PLET1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)9.73819317
2negative regulation of cytosolic calcium ion concentration (GO:0051481)8.12588452
3pyrimidine dimer repair (GO:0006290)8.01998310
4negative regulation of cAMP-mediated signaling (GO:0043951)7.11732821
5mannosylation (GO:0097502)6.78884157
6signal complex assembly (GO:0007172)6.38809508
7opioid receptor signaling pathway (GO:0038003)6.34773049
8behavioral response to ethanol (GO:0048149)5.91938077
9preassembly of GPI anchor in ER membrane (GO:0016254)5.86017528
10production of molecular mediator involved in inflammatory response (GO:0002532)5.52180188
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.28169950
12regulation of mitotic spindle checkpoint (GO:1903504)5.28169950
13skin morphogenesis (GO:0043589)5.22262444
14nucleotide transmembrane transport (GO:1901679)5.15010781
15adaptation of signaling pathway (GO:0023058)5.14170142
16GPI anchor metabolic process (GO:0006505)4.76948044
17regulation of DNA damage checkpoint (GO:2000001)4.73502198
18positive regulation of oligodendrocyte differentiation (GO:0048714)4.70187952
19hemidesmosome assembly (GO:0031581)4.69477821
20GPI anchor biosynthetic process (GO:0006506)4.62787043
21cellular response to ATP (GO:0071318)4.61045742
22regulation of water loss via skin (GO:0033561)4.46388408
23branching involved in labyrinthine layer morphogenesis (GO:0060670)4.45185522
24kynurenine metabolic process (GO:0070189)4.44425428
25bundle of His cell to Purkinje myocyte communication (GO:0086069)4.29474796
26mitotic cell cycle arrest (GO:0071850)4.28626059
27neural tube formation (GO:0001841)4.25111300
28lung lobe morphogenesis (GO:0060463)4.19649878
29desmosome organization (GO:0002934)4.14516095
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.04480680
31adult feeding behavior (GO:0008343)3.97414453
32phosphorelay signal transduction system (GO:0000160)3.97125826
33adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.85866383
34negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.85756617
35establishment of skin barrier (GO:0061436)3.84815601
36positive regulation of cholesterol efflux (GO:0010875)3.83721612
37multicellular organism reproduction (GO:0032504)3.82461366
38positive regulation of T cell cytokine production (GO:0002726)3.82368361
39tolerance induction (GO:0002507)3.80216202
40peptidyl-threonine dephosphorylation (GO:0035970)3.77930703
41negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.76685542
42ether lipid metabolic process (GO:0046485)3.74790022
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70880907
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.70880907
45modulation by symbiont of host immune response (GO:0052553)3.70880907
46positive regulation by symbiont of host defense response (GO:0052509)3.70880907
47modulation by symbiont of host defense response (GO:0052031)3.70880907
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70880907
49decidualization (GO:0046697)3.68717299
50positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.66077156
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63166194
52apoptotic cell clearance (GO:0043277)3.60772445
53proline transport (GO:0015824)3.58540243
54response to lipoprotein particle (GO:0055094)3.57699669
55regulation of acrosome reaction (GO:0060046)3.56444444
56white fat cell differentiation (GO:0050872)3.56396220
57regulation of protein glycosylation (GO:0060049)3.55555731
58C-terminal protein lipidation (GO:0006501)3.55408359
59hepatocyte apoptotic process (GO:0097284)3.54966034
60keratinocyte development (GO:0003334)3.53794195
61low-density lipoprotein particle clearance (GO:0034383)3.48767701
62lung vasculature development (GO:0060426)3.48082801
63growth hormone receptor signaling pathway (GO:0060396)3.45895673
64diterpenoid biosynthetic process (GO:0016102)3.43930145
65positive regulation of chemokine biosynthetic process (GO:0045080)3.43567853
66glycolipid biosynthetic process (GO:0009247)3.43502757
67positive regulation of cAMP-mediated signaling (GO:0043950)3.42522255
68regulation of cell cycle checkpoint (GO:1901976)3.41505378
69cell adhesion mediated by integrin (GO:0033627)3.40653012
70mesodermal cell differentiation (GO:0048333)3.39802211
71detection of light stimulus involved in visual perception (GO:0050908)3.37724684
72detection of light stimulus involved in sensory perception (GO:0050962)3.37724684
73single strand break repair (GO:0000012)3.37298888
74piRNA metabolic process (GO:0034587)3.36574648
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34428895
76macrophage activation involved in immune response (GO:0002281)3.33815506
77cytokine secretion (GO:0050663)3.32844884
78DNA synthesis involved in DNA repair (GO:0000731)3.30301148
79cell differentiation involved in embryonic placenta development (GO:0060706)3.29286163
80mammary gland epithelial cell differentiation (GO:0060644)3.28508137
81positive regulation of cholesterol transport (GO:0032376)3.28501805
82positive regulation of sterol transport (GO:0032373)3.28501805
83hypotonic response (GO:0006971)3.28262972
84regulation of podosome assembly (GO:0071801)3.28121774
85endoderm formation (GO:0001706)3.23087302
86regulation of translational termination (GO:0006449)3.22042362
87sphingoid metabolic process (GO:0046519)3.21582938
88response to protozoan (GO:0001562)3.19618392
89intestinal epithelial cell development (GO:0060576)3.19584438
90neutrophil activation involved in immune response (GO:0002283)3.18800327
91positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17324900
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15456841
93response to host immune response (GO:0052572)3.15456841
94maintenance of gastrointestinal epithelium (GO:0030277)3.15218767
95phospholipid scrambling (GO:0017121)3.14958636
96positive regulation of astrocyte differentiation (GO:0048711)3.12610141
97negative regulation of acute inflammatory response (GO:0002674)3.11841072
98multicellular organismal water homeostasis (GO:0050891)3.11405844
99diol metabolic process (GO:0034311)3.11350863
100positive regulation of macrophage cytokine production (GO:0060907)3.06400028
101response to progesterone (GO:0032570)3.06294580
102telomere maintenance via telomerase (GO:0007004)3.05854653
103positive regulation of glycolytic process (GO:0045821)3.05562064
104regulation of spindle checkpoint (GO:0090231)3.04576847
105positive regulation of toll-like receptor signaling pathway (GO:0034123)3.04370588
106establishment of endothelial barrier (GO:0061028)3.03692951
107JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03377215
108hydrogen peroxide biosynthetic process (GO:0050665)3.03072342
109histone H3-K9 modification (GO:0061647)3.02869608
110regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02511078
111regulation of T cell cytokine production (GO:0002724)3.01103196
112response to host defenses (GO:0052200)3.00955146
