PLGRKT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)8.86823221
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)8.82452437
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)8.82452437
4folic acid-containing compound biosynthetic process (GO:0009396)8.08366284
5purine nucleotide salvage (GO:0032261)8.03934606
6sulfur amino acid catabolic process (GO:0000098)7.87571152
7adenosine metabolic process (GO:0046085)7.25499799
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.86059831
9cysteine metabolic process (GO:0006534)6.64754299
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.74386093
11pteridine-containing compound biosynthetic process (GO:0042559)5.61680575
12white fat cell differentiation (GO:0050872)5.55058354
13regulation of vitamin D biosynthetic process (GO:0060556)5.50334729
14negative regulation of DNA biosynthetic process (GO:2000279)5.43159924
15microtubule nucleation (GO:0007020)5.38398892
16mitochondrial RNA metabolic process (GO:0000959)5.13876301
17L-serine metabolic process (GO:0006563)5.07534150
18ribosomal small subunit assembly (GO:0000028)4.82660174
19galactose catabolic process (GO:0019388)4.77728629
20regulation of vitamin metabolic process (GO:0030656)4.65211487
21IMP biosynthetic process (GO:0006188)4.60897807
22purine-containing compound salvage (GO:0043101)4.59158546
23positive regulation of endothelial cell differentiation (GO:0045603)4.57575961
24inner ear receptor cell development (GO:0060119)4.56653872
25protein-cofactor linkage (GO:0018065)4.49945689
26positive regulation of gamma-delta T cell activation (GO:0046645)4.47617127
27nucleotide salvage (GO:0043173)4.43945164
28desmosome organization (GO:0002934)4.41619521
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39340168
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39340168
31negative regulation of Ras GTPase activity (GO:0034261)4.33367609
32alternative mRNA splicing, via spliceosome (GO:0000380)4.33329425
33antigen processing and presentation of endogenous antigen (GO:0019883)4.32359304
34neutrophil activation involved in immune response (GO:0002283)4.25830574
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.25033929
36NADH dehydrogenase complex assembly (GO:0010257)4.25033929
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25033929
38serine family amino acid biosynthetic process (GO:0009070)4.22506788
39galactose metabolic process (GO:0006012)4.15220415
40regulation of gonadotropin secretion (GO:0032276)4.14792432
41tetrahydrofolate metabolic process (GO:0046653)4.10280213
42protein-chromophore linkage (GO:0018298)4.09230665
43cartilage morphogenesis (GO:0060536)4.06110453
44rRNA methylation (GO:0031167)4.02144466
45folic acid-containing compound metabolic process (GO:0006760)4.02088305
46cell migration involved in heart development (GO:0060973)3.99092522
47IMP metabolic process (GO:0046040)3.94485517
48regulation of sequestering of triglyceride (GO:0010889)3.90818017
49rRNA modification (GO:0000154)3.89899807
50CENP-A containing nucleosome assembly (GO:0034080)3.86520751
51pseudouridine synthesis (GO:0001522)3.83074580
52regulation of tight junction assembly (GO:2000810)3.80806195
53response to interferon-beta (GO:0035456)3.80121166
54regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.79970340
55negative regulation of telomerase activity (GO:0051974)3.76359273
56negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.74961225
57polyamine biosynthetic process (GO:0006596)3.72494304
58protein complex biogenesis (GO:0070271)3.65153480
59myeloid dendritic cell activation (GO:0001773)3.62864846
60regulation of T-helper 1 cell differentiation (GO:0045625)3.62345934
61aminoglycoside antibiotic metabolic process (GO:0030647)3.61804976
62phosphatidylglycerol biosynthetic process (GO:0006655)3.61800363
63tRNA modification (GO:0006400)3.58888494
64chromatin remodeling at centromere (GO:0031055)3.57643274
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55130234
66response to type I interferon (GO:0034340)3.55082436
67sulfur amino acid biosynthetic process (GO:0000097)3.53870275
68type I interferon signaling pathway (GO:0060337)3.53784945
69cellular response to type I interferon (GO:0071357)3.53784945
70cochlea development (GO:0090102)3.52327543
71antigen processing and presentation via MHC class Ib (GO:0002475)3.51433859
72mast cell activation (GO:0045576)3.47161653
73polyamine metabolic process (GO:0006595)3.46873035
74defense response to protozoan (GO:0042832)3.46054119
75folic acid transport (GO:0015884)3.45116189
76histone H4-K12 acetylation (GO:0043983)3.43260423
77negative regulation of keratinocyte proliferation (GO:0010839)3.41012594
78positive regulation of B cell differentiation (GO:0045579)3.40614642
79cellular response to interferon-beta (GO:0035458)3.39357061
80glycoside metabolic process (GO:0016137)3.38820755
81granulocyte activation (GO:0036230)3.36724355
82negative regulation of catenin import into nucleus (GO:0035414)3.35659088
83myeloid dendritic cell differentiation (GO:0043011)3.34822996
84inner mitochondrial membrane organization (GO:0007007)3.34778888
85viral transcription (GO:0019083)3.34568814
86pteridine-containing compound metabolic process (GO:0042558)3.33734176
87tRNA processing (GO:0008033)3.32316422
88positive regulation of interferon-alpha production (GO:0032727)3.30107826
89immunoglobulin mediated immune response (GO:0016064)3.29108262
90neutrophil activation (GO:0042119)3.28105197
91response to interferon-alpha (GO:0035455)3.27030363
92serine family amino acid catabolic process (GO:0009071)3.27016705
93respiratory burst (GO:0045730)3.25654278
94regulation of B cell receptor signaling pathway (GO:0050855)3.25366104
95response to protozoan (GO:0001562)3.25087492
96response to peptidoglycan (GO:0032494)3.25050994
97mitochondrial respiratory chain complex assembly (GO:0033108)3.23784745
98ATP hydrolysis coupled proton transport (GO:0015991)3.23362891
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23362891
100T cell migration (GO:0072678)3.20683773
101negative regulation of interleukin-1 beta production (GO:0032691)3.20428572
102sulfur amino acid metabolic process (GO:0000096)3.19699389
103Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19678304
104organic cation transport (GO:0015695)3.19420487
105primary amino compound metabolic process (GO:1901160)3.19217079
106nucleoside transmembrane transport (GO:1901642)3.17488922
107regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16765602
108definitive hemopoiesis (GO:0060216)3.16078672
