PLEKHM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.66591575
2modulation by symbiont of host immune response (GO:0052553)5.66591575
3positive regulation by symbiont of host defense response (GO:0052509)5.66591575
4modulation by symbiont of host defense response (GO:0052031)5.66591575
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.66591575
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.66591575
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.67598771
8macrophage activation involved in immune response (GO:0002281)4.35337932
9regulation of B cell receptor signaling pathway (GO:0050855)4.23479063
10microglial cell activation (GO:0001774)4.02347926
11regulation of interferon-beta biosynthetic process (GO:0045357)3.99655548
12neuronal action potential propagation (GO:0019227)3.94789558
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93249808
14response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86093475
15response to host immune response (GO:0052572)3.86093475
16gamma-aminobutyric acid transport (GO:0015812)3.82092562
17neutrophil activation involved in immune response (GO:0002283)3.77984222
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.61136013
19positive regulation of cellular amide metabolic process (GO:0034250)3.47986015
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.47411942
21response to host (GO:0075136)3.47411942
22response to host defenses (GO:0052200)3.47411942
23response to peptidoglycan (GO:0032494)3.33400862
24negative regulation of cell killing (GO:0031342)3.31160765
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31160765
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30406478
27cerebellar Purkinje cell differentiation (GO:0021702)3.13885659
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12108189
29macrophage activation (GO:0042116)3.11749229
30myeloid cell activation involved in immune response (GO:0002275)3.10712641
31I-kappaB phosphorylation (GO:0007252)3.06300218
32positive regulation of antigen processing and presentation (GO:0002579)3.05935811
33glutamate secretion (GO:0014047)3.04993569
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01752680
35B cell receptor signaling pathway (GO:0050853)3.00365086
36positive regulation of gamma-delta T cell activation (GO:0046645)3.00223436
37germinal center formation (GO:0002467)2.98607380
38neurotransmitter-gated ion channel clustering (GO:0072578)2.97852951
39natural killer cell mediated cytotoxicity (GO:0042267)2.97294429
40natural killer cell mediated immunity (GO:0002228)2.97294429
41synaptic transmission, glutamatergic (GO:0035249)2.96715905
42postsynaptic membrane organization (GO:0001941)2.95839344
43immunoglobulin mediated immune response (GO:0016064)2.93102502
44serotonin metabolic process (GO:0042428)2.92625585
45neuron cell-cell adhesion (GO:0007158)2.90193172
46glutamate receptor signaling pathway (GO:0007215)2.89938841
47L-amino acid import (GO:0043092)2.89297770
48gamma-aminobutyric acid signaling pathway (GO:0007214)2.86680902
49respiratory burst (GO:0045730)2.85331679
50regulation of mast cell degranulation (GO:0043304)2.84253507
51positive regulation of interferon-alpha production (GO:0032727)2.83879911
52response to muramyl dipeptide (GO:0032495)2.82864392
53proline transport (GO:0015824)2.82803157
54neutrophil activation (GO:0042119)2.80588471
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76975303
56granulocyte activation (GO:0036230)2.76739790
57presynaptic membrane assembly (GO:0097105)2.76397539
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76264381
59neuron-neuron synaptic transmission (GO:0007270)2.76101044
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72680985
61presynaptic membrane organization (GO:0097090)2.71727659
62regulation of interferon-alpha production (GO:0032647)2.71653302
63vocalization behavior (GO:0071625)2.70153015
64regulation of platelet aggregation (GO:0090330)2.69649166
65cellular response to ethanol (GO:0071361)2.69267458
66positive regulation of mast cell activation involved in immune response (GO:0033008)2.67994118
67positive regulation of mast cell degranulation (GO:0043306)2.67994118
68neutrophil mediated immunity (GO:0002446)2.67244663
69neurotransmitter secretion (GO:0007269)2.66493587
70primary amino compound metabolic process (GO:1901160)2.66392170
71interferon-gamma-mediated signaling pathway (GO:0060333)2.65981984
72regulation of mast cell activation involved in immune response (GO:0033006)2.65209757
73regulation of mast cell activation (GO:0033003)2.59298690
74potassium ion import (GO:0010107)2.59167773
75adult walking behavior (GO:0007628)2.58846193
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57799132
77neuronal action potential (GO:0019228)2.56860112
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.56623100
79behavioral response to nicotine (GO:0035095)2.55490502
80synaptic vesicle maturation (GO:0016188)2.55338822
81transmission of nerve impulse (GO:0019226)2.55187823
82fucose catabolic process (GO:0019317)2.54938932
83L-fucose metabolic process (GO:0042354)2.54938932
84L-fucose catabolic process (GO:0042355)2.54938932
85G-protein coupled receptor internalization (GO:0002031)2.53486624
86positive regulation of mast cell activation (GO:0033005)2.52630649
87regulation of leukocyte degranulation (GO:0043300)2.51555307
88neuromuscular synaptic transmission (GO:0007274)2.50852535
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50672722
90establishment of protein localization to Golgi (GO:0072600)2.50558428
91startle response (GO:0001964)2.50545012
92phagosome maturation (GO:0090382)2.48720647
93regulation of synaptic vesicle exocytosis (GO:2000300)2.48212590
94regulation of antigen processing and presentation (GO:0002577)2.48172605
95negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47914718
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47769926
97cyclic nucleotide catabolic process (GO:0009214)2.47657860
98neuronal ion channel clustering (GO:0045161)2.47221618
99locomotory exploration behavior (GO:0035641)2.46894976
100regulation of neurotransmitter secretion (GO:0046928)2.46013664
101leukocyte mediated cytotoxicity (GO:0001909)2.45210604
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.45110354
103negative regulation of mast cell activation (GO:0033004)2.44913822
104synaptic vesicle endocytosis (GO:0048488)2.44244015
105regulation of ARF protein signal transduction (GO:0032012)2.43905376
106exploration behavior (GO:0035640)2.43758523
107regulation of regulated secretory pathway (GO:1903305)2.43719128
108nerve growth factor signaling pathway (GO:0038180)2.42656599
109T cell mediated immunity (GO:0002456)2.42485970
110central nervous system myelination (GO:0022010)2.42186110
111axon ensheathment in central nervous system (GO:0032291)2.42186110
112regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42014280
113cAMP catabolic process (GO:0006198)2.41761965
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40438091
115protein localization to synapse (GO:0035418)2.40437361
116regulation of neurotransmitter transport (GO:0051588)2.40117993
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.39489531
118positive regulation of heat generation (GO:0031652)2.39223685
119detection of light stimulus involved in sensory perception (GO:0050962)2.39024187
120detection of light stimulus involved in visual perception (GO:0050908)2.39024187
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.38304003
122positive regulation of macrophage cytokine production (GO:0060907)2.36936164
123mature B cell differentiation (GO:0002335)2.36790972
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36500482
125dendritic spine morphogenesis (GO:0060997)2.36211612
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.35431939
127negative regulation of dendrite development (GO:2000171)2.34998676
128pyrimidine nucleobase catabolic process (GO:0006208)2.34885787
129regulation of glutamate receptor signaling pathway (GO:1900449)2.34600719
130defense response to protozoan (GO:0042832)2.34589114
131membrane depolarization (GO:0051899)2.34527489
132positive regulation of interleukin-12 production (GO:0032735)2.34426759
133activated T cell proliferation (GO:0050798)2.33958292
134regulation of voltage-gated calcium channel activity (GO:1901385)2.33830212
135negative regulation of neurotransmitter transport (GO:0051589)2.33330815
136regulation of postsynaptic membrane potential (GO:0060078)2.32996752
137auditory behavior (GO:0031223)2.32529744
138regulation of B cell differentiation (GO:0045577)2.31348101
139phosphorelay signal transduction system (GO:0000160)2.31224045
140positive regulation of interferon-beta production (GO:0032728)2.31056891
141regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30903615
142negative regulation of dendrite morphogenesis (GO:0050774)2.27890254
143B cell homeostasis (GO:0001782)2.27384393
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.26653960
145neurotransmitter transport (GO:0006836)2.26118038
146cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26015331
147regulation of synaptic vesicle transport (GO:1902803)2.25914804
148cellular potassium ion homeostasis (GO:0030007)2.25797276
149synaptic vesicle exocytosis (GO:0016079)2.25607144
150ionotropic glutamate receptor signaling pathway (GO:0035235)2.25536772
151negative regulation of interleukin-17 production (GO:0032700)2.25223037
152central nervous system projection neuron axonogenesis (GO:0021952)2.24494565
153regulation of sarcomere organization (GO:0060297)2.24217461
154regulation of dendritic spine development (GO:0060998)2.23393028
155vesicle transport along microtubule (GO:0047496)2.23299806
156indole-containing compound metabolic process (GO:0042430)2.23176906
157amino acid import (GO:0043090)2.22686459
158intracellular pH reduction (GO:0051452)2.22094005
159potassium ion transmembrane transport (GO:0071805)2.21598754
160cellular potassium ion transport (GO:0071804)2.21598754
161protein targeting to Golgi (GO:0000042)2.21394640
162cytoplasmic mRNA processing body assembly (GO:0033962)2.21110312
163myeloid leukocyte activation (GO:0002274)2.20713241
164regulation of germinal center formation (GO:0002634)2.19382538
165positive regulation of toll-like receptor signaling pathway (GO:0034123)2.19089642
166positive regulation of chemokine biosynthetic process (GO:0045080)2.19009110
167regulation of neuronal synaptic plasticity (GO:0048168)2.18998406
168protein K11-linked deubiquitination (GO:0035871)2.18316575
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.17976487
170glycosphingolipid biosynthetic process (GO:0006688)2.17122430
171adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.16612346
172central nervous system neuron axonogenesis (GO:0021955)2.16149424
173regulation of neurotransmitter levels (GO:0001505)2.15792486
174behavioral defense response (GO:0002209)2.15300067
175behavioral fear response (GO:0001662)2.15300067
176interkinetic nuclear migration (GO:0022027)2.15123958
177synapse assembly (GO:0007416)2.15020192
178modulation by symbiont of host cellular process (GO:0044068)2.14975057
179lipid translocation (GO:0034204)2.14832470
180B cell proliferation (GO:0042100)2.14519280
181regulation of cellular amide metabolic process (GO:0034248)2.13974828
182negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.12892197
183positive regulation of B cell differentiation (GO:0045579)2.12558753
184regulation of interleukin-12 biosynthetic process (GO:0045075)2.12152752
185NIK/NF-kappaB signaling (GO:0038061)2.11791543