113response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00955146
114response to host (GO:0075136)3.00955146
115termination of G-protein coupled receptor signaling pathway (GO:0038032)2.99492089
116* wound healing, spreading of epidermal cells (GO:0035313)2.99062881
117positive regulation of type 2 immune response (GO:0002830)2.97755857
118facial nerve structural organization (GO:0021612)2.97209822
119positive regulation of actin filament depolymerization (GO:0030836)2.95495201
120detection of molecule of bacterial origin (GO:0032490)2.94839133
121regulation of T cell tolerance induction (GO:0002664)2.94031415
122ovulation from ovarian follicle (GO:0001542)2.93684961
123cellular response to growth hormone stimulus (GO:0071378)2.92474108
124negative regulation of glycoprotein biosynthetic process (GO:0010561)2.92236514
125positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.92046619
126regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.92046619
127regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.90910402
128branching involved in salivary gland morphogenesis (GO:0060445)2.90677447
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90578289
130C-terminal protein amino acid modification (GO:0018410)2.89550814
131positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.89289150
132adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.88872385
133keratinization (GO:0031424)2.87157606
134positive regulation of hair cycle (GO:0042635)2.86727609
135positive regulation of hair follicle development (GO:0051798)2.86727609
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86118102
137trophectodermal cell differentiation (GO:0001829)2.85821850
138histone H3-K9 methylation (GO:0051567)2.85482738
139mammary gland epithelial cell proliferation (GO:0033598)2.85355182
140negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.84632677
141superoxide anion generation (GO:0042554)2.84241030
142response to peptidoglycan (GO:0032494)2.84136152
143trophoblast giant cell differentiation (GO:0060707)2.83911001
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83128886
145negative regulation of lipid storage (GO:0010888)2.82504776
146tumor necrosis factor-mediated signaling pathway (GO:0033209)2.81012138
147regulation of acyl-CoA biosynthetic process (GO:0050812)2.80142807
148muscle organ morphogenesis (GO:0048644)2.79749417
149positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79269533
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78255638
151protein K11-linked deubiquitination (GO:0035871)2.77660713
152positive regulation of p38MAPK cascade (GO:1900745)2.76982901
153granulocyte activation (GO:0036230)2.76937221
154regulation of chemokine biosynthetic process (GO:0045073)2.76860622
155centriole replication (GO:0007099)2.76684591
156peristalsis (GO:0030432)2.76304266
157genitalia morphogenesis (GO:0035112)2.76257195
158replication fork processing (GO:0031297)2.76004591
159negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75527588
160negative regulation of interleukin-1 production (GO:0032692)2.75157142
161positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.74798650
162regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74095418
163negative regulation of systemic arterial blood pressure (GO:0003085)2.73677156
164cellular response to interferon-alpha (GO:0035457)2.73610671
165gamma-aminobutyric acid transport (GO:0015812)2.73015924
166regulation of bile acid biosynthetic process (GO:0070857)2.72586228
167DNA deamination (GO:0045006)2.71100456
168negative regulation of fatty acid biosynthetic process (GO:0045717)2.70722928
169behavioral response to nicotine (GO:0035095)2.70418576
170water homeostasis (GO:0030104)2.70414042
171positive regulation of T cell differentiation in thymus (GO:0033089)2.69693195
172photoreceptor cell maintenance (GO:0045494)2.69204825
173positive regulation of pseudopodium assembly (GO:0031274)2.68955765
174keratinocyte differentiation (GO:0030216)2.68322465
175somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67924903
176somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67924903
177isotype switching (GO:0045190)2.67924903
178regulation of chromatin silencing (GO:0031935)2.67886736
179termination of signal transduction (GO:0023021)2.67219581
180negative regulation of smooth muscle cell migration (GO:0014912)2.66585618
181regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66129029
182positive regulation of interferon-alpha production (GO:0032727)2.66044701
183regulation of chemokine secretion (GO:0090196)2.65599732
184phasic smooth muscle contraction (GO:0014821)2.64636683
185positive regulation of transcription factor import into nucleus (GO:0042993)2.63474700
186glycine transport (GO:0015816)2.62889558
187hepatocyte differentiation (GO:0070365)2.62492605
188regulation of macrophage cytokine production (GO:0010935)2.62076912
189positive regulation of macrophage differentiation (GO:0045651)2.61920541
190positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61471102
191progesterone metabolic process (GO:0042448)2.60874263
192positive regulation of leukocyte degranulation (GO:0043302)2.60760408
193epithelial structure maintenance (GO:0010669)2.60715287
194regulation of cAMP-mediated signaling (GO:0043949)2.59338545
195regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56728364
196reactive oxygen species biosynthetic process (GO:1903409)2.56097849
197positive regulation of actin cytoskeleton reorganization (GO:2000251)2.55687408
198neutrophil activation (GO:0042119)2.55590643
199regulation of heterotypic cell-cell adhesion (GO:0034114)2.53325988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.68089082
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.61799109
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.75815786
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.66675339
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.39737000
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.33594743
7VDR_22108803_ChIP-Seq_LS180_Human3.15337588
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.04552142
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.04313148
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.04163285
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.03592164
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.96640466
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.95172293
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92493161
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90599094
16TAF15_26573619_Chip-Seq_HEK293_Human2.89767807
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.70765142
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62157705
19GBX2_23144817_ChIP-Seq_PC3_Human2.59524601
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.54584902
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43493699
