PLIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)9.33749348
2white fat cell differentiation (GO:0050872)8.04700999
3brown fat cell differentiation (GO:0050873)7.90528296
4biotin metabolic process (GO:0006768)7.30640122
5valine metabolic process (GO:0006573)7.11458166
6* triglyceride catabolic process (GO:0019433)6.83373136
7fatty acid transmembrane transport (GO:1902001)6.37368901
8lipid particle organization (GO:0034389)6.24813251
9triglyceride biosynthetic process (GO:0019432)6.17023995
10transcytosis (GO:0045056)6.12745001
11* acylglycerol catabolic process (GO:0046464)6.04995539
12* neutral lipid catabolic process (GO:0046461)6.04995539
13positive regulation of fatty acid oxidation (GO:0046321)6.04838625
14positive regulation of fatty acid beta-oxidation (GO:0032000)6.03595401
15neutral lipid biosynthetic process (GO:0046460)5.90671311
16acylglycerol biosynthetic process (GO:0046463)5.90671311
17carnitine shuttle (GO:0006853)5.89386581
18regulation of cholesterol storage (GO:0010885)5.86734221
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.75837725
20lipid storage (GO:0019915)5.54727517
21fatty acid beta-oxidation (GO:0006635)5.42557616
22response to dietary excess (GO:0002021)5.36427233
23negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)5.15867961
24branched-chain amino acid metabolic process (GO:0009081)4.92372378
25polyol transport (GO:0015791)4.84354501
26fatty-acyl-CoA biosynthetic process (GO:0046949)4.83756417
27branched-chain amino acid catabolic process (GO:0009083)4.82389964
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.80283018
29regulation of fatty acid oxidation (GO:0046320)4.78114709
30fatty acid oxidation (GO:0019395)4.75770468
31acyl-CoA biosynthetic process (GO:0071616)4.75713117
32thioester biosynthetic process (GO:0035384)4.75713117
33fatty-acyl-CoA metabolic process (GO:0035337)4.75146991
34coenzyme A biosynthetic process (GO:0015937)4.73964556
35carnitine transmembrane transport (GO:1902603)4.70137124
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.68086759
37lipid oxidation (GO:0034440)4.67064379
38ethanol oxidation (GO:0006069)4.64101091
39fatty acid catabolic process (GO:0009062)4.59897814
40* glycerolipid catabolic process (GO:0046503)4.51896633
41protein heterotrimerization (GO:0070208)4.49246101
42regulation of fatty acid beta-oxidation (GO:0031998)4.42670583
43negative regulation of protein autophosphorylation (GO:0031953)4.32474603
44fatty acid homeostasis (GO:0055089)4.31828072
45carnitine transport (GO:0015879)4.28468608
46amino-acid betaine transport (GO:0015838)4.28468608
47* triglyceride metabolic process (GO:0006641)4.27906259
48ovulation from ovarian follicle (GO:0001542)4.27041862
49positive regulation of cellular response to insulin stimulus (GO:1900078)4.26529653
50negative regulation of granulocyte differentiation (GO:0030853)4.22841706
51positive regulation of fatty acid metabolic process (GO:0045923)4.16877665
52acetyl-CoA metabolic process (GO:0006084)4.14707781
53regulation of cAMP-dependent protein kinase activity (GO:2000479)4.13766497
54negative regulation of lipid storage (GO:0010888)4.12686247
55regulation of macrophage derived foam cell differentiation (GO:0010743)4.11820122
56negative regulation of phagocytosis (GO:0050765)4.08126117
57cellular response to lithium ion (GO:0071285)4.07636219
58positive regulation of lipid catabolic process (GO:0050996)4.06210170
59negative regulation of smooth muscle cell migration (GO:0014912)4.05604968
60negative regulation of amino acid transport (GO:0051956)4.05499102
61positive regulation of lipid storage (GO:0010884)4.05093286
62plasma lipoprotein particle clearance (GO:0034381)4.04523393
63* acylglycerol metabolic process (GO:0006639)4.03602739
64regulation of gonadotropin secretion (GO:0032276)4.02235639
65response to phenylpropanoid (GO:0080184)4.00775862
66* neutral lipid metabolic process (GO:0006638)3.97966185
67glycerol metabolic process (GO:0006071)3.96878491
68NADH metabolic process (GO:0006734)3.96120299
69negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.93757997
70positive regulation of glomerulus development (GO:0090193)3.90864923
71cellular response to epinephrine stimulus (GO:0071872)3.89924999
72CDP-diacylglycerol metabolic process (GO:0046341)3.87825598
73positive regulation of glucose import (GO:0046326)3.85791245
74intracellular lipid transport (GO:0032365)3.82672584
75positive regulation of triglyceride lipase activity (GO:0061365)3.80389909
76positive regulation of lipoprotein lipase activity (GO:0051006)3.80389909
77tricarboxylic acid metabolic process (GO:0072350)3.79076658
78positive regulation of insulin receptor signaling pathway (GO:0046628)3.77053606
79alpha-linolenic acid metabolic process (GO:0036109)3.74865751
80positive regulation of glycolytic process (GO:0045821)3.74135321
81regulation of glycogen (starch) synthase activity (GO:2000465)3.72895406
82pentose-phosphate shunt (GO:0006098)3.71485260