109regulation of endothelial cell differentiation (GO:0045601)3.15161272
110regulation of interferon-alpha production (GO:0032647)3.13249747
111leukocyte aggregation (GO:0070486)3.11790466
112cellular response to zinc ion (GO:0071294)3.11770055
113translational termination (GO:0006415)3.10839051
114regulation of B cell differentiation (GO:0045577)3.09228476
115positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08452489
116guanosine-containing compound biosynthetic process (GO:1901070)3.07890290
117GMP metabolic process (GO:0046037)3.06133741
118DNA ligation (GO:0006266)3.05503892
119positive regulation of natural killer cell differentiation (GO:0032825)3.04583810
120regulation of interleukin-12 biosynthetic process (GO:0045075)3.04050272
121regulation of gamma-delta T cell differentiation (GO:0045586)3.03833576
122ribosome biogenesis (GO:0042254)3.02105938
123regulation of alpha-beta T cell proliferation (GO:0046640)3.01949980
124ribosomal small subunit biogenesis (GO:0042274)3.01004914
125positive regulation of antigen processing and presentation (GO:0002579)3.00770309
126negative regulation of viral genome replication (GO:0045071)2.99611404
127NIK/NF-kappaB signaling (GO:0038061)2.99157861
128behavioral fear response (GO:0001662)2.98995719
129behavioral defense response (GO:0002209)2.98995719
130regulation of gamma-delta T cell activation (GO:0046643)2.96067453
131negative regulation of acute inflammatory response (GO:0002674)2.93729848
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93678175
133myeloid cell activation involved in immune response (GO:0002275)2.93520284
134one-carbon metabolic process (GO:0006730)2.93484936
135interferon-gamma-mediated signaling pathway (GO:0060333)2.92741169
136acrosome assembly (GO:0001675)2.90821868
137regulation of cholesterol storage (GO:0010885)2.90648723
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90534108
139response to lipoprotein particle (GO:0055094)2.90052164
140positive regulation of macrophage differentiation (GO:0045651)2.88336249
141regulation of interferon-beta biosynthetic process (GO:0045357)2.87709499
142positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87502192
143GTP biosynthetic process (GO:0006183)2.87259089
144interferon-gamma production (GO:0032609)2.86198352
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85798205
146negative thymic T cell selection (GO:0045060)2.84106570
147cotranslational protein targeting to membrane (GO:0006613)2.83073214
148B cell mediated immunity (GO:0019724)2.83013202
149proteasome assembly (GO:0043248)2.82361252
150protein targeting to ER (GO:0045047)2.81445657
151leukocyte degranulation (GO:0043299)2.80749632
152negative regulation of blood vessel endothelial cell migration (GO:0043537)2.80523263
153regulation of telomerase activity (GO:0051972)2.80159501
154B cell receptor signaling pathway (GO:0050853)2.79746217
155negative T cell selection (GO:0043383)2.77884063
156dendritic cell differentiation (GO:0097028)2.77688059
157pathway-restricted SMAD protein phosphorylation (GO:0060389)2.76883612
158platelet dense granule organization (GO:0060155)2.76826197
159response to muramyl dipeptide (GO:0032495)2.76670730
160negative regulation of alcohol biosynthetic process (GO:1902931)2.76195120
161positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75750230
162innervation (GO:0060384)2.75489728
163mature B cell differentiation (GO:0002335)2.75083207
164DNA replication-independent nucleosome organization (GO:0034724)2.75047512
165DNA replication-independent nucleosome assembly (GO:0006336)2.75047512
166regulation of RIG-I signaling pathway (GO:0039535)2.74817140
167histone exchange (GO:0043486)2.73776715
168GPI anchor biosynthetic process (GO:0006506)2.73590103
169preassembly of GPI anchor in ER membrane (GO:0016254)2.72280409
170lymph node development (GO:0048535)2.70839423
171regulation of T cell mediated cytotoxicity (GO:0001914)2.69878336
172T cell homeostasis (GO:0043029)2.69697952
173positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69242368
174myeloid leukocyte activation (GO:0002274)2.68093612
175protein localization to endoplasmic reticulum (GO:0070972)2.67033882
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66837775
177production of molecular mediator involved in inflammatory response (GO:0002532)2.65026881
178positive regulation of interleukin-2 production (GO:0032743)2.64971675
179regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64842033
180regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.62739360
181lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62200432
182regulation of necroptotic process (GO:0060544)2.61153908
183regulation of T cell receptor signaling pathway (GO:0050856)2.61055500
184regulation of antigen processing and presentation (GO:0002577)2.60527884
185I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.59285684
186regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.59107619
187natural killer cell activation (GO:0030101)2.58601467
188monocyte chemotaxis (GO:0002548)2.57262269
189viral life cycle (GO:0019058)2.56922983
190regulation of T-helper 1 type immune response (GO:0002825)2.56753737
191translational elongation (GO:0006414)2.56667682
192T-helper 1 type immune response (GO:0042088)2.55050372
193positive regulation of interleukin-12 production (GO:0032735)2.54640778
194positive regulation of isotype switching (GO:0045830)2.53436005
195positive regulation by organism of defense response of other organism involved in symbiotic interact2.53253863
196modulation by symbiont of host immune response (GO:0052553)2.53253863
197modulation by symbiont of host defense response (GO:0052031)2.53253863
198modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53253863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.75420648
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.97025955
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.54417075
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53671355
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42692580
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71270597
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49518918
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.29497422
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29314115
10SCL_19346495_ChIP-Seq_HPC-7_Human3.18366002
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13679745
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87489018
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.87215644
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86191539
