO:0010107)3.45958045
23cellular potassium ion homeostasis (GO:0030007)3.45491814
24sarcomere organization (GO:0045214)3.44582966
25cardiac muscle contraction (GO:0060048)3.42448295
26cell communication involved in cardiac conduction (GO:0086065)3.39356942
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.36785177
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25587960
29regulation of ARF protein signal transduction (GO:0032012)3.24424979
30cellular response to thyroid hormone stimulus (GO:0097067)3.22364021
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.21604466
32activation of protein kinase A activity (GO:0034199)3.20001205
33myofibril assembly (GO:0030239)3.13588922
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11615259
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04790160
36regulation of membrane repolarization (GO:0060306)3.03251423
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02784336
38regulation of T-helper 2 cell differentiation (GO:0045628)2.99876051
39response to muramyl dipeptide (GO:0032495)2.98734844
40positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.98729209
41macrophage activation involved in immune response (GO:0002281)2.98078700
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95233212
43regulation of actin filament-based movement (GO:1903115)2.91495745
44glycosphingolipid catabolic process (GO:0046479)2.91036666
45cytoskeletal anchoring at plasma membrane (GO:0007016)2.89334395
46activation of MAPKKK activity (GO:0000185)2.87849243
47regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86362362
48regulation of calcium ion transmembrane transport (GO:1903169)2.86362362
49relaxation of cardiac muscle (GO:0055119)2.83475183
50negative regulation of interleukin-12 production (GO:0032695)2.83460464
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82275822
52adenosine receptor signaling pathway (GO:0001973)2.80815263
53synaptic vesicle docking involved in exocytosis (GO:0016081)2.80292949
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77865654
55germinal center formation (GO:0002467)2.77795016
56membrane depolarization during action potential (GO:0086010)2.72637177
57positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72317359
58L-amino acid import (GO:0043092)2.69489025
59cardiac muscle hypertrophy (GO:0003300)2.69312769
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68165247
61positive regulation of protein dephosphorylation (GO:0035307)2.68000635
62regulation of the force of heart contraction (GO:0002026)2.64840233
63regulation of leukocyte degranulation (GO:0043300)2.64626394
64ventricular cardiac muscle cell action potential (GO:0086005)2.63079798
65regulation of p38MAPK cascade (GO:1900744)2.61324999
66striated muscle hypertrophy (GO:0014897)2.60676845
67regulation of ARF GTPase activity (GO:0032312)2.60543579
68synaptic vesicle exocytosis (GO:0016079)2.60484586
69adhesion of symbiont to host cell (GO:0044650)2.59202612
70virion attachment to host cell (GO:0019062)2.59202612
71stress fiber assembly (GO:0043149)2.59027804
72sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57415377
73positive regulation of potassium ion transmembrane transport (GO:1901381)2.57184857
74response to laminar fluid shear stress (GO:0034616)2.57087700
75regulation of glutamate receptor signaling pathway (GO:1900449)2.56550455
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56530063
77positive regulation by organism of defense response of other organism involved in symbiotic interact2.56530063
78modulation by symbiont of host immune response (GO:0052553)2.56530063
79positive regulation by symbiont of host defense response (GO:0052509)2.56530063
80modulation by symbiont of host defense response (GO:0052031)2.56530063
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56530063
82signal complex assembly (GO:0007172)2.56206191
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55270415
84layer formation in cerebral cortex (GO:0021819)2.54661854
85pinocytosis (GO:0006907)2.54542468
86glycolipid catabolic process (GO:0019377)2.54425247
87glycine transport (GO:0015816)2.54126716
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.53645949
89cortical actin cytoskeleton organization (GO:0030866)2.52648421
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52552104
91potassium ion homeostasis (GO:0055075)2.52502133
92striated muscle contraction (GO:0006941)2.52305184
93membrane repolarization (GO:0086009)2.52124802
94regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52004514
95positive regulation of cation channel activity (GO:2001259)2.51881307
96glutamate secretion (GO:0014047)2.50918322
97response to thyroid hormone (GO:0097066)2.50282700
98vocalization behavior (GO:0071625)2.49782174
99positive regulation of receptor recycling (GO:0001921)2.49729975
100positive regulation of sodium ion transport (GO:0010765)2.49652799
101positive regulation of Rap GTPase activity (GO:0032854)2.49560731
102modulation by symbiont of host cellular process (GO:0044068)2.49377672
103regulation of cardiac muscle cell contraction (GO:0086004)2.49225025
104cellular sodium ion homeostasis (GO:0006883)2.49128556
105regulation of relaxation of muscle (GO:1901077)2.48047418
106positive regulation of cellular amide metabolic process (GO:0034250)2.47943235
107protein localization to endosome (GO:0036010)2.47392401
108cardiac conduction (GO:0061337)2.47286789
109regulation of cell communication by electrical coupling (GO:0010649)2.46184369
110neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.46139421
111regulation of vitamin D biosynthetic process (GO:0060556)2.46043596
