PLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.81366114
2epoxygenase P450 pathway (GO:0019373)8.52540376
3omega-hydroxylase P450 pathway (GO:0097267)8.52360650
4L-phenylalanine catabolic process (GO:0006559)7.56380455
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56380455
6L-phenylalanine metabolic process (GO:0006558)7.23463230
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23463230
8aromatic amino acid family catabolic process (GO:0009074)6.80915616
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.47270914
10drug metabolic process (GO:0017144)6.21377972
11tryptophan catabolic process (GO:0006569)6.15458835
12indole-containing compound catabolic process (GO:0042436)6.15458835
13indolalkylamine catabolic process (GO:0046218)6.15458835
14oxidative demethylation (GO:0070989)6.08338685
15kynurenine metabolic process (GO:0070189)6.04468506
16bile acid biosynthetic process (GO:0006699)5.96001032
17glyoxylate metabolic process (GO:0046487)5.79167438
18tryptophan metabolic process (GO:0006568)5.78948555
19high-density lipoprotein particle remodeling (GO:0034375)5.72682928
20urea cycle (GO:0000050)5.69336936
21urea metabolic process (GO:0019627)5.69336936
22alpha-linolenic acid metabolic process (GO:0036109)5.63727017
23peptidyl-glutamic acid carboxylation (GO:0017187)5.47227848
24protein carboxylation (GO:0018214)5.47227848
25regulation of protein activation cascade (GO:2000257)5.42162191
26complement activation, alternative pathway (GO:0006957)5.39958284
27regulation of plasminogen activation (GO:0010755)5.34219076
28cysteine metabolic process (GO:0006534)5.33709862
29sulfur amino acid catabolic process (GO:0000098)5.33366682
30* negative regulation of fibrinolysis (GO:0051918)5.28953822
31nitrogen cycle metabolic process (GO:0071941)5.23090842
32ethanol metabolic process (GO:0006067)5.20718601
33* regulation of fibrinolysis (GO:0051917)5.20688978
34phenylpropanoid metabolic process (GO:0009698)5.18455928
35serine family amino acid catabolic process (GO:0009071)5.13596347
36bile acid metabolic process (GO:0008206)5.10889621
37regulation of complement activation (GO:0030449)5.04503804
38regulation of cholesterol esterification (GO:0010872)5.04406361
39reverse cholesterol transport (GO:0043691)5.00466253
40aromatic amino acid family metabolic process (GO:0009072)4.94605613
41plasma lipoprotein particle remodeling (GO:0034369)4.91093419
42protein-lipid complex remodeling (GO:0034368)4.91093419
43macromolecular complex remodeling (GO:0034367)4.91093419
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88379227
45regulation of triglyceride catabolic process (GO:0010896)4.86996714
46S-adenosylmethionine metabolic process (GO:0046500)4.80636547
47tyrosine metabolic process (GO:0006570)4.80156140
48homocysteine metabolic process (GO:0050667)4.73166426
49phospholipid efflux (GO:0033700)4.71559503
50regulation of humoral immune response (GO:0002920)4.69788759
51acylglycerol homeostasis (GO:0055090)4.66399528
52triglyceride homeostasis (GO:0070328)4.66399528
53negative regulation of sterol transport (GO:0032372)4.65841156
54negative regulation of cholesterol transport (GO:0032375)4.65841156
55alpha-amino acid catabolic process (GO:1901606)4.63656873
56* negative regulation of blood coagulation (GO:0030195)4.61319612
57* negative regulation of hemostasis (GO:1900047)4.61319612
58amino-acid betaine metabolic process (GO:0006577)4.60622644
59lysine metabolic process (GO:0006553)4.55675653
60lysine catabolic process (GO:0006554)4.55675653
61negative regulation of protein activation cascade (GO:2000258)4.54385813
62plasma lipoprotein particle clearance (GO:0034381)4.51570141
63cellular ketone body metabolic process (GO:0046950)4.48719808
64positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.46991364
65glycine metabolic process (GO:0006544)4.43469160
66bile acid and bile salt transport (GO:0015721)4.41464735
67alkaloid metabolic process (GO:0009820)4.39846163
68imidazole-containing compound metabolic process (GO:0052803)4.37026667
69indolalkylamine metabolic process (GO:0006586)4.35694331
70cholesterol efflux (GO:0033344)4.34782654
71coenzyme catabolic process (GO:0009109)4.33310405
72amine catabolic process (GO:0009310)4.26856998
73cellular biogenic amine catabolic process (GO:0042402)4.26856998
74cellular amino acid catabolic process (GO:0009063)4.26038310
75glutamate metabolic process (GO:0006536)4.24322637
76cellular glucuronidation (GO:0052695)4.22816906
77* negative regulation of coagulation (GO:0050819)4.18112119
78serine family amino acid metabolic process (GO:0009069)4.17457978