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.80594117
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70476051
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70044983
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67218524
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66833394
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64358630
21VDR_22108803_ChIP-Seq_LS180_Human2.59105960
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.58473294
23SPI1_23547873_ChIP-Seq_NB4_Human2.57853989
24MYB_26560356_Chip-Seq_TH2_Human2.20984040
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19606841
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17996641
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11171329
28RUNX_20019798_ChIP-Seq_JUKART_Human2.10019671
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04242893
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02635458
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse12.0660454
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98861192
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97510672
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.94263826
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94054473
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93046941
37GATA1_22025678_ChIP-Seq_K562_Human1.91516815
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83852179
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.82911051
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77346845
41VDR_24763502_ChIP-Seq_THP-1_Human1.77337264
42MAF_26560356_Chip-Seq_TH1_Human1.77095743
43MYB_26560356_Chip-Seq_TH1_Human1.76654392
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74978286
45ZNF274_21170338_ChIP-Seq_K562_Hela1.73580486
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.72999141
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72056368
48VDR_21846776_ChIP-Seq_THP-1_Human1.70370923
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70311694
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63831148
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.62650621
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62419813
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58348971
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58133993
55GABP_19822575_ChIP-Seq_HepG2_Human1.53711352
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51192375
57ELK1_19687146_ChIP-ChIP_HELA_Human1.50865143
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50179867
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49909081
60CDX2_22108803_ChIP-Seq_LS180_Human1.49303893
61NCOR_22424771_ChIP-Seq_293T_Human1.49231480
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48384249
63TP53_22573176_ChIP-Seq_HFKS_Human1.48377128
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45061691
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44812223
66PU_27001747_Chip-Seq_BMDM_Mouse1.44139217
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40793490
68VDR_23849224_ChIP-Seq_CD4+_Human1.40180052
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40118221
70UTX_26944678_Chip-Seq_JUKART_Human1.36245045
71GATA3_27048872_Chip-Seq_THYMUS_Human1.35302277
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34499013
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33604541
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33321825
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.31714787
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30335070
77MYC_22102868_ChIP-Seq_BL_Human1.30328798
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.29732638
79STAT1_20625510_ChIP-Seq_HELA_Human1.29608724
80SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29551413
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29529909
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26598376
83E2F7_22180533_ChIP-Seq_HELA_Human1.23816589
84SPI1_23127762_ChIP-Seq_K562_Human1.23733369
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21875706
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21289773
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.19546075
88EWS_26573619_Chip-Seq_HEK293_Human1.19470192
89GATA3_26560356_Chip-Seq_TH2_Human1.18909707
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17965795
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17323398
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16159153
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15752268
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15312645
95FOXP3_21729870_ChIP-Seq_TREG_Human1.13654584
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12009334
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11680854
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11534733
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.11391548
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11085419
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10309285
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09203771
103EZH2_22144423_ChIP-Seq_EOC_Human1.08928445
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.08691274
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07926815
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07874217
107MAF_26560356_Chip-Seq_TH2_Human1.06173415
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03683791
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03426168
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99705888
111ERG_20517297_ChIP-Seq_VCAP_Human0.99699675
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99404563
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97688029
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97192714
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96700737
116FUS_26573619_Chip-Seq_HEK293_Human0.96651312
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.95544225
118VDR_24787735_ChIP-Seq_THP-1_Human0.95464322
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94710221
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94615220
121FOXH1_21741376_ChIP-Seq_ESCs_Human0.94526641
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94495016
123XRN2_22483619_ChIP-Seq_HELA_Human0.93529875
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93181316
125MYC_18555785_ChIP-Seq_MESCs_Mouse0.92961899
126TFEB_21752829_ChIP-Seq_HELA_Human0.92549504
127TCF7_22412390_ChIP-Seq_EML_Mouse0.92454498
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92149237
129JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92135109
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91742011
131BCAT_22108803_ChIP-Seq_LS180_Human0.90652251
132P300_19829295_ChIP-Seq_ESCs_Human0.90579412
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89514543
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.89205576
135FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89205576
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.87443739
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86642647
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86242694
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86232074
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.84830012
141TAF2_19829295_ChIP-Seq_ESCs_Human0.83937236
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83847326
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83655374
144AR_20517297_ChIP-Seq_VCAP_Human0.83587528
145ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83069390
146PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82552488
147TP63_17297297_ChIP-ChIP_HaCaT_Human0.82401449
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82331623
149SOX2_19829295_ChIP-Seq_ESCs_Human0.81944040
150NANOG_19829295_ChIP-Seq_ESCs_Human0.81944040
151FLI1_21867929_ChIP-Seq_CD8_Mouse0.81938846
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81788954
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81422832
154KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80539966
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80192261
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.78232858
157NANOG_20526341_ChIP-Seq_ESCs_Human0.78027415
158FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76759824
159CEBPB_22108803_ChIP-Seq_LS180_Human0.76644176
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75924427
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75391400
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.75334931
163ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74761999
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74664940
165CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.74579627
166AR_21909140_ChIP-Seq_LNCAP_Human0.73983991
167E2F1_21310950_ChIP-Seq_MCF-7_Human0.73071957
168DCP1A_22483619_ChIP-Seq_HELA_Human0.72654557
169ETS1_20019798_ChIP-Seq_JURKAT_Human0.71682726
170CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70000009
171ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69606732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.83195009
2MP0001835_abnormal_antigen_presentation4.67375091
3MP0005670_abnormal_white_adipose4.51236779
4MP0005646_abnormal_pituitary_gland4.33577833
5MP0003806_abnormal_nucleotide_metabolis3.87596118
6MP0005671_abnormal_response_to3.77489645
7MP0008995_early_reproductive_senescence3.60154123
8MP0009785_altered_susceptibility_to3.51821470
9MP0002148_abnormal_hypersensitivity_rea3.45958144
10MP0000685_abnormal_immune_system3.42758182
11MP0000013_abnormal_adipose_tissue3.33365371
12MP0003436_decreased_susceptibility_to3.12524304
13MP0005000_abnormal_immune_tolerance3.09945772
14MP0003724_increased_susceptibility_to3.08043303
15MP0002938_white_spotting3.05176741
16MP0002736_abnormal_nociception_after2.94590834
17MP0005025_abnormal_response_to2.89380759
18MP0001800_abnormal_humoral_immune2.87399861
19MP0002452_abnormal_antigen_presenting2.78001863
20MP0005387_immune_system_phenotype2.74137212
21MP0001790_abnormal_immune_system2.74137212
22MP0004885_abnormal_endolymph2.70980320
23MP0002723_abnormal_immune_serum2.70320188
24MP0002419_abnormal_innate_immunity2.68055537
25MP0003763_abnormal_thymus_physiology2.66004015
26MP0002420_abnormal_adaptive_immunity2.61560581
27MP0001819_abnormal_immune_cell2.60881755
28MP0003705_abnormal_hypodermis_morpholog2.51035830
29MP0002166_altered_tumor_susceptibility2.48424082
30MP0001661_extended_life_span2.41060284
31MP0006082_CNS_inflammation2.35386830
32MP0005464_abnormal_platelet_physiology2.35361857
33MP0001764_abnormal_homeostasis2.31336046
34MP0000516_abnormal_urinary_system2.28698624
35MP0005367_renal/urinary_system_phenotyp2.28698624
36MP0002006_tumorigenesis2.28055870
37MP0002398_abnormal_bone_marrow2.25725754
38MP0000716_abnormal_immune_system2.09184596
39MP0001853_heart_inflammation2.06360060
40MP0010155_abnormal_intestine_physiology2.05963909
41MP0002396_abnormal_hematopoietic_system2.05862650
42MP0009333_abnormal_splenocyte_physiolog2.01427290
43MP0002405_respiratory_system_inflammati2.00230364
44MP0005332_abnormal_amino_acid1.98742948
45MP0004185_abnormal_adipocyte_glucose1.97678443
46MP0005174_abnormal_tail_pigmentation1.86980460
47MP0002139_abnormal_hepatobiliary_system1.81552612
48MP0000689_abnormal_spleen_morphology1.81492324
49MP0002722_abnormal_immune_system1.79181933
50MP0001845_abnormal_inflammatory_respons1.78940500
51MP0008872_abnormal_physiological_respon1.78316296
52MP0002429_abnormal_blood_cell1.77801405
53MP0001545_abnormal_hematopoietic_system1.76515162
54MP0005397_hematopoietic_system_phenotyp1.76515162
55MP0004808_abnormal_hematopoietic_stem1.76353843
56MP0004947_skin_inflammation1.68468843
57MP0004043_abnormal_pH_regulation1.63665443
58MP0001533_abnormal_skeleton_physiology1.58590278
59MP0002837_dystrophic_cardiac_calcinosis1.57222847
60MP0001873_stomach_inflammation1.56144382
61MP0001968_abnormal_touch/_nociception1.55268344
62MP0000490_abnormal_crypts_of1.54170886
63MP0003866_abnormal_defecation1.52901982
64MP0000465_gastrointestinal_hemorrhage1.47645072
65MP0008469_abnormal_protein_level1.45432038
66MP0005085_abnormal_gallbladder_physiolo1.43941318
67MP0003786_premature_aging1.42984089
68MP0004510_myositis1.40912286
69MP0005551_abnormal_eye_electrophysiolog1.39703057
70MP0005310_abnormal_salivary_gland1.39015172
71MP0005058_abnormal_lysosome_morphology1.38621134
72MP0000703_abnormal_thymus_morphology1.34013930
73MP0000858_altered_metastatic_potential1.31586190
74MP0006054_spinal_hemorrhage1.31099520
75MP0000647_abnormal_sebaceous_gland1.30858667
76MP0009764_decreased_sensitivity_to1.30699435
77MP0002735_abnormal_chemical_nociception1.29649085
78MP0002009_preneoplasia1.23818789
79MP0003303_peritoneal_inflammation1.22853900
80MP0005253_abnormal_eye_physiology1.22340298
81MP0002933_joint_inflammation1.21877649
82MP0005075_abnormal_melanosome_morpholog1.20327505
83MP0000343_altered_response_to1.17980474
84MP0000026_abnormal_inner_ear1.16552098
85MP0003448_altered_tumor_morphology1.10671263
86MP0002160_abnormal_reproductive_system1.09048941
87MP0009379_abnormal_foot_pigmentation1.05816786