112adhesion of symbiont to host (GO:0044406)2.45726758
113actomyosin structure organization (GO:0031032)2.45368467
114neuromuscular process controlling balance (GO:0050885)2.45166021
115negative regulation of potassium ion transport (GO:0043267)2.45154826
116positive regulation of gamma-delta T cell activation (GO:0046645)2.43549361
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43081531
118negative regulation of cell killing (GO:0031342)2.43081531
119amino acid import (GO:0043090)2.42022870
120NIK/NF-kappaB signaling (GO:0038061)2.41546230
121regulation of cation channel activity (GO:2001257)2.40502889
122proline transport (GO:0015824)2.40191368
123alanine transport (GO:0032328)2.39782556
124amino sugar catabolic process (GO:0046348)2.39565056
125regulation of voltage-gated calcium channel activity (GO:1901385)2.39316016
126muscle hypertrophy (GO:0014896)2.38473075
127regulation of synaptic vesicle exocytosis (GO:2000300)2.37345698
128neurotransmitter secretion (GO:0007269)2.36848939
129membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.35590706
130regulation of striated muscle contraction (GO:0006942)2.35577731
131establishment of nucleus localization (GO:0040023)2.35497939
132regulation of sodium ion transport (GO:0002028)2.34921066
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34286851
134carnitine shuttle (GO:0006853)2.34196793
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33959619
136regulation of regulated secretory pathway (GO:1903305)2.33121165
137cAMP biosynthetic process (GO:0006171)2.32887362
138regulation of mast cell degranulation (GO:0043304)2.31744145
139oligosaccharide catabolic process (GO:0009313)2.31657789
140adherens junction assembly (GO:0034333)2.31514081
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31035307
142apoptotic cell clearance (GO:0043277)2.30762243
143negative regulation of cell size (GO:0045792)2.29967172
144regulation of NFAT protein import into nucleus (GO:0051532)2.27752561
145vesicle transport along microtubule (GO:0047496)2.27705320
146nerve growth factor signaling pathway (GO:0038180)2.27552618
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.27378947
148neuronal action potential propagation (GO:0019227)2.26355529
149cardiac muscle adaptation (GO:0014887)2.26281009
150cardiac muscle hypertrophy in response to stress (GO:0014898)2.26281009
151muscle hypertrophy in response to stress (GO:0003299)2.26281009
152regulation of synaptic vesicle transport (GO:1902803)2.26023919
153regulation of cholesterol storage (GO:0010885)2.25877806
154positive regulation of extracellular matrix organization (GO:1903055)2.25308850
155regulation of ion transmembrane transporter activity (GO:0032412)2.24426768
156positive regulation of macrophage cytokine production (GO:0060907)2.23494246
157positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23386862
158regulation of clathrin-mediated endocytosis (GO:2000369)2.23172678
159regulation of macrophage cytokine production (GO:0010935)2.21894832
160neutrophil activation involved in immune response (GO:0002283)2.21185468
161cortical cytoskeleton organization (GO:0030865)2.19990610
162myeloid dendritic cell differentiation (GO:0043011)2.19919978
163cell-substrate adherens junction assembly (GO:0007045)2.19112978
164focal adhesion assembly (GO:0048041)2.19112978
165detection of molecule of bacterial origin (GO:0032490)2.14090576
166regulation of type 2 immune response (GO:0002828)2.13231043
167positive regulation of cholesterol efflux (GO:0010875)2.13208370
168response to acidic pH (GO:0010447)2.12724403
169response to manganese ion (GO:0010042)2.11292053
170positive regulation of chemokine biosynthetic process (GO:0045080)2.11021151
171positive regulation of neurotransmitter secretion (GO:0001956)2.10832879
172detection of other organism (GO:0098543)2.10189864
173positive regulation of myotube differentiation (GO:0010831)2.09460956
174negative regulation of cytokine production involved in immune response (GO:0002719)2.09458458
175regulation of macrophage chemotaxis (GO:0010758)2.07275371
176cell volume homeostasis (GO:0006884)2.07030577
177regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.06864671
178activation of JUN kinase activity (GO:0007257)2.06833356
179positive regulation of type 2 immune response (GO:0002830)2.06660855
180ceramide catabolic process (GO:0046514)2.06402345
181regulation of mononuclear cell migration (GO:0071675)2.05818264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.00877460
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65033270
3VDR_21846776_ChIP-Seq_THP-1_Human2.49843452
4DROSHA_22980978_ChIP-Seq_HELA_Human2.35945311
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.28577095
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.28274786
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18861771
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13703704
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10628604
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03610610
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.01259047
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.00505976
13MYC_22102868_ChIP-Seq_BL_Human1.92242044
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86195342
15VDR_24763502_ChIP-Seq_THP-1_Human1.81226107
16KDM2B_26808549_Chip-Seq_K562_Human1.75553349
17KDM2B_26808549_Chip-Seq_DND41_Human1.74170567
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73810651
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72248029
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70475099
