ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	8.20671436
2	glyoxylate metabolic process (GO:0046487)	7.99335865
3	exogenous drug catabolic process (GO:0042738)	7.85980808
4	epoxygenase P450 pathway (GO:0019373)	7.01933045
5	omega-hydroxylase P450 pathway (GO:0097267)	6.89826748
6	serine family amino acid catabolic process (GO:0009071)	6.82267146
7	oxidative demethylation (GO:0070989)	6.21206430
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.98073603
9	L-phenylalanine catabolic process (GO:0006559)	5.98073603
10	complement activation, alternative pathway (GO:0006957)	5.86321848
11	regulation of fibrinolysis (GO:0051917)	5.84352545
12	glycine metabolic process (GO:0006544)	5.63827271
13	bile acid biosynthetic process (GO:0006699)	5.52574812
14	negative regulation of fibrinolysis (GO:0051918)	5.51812542
15	phenylpropanoid metabolic process (GO:0009698)	5.43125023
16	regulation of protein activation cascade (GO:2000257)	5.29814697
17	ethanol oxidation (GO:0006069)	5.12578030
18	aromatic amino acid family catabolic process (GO:0009074)	5.06907858
19	pyrimidine nucleobase catabolic process (GO:0006208)	4.99751883
20	drug metabolic process (GO:0017144)	4.93948109
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.87339327
22	L-phenylalanine metabolic process (GO:0006558)	4.87339327
23	regulation of complement activation (GO:0030449)	4.78197860
24	cellular glucuronidation (GO:0052695)	4.71428278
25	protein carboxylation (GO:0018214)	4.64822495
26	peptidyl-glutamic acid carboxylation (GO:0017187)	4.64822495
27	serine family amino acid metabolic process (GO:0009069)	4.64621755
28	urea metabolic process (GO:0019627)	4.56504519
29	glucuronate metabolic process (GO:0019585)	4.54282297
30	uronic acid metabolic process (GO:0006063)	4.54282297
31	S-adenosylmethionine metabolic process (GO:0046500)	4.53274172
32	bile acid metabolic process (GO:0008206)	4.52869999
33	fibrinolysis (GO:0042730)	4.36046870
34	bile acid and bile salt transport (GO:0015721)	4.34448671
35	alkaloid metabolic process (GO:0009820)	4.31446868
36	indole-containing compound catabolic process (GO:0042436)	4.25871640
37	indolalkylamine catabolic process (GO:0046218)	4.25871640
38	tryptophan catabolic process (GO:0006569)	4.25871640
39	heme transport (GO:0015886)	4.24212343
40	blood coagulation, intrinsic pathway (GO:0007597)	4.20334401
41	cellular ketone body metabolic process (GO:0046950)	4.15143408
42	nucleobase catabolic process (GO:0046113)	4.12664277
43	nitrogen cycle metabolic process (GO:0071941)	4.03388531
44	regulation of triglyceride catabolic process (GO:0010896)	3.92552970
45	negative regulation of sterol transport (GO:0032372)	3.91917016
46	negative regulation of cholesterol transport (GO:0032375)	3.91917016
47	arginine metabolic process (GO:0006525)	3.86670662
48	ethanol metabolic process (GO:0006067)	3.85951685
49	alpha-amino acid catabolic process (GO:1901606)	3.84036675
50	triglyceride homeostasis (GO:0070328)	3.74686474
51	acylglycerol homeostasis (GO:0055090)	3.74686474
52	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.72714183
53	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.71367652
54	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.71367652
55	aldehyde catabolic process (GO:0046185)	3.70262979
56	amino-acid betaine metabolic process (GO:0006577)	3.70163609
57	urea cycle (GO:0000050)	3.68880509
58	serine family amino acid biosynthetic process (GO:0009070)	3.64521495
59	ketone body metabolic process (GO:1902224)	3.62880369
60	imidazole-containing compound metabolic process (GO:0052803)	3.57266342
61	water-soluble vitamin biosynthetic process (GO:0042364)	3.55179606
62	tryptophan metabolic process (GO:0006568)	3.52580982
63	protein activation cascade (GO:0072376)	3.50176000
64	steroid catabolic process (GO:0006706)	3.46617467
65	regulation of humoral immune response (GO:0002920)	3.44781117
66	cellular biogenic amine catabolic process (GO:0042402)	3.36234621
67	amine catabolic process (GO:0009310)	3.36234621
68	hormone catabolic process (GO:0042447)	3.34276454
69	aromatic amino acid family metabolic process (GO:0009072)	3.31144984
70	complement activation (GO:0006956)	3.30638341
71	regulation of glucokinase activity (GO:0033131)	3.27370863
72	regulation of hexokinase activity (GO:1903299)	3.27370863
73	opsonization (GO:0008228)	3.25077802