79* negative regulation of wound healing (GO:0061045)4.14641698
80benzene-containing compound metabolic process (GO:0042537)4.14364034
81plasma lipoprotein particle assembly (GO:0034377)4.13686776
82low-density lipoprotein particle remodeling (GO:0034374)4.13201181
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.13132641
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.13132641
85ethanol oxidation (GO:0006069)4.07539278
86dicarboxylic acid biosynthetic process (GO:0043650)4.04773398
87cellular modified amino acid catabolic process (GO:0042219)4.03533878
88serine family amino acid biosynthetic process (GO:0009070)4.02870445
89arginine metabolic process (GO:0006525)4.02775766
90aldehyde catabolic process (GO:0046185)3.99469666
91flavonoid metabolic process (GO:0009812)3.98541697
92blood coagulation, intrinsic pathway (GO:0007597)3.95692258
93intestinal cholesterol absorption (GO:0030299)3.94621690
94drug catabolic process (GO:0042737)3.90256325
95ketone body metabolic process (GO:1902224)3.88461489
96hormone catabolic process (GO:0042447)3.85344509
97positive regulation of triglyceride lipase activity (GO:0061365)3.85317701
98positive regulation of lipoprotein lipase activity (GO:0051006)3.85317701
99very-low-density lipoprotein particle assembly (GO:0034379)3.85156299
100negative regulation of lipase activity (GO:0060192)3.80948055
101positive regulation of lipid catabolic process (GO:0050996)3.80589977
102complement activation, classical pathway (GO:0006958)3.80551480
103cofactor catabolic process (GO:0051187)3.80214979
104phospholipid homeostasis (GO:0055091)3.79664987
105cholesterol homeostasis (GO:0042632)3.78316835
106protein activation cascade (GO:0072376)3.78272665
107complement activation (GO:0006956)3.77131524
108uronic acid metabolic process (GO:0006063)3.74750192
109glucuronate metabolic process (GO:0019585)3.74750192
110* fibrinolysis (GO:0042730)3.74280442
111doxorubicin metabolic process (GO:0044598)3.74249620
112daunorubicin metabolic process (GO:0044597)3.74249620
113polyketide metabolic process (GO:0030638)3.74249620
114plasma lipoprotein particle organization (GO:0071827)3.73511348
115carboxylic acid catabolic process (GO:0046395)3.72577122
116organic acid catabolic process (GO:0016054)3.72577122
117sterol homeostasis (GO:0055092)3.71973203
118* positive regulation of blood coagulation (GO:0030194)3.71893073
119* positive regulation of hemostasis (GO:1900048)3.71893073
120response to mercury ion (GO:0046689)3.71885842
121regulation of bile acid biosynthetic process (GO:0070857)3.70983644
122protein-lipid complex assembly (GO:0065005)3.70624875
123heme transport (GO:0015886)3.70170496
124short-chain fatty acid metabolic process (GO:0046459)3.65900779
125cytolysis (GO:0019835)3.64875055
126regulation of cholesterol homeostasis (GO:2000188)3.64381951
127fat-soluble vitamin biosynthetic process (GO:0042362)3.63940885
128acetyl-CoA metabolic process (GO:0006084)3.62705412
129opsonization (GO:0008228)3.58833437
130negative regulation of complement activation (GO:0045916)3.58253425
131acute-phase response (GO:0006953)3.58162877
132xenobiotic metabolic process (GO:0006805)3.53266274
133sodium-independent organic anion transport (GO:0043252)3.52242390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42148968
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21922441
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04718724
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52661594
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19003729
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18518217
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87336400
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07897757
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06113738
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08030969
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9881196
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99385385
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95353406
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61106227
15CLOCK_20551151_ChIP-Seq_293T_Human1.54468505
16GATA1_22025678_ChIP-Seq_K562_Human1.46450438
17* HTT_18923047_ChIP-ChIP_STHdh_Human1.45808169
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40798824
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30903446
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20710968
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19581974
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17474842
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14222063