21LXR_22292898_ChIP-Seq_THP-1_Human1.65375248
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.63660424
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61712265
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60556027
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60449836
26GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60137340
27* TBX20_22080862_ChIP-Seq_HEART_Mouse1.57786705
28* TBX20_22328084_ChIP-Seq_HEART_Mouse1.57786705
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56398630
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55732922
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.54644014
32* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52588674
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52375263
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52375263
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.51805452
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50599183
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50513352
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50455875
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49484311
40* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48075540
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47907809
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47768645
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46080634
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44001291
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43094650
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42534182
47* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42018535
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40583846
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38174787
50CLOCK_20551151_ChIP-Seq_293T_Human1.38009764
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37836565
52* SPI1_23127762_ChIP-Seq_K562_Human1.36147606
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.35086605
54* MAF_26560356_Chip-Seq_TH1_Human1.34842892
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34780018
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34088125
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32815377
58* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32767531
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.32052350
60REST_21632747_ChIP-Seq_MESCs_Mouse1.28002310
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27772449
62TCF7_22412390_ChIP-Seq_EML_Mouse1.27750669
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26546291
64P68_20966046_ChIP-Seq_HELA_Human1.26536582
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26361322
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24654619
67* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24374695
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24256668
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23872167
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23734292
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23353021
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.23284241
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23037778
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22843899
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.20653295
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16728552
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.16344665
78ZNF263_19887448_ChIP-Seq_K562_Human1.16240762
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16189988
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16178232
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.15800001
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.14738634
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.13891767
84* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13821276
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.13543995
86* MAF_26560356_Chip-Seq_TH2_Human1.13290979
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.12454369
88GATA1_19941826_ChIP-Seq_K562_Human1.12398315
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11598421
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11489583
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10944303
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10810071
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.09144534
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07690805
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07576075
96UTX_26944678_Chip-Seq_JUKART_Human1.07572900
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.07313690
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07253060
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06545349
100* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06343279
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05799482
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05168401
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04964048
104RACK7_27058665_Chip-Seq_MCF-7_Human1.04828781
105* SMC4_20622854_ChIP-Seq_HELA_Human1.03875082
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03420461
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02219606
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02082731
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01953364
110BCOR_27268052_Chip-Seq_Bcells_Human1.01862808
111NCOR1_26117541_ChIP-Seq_K562_Human1.01717226
112SCL_19346495_ChIP-Seq_HPC-7_Human1.01647400
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01365126
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01269620