74	cellular amino acid catabolic process (GO:0009063)	3.24224612
75	regulation of plasminogen activation (GO:0010755)	3.21085113
76	negative regulation of blood coagulation (GO:0030195)	3.12981371
77	negative regulation of hemostasis (GO:1900047)	3.12981371
78	kynurenine metabolic process (GO:0070189)	3.12444041
79	cytolysis (GO:0019835)	3.11496124
80	complement activation, classical pathway (GO:0006958)	3.08148263
81	sodium-independent organic anion transport (GO:0043252)	3.07457286
82	L-methionine salvage (GO:0071267)	3.05366701
83	L-methionine biosynthetic process (GO:0071265)	3.05366701
84	amino acid salvage (GO:0043102)	3.05366701
85	protein-lipid complex remodeling (GO:0034368)	3.04259055
86	macromolecular complex remodeling (GO:0034367)	3.04259055
87	plasma lipoprotein particle remodeling (GO:0034369)	3.04259055
88	tyrosine metabolic process (GO:0006570)	3.03995977
89	iron coordination entity transport (GO:1901678)	3.03795100
90	peptidyl-glutamic acid modification (GO:0018200)	3.02461341
91	indolalkylamine metabolic process (GO:0006586)	3.02239003
92	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.01998590
93	cysteine metabolic process (GO:0006534)	3.01210931
94	glutamate metabolic process (GO:0006536)	2.99655165
95	arginine catabolic process (GO:0006527)	2.99469691
96	dopamine transport (GO:0015872)	2.98476315
97	negative regulation of wound healing (GO:0061045)	2.94860943
98	negative regulation of protein activation cascade (GO:2000258)	2.93614646
99	coenzyme catabolic process (GO:0009109)	2.93461425
100	behavioral response to nicotine (GO:0035095)	2.91539885

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.86720609
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67299951
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.63378877
4	VDR_22108803_ChIP-Seq_LS180_Human	3.34554665
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.14828726
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.05485647
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80825677
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52727315
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42815372
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41632425
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36639978
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.32652116
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.25972589
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.20846749
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.12170206
16	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.09778903
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06976306
18	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.06828725
19	FUS_26573619_Chip-Seq_HEK293_Human	2.02817906
20	ER_23166858_ChIP-Seq_MCF-7_Human	2.01320821
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94211923
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.94118834
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92105435
24	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.91973552
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.86215033
26	P300_19829295_ChIP-Seq_ESCs_Human	1.82730841
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.80819452
28	EWS_26573619_Chip-Seq_HEK293_Human	1.77046788
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.74180401
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.64579630
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61454161
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.58784078
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58082936
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57763061
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.56119555
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.53578495
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.51787590
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.51766909
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.49343316
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49100913
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49100913
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45976195
43	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44918497
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43673449
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42523375
