PLEKHN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.21797607
2keratinization (GO:0031424)6.84478890
3establishment of skin barrier (GO:0061436)6.81198753
4regulation of water loss via skin (GO:0033561)6.32003446
5hemidesmosome assembly (GO:0031581)4.78464246
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63708822
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63708822
8keratinocyte differentiation (GO:0030216)4.42374558
9hair cycle (GO:0042633)4.35161404
10molting cycle (GO:0042303)4.35161404
11semaphorin-plexin signaling pathway (GO:0071526)4.33301481
12antigen processing and presentation of endogenous antigen (GO:0019883)4.27759477
13cell-substrate junction assembly (GO:0007044)4.20473608
14positive regulation by symbiont of host defense response (GO:0052509)4.12443531
15modulation by symbiont of host defense response (GO:0052031)4.12443531
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12443531
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12443531
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.12443531
19modulation by symbiont of host immune response (GO:0052553)4.12443531
20multicellular organismal water homeostasis (GO:0050891)3.89371669
21neutrophil activation involved in immune response (GO:0002283)3.88504319
22protein localization to endosome (GO:0036010)3.86550703
23activation of Rac GTPase activity (GO:0032863)3.84369314
24epithelial cell-cell adhesion (GO:0090136)3.79375094
25immunoglobulin mediated immune response (GO:0016064)3.74620045
26COPI coating of Golgi vesicle (GO:0048205)3.69664075
27Golgi transport vesicle coating (GO:0048200)3.69664075
28positive regulation of gamma-delta T cell activation (GO:0046645)3.66675624
29positive regulation of Cdc42 GTPase activity (GO:0043089)3.64954970
30cellular response to type I interferon (GO:0071357)3.61959458
31type I interferon signaling pathway (GO:0060337)3.61959458
32response to type I interferon (GO:0034340)3.61344302
33peptide cross-linking (GO:0018149)3.57490136
34positive regulation of interferon-alpha production (GO:0032727)3.52633560
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47477988
36positive regulation of epidermis development (GO:0045684)3.44900844
37endothelial cell chemotaxis (GO:0035767)3.44441482
38response to muramyl dipeptide (GO:0032495)3.42682501
39regulation of interferon-beta biosynthetic process (GO:0045357)3.41902893
40epidermal cell differentiation (GO:0009913)3.37467350
41positive regulation of keratinocyte differentiation (GO:0045618)3.35495426
42granulocyte activation (GO:0036230)3.35221551
43NIK/NF-kappaB signaling (GO:0038061)3.34446188
44regulation of interferon-alpha production (GO:0032647)3.34174107
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29952741
46regulation of hypersensitivity (GO:0002883)3.27336815
47neutrophil activation (GO:0042119)3.24726834
48positive regulation of natural killer cell differentiation (GO:0032825)3.22112125
49atrioventricular valve morphogenesis (GO:0003181)3.21646727
50water homeostasis (GO:0030104)3.19834529
51regulation of apoptotic process involved in morphogenesis (GO:1902337)3.19707738
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19465921
53skin morphogenesis (GO:0043589)3.19024216
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.18915583
55positive regulation of epidermal cell differentiation (GO:0045606)3.15873772
56regulation of vitamin D biosynthetic process (GO:0060556)3.14755981
57positive regulation of antigen processing and presentation (GO:0002579)3.12129174
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.11422113
59macrophage activation involved in immune response (GO:0002281)3.05967546
60focal adhesion assembly (GO:0048041)3.03962074
61cell-substrate adherens junction assembly (GO:0007045)3.03962074
62response to peptidoglycan (GO:0032494)3.02432010
63regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01464493
64apoptotic process involved in morphogenesis (GO:0060561)2.99600856
65interleukin-1-mediated signaling pathway (GO:0070498)2.99183294
66keratinocyte proliferation (GO:0043616)2.99127346
67cell-cell junction maintenance (GO:0045217)2.98968609
68negative regulation of viral release from host cell (GO:1902187)2.97719659
69response to interferon-alpha (GO:0035455)2.95495963
70negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92711845
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90884145
72negative regulation of erythrocyte differentiation (GO:0045647)2.90820838
73positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.89916463
74interferon-gamma-mediated signaling pathway (GO:0060333)2.89912713
75cellular response to interferon-alpha (GO:0035457)2.89781731
76adherens junction assembly (GO:0034333)2.89680424
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88378597
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86073155
79virion attachment to host cell (GO:0019062)2.85315051
80adhesion of symbiont to host cell (GO:0044650)2.85315051
81regulation of natural killer cell differentiation (GO:0032823)2.84190975
82germinal center formation (GO:0002467)2.83671135
83protein retention in ER lumen (GO:0006621)2.82588962
84activation of MAPKKK activity (GO:0000185)2.81579005
85interferon-gamma secretion (GO:0072643)2.81251709
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80175171
87negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.78469091
88regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.76385270
89cell adhesion mediated by integrin (GO:0033627)2.74539053