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03068809
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01170866
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96068650
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96014712
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94181156
29IRF1_19129219_ChIP-ChIP_H3396_Human0.94015416
30SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91120620
31CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90540154
32HNFA_21074721_ChIP-Seq_CACO-2_Human0.89312919
33TRIM28_21343339_ChIP-Seq_HEK293_Human0.88748433
34NFE2_27457419_Chip-Seq_LIVER_Mouse0.88363457
35IRF8_22096565_ChIP-ChIP_GC-B_Human0.87102357
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86607661
37PHF8_20622853_ChIP-Seq_HELA_Human0.84128520
38AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83986704
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82736678
40RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82380813
41GATA4_25053715_ChIP-Seq_YYC3_Human0.79969460
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79270848
43PIAS1_25552417_ChIP-Seq_VCAP_Human0.78712580
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77892386
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77821133
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77126529
47EZH2_27294783_Chip-Seq_NPCs_Mouse0.76996642
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76743818
49NFYA_21822215_ChIP-Seq_K562_Human0.75500321
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74697991
51POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74673974
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.74442402
53ZNF263_19887448_ChIP-Seq_K562_Human0.74318330
54TP53_18474530_ChIP-ChIP_U2OS_Human0.72890738
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72886456
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71865823
57ER_23166858_ChIP-Seq_MCF-7_Human0.70899238
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70755072
59SOX2_21211035_ChIP-Seq_LN229_Human0.70135326
60GATA6_21074721_ChIP-Seq_CACO-2_Human0.68065472
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67844020
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67077955
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.65333272
64CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64754051
65ETV2_25802403_ChIP-Seq_MESCs_Mouse0.64586325
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64440355
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.64389884
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64181390
69NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64181390
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63759798
71RARB_24833708_ChIP-Seq_LIVER_Mouse0.63686678
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62958178
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62696922
74CRX_20693478_ChIP-Seq_RETINA_Mouse0.61448807
75RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61250625
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60384298
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59548142
78RAC3_21632823_ChIP-Seq_H3396_Human0.59446871
79ETV1_20927104_ChIP-Seq_GIST48_Human0.59306400
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58891605
81IGF1R_20145208_ChIP-Seq_DFB_Human0.58721410
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.57464580
83CEBPB_22108803_ChIP-Seq_LS180_Human0.57456328
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.56547667
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.56089834
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.55856075
87SMAD1_18555785_Chip-Seq_ESCs_Mouse0.54110189
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.54085856
89MYC_19829295_ChIP-Seq_ESCs_Human0.53613363
90LXR_22292898_ChIP-Seq_THP-1_Human0.53112204
91EGR1_19032775_ChIP-ChIP_M12_Human0.53076493
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.52939192
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.52924767
94SPI1_20517297_ChIP-Seq_HL60_Human0.52591868
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52335947
96ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51976305
97NFYB_21822215_ChIP-Seq_K562_Human0.51940798
98AR_20517297_ChIP-Seq_VCAP_Human0.51435888
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51319668
100MYC_19915707_ChIP-ChIP_AK7_Human0.51295335
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51225999
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51204153
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51174377
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.51028436
105PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.50695909
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50607335
107CBP_21632823_ChIP-Seq_H3396_Human0.48033470
108STAT1_17558387_ChIP-Seq_HELA_Human0.47117885
109P53_21459846_ChIP-Seq_SAOS-2_Human0.46374018
110* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45965439
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45580050
112GATA1_19941826_ChIP-Seq_K562_Human0.45565962
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.45132009
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44936605
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.44656955
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.43338537
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.42932394
118TAF2_19829295_ChIP-Seq_ESCs_Human0.41827663
119GATA2_19941826_ChIP-Seq_K562_Human0.41431074
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40735938
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.40677283
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40576674
123* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39804835
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.39560007
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39440093
126BCAT_22108803_ChIP-Seq_LS180_Human0.39191598
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39178588
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.38764812
129GATA6_25053715_ChIP-Seq_YYC3_Human0.38650875
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38265885
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.37432436
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35644819
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.35325379
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34770632
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.34315282
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.33960906
137NCOR_22424771_ChIP-Seq_293T_Human0.33799869
138CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33681892
139CDX2_22108803_ChIP-Seq_LS180_Human0.32931052
140ERG_20517297_ChIP-Seq_VCAP_Human0.32489463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.36051398
2MP0005360_urolithiasis7.56051632
3MP0005085_abnormal_gallbladder_physiolo6.46404692
4MP0005365_abnormal_bile_salt6.21094794
5MP0008875_abnormal_xenobiotic_pharmacok5.10835052
6MP0003806_abnormal_nucleotide_metabolis4.27537509
7MP0003252_abnormal_bile_duct3.90548926
8MP0010329_abnormal_lipoprotein_level3.63607392
9MP0009840_abnormal_foam_cell3.35738862
10MP0005083_abnormal_biliary_tract3.15049792
11MP0003195_calcinosis2.85666740
12MP0005332_abnormal_amino_acid2.75112651
13MP0001666_abnormal_nutrient_absorption2.60124463
14MP0003191_abnormal_cellular_cholesterol2.39072518
15* MP0000609_abnormal_liver_physiology2.15576368
16MP0004019_abnormal_vitamin_homeostasis2.12328265
17MP0002118_abnormal_lipid_homeostasis2.11710910
18MP0002138_abnormal_hepatobiliary_system1.96885314
19MP0003868_abnormal_feces_composition1.91422372
20MP0005319_abnormal_enzyme/_coenzyme1.83482445
21MP0001764_abnormal_homeostasis1.68122553
22MP0009697_abnormal_copulation1.65310022
23MP0005584_abnormal_enzyme/coenzyme_acti1.57703978
24MP0005451_abnormal_body_composition1.42943891
25MP0003011_delayed_dark_adaptation1.42460706
26MP0003656_abnormal_erythrocyte_physiolo1.32104630
27MP0003186_abnormal_redox_activity1.26105463
28MP0009643_abnormal_urine_homeostasis1.22897598
29* MP0000598_abnormal_liver_morphology1.16633696
30MP0003705_abnormal_hypodermis_morpholog1.16309141
31MP0005647_abnormal_sex_gland1.15388412
32MP0000604_amyloidosis1.13048267
33MP0002254_reproductive_system_inflammat1.05322961
34MP0010368_abnormal_lymphatic_system1.01043316
35* MP0009763_increased_sensitivity_to0.99398906
36MP0005636_abnormal_mineral_homeostasis0.94419323
37* MP0008469_abnormal_protein_level0.87668207
38* MP0009642_abnormal_blood_homeostasis0.87558108
39* MP0009764_decreased_sensitivity_to0.86114137
40MP0005408_hypopigmentation0.85428886
41MP0001915_intracranial_hemorrhage0.84774860
42MP0006036_abnormal_mitochondrial_physio0.82338068
43MP0005187_abnormal_penis_morphology0.82240450
44MP0005376_homeostasis/metabolism_phenot0.81138725
45MP0009765_abnormal_xenobiotic_induced0.79436006
46MP0005084_abnormal_gallbladder_morpholo0.78773001
47MP0002078_abnormal_glucose_homeostasis0.78705271
48MP0005670_abnormal_white_adipose0.76377473
49MP0002876_abnormal_thyroid_physiology0.76215871
50MP0005220_abnormal_exocrine_pancreas0.73532047
51MP0002971_abnormal_brown_adipose0.72890241
52MP0003879_abnormal_hair_cell0.70871625
53MP0001661_extended_life_span0.70025334
