PLGLB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.60104409
2drug catabolic process (GO:0042737)8.32858274
3omega-hydroxylase P450 pathway (GO:0097267)8.10016924
4epoxygenase P450 pathway (GO:0019373)7.94574423
5glyoxylate metabolic process (GO:0046487)7.57892560
6complement activation, alternative pathway (GO:0006957)7.37639601
7regulation of protein activation cascade (GO:2000257)6.58191069
8regulation of complement activation (GO:0030449)6.22605487
9regulation of fibrinolysis (GO:0051917)6.18100347
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.14898435
11L-phenylalanine catabolic process (GO:0006559)6.14898435
12oxidative demethylation (GO:0070989)5.97918598
13ethanol oxidation (GO:0006069)5.83252990
14negative regulation of fibrinolysis (GO:0051918)5.75482648
15aromatic amino acid family catabolic process (GO:0009074)5.57299172
16drug metabolic process (GO:0017144)5.53456773
17serine family amino acid catabolic process (GO:0009071)5.52219588
18regulation of triglyceride catabolic process (GO:0010896)5.33501638
19L-phenylalanine metabolic process (GO:0006558)5.15880164
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.15880164
21protein carboxylation (GO:0018214)5.10930002
22peptidyl-glutamic acid carboxylation (GO:0017187)5.10930002
23indole-containing compound catabolic process (GO:0042436)5.06099826
24indolalkylamine catabolic process (GO:0046218)5.06099826
25tryptophan catabolic process (GO:0006569)5.06099826
26phenylpropanoid metabolic process (GO:0009698)4.84347869
27bile acid biosynthetic process (GO:0006699)4.82407429
28cellular glucuronidation (GO:0052695)4.73877226
29ethanol metabolic process (GO:0006067)4.71829961
30blood coagulation, intrinsic pathway (GO:0007597)4.65814867
31fibrinolysis (GO:0042730)4.65750258
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63544594
33opsonization (GO:0008228)4.56350154
34S-adenosylmethionine metabolic process (GO:0046500)4.53920160
35negative regulation of cholesterol transport (GO:0032375)4.52405921
36negative regulation of sterol transport (GO:0032372)4.52405921
37alkaloid metabolic process (GO:0009820)4.46384526
38urea metabolic process (GO:0019627)4.45586289
39uronic acid metabolic process (GO:0006063)4.43986498
40glucuronate metabolic process (GO:0019585)4.43986498
41negative regulation of protein activation cascade (GO:2000258)4.43419620
42tryptophan metabolic process (GO:0006568)4.37936694
43protein activation cascade (GO:0072376)4.36137227
44glycine metabolic process (GO:0006544)4.23362714
45complement activation (GO:0006956)4.23330041
46imidazole-containing compound metabolic process (GO:0052803)4.23252557
47pyrimidine nucleobase catabolic process (GO:0006208)4.22731665
48bile acid metabolic process (GO:0008206)4.17388595
49acylglycerol homeostasis (GO:0055090)4.05285873
50triglyceride homeostasis (GO:0070328)4.05285873
51nitrogen cycle metabolic process (GO:0071941)4.03401237
52complement activation, classical pathway (GO:0006958)3.96945750
53cellular ketone body metabolic process (GO:0046950)3.93730568
54regulation of humoral immune response (GO:0002920)3.91178655
55bile acid and bile salt transport (GO:0015721)3.89783513
56arginine metabolic process (GO:0006525)3.81802492
57regulation of plasminogen activation (GO:0010755)3.81505906
58tyrosine metabolic process (GO:0006570)3.78631917
59acute-phase response (GO:0006953)3.77191454
60aromatic amino acid family metabolic process (GO:0009072)3.76126198
61cytolysis (GO:0019835)3.73549559
62negative regulation of complement activation (GO:0045916)3.71382744
63disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.69998200
64killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.69998200
65alpha-amino acid catabolic process (GO:1901606)3.63044141
66indolalkylamine metabolic process (GO:0006586)3.60614780
67coenzyme catabolic process (GO:0009109)3.58329272
68nucleobase catabolic process (GO:0046113)3.57376116
69negative regulation of hemostasis (GO:1900047)3.57144970
70negative regulation of blood coagulation (GO:0030195)3.57144970
71amino-acid betaine metabolic process (GO:0006577)3.56961778