83response to epinephrine (GO:0071871)3.70048042
84regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.70000536
85retina vasculature morphogenesis in camera-type eye (GO:0061299)3.65324113
86positive regulation of cholesterol efflux (GO:0010875)3.65087464
87NADPH regeneration (GO:0006740)3.64832351
88diacylglycerol metabolic process (GO:0046339)3.63568118
89negative regulation of macrophage differentiation (GO:0045650)3.61794648
90primary alcohol metabolic process (GO:0034308)3.60995495
91CDP-diacylglycerol biosynthetic process (GO:0016024)3.59991738
92cGMP-mediated signaling (GO:0019934)3.58387183
93regulation of lipid storage (GO:0010883)3.57157405
94coenzyme A metabolic process (GO:0015936)3.55734561
95glomerular filtration (GO:0003094)3.55346453
96positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.54470231
97regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.54089144
98ethanol metabolic process (GO:0006067)3.52560659
99positive regulation of cholesterol transport (GO:0032376)3.51993202
100positive regulation of sterol transport (GO:0032373)3.51993202
101regulation of receptor binding (GO:1900120)3.50686751
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49829054
103regulation of lipoprotein metabolic process (GO:0050746)3.47399175
104negative regulation of gluconeogenesis (GO:0045721)3.47230243
105growth hormone receptor signaling pathway (GO:0060396)3.47147032
106negative regulation of metanephros development (GO:0072217)3.46989046
107oxaloacetate metabolic process (GO:0006107)3.46805710
108alditol metabolic process (GO:0019400)3.46557750
109tricarboxylic acid cycle (GO:0006099)3.43173480
110protein localization to cell surface (GO:0034394)3.42774938
111regulation of triglyceride catabolic process (GO:0010896)3.42008081
112monocarboxylic acid catabolic process (GO:0072329)3.41049203
113negative regulation of DNA biosynthetic process (GO:2000279)3.40562392
114fat cell differentiation (GO:0045444)3.40087546
115L-serine transport (GO:0015825)3.37881671
116regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.37133856
117long-chain fatty acid transport (GO:0015909)3.37060254
118barbed-end actin filament capping (GO:0051016)3.35305589
119regulation of triglyceride biosynthetic process (GO:0010866)3.34492164
120triglyceride homeostasis (GO:0070328)3.33450255
121acylglycerol homeostasis (GO:0055090)3.33450255
122phosphatidic acid biosynthetic process (GO:0006654)3.33092679
123phosphatidic acid metabolic process (GO:0046473)3.33092679
124retinol metabolic process (GO:0042572)3.32913783
125succinate metabolic process (GO:0006105)3.30042224
126cellular response to leptin stimulus (GO:0044320)3.26436280
127negative regulation of smooth muscle cell proliferation (GO:0048662)3.25804857
128positive regulation of metanephros development (GO:0072216)3.22245722
129negative regulation of lipid catabolic process (GO:0050995)3.19975771
130tyrosine phosphorylation of STAT protein (GO:0007260)3.17091191
131renal filtration (GO:0097205)3.15161007
132endocrine hormone secretion (GO:0060986)3.13866907
133positive regulation of glucose transport (GO:0010828)3.13476721
134response to vitamin E (GO:0033197)3.12074060
135cellular response to vitamin (GO:0071295)3.11320717
136regulation of glomerulus development (GO:0090192)3.08285191
137response to hydroperoxide (GO:0033194)3.07890370
138angiogenesis involved in wound healing (GO:0060055)3.06488992
139low-density lipoprotein particle clearance (GO:0034383)10.0716960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse7.04314698
2CLOCK_20551151_ChIP-Seq_293T_Human4.51529991
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.77424294
4PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.76294065
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.42001999
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.34077472
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.32798731
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.31469200
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28995199
10PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.27965709
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse16.1566593
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89606579
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88223879
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85104013
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80437381
16GATA1_22025678_ChIP-Seq_K562_Human1.79400565
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79110068
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77371422
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76520377
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64905977
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64405477
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63320563
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54939192
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38364840