88MP0002998_abnormal_bone_remodeling1.05270551
89MP0003300_gastrointestinal_ulcer1.05019750
90MP0004019_abnormal_vitamin_homeostasis1.04732822
91MP0009643_abnormal_urine_homeostasis1.04583481
92MP0002095_abnormal_skin_pigmentation1.04377658
93MP0001756_abnormal_urination1.03845777
94MP0003252_abnormal_bile_duct1.03162755
95MP0009697_abnormal_copulation0.99879629
96MP0005636_abnormal_mineral_homeostasis0.99577704
97MP0002132_abnormal_respiratory_system0.99274129
98MP0000015_abnormal_ear_pigmentation0.99099720
99MP0006072_abnormal_retinal_apoptosis0.98637192
100MP0001986_abnormal_taste_sensitivity0.97544284
101MP0008875_abnormal_xenobiotic_pharmacok0.97141734
102MP0000534_abnormal_ureter_morphology0.95938380
103MP0003828_pulmonary_edema0.93822644
104MP0002876_abnormal_thyroid_physiology0.93647443
105MP0003186_abnormal_redox_activity0.93407374
106MP0002277_abnormal_respiratory_mucosa0.93176669
107MP0009278_abnormal_bone_marrow0.93159791
108MP0000003_abnormal_adipose_tissue0.91829718
109MP0004147_increased_porphyrin_level0.91234679
110MP0008058_abnormal_DNA_repair0.88046526
111MP0008789_abnormal_olfactory_epithelium0.86509781
112MP0001851_eye_inflammation0.86183590
113MP0005319_abnormal_enzyme/_coenzyme0.85804133
114MP0004133_heterotaxia0.84680444
115MP0005376_homeostasis/metabolism_phenot0.83881934
116MP0002138_abnormal_hepatobiliary_system0.83510552
117MP0000631_abnormal_neuroendocrine_gland0.82895524
118MP0003172_abnormal_lysosome_physiology0.82704218
119MP0001963_abnormal_hearing_physiology0.82019035
120MP0001348_abnormal_lacrimal_gland0.81873036
121MP0003646_muscle_fatigue0.79940299
122MP0005164_abnormal_response_to0.79807165
123MP0005365_abnormal_bile_salt0.78675638
124MP0005390_skeleton_phenotype0.78193629
125MP0002069_abnormal_eating/drinking_beha0.78067292
126MP0000372_irregular_coat_pigmentation0.77453227
127MP0003943_abnormal_hepatobiliary_system0.76562551
128MP0002234_abnormal_pharynx_morphology0.76017713
129MP0002019_abnormal_tumor_incidence0.73912240
130MP0006292_abnormal_olfactory_placode0.73832501
131MP0004782_abnormal_surfactant_physiolog0.72887521
132MP0009763_increased_sensitivity_to0.72793094
133MP0006036_abnormal_mitochondrial_physio0.71902190
134MP0001944_abnormal_pancreas_morphology0.71508651
135MP0003191_abnormal_cellular_cholesterol0.71095492
136MP0004145_abnormal_muscle_electrophysio0.70096773
137MP0003183_abnormal_peptide_metabolism0.69449502
138MP0009765_abnormal_xenobiotic_induced0.69198318
139MP0003795_abnormal_bone_structure0.68970031
140MP0004130_abnormal_muscle_cell0.68809840
141MP0005647_abnormal_sex_gland0.68730568
142MP0008007_abnormal_cellular_replicative0.67820474
143MP0001663_abnormal_digestive_system0.67597811
144MP0008057_abnormal_DNA_replication0.67316286
145MP0005389_reproductive_system_phenotype0.66485485
146MP0000653_abnormal_sex_gland0.64827165
147MP0002163_abnormal_gland_morphology0.63227893
148MP0008873_increased_physiological_sensi0.63182787
149MP0002078_abnormal_glucose_homeostasis0.61759135
150MP0005166_decreased_susceptibility_to0.61356223
151MP0001905_abnormal_dopamine_level0.60740056
152MP0005334_abnormal_fat_pad0.60603529
153MP0002877_abnormal_melanocyte_morpholog0.59955292
154MP0000750_abnormal_muscle_regeneration0.59794214
155MP0003638_abnormal_response/metabolism_0.59163596
156MP0002102_abnormal_ear_morphology0.58901510
157MP0003075_altered_response_to0.58869579
158MP0003656_abnormal_erythrocyte_physiolo0.58841682
159MP0001270_distended_abdomen0.58592176
160MP0010352_gastrointestinal_tract_polyps0.57280920
161MP0002136_abnormal_kidney_physiology0.56268674
162MP0005171_absent_coat_pigmentation0.56097386
163MP0000249_abnormal_blood_vessel0.55579865
164MP0005084_abnormal_gallbladder_morpholo0.55331078
165MP0002210_abnormal_sex_determination0.55165715
166MP0001919_abnormal_reproductive_system0.52636433
167MP0005584_abnormal_enzyme/coenzyme_acti0.52600859
168MP0003453_abnormal_keratinocyte_physiol0.52300472
169MP0000313_abnormal_cell_death0.50810476
170MP0000477_abnormal_intestine_morphology0.48022800
171MP0000371_diluted_coat_color0.47607927
172MP0001879_abnormal_lymphatic_vessel0.47526702
173MP0001191_abnormal_skin_condition0.47391354

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)8.60343439
2Abnormality of alanine metabolism (HP:0010916)8.60343439
3Hyperalaninemia (HP:0003348)8.60343439
4Constricted visual fields (HP:0001133)6.14484552
5Congenital sensorineural hearing impairment (HP:0008527)5.41346163
6Recurrent abscess formation (HP:0002722)5.23114176
7Eczematoid dermatitis (HP:0000976)4.91946934
8Elevated erythrocyte sedimentation rate (HP:0003565)4.82991692
9Recurrent bacterial skin infections (HP:0005406)4.78314389
10White forelock (HP:0002211)4.57250434
11Patchy hypopigmentation of hair (HP:0011365)4.49489579
12Myositis (HP:0100614)4.31130616
13Single umbilical artery (HP:0001195)4.30200582
14Abnormality of the fetal cardiovascular system (HP:0010948)4.30200582
15Abnormal umbilical cord blood vessels (HP:0011403)4.30200582
16Esophageal varix (HP:0002040)4.29219592
17Decreased electroretinogram (ERG) amplitude (HP:0000654)4.28928294
18Petechiae (HP:0000967)3.99274366
19Vacuolated lymphocytes (HP:0001922)3.96695720
20Abnormality of serum amino acid levels (HP:0003112)3.93605470
21Recurrent fungal infections (HP:0002841)3.86181048
22Thrombocytosis (HP:0001894)3.82623676
23Anorexia (HP:0002039)3.69423411
24Generalized aminoaciduria (HP:0002909)3.56035695
25Homocystinuria (HP:0002156)3.52073042
26Abnormality of homocysteine metabolism (HP:0010919)3.52073042
27Abnormality of macrophages (HP:0004311)3.50430466
28Recurrent skin infections (HP:0001581)3.47276289
29IgM deficiency (HP:0002850)3.44497977
30Mediastinal lymphadenopathy (HP:0100721)3.41952731
31Recurrent viral infections (HP:0004429)3.36813241
32Recurrent cutaneous fungal infections (HP:0011370)3.34691562
33Chronic mucocutaneous candidiasis (HP:0002728)3.34691562
34Chronic otitis media (HP:0000389)3.32670346
35Abnormality of cells of the erythroid lineage (HP:0012130)3.29524091
36Conjunctival telangiectasia (HP:0000524)3.28030349
37Abnormal number of erythroid precursors (HP:0012131)3.26637150
38Myocardial infarction (HP:0001658)3.26461768
39Stomatitis (HP:0010280)3.26236618
40Prolonged bleeding time (HP:0003010)3.21721273
41Optic neuritis (HP:0100653)3.20986424
42Retrobulbar optic neuritis (HP:0100654)3.20986424
43Orchitis (HP:0100796)3.18366200
44Autoimmune thrombocytopenia (HP:0001973)3.12148431
45Vasculitis (HP:0002633)3.08903418
46Recurrent bronchitis (HP:0002837)3.06272224
47Birth length less than 3rd percentile (HP:0003561)3.05986642