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40485788
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.29021385
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27750122
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24452990
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24452990
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22636258
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21977414
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.21897385
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20870332
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18230864
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.12201698
33SOX2_20726797_ChIP-Seq_SW620_Human2.12172408
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08775842
35ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08703586
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02094930
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98036804
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96634373
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95568364
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.94507855
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89085067
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87658135
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84944929
44IGF1R_20145208_ChIP-Seq_DFB_Human1.81900207
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80888256
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.80009021
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.78563841
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78219157
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76191240
50CBP_20019798_ChIP-Seq_JUKART_Human1.76191240
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.74705985
52ZNF274_21170338_ChIP-Seq_K562_Hela1.72191960
53GATA4_25053715_ChIP-Seq_YYC3_Human1.72051000
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71511914
55CLOCK_20551151_ChIP-Seq_293T_Human1.67802143
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.66479647
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65547556
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64642226
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64642226
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63533828
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.63054436
62ER_23166858_ChIP-Seq_MCF-7_Human1.62968764
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.61932832
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60912266
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60288493
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59671318
67GATA6_25053715_ChIP-Seq_YYC3_Human1.58819442
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57734367
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57632347
70ZNF263_19887448_ChIP-Seq_K562_Human1.56672328
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56306122
72EZH2_22144423_ChIP-Seq_EOC_Human1.54095779
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53382369
74P300_19829295_ChIP-Seq_ESCs_Human1.52089738
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51766078
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51270858
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50939942
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.50148372
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49891332
80IRF1_19129219_ChIP-ChIP_H3396_Human1.49530986
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49356254
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.47275923
83TP53_22573176_ChIP-Seq_HFKS_Human1.46475179
84CJUN_26792858_Chip-Seq_BT549_Human1.46380772
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46122979
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.45627964
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.44831752
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.43003321
89TCF4_23295773_ChIP-Seq_U87_Human1.42401041
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.41364740
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40536817
92SMAD4_21799915_ChIP-Seq_A2780_Human1.40533003
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40292835
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39125828
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38429766
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36267998
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36053068
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.34766591
99FUS_26573619_Chip-Seq_HEK293_Human1.33886036
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32707205
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.32093492
102GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31575466
103ATF3_27146783_Chip-Seq_COLON_Human1.31025946
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30857925
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30760958
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30026852
107STAT3_23295773_ChIP-Seq_U87_Human1.29657093
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29344855
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28664476
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28370937
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25696079
112KLF5_25053715_ChIP-Seq_YYC3_Human1.25494780
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.24728977
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24201892
115RACK7_27058665_Chip-Seq_MCF-7_Human1.24049004
116GATA1_22025678_ChIP-Seq_K562_Human1.24008370
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23460362
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23031508
119CDX2_22108803_ChIP-Seq_LS180_Human1.23001283
120SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22544620
121VDR_24787735_ChIP-Seq_THP-1_Human1.22518574
122BCAT_22108803_ChIP-Seq_LS180_Human1.22336739
123KDM2B_26808549_Chip-Seq_REH_Human1.19778840
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18775242
125NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18775242
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18154979
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17211346
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16035585
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15666341
130RUNX2_22187159_ChIP-Seq_PCA_Human1.15566726
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14585219
132EGR1_19032775_ChIP-ChIP_M12_Human1.14339205
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12936585
134DROSHA_22980978_ChIP-Seq_HELA_Human1.12202545
135TCF4_22108803_ChIP-Seq_LS180_Human1.10520629
136AHR_22903824_ChIP-Seq_MCF-7_Human1.10339525
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10212985
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09662682
139EWS_26573619_Chip-Seq_HEK293_Human1.08864554
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07499431