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.37698501
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37661814
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30477564
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26081897
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.23457697
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23212846
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21523677
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19079129
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16347355
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.16194974
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.16194974
36VDR_24787735_ChIP-Seq_THP-1_Human1.15212113
37ZNF263_19887448_ChIP-Seq_K562_Human1.14694293
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13815218
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13625377
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.10999909
41RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10893396
42* SA1_22415368_ChIP-Seq_MEFs_Mouse1.09489043
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09282599
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09156932
45CJUN_26792858_Chip-Seq_BT549_Human1.08511006
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07207614
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.06802665
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.06178802
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06142762
50SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05105627
51KDM2B_26808549_Chip-Seq_K562_Human1.04626071
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02954393
53EP300_21415370_ChIP-Seq_HL-1_Mouse0.99891582
54CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99299129
55LXR_22292898_ChIP-Seq_THP-1_Human0.99150187
56ERG_21242973_ChIP-ChIP_JURKAT_Human0.98869148
57SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97699352
58* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93913778
59JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93321344
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92979875
61PIAS1_25552417_ChIP-Seq_VCAP_Human0.92763905
62SMAD_19615063_ChIP-ChIP_OVARY_Human0.91779958
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91589910
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90633253
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90081546
66RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89254907
67EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89254907
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88079454
69ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87766621
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86876194
71TP53_20018659_ChIP-ChIP_R1E_Mouse0.86368330
72IRF8_22096565_ChIP-ChIP_GC-B_Human0.85293406
73CTCF_27219007_Chip-Seq_Bcells_Human0.84484010
74SALL1_21062744_ChIP-ChIP_HESCs_Human0.84054421
75EZH2_27304074_Chip-Seq_ESCs_Mouse0.83500253
76TET1_21490601_ChIP-Seq_MESCs_Mouse0.82787974
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.82138419
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81121695
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80915063
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79643404
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79354837
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79354837
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78483069
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78047834
85BCAT_22108803_ChIP-Seq_LS180_Human0.77912920
86CBP_21632823_ChIP-Seq_H3396_Human0.77757809
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76691065
88SMC4_20622854_ChIP-Seq_HELA_Human0.76356996
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.75569925
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.75569925
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.75569925
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75546171
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73755005
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73155702
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71458985
96KDM2B_26808549_Chip-Seq_DND41_Human0.70846975
97GATA1_19941826_ChIP-Seq_K562_Human0.70775335
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70567986
99RACK7_27058665_Chip-Seq_MCF-7_Human0.70500373
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70278518
101RNF2_27304074_Chip-Seq_ESCs_Mouse0.69503933
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69446622
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69212894
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.68777387
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68094280
106FOXA2_19822575_ChIP-Seq_HepG2_Human0.67800694
107SOX11_22085726_ChIP-Seq_ESNs_Mouse0.67695555
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67641730
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67549126