90response to progesterone (GO:0032570)2.74215092
91regulation of gamma-delta T cell activation (GO:0046643)2.74188887
92skeletal muscle adaptation (GO:0043501)2.72529300
93positive regulation of histone deacetylation (GO:0031065)2.72486718
94detection of bacterium (GO:0016045)2.71896000
95detection of other organism (GO:0098543)2.71641853
96mammary gland epithelial cell proliferation (GO:0033598)2.71421698
97mannose metabolic process (GO:0006013)2.71322302
98negative regulation of interleukin-2 production (GO:0032703)2.70889072
99striated muscle atrophy (GO:0014891)2.70707651
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70487997
101negative regulation of cell size (GO:0045792)2.67580153
102sphingosine metabolic process (GO:0006670)2.66838446
103myeloid cell activation involved in immune response (GO:0002275)2.65954955
104decidualization (GO:0046697)2.65521561
105barbed-end actin filament capping (GO:0051016)2.63894955
106B cell mediated immunity (GO:0019724)2.63335324
107GDP-mannose metabolic process (GO:0019673)2.62431250
108endocytic recycling (GO:0032456)2.62336930
109basement membrane organization (GO:0071711)2.62332563
110negative regulation of fatty acid transport (GO:2000192)2.62244144
111regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62121760
112leukocyte aggregation (GO:0070486)2.61801564
113Rho protein signal transduction (GO:0007266)2.61282093
114regulation of chronic inflammatory response (GO:0002676)2.60598857
115regulation of integrin activation (GO:0033623)2.59812873
116regulation of chemokine secretion (GO:0090196)2.57641487
117branching involved in mammary gland duct morphogenesis (GO:0060444)2.57492070
118embryonic process involved in female pregnancy (GO:0060136)2.57243471
119positive regulation of hair cycle (GO:0042635)2.57002854
120positive regulation of hair follicle development (GO:0051798)2.57002854
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.56880231
122regulation of cholesterol homeostasis (GO:2000188)2.56461565
123sphingoid metabolic process (GO:0046519)2.56095485
124cellular response to virus (GO:0098586)2.54643723
125negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.54176546
126cell differentiation involved in embryonic placenta development (GO:0060706)2.53462916
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53064936
128T-helper 1 type immune response (GO:0042088)2.52357546
129regulation of antigen processing and presentation (GO:0002577)2.52302550
130epidermis development (GO:0008544)2.52136703
131natural killer cell mediated cytotoxicity (GO:0042267)2.51877556
132natural killer cell mediated immunity (GO:0002228)2.51877556
133regulation of gamma-delta T cell differentiation (GO:0045586)2.51372741
134establishment of apical/basal cell polarity (GO:0035089)2.50230317
135negative regulation of viral genome replication (GO:0045071)2.49560345
136intermediate filament organization (GO:0045109)2.48791083
137wound healing, spreading of epidermal cells (GO:0035313)2.46866189
138response to host immune response (GO:0052572)2.45588664
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45588664
140retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45569286
141positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44705022
142regulation of early endosome to late endosome transport (GO:2000641)2.44172064
143positive regulation of interferon-beta production (GO:0032728)2.43794166
144positive regulation of chemokine biosynthetic process (GO:0045080)2.43572686
145hypotonic response (GO:0006971)2.43405812
146negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41979811
147diol metabolic process (GO:0034311)2.41330630
148vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40509903
149regulation of viral release from host cell (GO:1902186)2.39484776
150phospholipid scrambling (GO:0017121)2.39184535
151positive regulation of type 2 immune response (GO:0002830)2.38787018
152adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.37825359
153regulation of monocyte differentiation (GO:0045655)2.37246663
154activation of JUN kinase activity (GO:0007257)2.36670953
155positive regulation of interleukin-6 production (GO:0032755)2.36560493
156regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36389060
157regulation of vitamin metabolic process (GO:0030656)2.34589213
158negative regulation of stress fiber assembly (GO:0051497)2.33768958
159regulation of podosome assembly (GO:0071801)2.33679910
160positive regulation of B cell differentiation (GO:0045579)2.33656892
161T cell migration (GO:0072678)2.31895022
162myeloid dendritic cell differentiation (GO:0043011)2.31520778
163myeloid dendritic cell activation (GO:0001773)2.30965591
164negative regulation of interleukin-8 production (GO:0032717)2.30509661
165regulation of T-helper 1 cell differentiation (GO:0045625)2.30353128
166surfactant homeostasis (GO:0043129)2.30236426
167regulation of ruffle assembly (GO:1900027)2.29605471
168regulation of RIG-I signaling pathway (GO:0039535)2.28308594
169regulation of keratinocyte differentiation (GO:0045616)2.26614722
170positive regulation of heat generation (GO:0031652)2.22653613
171amyloid precursor protein catabolic process (GO:0042987)2.21152080
172cell junction maintenance (GO:0034331)2.20976190
173regulation of endothelial cell chemotaxis (GO:2001026)2.19293152
174negative regulation of keratinocyte proliferation (GO:0010839)2.19288065
175polarized epithelial cell differentiation (GO:0030859)2.19141866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.59998459