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04321137
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04318463
143ELK3_25401928_ChIP-Seq_HUVEC_Human1.04190498
144SMAD4_21741376_ChIP-Seq_HESCs_Human1.04141223
145RNF2_27304074_Chip-Seq_NSC_Mouse1.03791649
146SMAD3_21741376_ChIP-Seq_HESCs_Human1.02819702
147AR_25329375_ChIP-Seq_VCAP_Human1.02018222
148SOX2_21211035_ChIP-Seq_LN229_Gbm1.01964719
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01307915
150GATA3_27048872_Chip-Seq_THYMUS_Human1.00403601
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00215308
152KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00050462
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99824910
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.98652957
155GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98071927
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97980906
157TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97909476
158MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97555279
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.97083750
160TP63_23658742_ChIP-Seq_EP156T_Human0.96558643
161ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95600343
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.95548306
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95446559
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95442845
165PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95433761
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95208844
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94262518
168HOXB7_26014856_ChIP-Seq_BT474_Human0.94038717
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93741625
170NFYB_21822215_ChIP-Seq_K562_Human0.93361778
171NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93274094
172FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93201454
173OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92495159
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92124485
175IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91124925
176DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91037763
177RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90732257
178FOXH1_21741376_ChIP-Seq_EPCs_Human0.90392575
179LXR_22158963_ChIP-Seq_LIVER_Mouse0.88389336
180CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87349689
181RUNX_20019798_ChIP-Seq_JUKART_Human0.87314164
182PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87249528
183TCF4_18268006_ChIP-ChIP_LS174T_Human0.84869696
184VDR_24763502_ChIP-Seq_THP-1_Human0.84768917
185AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81726823
186GATA2_19941826_ChIP-Seq_K562_Human0.81270683
187BRD4_25478319_ChIP-Seq_HGPS_Human0.80757761
188RXR_22158963_ChIP-Seq_LIVER_Mouse0.78476391
189RXR_22108803_ChIP-Seq_LS180_Human0.78252915
190NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78120753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.15203593
2MP0003787_abnormal_imprinting5.08410242
3MP0009780_abnormal_chondrocyte_physiolo4.60186676
4MP0003880_abnormal_central_pattern4.42591126
5MP0002254_reproductive_system_inflammat4.33900519
6MP0002102_abnormal_ear_morphology4.04962526
7MP0010234_abnormal_vibrissa_follicle3.66451224
8MP0002837_dystrophic_cardiac_calcinosis3.62646693
9MP0009278_abnormal_bone_marrow3.59701385
10MP0001881_abnormal_mammary_gland3.32484832
11MP0001968_abnormal_touch/_nociception3.22856694
12MP0004264_abnormal_extraembryonic_tissu3.13173485
13MP0003303_peritoneal_inflammation3.12842187
14MP0005248_abnormal_Harderian_gland2.92731401
15MP0003566_abnormal_cell_adhesion2.82556846
16MP0003436_decreased_susceptibility_to2.74212823
17MP0005670_abnormal_white_adipose2.66099291
18MP0009785_altered_susceptibility_to2.61814019
19MP0003705_abnormal_hypodermis_morpholog2.53952374
20MP0004947_skin_inflammation2.47089129
21MP0006072_abnormal_retinal_apoptosis2.46858767
22MP0005257_abnormal_intraocular_pressure2.41379053
23MP0002796_impaired_skin_barrier2.40480634
24MP0003453_abnormal_keratinocyte_physiol2.40091106
25MP0010352_gastrointestinal_tract_polyps2.38193008
26MP0000569_abnormal_digit_pigmentation2.35701130
27MP0008057_abnormal_DNA_replication2.22980538
28MP0000013_abnormal_adipose_tissue2.22957000
29MP0000627_abnormal_mammary_gland2.19788712
30MP0010678_abnormal_skin_adnexa2.07958013
31MP0003300_gastrointestinal_ulcer2.04012240
32MP0002419_abnormal_innate_immunity2.03115078
33MP0002098_abnormal_vibrissa_morphology2.02686250
34MP0002148_abnormal_hypersensitivity_rea1.99297105
35MP0001545_abnormal_hematopoietic_system1.90513594
36MP0005397_hematopoietic_system_phenotyp1.90513594
37MP0003448_altered_tumor_morphology1.86793953
38MP0001919_abnormal_reproductive_system1.85801491
39MP0001835_abnormal_antigen_presentation1.85458173
40MP0005076_abnormal_cell_differentiation1.84879289
41MP0001216_abnormal_epidermal_layer1.84197153
42MP0001346_abnormal_lacrimal_gland1.84059800
43MP0000383_abnormal_hair_follicle1.82590961
44MP0004272_abnormal_basement_membrane1.82041161
45MP0003724_increased_susceptibility_to1.79396553
46MP0002876_abnormal_thyroid_physiology1.76221066
47MP0004510_myositis1.74995157
48MP0005025_abnormal_response_to1.74674029
49MP0006082_CNS_inflammation1.70166440
50MP0005166_decreased_susceptibility_to1.69717039
51MP0005646_abnormal_pituitary_gland1.69514820
52MP0005000_abnormal_immune_tolerance1.67176610
53MP0005360_urolithiasis1.66567823
54MP0001533_abnormal_skeleton_physiology1.59886152
55MP0005501_abnormal_skin_physiology1.57930798
56MP0003252_abnormal_bile_duct1.55368612
57MP0004782_abnormal_surfactant_physiolog1.52278073
58MP0006035_abnormal_mitochondrial_morpho1.52261121
59MP0000003_abnormal_adipose_tissue1.51385609
60MP0009764_decreased_sensitivity_to1.49949754
61MP0000858_altered_metastatic_potential1.47504860
62MP0002998_abnormal_bone_remodeling1.46553950
63MP0003075_altered_response_to1.44926167
64MP0000377_abnormal_hair_follicle1.41560002
65MP0003121_genomic_imprinting1.38647531
66MP0005551_abnormal_eye_electrophysiolog1.38003482
67MP0010155_abnormal_intestine_physiology1.35491888
68MP0002452_abnormal_antigen_presenting1.35416426
69MP0001501_abnormal_sleep_pattern1.33881455
70MP0009046_muscle_twitch1.33210506
71MP0002971_abnormal_brown_adipose1.32933243
72MP0001851_eye_inflammation1.30880741
73MP0000015_abnormal_ear_pigmentation1.30789604
74MP0003879_abnormal_hair_cell1.30215423
75MP0005389_reproductive_system_phenotype1.29345739
76MP0001853_heart_inflammation1.28513229
77MP0003941_abnormal_skin_development1.26763314
78MP0005275_abnormal_skin_tensile1.26644325
79MP0005023_abnormal_wound_healing1.26071887
80MP0002060_abnormal_skin_morphology1.25356152
81MP0002909_abnormal_adrenal_gland1.23989483
82MP0001486_abnormal_startle_reflex1.22333097
83MP0001502_abnormal_circadian_rhythm1.21020023
84MP0005164_abnormal_response_to1.20449637
85MP0002928_abnormal_bile_duct1.20258719
86MP0002733_abnormal_thermal_nociception1.19997024
87MP0000343_altered_response_to1.19517621
88MP0001845_abnormal_inflammatory_respons1.19229201
89MP0005671_abnormal_response_to1.18795770
90MP0006276_abnormal_autonomic_nervous1.18363437
91MP0001790_abnormal_immune_system1.17057184
92MP0005387_immune_system_phenotype1.17057184
93MP0003045_fibrosis1.16806580
94MP0008004_abnormal_stomach_pH1.16705246
95MP0004130_abnormal_muscle_cell1.15390267
96MP0004142_abnormal_muscle_tone1.13550503
97MP0000579_abnormal_nail_morphology1.12987703
98MP0003763_abnormal_thymus_physiology1.11271557
99MP0002723_abnormal_immune_serum1.09211234
100MP0002006_tumorigenesis1.07776054
101MP0005310_abnormal_salivary_gland1.07019317
102MP0000427_abnormal_hair_cycle1.05360854
103MP0002295_abnormal_pulmonary_circulatio1.03797476
104MP0003866_abnormal_defecation1.03680673
105MP0003186_abnormal_redox_activity1.03528909
106MP0001819_abnormal_immune_cell1.01337663
107MP0010771_integument_phenotype1.01064816
108MP0001849_ear_inflammation1.00952322
109MP0006054_spinal_hemorrhage1.00865859
110MP0009745_abnormal_behavioral_response1.00050423
111MP0000647_abnormal_sebaceous_gland0.99276169
112MP0005464_abnormal_platelet_physiology0.99120354
113MP0009053_abnormal_anal_canal0.98756857
114MP0003959_abnormal_lean_body0.98295869
115MP0002933_joint_inflammation0.97760514
116MP0001986_abnormal_taste_sensitivity0.97433567
117MP0000566_synostosis0.97337507
118MP0005386_behavior/neurological_phenoty0.96626618
119MP0004924_abnormal_behavior0.96626618
120MP0004883_abnormal_blood_vessel0.96100348
121MP0002420_abnormal_adaptive_immunity0.96031836
122MP0005390_skeleton_phenotype0.95301106
123MP0003633_abnormal_nervous_system0.94434696
124MP0002405_respiratory_system_inflammati0.94402472
125MP0004019_abnormal_vitamin_homeostasis0.93855621
126MP0002282_abnormal_trachea_morphology0.93545715
127MP0009333_abnormal_splenocyte_physiolog0.93011240
128MP0009931_abnormal_skin_appearance0.92965569
129MP0004185_abnormal_adipocyte_glucose0.92751180
130MP0005167_abnormal_blood-brain_barrier0.92248854
131MP0003936_abnormal_reproductive_system0.90877231
132MP0004084_abnormal_cardiac_muscle0.90392505
133MP0003795_abnormal_bone_structure0.90138415
134MP0008872_abnormal_physiological_respon0.88505488
135MP0003828_pulmonary_edema0.88210932
136MP0000685_abnormal_immune_system0.87750260
137MP0003091_abnormal_cell_migration0.87032132
138MP0002067_abnormal_sensory_capabilities0.86785934
139MP0005058_abnormal_lysosome_morphology0.86649390
140MP0008469_abnormal_protein_level0.86315196
141MP0000516_abnormal_urinary_system0.85873343
142MP0005367_renal/urinary_system_phenotyp0.85873343
143MP0001800_abnormal_humoral_immune0.82688964
144MP0003950_abnormal_plasma_membrane0.82216668
145MP0003191_abnormal_cellular_cholesterol0.81687756
146MP0001191_abnormal_skin_condition0.81189381
147MP0008775_abnormal_heart_ventricle0.80738917
148MP0003195_calcinosis0.80278467
149MP0002136_abnormal_kidney_physiology0.80122609
150MP0005253_abnormal_eye_physiology0.78595311
151MP0000465_gastrointestinal_hemorrhage0.78205653
152MP0002638_abnormal_pupillary_reflex0.75969141
153MP0000249_abnormal_blood_vessel0.75851400
154MP0001663_abnormal_digestive_system0.75771820
155MP0002108_abnormal_muscle_morphology0.74661875
156MP0002896_abnormal_bone_mineralization0.74617864
157MP0002693_abnormal_pancreas_physiology0.74359372
158MP0005645_abnormal_hypothalamus_physiol0.72867641
159MP0000367_abnormal_coat/_hair0.71041967
160MP0002272_abnormal_nervous_system0.70329801
161MP0000762_abnormal_tongue_morphology0.69988724
162MP0005647_abnormal_sex_gland0.69471309
163MP0001944_abnormal_pancreas_morphology0.69019305
164MP0005334_abnormal_fat_pad0.68278177
165MP0002735_abnormal_chemical_nociception0.65440751
166MP0005503_abnormal_tendon_morphology0.64387437
167MP0000749_muscle_degeneration0.63369831
168MP0002095_abnormal_skin_pigmentation0.62025487
169MP0000778_abnormal_nervous_system0.60907508
170MP0005452_abnormal_adipose_tissue0.59438070
171MP0002557_abnormal_social/conspecific_i0.58282957
172MP0002736_abnormal_nociception_after0.55533919
173MP0004215_abnormal_myocardial_fiber0.55054223
174MP0001905_abnormal_dopamine_level0.54108368
175MP0002751_abnormal_autonomic_nervous0.52195771
176MP0009765_abnormal_xenobiotic_induced0.51684950
177MP0002063_abnormal_learning/memory/cond0.51678496
178MP0002396_abnormal_hematopoietic_system0.51078750
179MP0001324_abnormal_eye_pigmentation0.50947524
180MP0000230_abnormal_systemic_arterial0.50924751
181MP0002078_abnormal_glucose_homeostasis0.50428924
182MP0004036_abnormal_muscle_relaxation0.50381662
183MP0004043_abnormal_pH_regulation0.48647872

Predicted human phenotypes

RankGene SetZ-score
1Large eyes (HP:0001090)7.13262127
2Right ventricular cardiomyopathy (HP:0011663)5.88751829
3Tented upper lip vermilion (HP:0010804)5.74612763
4Anteriorly placed anus (HP:0001545)5.62736665
5Eczematoid dermatitis (HP:0000976)5.38604557
6Chromsome breakage (HP:0040012)5.30559941
7Thyroid-stimulating hormone excess (HP:0002925)5.20092066
8Pili torti (HP:0003777)5.00492892
9Onycholysis (HP:0001806)4.78804139
10Gaze-evoked nystagmus (HP:0000640)4.63702650
11Episodic fever (HP:0001954)4.29269574
12Milia (HP:0001056)4.24348269
13Interstitial pulmonary disease (HP:0006530)4.20872472
14Recurrent bacterial skin infections (HP:0005406)4.09064324
15Absent speech (HP:0001344)4.04895020
16Recurrent gram-negative bacterial infections (HP:0005420)3.92575743
17Recurrent abscess formation (HP:0002722)3.91833846
18Abnormality of cochlea (HP:0000375)3.85368665
19Fragile nails (HP:0001808)3.72933254
20Poikiloderma (HP:0001029)3.69463228
21Atrophic scars (HP:0001075)3.54251340
22Micronodular cirrhosis (HP:0001413)3.47892122
23Plantar hyperkeratosis (HP:0007556)3.40471872
24Abnormality of macrophages (HP:0004311)3.33426509
25Vacuolated lymphocytes (HP:0001922)3.32931397
26Congenital ichthyosiform erythroderma (HP:0007431)3.29890234
27Poor speech (HP:0002465)3.29088675
28Nonprogressive disorder (HP:0003680)3.29084147
29Curly hair (HP:0002212)3.25359953
30Intestinal atresia (HP:0011100)3.22534214
31Humeroradial synostosis (HP:0003041)3.15892845
32Synostosis involving the elbow (HP:0003938)3.15892845
33Thick nail (HP:0001805)3.09555966
34IgG deficiency (HP:0004315)3.04444866
35Abnormality of proline metabolism (HP:0010907)3.04276576
36Hydroxyprolinuria (HP:0003080)3.04276576
37Inability to walk (HP:0002540)3.03808283
38Abnormality of carpal bone ossification (HP:0006257)2.98818863
39Morphological abnormality of the inner ear (HP:0011390)2.96913672
40Pancreatic fibrosis (HP:0100732)2.93613810
41Pustule (HP:0200039)2.92395851
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92354663
43Abnormality of the nasal septum (HP:0000419)2.90892286
44Mediastinal lymphadenopathy (HP:0100721)2.87703097
45Axonal loss (HP:0003447)2.87330946
46Abnormal hair laboratory examination (HP:0003328)2.87250396
47Esophageal varix (HP:0002040)2.85376483
48Oligodontia (HP:0000677)2.72708947
49Agitation (HP:0000713)2.70889562
50Dysdiadochokinesis (HP:0002075)2.68563189
51Volvulus (HP:0002580)2.67202732
52Long palpebral fissure (HP:0000637)2.66241611
53Nail dystrophy (HP:0008404)2.65382169
54Entropion (HP:0000621)2.64438277
55Gingivitis (HP:0000230)2.62820240
56Hyperglycemia (HP:0003074)2.60979263
57Increased cerebral lipofuscin (HP:0011813)2.58250124
58Pancreatic islet-cell hyperplasia (HP:0004510)2.54894855
59Menorrhagia (HP:0000132)2.53622583
60Woolly hair (HP:0002224)2.52595291
61Cutaneous melanoma (HP:0012056)2.52459244
62Recurrent fungal infections (HP:0002841)2.50485842
63Broad nasal tip (HP:0000455)2.49489382
64Cheilitis (HP:0100825)2.47686837
65Myocardial infarction (HP:0001658)2.47496282
66Clumsiness (HP:0002312)2.47241888
67Parakeratosis (HP:0001036)2.45979150
68Alopecia of scalp (HP:0002293)2.44868415
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43930666
70Abnormal hand bone ossification (HP:0010660)2.43165014
71Hypoplasia of dental enamel (HP:0006297)2.40631550
72Large for gestational age (HP:0001520)2.39085729
73Periodontitis (HP:0000704)2.38248815
74Disinhibition (HP:0000734)2.37155122
75Hypotrichosis (HP:0001006)2.36164952
76Progressive inability to walk (HP:0002505)2.35549601
77Prostate neoplasm (HP:0100787)2.31361738
78Bilateral sensorineural hearing impairment (HP:0008619)2.31000226
79Pancreatic cysts (HP:0001737)2.30494141
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.30372106
81Aplasia cutis congenita (HP:0001057)2.28891950
82Recurrent skin infections (HP:0001581)2.26422038
83Abnormality of the carotid arteries (HP:0005344)2.26228529
84Optic nerve coloboma (HP:0000588)2.24782383
85Asplenia (HP:0001746)2.23973213
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.22087917
87Intellectual disability, moderate (HP:0002342)2.20827451
88Focal motor seizures (HP:0011153)2.20584677
89Osteolytic defects of the hand bones (HP:0009699)2.17384561
90Osteolytic defects of the phalanges of the hand (HP:0009771)2.17384561
91Abnormality of the distal phalanges of the toes (HP:0010182)2.17369613
92T lymphocytopenia (HP:0005403)2.17324409
93Blepharitis (HP:0000498)2.16154874
94Subacute progressive viral hepatitis (HP:0006572)2.13628924
95Autoimmune thrombocytopenia (HP:0001973)2.13132729
96Infertility (HP:0000789)2.12869936
97Oligodactyly (HP:0012165)2.12708994
98Hemorrhage of the eye (HP:0011885)2.12195728
99Abnormal ossification of hand bones (HP:0005921)2.12078162
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.11814118
101Palmoplantar hyperkeratosis (HP:0000972)2.10414095
102Cellulitis (HP:0100658)2.09302569
103Abnormal pupillary function (HP:0007686)2.09120078
104Segmental peripheral demyelination/remyelination (HP:0003481)2.08856215
105Abnormality of nail color (HP:0100643)2.08234898
106Premature loss of primary teeth (HP:0006323)2.07642463
107Fused cervical vertebrae (HP:0002949)2.07141585
108Orchitis (HP:0100796)2.06744808
109Tubular atrophy (HP:0000092)2.06682150
110Epiphyseal dysplasia (HP:0002656)2.06053742
111Increased IgE level (HP:0003212)2.05692247
112Skin ulcer (HP:0200042)2.05248332
113Aplasia/Hypoplasia of the spleen (HP:0010451)2.04819902
114Symphalangism affecting the phalanges of the hand (HP:0009773)2.03581783
115Nephritis (HP:0000123)2.03536124
116Abnormal blistering of the skin (HP:0008066)2.03429060
117Type II lissencephaly (HP:0007260)2.01464000
118Petechiae (HP:0000967)2.00587169
119Anhidrosis (HP:0000970)2.00061061
120Stomach cancer (HP:0012126)2.00011950
121Vascular calcification (HP:0004934)1.99053941
122Abnormality of the gastric mucosa (HP:0004295)1.97747250
123Palmar hyperkeratosis (HP:0010765)1.95777376
124Elevated erythrocyte sedimentation rate (HP:0003565)1.94893349
125Bilateral microphthalmos (HP:0007633)1.93979860
126Myositis (HP:0100614)1.93178638
127True hermaphroditism (HP:0010459)1.92958039
128Horizontal nystagmus (HP:0000666)1.92885599
129Central scotoma (HP:0000603)1.91876975
130Ketoacidosis (HP:0001993)1.90550115
131Amelogenesis imperfecta (HP:0000705)1.90504005
132Bone pain (HP:0002653)1.90330399
133Stomatitis (HP:0010280)1.89498681
134Abnormality of T cell number (HP:0011839)1.89361202
135Late onset (HP:0003584)1.89157225
136Fair hair (HP:0002286)1.88683466
137Abdominal distention (HP:0003270)1.86931095
138Conical tooth (HP:0000698)1.86680682
139Keratitis (HP:0000491)1.86550319
140Gingival bleeding (HP:0000225)1.86526577
141Impaired smooth pursuit (HP:0007772)1.86041199
142Biliary tract neoplasm (HP:0100574)1.85949291
143Urticaria (HP:0001025)1.85869922
144Broad-based gait (HP:0002136)1.84450393
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84245339
146Cervical subluxation (HP:0003308)1.82535886
147Toxemia of pregnancy (HP:0100603)1.81504410
148Hyperventilation (HP:0002883)1.80553215
149Cystic liver disease (HP:0006706)1.80163100
150Oligomenorrhea (HP:0000876)1.79966534
151Abnormality of endocrine pancreas physiology (HP:0012093)1.79787273
152Abnormality of the pancreatic islet cells (HP:0006476)1.79787273
153Concave nail (HP:0001598)1.79526310
154Insulin-resistant diabetes mellitus (HP:0000831)1.79145710
155Optic nerve hypoplasia (HP:0000609)1.79133220
156Ventricular tachycardia (HP:0004756)1.78939456
157Osteomyelitis (HP:0002754)1.78834977
158Focal segmental glomerulosclerosis (HP:0000097)1.78384405
159Oligodactyly (hands) (HP:0001180)1.78020498
160Bronchomalacia (HP:0002780)1.77582610
161Cardiovascular calcification (HP:0011915)1.77384953
162Abnormality of the ileum (HP:0001549)1.77143423
163Obstructive lung disease (HP:0006536)1.76988401
164Chronic obstructive pulmonary disease (HP:0006510)1.76988401
165Neoplasm of the lung (HP:0100526)1.76927007
166Elevated alkaline phosphatase (HP:0003155)1.75555604
167Hematochezia (HP:0002573)1.75268378
168Chronic otitis media (HP:0000389)1.75241084
169Areflexia of lower limbs (HP:0002522)1.75177039
170Flat acetabular roof (HP:0003180)1.74310684
171Hypoplasia of the brainstem (HP:0002365)1.73892331
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73892331
173Abnormality of the proximal phalanges of the hand (HP:0009834)1.73550763
174Submucous cleft hard palate (HP:0000176)1.73348811
175Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72517252
176Downturned corners of mouth (HP:0002714)1.72476007
177Ectropion (HP:0000656)1.72455062
178Vasculitis (HP:0002633)1.70535922
179Generalized hypopigmentation of hair (HP:0011358)1.70171797
180Abnormality of eosinophils (HP:0001879)1.70010275
181Gastrointestinal atresia (HP:0002589)1.69849561
182Broad alveolar ridges (HP:0000187)1.69228517
183Pruritus (HP:0000989)1.69077068
184Tongue fasciculations (HP:0001308)1.68466005
185Stenosis of the external auditory canal (HP:0000402)1.68331650
186Eosinophilia (HP:0001880)1.68201066
187Facial diplegia (HP:0001349)1.67485455
188Hypoalphalipoproteinemia (HP:0003233)1.67426139
189Glomerulosclerosis (HP:0000096)1.66867648
190Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66374979