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00681029
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00338152
117VDR_24787735_ChIP-Seq_THP-1_Human0.99819293
118* IRF8_27001747_Chip-Seq_BMDM_Mouse0.98629446
119* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97975968
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97114537
121* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96153054
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96010312
123AHR_22903824_ChIP-Seq_MCF-7_Human0.95789299
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95052584
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95002309
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.93179785
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92647397
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92252084
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91855615
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91727999
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91381006
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91373947
133CREB1_26743006_Chip-Seq_LNCaP_Human0.91274151
134* CTCF_27219007_Chip-Seq_Bcells_Human0.90346242
135KLF4_19829295_ChIP-Seq_ESCs_Human0.90295744
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90278069
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89885996
138* TP63_22573176_ChIP-Seq_HFKS_Human0.88705829
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.87934361
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.87635804
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.87474908
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86968273
143* MITF_21258399_ChIP-Seq_MELANOMA_Human0.84958671
144AR_19668381_ChIP-Seq_PC3_Human0.84823667
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.83225715
146GATA2_19941826_ChIP-Seq_K562_Human0.83181234
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.82843876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17669612
2MP0000751_myopathy3.74645802
3MP0002837_dystrophic_cardiac_calcinosis3.71470614
4MP0003646_muscle_fatigue3.52403096
5MP0004510_myositis3.38243646
6MP0004084_abnormal_cardiac_muscle3.21742761
7MP0003436_decreased_susceptibility_to2.73456365
8MP0005451_abnormal_body_composition2.71280206
9MP0000569_abnormal_digit_pigmentation2.63731686
10MP0004215_abnormal_myocardial_fiber2.63138226
11MP0004036_abnormal_muscle_relaxation2.46191972
12MP0004130_abnormal_muscle_cell2.38158464
13MP0005058_abnormal_lysosome_morphology2.23953618
14MP0004087_abnormal_muscle_fiber2.09362827
15MP0000749_muscle_degeneration2.09191486
16MP0006082_CNS_inflammation2.08567727
17MP0003635_abnormal_synaptic_transmissio2.08347844
18MP0003172_abnormal_lysosome_physiology1.99058081
19MP0005330_cardiomyopathy1.98586191
20MP0004858_abnormal_nervous_system1.95139084
21MP0009046_muscle_twitch1.95086069
22MP0008260_abnormal_autophagy1.92347824
23MP0002909_abnormal_adrenal_gland1.89900499
24MP0008438_abnormal_cutaneous_collagen1.85777857
25MP0002822_catalepsy1.84663996
26MP0002972_abnormal_cardiac_muscle1.82413508
27MP0003705_abnormal_hypodermis_morpholog1.82160636
28MP0002998_abnormal_bone_remodeling1.80103494
29MP0002419_abnormal_innate_immunity1.80034081
30MP0003453_abnormal_keratinocyte_physiol1.79905054
31MP0004947_skin_inflammation1.76355321
32MP0008775_abnormal_heart_ventricle1.73806348
33MP0003303_peritoneal_inflammation1.71141623
34MP0002148_abnormal_hypersensitivity_rea1.66505241
35MP0000747_muscle_weakness1.65981338
36MP0005167_abnormal_blood-brain_barrier1.64916871
37MP0002064_seizures1.64609998
38MP0004484_altered_response_of1.63057275
39MP0003137_abnormal_impulse_conducting1.61917453
40MP0001849_ear_inflammation1.61494711
41MP0001533_abnormal_skeleton_physiology1.60451029
42MP0008961_abnormal_basal_metabolism1.60022582
43MP0005000_abnormal_immune_tolerance1.59931832
44MP0003690_abnormal_glial_cell1.56959921
45MP0000750_abnormal_muscle_regeneration1.54942732
46MP0010630_abnormal_cardiac_muscle1.53801176
47MP0003329_amyloid_beta_deposits1.53320863
48MP0005620_abnormal_muscle_contractility1.53317249
49MP0002106_abnormal_muscle_physiology1.52950295
50MP0002269_muscular_atrophy1.52847058
51MP0005385_cardiovascular_system_phenoty1.51460178
52MP0001544_abnormal_cardiovascular_syste1.51460178
53MP0008569_lethality_at_weaning1.50674589
54MP0003075_altered_response_to1.50662763
55MP0004270_analgesia1.50356112
56MP0003724_increased_susceptibility_to1.49205719
57MP0005025_abnormal_response_to1.47767515
58MP0009745_abnormal_behavioral_response1.46893518
59MP0005623_abnormal_meninges_morphology1.44282099
60MP0004085_abnormal_heartbeat1.43573489
61MP0009780_abnormal_chondrocyte_physiolo1.41225539
62MP0002063_abnormal_learning/memory/cond1.41053078
63MP0004145_abnormal_muscle_electrophysio1.40688974
64MP0006138_congestive_heart_failure1.39231716
65MP0001790_abnormal_immune_system1.39014091
66MP0005387_immune_system_phenotype1.39014091
67MP0005076_abnormal_cell_differentiation1.38104011
68MP0000604_amyloidosis1.35290851
69MP0009785_altered_susceptibility_to1.29393930
70MP0003300_gastrointestinal_ulcer1.28656161
71MP0001835_abnormal_antigen_presentation1.26209866
72MP0000759_abnormal_skeletal_muscle1.24824088
73MP0003045_fibrosis1.24280382
74MP0005666_abnormal_adipose_tissue1.23922330
75MP0004233_abnormal_muscle_weight1.22819778
76MP0003633_abnormal_nervous_system1.21766800
77MP0005670_abnormal_white_adipose1.20985605
78MP0000685_abnormal_immune_system1.19835142
79MP0005369_muscle_phenotype1.18877410
80MP0008004_abnormal_stomach_pH1.18014162
81MP0009840_abnormal_foam_cell1.17463214