46	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.40775820
47	STAT3_23295773_ChIP-Seq_U87_Human	1.40603198
48	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.38271094
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36265131
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36047695
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35596011
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.35596011
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33449159
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32499198
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32377698
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.30793746
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29806426
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29641700
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24186810
60	TCF4_23295773_ChIP-Seq_U87_Human	1.22687230
61	NCOR_22424771_ChIP-Seq_293T_Human	1.22189770
62	AR_20517297_ChIP-Seq_VCAP_Human	1.19443844
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18061470
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16526822
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16009404
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15795655
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14666282
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.14464995
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13776804
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09630155
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08766287
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08573336
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08562346
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07972379
75	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07953840
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07858581
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07298967
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07229173
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07229173
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06164340
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06164340
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06124210
83	AR_25329375_ChIP-Seq_VCAP_Human	1.06051852
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05471316
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04320891
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04009988
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03963165
88	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.03229873
89	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.03174245
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02360572
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01093954
92	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00073760
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97120626
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95377353
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95069972
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.94010663
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93355158
98	CBP_21632823_ChIP-Seq_H3396_Human	0.93182987
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.92398427
100	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92012033

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.81790650
2	MP0005360_urolithiasis	4.64180599
3	MP0005085_abnormal_gallbladder_physiolo	4.35611224
4	MP0002876_abnormal_thyroid_physiology	4.14605269
5	MP0008875_abnormal_xenobiotic_pharmacok	4.05624979
6	MP0002138_abnormal_hepatobiliary_system	3.87808212
7	MP0005365_abnormal_bile_salt	3.69852070
8	MP0003195_calcinosis	3.67106634
9	MP0003252_abnormal_bile_duct	3.41485127
10	MP0003880_abnormal_central_pattern	3.11380553
11	MP0009697_abnormal_copulation	2.90357150
12	MP0006276_abnormal_autonomic_nervous	2.14769325
13	MP0003787_abnormal_imprinting	2.11710354
14	MP0003868_abnormal_feces_composition	2.08430169
15	MP0001666_abnormal_nutrient_absorption	1.86535538
16	MP0004133_heterotaxia	1.85093910
17	MP0002653_abnormal_ependyma_morphology	1.82188768
18	MP0006072_abnormal_retinal_apoptosis	1.80844309
19	MP0001984_abnormal_olfaction	1.75001786
20	MP0001764_abnormal_homeostasis	1.72357418
21	MP0000372_irregular_coat_pigmentation	1.71079030