48Increased IgM level (HP:0003496)3.03657371
49IgG deficiency (HP:0004315)3.01562516
50Nausea (HP:0002018)2.97856668
51Recurrent gram-negative bacterial infections (HP:0005420)2.97829054
52Conjugated hyperbilirubinemia (HP:0002908)2.96648272
53Chronic obstructive pulmonary disease (HP:0006510)2.95692101
54Obstructive lung disease (HP:0006536)2.95692101
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95145899
56Panhypogammaglobulinemia (HP:0003139)2.90313828
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.88676046
58Abnormality of T cell number (HP:0011839)2.88037743
59Meningitis (HP:0001287)2.86969179
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.85341810
61Reticulocytopenia (HP:0001896)2.85047664
62Abnormality of the umbilical cord (HP:0010881)2.84731677
63Abnormality of T cells (HP:0002843)2.82728865
64Agammaglobulinemia (HP:0004432)2.81922567
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.79518857
66Poor speech (HP:0002465)2.75868077
67B lymphocytopenia (HP:0010976)2.71607051
68Abnormality of B cell number (HP:0010975)2.71607051
69Oligomenorrhea (HP:0000876)2.71120972
70T lymphocytopenia (HP:0005403)2.70402600
71Abnormality of T cell physiology (HP:0011840)2.69623908
72Cellulitis (HP:0100658)2.68951830
73Pulmonary embolism (HP:0002204)2.68675066
74Gastrointestinal stroma tumor (HP:0100723)2.68537871
75Pustule (HP:0200039)2.66939458
76Purpura (HP:0000979)2.66392252
77Action tremor (HP:0002345)2.66155600
78Epistaxis (HP:0000421)2.64766023
79Lymphopenia (HP:0001888)2.64148853
80Hyperglycinemia (HP:0002154)2.63821978
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.61578489
82Maternal diabetes (HP:0009800)2.59165525
83Aplastic anemia (HP:0001915)2.58752658
84Attenuation of retinal blood vessels (HP:0007843)2.55396579
85Heterochromia iridis (HP:0001100)2.55103406
86Hypergammaglobulinemia (HP:0010702)2.54957798
87Leukocytosis (HP:0001974)2.54863618
88Chronic diarrhea (HP:0002028)2.54145922
89Thyroiditis (HP:0100646)2.53118078
90Gingival bleeding (HP:0000225)2.52404441
91Gingivitis (HP:0000230)2.52019126
92Severe combined immunodeficiency (HP:0004430)2.48965414
93Autoimmune hemolytic anemia (HP:0001890)2.48280918
94Type I transferrin isoform profile (HP:0003642)2.42490683
95Interstitial pulmonary disease (HP:0006530)2.40391506
96Pigmentary retinal degeneration (HP:0001146)2.38748053
97Hemoptysis (HP:0002105)2.38650249
98Recurrent pneumonia (HP:0006532)2.35603258
99Granulocytopenia (HP:0001913)2.35476913
100Abnormality of eosinophils (HP:0001879)2.34963718
101Eosinophilia (HP:0001880)2.34822152
102Acute necrotizing encephalopathy (HP:0006965)2.34393010
103Basal ganglia calcification (HP:0002135)2.32734183
104Reduced antithrombin III activity (HP:0001976)2.32221624
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.31970571
106Reduced subcutaneous adipose tissue (HP:0003758)2.30095108
107Chorioretinal atrophy (HP:0000533)2.29687280
108Pallor (HP:0000980)2.28751818
109Inflammation of the large intestine (HP:0002037)2.28304053
110Spontaneous hematomas (HP:0007420)2.26688071
111Lactic acidosis (HP:0003128)2.26162075
112Methylmalonic acidemia (HP:0002912)2.25820621
113Mitochondrial inheritance (HP:0001427)2.25636187
114Acute encephalopathy (HP:0006846)2.25140917
115Arterial thrombosis (HP:0004420)2.24975325
116Periodontitis (HP:0000704)2.24932638
117Hypoplasia of the thymus (HP:0000778)2.23762996
118Increased serum lactate (HP:0002151)2.23657506
119Hypoalphalipoproteinemia (HP:0003233)2.22890275
120Fatigue (HP:0012378)2.21188561
121Pulmonary infiltrates (HP:0002113)2.20776182
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20210379
123Neutropenia (HP:0001875)2.20042382
124Thrombophlebitis (HP:0004418)2.19143368
125Hypoproteinemia (HP:0003075)2.19094870
126Osteomyelitis (HP:0002754)2.18256004
127Type 2 muscle fiber atrophy (HP:0003554)2.17875170
128Increased IgE level (HP:0003212)2.17069886
129Gastrointestinal inflammation (HP:0004386)2.16675745
130Combined immunodeficiency (HP:0005387)2.16410458
131Encephalitis (HP:0002383)2.16358782
132Abnormal mitochondria in muscle tissue (HP:0008316)2.15817169
133Increased serum pyruvate (HP:0003542)2.15249005
134Recurrent lower respiratory tract infections (HP:0002783)2.14536296
135Lymphoma (HP:0002665)2.14463693
136IgA deficiency (HP:0002720)2.14261902
137Hyperphosphaturia (HP:0003109)2.14254058
138Abnormality of the prostate (HP:0008775)2.11586911
139Metabolic acidosis (HP:0001942)2.10579980
140Keratoconjunctivitis sicca (HP:0001097)2.10415188
141Myopathic facies (HP:0002058)2.09054113
142Exertional dyspnea (HP:0002875)2.08782146
143Nasal polyposis (HP:0100582)2.05659314
144Pendular nystagmus (HP:0012043)2.05422309
145Visceral angiomatosis (HP:0100761)2.01175104
146Abnormalities of placenta or umbilical cord (HP:0001194)2.01076238
147Keratoconjunctivitis (HP:0001096)2.00615739
148Abnormality of the nasal mucosa (HP:0000433)2.00576310
149Urticaria (HP:0001025)2.00353780
150Cortical visual impairment (HP:0100704)1.99254693
151Hepatocellular necrosis (HP:0001404)1.98435069
152Stenosis of the external auditory canal (HP:0000402)1.98422516
153Chronic hepatic failure (HP:0100626)1.98414647
154Abnormality of the heme biosynthetic pathway (HP:0010472)1.98308093
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97439883
156Abnormal protein N-linked glycosylation (HP:0012347)1.97439883
157Abnormal protein glycosylation (HP:0012346)1.97439883
158Abnormal glycosylation (HP:0012345)1.97439883
159Cerebral edema (HP:0002181)1.96806527
160Abnormal respiratory epithelium morphology (HP:0012253)1.95834114
161Abnormal respiratory motile cilium morphology (HP:0005938)1.95834114
162Increased cerebral lipofuscin (HP:0011813)1.93474470
163Abnormal platelet function (HP:0011869)1.92935672
164Increased CSF lactate (HP:0002490)1.92145573
165Proximal tubulopathy (HP:0000114)1.90956109
166Toxemia of pregnancy (HP:0100603)1.90049349
167Hypoplastic left heart (HP:0004383)1.89886786
168Abolished electroretinogram (ERG) (HP:0000550)1.88173592
169Cavernous hemangioma (HP:0001048)1.87653904
170Anencephaly (HP:0002323)1.86381853
171Hepatic necrosis (HP:0002605)1.86275339
172Progressive macrocephaly (HP:0004481)1.85909290
173Supernumerary spleens (HP:0009799)1.85706435
174Chronic sinusitis (HP:0011109)1.85638524
175Cone-rod dystrophy (HP:0000548)1.85311836
176Pancreatitis (HP:0001733)1.84909146
177Ileus (HP:0002595)1.83822905
178Abnormality of urine glucose concentration (HP:0011016)1.83363057
179Glycosuria (HP:0003076)1.83363057
180Muscle fiber atrophy (HP:0100295)1.80650271