186membrane depolarization during action potential (GO:0086010)2.11750631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.30800583
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.80056930
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.07013333
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84946943
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.71843999
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.71524721
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.65506313
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63670664
9GBX2_23144817_ChIP-Seq_PC3_Human2.43308094
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37277667
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.36090661
12EZH2_22144423_ChIP-Seq_EOC_Human2.30564746
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07000357
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06971227
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06508336
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02494497
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97810888
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94808046
19SPI1_23127762_ChIP-Seq_K562_Human1.91017243
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84950704
21DROSHA_22980978_ChIP-Seq_HELA_Human1.74985211
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74792118
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69093643
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66585140
25RUNX_20019798_ChIP-Seq_JUKART_Human1.63473923
26* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53586175
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53399701
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52859874
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51393926
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48884675
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45536521
32VDR_24787735_ChIP-Seq_THP-1_Human1.41750433
33AR_21572438_ChIP-Seq_LNCaP_Human1.41546714
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.40642562
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40414212
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39572858
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37435480
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36988408
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35709769
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35709769
41* FLI1_27457419_Chip-Seq_LIVER_Mouse1.35578362
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35493506
43BCAT_22108803_ChIP-Seq_LS180_Human1.35016278
44* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34996887
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33576311
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33320119
47* RARB_27405468_Chip-Seq_BRAIN_Mouse1.32648137
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30990119
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.30426309
50ZNF274_21170338_ChIP-Seq_K562_Hela1.30381905
51REST_21632747_ChIP-Seq_MESCs_Mouse1.30003898
52AHR_22903824_ChIP-Seq_MCF-7_Human1.28857936
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27804390
54* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27190153
55* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27112816
56TP53_16413492_ChIP-PET_HCT116_Human1.26577432
57* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24701010
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24617514
59ER_23166858_ChIP-Seq_MCF-7_Human1.23831682
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22716624
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.20138928
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.19624925
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19390846
64VDR_22108803_ChIP-Seq_LS180_Human1.18890457
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.18540922
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17509536
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17279126
68* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17228404
69* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16686682
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16637910
71* STAT3_23295773_ChIP-Seq_U87_Human1.16208919
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16085481
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.15097677
74CBP_20019798_ChIP-Seq_JUKART_Human1.14977318
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14977318
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14785663
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14742211
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14633767
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14010633
80FUS_26573619_Chip-Seq_HEK293_Human1.13867159
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.13696997
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13319895
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13039705
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13039705
85* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12512751
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12313732
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11777873
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.11696743
89RNF2_27304074_Chip-Seq_NSC_Mouse1.10859587
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09647248
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09178480
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09016585
93IGF1R_20145208_ChIP-Seq_DFB_Human1.08550304
94* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08314936
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08285595
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.08152346