22	MP0005332_abnormal_amino_acid	1.64415054
23	MP0003806_abnormal_nucleotide_metabolis	1.63624188
24	MP0005551_abnormal_eye_electrophysiolog	1.61352718
25	MP0008877_abnormal_DNA_methylation	1.61211068
26	MP0010329_abnormal_lipoprotein_level	1.51446840
27	MP0008995_early_reproductive_senescence	1.41756896
28	MP0004142_abnormal_muscle_tone	1.41671826
29	MP0008789_abnormal_olfactory_epithelium	1.41559344
30	MP0001986_abnormal_taste_sensitivity	1.40685313
31	MP0003123_paternal_imprinting	1.34863804
32	MP0006292_abnormal_olfactory_placode	1.32574939
33	MP0004019_abnormal_vitamin_homeostasis	1.21713107
34	MP0003121_genomic_imprinting	1.21459281
35	MP0009764_decreased_sensitivity_to	1.17309243
36	MP0004885_abnormal_endolymph	1.13855937
37	MP0008872_abnormal_physiological_respon	1.13613544
38	MP0000778_abnormal_nervous_system	1.06279554
39	MP0005423_abnormal_somatic_nervous	1.04484608
40	MP0002254_reproductive_system_inflammat	1.02746446
41	MP0003283_abnormal_digestive_organ	1.02223810
42	MP0002118_abnormal_lipid_homeostasis	1.01013742
43	MP0005394_taste/olfaction_phenotype	0.96430192
44	MP0005499_abnormal_olfactory_system	0.96430192
45	MP0002234_abnormal_pharynx_morphology	0.95675133
46	MP0003122_maternal_imprinting	0.94904420
47	MP0000609_abnormal_liver_physiology	0.94856878
48	MP0010386_abnormal_urinary_bladder	0.94239964
49	MP0002928_abnormal_bile_duct	0.91432142
50	MP0002638_abnormal_pupillary_reflex	0.90607094
51	MP0001293_anophthalmia	0.89675305
52	MP0002837_dystrophic_cardiac_calcinosis	0.89164061
53	MP0002282_abnormal_trachea_morphology	0.89161880
54	MP0005410_abnormal_fertilization	0.86309583
55	MP0005645_abnormal_hypothalamus_physiol	0.85978865
56	MP0005253_abnormal_eye_physiology	0.84393293
57	MP0002102_abnormal_ear_morphology	0.83773267
58	MP0005646_abnormal_pituitary_gland	0.81300754
59	MP0001485_abnormal_pinna_reflex	0.80937799
60	MP0009745_abnormal_behavioral_response	0.80922197
61	MP0004742_abnormal_vestibular_system	0.78723210
62	MP0003959_abnormal_lean_body	0.78687209
63	MP0008775_abnormal_heart_ventricle	0.78274424
64	MP0005408_hypopigmentation	0.78148195
65	MP0005395_other_phenotype	0.77680911
66	MP0002160_abnormal_reproductive_system	0.77347625
67	MP0001501_abnormal_sleep_pattern	0.76836052
68	MP0002272_abnormal_nervous_system	0.76236501
69	MP0003718_maternal_effect	0.74426564
70	MP0003656_abnormal_erythrocyte_physiolo	0.74067460
71	MP0005266_abnormal_metabolism	0.74025626
72	MP0005084_abnormal_gallbladder_morpholo	0.73857463
73	MP0005195_abnormal_posterior_eye	0.73772541
74	MP0010368_abnormal_lymphatic_system	0.73761839
75	MP0001486_abnormal_startle_reflex	0.72445355
76	MP0002132_abnormal_respiratory_system	0.70720825
77	MP0003890_abnormal_embryonic-extraembry	0.69816009
78	MP0001968_abnormal_touch/_nociception	0.68972508
79	MP0004859_abnormal_synaptic_plasticity	0.68316021
80	MP0001440_abnormal_grooming_behavior	0.67623046
81	MP0000631_abnormal_neuroendocrine_gland	0.67395740
82	MP0002067_abnormal_sensory_capabilities	0.66765972
83	MP0005389_reproductive_system_phenotype	0.65933676
84	MP0002822_catalepsy	0.65718227
85	MP0006036_abnormal_mitochondrial_physio	0.64906372
86	MP0009765_abnormal_xenobiotic_induced	0.64445711
87	MP0008961_abnormal_basal_metabolism	0.63494509
88	MP0009379_abnormal_foot_pigmentation	0.63027240
89	MP0003011_delayed_dark_adaptation	0.60852294
90	MP0002168_other_aberrant_phenotype	0.59962010
91	MP0005319_abnormal_enzyme/_coenzyme	0.58323397
92	MP0002938_white_spotting	0.57978578
93	MP0005386_behavior/neurological_phenoty	0.57424557
94	MP0004924_abnormal_behavior	0.57424557
95	MP0003638_abnormal_response/metabolism_	0.57284793
96	MP0005376_homeostasis/metabolism_phenot	0.56500832
97	MP0002971_abnormal_brown_adipose	0.55949425
98	MP0009642_abnormal_blood_homeostasis	0.55827975
99	MP0001919_abnormal_reproductive_system	0.55785869
100	MP0000639_abnormal_adrenal_gland	0.55308564

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	6.21399261
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.99115681
3	Deep venous thrombosis (HP:0002625)	5.87361061
4	Complement deficiency (HP:0004431)	5.29432317
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.19504034
6	Hyperlipoproteinemia (HP:0010980)	4.74286125
7	Hypobetalipoproteinemia (HP:0003563)	4.43176842
8	Hyperglycinemia (HP:0002154)	4.32379790