191Sparse eyelashes (HP:0000653)1.65920176
192Nephronophthisis (HP:0000090)1.65582957
193Intention tremor (HP:0002080)1.65216161
194Abnormality of chromosome stability (HP:0003220)1.64827325
195Thin upper lip vermilion (HP:0000219)1.62787819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA29.69591836
2ADRBK26.68620959
3CDK85.69066100
4MST44.49789041
5PLK23.37984313
6MST1R2.83295022
7DYRK32.76084703
8GRK12.58923745
9EPHB12.33779178
10MAP3K32.12968559
11SIK12.01619361
12MAP3K142.01027781
13NEK91.97736384
14PINK11.88252063
15RIPK41.85289426
16STK101.79609198
17NME21.76564495
18LATS11.74929110
19TBK11.74612671
20EPHA31.73998777
21TRIB31.64279548
22ERN11.60712455
23MAP3K71.58331037
24BMX1.55536869
25PBK1.55502924
26RIPK11.53554490
27FER1.51228946
28PLK41.50494802
29LRRK21.48931382
30RPS6KB21.48656263
31TRPM71.42901577
32PIM21.41781390
33GRK61.41009861
34DAPK21.40297278
35WNK31.38675976
36CDK121.38552543
37MET1.34074610
38TNIK1.32657438
39CDK91.28911775
40PTK61.25767909
41PTK21.24740366
42NTRK31.20833220
43DMPK1.14906088
44MAP3K41.12722874
45FRK1.11976361
46ERBB31.10640356
47MAP3K21.10305773
48JAK31.09698538
49ZAK1.09578436
50IRAK11.05714716
51EPHB21.04980932
52PIK3CA1.04749933
53PRKD21.04541924
54TESK11.02567635
55TXK1.00048598
56RPS6KA40.98336852
57MAP4K20.97804348
58ADRBK10.96884137
59MAP4K10.94138932
60IRAK30.93042746
61PRKCG0.92567596
62TNK20.92413918
63IKBKB0.91582072
64MAP3K10.90707515
65BLK0.89469272
66PKN20.88162752
67MATK0.86152668
68MAP3K110.83201379
69JAK20.83026248
70ABL20.83015017
71DYRK1A0.81920783
72MAP2K20.79611705
73CSK0.79192574
74TGFBR20.78593053
75PTK2B0.77014334
76IKBKE0.76985606
77CHUK0.75447462
78MAP2K70.73594286
79STK30.73195754
80INSRR0.73130032
81LIMK10.72560732
82TYK20.71007853
83ACVR1B0.70149274
84PRKCI0.68712875
85MAPKAPK30.68435617
86JAK10.68278663
87NEK20.66958243
88FGFR40.66768552
89MAPK130.64364031
90MARK30.62969821
91FGFR30.62710215
92NTRK10.62651269
93CDK60.62644633
94TAOK30.60689862
95PAK30.59448828
96TAOK10.56703734
97BCR0.55923672
98NUAK10.53105328
99SGK10.52304903
100FGR0.51412481
101ITK0.51141763
102PDGFRB0.50520537
103PAK40.49467159
104MAPKAPK20.49427351
105PRKD30.48781789
106BMPR1B0.47939582
107NLK0.46981309
108PRKG20.46008180
109OXSR10.45950053
110PDK20.45374328
111EGFR0.45206643
112ABL10.45083369
113PRKG10.44873212
114LCK0.44844446
115IRAK40.44505179
116CAMK1D0.44025069
117ALK0.43933762
118ZAP700.43894615
119MAPK110.42880630
120NME10.42867322
121CDK50.42807696
122MUSK0.41679691
123STK390.41113969
124MAP2K10.39714810
125PIM10.39294230
126HCK0.37787605
127PRKD10.37448733
128CAMK2A0.36669873
129ICK0.36063466
130DDR20.35389668
131AKT30.35307964
132MAP2K30.35298574
133MAP2K40.33631972
134GSK3A0.32481136
135CLK10.32364476
136MARK10.31899573
137MAPK150.31708826
138BTK0.31293640
139PRKCH0.31198157
140ERBB20.31097569
141ERBB40.30908232
142PIK3CG0.30718100
143MAP3K80.29839976
144PRKCE0.28943492
145TAOK20.28896508
146EIF2AK20.26914986
147ATR0.26781252
148PRKCQ0.26766365
149ATM0.26747719
150MAP3K50.26412097
151INSR0.26351488
152SRC0.26237718
153PRKCB0.26228278
154PRKCD0.25928000
155SGK30.24762777
156CASK0.24658049
157MAP2K60.23309803
158STK38L0.22982323
159PRKAA10.22704104
160PNCK0.22279718
161PDPK10.22098560
162FGFR10.21061106
163RPS6KA10.21022852
164CAMK10.20458744
165MAPK120.20013954
166TGFBR10.19152995
167OBSCN0.18923666
168NTRK20.18360147
169PRKACA0.18198901
170MKNK20.17619198
171PHKG20.16792028

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005635.03920922
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.41827205
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.75058636
4Leishmaniasis_Homo sapiens_hsa051402.67418181
5Legionellosis_Homo sapiens_hsa051342.58171622
6Malaria_Homo sapiens_hsa051442.53992041
7Basal transcription factors_Homo sapiens_hsa030222.47232597
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.35412065
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20254547
10Rheumatoid arthritis_Homo sapiens_hsa053232.14962875
11Salmonella infection_Homo sapiens_hsa051322.04934413
12Fanconi anemia pathway_Homo sapiens_hsa034602.04885039
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04426568
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04255398
15Non-homologous end-joining_Homo sapiens_hsa034502.02362976
16Sulfur metabolism_Homo sapiens_hsa009201.97099663
17Graft-versus-host disease_Homo sapiens_hsa053321.95057191
18Hematopoietic cell lineage_Homo sapiens_hsa046401.93256198
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.89494741
20Phagosome_Homo sapiens_hsa041451.89189381
21TNF signaling pathway_Homo sapiens_hsa046681.88436985
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88130889
23Osteoclast differentiation_Homo sapiens_hsa043801.86667361
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.79515108
25Pertussis_Homo sapiens_hsa051331.79452018
26Tuberculosis_Homo sapiens_hsa051521.77153062
27Toxoplasmosis_Homo sapiens_hsa051451.76522743
28T cell receptor signaling pathway_Homo sapiens_hsa046601.70682004
29Adherens junction_Homo sapiens_hsa045201.68283123
30African trypanosomiasis_Homo sapiens_hsa051431.64928346
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64314771
32ABC transporters_Homo sapiens_hsa020101.62132801
33Phototransduction_Homo sapiens_hsa047441.61498877
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.59325543
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58414199
36Lysosome_Homo sapiens_hsa041421.57883584
37Morphine addiction_Homo sapiens_hsa050321.55234653
38Sphingolipid metabolism_Homo sapiens_hsa006001.53616711
39Amoebiasis_Homo sapiens_hsa051461.53348847
40Staphylococcus aureus infection_Homo sapiens_hsa051501.51793421
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51211291
42ECM-receptor interaction_Homo sapiens_hsa045121.51142942
43Olfactory transduction_Homo sapiens_hsa047401.50090299
44Nicotine addiction_Homo sapiens_hsa050331.49827537
45Primary immunodeficiency_Homo sapiens_hsa053401.48777751
46Shigellosis_Homo sapiens_hsa051311.48082973
47Nucleotide excision repair_Homo sapiens_hsa034201.46731681
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42895198
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.42473223
50Caffeine metabolism_Homo sapiens_hsa002321.42430352
51Tryptophan metabolism_Homo sapiens_hsa003801.41229849
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40355136
53Influenza A_Homo sapiens_hsa051641.38825387
54Proteoglycans in cancer_Homo sapiens_hsa052051.38801450
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.37942365
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35858531
57Renin secretion_Homo sapiens_hsa049241.35392201
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33811379
59Taste transduction_Homo sapiens_hsa047421.30117286
60Hepatitis C_Homo sapiens_hsa051601.29829004
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26237371
62Protein export_Homo sapiens_hsa030601.24315156