97P300_19829295_ChIP-Seq_ESCs_Human1.07861860
98* PU_27001747_Chip-Seq_BMDM_Mouse1.07831507
99* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07636216
100* KDM2B_26808549_Chip-Seq_REH_Human1.07447280
101* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06997534
102TCF4_22108803_ChIP-Seq_LS180_Human1.06528013
103RXR_22108803_ChIP-Seq_LS180_Human1.06462526
104* AR_25329375_ChIP-Seq_VCAP_Human1.05624310
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.05073854
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.05060071
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03969137
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03419560
109* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02877684
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02649648
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02511915
112* TCF4_23295773_ChIP-Seq_U87_Human1.00799906
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99911462
114* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98876479
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94448876
116EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93520526
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93520526
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93155199
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92409584
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.92267284
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90357937
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89932266
123TAF15_26573619_Chip-Seq_HEK293_Human0.89737249
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89700195
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89492575
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.88905157
127SMRT_27268052_Chip-Seq_Bcells_Human0.88845257
128VDR_24763502_ChIP-Seq_THP-1_Human0.88530324
129* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88418869
130* P53_22387025_ChIP-Seq_ESCs_Mouse0.87296078
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.86558108
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86041371
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85715235
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85619177
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84883324
136* PU1_27457419_Chip-Seq_LIVER_Mouse0.84691588
137SCL_19346495_ChIP-Seq_HPC-7_Human0.83722265
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.83687073
139STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83386690
140SPI1_23547873_ChIP-Seq_NB4_Human0.82416201
141* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82265284
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81637112
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81444943
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81385302
145RUNX2_22187159_ChIP-Seq_PCA_Human0.81214982
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.81006713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.90665263
2MP0001835_abnormal_antigen_presentation3.87580427
3MP0004859_abnormal_synaptic_plasticity3.08109291
4MP0004510_myositis2.98116334
5MP0003172_abnormal_lysosome_physiology2.90079532
6MP0005058_abnormal_lysosome_morphology2.46628395
7MP0003303_peritoneal_inflammation2.46053512
8MP0003183_abnormal_peptide_metabolism2.42576715
9MP0005387_immune_system_phenotype2.39719945
10MP0001790_abnormal_immune_system2.39719945
11MP0003646_muscle_fatigue2.36275325
12MP0009046_muscle_twitch2.27648026
13MP0002419_abnormal_innate_immunity2.25828685
14MP0003195_calcinosis2.24809584
15MP0005000_abnormal_immune_tolerance2.17862082
16MP0000015_abnormal_ear_pigmentation2.17766273
17MP0001800_abnormal_humoral_immune2.14848147
18MP0002452_abnormal_antigen_presenting2.14016995
19MP0005174_abnormal_tail_pigmentation2.11296232
20MP0002735_abnormal_chemical_nociception2.10115341
21MP0001968_abnormal_touch/_nociception2.09104638
22MP0008260_abnormal_autophagy1.87327672
23MP0002723_abnormal_immune_serum1.85877534
24MP0004270_analgesia1.85789555
25MP0006082_CNS_inflammation1.85107963
26MP0002148_abnormal_hypersensitivity_rea1.84972020
27MP0003436_decreased_susceptibility_to1.81697886
28MP0005310_abnormal_salivary_gland1.81605708
29MP0005671_abnormal_response_to1.75093705
30MP0005167_abnormal_blood-brain_barrier1.74680943
31MP0005646_abnormal_pituitary_gland1.74589740
32MP0001819_abnormal_immune_cell1.71678320
33MP0008877_abnormal_DNA_methylation1.70894018
34MP0005645_abnormal_hypothalamus_physiol1.70406694
35MP0002736_abnormal_nociception_after1.70403945
36MP0004885_abnormal_endolymph1.70316697
37MP0002420_abnormal_adaptive_immunity1.69344378
38MP0003880_abnormal_central_pattern1.68587314
39MP0003635_abnormal_synaptic_transmissio1.68424967
40MP0009785_altered_susceptibility_to1.67878726
41MP0002064_seizures1.65240710
42MP0005025_abnormal_response_to1.63328754
43MP0004858_abnormal_nervous_system1.62089380
44MP0003690_abnormal_glial_cell1.58296174
45MP0002822_catalepsy1.55836309
46MP0002876_abnormal_thyroid_physiology1.52964843
47MP0000685_abnormal_immune_system1.51024097
48MP0001986_abnormal_taste_sensitivity1.46814485
49MP0009745_abnormal_behavioral_response1.46081917
50MP0001502_abnormal_circadian_rhythm1.45005405
51MP0004130_abnormal_muscle_cell1.43701056
52MP0002557_abnormal_social/conspecific_i1.39442153
53MP0003879_abnormal_hair_cell1.38689149
54MP0003011_delayed_dark_adaptation1.38373818
55MP0005464_abnormal_platelet_physiology1.35031431
56MP0000778_abnormal_nervous_system1.34282505
57MP0004142_abnormal_muscle_tone1.33087646
58MP0001440_abnormal_grooming_behavior1.32815939
59MP0002063_abnormal_learning/memory/cond1.29476346
60MP0002572_abnormal_emotion/affect_behav1.26180764
61MP0003122_maternal_imprinting1.25904166
62MP0009278_abnormal_bone_marrow1.25645919
63MP0002006_tumorigenesis1.25471951
64MP0002734_abnormal_mechanical_nocicepti1.24981873
65MP0002067_abnormal_sensory_capabilities1.22822532
66MP0003045_fibrosis1.22484234
67MP0003329_amyloid_beta_deposits1.22299448
68MP0003075_altered_response_to1.21599616
69MP0005253_abnormal_eye_physiology1.21093337
70MP0002733_abnormal_thermal_nociception1.20575987
71MP0001970_abnormal_pain_threshold1.20179553
72MP0004947_skin_inflammation1.18872629
73MP0002166_altered_tumor_susceptibility1.17604475
74MP0003632_abnormal_nervous_system1.17337251
75MP0001501_abnormal_sleep_pattern1.16659260
76MP0000716_abnormal_immune_system1.13954509
77MP0000604_amyloidosis1.13598432
78MP0005423_abnormal_somatic_nervous1.13427277
79MP0000371_diluted_coat_color1.08355683
80MP0000955_abnormal_spinal_cord1.07443620
81MP0002638_abnormal_pupillary_reflex1.06516754
82MP0002398_abnormal_bone_marrow1.05854611
83MP0001486_abnormal_startle_reflex1.04904459
84MP0003300_gastrointestinal_ulcer1.04413873
85MP0002405_respiratory_system_inflammati1.02839324
86MP0002998_abnormal_bone_remodeling1.02270113
87MP0002272_abnormal_nervous_system1.01871838
88MP0002882_abnormal_neuron_morphology1.01329830
89MP0004484_altered_response_of1.01206927
90MP0002066_abnormal_motor_capabilities/c1.01186995
91MP0002909_abnormal_adrenal_gland0.99798198
92MP0002090_abnormal_vision0.99570155
93MP0002837_dystrophic_cardiac_calcinosis0.98472441
94MP0003634_abnormal_glial_cell0.98283433
95MP0001845_abnormal_inflammatory_respons0.98085676
96MP0008569_lethality_at_weaning0.95734554
97MP0005171_absent_coat_pigmentation0.94906856
98MP0001485_abnormal_pinna_reflex0.94758257
99MP0004811_abnormal_neuron_physiology0.93822559
100MP0003633_abnormal_nervous_system0.93342110
101MP0000920_abnormal_myelination0.91687739
102MP0001533_abnormal_skeleton_physiology0.91684228
103MP0003091_abnormal_cell_migration0.90195353
104MP0003787_abnormal_imprinting0.89608141
105MP0005076_abnormal_cell_differentiation0.89175267
106MP0002009_preneoplasia0.86354139
107MP0004215_abnormal_myocardial_fiber0.86180362
108MP0000689_abnormal_spleen_morphology0.86038937
109MP0004145_abnormal_muscle_electrophysio0.85113253
110MP0005166_decreased_susceptibility_to0.84432153
111MP0002653_abnormal_ependyma_morphology0.84078679
112MP0003448_altered_tumor_morphology0.83382900
113MP0002229_neurodegeneration0.83053513
114MP0004742_abnormal_vestibular_system0.82154368
115MP0001905_abnormal_dopamine_level0.82006244
116MP0005448_abnormal_energy_balance0.81946136
117MP0010386_abnormal_urinary_bladder0.80918038
118MP0001177_atelectasis0.80393736
119MP0000631_abnormal_neuroendocrine_gland0.80203444
120MP0003631_nervous_system_phenotype0.79746461
121MP0009764_decreased_sensitivity_to0.79153737
122MP0002184_abnormal_innervation0.78754381
123MP0002429_abnormal_blood_cell0.77077467
124MP0001984_abnormal_olfaction0.76309860
125MP0001851_eye_inflammation0.75912690
126MP0006276_abnormal_autonomic_nervous0.74035352
127MP0008057_abnormal_DNA_replication0.73955523
128MP0005551_abnormal_eye_electrophysiolog0.73472560
129MP0001873_stomach_inflammation0.73408431
130MP0008872_abnormal_physiological_respon0.73177849
131MP0005409_darkened_coat_color0.73163326
132MP0005535_abnormal_body_temperature0.72554346
133MP0002095_abnormal_skin_pigmentation0.71939096
134MP0005187_abnormal_penis_morphology0.71440708
135MP0003828_pulmonary_edema0.69849070
136MP0002332_abnormal_exercise_endurance0.69456336
137MP0003724_increased_susceptibility_to0.68600857
138MP0005257_abnormal_intraocular_pressure0.66920786
139MP0008004_abnormal_stomach_pH0.66649917
140MP0002693_abnormal_pancreas_physiology0.66366856
141MP0001963_abnormal_hearing_physiology0.65436467
142MP0004085_abnormal_heartbeat0.65263433
143MP0005386_behavior/neurological_phenoty0.65085197
144MP0004924_abnormal_behavior0.65085197
145MP0002971_abnormal_brown_adipose0.64824587
146MP0002277_abnormal_respiratory_mucosa0.64790728
147MP0002102_abnormal_ear_morphology0.64041592
148MP0004036_abnormal_muscle_relaxation0.62853589
149MP0002152_abnormal_brain_morphology0.62402171
150MP0004043_abnormal_pH_regulation0.61353008
151MP0002069_abnormal_eating/drinking_beha0.59986613
152MP0010329_abnormal_lipoprotein_level0.57775128
153MP0002752_abnormal_somatic_nervous0.57346209
154MP0002078_abnormal_glucose_homeostasis0.56985821

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.90680963
2Recurrent bacterial skin infections (HP:0005406)5.28252326
3Increased cerebral lipofuscin (HP:0011813)4.32950084
4Eczematoid dermatitis (HP:0000976)4.30231512
5Hyperventilation (HP:0002883)4.24826179
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.00225477
7Febrile seizures (HP:0002373)3.54700990
8Abnormality of glycolipid metabolism (HP:0010969)3.47563448
9Abnormality of liposaccharide metabolism (HP:0010968)3.47563448
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.47563448
11Abnormality of macrophages (HP:0004311)3.42627290
12Gingivitis (HP:0000230)3.24427898
13Focal motor seizures (HP:0011153)3.20308112
14Stomatitis (HP:0010280)3.15540257
15Mediastinal lymphadenopathy (HP:0100721)3.11728150
16Focal seizures (HP:0007359)3.09382502
17Recurrent gram-negative bacterial infections (HP:0005420)3.02076173
18Hemiplegia (HP:0002301)2.97409521
19Recurrent skin infections (HP:0001581)2.92725280
20Prostate neoplasm (HP:0100787)2.86424518
21Progressive cerebellar ataxia (HP:0002073)2.81981887
22Broad-based gait (HP:0002136)2.79682972
23Epileptiform EEG discharges (HP:0011182)2.68586975
24Recurrent fungal infections (HP:0002841)2.67793012
25Supranuclear gaze palsy (HP:0000605)2.66940015
26Optic neuritis (HP:0100653)2.65836470
27Retrobulbar optic neuritis (HP:0100654)2.65836470
28Hemiparesis (HP:0001269)2.63875610
29Chronic obstructive pulmonary disease (HP:0006510)2.63150786
30Obstructive lung disease (HP:0006536)2.63150786
31Amyotrophic lateral sclerosis (HP:0007354)2.62299851
32Loss of speech (HP:0002371)2.61942107
33Abnormal eating behavior (HP:0100738)2.59254085
34Vasculitis (HP:0002633)2.59030863
35Absent frontal sinuses (HP:0002688)2.52379972
36Pheochromocytoma (HP:0002666)2.52063453
37Periodontitis (HP:0000704)2.51008885
38Submucous cleft hard palate (HP:0000176)2.49562193
39Pancreatic cysts (HP:0001737)2.49146313
40EEG with generalized epileptiform discharges (HP:0011198)2.49127593
41Protruding tongue (HP:0010808)2.47570348
42Colitis (HP:0002583)2.46337235
43Polyphagia (HP:0002591)2.41678722
44Epileptic encephalopathy (HP:0200134)2.40997431
45Myokymia (HP:0002411)2.39434032
46Papilledema (HP:0001085)2.39253172
47Hypsarrhythmia (HP:0002521)2.39152049
48Atonic seizures (HP:0010819)2.36415328
49Dyskinesia (HP:0100660)2.35938170
50Disinhibition (HP:0000734)2.35782525
51Elevated erythrocyte sedimentation rate (HP:0003565)2.35177408
52Mutism (HP:0002300)2.34759344
53Ulnar claw (HP:0001178)2.33745029
54Hematochezia (HP:0002573)2.33257644
55Inability to walk (HP:0002540)2.32504806
56Dysdiadochokinesis (HP:0002075)2.31837149
57Polydipsia (HP:0001959)2.31689554
58Abnormal drinking behavior (HP:0030082)2.31689554
59Cellulitis (HP:0100658)2.28347200
60Increased density of long bones (HP:0006392)2.26900963
61Action tremor (HP:0002345)2.25731398
62Progressive visual loss (HP:0000529)2.24206721
63Fair hair (HP:0002286)2.22530137
64Vacuolated lymphocytes (HP:0001922)2.21859732
65Inappropriate behavior (HP:0000719)2.21083265
66Agammaglobulinemia (HP:0004432)2.21015657
67Orchitis (HP:0100796)2.20934502
68Limb dystonia (HP:0002451)2.19403250
69Recurrent cutaneous fungal infections (HP:0011370)2.19224506
70Chronic mucocutaneous candidiasis (HP:0002728)2.19224506
71Urinary bladder sphincter dysfunction (HP:0002839)2.19024478
72Dysostosis multiplex (HP:0000943)2.18766647
73Myositis (HP:0100614)2.17485189
74Difficulty running (HP:0009046)2.16045144
75Segmental peripheral demyelination/remyelination (HP:0003481)2.15250807
76Generalized hypopigmentation of hair (HP:0011358)2.14753305
77Abnormality of the renal cortex (HP:0011035)2.13776896
78Autoimmune thrombocytopenia (HP:0001973)2.13581824
79Recurrent viral infections (HP:0004429)2.12174298
80Osteomyelitis (HP:0002754)2.11690988
81Axonal loss (HP:0003447)2.10585668
82Thick nail (HP:0001805)2.09263915
83Neuroendocrine neoplasm (HP:0100634)2.08929145
84Tubulointerstitial nephritis (HP:0001970)2.07879035
85Premature loss of primary teeth (HP:0006323)2.07037103
86Attenuation of retinal blood vessels (HP:0007843)2.06985744
87Abnormality of the fingertips (HP:0001211)2.06922121
88Ventricular fibrillation (HP:0001663)2.04162818
89Oligodactyly (hands) (HP:0001180)2.03335829
90Pancreatic fibrosis (HP:0100732)2.02995693
91Abnormality of binocular vision (HP:0011514)2.02781255
92Diplopia (HP:0000651)2.02781255
93Widely spaced teeth (HP:0000687)2.02765828
94Abnormal hair whorl (HP:0010721)2.00794455
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00458832
96Agitation (HP:0000713)1.99861956
97Gastrointestinal stroma tumor (HP:0100723)1.99751732
98Increased circulating renin level (HP:0000848)1.98281687
99Metabolic alkalosis (HP:0200114)1.98091115
100Ocular albinism (HP:0001107)1.98001323
101Recurrent pneumonia (HP:0006532)1.97174049
102Truncal ataxia (HP:0002078)1.96794718
103Abnormality of ocular smooth pursuit (HP:0000617)1.96731918
104Abnormality of the corticospinal tract (HP:0002492)1.95699463
105Gaze-evoked nystagmus (HP:0000640)1.94974185
106Meningitis (HP:0001287)1.94312303
107Visual hallucinations (HP:0002367)1.93471139
108Dialeptic seizures (HP:0011146)1.92776643
109Hip dysplasia (HP:0001385)1.92742358
110J-shaped sella turcica (HP:0002680)1.92538617
111Neuronal loss in central nervous system (HP:0002529)1.92207534
112Pulmonary infiltrates (HP:0002113)1.92008820
113Impaired smooth pursuit (HP:0007772)1.91747589
114True hermaphroditism (HP:0010459)1.91043770
115Decreased circulating renin level (HP:0003351)1.90850322
116Restrictive lung disease (HP:0002091)1.90440012
117Abnormality of the renal medulla (HP:0100957)1.89560536
118Spastic gait (HP:0002064)1.88348022
119Generalized tonic-clonic seizures (HP:0002069)1.88291917
120Clumsiness (HP:0002312)1.88072661
121Absent speech (HP:0001344)1.87811582
122Progressive inability to walk (HP:0002505)1.87476825
123Bradykinesia (HP:0002067)1.87119502
124Interstitial pulmonary disease (HP:0006530)1.85843740
125Hypokalemic alkalosis (HP:0001949)1.85692814
126Generalized hypopigmentation (HP:0007513)1.84802057
127Prolonged QT interval (HP:0001657)1.84649848
128Impaired vibratory sensation (HP:0002495)1.84272704
129Poor eye contact (HP:0000817)1.83952559
130Abolished electroretinogram (ERG) (HP:0000550)1.83557806
131Chronic hepatic failure (HP:0100626)1.83432178
132Abnormality of polysaccharide metabolism (HP:0011012)1.83143641
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83143641
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83143641
135Syncope (HP:0001279)1.83036036
136Agnosia (HP:0010524)1.82962085
137Menstrual irregularities (HP:0000858)1.80711162
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80679040
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.80679040
140Inflammation of the large intestine (HP:0002037)1.80647382
141Iris hypopigmentation (HP:0007730)1.80484358
142Truncal obesity (HP:0001956)1.80117509
143Aqueductal stenosis (HP:0002410)1.79982910
144Progressive hearing impairment (HP:0001730)1.79678211
145Stomach cancer (HP:0012126)1.79120877
146Slow saccadic eye movements (HP:0000514)1.78096052
147Onion bulb formation (HP:0003383)1.77065173
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76948408
149Genetic anticipation (HP:0003743)1.75784609