82MP0000858_altered_metastatic_potential1.17322410
83MP0003448_altered_tumor_morphology1.15912850
84MP0001853_heart_inflammation1.14739324
85MP0001958_emphysema1.14002574
86MP0001545_abnormal_hematopoietic_system1.13786613
87MP0005397_hematopoietic_system_phenotyp1.13786613
88MP0002452_abnormal_antigen_presenting1.12366489
89MP0005464_abnormal_platelet_physiology1.11858867
90MP0002723_abnormal_immune_serum1.08991683
91MP0005257_abnormal_intraocular_pressure1.06426617
92MP0005375_adipose_tissue_phenotype1.06292796
93MP0005023_abnormal_wound_healing1.05309333
94MP0005409_darkened_coat_color1.05249138
95MP0001501_abnormal_sleep_pattern1.04673225
96MP0003566_abnormal_cell_adhesion1.04522242
97MP0003828_pulmonary_edema1.03973199
98MP0004185_abnormal_adipocyte_glucose1.03762262
99MP0003880_abnormal_central_pattern1.01553577
100MP0002272_abnormal_nervous_system0.99458404
101MP0002420_abnormal_adaptive_immunity0.98799026
102MP0001819_abnormal_immune_cell0.97797408
103MP0002090_abnormal_vision0.96990301
104MP0001440_abnormal_grooming_behavior0.95348825
105MP0002572_abnormal_emotion/affect_behav0.95195027
106MP0003191_abnormal_cellular_cholesterol0.93596224
107MP0005165_increased_susceptibility_to0.93005731
108MP0005535_abnormal_body_temperature0.90537895
109MP0002254_reproductive_system_inflammat0.90374717
110MP0001800_abnormal_humoral_immune0.90302842
111MP0005390_skeleton_phenotype0.90007998
112MP0001968_abnormal_touch/_nociception0.89531273
113MP0004811_abnormal_neuron_physiology0.89264698
114MP0000013_abnormal_adipose_tissue0.89234510
115MP0001486_abnormal_startle_reflex0.89119398
116MP0003634_abnormal_glial_cell0.87655005
117MP0000767_abnormal_smooth_muscle0.85818763
118MP0009333_abnormal_splenocyte_physiolog0.85728518
119MP0008874_decreased_physiological_sensi0.85130647
120MP0005423_abnormal_somatic_nervous0.83720448
121MP0003879_abnormal_hair_cell0.83375940
122MP0001845_abnormal_inflammatory_respons0.83265351
123MP0003091_abnormal_cell_migration0.82520668
124MP0002332_abnormal_exercise_endurance0.82442125
125MP0005671_abnormal_response_to0.82055690
126MP0002405_respiratory_system_inflammati0.81619423
127MP0002877_abnormal_melanocyte_morpholog0.81477562
128MP0003631_nervous_system_phenotype0.80908886
129MP0010155_abnormal_intestine_physiology0.80439650
130MP0003656_abnormal_erythrocyte_physiolo0.79853326
131MP0000920_abnormal_myelination0.79656684
132MP0000003_abnormal_adipose_tissue0.79371048
133MP0009764_decreased_sensitivity_to0.79085169
134MP0005386_behavior/neurological_phenoty0.78806441
135MP0004924_abnormal_behavior0.78806441
136MP0001851_eye_inflammation0.78717585
137MP0000343_altered_response_to0.77975763
138MP0003183_abnormal_peptide_metabolism0.76717259
139MP0008469_abnormal_protein_level0.76633510
140MP0002734_abnormal_mechanical_nocicepti0.76478494
141MP0001348_abnormal_lacrimal_gland0.76428824
142MP0002896_abnormal_bone_mineralization0.76073135
143MP0002933_joint_inflammation0.75744685
144MP0002067_abnormal_sensory_capabilities0.75682970
145MP0005166_decreased_susceptibility_to0.74138543
146MP0004885_abnormal_endolymph0.73544883
147MP0003221_abnormal_cardiomyocyte_apopto0.73309352
148MP0001970_abnormal_pain_threshold0.72963148
149MP0005410_abnormal_fertilization0.71059333
150MP0009278_abnormal_bone_marrow0.70714771
151MP0000371_diluted_coat_color0.70397191
152MP0003279_aneurysm0.68786735
153MP0000733_abnormal_muscle_development0.66887201

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.89155924
2Bundle branch block (HP:0011710)4.31167474
3Asymmetric septal hypertrophy (HP:0001670)3.81258360
4Exercise-induced myalgia (HP:0003738)3.78856930
5Ventricular fibrillation (HP:0001663)3.68054750
6Exercise-induced muscle cramps (HP:0003710)3.59536242
7Atrial fibrillation (HP:0005110)3.55172812
8Hyporeflexia of lower limbs (HP:0002600)3.51695997
9Primary atrial arrhythmia (HP:0001692)3.36543020
10Muscle fiber splitting (HP:0003555)3.31866573
11Calf muscle hypertrophy (HP:0008981)3.30936782
12Ventricular tachycardia (HP:0004756)3.29962411
13Difficulty running (HP:0009046)3.21978334
14Supranuclear gaze palsy (HP:0000605)3.19993836
15Syncope (HP:0001279)3.17648021
16Heart block (HP:0012722)3.17108885
17Supraventricular tachycardia (HP:0004755)3.14057220
18Myokymia (HP:0002411)3.11208875
19Supraventricular arrhythmia (HP:0005115)3.09210107
20Atrioventricular block (HP:0001678)3.05823117
21Obstructive sleep apnea (HP:0002870)3.01894204
22Abnormal atrioventricular conduction (HP:0005150)3.01554606
23Prolonged QT interval (HP:0001657)3.01425593
24Abnormality of the calf musculature (HP:0001430)3.00579877
25Muscle hypertrophy of the lower extremities (HP:0008968)2.90588323
26Ventricular arrhythmia (HP:0004308)2.87912525
27Dysmetric saccades (HP:0000641)2.87485645
28Nuclear cataract (HP:0100018)2.84940026
29Myoglobinuria (HP:0002913)2.78068591
30Subaortic stenosis (HP:0001682)2.77460358
31Abnormality of the left ventricular outflow tract (HP:0011103)2.77460358
32Increased connective tissue (HP:0009025)2.75636381
33Abnormality of macrophages (HP:0004311)2.67766457
34Increased cerebral lipofuscin (HP:0011813)2.67400265
35Visual hallucinations (HP:0002367)2.66558493
36Systemic lupus erythematosus (HP:0002725)2.65298969
37Apathy (HP:0000741)2.62540673
38Upper limb amyotrophy (HP:0009129)2.61601672
39Distal upper limb amyotrophy (HP:0007149)2.61601672
40Cerebral aneurysm (HP:0004944)2.61553368
41Lower limb amyotrophy (HP:0007210)2.61366414
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60474455
43Abnormality of polysaccharide metabolism (HP:0011012)2.60474455
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60474455