9	Joint hemorrhage (HP:0005261)	3.92900402
10	Conjugated hyperbilirubinemia (HP:0002908)	3.92759105
11	Fair hair (HP:0002286)	3.76614656
12	Abnormality of pyrimidine metabolism (HP:0004353)	3.75407475
13	Abnormality of complement system (HP:0005339)	3.72470557
14	Intrahepatic cholestasis (HP:0001406)	3.64863433
15	Chronic hepatic failure (HP:0100626)	3.62186872
16	Abnormality of methionine metabolism (HP:0010901)	3.34653772
17	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.10500915
18	Systemic lupus erythematosus (HP:0002725)	2.97872795
19	Abnormal biliary tract physiology (HP:0012439)	2.97134580
20	Bile duct proliferation (HP:0001408)	2.97134580
21	Abnormality of glycine metabolism (HP:0010895)	2.90086608
22	Abnormality of serine family amino acid metabolism (HP:0010894)	2.90086608
23	Generalized hypopigmentation of hair (HP:0011358)	2.82199496
24	Reduced antithrombin III activity (HP:0001976)	2.80304479
25	Abnormality of serum amino acid levels (HP:0003112)	2.79103900
26	Hyperglycinuria (HP:0003108)	2.66602060
27	Pancreatic fibrosis (HP:0100732)	2.62737795
28	Congenital stationary night blindness (HP:0007642)	2.59355497
29	Spontaneous abortion (HP:0005268)	2.59189829
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.58524315
31	Osteomalacia (HP:0002749)	2.56850221
32	Abnormality of midbrain morphology (HP:0002418)	2.53941989
33	Molar tooth sign on MRI (HP:0002419)	2.53941989
34	B lymphocytopenia (HP:0010976)	2.49080074
35	Thyroid-stimulating hormone excess (HP:0002925)	2.48502291
36	Methylmalonic acidemia (HP:0002912)	2.47669721
37	Thyroiditis (HP:0100646)	2.46944778
38	Septo-optic dysplasia (HP:0100842)	2.44628267
39	Xanthomatosis (HP:0000991)	2.35308993
40	Acute encephalopathy (HP:0006846)	2.33983023
41	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.28984209
42	True hermaphroditism (HP:0010459)	2.28510837
43	Nephronophthisis (HP:0000090)	2.27981056
44	Abnormality of the intrinsic pathway (HP:0010989)	2.27815488
45	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.21969797
46	Optic nerve hypoplasia (HP:0000609)	2.21885552
47	Abnormality of B cell number (HP:0010975)	2.18166794
48	Glomerulonephritis (HP:0000099)	2.16131369
49	Glycosuria (HP:0003076)	2.15306082
50	Abnormality of urine glucose concentration (HP:0011016)	2.15306082
51	Abolished electroretinogram (ERG) (HP:0000550)	2.15155726
52	Delayed CNS myelination (HP:0002188)	2.14251162
53	Metaphyseal dysplasia (HP:0100255)	2.13536521
54	Hypochromic microcytic anemia (HP:0004840)	2.13430486
55	Dyskinesia (HP:0100660)	2.13147749
56	Abnormality of the common coagulation pathway (HP:0010990)	2.10136799
57	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.09958896
58	Medial flaring of the eyebrow (HP:0010747)	2.08358597
59	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07356223
60	Recurrent gram-negative bacterial infections (HP:0005420)	2.07015325
61	Fat malabsorption (HP:0002630)	2.06905295
62	Hyperphosphaturia (HP:0003109)	2.04907353
63	Retinal dysplasia (HP:0007973)	2.03066153
64	Cerebral edema (HP:0002181)	2.02662171
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.01840580
66	Abnormality of alanine metabolism (HP:0010916)	2.01840580
67	Hyperalaninemia (HP:0003348)	2.01840580
68	Renal cortical cysts (HP:0000803)	2.01829094
69	Broad-based gait (HP:0002136)	2.00985555
70	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.00959670
71	Lethargy (HP:0001254)	2.00102323
72	Epidermoid cyst (HP:0200040)	1.97504181
73	Pancreatic cysts (HP:0001737)	1.95842700
74	Volvulus (HP:0002580)	1.94365070
75	Abnormality of the fovea (HP:0000493)	1.92028071
76	Abnormality of nucleobase metabolism (HP:0010932)	1.85571010
77	Hypolipoproteinemia (HP:0010981)	1.84524953
78	Generalized aminoaciduria (HP:0002909)	1.83129207
79	Neonatal hypoglycemia (HP:0001998)	1.82844134
80	Abnormality of vitamin metabolism (HP:0100508)	1.82776928
81	Abnormality of the renal cortex (HP:0011035)	1.82067400
82	Abnormality of the renal medulla (HP:0100957)	1.82002097
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81633506
84	Optic disc pallor (HP:0000543)	1.79728990
85	Hyperammonemia (HP:0001987)	1.79686317
86	Neonatal respiratory distress (HP:0002643)	1.79340988
87	Progressive macrocephaly (HP:0004481)	1.78007315
88	Acute necrotizing encephalopathy (HP:0006965)	1.77722862
89	Pendular nystagmus (HP:0012043)	1.77394469