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67120679
111SOX2_20726797_ChIP-Seq_SW620_Human0.66141657
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.64727182
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64656276
114KLF4_19829295_ChIP-Seq_ESCs_Human0.62816339
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.62250799
116RUNX_20019798_ChIP-Seq_JUKART_Human0.61922786
117* RXR_22108803_ChIP-Seq_LS180_Human0.61475719
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.58897081
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58786244
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57311882
121GATA2_19941826_ChIP-Seq_K562_Human0.56984064
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.55014673
123GATA3_21878914_ChIP-Seq_MCF-7_Human0.54959276
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.54951731
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.54351852
126GBX2_23144817_ChIP-Seq_PC3_Human0.53242060
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53057530
128CEBPB_22108803_ChIP-Seq_LS180_Human0.52873532
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.52416133
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.52250692
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.52174882
132* GATA3_24758297_ChIP-Seq_MCF-7_Human0.51760718
133AHR_22903824_ChIP-Seq_MCF-7_Human0.51647280
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.50636347
135CBP_20019798_ChIP-Seq_JUKART_Human0.50440641
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.50440641
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.49942634
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.49889262
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.49778458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose9.05104182
2MP0004130_abnormal_muscle_cell5.17946798
3* MP0005666_abnormal_adipose_tissue5.15739488
4MP0004185_abnormal_adipocyte_glucose5.12177858
5MP0008438_abnormal_cutaneous_collagen4.45929367
6* MP0005375_adipose_tissue_phenotype3.93977470
7MP0000013_abnormal_adipose_tissue3.55240278
8MP0002876_abnormal_thyroid_physiology3.28924210
9MP0002837_dystrophic_cardiac_calcinosis3.24995643
10MP0000003_abnormal_adipose_tissue3.11277533
11* MP0002971_abnormal_brown_adipose3.10590921
12MP0005275_abnormal_skin_tensile2.89545862
13MP0010329_abnormal_lipoprotein_level2.77710895
14* MP0009115_abnormal_fat_cell2.59333652
15* MP0005334_abnormal_fat_pad2.50549965
16MP0005503_abnormal_tendon_morphology2.41552203
17MP0003191_abnormal_cellular_cholesterol2.40582574
18MP0001661_extended_life_span2.26855032
19* MP0002970_abnormal_white_adipose2.19672977
20MP0003011_delayed_dark_adaptation2.09034402
21* MP0002118_abnormal_lipid_homeostasis1.95188143
22MP0003868_abnormal_feces_composition1.90901329
23* MP0005535_abnormal_body_temperature1.84710717
24MP0004272_abnormal_basement_membrane1.79408964
25MP0003724_increased_susceptibility_to1.79192121
26MP0005167_abnormal_blood-brain_barrier1.71442051
27MP0003705_abnormal_hypodermis_morpholog1.61114509
28MP0003690_abnormal_glial_cell1.58104664
29MP0003186_abnormal_redox_activity1.55083242
30* MP0005452_abnormal_adipose_tissue1.44427058
31MP0003828_pulmonary_edema1.38563402
32MP0003279_aneurysm1.38283735
33* MP0003959_abnormal_lean_body1.36532285
34* MP0005448_abnormal_energy_balance1.34829201
35MP0000609_abnormal_liver_physiology1.26336908
36* MP0002078_abnormal_glucose_homeostasis1.25788713
37MP0006138_congestive_heart_failure1.23863090
38MP0001881_abnormal_mammary_gland1.21280096
39MP0001501_abnormal_sleep_pattern1.18850126
40MP0002933_joint_inflammation1.14884377
41MP0010368_abnormal_lymphatic_system1.13937751
42MP0003646_muscle_fatigue1.13863422
43MP0002060_abnormal_skin_morphology1.13727029
44MP0002909_abnormal_adrenal_gland1.13502739
45MP0002166_altered_tumor_susceptibility1.12635912
46MP0002638_abnormal_pupillary_reflex1.12202356
47MP0009780_abnormal_chondrocyte_physiolo1.11649947
48MP0001727_abnormal_embryo_implantation1.11046347
49MP0005365_abnormal_bile_salt1.07306810
50MP0008775_abnormal_heart_ventricle1.04737387
51MP0003045_fibrosis1.04583987
52MP0000343_altered_response_to1.02448728
53MP0002796_impaired_skin_barrier0.99463894
54MP0000767_abnormal_smooth_muscle0.98853977
55MP0005645_abnormal_hypothalamus_physiol0.98118604
56MP0006036_abnormal_mitochondrial_physio0.98031389
57MP0005379_endocrine/exocrine_gland_phen0.96368838
58MP0002254_reproductive_system_inflammat0.96002959
59MP0000750_abnormal_muscle_regeneration0.95116238
60MP0002006_tumorigenesis0.89149997
61MP0000751_myopathy0.88878695
62MP0001544_abnormal_cardiovascular_syste0.88521802
63MP0005385_cardiovascular_system_phenoty0.88521802
64MP0005620_abnormal_muscle_contractility0.86319549
65MP0005584_abnormal_enzyme/coenzyme_acti0.85320347
66MP0005164_abnormal_response_to0.84637618
67MP0003950_abnormal_plasma_membrane0.81095982
68MP0001764_abnormal_homeostasis0.80741820
69MP0004147_increased_porphyrin_level0.80271724