181Long clavicles (HP:0000890)1.80088905
182Symptomatic seizures (HP:0011145)1.80038404
183Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79834142
184Decreased subcutaneous fat (HP:0001002)1.75591083
185True hermaphroditism (HP:0010459)1.75259281
186Epidermoid cyst (HP:0200040)1.73610519
187Methylmalonic aciduria (HP:0012120)1.72900165
188Hemangiomatosis (HP:0007461)1.72839362
189Molar tooth sign on MRI (HP:0002419)1.72547956
190Abnormality of midbrain morphology (HP:0002418)1.72547956
191Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72520652
192Abnormality of glycolysis (HP:0004366)1.71048477
193Lethargy (HP:0001254)1.70808351
194Dicarboxylic aciduria (HP:0003215)1.69665688
195Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69665688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.58780875
2TXK3.74029069
3MAP4K13.54162109
4MAP3K143.32738994
5FGR2.92992189
6NME22.72233334
7TBK12.70630737
8CDK92.70603353
9JAK32.63515193
10EPHB22.62113618
11BLK2.61520450
12IRAK42.61195831
13VRK22.56484323
14KIT2.48067548
15IKBKE2.42126145
16PIM22.40252913
17BCKDK2.36923704
18TYK22.35131786
19TEC2.33812825
20NTRK22.22407193
21IKBKB2.18874266
22IRAK32.13652625
23MAP4K22.07831264
24BTK2.03627064
25ZAP702.01881068
26TGFBR21.83176804
27MAP3K121.82100468
28RIPK41.80676940
29SGK2231.72241925
30SGK4941.72241925
31SYK1.60606179
32MST41.54222957
33PBK1.52332834
34NLK1.36206633
35WNK31.31885240
36LCK1.31537390
37MAP3K131.30280347
38SGK21.29980190
39LYN1.28924622
40ITK1.26746130
41ADRBK11.26620860
42DYRK21.25625168
43JAK11.24937726
44PIM11.24844803
45SIK31.24305982
46TGFBR11.23554264
47TRIM281.23371686
48CHUK1.23342512
49MUSK1.18323097
50TESK21.17052083
51CSF1R1.16442345
52GRK11.10994289
53BMPR21.10513764
54NEK91.10160556
55RPS6KA41.04545970
56MAP2K31.04501977
57OBSCN1.04305142
58CSNK1A11.04000840
59HCK1.02710057
60TRPM71.01640458
61BUB11.01527729
62NEK11.01516126
63VRK11.00444738
64MATK0.97581566
65MAP3K110.96217588
66PAK40.94982290
67ERBB30.94513708
68KDR0.94482067
69MYLK0.94381786
70INSRR0.91994944
71TLK10.90540859
72CLK10.89222831
73YES10.88496922
74FGFR30.86716930
75LRRK20.86578146
76FGFR40.85127207
77STK160.84645793
78LMTK20.83853345
79CSK0.83747883
80AURKA0.82897264
81CSNK1G30.80921700
82EPHA30.80870814
83STK100.78038046
84TAOK30.76861241
85FLT30.76178346
86NTRK30.75690996
87PINK10.72903525
88GRK70.72713522
89ADRBK20.68340899
90PRKCE0.67866330
91NUAK10.67458028
92TNIK0.67135894
93STK40.66678646
94MAP2K60.65543998
95SGK30.65345420
96IRAK10.65181021
97JAK20.64483260
98EIF2AK20.64463167
99PHKG10.63567155
100PHKG20.63567155
101PRKG20.62840625
102TAF10.62491814
103SRPK10.62450998
104CCNB10.61691602
105CSNK1G20.61473814
106PRKCI0.61008958
107LIMK10.60410742
108UHMK10.59190944
109RPS6KA50.58936178
110CSNK1G10.58435907
111CAMK2D0.58265946
112MAP2K70.57502618
113RPS6KB20.56835970
114PIK3CG0.56491309
115MARK30.56036573
116ACVR1B0.55749349
117NEK60.55679319
118TIE10.54375504
119ERN10.54360342
120RPS6KA60.54071939
121EIF2AK10.53973755
122FES0.52688970
123MAPKAPK20.52267844
124PRKCQ0.51152804
125EIF2AK30.51052683
126PIK3CA0.50421228
127PDK20.49614015
128MAP2K10.49587420
129INSR0.49535434
130TNK20.49260756
131ILK0.48311107
132EPHB10.47384698
133CSNK1A1L0.47269979
134PLK40.46869043
135MAP3K40.46568039
136CSNK2A10.46555110
137BMPR1B0.45628135
138PRKCD0.45416141
139GRK60.43752904
140STK240.43633866
141FRK0.43198313
142CAMK2G0.43131041
143PLK30.42857897
144BCR0.42857571
145MAPKAPK50.42747409
146ZAK0.42643220
147DYRK30.41857093
148PRKCA0.39493673
149DAPK30.38883167
150EGFR0.38267030
151ABL10.38083874
152CAMK2A0.36960490
153MAPK40.36651531
154RPS6KL10.36364033
155RPS6KC10.36364033
156MKNK10.35983369
157PRKACA0.35636304
158RPS6KB10.34757961
159CAMK2B0.34353070
160ARAF0.32908389
161ABL20.32388121
162DYRK1B0.30180818
163ATR0.29635823

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.75988516
2Sulfur metabolism_Homo sapiens_hsa009203.49516639
3Collecting duct acid secretion_Homo sapiens_hsa049663.23563078
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.94365529
5Primary immunodeficiency_Homo sapiens_hsa053402.94126009
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.86250203
7Ribosome_Homo sapiens_hsa030102.85554130
8Allograft rejection_Homo sapiens_hsa053302.72547018
9Arginine biosynthesis_Homo sapiens_hsa002202.66168624
10Leishmaniasis_Homo sapiens_hsa051402.61058640
11Graft-versus-host disease_Homo sapiens_hsa053322.52794907
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.52297062
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.45677441
14Sulfur relay system_Homo sapiens_hsa041222.25407108
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22979214
16Measles_Homo sapiens_hsa051622.19911050
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.17475799
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14880592
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.06398130
20Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06378836
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05273725
22Hematopoietic cell lineage_Homo sapiens_hsa046402.04922615
23Asthma_Homo sapiens_hsa053101.98831169
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.98334948
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96543571
26Osteoclast differentiation_Homo sapiens_hsa043801.84590049
27Antigen processing and presentation_Homo sapiens_hsa046121.75966008
28Herpes simplex infection_Homo sapiens_hsa051681.75577098
29Selenocompound metabolism_Homo sapiens_hsa004501.74756530
30Legionellosis_Homo sapiens_hsa051341.71993655
31B cell receptor signaling pathway_Homo sapiens_hsa046621.67373135
32Autoimmune thyroid disease_Homo sapiens_hsa053201.61170814
33Pertussis_Homo sapiens_hsa051331.59455084
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57571205
35Other glycan degradation_Homo sapiens_hsa005111.56174271
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55836464
37Proteasome_Homo sapiens_hsa030501.55038723
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52088487
39Malaria_Homo sapiens_hsa051441.50519006
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.49045795
41Influenza A_Homo sapiens_hsa051641.45551744
42Rheumatoid arthritis_Homo sapiens_hsa053231.43465034
43TNF signaling pathway_Homo sapiens_hsa046681.36607132
44Tuberculosis_Homo sapiens_hsa051521.35888864
45Propanoate metabolism_Homo sapiens_hsa006401.34515052
46Regulation of autophagy_Homo sapiens_hsa041401.34443000
47Toxoplasmosis_Homo sapiens_hsa051451.33028615
48Huntingtons disease_Homo sapiens_hsa050161.32887153
49Alzheimers disease_Homo sapiens_hsa050101.32128913