45Eczematoid dermatitis (HP:0000976)2.59346296
46Focal motor seizures (HP:0011153)2.58162751
47EMG: myopathic abnormalities (HP:0003458)2.57395167
48Difficulty climbing stairs (HP:0003551)2.56214070
49Vertebral compression fractures (HP:0002953)2.56174200
50Distal lower limb muscle weakness (HP:0009053)2.54961681
51Right ventricular cardiomyopathy (HP:0011663)2.53837448
52Urinary glycosaminoglycan excretion (HP:0003541)2.52305084
53Mucopolysacchariduria (HP:0008155)2.52305084
54Lipoatrophy (HP:0100578)2.50429868
55Focal seizures (HP:0007359)2.50226818
56Axonal loss (HP:0003447)2.50132659
57Postural instability (HP:0002172)2.48772760
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.48047043
59Protrusio acetabuli (HP:0003179)2.47912178
60Abnormal EKG (HP:0003115)2.46326384
61Diminished motivation (HP:0000745)2.45453366
62Frequent falls (HP:0002359)2.43625077
63Rapidly progressive (HP:0003678)2.41406181
64Distal lower limb amyotrophy (HP:0008944)2.40364869
65Myotonia (HP:0002486)2.38143233
66Action tremor (HP:0002345)2.36844229
67Type 1 muscle fiber predominance (HP:0003803)2.34231195
68Hemiplegia (HP:0002301)2.26286078
69Global brain atrophy (HP:0002283)2.18555102
70Increased variability in muscle fiber diameter (HP:0003557)2.17186066
71Depression (HP:0000716)2.16376111
72Recurrent bacterial skin infections (HP:0005406)2.13613412
73Vacuolated lymphocytes (HP:0001922)2.13103112
74Neuronal loss in central nervous system (HP:0002529)2.11655356
75Loss of speech (HP:0002371)2.08882659
76Recurrent abscess formation (HP:0002722)2.06904096
77Dilated cardiomyopathy (HP:0001644)2.06146994
78Achilles tendon contracture (HP:0001771)2.04033685
79Premature rupture of membranes (HP:0001788)2.03860847
80Abnormality of binocular vision (HP:0011514)2.02950085
81Diplopia (HP:0000651)2.02950085
82Disinhibition (HP:0000734)2.02937259
83Urinary urgency (HP:0000012)2.01541920
84Urinary bladder sphincter dysfunction (HP:0002839)2.01270425
85Amyloidosis (HP:0011034)1.99238483
86Broad metatarsal (HP:0001783)1.98866629
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96384052
88Hand muscle atrophy (HP:0009130)1.95667117
89Ankle clonus (HP:0011448)1.93791801
90Hyperacusis (HP:0010780)1.93439068
91Cellulitis (HP:0100658)1.93163341
92Hamartoma of the eye (HP:0010568)1.92810605
93Impaired vibration sensation in the lower limbs (HP:0002166)1.92087291
94Dementia (HP:0000726)1.91785463
95Abnormal social behavior (HP:0012433)1.91113461
96Impaired social interactions (HP:0000735)1.91113461
97Interstitial pulmonary disease (HP:0006530)1.89134224
98Dysdiadochokinesis (HP:0002075)1.88480813
99Upper motor neuron abnormality (HP:0002127)1.86629615
100Cerebral inclusion bodies (HP:0100314)1.86388730
101Myocardial infarction (HP:0001658)1.86360000
102Dysostosis multiplex (HP:0000943)1.86282114
103Abnormality of the lower motor neuron (HP:0002366)1.85841515
104Abnormality of the Achilles tendon (HP:0005109)1.85769407
105Abnormality of the periventricular white matter (HP:0002518)1.84546596
106Abnormality of skeletal muscle fiber size (HP:0012084)1.83926565
107Spinal rigidity (HP:0003306)1.83926010
108Slow saccadic eye movements (HP:0000514)1.83015874
109Scapular winging (HP:0003691)1.82888401
110Polygenic inheritance (HP:0010982)1.82090110
111Peripheral hypomyelination (HP:0007182)1.82065855
112Neurofibrillary tangles (HP:0002185)1.81622908
113Annular pancreas (HP:0001734)1.81477269
114EMG: neuropathic changes (HP:0003445)1.81417609
115Foot dorsiflexor weakness (HP:0009027)1.81137952
116Resting tremor (HP:0002322)1.81080912
117Myopathic facies (HP:0002058)1.80662106
118Segmental peripheral demyelination/remyelination (HP:0003481)1.78695493
119Thin bony cortex (HP:0002753)1.78681743
120Long toe (HP:0010511)1.78307869
121Limb-girdle muscle atrophy (HP:0003797)1.78040425
122Insomnia (HP:0100785)1.77877262
123Dysmetria (HP:0001310)1.77418837
124Mutism (HP:0002300)1.77146063
125Sudden cardiac death (HP:0001645)1.76992057
126Palpitations (HP:0001962)1.76456607
127Abnormality of the foot musculature (HP:0001436)1.75302944
128Abnormality of liposaccharide metabolism (HP:0010968)1.74060435
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.74060435
130Abnormality of glycolipid metabolism (HP:0010969)1.74060435
131Spontaneous hematomas (HP:0007420)1.69592743
132Aneurysm (HP:0002617)1.69352237
133Increased IgE level (HP:0003212)1.69123749
134Spondylolisthesis (HP:0003302)1.68972727
135Facial diplegia (HP:0001349)1.68637551
136Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.68382668
137Bulbar palsy (HP:0001283)1.67842965
138Purpura (HP:0000979)1.67698443
139Abnormality of vision evoked potentials (HP:0000649)1.67437168
140Pointed chin (HP:0000307)1.67414955
141Lymphangioma (HP:0100764)1.66791178
142Generalized tonic-clonic seizures (HP:0002069)1.66523676
143Dilatation of the ascending aorta (HP:0005111)1.66254432
144Thoracic kyphosis (HP:0002942)1.66179398
145Poor eye contact (HP:0000817)1.66141747
146Hypercortisolism (HP:0001578)1.65114178
147Cervical subluxation (HP:0003308)1.64961299
148Mediastinal lymphadenopathy (HP:0100721)1.64637091
149Abnormality of saccadic eye movements (HP:0000570)1.64246885
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.64158073
151Mitral regurgitation (HP:0001653)1.63834649
152Gingivitis (HP:0000230)1.63015302
153Polycythemia (HP:0001901)1.62890849
154Emphysema (HP:0002097)1.61940892
155Mildly elevated creatine phosphokinase (HP:0008180)1.61824999
156J-shaped sella turcica (HP:0002680)1.60541482
157Rigidity (HP:0002063)1.60201663
158Genu recurvatum (HP:0002816)1.59054115
159Orchitis (HP:0100796)1.58518490