72high-density lipoprotein particle remodeling (GO:0034375)3.54243293
73urea cycle (GO:0000050)3.52395444
74protein-lipid complex remodeling (GO:0034368)3.52156147
75macromolecular complex remodeling (GO:0034367)3.52156147
76plasma lipoprotein particle remodeling (GO:0034369)3.52156147
77arginine catabolic process (GO:0006527)3.48625725
78phospholipid efflux (GO:0033700)3.48395116
79positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.47230208
80kynurenine metabolic process (GO:0070189)3.44536039
81ketone body metabolic process (GO:1902224)3.40746578
82amine catabolic process (GO:0009310)3.35258867
83cellular biogenic amine catabolic process (GO:0042402)3.35258867
84serine family amino acid metabolic process (GO:0009069)3.34502765
85reverse cholesterol transport (GO:0043691)3.32962426
86positive regulation of triglyceride lipase activity (GO:0061365)3.32292098
87positive regulation of lipoprotein lipase activity (GO:0051006)3.32292098
88flavonoid metabolic process (GO:0009812)3.30976503
89cholesterol efflux (GO:0033344)3.28756009
90intestinal cholesterol absorption (GO:0030299)3.23623198
91negative regulation of lipase activity (GO:0060192)3.22426078
92heme transport (GO:0015886)3.21503376
93sodium-independent organic anion transport (GO:0043252)3.21315667
94glutamate metabolic process (GO:0006536)3.18882804
95positive regulation of blood coagulation (GO:0030194)3.18152089
96positive regulation of hemostasis (GO:1900048)3.18152089
97negative regulation of wound healing (GO:0061045)3.17396712
98negative regulation of coagulation (GO:0050819)3.08802035
99xenobiotic catabolic process (GO:0042178)3.06421796
100peptidyl-glutamic acid modification (GO:0018200)3.04215059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65751146
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.47682158
3EZH2_22144423_ChIP-Seq_EOC_Human2.94718117
4GBX2_23144817_ChIP-Seq_PC3_Human2.93038920
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66126800
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29400585
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.20324030
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.15823247
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08888817
10TAF15_26573619_Chip-Seq_HEK293_Human2.08851114
11IGF1R_20145208_ChIP-Seq_DFB_Human2.06594617
12VDR_22108803_ChIP-Seq_LS180_Human2.00473004
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99281707
14ZNF274_21170338_ChIP-Seq_K562_Hela1.96329559
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92694886
16ER_23166858_ChIP-Seq_MCF-7_Human1.83833218
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79565264
18BCAT_22108803_ChIP-Seq_LS180_Human1.77144449
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74727333
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74258319
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73997276
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70507324
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68864489
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61483676
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.60778676
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59357717
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58874563
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58874563
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55857509
30IRF1_19129219_ChIP-ChIP_H3396_Human1.55503261
31P300_19829295_ChIP-Seq_ESCs_Human1.54924781
32STAT3_23295773_ChIP-Seq_U87_Human1.53509929
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52967226
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51612824
35CBP_20019798_ChIP-Seq_JUKART_Human1.51612824
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48399468
37FUS_26573619_Chip-Seq_HEK293_Human1.47767194
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45686496
39SMAD4_21799915_ChIP-Seq_A2780_Human1.39279302
40TCF4_23295773_ChIP-Seq_U87_Human1.38273914
41TP53_16413492_ChIP-PET_HCT116_Human1.37453398
42AR_25329375_ChIP-Seq_VCAP_Human1.37118762
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.36997850
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35400762