70MP0002332_abnormal_exercise_endurance0.80201378
71MP0003566_abnormal_cell_adhesion0.80160417
72MP0004084_abnormal_cardiac_muscle0.79598362
73MP0004087_abnormal_muscle_fiber0.76745457
74MP0001756_abnormal_urination0.76591415
75MP0008961_abnormal_basal_metabolism0.76350413
76* MP0003948_abnormal_gas_homeostasis0.75075259
77* MP0003953_abnormal_hormone_level0.74750179
78MP0006276_abnormal_autonomic_nervous0.73788681
79MP0005319_abnormal_enzyme/_coenzyme0.70901338
80MP0002168_other_aberrant_phenotype0.70529715
81MP0003221_abnormal_cardiomyocyte_apopto0.69722189
82MP0001879_abnormal_lymphatic_vessel0.67706925
83MP0001177_atelectasis0.67681647
84* MP0000759_abnormal_skeletal_muscle0.66550112
85MP0000749_muscle_degeneration0.65708305
86MP0005508_abnormal_skeleton_morphology0.64524286
87MP0003075_altered_response_to0.62878019
88MP0009643_abnormal_urine_homeostasis0.59130619
89MP0002108_abnormal_muscle_morphology0.58754021
90MP0002295_abnormal_pulmonary_circulatio0.57634813
91MP0004036_abnormal_muscle_relaxation0.57599666
92MP0000230_abnormal_systemic_arterial0.57302849
93MP0010630_abnormal_cardiac_muscle0.57211269
94MP0005332_abnormal_amino_acid0.57168453
95MP0004215_abnormal_myocardial_fiber0.56299190
96MP0002972_abnormal_cardiac_muscle0.56102301
97MP0005330_cardiomyopathy0.55916533
98MP0000427_abnormal_hair_cycle0.55360276
99MP0004858_abnormal_nervous_system0.55152512
100MP0003091_abnormal_cell_migration0.52994005
101MP0002133_abnormal_respiratory_system0.52665395
102MP0005388_respiratory_system_phenotype0.52665395
103MP0005266_abnormal_metabolism0.52181122
104MP0005165_increased_susceptibility_to0.52048095
105MP0009763_increased_sensitivity_to0.51251027
106MP0002998_abnormal_bone_remodeling0.51126923
107MP0005369_muscle_phenotype0.51005236
108MP0001944_abnormal_pancreas_morphology0.50939219
109MP0001533_abnormal_skeleton_physiology0.50590675
110MP0005595_abnormal_vascular_smooth0.50365453
111MP0009672_abnormal_birth_weight0.50341054
112MP0001614_abnormal_blood_vessel0.49223047
113MP0000249_abnormal_blood_vessel0.49202692
114MP0002128_abnormal_blood_circulation0.49087967
115MP0005647_abnormal_sex_gland0.48521870
116MP0005397_hematopoietic_system_phenotyp0.46261415
117MP0002139_abnormal_hepatobiliary_system0.46217044
118MP0001958_emphysema0.45017011
119MP0001853_heart_inflammation0.44291190
120MP0002009_preneoplasia0.43867882
121MP0003448_altered_tumor_morphology0.43021511
122MP0005058_abnormal_lysosome_morphology0.41304886
123MP0004782_abnormal_surfactant_physiolog0.39968888
124MP0000858_altered_metastatic_potential0.38954735

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.46476794
2* Acanthosis nigricans (HP:0000956)6.35867805
3* Hypertriglyceridemia (HP:0002155)5.59226172
4Protrusio acetabuli (HP:0003179)5.41922885
5Insulin-resistant diabetes mellitus (HP:0000831)5.26844737
6Abnormality of glycine metabolism (HP:0010895)5.12569299
7Abnormality of serine family amino acid metabolism (HP:0010894)5.12569299
8* Oligomenorrhea (HP:0000876)4.84686457
9Myoglobinuria (HP:0002913)4.57427674
10Long foot (HP:0001833)4.52739380
11Difficulty running (HP:0009046)4.29733944
12Abnormality of fatty-acid metabolism (HP:0004359)4.11637935
13Complement deficiency (HP:0004431)4.10821387
14Reduced subcutaneous adipose tissue (HP:0003758)3.97536645
15Hypoglycemic coma (HP:0001325)3.90108544
16Increased muscle lipid content (HP:0009058)3.88714924
17Pigmentary retinal degeneration (HP:0001146)3.88284074
18Insulin resistance (HP:0000855)3.83893428
19Abnormality of proline metabolism (HP:0010907)3.81526521
20Hydroxyprolinuria (HP:0003080)3.81526521
21Rhabdomyolysis (HP:0003201)3.75225243
22Bone cyst (HP:0012062)3.72670359
23Growth hormone excess (HP:0000845)3.72422585
24Increased connective tissue (HP:0009025)3.68791687
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.54582178
26Vertebral compression fractures (HP:0002953)3.46040841
27Thyroid-stimulating hormone excess (HP:0002925)3.42741203
28Aortic aneurysm (HP:0004942)3.35724541
29Ketoacidosis (HP:0001993)3.35496604
30Hemorrhage of the eye (HP:0011885)3.33451300
31Dicarboxylic aciduria (HP:0003215)3.32485235
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.32485235
33Subcapsular cataract (HP:0000523)3.32178457
34Back pain (HP:0003418)3.31259090
35Nausea (HP:0002018)3.30507740
36Polycythemia (HP:0001901)3.28318232
37Hyperthyroidism (HP:0000836)3.28049737
38Hypoalphalipoproteinemia (HP:0003233)3.26878486
39Large hands (HP:0001176)3.18348220
40Ectopia lentis (HP:0001083)3.15173578
41Epidermoid cyst (HP:0200040)3.09784422
42Ketosis (HP:0001946)3.08387537
43Axonal loss (HP:0003447)3.06844271
44Ankle contracture (HP:0006466)3.01814093
45Hyperpituitarism (HP:0010514)3.01043750
46Hyperglycinemia (HP:0002154)2.99676822
47Multiple enchondromatosis (HP:0005701)2.98867115
48Myocardial infarction (HP:0001658)2.94519938
49Increased variability in muscle fiber diameter (HP:0003557)2.90570908
50Broad metatarsal (HP:0001783)2.88914447