63Circadian entrainment_Homo sapiens_hsa047131.22152377
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.22018854
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19997938
66Apoptosis_Homo sapiens_hsa042101.19420633
67Collecting duct acid secretion_Homo sapiens_hsa049661.18970586
68Mineral absorption_Homo sapiens_hsa049781.18634881
69Small cell lung cancer_Homo sapiens_hsa052221.16975504
70Maturity onset diabetes of the young_Homo sapiens_hsa049501.15688316
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15019823
72Antigen processing and presentation_Homo sapiens_hsa046121.14271678
73Tight junction_Homo sapiens_hsa045301.14026291
74Acute myeloid leukemia_Homo sapiens_hsa052211.13174524
75Vibrio cholerae infection_Homo sapiens_hsa051101.12696119
76Prolactin signaling pathway_Homo sapiens_hsa049171.09545781
77N-Glycan biosynthesis_Homo sapiens_hsa005101.07306049
78Measles_Homo sapiens_hsa051621.05600239
79Serotonergic synapse_Homo sapiens_hsa047261.05158609
80Nitrogen metabolism_Homo sapiens_hsa009101.03220708
81Insulin secretion_Homo sapiens_hsa049111.02824384
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01394592
83Homologous recombination_Homo sapiens_hsa034401.00224280
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98624555
85Focal adhesion_Homo sapiens_hsa045100.98542814
86Selenocompound metabolism_Homo sapiens_hsa004500.97941171
87Type I diabetes mellitus_Homo sapiens_hsa049400.97707641
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97367707
89Viral myocarditis_Homo sapiens_hsa054160.95388537
90Circadian rhythm_Homo sapiens_hsa047100.93944203
91Pancreatic cancer_Homo sapiens_hsa052120.93840831
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93386997
93Butanoate metabolism_Homo sapiens_hsa006500.92920800
94Bladder cancer_Homo sapiens_hsa052190.92775338
95Histidine metabolism_Homo sapiens_hsa003400.90875373
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86397375
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86319152
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85537290
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85376963
100Fatty acid biosynthesis_Homo sapiens_hsa000610.84272778
101Other glycan degradation_Homo sapiens_hsa005110.83648853
102Allograft rejection_Homo sapiens_hsa053300.83154346
103Fatty acid degradation_Homo sapiens_hsa000710.83072565
104Retinol metabolism_Homo sapiens_hsa008300.82376688
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82001479
106Hippo signaling pathway_Homo sapiens_hsa043900.81926601
107GABAergic synapse_Homo sapiens_hsa047270.80480028
108Hepatitis B_Homo sapiens_hsa051610.79713905
109B cell receptor signaling pathway_Homo sapiens_hsa046620.79586463
110Chemokine signaling pathway_Homo sapiens_hsa040620.79263291
111Chronic myeloid leukemia_Homo sapiens_hsa052200.78519442
112Renal cell carcinoma_Homo sapiens_hsa052110.76389131
113Ovarian steroidogenesis_Homo sapiens_hsa049130.75740627
114RNA degradation_Homo sapiens_hsa030180.75339893
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75174049
116Platelet activation_Homo sapiens_hsa046110.72891630
117Dorso-ventral axis formation_Homo sapiens_hsa043200.71396963
118Phenylalanine metabolism_Homo sapiens_hsa003600.70450290
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70343209
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.65851025
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.65772935
122Chemical carcinogenesis_Homo sapiens_hsa052040.65649746
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64726502
124Folate biosynthesis_Homo sapiens_hsa007900.64561695
125Complement and coagulation cascades_Homo sapiens_hsa046100.63973832
126Insulin resistance_Homo sapiens_hsa049310.63972122
127Herpes simplex infection_Homo sapiens_hsa051680.62044758
128Type II diabetes mellitus_Homo sapiens_hsa049300.62007876
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61629296
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60420282
131HIF-1 signaling pathway_Homo sapiens_hsa040660.60174657
132Asthma_Homo sapiens_hsa053100.58874162
133VEGF signaling pathway_Homo sapiens_hsa043700.56610378
134Amphetamine addiction_Homo sapiens_hsa050310.56512751
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56472076
136Thyroid cancer_Homo sapiens_hsa052160.56025792
137Linoleic acid metabolism_Homo sapiens_hsa005910.55489522
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.55233233
139AMPK signaling pathway_Homo sapiens_hsa041520.55051708
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54542138
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54242245
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52834825
143MicroRNAs in cancer_Homo sapiens_hsa052060.52205528
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51407499
145TGF-beta signaling pathway_Homo sapiens_hsa043500.50456305
146MAPK signaling pathway_Homo sapiens_hsa040100.49074207
147Glutamatergic synapse_Homo sapiens_hsa047240.48664360
148Arachidonic acid metabolism_Homo sapiens_hsa005900.47729721
149Arginine biosynthesis_Homo sapiens_hsa002200.47556195
150Starch and sucrose metabolism_Homo sapiens_hsa005000.46421640
151Endometrial cancer_Homo sapiens_hsa052130.46342828
152Fat digestion and absorption_Homo sapiens_hsa049750.46239677
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46198370
154Cholinergic synapse_Homo sapiens_hsa047250.44950171
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44687845
156Prostate cancer_Homo sapiens_hsa052150.44392534
157Calcium signaling pathway_Homo sapiens_hsa040200.44092391
158PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42727645
159Endocytosis_Homo sapiens_hsa041440.41748075
160HTLV-I infection_Homo sapiens_hsa051660.41175170
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.40838453
162Renin-angiotensin system_Homo sapiens_hsa046140.40570527
163Ether lipid metabolism_Homo sapiens_hsa005650.40552928
164Galactose metabolism_Homo sapiens_hsa000520.39963195
165Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39035948
166Salivary secretion_Homo sapiens_hsa049700.38802098
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38373603
168cAMP signaling pathway_Homo sapiens_hsa040240.37403081
169Fatty acid metabolism_Homo sapiens_hsa012120.35389920
170Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35342965
171Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34045331
172Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33325563
173Glycerolipid metabolism_Homo sapiens_hsa005610.32886292
174Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29948948
175Vascular smooth muscle contraction_Homo sapiens_hsa042700.25736632
176Glucagon signaling pathway_Homo sapiens_hsa049220.21413111
177Axon guidance_Homo sapiens_hsa043600.19917534
178Oxytocin signaling pathway_Homo sapiens_hsa049210.17755214
179Metabolic pathways_Homo sapiens_hsa011000.16864343

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