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33753697
46HTT_18923047_ChIP-ChIP_STHdh_Human1.32458121
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30566426
48REST_21632747_ChIP-Seq_MESCs_Mouse1.28164802
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28123591
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27783904
51* RUNX2_22187159_ChIP-Seq_PCA_Human1.27528437
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27401236
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.27289832
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26436340
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.24987208
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23722236
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21728371
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21448332
59TCF4_22108803_ChIP-Seq_LS180_Human1.21005642
60AR_21572438_ChIP-Seq_LNCaP_Human1.20364294
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18340173
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16289030
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14585202
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.13233792
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.13007504
66DROSHA_22980978_ChIP-Seq_HELA_Human1.12751537
67* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11615382
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10146149
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09773986
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09769895
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09010659
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08909628
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08777954
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.08701194
75NANOG_19829295_ChIP-Seq_ESCs_Human1.08315030
76SOX2_19829295_ChIP-Seq_ESCs_Human1.08315030
77CDX2_22108803_ChIP-Seq_LS180_Human1.07056981
78TBL1_22424771_ChIP-Seq_293T_Human1.06738329
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06149726
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05889221
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.05861638
82* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05739985
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05563638
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.04179767
85EWS_26573619_Chip-Seq_HEK293_Human1.02719050
86P53_22387025_ChIP-Seq_ESCs_Mouse1.02140989
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.02088599
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01811657
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.01160944
90NFYA_21822215_ChIP-Seq_K562_Human1.00209309
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98644125
92NFYB_21822215_ChIP-Seq_K562_Human0.98382023
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98230770
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.97678153
95RNF2_27304074_Chip-Seq_NSC_Mouse0.96983247
96ETV1_20927104_ChIP-Seq_GIST48_Human0.96782258
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96016673
98PHF8_20622853_ChIP-Seq_HELA_Human0.95769539
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95205062
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95109084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.86702703
2MP0005360_urolithiasis5.08070962
3MP0003195_calcinosis4.95864682
4MP0005085_abnormal_gallbladder_physiolo4.84601486
5MP0008875_abnormal_xenobiotic_pharmacok4.72725885
6MP0002138_abnormal_hepatobiliary_system4.03345097
7MP0005365_abnormal_bile_salt3.79474140
8MP0003252_abnormal_bile_duct3.37777951
9MP0002876_abnormal_thyroid_physiology2.74181561
10MP0010329_abnormal_lipoprotein_level2.25534006
11MP0003880_abnormal_central_pattern2.14062593
12MP0001666_abnormal_nutrient_absorption2.11563217
13MP0009697_abnormal_copulation1.96590035
14MP0003787_abnormal_imprinting1.95759787
15MP0003868_abnormal_feces_composition1.91111603
16MP0005332_abnormal_amino_acid1.85047188
17MP0001764_abnormal_homeostasis1.69790273
18MP0006292_abnormal_olfactory_placode1.69548830
19MP0004142_abnormal_muscle_tone1.63217924
20MP0003122_maternal_imprinting1.56821739
21MP0009764_decreased_sensitivity_to1.53333689
22MP0006276_abnormal_autonomic_nervous1.49704885
23MP0005551_abnormal_eye_electrophysiolog1.45711510
24MP0002118_abnormal_lipid_homeostasis1.35295488
25MP0009745_abnormal_behavioral_response1.28830589
26MP0008877_abnormal_DNA_methylation1.21893755
27MP0000609_abnormal_liver_physiology1.20380626
28MP0003121_genomic_imprinting1.18620117
29MP0008872_abnormal_physiological_respon1.16867857
30MP0001440_abnormal_grooming_behavior1.14856322
31MP0005423_abnormal_somatic_nervous1.13495671
32MP0002102_abnormal_ear_morphology1.11635112
33MP0002272_abnormal_nervous_system1.10804702
34MP0001986_abnormal_taste_sensitivity1.05839446
35MP0001486_abnormal_startle_reflex1.05455753
36MP0010368_abnormal_lymphatic_system1.04013438
37MP0009046_muscle_twitch1.02667185
38MP0005646_abnormal_pituitary_gland1.01425522
39MP0002928_abnormal_bile_duct1.01201682
40MP0003646_muscle_fatigue0.97022021
41MP0009840_abnormal_foam_cell0.95970028
42MP0003191_abnormal_cellular_cholesterol0.94764093
43MP0001968_abnormal_touch/_nociception0.94358151
44MP0004130_abnormal_muscle_cell0.93945685
45MP0004742_abnormal_vestibular_system0.93349512
46MP0003656_abnormal_erythrocyte_physiolo0.91256525
47MP0003879_abnormal_hair_cell0.89709368
48MP0000569_abnormal_digit_pigmentation0.88716614
49MP0002168_other_aberrant_phenotype0.88707413
50MP0003878_abnormal_ear_physiology0.87859939
51MP0005377_hearing/vestibular/ear_phenot0.87859939
52MP0002638_abnormal_pupillary_reflex0.85993928
53MP0002971_abnormal_brown_adipose0.85570669
54MP0002132_abnormal_respiratory_system0.84471883
55MP0002064_seizures0.83911124
56MP0003635_abnormal_synaptic_transmissio0.81878123
57MP0004924_abnormal_behavior0.81559655
58MP0005386_behavior/neurological_phenoty0.81559655
59MP0003633_abnormal_nervous_system0.79140295
60MP0001501_abnormal_sleep_pattern0.78997633
61MP0005376_homeostasis/metabolism_phenot0.74660653
62MP0009115_abnormal_fat_cell0.74621215
63MP0009642_abnormal_blood_homeostasis0.74520289
64MP0004019_abnormal_vitamin_homeostasis0.74416178
65MP0002063_abnormal_learning/memory/cond0.74310799
66MP0000778_abnormal_nervous_system0.72383652
67MP0002067_abnormal_sensory_capabilities0.72261250
68MP0009053_abnormal_anal_canal0.71978991
69MP0002557_abnormal_social/conspecific_i0.71297777
70MP0002078_abnormal_glucose_homeostasis0.71089643
71MP0001485_abnormal_pinna_reflex0.70643248
72MP0000955_abnormal_spinal_cord0.70613330
73MP0003011_delayed_dark_adaptation0.70095198
74MP0004859_abnormal_synaptic_plasticity0.69513232
75MP0005395_other_phenotype0.69109001
76MP0004484_altered_response_of0.69055171
77MP0000230_abnormal_systemic_arterial0.68803836
78MP0000631_abnormal_neuroendocrine_gland0.68341018
79MP0009643_abnormal_urine_homeostasis0.67522113
80MP0002572_abnormal_emotion/affect_behav0.65502987
81MP0005334_abnormal_fat_pad0.65500973
82MP0005195_abnormal_posterior_eye0.65377242
83MP0005584_abnormal_enzyme/coenzyme_acti0.65219708
84MP0002282_abnormal_trachea_morphology0.64713899
85MP0004885_abnormal_endolymph0.63766807
86MP0001502_abnormal_circadian_rhythm0.62691169
87MP0005253_abnormal_eye_physiology0.62648222
88MP0005319_abnormal_enzyme/_coenzyme0.62623288
89MP0005535_abnormal_body_temperature0.61002343
90MP0005670_abnormal_white_adipose0.60945431
91MP0005266_abnormal_metabolism0.59661188
92MP0002653_abnormal_ependyma_morphology0.58993954
93MP0003638_abnormal_response/metabolism_0.58828502
94MP0000427_abnormal_hair_cycle0.58342690
95MP0003631_nervous_system_phenotype0.58012582
96MP0004145_abnormal_muscle_electrophysio0.57651304
97MP0004133_heterotaxia0.56615475
98MP0005448_abnormal_energy_balance0.56248863
99MP0003123_paternal_imprinting0.55533902
100MP0000639_abnormal_adrenal_gland0.55501403

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)7.55011262
2Prolonged partial thromboplastin time (HP:0003645)6.78274551
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.76171881
4Deep venous thrombosis (HP:0002625)6.39732773
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.11625118
6Hypobetalipoproteinemia (HP:0003563)5.93000788
7Abnormality of complement system (HP:0005339)5.55508813
8Conjugated hyperbilirubinemia (HP:0002908)5.53624745
9Hyperlipoproteinemia (HP:0010980)5.40753112
10Joint hemorrhage (HP:0005261)4.60588770
11Systemic lupus erythematosus (HP:0002725)4.22008692
12Spontaneous abortion (HP:0005268)3.97242285
13Chronic hepatic failure (HP:0100626)3.83370965
14Intrahepatic cholestasis (HP:0001406)3.71914596
15Xanthomatosis (HP:0000991)3.71612528
16Glomerulonephritis (HP:0000099)3.62917819
17Recurrent gram-negative bacterial infections (HP:0005420)3.59633056
18Fair hair (HP:0002286)3.42808939
19Hypolipoproteinemia (HP:0010981)3.37582282
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32082186
21Hyperglycinemia (HP:0002154)3.28647789
22Abnormality of pyrimidine metabolism (HP:0004353)3.11870244
23Abnormality of the intrinsic pathway (HP:0010989)3.01570728
24Abnormality of the common coagulation pathway (HP:0010990)2.99158443
25Epidermoid cyst (HP:0200040)2.98110640
26Abnormality of methionine metabolism (HP:0010901)2.87966065
27Delayed CNS myelination (HP:0002188)2.82874301
28Thyroid-stimulating hormone excess (HP:0002925)2.82041592
29Nephritis (HP:0000123)2.73691578
30Neonatal hypoglycemia (HP:0001998)2.72875158
31Abnormality of glycine metabolism (HP:0010895)2.69930890
32Abnormality of serine family amino acid metabolism (HP:0010894)2.69930890
33Osteomalacia (HP:0002749)2.65030712
34Bile duct proliferation (HP:0001408)2.56445399
35Abnormal biliary tract physiology (HP:0012439)2.56445399
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55014414
37Hypoalphalipoproteinemia (HP:0003233)2.52757069
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48363866
39Generalized hypopigmentation of hair (HP:0011358)2.44188492
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43156937
41Arthropathy (HP:0003040)2.39478874
42Hyperglycinuria (HP:0003108)2.38221516
43Gingival bleeding (HP:0000225)2.36057327
44Ketosis (HP:0001946)2.33180340
45Abnormality of serum amino acid levels (HP:0003112)2.29173971
46Hypochromic microcytic anemia (HP:0004840)2.21761023
47Hyperventilation (HP:0002883)2.18791842
48Nephronophthisis (HP:0000090)2.18097691
49Medial flaring of the eyebrow (HP:0010747)2.12276721
50Pancreatic fibrosis (HP:0100732)2.12210988
51Generalized aminoaciduria (HP:0002909)2.07705323
52Status epilepticus (HP:0002133)2.05855127
53True hermaphroditism (HP:0010459)2.05435317
54Pulmonary embolism (HP:0002204)2.03041560
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.00964616
56Abnormal rod and cone electroretinograms (HP:0008323)2.00311826
57Gaze-evoked nystagmus (HP:0000640)1.99157907
58Poikilocytosis (HP:0004447)1.97837963
59Mitral stenosis (HP:0001718)1.97591692
60Dyskinesia (HP:0100660)1.97391427
61Thrombophlebitis (HP:0004418)1.96945839
62Pigmentary retinal degeneration (HP:0001146)1.94977386
63Abnormality of midbrain morphology (HP:0002418)1.94665762
64Molar tooth sign on MRI (HP:0002419)1.94665762
65Abnormality of nucleobase metabolism (HP:0010932)1.93415346
66Fat malabsorption (HP:0002630)1.91506533
67Focal seizures (HP:0007359)1.91358976
68Epileptic encephalopathy (HP:0200134)1.91041943
69Hyperammonemia (HP:0001987)1.88943423
70Abnormality of the renal cortex (HP:0011035)1.87258424
71Hyperbilirubinemia (HP:0002904)1.86705686
72Gait imbalance (HP:0002141)1.86523045
73Abnormality of alanine metabolism (HP:0010916)1.86325329
74Hyperalaninemia (HP:0003348)1.86325329
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86325329
76Abnormality of the renal medulla (HP:0100957)1.84744151
77Febrile seizures (HP:0002373)1.81738943
78Reduced antithrombin III activity (HP:0001976)1.80546508
79Pancreatic cysts (HP:0001737)1.80494531
80Enlarged kidneys (HP:0000105)1.78543639
81Hypercholesterolemia (HP:0003124)1.78161162
82Type II lissencephaly (HP:0007260)1.75567263
83Polyphagia (HP:0002591)1.71796355
84Congenital primary aphakia (HP:0007707)1.71716423
85Hypothermia (HP:0002045)1.70494773
86Abnormality of vitamin metabolism (HP:0100508)1.69339726
87Absent/shortened dynein arms (HP:0200106)1.68188040
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.68188040
89Metabolic acidosis (HP:0001942)1.65728937
90Progressive cerebellar ataxia (HP:0002073)1.65661309
91Poor coordination (HP:0002370)1.65383990
92Bony spicule pigmentary retinopathy (HP:0007737)1.64082905
93Nephrogenic diabetes insipidus (HP:0009806)1.63440079
94Broad-based gait (HP:0002136)1.62352623
95Intestinal atresia (HP:0011100)1.60639094
96Drooling (HP:0002307)1.60323928
97Thyroiditis (HP:0100646)1.60001787
98Rickets (HP:0002748)1.59841684
99Blue irides (HP:0000635)1.56457963
100Congenital stationary night blindness (HP:0007642)1.56312098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.44005703
2PINK13.01350642
3ADRBK22.61797788
4MAP4K22.47968930
5TAOK32.38889864
6MAP3K42.21804274
7TRIM282.21150208
8MAP2K72.09661037
9CAMKK22.02928319
10NTRK31.93717497
11SGK21.82036271
12CASK1.64058271
13SGK4941.62042502
14SGK2231.62042502
15WNK31.61946302
16MAPK131.51247018
17CAMK1D1.50521540
18MARK11.49605007
19PIK3CA1.48220467
20SIK21.45396310
21EPHA41.43110680
22MARK31.41309613
23PAK31.41242053
24BLK1.40349517
25STK161.38774429
26CAMK1G1.36826866
27MAP2K41.36130449
28GRK11.33331367
29IRAK11.30710271
30AKT31.26960544
31BMPR1B1.21845212
32DAPK21.17415206
33DYRK31.15337001
34PRKCG1.14188974
35NUAK11.10056437
36SGK31.08932378
37ACVR1B1.05437198
38DYRK21.04591428
39MAP3K91.04188906
40CAMK41.01788435
41TNK21.01691239
42MKNK20.97511218
43PIK3CG0.93050487
44CAMK10.90793697
45OBSCN0.90631401
46NTRK20.89000413
47IRAK20.87517766
48ERBB20.87517705
49MAP3K60.85464069
50BCR0.84770909
51RPS6KA40.78582798
52PRKCQ0.77896555
53PNCK0.76762342
54CAMKK10.76564326
55TNIK0.74511216
56TXK0.74259103
57LATS10.72311693
58PRKAA20.67291679
59PRKCE0.66421584
60DYRK1A0.65990303
61PRKAA10.65803282
62PRKACG0.65194706
63PRKG10.64605503
64SGK10.64246166
65STK110.63890791
66PKN20.63508612
67INSRR0.62702597
68SIK30.62119471
69TEC0.62034296
70NLK0.61896208
71PDK10.60118961
72IRAK40.60060585
73PRKACA0.59431662
74ITK0.58086335
75ADRBK10.56289377
76PRKCZ0.56286968
77SYK0.54475394
78BTK0.54051669
79MAP3K70.53998581
80IKBKE0.53518702
81MUSK0.53180912
82FES0.52557344
83CSNK1G20.52386868
84FGFR20.52356931
85MAPK120.51420103
86CDK190.51298512
87BCKDK0.50452293
88PKN10.50004133
89RPS6KA60.46245870
90MINK10.46131310
91ZAK0.45725102
92PTK2B0.45084056
93CSNK1G10.41495020
94BRSK20.39662816
95RPS6KA30.39186190
96FGFR30.38999931
97CDK30.38845953
98RPS6KA50.37921461
99EPHA30.37832705
100RPS6KA20.37649102

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.46302537
2Complement and coagulation cascades_Homo sapiens_hsa046103.68110221
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.62194889
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.60176320
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.42505307
6Retinol metabolism_Homo sapiens_hsa008303.33835835
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24668104
8Chemical carcinogenesis_Homo sapiens_hsa052042.94512656
9Linoleic acid metabolism_Homo sapiens_hsa005912.69470350
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.67484012
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.64988430
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54107159
13Butanoate metabolism_Homo sapiens_hsa006502.53103559
14Fatty acid degradation_Homo sapiens_hsa000712.52403535
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28972498
16Arginine biosynthesis_Homo sapiens_hsa002202.20975385
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16669621
18Tryptophan metabolism_Homo sapiens_hsa003802.00383273
19Phenylalanine metabolism_Homo sapiens_hsa003601.96030643
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.93363641
21Tyrosine metabolism_Homo sapiens_hsa003501.93081796
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88337122
23Histidine metabolism_Homo sapiens_hsa003401.84766979
24Bile secretion_Homo sapiens_hsa049761.55568466
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52591830
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51211009
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45891485
28Arachidonic acid metabolism_Homo sapiens_hsa005901.44527528
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40322618