51Abnormality of complement system (HP:0005339)2.87422731
52Striae distensae (HP:0001065)2.86516859
53Colitis (HP:0002583)2.85961121
54Pancreatitis (HP:0001733)2.82154266
55Type 1 muscle fiber predominance (HP:0003803)2.81383367
56Cervical subluxation (HP:0003308)2.72795831
57Hyperammonemia (HP:0001987)2.72398442
58Spinal rigidity (HP:0003306)2.67665790
59Follicular hyperkeratosis (HP:0007502)2.67198518
60Prenatal maternal abnormality (HP:0002686)2.67083636
61Accelerated skeletal maturation (HP:0005616)2.65057666
62Shallow orbits (HP:0000586)2.64578487
63Cerebral aneurysm (HP:0004944)2.64377407
64Ileus (HP:0002595)2.63884229
65Facial diplegia (HP:0001349)2.62859265
66Lymphangioma (HP:0100764)2.60197850
67Frequent falls (HP:0002359)2.59050144
68Neck muscle weakness (HP:0000467)2.55656081
69Hyperlipoproteinemia (HP:0010980)2.49733440
70Vascular tortuosity (HP:0004948)2.48505577
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47276608
72Abnormality of alanine metabolism (HP:0010916)2.47276608
73Hyperalaninemia (HP:0003348)2.47276608
74Abnormality of skeletal muscle fiber size (HP:0012084)2.45034875
75Tetraparesis (HP:0002273)2.43139147
76Prominent supraorbital ridges (HP:0000336)2.42478108
77Toxemia of pregnancy (HP:0100603)2.39474683
78Muscle fiber splitting (HP:0003555)2.39187447
79Decreased subcutaneous fat (HP:0001002)2.38280842
80Wormian bones (HP:0002645)2.33812859
81Infantile muscular hypotonia (HP:0008947)2.33174251
82Limb hypertonia (HP:0002509)2.32741909
83Hepatic necrosis (HP:0002605)2.32274222
84Generalized aminoaciduria (HP:0002909)2.27639286
85Skin nodule (HP:0200036)2.27613545
86Abnormal eating behavior (HP:0100738)2.27494138
87Pulmonary artery stenosis (HP:0004415)2.24212352
88Abnormal cartilage morphology (HP:0002763)2.23616472
89Dilatation of the ascending aorta (HP:0005111)2.21723824
90Mitral valve prolapse (HP:0001634)2.19615546
91Hyperglycemia (HP:0003074)2.19061124
92Muscle stiffness (HP:0003552)2.18858361
93Premature rupture of membranes (HP:0001788)2.18672032
94Easy fatigability (HP:0003388)2.18071619
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17688236
96Gowers sign (HP:0003391)2.16202850
97Renal cortical cysts (HP:0000803)2.15207131
98Increased serum pyruvate (HP:0003542)2.14143839
99Esophageal varix (HP:0002040)2.13624143
100Clitoromegaly (HP:0000057)2.13507383
101Slender build (HP:0001533)2.13491714
102Abnormality of subcutaneous fat tissue (HP:0001001)2.10293617
103Enlarged penis (HP:0000040)2.10088967
104Polar cataract (HP:0010696)2.09505726
105Polygenic inheritance (HP:0010982)2.08701737
106Neonatal hypoglycemia (HP:0001998)2.07190536
107Asymmetric septal hypertrophy (HP:0001670)2.04469750
108Testicular atrophy (HP:0000029)2.03487871
109Polyphagia (HP:0002591)2.01736966
110Xanthomatosis (HP:0000991)2.01603294
111Proximal amyotrophy (HP:0007126)2.00839245
112Joint hemorrhage (HP:0005261)2.00757655
113Hypercholesterolemia (HP:0003124)2.00749442
114Abnormality of the periventricular white matter (HP:0002518)2.00502114
115Venous abnormality (HP:0002624)1.99999282
116Abnormal hemoglobin (HP:0011902)1.96395182
117Fibular hypoplasia (HP:0003038)1.96162574
118Autoimmune thrombocytopenia (HP:0001973)1.94486614
119Arterial tortuosity (HP:0005116)1.94347752
120Systemic lupus erythematosus (HP:0002725)1.93918635
121Prolonged bleeding time (HP:0003010)1.93560607
122Myotonia (HP:0002486)1.93390416
123Increased mean platelet volume (HP:0011877)1.92693931
124Hyporeflexia of lower limbs (HP:0002600)1.92553414
125Soft skin (HP:0000977)1.91293945
126Gonadotropin excess (HP:0000837)1.91147214
127Conjunctival hamartoma (HP:0100780)1.88314817
128Abnormality of glycolysis (HP:0004366)1.87778577
129Atrioventricular block (HP:0001678)1.86398762
130Hypercortisolism (HP:0001578)1.86054849
131Aortic dissection (HP:0002647)1.86026778
132Gastrointestinal dysmotility (HP:0002579)1.83510383
133Hypoplasia of the iris (HP:0007676)1.83314984
134Turricephaly (HP:0000262)1.82627439
135Aneurysm (HP:0002617)1.80878769
136Foot dorsiflexor weakness (HP:0009027)1.80765694
137Megalocornea (HP:0000485)1.79321720
138Glucose intolerance (HP:0000833)1.79081037
139Overgrowth (HP:0001548)1.78520258
140Mutism (HP:0002300)1.78418882
141Aortic valve stenosis (HP:0001650)1.74664048
142Amyloidosis (HP:0011034)1.73801909
143Glomerulonephritis (HP:0000099)1.73731156
144Abnormality of serum amino acid levels (HP:0003112)1.73343382
145Nuclear cataract (HP:0100018)1.72510977
146Scapular winging (HP:0003691)1.71736486
147Coxa vara (HP:0002812)1.71199208
148Abnormal platelet volume (HP:0011876)1.70901275
149Spinal cord lesions (HP:0100561)1.70331004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D7.31973785
2CAMK1G5.32162832
3TRIB35.15673053
4SIK14.44700052
5BCKDK4.37147488
6PDK33.17566456
7PDK43.17566456
8TESK12.49756825
9LMTK22.48938867
10RIPK12.23856197
11MST1R2.23446259
12PRKAA22.10506496
13INSRR2.09647984
14PDK21.90687357
15ERN11.82440190
16CDK91.74857764
17EEF2K1.72466118
18GRK51.68780335