160Round ear (HP:0100830)1.58481471
161Muscle fiber inclusion bodies (HP:0100299)1.58374593
162Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.57785250
163Hyperparathyroidism (HP:0000843)1.57694395
164Slender build (HP:0001533)1.57120797
165Abnormality of the thoracic spine (HP:0100711)1.56571898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.96134964
2TRIB33.65265355
3TTN3.17517726
4IRAK32.97998736
5PRKD32.73594972
6LMTK22.47106619
7MAP3K92.46965041
8PKN22.45398545
9RIPK12.13794606
10RIPK42.13019109
11PHKG22.07974416
12PHKG12.07974416
13KSR22.04233885
14CAMKK12.02429486
15TAOK22.00732078
16PAK61.98981822
17DMPK1.97137918
18MAP2K31.92506416
19DAPK21.92123491
20STK381.89873526
21EPHA41.85478291
22NTRK31.67564743
23SMG11.66805644
24MAP3K111.59282372
25CAMK1G1.58814007
26PDK31.57355659
27PDK41.57355659
28NME21.51380230
29MAP3K31.49431160
30ARAF1.49033559
31MAP3K131.48402150
32SIK21.42526345
33ICK1.35129237
34MOS1.33217351
35PINK11.30052570
36EEF2K1.29321418
37MAP3K141.29053314
38CAMK1D1.28147363
39TAOK11.27680148
40BLK1.26344463
41LATS21.24974105
42PRKCH1.23763013
43NTRK11.19127070
44WNK11.17198469
45BMX1.13836878
46MAP4K11.11679175
47JAK11.10063228
48MAP3K71.09062456
49EPHB11.08733519
50PDPK11.08038547
51RET1.07037837
52IRAK21.06220577
53ZAP701.05454513
54PDGFRA1.05223745
55FES1.05001532
56CAMKK21.04335733
57PTK61.03692895
58PDK11.02433472
59TYRO31.01352309
60ERN11.01206183
61ALK1.01110235
62PAK30.99670220
63SGK30.99433448
64TESK10.98513530
65PRKD20.98427920
66MINK10.97217403
67PDK20.96777186
68PTK2B0.96605507
69IRAK40.95767304
70MAP3K40.92843365
71PRKD10.91650956
72TBK10.91200609
73CDK120.89233443
74MAP3K10.88032237
75CDC42BPA0.87589733
76NEK10.86410157
77CSK0.84031079
78CDK50.81116330
79FGR0.79460424
80CAMK10.78313114
81NTRK20.77372586
82TNK20.75178408
83MAP3K20.75126847
84CAMK40.75062767
85OBSCN0.72665967
86MAP2K40.72606628
87JAK30.72356595
88STK110.70646647
89GRK70.69050269
90WNK40.68541571
91BRAF0.67652141
92DAPK30.67404005
93MAPK70.66801102
94ABL20.65856108
95JAK20.63695104
96MAPK120.61778327
97SGK10.61765929
98MAP3K60.61563596
99MAPK40.61356836
100HIPK20.60809462
101MARK20.60573971
102SIK10.59875612
103RPS6KC10.59873054
104RPS6KL10.59873054
105MTOR0.56646906
106PAK40.56295802
107TYK20.55590194
108PIM20.55486122
109PDGFRB0.55087713
110PRKG20.54680288
111MATK0.54665705
112SIK30.54080393
113PRKAA10.53298040
114ROCK10.52846956
115HCK0.52323431
116DDR20.51396639
117MYLK0.51275166
118BMPR20.49490873
119SGK2230.49468877
120SGK4940.49468877
121CAMK2D0.48808315
122SGK20.47826679
123PRKAA20.46217806
124IKBKE0.45820012
125KSR10.45136971
126MUSK0.44612101
127SCYL20.44189797
128FYN0.44141276
129MAP2K60.43889215
130TGFBR20.43624199
131PKN10.43494034
132RPS6KA30.42847853
133MST1R0.41883336
134FGFR40.41762828
135IKBKB0.41753458
136FGFR30.41606310
137MARK30.40345577
138MAPK100.39869275
139RPS6KA20.39736097
140MAPK110.39693046
141GRK50.39570920
142CDK150.39349529
143KIT0.38047352
144PTK20.37617124
145UHMK10.37350129
146LRRK20.36830498
147MARK10.36783195
148DAPK10.36650347

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.90820713
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04564345
3Nitrogen metabolism_Homo sapiens_hsa009102.02704218
4Dilated cardiomyopathy_Homo sapiens_hsa054141.98017486
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95761792
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83436743
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76818334
8Synaptic vesicle cycle_Homo sapiens_hsa047211.72007711
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63266021
10Olfactory transduction_Homo sapiens_hsa047401.62853880
11Prion diseases_Homo sapiens_hsa050201.58841406
12Type II diabetes mellitus_Homo sapiens_hsa049301.57814135
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57677234
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55914428
15Leishmaniasis_Homo sapiens_hsa051401.54937323
16Gastric acid secretion_Homo sapiens_hsa049711.52831168
17Circadian entrainment_Homo sapiens_hsa047131.47001360
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46585070
19Cardiac muscle contraction_Homo sapiens_hsa042601.44649302
20Acute myeloid leukemia_Homo sapiens_hsa052211.40723371
21Long-term potentiation_Homo sapiens_hsa047201.39883552
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38938352
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36853800
24Salivary secretion_Homo sapiens_hsa049701.34962611
25TNF signaling pathway_Homo sapiens_hsa046681.34280595
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32332921
27Insulin secretion_Homo sapiens_hsa049111.29570798
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29289199
29Malaria_Homo sapiens_hsa051441.26975024
30Morphine addiction_Homo sapiens_hsa050321.22947615
31Pertussis_Homo sapiens_hsa051331.22803476
32Oxytocin signaling pathway_Homo sapiens_hsa049211.22505628
33Glutamatergic synapse_Homo sapiens_hsa047241.22441346
34GABAergic synapse_Homo sapiens_hsa047271.22358763
35Staphylococcus aureus infection_Homo sapiens_hsa051501.18494736
36Renin secretion_Homo sapiens_hsa049241.17558571
37Cholinergic synapse_Homo sapiens_hsa047251.17089707
38Toxoplasmosis_Homo sapiens_hsa051451.16736744
39Dorso-ventral axis formation_Homo sapiens_hsa043201.15788756
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15510988
41Bladder cancer_Homo sapiens_hsa052191.13174263
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.11308500
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09901685
44Calcium signaling pathway_Homo sapiens_hsa040201.09415914
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.07321189