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.10478103
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.37589182
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.63888573
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.39731924
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.30404716
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80609729
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75011588
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.66053870
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52101371
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50373486
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49291049
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47991157
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41844379
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.32813017
16P63_26484246_Chip-Seq_KERATINOCYTES_Human2.31412044
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19329917
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.08530734
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06503988
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06359383
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02016900
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.94023734
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84622974
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83414131
25* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.74140998
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.70463897
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.69016823
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68661257
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68661257
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.67755265
31TCF7_22412390_ChIP-Seq_EML_Mouse1.66046349
32SCL_19346495_ChIP-Seq_HPC-7_Human1.64113188
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60796257
34MAF_26560356_Chip-Seq_TH1_Human1.60336058
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57762491
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56649849
37* P68_20966046_ChIP-Seq_HELA_Human1.56013369
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56003350
39* KDM2B_26808549_Chip-Seq_K562_Human1.51911967
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51647717
41VDR_21846776_ChIP-Seq_THP-1_Human1.51158254
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50790184
43GATA1_22025678_ChIP-Seq_K562_Human1.47132528
44RUNX_20019798_ChIP-Seq_JUKART_Human1.46097452
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45959964
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.45518455
47VDR_24763502_ChIP-Seq_THP-1_Human1.44270061
48MYB_26560356_Chip-Seq_TH2_Human1.43221998
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42920889
50TP53_22127205_ChIP-Seq_IMR90_Human1.42646940
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41667937
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40587228
53SMC4_20622854_ChIP-Seq_HELA_Human1.39655968
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.38467165
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36818086
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36504077
57* SA1_27219007_Chip-Seq_ERYTHROID_Human1.36393016
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35341089
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34597460
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34279856
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34024518
62* KDM2B_26808549_Chip-Seq_DND41_Human1.33666542
63* ESR2_21235772_ChIP-Seq_MCF-7_Human1.32364073
64* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31806383
65UTX_26944678_Chip-Seq_JUKART_Human1.31054152
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.29848390
67* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27519973
68SPI1_23127762_ChIP-Seq_K562_Human1.26165286
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.25804002
70* CREB1_26743006_Chip-Seq_LNCaP_Human1.25803772
71PU_27001747_Chip-Seq_BMDM_Mouse1.25406702
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24795192
73MYB_26560356_Chip-Seq_TH1_Human1.22602480
74* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21427576
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21215032
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20869081
77CLOCK_20551151_ChIP-Seq_293T_Human1.20456759
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20219593
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20136329
80LXR_22292898_ChIP-Seq_THP-1_Human1.19990820
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19453309
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19210439
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18323226
84MYC_22102868_ChIP-Seq_BL_Human1.18182263
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16757640
86VDR_24787735_ChIP-Seq_THP-1_Human1.16739625
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.16737956
88SPI1_23547873_ChIP-Seq_NB4_Human1.15706282
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15610163
90CTCF_27219007_Chip-Seq_Bcells_Human1.15269607
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15227446
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14677678
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.13740152
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13165364
95* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10778278
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10528001
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10100254
98SOX2_20726797_ChIP-Seq_SW620_Human1.10050964
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09249366
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09034897
101BCL6_27268052_Chip-Seq_Bcells_Human1.07659756
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.07446432
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07294548
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07127862
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05906653
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04561443
107KLF5_25053715_ChIP-Seq_YYC3_Human1.04225480
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.03299967
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03241127
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02976541
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02834465
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01959908
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01822512
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01137922
115* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00742951
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99595094
117TP63_23658742_ChIP-Seq_EP156T_Human0.99085808
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99075754
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98777277
120* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98772845
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.98402178
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97651978
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97512332
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96684903
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.96572767
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96160946
127GATA3_27048872_Chip-Seq_THYMUS_Human0.96116846
128GATA6_25053715_ChIP-Seq_YYC3_Human0.95862054
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95417375
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.94444804
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94408983
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94234893
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94199248
134TP63_22573176_ChIP-Seq_HFKS_Human0.93241349
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92873125
136E2F1_20622854_ChIP-Seq_HELA_Human0.92798196
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92712860
138CJUN_26792858_Chip-Seq_BT549_Human0.91209230
139* UBF1/2_26484160_Chip-Seq_HMECs_Human0.90777126
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90044673
141GATA3_26560356_Chip-Seq_TH2_Human0.89010017
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88893098
143ATF3_27146783_Chip-Seq_COLON_Human0.86009778
144* MAF_26560356_Chip-Seq_TH2_Human0.85018497
145ZNF263_19887448_ChIP-Seq_K562_Human0.84311106
146JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84259430
147BCOR_27268052_Chip-Seq_Bcells_Human0.83093837
148EGR1_19032775_ChIP-ChIP_M12_Human0.82814987
149* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81750592
150JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80945983
151GATA2_19941826_ChIP-Seq_K562_Human0.80884466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.19810883
2MP0010234_abnormal_vibrissa_follicle4.83943029
3MP0005275_abnormal_skin_tensile4.58349183
4MP0005501_abnormal_skin_physiology3.31725341
5MP0004947_skin_inflammation3.22285144
6MP0002254_reproductive_system_inflammat2.78932089
7MP0002060_abnormal_skin_morphology2.74893890
8MP0003453_abnormal_keratinocyte_physiol2.74778270
9MP0001216_abnormal_epidermal_layer2.63208743
10MP0010352_gastrointestinal_tract_polyps2.49107311
11MP0001835_abnormal_antigen_presentation2.45617566
12MP0010678_abnormal_skin_adnexa2.38854714
13MP0004381_abnormal_hair_follicle2.30815630
14MP0000383_abnormal_hair_follicle2.24205210
15MP0003436_decreased_susceptibility_to2.24062513
16MP0010771_integument_phenotype2.17225718
17MP0000579_abnormal_nail_morphology2.12539668
18MP0000685_abnormal_immune_system2.06005592
19MP0003705_abnormal_hypodermis_morpholog2.01359589
20MP0002098_abnormal_vibrissa_morphology2.01237268
21MP0003303_peritoneal_inflammation1.99783100
22MP0009785_altered_susceptibility_to1.95702636
23MP0001790_abnormal_immune_system1.93599023
24MP0005387_immune_system_phenotype1.93599023
25MP0002148_abnormal_hypersensitivity_rea1.89728265
26MP0002166_altered_tumor_susceptibility1.87486485
27MP0005000_abnormal_immune_tolerance1.80199399
28MP0005025_abnormal_response_to1.77317026
29MP0003941_abnormal_skin_development1.74979673
30MP0001800_abnormal_humoral_immune1.72052531
31MP0000427_abnormal_hair_cycle1.71679998
32MP0002006_tumorigenesis1.70546494
33MP0000647_abnormal_sebaceous_gland1.69614034
34MP0003566_abnormal_cell_adhesion1.68512840
35MP0002452_abnormal_antigen_presenting1.66242250
36MP0000377_abnormal_hair_follicle1.65163794
37MP0002419_abnormal_innate_immunity1.64028375
38MP0000566_synostosis1.59833522
39MP0009278_abnormal_bone_marrow1.58067713
40MP0000762_abnormal_tongue_morphology1.56429562
41MP0001851_eye_inflammation1.54767624
42MP0002723_abnormal_immune_serum1.54664830
43MP0003191_abnormal_cellular_cholesterol1.52513938
44MP0000678_abnormal_parathyroid_gland1.52240249
45MP0005409_darkened_coat_color1.52173189
46MP0004510_myositis1.52077307
47MP0001191_abnormal_skin_condition1.48243641
48MP0005397_hematopoietic_system_phenotyp1.44697855
49MP0001545_abnormal_hematopoietic_system1.44697855
50MP0002877_abnormal_melanocyte_morpholog1.44573503
51MP0001819_abnormal_immune_cell1.43923490
52MP0009931_abnormal_skin_appearance1.43320724
53MP0005671_abnormal_response_to1.42721653
54MP0003300_gastrointestinal_ulcer1.41722995
55MP0002420_abnormal_adaptive_immunity1.41052294
56MP0004264_abnormal_extraembryonic_tissu1.40518098
57MP0009840_abnormal_foam_cell1.40472276
58MP0001348_abnormal_lacrimal_gland1.38797817
59MP0001243_abnormal_dermal_layer1.37639049
60MP0003091_abnormal_cell_migration1.35939148
61MP0008260_abnormal_autophagy1.33794634
62MP0010307_abnormal_tumor_latency1.32867263
63MP0006082_CNS_inflammation1.31082184
64MP0003763_abnormal_thymus_physiology1.30132967
65MP0003183_abnormal_peptide_metabolism1.28865348
66MP0010155_abnormal_intestine_physiology1.26046541
67MP0010030_abnormal_orbit_morphology1.24540409
68MP0000367_abnormal_coat/_hair1.21988154
69MP0009384_cardiac_valve_regurgitation1.19487383
70MP0004858_abnormal_nervous_system1.18947318
71MP0000003_abnormal_adipose_tissue1.18466903
72MP0005310_abnormal_salivary_gland1.18308300
73MP0005666_abnormal_adipose_tissue1.17572947
74MP0000467_abnormal_esophagus_morphology1.16616040
75MP0003172_abnormal_lysosome_physiology1.16108667
76MP0005375_adipose_tissue_phenotype1.15449566
77MP0000465_gastrointestinal_hemorrhage1.15168884
78MP0004272_abnormal_basement_membrane1.14894553
79MP0005464_abnormal_platelet_physiology1.14068735
80MP0002405_respiratory_system_inflammati1.13864655
81MP0005023_abnormal_wound_healing1.13482840
82MP0001533_abnormal_skeleton_physiology1.13117471
83MP0000569_abnormal_digit_pigmentation1.11693914
84MP0005174_abnormal_tail_pigmentation1.11321994
85MP0003448_altered_tumor_morphology1.10659722
86MP0001346_abnormal_lacrimal_gland1.09355482
87MP0009333_abnormal_splenocyte_physiolog1.07605317
88MP0001853_heart_inflammation1.07310253
89MP0005076_abnormal_cell_differentiation1.04331787
90MP0000733_abnormal_muscle_development1.02733138
91MP0000751_myopathy1.00474202
92MP0000013_abnormal_adipose_tissue1.00465807
93MP0001845_abnormal_inflammatory_respons1.00394728
94MP0003045_fibrosis0.98370526
95MP0009780_abnormal_chondrocyte_physiolo0.97039038
96MP0000716_abnormal_immune_system0.96647296
97MP0002398_abnormal_bone_marrow0.95062180
98MP0003279_aneurysm0.95056121
99MP0003724_increased_susceptibility_to0.92511704
100MP0005058_abnormal_lysosome_morphology0.90752420
101MP0003075_altered_response_to0.88026612
102MP0001873_stomach_inflammation0.85451013
103MP0005390_skeleton_phenotype0.84935249
104MP0002089_abnormal_postnatal_growth/wei0.84446326
105MP0002933_joint_inflammation0.82622591
106MP0002095_abnormal_skin_pigmentation0.80131727
107MP0001958_emphysema0.78976533
108MP0005377_hearing/vestibular/ear_phenot0.78576577
109MP0003878_abnormal_ear_physiology0.78576577
110MP0002249_abnormal_larynx_morphology0.77795853
111MP0009053_abnormal_anal_canal0.76595293
112MP0000858_altered_metastatic_potential0.75824492
113MP0002998_abnormal_bone_remodeling0.73157605
114MP0005360_urolithiasis0.73146331
115MP0004185_abnormal_adipocyte_glucose0.73068159
116MP0002722_abnormal_immune_system0.72160030
117MP0009764_decreased_sensitivity_to0.71938554
118MP0001849_ear_inflammation0.71002790
119MP0002429_abnormal_blood_cell0.70918960
120MP0002896_abnormal_bone_mineralization0.70123994
121MP0000627_abnormal_mammary_gland0.69892830
122MP0000767_abnormal_smooth_muscle0.69521390
123MP0003806_abnormal_nucleotide_metabolis0.69391817
124MP0000750_abnormal_muscle_regeneration0.69208864
125MP0000537_abnormal_urethra_morphology0.69157210
126MP0002332_abnormal_exercise_endurance0.68398713
127MP0005367_renal/urinary_system_phenotyp0.67841103
128MP0000516_abnormal_urinary_system0.67841103
129MP0004782_abnormal_surfactant_physiolog0.67585213
130MP0005670_abnormal_white_adipose0.67517143
131MP0005451_abnormal_body_composition0.65685684
132MP0000689_abnormal_spleen_morphology0.64979199
133MP0008469_abnormal_protein_level0.62834478
134MP0004808_abnormal_hematopoietic_stem0.62786272
135MP0008438_abnormal_cutaneous_collagen0.62414219
136MP0001765_abnormal_ion_homeostasis0.61893757
137MP0005508_abnormal_skeleton_morphology0.61420643
138MP0005257_abnormal_intraocular_pressure0.60725215

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.44887413
2Eczematoid dermatitis (HP:0000976)5.35969025
3Plantar hyperkeratosis (HP:0007556)5.20462718
4Palmoplantar hyperkeratosis (HP:0000972)5.12167512
5Palmar hyperkeratosis (HP:0010765)4.77060814
6Thick nail (HP:0001805)4.61964738
7Conjunctival hamartoma (HP:0100780)4.59365301
8Milia (HP:0001056)4.49737339
9Hypotrichosis (HP:0001006)4.42514569
10Woolly hair (HP:0002224)4.27750908
11Onycholysis (HP:0001806)3.98604170
12Erythema (HP:0010783)3.90004236
13Recurrent bacterial skin infections (HP:0005406)3.80239701
14Recurrent abscess formation (HP:0002722)3.77637055
15Erythroderma (HP:0001019)3.75449717
16Congenital ichthyosiform erythroderma (HP:0007431)3.72961435
17Right ventricular cardiomyopathy (HP:0011663)3.72177760
18Lip pit (HP:0100267)3.57925952
19Abnormality of nail color (HP:0100643)3.44844883
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39969351
21Elevated erythrocyte sedimentation rate (HP:0003565)3.37091095
22Broad face (HP:0000283)3.28282451
23Cervical subluxation (HP:0003308)3.24076235
24Hamartoma of the eye (HP:0010568)3.22781164
25Thin bony cortex (HP:0002753)3.21419929
26Hypergammaglobulinemia (HP:0010702)3.15060049
27Fragile nails (HP:0001808)3.08020830
28J-shaped sella turcica (HP:0002680)3.06762353
29Parakeratosis (HP:0001036)3.03350684
30Fragile skin (HP:0001030)3.02861876
31Chronic otitis media (HP:0000389)2.98441459
32Increased cerebral lipofuscin (HP:0011813)2.97542184
33Abnormal blistering of the skin (HP:0008066)2.96634040
34Gangrene (HP:0100758)2.88059109
35Nasal polyposis (HP:0100582)2.86981637
36Pili torti (HP:0003777)2.81115393
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.81082351
38Interstitial pulmonary disease (HP:0006530)2.80403659
39Ectropion (HP:0000656)2.76735658
40Hematochezia (HP:0002573)2.76089803
41Obstructive sleep apnea (HP:0002870)2.75740306
42Mediastinal lymphadenopathy (HP:0100721)2.73395804
43Myositis (HP:0100614)2.71266332
44Orchitis (HP:0100796)2.68324456
45Premature rupture of membranes (HP:0001788)2.65896720
46Recurrent fungal infections (HP:0002841)2.65493737
47Increased connective tissue (HP:0009025)2.64268543
48Gingivitis (HP:0000230)2.62707236
49Atrophic scars (HP:0001075)2.60008114
50Pustule (HP:0200039)2.59977578
51Oral leukoplakia (HP:0002745)2.55110551
52Abnormality of macrophages (HP:0004311)2.53811552
53Dysostosis multiplex (HP:0000943)2.52761909
54Nail dystrophy (HP:0008404)2.51062958
55Hyperacusis (HP:0010780)2.50094807
56Autoimmune thrombocytopenia (HP:0001973)2.47018504
57Abnormality of the distal phalanges of the toes (HP:0010182)2.46823847
58Periodontitis (HP:0000704)2.46366213
59Malnutrition (HP:0004395)2.45539624
60Skin ulcer (HP:0200042)2.42687911
61Flat acetabular roof (HP:0003180)2.40898342
62Axonal loss (HP:0003447)2.40461404
63Acanthosis nigricans (HP:0000956)2.37349555
64Recurrent viral infections (HP:0004429)2.36755829
65Distal upper limb amyotrophy (HP:0007149)2.36553005
66Upper limb amyotrophy (HP:0009129)2.36553005
67Abnormality of the nasal mucosa (HP:0000433)2.36094661
68Nuclear cataract (HP:0100018)2.34862179
69Stomatitis (HP:0010280)2.34588336
70Abnormality of the salivary glands (HP:0010286)2.33640892
71Hyporeflexia of lower limbs (HP:0002600)2.33399431
72Recurrent gram-negative bacterial infections (HP:0005420)2.31447496
73Ridged nail (HP:0001807)2.26324889
74Achilles tendon contracture (HP:0001771)2.25767118
75Difficulty climbing stairs (HP:0003551)2.25121454
76Recurrent skin infections (HP:0001581)2.24439563
77Short nail (HP:0001799)2.22602491
78Selective tooth agenesis (HP:0001592)2.22008811
79Pruritus (HP:0000989)2.21840621
80Ulnar bowing (HP:0003031)2.21802804
81Cerebral aneurysm (HP:0004944)2.20536226
82Cellulitis (HP:0100658)2.20486665
83Mildly elevated creatine phosphokinase (HP:0008180)2.17307825
84Urinary glycosaminoglycan excretion (HP:0003541)2.16200009
85Mucopolysacchariduria (HP:0008155)2.16200009
86Abnormality of the fingertips (HP:0001211)2.14895277
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12657275
88Abnormality of polysaccharide metabolism (HP:0011012)2.12657275
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12657275
90Urticaria (HP:0001025)2.12309863
91Optic neuritis (HP:0100653)2.11908244
92Retrobulbar optic neuritis (HP:0100654)2.11908244
93Vasculitis (HP:0002633)2.11820910
94Sepsis (HP:0100806)2.10846440
95Sparse eyelashes (HP:0000653)2.09814207
96Alopecia of scalp (HP:0002293)2.08657413
97Protrusio acetabuli (HP:0003179)2.07867068
98Oligodontia (HP:0000677)2.04813565
99Stridor (HP:0010307)2.03313579
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.02337935
101Osteolytic defects of the hand bones (HP:0009699)2.02337935
102Ventricular tachycardia (HP:0004756)2.01452701
103Sparse scalp hair (HP:0002209)2.00169397
104Hypohidrosis (HP:0000966)1.99542684
105Corneal erosion (HP:0200020)1.99496474
106Fatigable weakness (HP:0003473)1.98018638
107Abnormality of the neuromuscular junction (HP:0003398)1.98018638
108Obstructive lung disease (HP:0006536)1.97773231
109Chronic obstructive pulmonary disease (HP:0006510)1.97773231
110Abnormality of the Achilles tendon (HP:0005109)1.97229799
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95630459
112Curly hair (HP:0002212)1.94451066
113Cheilitis (HP:0100825)1.93637100
114Pterygium (HP:0001059)1.92911539
115Autoimmune hemolytic anemia (HP:0001890)1.91787128
116Recurrent bronchitis (HP:0002837)1.91548624
117Abnormal hair laboratory examination (HP:0003328)1.90558090
118Joint stiffness (HP:0001387)1.89011214
119Distal lower limb muscle weakness (HP:0009053)1.88903202
120Verrucae (HP:0200043)1.87994840
121Papilloma (HP:0012740)1.87994840
122Abnormality of glycolipid metabolism (HP:0010969)1.87404292
123Abnormality of liposaccharide metabolism (HP:0010968)1.87404292
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.87404292
125Thyroiditis (HP:0100646)1.87006431
126Emphysema (HP:0002097)1.86779258
127Aplasia cutis congenita (HP:0001057)1.85740638
128Disinhibition (HP:0000734)1.85544877
129Elbow flexion contracture (HP:0002987)1.85107384
130Palmoplantar keratoderma (HP:0000982)1.84831599
131Hyperparathyroidism (HP:0000843)1.84233735
132Ureteral obstruction (HP:0006000)1.84138372
133Deformed sella turcica (HP:0002681)1.83862094
134Vertebral compression fractures (HP:0002953)1.83426021
135Arterial thrombosis (HP:0004420)1.81590519
136Distal lower limb amyotrophy (HP:0008944)1.80428931
137Long palpebral fissure (HP:0000637)1.80242637
138Advanced eruption of teeth (HP:0006288)1.80166845
139Pulmonary infiltrates (HP:0002113)1.77104734
140Asymmetry of the thorax (HP:0001555)1.76806751
141Natal tooth (HP:0000695)1.76542096
142Abnormality of the gastric mucosa (HP:0004295)1.76365357
143Aortic regurgitation (HP:0001659)1.74572194
144Loss of speech (HP:0002371)1.73363572
145Trismus (HP:0000211)1.71412425
146Follicular hyperkeratosis (HP:0007502)1.71099777
147Neonatal death (HP:0003811)1.70636184
148Hypoplasia of dental enamel (HP:0006297)1.70453020
149Basal ganglia calcification (HP:0002135)1.70107465
150Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.69144886
151Frequent falls (HP:0002359)1.68352655
152Vacuolated lymphocytes (HP:0001922)1.68186906
153Osteomyelitis (HP:0002754)1.67690533
154Abnormality of oral frenula (HP:0000190)1.67547063
155Chronic mucocutaneous candidiasis (HP:0002728)1.65454232
156Recurrent cutaneous fungal infections (HP:0011370)1.65454232
157Spinal rigidity (HP:0003306)1.64787795
158Blepharitis (HP:0000498)1.63880897
159Abnormality of the thoracic spine (HP:0100711)1.62863962
160Squamous cell carcinoma (HP:0002860)1.62717586
161Tibial bowing (HP:0002982)1.61912754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.67792274
2FRK3.42202550
3MAP3K62.96126464
4ERN12.93630975
5MAP3K142.88591020
6IKBKE2.78571047
7MAP4K12.77068417
8TBK12.74011752
9BLK2.71115296
10TYK22.68783034
11FGFR22.48139261
12MST1R2.33620420
13RIPK42.21031575
14FGFR32.15636012
15IKBKB2.02134782
16KIT1.98566320
17EPHB11.89848935
18TTN1.87860880
19JAK31.85642844
20MET1.82918206
21EEF2K1.72675170
22MAPKAPK31.72007055
23SMG11.68396693
24PTK61.64787933
25JAK11.61105385
26TRPM71.57879006
27FGFR41.54503178
28IRAK31.52998607
29PIM21.49203274
30CHUK1.42768327
31IRAK41.42282762
32FER1.40265868
33MST41.40249701
34ICK1.37985226
35DDR21.34391729
36MAP3K21.33568675
37HCK1.31775012
38PIK3CG1.30199235
39PRKD31.28212129
40PRKD21.27316616
41EPHA31.26974595
42MAP3K31.25061484
43MAP3K131.24757259
44PAK41.24101559
45ARAF1.23938833
46CDC42BPA1.19364231
47FES1.19051807
48LRRK21.17314500
49MAP3K101.11695839
50LATS21.09142946
51RIPK11.08958370
52TRIB31.08786752
53PDGFRA1.08565390
54CSK1.08162275
55PRPF4B1.07555193
56TAOK21.07301364
57TXK1.06661688
58SYK1.06430220
59STK101.05734580
60TAOK31.05402619
61MAP3K11.04604611
62LCK1.02165756
63RPS6KA20.99593972
64MAP2K60.97971276
65SIK30.97955767
66LMTK20.96036057
67HIPK20.95238138
68BTK0.92164788
69NME10.91926312
70ZAP700.91669992
71RPS6KB20.91571141
72TESK10.91365917
73MARK20.91131047
74ITK0.91073677
75DYRK1B0.90886198
76TESK20.89351378
77STK380.89314096
78CDK120.87832749
79MATK0.87027599
80SIK20.81435501
81MTOR0.80827052
82BMX0.80807951
83RPS6KA40.80689280
84PKN20.78181559
85PRKCI0.77523216
86MAP3K110.74029616
87MOS0.72757761
88GRK60.71944528
89LYN0.68294778
90IRAK10.67590054
91MAP3K90.65659601
92PIM10.64853041
93MAPKAPK20.64279104
94STK240.63651446
95DMPK0.63354390
96EPHA20.63344193
97FLT30.63321665
98IRAK20.60620847
99CSF1R0.60043430
100JAK20.59927067
101MAPKAPK50.59848590
102TAOK10.56791133
103TNK20.56617086
104ILK0.55987239
105EPHB20.55842693
106PBK0.54970899
107CAMK1D0.54936163
108PKN10.53435219
109RPS6KA60.51741015
110MAP3K70.51224374
111LATS10.51146720
112TGFBR20.50997092
113LIMK10.49551084
114RPS6KL10.49194274
115RPS6KC10.49194274
116STK40.48423126
117GRK70.47951306
118PDPK10.46347062
119ABL20.46101641
120CDK60.44829630
121MUSK0.41443158
122SIK10.41105736
123NME20.40620949
124STK30.40231700
125TEC0.39696681
126PTK20.39533904
127PDGFRB0.39506985
128ABL10.38904508
129RPS6KA50.37601088
130EGFR0.36202704
131NLK0.36159769
132YES10.36036714
133CAMK1G0.35299046
134MAP2K30.34933068
135STK110.34904205
136PRKD10.34630795
137CLK10.34123887
138MAP2K20.34113153
139NTRK10.31964217
140FGFR10.26055863
141CDK70.24651739
142FGR0.24337262
143MAPK70.23932354
144CDK40.22491522
145WNK40.21820391

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.37260819
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23690817
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12808737
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.10062177
5Osteoclast differentiation_Homo sapiens_hsa043802.03015191
6NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87576394
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82829704
8TNF signaling pathway_Homo sapiens_hsa046681.79242872
9B cell receptor signaling pathway_Homo sapiens_hsa046621.78552832
10Staphylococcus aureus infection_Homo sapiens_hsa051501.77393767
11Toxoplasmosis_Homo sapiens_hsa051451.76452891
12Measles_Homo sapiens_hsa051621.74889039
13Fructose and mannose metabolism_Homo sapiens_hsa000511.74534266
14Influenza A_Homo sapiens_hsa051641.68943669
15Pertussis_Homo sapiens_hsa051331.65687208
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63973815
17Graft-versus-host disease_Homo sapiens_hsa053321.62287972
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61350761
19Tuberculosis_Homo sapiens_hsa051521.56843674
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56088534
21Legionellosis_Homo sapiens_hsa051341.48114915
22Herpes simplex infection_Homo sapiens_hsa051681.45667724
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44671034
24Antigen processing and presentation_Homo sapiens_hsa046121.43232367
25Malaria_Homo sapiens_hsa051441.42018939
26Acute myeloid leukemia_Homo sapiens_hsa052211.39678708
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.39600852
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.37108675
29Hepatitis C_Homo sapiens_hsa051601.32951098
30Rheumatoid arthritis_Homo sapiens_hsa053231.32816747
31Primary immunodeficiency_Homo sapiens_hsa053401.32484890
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32300861
33Hematopoietic cell lineage_Homo sapiens_hsa046401.32052112
34Apoptosis_Homo sapiens_hsa042101.30964998
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.30415805
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28376132
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.26170483
38Salmonella infection_Homo sapiens_hsa051321.25822579
39Allograft rejection_Homo sapiens_hsa053301.24890102
40Chemokine signaling pathway_Homo sapiens_hsa040621.24454050
41Sphingolipid metabolism_Homo sapiens_hsa006001.24152066
42Shigellosis_Homo sapiens_hsa051311.19977637
43T cell receptor signaling pathway_Homo sapiens_hsa046601.19323111
44Lysosome_Homo sapiens_hsa041421.17862476
45Chronic myeloid leukemia_Homo sapiens_hsa052201.15025726
46Galactose metabolism_Homo sapiens_hsa000521.12410167
47Asthma_Homo sapiens_hsa053101.12235089
48Hepatitis B_Homo sapiens_hsa051611.11440339
49Prion diseases_Homo sapiens_hsa050201.10366828
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10346205
51VEGF signaling pathway_Homo sapiens_hsa043701.09077380
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08211684
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.05871075
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04327014
55Other glycan degradation_Homo sapiens_hsa005111.03744469
56Small cell lung cancer_Homo sapiens_hsa052221.03573443
57Platelet activation_Homo sapiens_hsa046111.00794677
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00492329
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99902106
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99551726
61Insulin signaling pathway_Homo sapiens_hsa049100.97992091
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.97429000
63Amoebiasis_Homo sapiens_hsa051460.96203264
64Pancreatic cancer_Homo sapiens_hsa052120.93839800
65Axon guidance_Homo sapiens_hsa043600.93214886
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92975124
67Proteoglycans in cancer_Homo sapiens_hsa052050.92571774
68Notch signaling pathway_Homo sapiens_hsa043300.91864305
69Viral myocarditis_Homo sapiens_hsa054160.91029830
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89696784
71MicroRNAs in cancer_Homo sapiens_hsa052060.89409024
72Dorso-ventral axis formation_Homo sapiens_hsa043200.88271942
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.86003410
74Vibrio cholerae infection_Homo sapiens_hsa051100.85738107
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85224066
76Thyroid cancer_Homo sapiens_hsa052160.85006469
77African trypanosomiasis_Homo sapiens_hsa051430.84774525
78Prolactin signaling pathway_Homo sapiens_hsa049170.83372531
79p53 signaling pathway_Homo sapiens_hsa041150.81555644
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.80996950
81Phagosome_Homo sapiens_hsa041450.79943167
82Mineral absorption_Homo sapiens_hsa049780.79937601
83Linoleic acid metabolism_Homo sapiens_hsa005910.78694588
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78487038
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77620850
86Bladder cancer_Homo sapiens_hsa052190.76045515
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75900160
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.75199627
89ErbB signaling pathway_Homo sapiens_hsa040120.73462095
90Adherens junction_Homo sapiens_hsa045200.73224877
91Sulfur relay system_Homo sapiens_hsa041220.72437405
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71998829
93Insulin resistance_Homo sapiens_hsa049310.70182983
94Endometrial cancer_Homo sapiens_hsa052130.69675834
95Choline metabolism in cancer_Homo sapiens_hsa052310.67353153
96Type II diabetes mellitus_Homo sapiens_hsa049300.64839545
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64593618
98Prostate cancer_Homo sapiens_hsa052150.64300709
99Inositol phosphate metabolism_Homo sapiens_hsa005620.63665307
100Renal cell carcinoma_Homo sapiens_hsa052110.63608886
101Focal adhesion_Homo sapiens_hsa045100.63244809
102Arachidonic acid metabolism_Homo sapiens_hsa005900.63088578
103Estrogen signaling pathway_Homo sapiens_hsa049150.63079104
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62649425
105Glioma_Homo sapiens_hsa052140.62614798
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61997768
107Pentose phosphate pathway_Homo sapiens_hsa000300.61545654
108Caffeine metabolism_Homo sapiens_hsa002320.60968584
109Pathways in cancer_Homo sapiens_hsa052000.59538307
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.58665147
111Non-small cell lung cancer_Homo sapiens_hsa052230.58543536
112Endocytosis_Homo sapiens_hsa041440.57576985
113ECM-receptor interaction_Homo sapiens_hsa045120.54048428
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53835436
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53489057
116Ras signaling pathway_Homo sapiens_hsa040140.53121360
117Tight junction_Homo sapiens_hsa045300.52565436
118Melanoma_Homo sapiens_hsa052180.52528772
119Dilated cardiomyopathy_Homo sapiens_hsa054140.52315009
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.52209521
121AMPK signaling pathway_Homo sapiens_hsa041520.51712356
122Viral carcinogenesis_Homo sapiens_hsa052030.51549099
123MAPK signaling pathway_Homo sapiens_hsa040100.51318142
124GnRH signaling pathway_Homo sapiens_hsa049120.50852491
125mTOR signaling pathway_Homo sapiens_hsa041500.50674557
126HTLV-I infection_Homo sapiens_hsa051660.49743160
127Rap1 signaling pathway_Homo sapiens_hsa040150.49727518
128HIF-1 signaling pathway_Homo sapiens_hsa040660.49606820
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48900812

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