19FGFR31.63597142
20FRK1.62762311
21FGFR21.55372277
22MAP3K131.48318475
23RIPK41.37713128
24ARAF1.33972675
25PIK3CA1.31031945
26IRAK31.23886897
27EPHB21.22475556
28MOS1.20493490
29CDK61.18994096
30PDGFRA1.18478032
31TIE11.13815774
32JAK11.07914736
33TGFBR21.06840501
34MAP2K11.02487434
35MAP3K61.00628788
36PRKAA11.00370161
37KIT0.99708830
38PRKD30.97796793
39FES0.95768641
40LATS10.95688835
41ADRBK10.95202209
42KDR0.87582691
43TYK20.86840022
44PHKG20.86553290
45PHKG10.86553290
46MET0.85643874
47EIF2AK20.85264893
48PDPK10.85051870
49MAPK70.83978587
50STK38L0.81708455
51DDR20.78835350
52PRKCH0.77639036
53CDC42BPA0.76974099
54NEK90.76868500
55FGFR40.75149200
56PRKG10.74348967
57CAMK10.72986812
58PTK20.72230506
59PRPF4B0.71840369
60CAMKK20.71714886
61FER0.71140320
62JAK20.69050983
63PDK10.66270247
64PKN10.65369721
65MYLK0.65151454
66IGF1R0.64240375
67PINK10.62168792
68MTOR0.59137715
69JAK30.58031328
70MAPK110.57724045
71TNK20.56930654
72TTN0.55998152
73GSK3A0.55987147
74KSR20.55809910
75LATS20.55606941
76PDGFRB0.54762170
77PRKACB0.52586026
78IRAK10.52072166
79PRKD20.51911659
80CDK40.51537132
81ILK0.50294329
82RPS6KB10.47918327
83PTK2B0.47880389
84TBK10.47469209
85INSR0.47250361
86PRKD10.46668133
87* PRKACG0.46435046
88TYRO30.46141487
89STK380.44754272
90IRAK20.44697468
91RET0.43928930
92PAK40.43683660
93PKN20.43574085
94MAP3K70.43274136
95FGFR10.40585634
96YES10.40560060
97FLT30.40096048
98AKT20.39004121
99PRKG20.38954305
100CSF1R0.37688315
101DAPK30.37532083
102GRK10.36839897
103MAP3K10.36605453
104MARK20.36452154
105CLK10.36415645
106PAK20.36379178
107HIPK20.36060673
108BMX0.35813437
109MAPK10.33728868
110DMPK0.32092312
111ZAP700.31813879
112CAMKK10.31376745
113CSK0.31115774
114SRC0.30601375
115ABL20.30259448
116MAPKAPK50.30111984
117MAPK120.26969800
118AKT10.25128031
119STK110.24732179
120EPHA30.24534108
121ABL10.23099670
122MAP2K30.23072394
123STK30.20387149
124TEC0.19654418
125TRPM70.17708608
126DAPK20.15955779
127MAPK30.15476252
128SGK30.14268442
129EPHB10.13592413
130MAP2K40.13234522
131ICK0.12371703
132MAPK40.12031962
133MAPKAPK30.10281911
134OBSCN0.09685410
135NLK0.09369062
136PRKCE0.09209737
137CDK50.08693390
138* PRKACA0.08481451

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.30793724
2Propanoate metabolism_Homo sapiens_hsa006404.97521908
3* PPAR signaling pathway_Homo sapiens_hsa033204.17158680
4* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.17036490
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.03164499
6Fatty acid metabolism_Homo sapiens_hsa012123.79906465
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.78919436
8Glycerolipid metabolism_Homo sapiens_hsa005613.16693818
9Fatty acid degradation_Homo sapiens_hsa000713.08052878
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67248752
11Pyruvate metabolism_Homo sapiens_hsa006202.37709066
12Adipocytokine signaling pathway_Homo sapiens_hsa049202.26156243
13Histidine metabolism_Homo sapiens_hsa003402.19362298
14AMPK signaling pathway_Homo sapiens_hsa041522.12732333
15beta-Alanine metabolism_Homo sapiens_hsa004102.12329829
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81426515
17Carbon metabolism_Homo sapiens_hsa012001.80811280
18Fat digestion and absorption_Homo sapiens_hsa049751.74959938
19Peroxisome_Homo sapiens_hsa041461.51851578
20Caffeine metabolism_Homo sapiens_hsa002321.51034471
21Fatty acid elongation_Homo sapiens_hsa000621.48324573
22Butanoate metabolism_Homo sapiens_hsa006501.32113781
23Insulin resistance_Homo sapiens_hsa049311.30510018
24Insulin signaling pathway_Homo sapiens_hsa049101.30406743
25Vitamin B6 metabolism_Homo sapiens_hsa007501.19809978
26Phenylalanine metabolism_Homo sapiens_hsa003601.19296497
27Tyrosine metabolism_Homo sapiens_hsa003501.09224636
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03119889
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02336406
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01559439
31Nitrogen metabolism_Homo sapiens_hsa009101.01325153
32Staphylococcus aureus infection_Homo sapiens_hsa051501.00853620
33Glucagon signaling pathway_Homo sapiens_hsa049221.00398788
34Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98413120
35Glycerophospholipid metabolism_Homo sapiens_hsa005640.94100613
36Renin secretion_Homo sapiens_hsa049240.90254230
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85633351
38Sulfur relay system_Homo sapiens_hsa041220.85038729
39Pentose phosphate pathway_Homo sapiens_hsa000300.84740376
40ECM-receptor interaction_Homo sapiens_hsa045120.81162299
41Retinol metabolism_Homo sapiens_hsa008300.80847544
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75032162
43Tryptophan metabolism_Homo sapiens_hsa003800.74774104
44Type II diabetes mellitus_Homo sapiens_hsa049300.70823206
45Protein digestion and absorption_Homo sapiens_hsa049740.64413513
46ABC transporters_Homo sapiens_hsa020100.59731101
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59337284