54MP0005334_abnormal_fat_pad0.69864916
55MP0004130_abnormal_muscle_cell0.69143047
56MP0005535_abnormal_body_temperature0.66886105
57MP0003329_amyloid_beta_deposits0.66011433
58MP0005266_abnormal_metabolism0.64620818
59MP0000639_abnormal_adrenal_gland0.63294541
60MP0001756_abnormal_urination0.58705552
61MP0005464_abnormal_platelet_physiology0.58155032
62MP0006035_abnormal_mitochondrial_morpho0.57401894
63MP0005448_abnormal_energy_balance0.57038468
64MP0009785_altered_susceptibility_to0.50800831
65MP0002822_catalepsy0.50629221
66MP0005395_other_phenotype0.50209438
67MP0003718_maternal_effect0.47066644
68MP0003638_abnormal_response/metabolism_0.46910624
69MP0002928_abnormal_bile_duct0.45802936
70MP0008873_increased_physiological_sensi0.45318420
71MP0002136_abnormal_kidney_physiology0.45148467
72MP0003436_decreased_susceptibility_to0.44485964
73MP0003724_increased_susceptibility_to0.43461361
74MP0004782_abnormal_surfactant_physiolog0.42659302
75MP0003075_altered_response_to0.42421437
76MP0003953_abnormal_hormone_level0.41473150
77MP0002837_dystrophic_cardiac_calcinosis0.41024757
78MP0005248_abnormal_Harderian_gland0.40609565
79MP0005166_decreased_susceptibility_to0.38989269
80MP0004381_abnormal_hair_follicle0.38147186
81MP0008872_abnormal_physiological_respon0.38040199
82MP0009672_abnormal_birth_weight0.37727351
83MP0005666_abnormal_adipose_tissue0.36378547
84* MP0008874_decreased_physiological_sensi0.35506712
85* MP0003690_abnormal_glial_cell0.35454742
86MP0000579_abnormal_nail_morphology0.35417474
87MP0004883_abnormal_blood_vessel0.35367988
88MP0005058_abnormal_lysosome_morphology0.34000001
89MP0000566_synostosis0.33980803
90MP0009115_abnormal_fat_cell0.33819481
91MP0001243_abnormal_dermal_layer0.33413714
92MP0006082_CNS_inflammation0.33359448
93MP0002796_impaired_skin_barrier0.32803305
94MP0001853_heart_inflammation0.32062430
95MP0002168_other_aberrant_phenotype0.31964859
96MP0002970_abnormal_white_adipose0.31261884
97MP0000230_abnormal_systemic_arterial0.31080819
98MP0009384_cardiac_valve_regurgitation0.30263366
99MP0005164_abnormal_response_to0.27878681
100* MP0000249_abnormal_blood_vessel0.27521753
101MP0002132_abnormal_respiratory_system0.27175975
102MP0003632_abnormal_nervous_system0.26682817
103* MP0001845_abnormal_inflammatory_respons0.26415509
104MP0003959_abnormal_lean_body0.24832568
105MP0002090_abnormal_vision0.24200382
106MP0002060_abnormal_skin_morphology0.23722161
107MP0001986_abnormal_taste_sensitivity0.23700002
108MP0005167_abnormal_blood-brain_barrier0.23060964
109MP0000427_abnormal_hair_cycle0.22680565
110MP0000920_abnormal_myelination0.21371824
111MP0001545_abnormal_hematopoietic_system0.19575673
112MP0005397_hematopoietic_system_phenotyp0.19575673
113MP0001944_abnormal_pancreas_morphology0.19483005
114MP0004142_abnormal_muscle_tone0.19161036
115MP0002332_abnormal_exercise_endurance0.18638285
116MP0002089_abnormal_postnatal_growth/wei0.17302601
117MP0005377_hearing/vestibular/ear_phenot0.17179262
118MP0003878_abnormal_ear_physiology0.17179262
119* MP0005023_abnormal_wound_healing0.16900525
120MP0004043_abnormal_pH_regulation0.16887582
121MP0004272_abnormal_basement_membrane0.15136799

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55357379
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37012806
3Intrahepatic cholestasis (HP:0001406)7.32653677
4Prolonged partial thromboplastin time (HP:0003645)6.70782355
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66753715
6Hypobetalipoproteinemia (HP:0003563)6.48207165
7Xanthomatosis (HP:0000991)6.29894771
8Hyperlipoproteinemia (HP:0010980)5.58096846
9Complement deficiency (HP:0004431)5.42700137
10Joint hemorrhage (HP:0005261)4.92600581
11Hypolipoproteinemia (HP:0010981)4.86904677
12Hyperammonemia (HP:0001987)4.59515091
13Abnormality of the common coagulation pathway (HP:0010990)4.58478437
14Epidermoid cyst (HP:0200040)4.48732141
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44577138
16Hyperglycinemia (HP:0002154)4.42454465
17Hypoalphalipoproteinemia (HP:0003233)4.25898618
18Abnormality of methionine metabolism (HP:0010901)4.25868946
19Ketosis (HP:0001946)4.23189113
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21984154
21Fat malabsorption (HP:0002630)4.14374484
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08761762
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07982370
24Abnormality of complement system (HP:0005339)3.96151336
25Abnormality of glycine metabolism (HP:0010895)3.88923529
26Abnormality of serine family amino acid metabolism (HP:0010894)3.88923529
27Hypoglycemic coma (HP:0001325)3.88701217
28Hyperglycinuria (HP:0003108)3.88347140
29Abnormality of pyrimidine metabolism (HP:0004353)3.83376052
30Abnormality of the intrinsic pathway (HP:0010989)3.82727940
31Conjugated hyperbilirubinemia (HP:0002908)3.74826821
32Hypercholesterolemia (HP:0003124)3.67045931
33Hyperbilirubinemia (HP:0002904)3.38337678
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32894358
35Abnormality of fatty-acid metabolism (HP:0004359)3.29626040
36Spontaneous abortion (HP:0005268)3.17093350
37* Nephritis (HP:0000123)3.15706229
38Steatorrhea (HP:0002570)3.10947215
39Delayed CNS myelination (HP:0002188)3.09103453
40Hypochromic microcytic anemia (HP:0004840)3.06202435
41Abnormality of serum amino acid levels (HP:0003112)3.04778179
42Abnormality of nucleobase metabolism (HP:0010932)3.03445355
43Hepatocellular carcinoma (HP:0001402)2.99212627
44Ketoacidosis (HP:0001993)2.98922445
45Myocardial infarction (HP:0001658)2.95791580
46Osteomalacia (HP:0002749)2.84752277
47Skin nodule (HP:0200036)2.76907090
48Metabolic acidosis (HP:0001942)2.74165676
49Systemic lupus erythematosus (HP:0002725)2.73891229
50Acanthocytosis (HP:0001927)2.66620183
51Abnormality of purine metabolism (HP:0004352)2.63480007
52Vascular calcification (HP:0004934)2.59526540
53Lethargy (HP:0001254)2.58118649
54Purpura (HP:0000979)2.55831559
55Glomerulonephritis (HP:0000099)2.54713962
56Dicarboxylic aciduria (HP:0003215)2.54370235
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54370235
58Hypoglycemic seizures (HP:0002173)2.52290832
59Fair hair (HP:0002286)2.50878742
60Abnormal gallbladder morphology (HP:0012437)2.50378090
61Cholelithiasis (HP:0001081)2.44434175
62Pulmonary embolism (HP:0002204)2.44134816
63Spastic diplegia (HP:0001264)2.44129767
64Mitral stenosis (HP:0001718)2.43570561
65Cerebral edema (HP:0002181)2.40335556
66Amyloidosis (HP:0011034)2.38141678
67Abnormal gallbladder physiology (HP:0012438)2.37946900
68Cholecystitis (HP:0001082)2.37946900
69Recurrent gram-negative bacterial infections (HP:0005420)2.36994922
70Gout (HP:0001997)2.36268237
71Irritability (HP:0000737)2.33895120
72Neonatal onset (HP:0003623)2.33245663
73Gingival bleeding (HP:0000225)2.31835063
74Cardiovascular calcification (HP:0011915)2.30116088
75Neonatal hypoglycemia (HP:0001998)2.27393640
76Malnutrition (HP:0004395)2.24474836
77Esophageal varix (HP:0002040)2.22395761
78Menorrhagia (HP:0000132)2.21439704
79Hyperphosphaturia (HP:0003109)2.20146784
80Reduced antithrombin III activity (HP:0001976)2.19459148
81Thrombophlebitis (HP:0004418)2.15058121
82Late onset (HP:0003584)2.13598072
83Pancreatitis (HP:0001733)2.12969888
84Poikilocytosis (HP:0004447)2.12384503
85Sensorimotor neuropathy (HP:0007141)2.11701907
86Brushfield spots (HP:0001088)2.10701350
87Enlarged kidneys (HP:0000105)2.08687703
88Vomiting (HP:0002013)2.04878894
89Hyperinsulinemic hypoglycemia (HP:0000825)2.04737109
90Glycosuria (HP:0003076)2.03913005
91Abnormality of urine glucose concentration (HP:0011016)2.03913005
92Hemorrhage of the eye (HP:0011885)2.02770061
93Abnormality of the gallbladder (HP:0005264)2.02452666
94Opisthotonus (HP:0002179)2.01874076
95Joint swelling (HP:0001386)2.01001827
96Generalized aminoaciduria (HP:0002909)1.99346250
97Elevated alkaline phosphatase (HP:0003155)1.97856347
98Abnormality of iron homeostasis (HP:0011031)1.96206192
99Arthropathy (HP:0003040)1.93105208
100Rickets (HP:0002748)1.93076400
101Abnormality of transition element cation homeostasis (HP:0011030)1.92494454
102Increased serum ferritin (HP:0003281)1.89936064
103Abnormality of the Achilles tendon (HP:0005109)1.87057518
104Hypophosphatemic rickets (HP:0004912)1.85684395
105Abnormal cartilage morphology (HP:0002763)1.85290725
106Renal cortical cysts (HP:0000803)1.83252279
107Bifid scrotum (HP:0000048)1.82945844
108Epistaxis (HP:0000421)1.82844279
109Hydroxyprolinuria (HP:0003080)1.80373929
110Abnormality of proline metabolism (HP:0010907)1.80373929
111Elevated hepatic transaminases (HP:0002910)1.80277851
112Gangrene (HP:0100758)1.79856896
113Abnormal enzyme/coenzyme activity (HP:0012379)1.79529894
114Abnormality of alkaline phosphatase activity (HP:0004379)1.79199343
115Status epilepticus (HP:0002133)1.77887738
116Alkalosis (HP:0001948)1.77705154
117Increased mean platelet volume (HP:0011877)1.75881895
118Reticulocytosis (HP:0001923)1.75069490
119Abnormal urine phosphate concentration (HP:0012599)1.75001100
120Hyperglycemia (HP:0003074)1.74079395
121Generalized hypopigmentation of hair (HP:0011358)1.72404680
122Abnormality of vitamin metabolism (HP:0100508)1.71642113
123Cerebral palsy (HP:0100021)1.64983535
124Abnormal biliary tract physiology (HP:0012439)1.62080034
125Bile duct proliferation (HP:0001408)1.62080034
126Abnormal platelet volume (HP:0011876)1.58158621
127Impaired platelet aggregation (HP:0003540)1.57287994
128Abnormal platelet function (HP:0011869)1.57287994
129Abnormal delivery (HP:0001787)1.56778781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15509662
2FGFR44.69024813
3SIK14.63502889
4ERN14.39707537
5TAOK33.20680754
6INSRR2.98842442
7ERBB42.87310828
8MAP2K42.34487648
9PKN22.23997301
10WNK32.20826137
11MST1R2.11075258
12NTRK31.98266862
13FLT31.92793593
14PIK3CG1.91564716
15MAPK111.89910724
16TRIB31.79539420
17TYK21.73648738
18DAPK21.67435373
19LATS11.61462282
20PTK61.48370334
21ABL21.47268572
22PRPF4B1.43844865
23CAMKK21.40399667
24NEK91.39622371
25NLK1.36239626
26FGFR21.36131230
27KDR1.34920799
28FRK1.32331495
29PDK21.24344694
30JAK21.24249056
31FER1.23836250
32MAP3K21.23010864
33MAP3K71.17641512
34TNK21.14740868
35PRKAA21.11410776
36PINK11.08944240
37GRK61.07650875
38MAP2K31.06840979
39TBK11.04477974
40JAK11.03712714
41ERBB21.03424880
42MAP3K101.01073563
43MAPK40.98160584
44PRKG10.95413391
45MAP3K140.93866863
46PRKCZ0.91360962
47PRKACA0.90893590
48EPHB10.89011907
49BRSK20.86910044
50MET0.86045523
51MAP3K30.82265945
52MAPK120.82112421
53CDK60.81502199
54EPHA30.81185041
55MAP3K110.81120795
56STK38L0.80400644
57TIE10.78479424
58MAPK150.78369616
59PRKACG0.77312718
60AKT30.77233664
61MYLK0.76405222
62DYRK1B0.72696591
63CAMK1D0.72535947
64CAMK2G0.70329054
65CSK0.70135223
66ACVR1B0.68655735
67CSNK1D0.68428638
68MAP3K120.66989039
69GSK3A0.66410484
70MAP2K60.64990344
71PRKAA10.64857595
72PRKCB0.63114312
73RIPK10.61687336
74SGK30.61582792
75CSNK1E0.60304434
76TGFBR20.58456719
77RPS6KA30.57472585
78CSF1R0.57470700
79FGFR30.57429534
80MAPK70.57089710
81IRAK30.56916328
82OXSR10.55678912
83PTK20.55566828
84IKBKE0.53896867
85ZAP700.53614020
86PRKCQ0.50576789
87PDPK10.50398111
88SGK10.49989239
89EPHA40.49973190
90CSNK1G10.47585066
91TAOK20.46730419
92BLK0.46563260
93SGK20.44542888
94GRK10.43972754
95IGF1R0.43788199
96CSNK2A10.43526474
97MAP3K50.43443815
98CAMKK10.43409181
99RET0.42709500
100MAP2K10.42638152
101CDK40.42554032
102SRC0.42414826
103BCR0.42197863
104PRKCG0.41388243
105MAP3K130.40956806
106KSR20.40416202
107ICK0.39868570
108PKN10.38699171
109CSNK2A20.38630444
110MAPKAPK30.36603090
111MTOR0.36351705
112MAP3K60.35958618
113CSNK1A10.34733407
114PBK0.33938077
115EGFR0.33904224
116CAMK40.32901102
117PDK10.31421846
118SGK4940.31106746
119SGK2230.31106746
120MAP3K10.29560678
121CSNK1G20.27391066
122PRKCA0.25714816
123PIK3CA0.25519281
124LATS20.25168689
125CAMK1G0.24709738
126CSNK1G30.24299271
127IRAK10.23672735
128PAK30.21354872
129ABL10.20496788
130IRAK20.20078790
131BMX0.19108496
132PRKACB0.18423744

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53591091
2Nitrogen metabolism_Homo sapiens_hsa009103.65505826
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38523659
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35732371
5Arginine biosynthesis_Homo sapiens_hsa002203.08005745
6* Complement and coagulation cascades_Homo sapiens_hsa046102.77252573
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71226204
8Tryptophan metabolism_Homo sapiens_hsa003802.68110468
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64473086
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55729124
11Fatty acid degradation_Homo sapiens_hsa000712.48361426
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37886989
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24232690
14Butanoate metabolism_Homo sapiens_hsa006502.15625237
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15412582
16Peroxisome_Homo sapiens_hsa041462.06573570
17Chemical carcinogenesis_Homo sapiens_hsa052041.96536198
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93947004
19Propanoate metabolism_Homo sapiens_hsa006401.92283890
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.92053657
21Histidine metabolism_Homo sapiens_hsa003401.91089433
22PPAR signaling pathway_Homo sapiens_hsa033201.86644871
23Fatty acid metabolism_Homo sapiens_hsa012121.81105186
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76999252
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74845284
26beta-Alanine metabolism_Homo sapiens_hsa004101.71119345
27Caffeine metabolism_Homo sapiens_hsa002321.70224840
28Retinol metabolism_Homo sapiens_hsa008301.69720393
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65408294
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62617871
31* Staphylococcus aureus infection_Homo sapiens_hsa051501.62415950
32Selenocompound metabolism_Homo sapiens_hsa004501.58054127
33Phenylalanine metabolism_Homo sapiens_hsa003601.55897341
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50366664
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50336998
36Bile secretion_Homo sapiens_hsa049761.49537524
37Tyrosine metabolism_Homo sapiens_hsa003501.44430403
38Pyruvate metabolism_Homo sapiens_hsa006201.35730429
39Sulfur metabolism_Homo sapiens_hsa009201.33932914
40Fatty acid elongation_Homo sapiens_hsa000621.33508313
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.31376760
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27593526
43Steroid biosynthesis_Homo sapiens_hsa001001.22046009
44ABC transporters_Homo sapiens_hsa020101.21936216
45Folate biosynthesis_Homo sapiens_hsa007901.20672348
46Biosynthesis of amino acids_Homo sapiens_hsa012301.20084967
47Fat digestion and absorption_Homo sapiens_hsa049751.19001462
48Carbon metabolism_Homo sapiens_hsa012001.12474031
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02126185
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01517016
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00719231
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.99212712
53Vitamin B6 metabolism_Homo sapiens_hsa007500.98654899
54Arginine and proline metabolism_Homo sapiens_hsa003300.96251058
55Sulfur relay system_Homo sapiens_hsa041220.94533175
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86870637
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86839101
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82749944
59Lysine degradation_Homo sapiens_hsa003100.81222541
60One carbon pool by folate_Homo sapiens_hsa006700.77363397
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70069296
62Glycerolipid metabolism_Homo sapiens_hsa005610.66936714
63Glutathione metabolism_Homo sapiens_hsa004800.65601340
64Pentose phosphate pathway_Homo sapiens_hsa000300.57084858
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53968829
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46160518
67Metabolic pathways_Homo sapiens_hsa011000.45540778
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43552610
69Prion diseases_Homo sapiens_hsa050200.36041575
70Pertussis_Homo sapiens_hsa051330.34819506
71Galactose metabolism_Homo sapiens_hsa000520.25906230
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25696855
73Insulin resistance_Homo sapiens_hsa049310.23045422
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22856483
75Linoleic acid metabolism_Homo sapiens_hsa005910.21985291
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21730600
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20268633
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15226847
79Glucagon signaling pathway_Homo sapiens_hsa049220.09831858
80AMPK signaling pathway_Homo sapiens_hsa041520.01731460
81Ether lipid metabolism_Homo sapiens_hsa00565-0.2416264
82Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2416206
83Bladder cancer_Homo sapiens_hsa05219-0.2410724
84Amoebiasis_Homo sapiens_hsa05146-0.2404462
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2345157
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2314000
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2261114
88N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2211004
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.2131705
90Sphingolipid metabolism_Homo sapiens_hsa00600-0.2076504
91Circadian rhythm_Homo sapiens_hsa04710-0.1971460
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1934319
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1908405
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1868136
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1827486
96Hepatitis C_Homo sapiens_hsa05160-0.1764065
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1697560
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1633223
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1549882
100Regulation of autophagy_Homo sapiens_hsa04140-0.1451445
101African trypanosomiasis_Homo sapiens_hsa05143-0.1307747
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1232046
103Insulin signaling pathway_Homo sapiens_hsa04910-0.0993413
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0835597
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0761651
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0715830
107Mineral absorption_Homo sapiens_hsa04978-0.0669678
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0464620
109Other glycan degradation_Homo sapiens_hsa00511-0.0351506
110Serotonergic synapse_Homo sapiens_hsa04726-0.0223595

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