150Upper motor neuron abnormality (HP:0002127)1.75386144
151Congenital stationary night blindness (HP:0007642)1.75159853
152Progressive sensorineural hearing impairment (HP:0000408)1.74665020
153Absence seizures (HP:0002121)1.73692190
154Nephronophthisis (HP:0000090)1.73195649
155Papillary thyroid carcinoma (HP:0002895)1.72577686
156Postural instability (HP:0002172)1.72140817
157Impaired vibration sensation in the lower limbs (HP:0002166)1.71703374
158Excessive salivation (HP:0003781)1.71466888
159Drooling (HP:0002307)1.71466888
160Hypothermia (HP:0002045)1.70407975
161Thyroiditis (HP:0100646)1.67764981
162Congenital sensorineural hearing impairment (HP:0008527)1.67121303
163Status epilepticus (HP:0002133)1.65626078
164T lymphocytopenia (HP:0005403)1.65316014
165Gait imbalance (HP:0002141)1.64760375
166Lower limb muscle weakness (HP:0007340)1.64286688
167Increased CSF protein (HP:0002922)1.63700823
168Intention tremor (HP:0002080)1.63617599
169Abnormality of salivation (HP:0100755)1.63290129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.23166566
2FRK3.98818321
3MAP3K143.19111115
4MAP3K132.86830854
5MARK12.84929067
6MAP4K12.84402357
7IRAK32.59088049
8MAP3K92.50203044
9TYK22.28486671
10JAK12.19166808
11IRAK42.14086507
12PINK12.06918091
13NTRK32.00524162
14ACVR1B1.92716216
15DAPK21.90465086
16SIK21.86015951
17BMPR21.81857273
18FGR1.80864491
19FES1.80523354
20TAOK31.75459819
21IKBKE1.58162842
22KIT1.56502674
23BLK1.54153594
24ADRBK21.52338862
25IKBKB1.48969718
26TBK11.48803383
27CSF1R1.46435623
28SYK1.44492514
29PAK31.42399838
30SGK21.38342487
31CAMK11.37239899
32SGK31.36524403
33NLK1.31771901
34HCK1.31469980
35TXK1.29532280
36INSRR1.25700458
37GRK51.23227363
38CAMK1G1.21043697
39GRK71.17114056
40EPHA41.16704026
41PRPF4B1.14826044
42CAMKK11.10408982
43GRK11.10159665
44NEK61.09821684
45CAMK41.09212010
46MAP2K41.07087372
47CDK121.06280985
48NEK91.04750892
49MINK11.03984085
50PRKCH1.03802920
51TNIK1.01903678
52WNK31.00766109
53CAMKK20.99478110
54CHUK0.98785228
55MARK30.97909372
56CAMK1D0.97413572
57PAK60.95795114
58PRKCG0.95744078
59PLK20.93658888
60SGK4940.92957377
61SGK2230.92957377
62PDK10.90894814
63KSR20.90797268
64DYRK1A0.90009433
65NTRK10.89602304
66JAK30.88927408
67AKT30.87381166
68PHKG10.87364102
69PHKG20.87364102
70BRD40.85469077
71LYN0.85322295
72PNCK0.85212800
73MARK20.85142234
74MATK0.84872584
75SGK10.84393830
76UHMK10.84000605
77WNK10.83667520
78CSK0.82288770
79OXSR10.79993309
80CDK50.77273639
81PIK3CG0.75853265
82MAP3K20.74802284
83LCK0.74475798
84MAP3K70.72884610
85SIK30.71537538
86CDK30.71515667
87PIK3CA0.71167562
88CAMK2A0.69888542
89YES10.69517986
90MAP2K70.68976500
91STK380.68539823
92CSNK1G20.68502371
93HIPK20.68285125
94PRKCQ0.66554066
95TGFBR20.64428222
96PDPK10.64194507
97ARAF0.63893746
98STK240.63070230
99DAPK10.62748721
100FYN0.62012385
101MAPK70.62009138
102MAP3K40.61969257
103FGFR20.61417500
104PKN10.61288340
105OBSCN0.61099779
106ADRBK10.60597172
107TYRO30.60040952
108JAK20.59572537
109FGFR30.59434854
110MAP2K60.59349465
111BMPR1B0.59062361
112CASK0.58567036
113MAPK130.58127003
114PRKCZ0.57488637
115PRKAA20.57250626
116MAPK100.56958159
117RPS6KA20.56119205
118STK110.55361789
119NTRK20.53413288
120PRKCE0.52690721
121RET0.52076968
122ERBB20.50091180
123PRKAA10.49969644
124FER0.49173467
125PRKG10.48167848
126MAP4K20.47893365
127MAP3K120.46911685
128CSNK1G10.46232163
129EPHA30.45566435
130RPS6KA30.45445467
131EGFR0.45021400
132CAMK2B0.44354942
133ALK0.44093481
134MAPKAPK50.43402423
135PRKCD0.42472190
136TNK20.42393052
137EPHB10.40128812
138ABL10.38846043
139ZAP700.34283069
140PTK2B0.34217266
141MOS0.31409750
142IRAK20.31184574
143MAPK120.30990456

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.99196035
2Leishmaniasis_Homo sapiens_hsa051401.86168426
3Osteoclast differentiation_Homo sapiens_hsa043801.84934532
4Synaptic vesicle cycle_Homo sapiens_hsa047211.78826654
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64515061
6Olfactory transduction_Homo sapiens_hsa047401.63766817
7Tuberculosis_Homo sapiens_hsa051521.63532991
8Circadian rhythm_Homo sapiens_hsa047101.62213385
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54494221
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.51589322
11Lysosome_Homo sapiens_hsa041421.51450007
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.49582666
13Phototransduction_Homo sapiens_hsa047441.47314469
14Nitrogen metabolism_Homo sapiens_hsa009101.43898172
15Rheumatoid arthritis_Homo sapiens_hsa053231.40294781
16Morphine addiction_Homo sapiens_hsa050321.38452621
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36447815
18Nicotine addiction_Homo sapiens_hsa050331.32457613
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31747851
20Chemokine signaling pathway_Homo sapiens_hsa040621.30648582
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30284493
22Type II diabetes mellitus_Homo sapiens_hsa049301.28675925
23Cocaine addiction_Homo sapiens_hsa050301.27239183
24Pertussis_Homo sapiens_hsa051331.24339990
25Long-term potentiation_Homo sapiens_hsa047201.23162799
26Phagosome_Homo sapiens_hsa041451.19079975
27Circadian entrainment_Homo sapiens_hsa047131.17981747
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17628803
29Hematopoietic cell lineage_Homo sapiens_hsa046401.15841392
30Collecting duct acid secretion_Homo sapiens_hsa049661.15672461
31Glutamatergic synapse_Homo sapiens_hsa047241.15157302
32African trypanosomiasis_Homo sapiens_hsa051431.14450392
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14364824
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12942385
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09917281
36Influenza A_Homo sapiens_hsa051641.09788809
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09390992
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09216274