30Peroxisome_Homo sapiens_hsa041461.35245892
31beta-Alanine metabolism_Homo sapiens_hsa004101.32989796
32Starch and sucrose metabolism_Homo sapiens_hsa005001.22913809
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20659907
34Propanoate metabolism_Homo sapiens_hsa006401.18657133
35PPAR signaling pathway_Homo sapiens_hsa033201.12627757
36ABC transporters_Homo sapiens_hsa020101.12485654
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10665058
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.04106954
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99957925
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99235675
41Prion diseases_Homo sapiens_hsa050200.91815356
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.91356292
43Arginine and proline metabolism_Homo sapiens_hsa003300.86968062
44Fat digestion and absorption_Homo sapiens_hsa049750.76748035
45Sulfur relay system_Homo sapiens_hsa041220.72276801
46Pyruvate metabolism_Homo sapiens_hsa006200.65971422
47Serotonergic synapse_Homo sapiens_hsa047260.59340334
48Glycerolipid metabolism_Homo sapiens_hsa005610.58787103
49Nicotine addiction_Homo sapiens_hsa050330.58015026
50Lysine degradation_Homo sapiens_hsa003100.56215753
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.55635303
52Fatty acid metabolism_Homo sapiens_hsa012120.54194611
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54136128
54Ether lipid metabolism_Homo sapiens_hsa005650.51217059
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50844766
56Glucagon signaling pathway_Homo sapiens_hsa049220.41511095
57One carbon pool by folate_Homo sapiens_hsa006700.41177610
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38409996
59Circadian rhythm_Homo sapiens_hsa047100.37826372
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35139163
61Morphine addiction_Homo sapiens_hsa050320.33784066
62Metabolic pathways_Homo sapiens_hsa011000.33714116
63Ovarian steroidogenesis_Homo sapiens_hsa049130.33623434
64Cocaine addiction_Homo sapiens_hsa050300.33261948
65Biosynthesis of amino acids_Homo sapiens_hsa012300.33134956
66Nitrogen metabolism_Homo sapiens_hsa009100.32864332
67Phototransduction_Homo sapiens_hsa047440.31039314
68Insulin resistance_Homo sapiens_hsa049310.29687147
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29181452
70Olfactory transduction_Homo sapiens_hsa047400.27826015
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27761767
72GABAergic synapse_Homo sapiens_hsa047270.24822870
73Selenocompound metabolism_Homo sapiens_hsa004500.24571157
74Glutamatergic synapse_Homo sapiens_hsa047240.23905038
75Insulin secretion_Homo sapiens_hsa049110.23763294
76Taste transduction_Homo sapiens_hsa047420.20707339
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.20701573
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18699065
79Regulation of autophagy_Homo sapiens_hsa041400.18324448
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.18085471
81Circadian entrainment_Homo sapiens_hsa047130.17036234
82Long-term depression_Homo sapiens_hsa047300.15865353
83Vitamin B6 metabolism_Homo sapiens_hsa007500.14556143
84Dorso-ventral axis formation_Homo sapiens_hsa043200.14339366
85Dopaminergic synapse_Homo sapiens_hsa047280.12126914
86Amphetamine addiction_Homo sapiens_hsa050310.10458598
87FoxO signaling pathway_Homo sapiens_hsa040680.10181262
88Mineral absorption_Homo sapiens_hsa049780.08180890
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.07795379
90Type II diabetes mellitus_Homo sapiens_hsa049300.07741952
91AMPK signaling pathway_Homo sapiens_hsa041520.07735806
92Pertussis_Homo sapiens_hsa051330.07309831
93Renin secretion_Homo sapiens_hsa049240.06619535
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.05729746
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.04725237
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.02954010
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01409181
98Carbon metabolism_Homo sapiens_hsa012000.00716680
99Fatty acid biosynthesis_Homo sapiens_hsa000610.00318260
100Salivary secretion_Homo sapiens_hsa04970-0.0029804

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