48Dilated cardiomyopathy_Homo sapiens_hsa054140.58966808
49Notch signaling pathway_Homo sapiens_hsa043300.55650096
50Autoimmune thyroid disease_Homo sapiens_hsa053200.54823698
51Dorso-ventral axis formation_Homo sapiens_hsa043200.53249383
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.52259440
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51933903
54Glutathione metabolism_Homo sapiens_hsa004800.51348236
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48612347
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47328801
57Starch and sucrose metabolism_Homo sapiens_hsa005000.44658910
58Lysine degradation_Homo sapiens_hsa003100.44193611
59Vitamin digestion and absorption_Homo sapiens_hsa049770.43968563
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43727766
61Chemical carcinogenesis_Homo sapiens_hsa052040.43534843
62Focal adhesion_Homo sapiens_hsa045100.41870358
63Acute myeloid leukemia_Homo sapiens_hsa052210.40312308
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37727087
65HIF-1 signaling pathway_Homo sapiens_hsa040660.36469306
66Arachidonic acid metabolism_Homo sapiens_hsa005900.35014864
67Biosynthesis of amino acids_Homo sapiens_hsa012300.32821204
68Linoleic acid metabolism_Homo sapiens_hsa005910.32817933
69cAMP signaling pathway_Homo sapiens_hsa040240.30304473
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29566487
71Fructose and mannose metabolism_Homo sapiens_hsa000510.28720390
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28451368
73Adherens junction_Homo sapiens_hsa045200.28234916
74Arginine and proline metabolism_Homo sapiens_hsa003300.28049772
75Bile secretion_Homo sapiens_hsa049760.27888718
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27523379
77Rap1 signaling pathway_Homo sapiens_hsa040150.27156350
78Complement and coagulation cascades_Homo sapiens_hsa046100.27142645
79mTOR signaling pathway_Homo sapiens_hsa041500.27141516
80Morphine addiction_Homo sapiens_hsa050320.25999407
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25662092
82Folate biosynthesis_Homo sapiens_hsa007900.23595502
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23452394
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.23066711
85Sulfur metabolism_Homo sapiens_hsa009200.22699481
86Melanogenesis_Homo sapiens_hsa049160.21571786
87Circadian rhythm_Homo sapiens_hsa047100.21521339
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21260529
89Metabolic pathways_Homo sapiens_hsa011000.20354874
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19428318
91Small cell lung cancer_Homo sapiens_hsa052220.18675994
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18481502
93Melanoma_Homo sapiens_hsa052180.18431354
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16949952
95Salivary secretion_Homo sapiens_hsa049700.16666264
96Gap junction_Homo sapiens_hsa045400.16344393
97Thyroid cancer_Homo sapiens_hsa052160.16293882
98Estrogen signaling pathway_Homo sapiens_hsa049150.16245731
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15972013
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15763689
101Ovarian steroidogenesis_Homo sapiens_hsa049130.15735996
102Other glycan degradation_Homo sapiens_hsa005110.15083844
103Amoebiasis_Homo sapiens_hsa051460.14735862
104Proteoglycans in cancer_Homo sapiens_hsa052050.13906146
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.12205803
106GnRH signaling pathway_Homo sapiens_hsa049120.12080014
107Ras signaling pathway_Homo sapiens_hsa040140.11431677
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.11087543
109Lysosome_Homo sapiens_hsa041420.11075883
110Pertussis_Homo sapiens_hsa051330.10940511
111Viral myocarditis_Homo sapiens_hsa054160.10803974
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09356876
113Toxoplasmosis_Homo sapiens_hsa051450.08665733
114Arginine biosynthesis_Homo sapiens_hsa002200.07609840
115FoxO signaling pathway_Homo sapiens_hsa040680.07375422
116Platelet activation_Homo sapiens_hsa046110.06940195
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06858567
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.06150031
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.05178595
120Alzheimers disease_Homo sapiens_hsa050100.04549562
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.04373457
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.03934171
123Renin-angiotensin system_Homo sapiens_hsa046140.03139010
124Thyroid hormone synthesis_Homo sapiens_hsa049180.02677214
125Pathways in cancer_Homo sapiens_hsa052000.02099767
126Malaria_Homo sapiens_hsa051440.01206732
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.01167157
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.00166886
129Parkinsons disease_Homo sapiens_hsa05012-0.0208500
130Hepatitis C_Homo sapiens_hsa05160-0.0114056
131Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0064567
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0028651

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