39Malaria_Homo sapiens_hsa051441.09101486
40Salmonella infection_Homo sapiens_hsa051321.08833464
41TNF signaling pathway_Homo sapiens_hsa046681.08647379
42Cholinergic synapse_Homo sapiens_hsa047251.08555822
43Measles_Homo sapiens_hsa051621.08306145
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05834892
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.05737758
46Salivary secretion_Homo sapiens_hsa049701.04957360
47Dorso-ventral axis formation_Homo sapiens_hsa043201.04366439
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04093650
49Inositol phosphate metabolism_Homo sapiens_hsa005621.03914183
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.03782532
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.01550460
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99555252
53GABAergic synapse_Homo sapiens_hsa047270.98649204
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98352303
55Ether lipid metabolism_Homo sapiens_hsa005650.97435521
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97051576
57Staphylococcus aureus infection_Homo sapiens_hsa051500.96910526
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96715611
59Toxoplasmosis_Homo sapiens_hsa051450.95921444
60Graft-versus-host disease_Homo sapiens_hsa053320.95571455
61T cell receptor signaling pathway_Homo sapiens_hsa046600.94993074
62ABC transporters_Homo sapiens_hsa020100.94633513
63Dopaminergic synapse_Homo sapiens_hsa047280.94560449
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.92907714
65Ovarian steroidogenesis_Homo sapiens_hsa049130.91553273
66Renin secretion_Homo sapiens_hsa049240.91079395
67Serotonergic synapse_Homo sapiens_hsa047260.89235965
68Butanoate metabolism_Homo sapiens_hsa006500.88951301
69Insulin secretion_Homo sapiens_hsa049110.88792569
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.88770478
71Calcium signaling pathway_Homo sapiens_hsa040200.88691047
72Pancreatic secretion_Homo sapiens_hsa049720.87198651
73GnRH signaling pathway_Homo sapiens_hsa049120.86523675
74Taste transduction_Homo sapiens_hsa047420.85713498
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84671275
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84499253
77Long-term depression_Homo sapiens_hsa047300.83689649
78Oxytocin signaling pathway_Homo sapiens_hsa049210.83042711
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.82544435
80Type I diabetes mellitus_Homo sapiens_hsa049400.81996527
81Regulation of autophagy_Homo sapiens_hsa041400.81501915
82Gastric acid secretion_Homo sapiens_hsa049710.81473360
83Apoptosis_Homo sapiens_hsa042100.81224313
84Amphetamine addiction_Homo sapiens_hsa050310.81172586
85Shigellosis_Homo sapiens_hsa051310.78857646
86Glioma_Homo sapiens_hsa052140.78757855
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.78641271
88MAPK signaling pathway_Homo sapiens_hsa040100.78433881
89Hepatitis C_Homo sapiens_hsa051600.76698788
90Legionellosis_Homo sapiens_hsa051340.75791728
91Hepatitis B_Homo sapiens_hsa051610.75443793
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75054375
93cAMP signaling pathway_Homo sapiens_hsa040240.74988841
94Allograft rejection_Homo sapiens_hsa053300.74870436
95Endocytosis_Homo sapiens_hsa041440.74808733
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74371690
97ErbB signaling pathway_Homo sapiens_hsa040120.73004065
98Fatty acid biosynthesis_Homo sapiens_hsa000610.72843743
99Other glycan degradation_Homo sapiens_hsa005110.72274313
100Tryptophan metabolism_Homo sapiens_hsa003800.72083041
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71657791
102Pancreatic cancer_Homo sapiens_hsa052120.70336027
103Linoleic acid metabolism_Homo sapiens_hsa005910.70137736
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68932260
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68636346
106Choline metabolism in cancer_Homo sapiens_hsa052310.68329781
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67389651
108FoxO signaling pathway_Homo sapiens_hsa040680.66995887
109Sphingolipid metabolism_Homo sapiens_hsa006000.66324574
110Platelet activation_Homo sapiens_hsa046110.65889737
111mTOR signaling pathway_Homo sapiens_hsa041500.64911496
112Primary immunodeficiency_Homo sapiens_hsa053400.64666463
113Chronic myeloid leukemia_Homo sapiens_hsa052200.64246534
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64107851
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63719880
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63700425
117Prolactin signaling pathway_Homo sapiens_hsa049170.63446777
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63283540
119VEGF signaling pathway_Homo sapiens_hsa043700.62937360
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62882746
121Glycerolipid metabolism_Homo sapiens_hsa005610.62596272
122Estrogen signaling pathway_Homo sapiens_hsa049150.62303369
123Ras signaling pathway_Homo sapiens_hsa040140.62191984
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61222826
125Bile secretion_Homo sapiens_hsa049760.59170200
126Gap junction_Homo sapiens_hsa045400.58858035
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.55778965
128Thyroid hormone synthesis_Homo sapiens_hsa049180.51653664
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50069040
130Rap1 signaling pathway_Homo sapiens_hsa040150.48123238
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.46744066
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46518670
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45391862
134Mineral absorption_Homo sapiens_hsa049780.44508338
135Axon guidance_Homo sapiens_hsa043600.43795987
136Insulin resistance_Homo sapiens_hsa049310.43251756
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41285409

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