46GnRH signaling pathway_Homo sapiens_hsa049121.06537388
47Rheumatoid arthritis_Homo sapiens_hsa053231.06502898
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06501846
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06404494
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05807669
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04528872
52cAMP signaling pathway_Homo sapiens_hsa040241.03467525
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03309638
54Glioma_Homo sapiens_hsa052141.01864349
55Amphetamine addiction_Homo sapiens_hsa050311.01210425
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00955708
57* Salmonella infection_Homo sapiens_hsa051321.00815060
58Estrogen signaling pathway_Homo sapiens_hsa049151.00604888
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.97991533
60Notch signaling pathway_Homo sapiens_hsa043300.97192178
61Insulin resistance_Homo sapiens_hsa049310.97125780
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96599691
63Osteoclast differentiation_Homo sapiens_hsa043800.95055745
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94457431
65VEGF signaling pathway_Homo sapiens_hsa043700.93344231
66Influenza A_Homo sapiens_hsa051640.93198888
67Dopaminergic synapse_Homo sapiens_hsa047280.92683487
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.92257538
69Phagosome_Homo sapiens_hsa041450.91654106
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91091918
71Lysosome_Homo sapiens_hsa041420.90736039
72Hepatitis C_Homo sapiens_hsa051600.89563692
73Nicotine addiction_Homo sapiens_hsa050330.89011793
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.88500633
75mTOR signaling pathway_Homo sapiens_hsa041500.86660331
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86049449
77Pancreatic cancer_Homo sapiens_hsa052120.85672941
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85413108
79Insulin signaling pathway_Homo sapiens_hsa049100.85117211
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84863984
81Glucagon signaling pathway_Homo sapiens_hsa049220.84802415
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.84625553
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.83815086
84Prolactin signaling pathway_Homo sapiens_hsa049170.83364612
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83103275
86Hepatitis B_Homo sapiens_hsa051610.82514138
87Bile secretion_Homo sapiens_hsa049760.82362874
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81575279
89Fatty acid biosynthesis_Homo sapiens_hsa000610.80939313
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.77135243
91Gap junction_Homo sapiens_hsa045400.76462075
92Vibrio cholerae infection_Homo sapiens_hsa051100.74968712
93Shigellosis_Homo sapiens_hsa051310.74904509
94Endometrial cancer_Homo sapiens_hsa052130.74686941
95Fatty acid degradation_Homo sapiens_hsa000710.74583306
96B cell receptor signaling pathway_Homo sapiens_hsa046620.74502068
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74365294
98T cell receptor signaling pathway_Homo sapiens_hsa046600.73667609
99African trypanosomiasis_Homo sapiens_hsa051430.72721817
100Apoptosis_Homo sapiens_hsa042100.72550056
101Legionellosis_Homo sapiens_hsa051340.71969106
102Endocytosis_Homo sapiens_hsa041440.70466006
103Collecting duct acid secretion_Homo sapiens_hsa049660.69768852
104Arginine biosynthesis_Homo sapiens_hsa002200.69564166
105Pancreatic secretion_Homo sapiens_hsa049720.69090007
106Cocaine addiction_Homo sapiens_hsa050300.68936757
107Viral myocarditis_Homo sapiens_hsa054160.67087643
108Focal adhesion_Homo sapiens_hsa045100.66743015
109Renal cell carcinoma_Homo sapiens_hsa052110.66466711
110Amoebiasis_Homo sapiens_hsa051460.66285408
111Fatty acid metabolism_Homo sapiens_hsa012120.65633389
112HIF-1 signaling pathway_Homo sapiens_hsa040660.65208285
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.64949294
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64655195
115Chemokine signaling pathway_Homo sapiens_hsa040620.64481082
116PPAR signaling pathway_Homo sapiens_hsa033200.64224698
117Tuberculosis_Homo sapiens_hsa051520.63505743
118ErbB signaling pathway_Homo sapiens_hsa040120.62923294
119Allograft rejection_Homo sapiens_hsa053300.62789036
120Inositol phosphate metabolism_Homo sapiens_hsa005620.62445064
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61874609
122Non-small cell lung cancer_Homo sapiens_hsa052230.60913561
123Propanoate metabolism_Homo sapiens_hsa006400.60289148
124Proteoglycans in cancer_Homo sapiens_hsa052050.60047506
125Chronic myeloid leukemia_Homo sapiens_hsa052200.59949480
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59347984
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59095131
128Platelet activation_Homo sapiens_hsa046110.58669624
129MAPK signaling pathway_Homo sapiens_hsa040100.58294556
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58150259
131Taste transduction_Homo sapiens_hsa047420.57451615
132Melanogenesis_Homo sapiens_hsa049160.56801595
133Long-term depression_Homo sapiens_hsa047300.55505245
134Thyroid hormone synthesis_Homo sapiens_hsa049180.54108466
135AMPK signaling pathway_Homo sapiens_hsa041520.53868969
136Measles_Homo sapiens_hsa051620.53843556
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52804744
138Rap1 signaling pathway_Homo sapiens_hsa040150.52698806
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52522894
140Fructose and mannose metabolism_Homo sapiens_hsa000510.52138188
141Galactose metabolism_Homo sapiens_hsa000520.51785272
142Choline metabolism in cancer_Homo sapiens_hsa052310.51752951

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