90	Methylmalonic aciduria (HP:0012120)	1.77309477
91	Pulmonary embolism (HP:0002204)	1.76621428
92	Hypoproteinemia (HP:0003075)	1.76437275
93	Metabolic acidosis (HP:0001942)	1.74309495
94	Ketosis (HP:0001946)	1.73496534
95	Increased serum pyruvate (HP:0003542)	1.73349832
96	Bony spicule pigmentary retinopathy (HP:0007737)	1.73080256
97	Enlarged kidneys (HP:0000105)	1.72649872
98	Type II lissencephaly (HP:0007260)	1.72247733
99	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71998946
100	Cerebellar dysplasia (HP:0007033)	1.71851369

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.11292752
2	ZAK	3.39834503
3	PINK1	3.08840961
4	CASK	3.06535875
5	WNK3	2.63695971
6	TXK	2.44952614
7	DYRK3	2.44482230
8	NUAK1	2.34021401
9	FGFR2	2.27908475
10	WNK4	2.17369695
11	TLK1	1.87052591
12	TAF1	1.86862962
13	MAP2K7	1.84337549
14	NTRK3	1.84124728
15	STK16	1.82923597
16	EPHA3	1.79156085
17	MUSK	1.77775991
18	PIK3CG	1.75554669
19	CAMKK2	1.72943564
20	MARK1	1.69998443
21	EIF2AK3	1.62961434
22	MAP3K4	1.52932918
23	MAPK13	1.52561509
24	TAOK3	1.51366519
25	ADRBK2	1.48593924
26	BCR	1.41014487
27	BMPR1B	1.39805110
28	PAK3	1.39135289
29	DYRK2	1.28574330
30	MAP4K2	1.21679562
31	BCKDK	1.20134623
32	VRK1	1.19933486
33	PIK3CA	1.18475597
34	TIE1	1.02111611
35	INSRR	0.99638064
36	PBK	0.99260963
37	IRAK1	0.94482689
38	GRK6	0.93362549
39	ICK	0.91920159
40	ACVR1B	0.88264064
41	CSNK1G2	0.88243204
42	TRIM28	0.85721436
43	BRSK2	0.82789039
44	FES	0.81158732
45	TYRO3	0.81051132
46	PRKCG	0.80410265
47	DYRK1A	0.79895833
48	EPHA4	0.79306522
49	MAP3K12	0.79289533
50	KIT	0.78262805
51	MAP2K4	0.77944513
52	PRKCE	0.77792845
53	NLK	0.77574328
54	STK39	0.76072713
55	PRKACA	0.74480430
56	STK38L	0.70929090
57	ITK	0.70908895
58	DAPK2	0.70041619
59	MAP3K7	0.65956759
60	PRKACG	0.65124821
61	GRK1	0.64909853
62	SGK2	0.59867890
63	RPS6KA6	0.59694849
64	FGFR3	0.58293957
65	ERBB3	0.58086608
66	OXSR1	0.57903647
67	PKN1	0.57143228
68	STK11	0.55921807
69	VRK2	0.54815820
70	CSNK1G1	0.54752518
71	STK3	0.53030057
72	MAPK15	0.52899924
73	AKT3	0.52500355
74	PRKG1	0.51032926
75	TEC	0.50021499
76	PRKACB	0.49556791
77	MARK3	0.49520239
78	RPS6KA5	0.49038477
79	OBSCN	0.45822947
80	CSNK1G3	0.44226583
81	PRKCQ	0.43618260
82	RPS6KL1	0.43582490
83	RPS6KC1	0.43582490
84	SGK223	0.42931998
85	SGK494	0.42931998
86	CCNB1	0.42491685
87	MAPK4	0.40750634
88	CAMKK1	0.40393096
89	PRKCA	0.40089491
90	CSNK1D	0.40080393
91	MAPK11	0.39897906
92	BTK	0.39877110
93	TNIK	0.39336293
94	ABL2	0.39212329
95	ERBB2	0.39147196
96	MAP2K2	0.38209789
97	IKBKE	0.37572862
98	CDK5	0.37385709
99	PLK3	0.36469124
100	PLK2	0.35661110

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.24600768
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.12507583
3	Caffeine metabolism_Homo sapiens_hsa00232	3.64456307
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.25157584
5	Retinol metabolism_Homo sapiens_hsa00830	3.21155872
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.12382137
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.11434633
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.98385765
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.72178881
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.64921602
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.60414682
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31567393
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30338917
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.19045432
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.18434502
16	Butanoate metabolism_Homo sapiens_hsa00650	2.16052168
17	Arginine biosynthesis_Homo sapiens_hsa00220	2.08292241
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98157273
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.96985674
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.92615519
21	Fatty acid degradation_Homo sapiens_hsa00071	1.92170023
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.84945789
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.84814740
24	Bile secretion_Homo sapiens_hsa04976	1.66896164
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58412701
26	Peroxisome_Homo sapiens_hsa04146	1.50903426
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.49566467
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.48148777
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.43066757
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14757384
31	Histidine metabolism_Homo sapiens_hsa00340	1.13954357
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10062954
33	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.07016521
34	Sulfur relay system_Homo sapiens_hsa04122	1.05839017
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05074588
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95243020
37	PPAR signaling pathway_Homo sapiens_hsa03320	0.95023044
38	Propanoate metabolism_Homo sapiens_hsa00640	0.94469203
39	Oxidative phosphorylation_Homo sapiens_hsa00190	0.92527286
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89563520
41	One carbon pool by folate_Homo sapiens_hsa00670	0.89412402
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.86884390
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.86106950
44	Parkinsons disease_Homo sapiens_hsa05012	0.85433826
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84475906
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83604892
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83465404
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.77910792
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76952947
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76254717
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.70562605
52	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69515539
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.66507207
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65453115
55	Nicotine addiction_Homo sapiens_hsa05033	0.64374022
56	ABC transporters_Homo sapiens_hsa02010	0.59962593
57	Metabolic pathways_Homo sapiens_hsa01100	0.59306506
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.55511213
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.53422111
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.52777367
61	Basal transcription factors_Homo sapiens_hsa03022	0.50661229
62	Protein export_Homo sapiens_hsa03060	0.49297783
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47758020
64	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47219196
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.46985871
66	Huntingtons disease_Homo sapiens_hsa05016	0.45564924
67	Ribosome_Homo sapiens_hsa03010	0.45240006
68	Folate biosynthesis_Homo sapiens_hsa00790	0.44896439
69	Carbon metabolism_Homo sapiens_hsa01200	0.44094761
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.42161999
71	Serotonergic synapse_Homo sapiens_hsa04726	0.41775278
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39261719
73	Phototransduction_Homo sapiens_hsa04744	0.38134423
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.37393287
75	Alzheimers disease_Homo sapiens_hsa05010	0.35920239
76	Olfactory transduction_Homo sapiens_hsa04740	0.35912606
77	Homologous recombination_Homo sapiens_hsa03440	0.34293496
78	Fatty acid elongation_Homo sapiens_hsa00062	0.31364865
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29063216
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28946104
81	Circadian rhythm_Homo sapiens_hsa04710	0.28270479
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26899282
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.26790796
84	Cocaine addiction_Homo sapiens_hsa05030	0.25064873
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.24640772
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22053252
87	Lysine degradation_Homo sapiens_hsa00310	0.21059848
88	Prion diseases_Homo sapiens_hsa05020	0.20940066
89	GABAergic synapse_Homo sapiens_hsa04727	0.20338548
90	Proteasome_Homo sapiens_hsa03050	0.19738988
91	RNA polymerase_Homo sapiens_hsa03020	0.18145464
92	Mineral absorption_Homo sapiens_hsa04978	0.16794123
93	Taste transduction_Homo sapiens_hsa04742	0.16547271
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.16339006
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.16024069
96	Morphine addiction_Homo sapiens_hsa05032	0.15509008
97	Insulin secretion_Homo sapiens_hsa04911	0.14790713
98	Amphetamine addiction_Homo sapiens_hsa05031	0.13628311
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.13428813
100	Fanconi anemia pathway_Homo sapiens_hsa03460	0.13389426

PLGLA

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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