50Vibrio cholerae infection_Homo sapiens_hsa051101.31092058
51Shigellosis_Homo sapiens_hsa051311.30791790
52T cell receptor signaling pathway_Homo sapiens_hsa046601.30380459
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29418079
54Peroxisome_Homo sapiens_hsa041461.28522194
55Vitamin digestion and absorption_Homo sapiens_hsa049771.27163820
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26668705
57DNA replication_Homo sapiens_hsa030301.26508600
58Biosynthesis of amino acids_Homo sapiens_hsa012301.26383629
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26229643
60Folate biosynthesis_Homo sapiens_hsa007901.24695258
61Protein export_Homo sapiens_hsa030601.24205481
62Salmonella infection_Homo sapiens_hsa051321.22212822
63GABAergic synapse_Homo sapiens_hsa047271.21904568
64Retinol metabolism_Homo sapiens_hsa008301.18137170
65Type I diabetes mellitus_Homo sapiens_hsa049401.17652670
66Apoptosis_Homo sapiens_hsa042101.16469697
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15445266
68Staphylococcus aureus infection_Homo sapiens_hsa051501.14485823
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13395386
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12797177
71Morphine addiction_Homo sapiens_hsa050321.11777698
72Viral myocarditis_Homo sapiens_hsa054161.10891318
73Chemokine signaling pathway_Homo sapiens_hsa040621.09664941
74Nitrogen metabolism_Homo sapiens_hsa009101.06931982
75Hepatitis B_Homo sapiens_hsa051611.06768075
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03132755
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01407042
78Base excision repair_Homo sapiens_hsa034101.01096334
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97600224
80Platelet activation_Homo sapiens_hsa046110.94749822
81Mismatch repair_Homo sapiens_hsa034300.94470632
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94277820
83Arginine and proline metabolism_Homo sapiens_hsa003300.94121254
84African trypanosomiasis_Homo sapiens_hsa051430.92714908
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.92249677
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91965890
87Lysosome_Homo sapiens_hsa041420.91390774
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91147298
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89407009
90Epstein-Barr virus infection_Homo sapiens_hsa051690.87717544
91Acute myeloid leukemia_Homo sapiens_hsa052210.86205530
92Homologous recombination_Homo sapiens_hsa034400.85921996
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85831585
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.85281007
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83819947
96Metabolic pathways_Homo sapiens_hsa011000.80972142
97Butanoate metabolism_Homo sapiens_hsa006500.80256814
98Glutathione metabolism_Homo sapiens_hsa004800.79800996
99Chemical carcinogenesis_Homo sapiens_hsa052040.79698111
100RNA polymerase_Homo sapiens_hsa030200.78678521
101Hepatitis C_Homo sapiens_hsa051600.78309209
102Nicotine addiction_Homo sapiens_hsa050330.77456843
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76214024
104Phagosome_Homo sapiens_hsa041450.75977899
105Non-homologous end-joining_Homo sapiens_hsa034500.74543477
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.74497932
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73894746
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71062339
109Pyrimidine metabolism_Homo sapiens_hsa002400.70160548
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69812397
111Tryptophan metabolism_Homo sapiens_hsa003800.69594270
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68126310
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67917340
114Carbon metabolism_Homo sapiens_hsa012000.67861092
115Fatty acid elongation_Homo sapiens_hsa000620.67090391
116Nucleotide excision repair_Homo sapiens_hsa034200.66992765
117Synaptic vesicle cycle_Homo sapiens_hsa047210.65975217
118Serotonergic synapse_Homo sapiens_hsa047260.64922026
119Spliceosome_Homo sapiens_hsa030400.64644149
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63290255
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62186717
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60869681
123p53 signaling pathway_Homo sapiens_hsa041150.57934882
124Caffeine metabolism_Homo sapiens_hsa002320.57750669
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.54691428
126Purine metabolism_Homo sapiens_hsa002300.54198480
127Ether lipid metabolism_Homo sapiens_hsa005650.54009980
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53183600
129RNA degradation_Homo sapiens_hsa030180.51910208
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50919941
131Sphingolipid metabolism_Homo sapiens_hsa006000.50044036
132Chronic myeloid leukemia_Homo sapiens_hsa052200.49286453
133Cardiac muscle contraction_Homo sapiens_hsa042600.48143030
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47591557
135Prolactin signaling pathway_Homo sapiens_hsa049170.47048961
136HTLV-I infection_Homo sapiens_hsa051660.46470004
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45995820
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45444790
139Pancreatic cancer_Homo sapiens_hsa052120.44979529
140Viral carcinogenesis_Homo sapiens_hsa052030.44494867
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44002692
142Pyruvate metabolism_Homo sapiens_hsa006200.43674313
143Arachidonic acid metabolism_Homo sapiens_hsa005900.42871593
144Fat digestion and absorption_Homo sapiens_hsa049750.42634198
145Linoleic acid metabolism_Homo sapiens_hsa005910.39636882
146N-Glycan biosynthesis_Homo sapiens_hsa005100.39622258
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39398703
148Small cell lung cancer_Homo sapiens_hsa052220.39315718
149RNA transport_Homo sapiens_hsa030130.37837852
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37066688
151Oxidative phosphorylation_Homo sapiens_hsa001900.36868935
152Dopaminergic synapse_Homo sapiens_hsa047280.35206642
153PPAR signaling pathway_Homo sapiens_hsa033200.34487069
154Parkinsons disease_Homo sapiens_hsa050120.33425601
155Basal transcription factors_Homo sapiens_hsa030220.32157331
156Fanconi anemia pathway_Homo sapiens_hsa034600.31329733
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.30750535
158Galactose metabolism_Homo sapiens_hsa000520.25363671
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24332658
160Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22694924
161Systemic lupus erythematosus_Homo sapiens_hsa053220.22680539

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »