PLIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)5.67638731
2cellular response to cadmium ion (GO:0071276)5.15440329
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.14517174
4alpha-linolenic acid metabolic process (GO:0036109)5.00376411
5peptidyl-glutamic acid carboxylation (GO:0017187)4.57886512
6protein carboxylation (GO:0018214)4.57886512
7plasma lipoprotein particle clearance (GO:0034381)4.56784522
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.56146328
9L-phenylalanine catabolic process (GO:0006559)4.56146328
10low-density lipoprotein particle clearance (GO:0034383)4.48219720
11L-phenylalanine metabolic process (GO:0006558)4.46371524
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.46371524
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36141925
14regulation of triglyceride catabolic process (GO:0010896)4.31610050
15aromatic amino acid family catabolic process (GO:0009074)4.29582077
16complement activation, alternative pathway (GO:0006957)4.20899746
17urea cycle (GO:0000050)4.14127199
18urea metabolic process (GO:0019627)4.14127199
19regulation of cholesterol storage (GO:0010885)4.10554542
20kynurenine metabolic process (GO:0070189)4.08382185
21negative regulation of fibrinolysis (GO:0051918)4.08178675
22tryptophan catabolic process (GO:0006569)4.07982943
23indole-containing compound catabolic process (GO:0042436)4.07982943
24indolalkylamine catabolic process (GO:0046218)4.07982943
25high-density lipoprotein particle remodeling (GO:0034375)4.05108378
26oligosaccharide catabolic process (GO:0009313)4.05057760
27regulation of sequestering of triglyceride (GO:0010889)4.04003736
28phospholipid efflux (GO:0033700)3.97031515
29bile acid biosynthetic process (GO:0006699)3.95243320
30sulfur amino acid catabolic process (GO:0000098)3.94188680
31negative regulation of fatty acid biosynthetic process (GO:0045717)3.93508341
32tryptophan metabolic process (GO:0006568)3.90261857
33regulation of cholesterol esterification (GO:0010872)3.89670104
34aldehyde catabolic process (GO:0046185)3.87709930
35regulation of protein activation cascade (GO:2000257)3.86764337
36reverse cholesterol transport (GO:0043691)3.84504315
37cysteine metabolic process (GO:0006534)3.83411086
38glyoxylate metabolic process (GO:0046487)3.80388420
39regulation of cholesterol homeostasis (GO:2000188)3.78928621
40nitrogen cycle metabolic process (GO:0071941)3.78647259
41protein-lipid complex remodeling (GO:0034368)3.72568304
42macromolecular complex remodeling (GO:0034367)3.72568304
43plasma lipoprotein particle remodeling (GO:0034369)3.72568304
44regulation of fibrinolysis (GO:0051917)3.71426028
45cellular response to thyroid hormone stimulus (GO:0097067)3.67661992
46regulation of complement activation (GO:0030449)3.66632647
47acylglycerol homeostasis (GO:0055090)3.61196373
48triglyceride homeostasis (GO:0070328)3.61196373
49positive regulation of lipid catabolic process (GO:0050996)3.57639457
50positive regulation of extracellular matrix organization (GO:1903055)3.56720010
51phospholipid homeostasis (GO:0055091)3.55798220
52amino-acid betaine metabolic process (GO:0006577)3.54285931
53cholesterol efflux (GO:0033344)3.53146740
54L-ascorbic acid metabolic process (GO:0019852)3.49358259
55fibrinolysis (GO:0042730)3.44063087
56regulation of metalloenzyme activity (GO:0048552)3.42742451
57bile acid metabolic process (GO:0008206)3.41094035
58plasma lipoprotein particle assembly (GO:0034377)3.39606546
59glycosphingolipid catabolic process (GO:0046479)3.37313628
60positive regulation of triglyceride lipase activity (GO:0061365)3.36658472
61positive regulation of lipoprotein lipase activity (GO:0051006)3.36658472
62negative regulation of endothelial cell apoptotic process (GO:2000352)3.34462729
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.33602991
64fatty acid beta-oxidation (GO:0006635)3.31874785
65homocysteine metabolic process (GO:0050667)3.31222816
66positive regulation of cholesterol efflux (GO:0010875)3.27881679
67lysine metabolic process (GO:0006553)3.24693784
68lysine catabolic process (GO:0006554)3.24693784
69ethanol oxidation (GO:0006069)3.20510862
70fatty acid oxidation (GO:0019395)3.20146849
71lipoprotein metabolic process (GO:0042157)3.19911991
72positive regulation of lipid storage (GO:0010884)3.18123036
73lipid oxidation (GO:0034440)3.16879112
74protein-lipid complex assembly (GO:0065005)3.16826367
75regulation of cytokine secretion involved in immune response (GO:0002739)3.16765766
76COPII vesicle coating (GO:0048208)3.16763194
77low-density lipoprotein particle remodeling (GO:0034374)3.16586575
78cholesterol transport (GO:0030301)3.15818369
79sterol transport (GO:0015918)3.15818369
80very-low-density lipoprotein particle assembly (GO:0034379)3.13648593
81plasma lipoprotein particle organization (GO:0071827)3.13287982
82negative regulation of cholesterol transport (GO:0032375)3.13167036
83negative regulation of sterol transport (GO:0032372)3.13167036
84response to thyroid hormone (GO:0097066)3.12761717
85negative regulation of lipase activity (GO:0060192)3.12542054
86acute-phase response (GO:0006953)3.12536138
87aromatic amino acid family metabolic process (GO:0009072)3.11861934
88positive regulation of triglyceride metabolic process (GO:0090208)3.11527043
89positive regulation of blood coagulation (GO:0030194)3.09271638
90positive regulation of hemostasis (GO:1900048)3.09271638
91cofactor catabolic process (GO:0051187)3.08757280
92regulation of plasminogen activation (GO:0010755)3.08609460
93tyrosine metabolic process (GO:0006570)3.07441730
944-hydroxyproline metabolic process (GO:0019471)3.07155248
95regulation of lipid storage (GO:0010883)3.07150201
96fatty acid catabolic process (GO:0009062)3.06822452
97fat-soluble vitamin biosynthetic process (GO:0042362)3.06758579
98glycolipid catabolic process (GO:0019377)3.05910719
99serine family amino acid catabolic process (GO:0009071)3.05838128
100positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.05576224
101carnitine metabolic process (GO:0009437)3.03564816
102cholesterol homeostasis (GO:0042632)3.03305160
103fatty acid transmembrane transport (GO:1902001)3.02639342
104protein-lipid complex subunit organization (GO:0071825)3.01758753
105positive regulation of coagulation (GO:0050820)3.01415735
106sterol homeostasis (GO:0055092)3.00851076
107positive regulation of cholesterol transport (GO:0032376)3.00550843
108positive regulation of sterol transport (GO:0032373)3.00550843
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.99416609
110pinocytosis (GO:0006907)2.98290495
111cellular response to arsenic-containing substance (GO:0071243)2.97720549
112regulation of macrophage derived foam cell differentiation (GO:0010743)2.97260041
113progesterone metabolic process (GO:0042448)2.97103369
114regulation of lipoprotein lipase activity (GO:0051004)2.96956143
115acetyl-CoA metabolic process (GO:0006084)2.96019012
116regulation of cholesterol metabolic process (GO:0090181)2.94500379
117negative regulation of protein activation cascade (GO:2000258)2.92794596
118negative regulation of lipid storage (GO:0010888)2.91568811
119monocarboxylic acid catabolic process (GO:0072329)2.90908985
120valine metabolic process (GO:0006573)2.90638931
121positive regulation of fatty acid oxidation (GO:0046321)2.90444540
122positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90028979
123ceramide catabolic process (GO:0046514)2.89860730
124cellular glucuronidation (GO:0052695)2.88832737
125peptidyl-proline hydroxylation (GO:0019511)2.88645631
126uronic acid metabolic process (GO:0006063)2.88153823
127glucuronate metabolic process (GO:0019585)2.88153823
128benzene-containing compound metabolic process (GO:0042537)2.88123864
129nicotinamide nucleotide biosynthetic process (GO:0019359)2.87705157
130pyridine nucleotide biosynthetic process (GO:0019363)2.87705157
131negative regulation of coagulation (GO:0050819)2.87181432
132regulation of triglyceride metabolic process (GO:0090207)2.87164017
133regulation of endothelial cell apoptotic process (GO:2000351)2.87096443
134negative regulation of protein autophosphorylation (GO:0031953)2.85083058
135alpha-amino acid catabolic process (GO:1901606)2.84120472
136positive regulation of monocyte chemotaxis (GO:0090026)2.82405629
137response to nitrosative stress (GO:0051409)2.82297459
138nucleotide-sugar biosynthetic process (GO:0009226)2.81999106
139apoptotic cell clearance (GO:0043277)2.81087776
140intestinal cholesterol absorption (GO:0030299)2.80883133
141negative regulation of blood coagulation (GO:0030195)2.80120005
142negative regulation of hemostasis (GO:1900047)2.80120005
143positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80043018
144protein hydroxylation (GO:0018126)2.74898635
145regulation of fatty acid biosynthetic process (GO:0042304)2.73772145
146UDP-N-acetylglucosamine metabolic process (GO:0006047)2.73231963
147hemoglobin metabolic process (GO:0020027)2.70902454
148amino sugar catabolic process (GO:0046348)2.69919688
149negative regulation of macrophage differentiation (GO:0045650)2.64832165
150positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64608677
151regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64248160
152regulation of integrin-mediated signaling pathway (GO:2001044)2.62515591
153negative regulation of lipid transport (GO:0032369)2.62139364
154regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.62125545
155endocrine hormone secretion (GO:0060986)2.60330738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.98394724
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.02511542
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.70716280
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.05079789
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.52806292
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.41460342
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.63971217
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55788020
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.54132583
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.13469447
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86623394
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.67894938
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.60609326
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.56527479
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46930754
16CLOCK_20551151_ChIP-Seq_293T_Human2.37891453
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.30058031
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28559956
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25272350
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.16029607
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12736575
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12309390
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11047679
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09929560
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01223005
26GATA1_22025678_ChIP-Seq_K562_Human1.89617247
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88595889
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78554735
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68824023
30* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65434962
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59096660
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57480158
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56562332
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55254147
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49516569
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47081522
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.45910965
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.44749186
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43335447
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41920461
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.37617310
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35022100
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30558333
44CJUN_26792858_Chip-Seq_BT549_Human1.29075640
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25343593
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23884309
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20669340
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.20528697
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.18171568
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15253582
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14747237
52* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08957492
53* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07779248
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04016598
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.03635295
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03169006
57GATA4_25053715_ChIP-Seq_YYC3_Human1.02757011
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02753813
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01042816
60FOXA2_19822575_ChIP-Seq_HepG2_Human0.97520899
61SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97344601
62SOX2_20726797_ChIP-Seq_SW620_Human0.96376513
63ZNF263_19887448_ChIP-Seq_K562_Human0.95470228
64FOXO3_23340844_ChIP-Seq_DLD1_Human0.95303435
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95279237
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94456742
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.94370549
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93425481
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93425481
70* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93194498
71* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93194498
72* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92488961
73HNF4A_19822575_ChIP-Seq_HepG2_Human0.92240556
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91937982
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91889959
76TFEB_21752829_ChIP-Seq_HELA_Human0.90410431
77* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90216901
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.89226056
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.88897629
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88071916
81ESR1_20079471_ChIP-ChIP_T-47D_Human0.87985294
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87396087
83UBF1/2_26484160_Chip-Seq_HMECs_Human0.85326609
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84607412
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84101220
86P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84068037
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83556680
88PU_27001747_Chip-Seq_BMDM_Mouse0.83379502
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83064262
90VDR_24787735_ChIP-Seq_THP-1_Human0.82750363
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81372760
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81326036
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80283390
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79553894
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78241097
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77690427
97SPI1_23547873_ChIP-Seq_NB4_Human0.77557170
98* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77222782
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77218461
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77202672
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77095056
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76859338
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76859338
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75867271
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75639547
106ATF3_27146783_Chip-Seq_COLON_Human0.75550126
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75002792
108RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74968888
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74704332
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74213271
111GATA1_19941826_ChIP-Seq_K562_Human0.73709725
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73656677
113LXR_22292898_ChIP-Seq_THP-1_Human0.73489431
114GATA2_19941826_ChIP-Seq_K562_Human0.73020410
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72367620
116RACK7_27058665_Chip-Seq_MCF-7_Human0.71391873
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71294119
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70383062
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70311575
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69611840
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.69545670
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69420947
123VDR_24763502_ChIP-Seq_THP-1_Human0.69254637
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.69018593
125GATA6_25053715_ChIP-Seq_YYC3_Human0.68255686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.36111360
2MP0003950_abnormal_plasma_membrane4.70846468
3MP0005360_urolithiasis4.64876156
4MP0005365_abnormal_bile_salt4.11617452
5MP0005085_abnormal_gallbladder_physiolo3.84585115
6MP0009840_abnormal_foam_cell3.61883968
7MP0003191_abnormal_cellular_cholesterol3.19978410
8MP0008875_abnormal_xenobiotic_pharmacok3.13814540
9MP0010329_abnormal_lipoprotein_level3.01331963
10MP0003806_abnormal_nucleotide_metabolis2.77182642
11MP0005058_abnormal_lysosome_morphology2.48326240
12MP0006054_spinal_hemorrhage2.46380020
13MP0003252_abnormal_bile_duct2.41585519
14MP0005083_abnormal_biliary_tract2.39467208
15MP0004272_abnormal_basement_membrane2.08471098
16MP0003436_decreased_susceptibility_to2.07073202
17MP0005670_abnormal_white_adipose2.03492064
18MP0003705_abnormal_hypodermis_morpholog2.00417779
19MP0008438_abnormal_cutaneous_collagen1.97191781
20MP0003195_calcinosis1.96365637
21* MP0000609_abnormal_liver_physiology1.95691125
22MP0003186_abnormal_redox_activity1.91292006
23MP0005332_abnormal_amino_acid1.90437532
24* MP0002118_abnormal_lipid_homeostasis1.80365982
25MP0003279_aneurysm1.76327361
26MP0002138_abnormal_hepatobiliary_system1.70960344
27MP0001835_abnormal_antigen_presentation1.69737595
28MP0003724_increased_susceptibility_to1.65726308
29MP0001666_abnormal_nutrient_absorption1.65591296
30MP0005319_abnormal_enzyme/_coenzyme1.62601751
31MP0004130_abnormal_muscle_cell1.59657578
32* MP0004019_abnormal_vitamin_homeostasis1.56912794
33MP0002419_abnormal_innate_immunity1.52610015
34MP0006082_CNS_inflammation1.51652348
35MP0002254_reproductive_system_inflammat1.49853277
36MP0009764_decreased_sensitivity_to1.44356162
37MP0009785_altered_susceptibility_to1.43099373
38MP0005584_abnormal_enzyme/coenzyme_acti1.43092236
39MP0003303_peritoneal_inflammation1.42505871
40MP0000604_amyloidosis1.39288094
41MP0003656_abnormal_erythrocyte_physiolo1.38245517
42MP0008469_abnormal_protein_level1.38144973
43MP0008260_abnormal_autophagy1.37308216
44MP0005666_abnormal_adipose_tissue1.36042688
45MP0005464_abnormal_platelet_physiology1.27775942
46MP0001879_abnormal_lymphatic_vessel1.27409863
47MP0009643_abnormal_urine_homeostasis1.24194792
48MP0000343_altered_response_to1.23034680
49MP0001853_heart_inflammation1.22178513
50MP0001533_abnormal_skeleton_physiology1.22032083
51MP0004233_abnormal_muscle_weight1.21856701
52MP0002971_abnormal_brown_adipose1.21602789
53MP0005025_abnormal_response_to1.21160863
54MP0003690_abnormal_glial_cell1.20517187
55MP0005451_abnormal_body_composition1.19966687
56MP0009763_increased_sensitivity_to1.19920876
57MP0001915_intracranial_hemorrhage1.17768269
58MP0000598_abnormal_liver_morphology1.16146516
59* MP0001881_abnormal_mammary_gland1.15932738
60MP0003172_abnormal_lysosome_physiology1.14614292
61MP0004883_abnormal_blood_vessel1.14406467
62MP0002933_joint_inflammation1.13759392
63MP0002148_abnormal_hypersensitivity_rea1.13264908
64MP0004185_abnormal_adipocyte_glucose1.12801196
65MP0003828_pulmonary_edema1.11365556
66MP0002876_abnormal_thyroid_physiology1.10125442
67MP0003300_gastrointestinal_ulcer1.08226373
68MP0001764_abnormal_homeostasis1.07301711
69MP0003566_abnormal_cell_adhesion1.07236052
70MP0004782_abnormal_surfactant_physiolog1.03107195
71MP0001845_abnormal_inflammatory_respons1.02454278
72MP0004947_skin_inflammation1.01233638
73MP0005334_abnormal_fat_pad1.00225584
74MP0005000_abnormal_immune_tolerance0.97671164
75MP0008004_abnormal_stomach_pH0.96880730
76MP0005165_increased_susceptibility_to0.96457967
77MP0009697_abnormal_copulation0.95093253
78MP0009115_abnormal_fat_cell0.94456414
79MP0005164_abnormal_response_to0.94328079
80MP0005275_abnormal_skin_tensile0.94067150
81MP0005023_abnormal_wound_healing0.91716734
82MP0005387_immune_system_phenotype0.90969501
83MP0001790_abnormal_immune_system0.90969501
84MP0003075_altered_response_to0.89370132
85MP0003221_abnormal_cardiomyocyte_apopto0.88650900
86MP0000767_abnormal_smooth_muscle0.88493068
87MP0000685_abnormal_immune_system0.85944429
88MP0002452_abnormal_antigen_presenting0.85120654
89MP0003091_abnormal_cell_migration0.83933757
90MP0005408_hypopigmentation0.81949923
91MP0010368_abnormal_lymphatic_system0.81174483
92MP0001756_abnormal_urination0.81024594
93MP0001661_extended_life_span0.80831218
94MP0005375_adipose_tissue_phenotype0.80737765
95MP0003329_amyloid_beta_deposits0.79704831
96MP0002136_abnormal_kidney_physiology0.79091295
97MP0009642_abnormal_blood_homeostasis0.78168939
98MP0003453_abnormal_keratinocyte_physiol0.77747572
99MP0005166_decreased_susceptibility_to0.77561196
100MP0000858_altered_metastatic_potential0.74952394
101MP0003448_altered_tumor_morphology0.74842095
102MP0005397_hematopoietic_system_phenotyp0.73485558
103MP0001545_abnormal_hematopoietic_system0.73485558
104MP0002060_abnormal_skin_morphology0.73168501
105MP0000003_abnormal_adipose_tissue0.73009928
106MP0005595_abnormal_vascular_smooth0.73001788
107MP0002723_abnormal_immune_serum0.72985323
108MP0002998_abnormal_bone_remodeling0.72494272
109MP0000249_abnormal_blood_vessel0.72334332
110MP0004510_myositis0.72314614
111MP0000371_diluted_coat_color0.71447357
112MP0002405_respiratory_system_inflammati0.70773913
113MP0005636_abnormal_mineral_homeostasis0.70050885
114MP0001800_abnormal_humoral_immune0.69651880
115MP0005257_abnormal_intraocular_pressure0.69317530
116MP0005376_homeostasis/metabolism_phenot0.68834607
117MP0002796_impaired_skin_barrier0.68216782
118MP0003868_abnormal_feces_composition0.66849783
119MP0009333_abnormal_splenocyte_physiolog0.66074265
120MP0002970_abnormal_white_adipose0.64554466
121MP0005167_abnormal_blood-brain_barrier0.64543279
122MP0005647_abnormal_sex_gland0.63502520
123MP0000920_abnormal_myelination0.62942982
124MP0005410_abnormal_fertilization0.62865859
125MP0002295_abnormal_pulmonary_circulatio0.62345713
126MP0005535_abnormal_body_temperature0.62158214
127MP0010155_abnormal_intestine_physiology0.62102098
128MP0001243_abnormal_dermal_layer0.61632772

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.64112849
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.64112849
3Abnormality of glycolipid metabolism (HP:0010969)5.64112849
4Xanthomatosis (HP:0000991)5.17500910
5Deep venous thrombosis (HP:0002625)5.13832096
6Complement deficiency (HP:0004431)4.54972830
7Intrahepatic cholestasis (HP:0001406)4.54495300
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45744876
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.30848633
10Joint hemorrhage (HP:0005261)4.26742682
11Prolonged partial thromboplastin time (HP:0003645)4.23024438
12Hyperlipoproteinemia (HP:0010980)4.18175408
13Systemic lupus erythematosus (HP:0002725)4.12863853
14Hypobetalipoproteinemia (HP:0003563)4.04044292
15Recurrent gram-negative bacterial infections (HP:0005420)3.99098414
16Myocardial infarction (HP:0001658)3.94501690
17Abnormality of complement system (HP:0005339)3.80326034
18Hypoalphalipoproteinemia (HP:0003233)3.72238713
19Hypolipoproteinemia (HP:0010981)3.65410264
20Epidermoid cyst (HP:0200040)3.60391430
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57793653
22Abnormality of the common coagulation pathway (HP:0010990)3.52015218
23Hypercholesterolemia (HP:0003124)3.45961467
24Hyperammonemia (HP:0001987)3.45538655
25Vacuolated lymphocytes (HP:0001922)3.39336041
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.33358966
27Hypoglycemic coma (HP:0001325)3.18744874
28Abnormality of fatty-acid metabolism (HP:0004359)3.13834689
29Axonal loss (HP:0003447)3.13554706
30Cholecystitis (HP:0001082)3.07379799
31Abnormal gallbladder physiology (HP:0012438)3.07379799
32Increased cerebral lipofuscin (HP:0011813)3.04582955
33Hyperglycinuria (HP:0003108)3.02180454
34Glomerulonephritis (HP:0000099)2.94834849
35Purpura (HP:0000979)2.85519634
36Fat malabsorption (HP:0002630)2.84241822
37Increased serum pyruvate (HP:0003542)2.84032548
38Ketosis (HP:0001946)2.84021655
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83120464
40Eczematoid dermatitis (HP:0000976)2.81234629
41Nausea (HP:0002018)2.81170384
42Abnormality of glycine metabolism (HP:0010895)2.79404763
43Abnormality of serine family amino acid metabolism (HP:0010894)2.79404763
44Abnormality of the intrinsic pathway (HP:0010989)2.74617311
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.74311945
46Rhabdomyolysis (HP:0003201)2.73994164
47Esophageal varix (HP:0002040)2.72083453
48Hyperglycinemia (HP:0002154)2.71861094
49Skin nodule (HP:0200036)2.70926568
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65684716
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.65176041
52Recurrent bacterial skin infections (HP:0005406)2.64187523
53Follicular hyperkeratosis (HP:0007502)2.64049446
54Nephritis (HP:0000123)2.61614650
55Abnormality of methionine metabolism (HP:0010901)2.60981113
56Tetraparesis (HP:0002273)2.58313989
57Recurrent abscess formation (HP:0002722)2.58278216
58Abnormality of purine metabolism (HP:0004352)2.58045990
59Abnormality of glycolysis (HP:0004366)2.56830187
60Abnormality of nucleobase metabolism (HP:0010932)2.55286402
61Hepatocellular carcinoma (HP:0001402)2.52588425
62Abnormality of pyrimidine metabolism (HP:0004353)2.49767228
63Abnormality of proline metabolism (HP:0010907)2.46663027
64Hydroxyprolinuria (HP:0003080)2.46663027
65Abnormality of iron homeostasis (HP:0011031)2.45920266
66Autoimmune thrombocytopenia (HP:0001973)2.45703102
67Retinal atrophy (HP:0001105)2.43714562
68Vertebral compression fractures (HP:0002953)2.42114546
69Abnormality of macrophages (HP:0004311)2.40868955
70Amyloidosis (HP:0011034)2.40691124
71Hypertriglyceridemia (HP:0002155)2.40640643
72Gingival bleeding (HP:0000225)2.37125259
73Premature rupture of membranes (HP:0001788)2.34901487
74Steatorrhea (HP:0002570)2.33661303
75Neurofibrillary tangles (HP:0002185)2.33159407
76Abnormality of the periventricular white matter (HP:0002518)2.30510617
77Increased serum ferritin (HP:0003281)2.29951697
78Dicarboxylic aciduria (HP:0003215)2.27049568
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27049568
80Dysostosis multiplex (HP:0000943)2.26120641
81Abnormality of transition element cation homeostasis (HP:0011030)2.24366791
82Cervical subluxation (HP:0003308)2.23848380
83Hemorrhage of the eye (HP:0011885)2.21348675
84Menorrhagia (HP:0000132)2.19408005
85Hyperbilirubinemia (HP:0002904)2.19158082
86Urinary glycosaminoglycan excretion (HP:0003541)2.15105485
87Mucopolysacchariduria (HP:0008155)2.15105485
88Spastic diplegia (HP:0001264)2.13655469
89Vascular calcification (HP:0004934)2.10845240
90Upper motor neuron abnormality (HP:0002127)2.07349803
91Polycythemia (HP:0001901)2.07134250
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06123597
93Abnormal cartilage morphology (HP:0002763)2.05188568
94Abnormality of serum amino acid levels (HP:0003112)2.04291419
95Spontaneous abortion (HP:0005268)2.02982915
96Ovoid vertebral bodies (HP:0003300)2.02972738
97Mitral stenosis (HP:0001718)2.02326420
98Increased CSF protein (HP:0002922)2.01777618
99Hepatosplenomegaly (HP:0001433)2.01733323
100Sensorimotor neuropathy (HP:0007141)2.00827766
101Pancreatitis (HP:0001733)2.00415041
102Conjugated hyperbilirubinemia (HP:0002908)1.99307007
103Cardiovascular calcification (HP:0011915)1.99171237
104Ketoacidosis (HP:0001993)1.97930978
105Mediastinal lymphadenopathy (HP:0100721)1.96351393
106Cholelithiasis (HP:0001081)1.96040152
107Abnormality of polysaccharide metabolism (HP:0011012)1.95951010
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95951010
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95951010
110Generalized aminoaciduria (HP:0002909)1.95523892
111Peritonitis (HP:0002586)1.95170303
112Metaphyseal irregularity (HP:0003025)1.93907093
113Asymmetric septal hypertrophy (HP:0001670)1.93798525
114Increased mean platelet volume (HP:0011877)1.93736767
115Type 1 muscle fiber predominance (HP:0003803)1.92331282
116Abnormal gallbladder morphology (HP:0012437)1.90483037
117Pathologic fracture (HP:0002756)1.90402164
118Myoglobinuria (HP:0002913)1.89779668
119Loss of speech (HP:0002371)1.89319717
120Abnormality of carpal bone ossification (HP:0006257)1.87614510
121Metabolic acidosis (HP:0001942)1.86669143
122Conjunctival telangiectasia (HP:0000524)1.86562070
123Lethargy (HP:0001254)1.84880902
124Metaphyseal dysplasia (HP:0100255)1.84819704
125Esophageal neoplasm (HP:0100751)1.84754143
126Neoplasm of head and neck (HP:0012288)1.84754143
127Blue sclerae (HP:0000592)1.84667831
128Delayed closure of the anterior fontanelle (HP:0001476)1.83703770
129Recurrent skin infections (HP:0001581)1.82390002
130Thrombophlebitis (HP:0004418)1.82304991
131Osteolytic defects of the hand bones (HP:0009699)1.81737294
132Beaking of vertebral bodies (HP:0004568)1.81722956
133Peripheral demyelination (HP:0011096)1.81702206
134Glomerulopathy (HP:0100820)1.80643434
135Protrusio acetabuli (HP:0003179)1.79384248
136Nuclear cataract (HP:0100018)1.76416675
137Spondylolisthesis (HP:0003302)1.75173718
138Mesangial abnormality (HP:0001966)1.68257930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.06777140
2DDR23.67902284
3BCKDK3.53697443
4TRIB33.33458129
5STK242.69674511
6ACVR1B2.68249834
7TBK12.66969658
8SIK12.52622447
9IRAK32.51884041
10EIF2AK32.47256078
11ARAF2.41499812
12AKT32.41219132
13NEK92.37989010
14TYK22.37030996
15MAP4K22.33703169
16FGFR42.31026988
17TGFBR22.20118161
18CAMK1D2.16255689
19PKN22.16015286
20PBK2.15819398
21MAP3K142.04996881
22NME22.03276146
23TAOK32.01989955
24MST1R2.00036818
25ABL21.81403491
26KIT1.65682759
27BLK1.62600535
28PIM21.48207546
29JAK11.42364894
30PTK61.39674328
31KDR1.37061637
32MAP3K31.35041027
33MAP2K31.34414571
34EPHA21.31712647
35TTN1.31445838
36LATS21.30291948
37MAP4K11.27872080
38IKBKE1.25575879
39BMX1.24818496
40RIPK11.24685355
41NLK1.24038787
42EPHB11.23477210
43LRRK21.16798862
44ERBB41.15703105
45PIK3CG1.15508307
46FLT31.15400144
47IKBKB1.14850489
48PRPF4B1.14371353
49CSK1.13095900
50FGFR11.12128751
51IRAK41.09954402
52KSR21.08022509
53MAP3K91.06938536
54STK101.06677799
55JAK31.06518289
56MAP3K111.06455866
57MET1.04914056
58CSF1R1.03268634
59JAK21.02388386
60GRK71.02058674
61CLK11.01992656
62RPS6KA41.00651563
63CDK61.00065823
64ZAP700.98892971
65CAMK1G0.96006117
66LATS10.93001142
67BMPR20.87088374
68MAPK110.85092738
69MAPKAPK30.82839960
70TRPM70.82527835
71EPHA30.82067180
72BRAF0.80853722
73TAOK20.80659655
74PDGFRB0.78281851
75MYLK0.78076386
76PRKAA20.73922411
77CHUK0.71932207
78PIK3CA0.71275935
79PIM10.70903724
80ILK0.69642106
81PDK10.69189011
82MAP3K10.67713545
83PTK20.67450679
84MOS0.67145097
85NEK10.66918553
86MAP3K120.66523812
87MAPK120.64426718
88TESK20.62049364
89MATK0.61711567
90ADRBK20.60555597
91PAK40.60513342
92MAP2K10.59793149
93IRAK10.59700108
94FRK0.59188877
95FER0.59101579
96RAF10.59039832
97ABL10.58701399
98EGFR0.58261361
99PDGFRA0.58095672
100STK30.57976779
101PDK20.57228634
102GSK3A0.53864250
103FGFR30.53792641
104EIF2AK10.52753365
105MAP3K50.52275460
106MAPK40.51887007
107HCK0.51376427
108MST40.50802232
109IGF1R0.49091610
110LYN0.47860034
111TESK10.47201569
112BTK0.46784803
113TIE10.46295755
114AKT20.45923729
115PDPK10.45872599
116STK40.45398368
117PRKCD0.44559774
118SGK30.44469013
119DYRK1B0.43675743
120ERBB20.43231639
121MAP2K20.42185085
122EIF2AK20.42033763
123FGR0.41881324
124TEC0.41418066
125RET0.40990915
126MAP3K80.40926665
127MAP2K60.39397391
128PRKACG0.39222070
129DAPK30.37799685
130MAP3K130.37782595
131SYK0.37540447
132PAK20.37361169
133PRKG20.37094313
134RPS6KA60.36993100
135GRK60.36961481
136NUAK10.36345973
137PDK40.36233595
138PDK30.36233595
139CDC42BPA0.34405733
140MAPK70.34060078
141SCYL20.31974550
142PRKD10.31943957
143PTK2B0.30537459

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.63934099
2Complement and coagulation cascades_Homo sapiens_hsa046102.84440857
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76716410
4Staphylococcus aureus infection_Homo sapiens_hsa051502.75019284
5Nitrogen metabolism_Homo sapiens_hsa009102.74387096
6Fatty acid degradation_Homo sapiens_hsa000712.73675641
7Mineral absorption_Homo sapiens_hsa049782.70937198
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62750720
9PPAR signaling pathway_Homo sapiens_hsa033202.51030205
10Arginine biosynthesis_Homo sapiens_hsa002202.40747838
11Caffeine metabolism_Homo sapiens_hsa002322.37682315
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30420378
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30030242
14Fatty acid metabolism_Homo sapiens_hsa012122.27672957
15Tryptophan metabolism_Homo sapiens_hsa003802.23176595
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22804025
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16440503
18Propanoate metabolism_Homo sapiens_hsa006402.10520488
19Peroxisome_Homo sapiens_hsa041462.09535278
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80136599
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76844567
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70728801
23Chemical carcinogenesis_Homo sapiens_hsa052041.69187630
24beta-Alanine metabolism_Homo sapiens_hsa004101.67509161
25Histidine metabolism_Homo sapiens_hsa003401.66335747
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65013869
27Fatty acid elongation_Homo sapiens_hsa000621.55050786
28Retinol metabolism_Homo sapiens_hsa008301.50720741
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48645655
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.48331930
31Fatty acid biosynthesis_Homo sapiens_hsa000611.43637906
32Butanoate metabolism_Homo sapiens_hsa006501.41960477
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.33286768
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31866756
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30180521
36Carbon metabolism_Homo sapiens_hsa012001.29072904
37Phenylalanine metabolism_Homo sapiens_hsa003601.27137415
38Steroid biosynthesis_Homo sapiens_hsa001001.27023770
39Pyruvate metabolism_Homo sapiens_hsa006201.24675896
40Selenocompound metabolism_Homo sapiens_hsa004501.24499571
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22173488
42Fat digestion and absorption_Homo sapiens_hsa049751.19720625
43Starch and sucrose metabolism_Homo sapiens_hsa005001.18045892
44Lysosome_Homo sapiens_hsa041421.15350388
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15042389
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12019080
47Tyrosine metabolism_Homo sapiens_hsa003501.08133031
48ABC transporters_Homo sapiens_hsa020101.04402730
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.03383623
50Pentose phosphate pathway_Homo sapiens_hsa000300.99243075
51Folate biosynthesis_Homo sapiens_hsa007900.98778647
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97841133
53Bile secretion_Homo sapiens_hsa049760.95708524
54Biosynthesis of amino acids_Homo sapiens_hsa012300.95309406
55HIF-1 signaling pathway_Homo sapiens_hsa040660.95015765
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92126475
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88829714
58Glutathione metabolism_Homo sapiens_hsa004800.88741190
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88437863
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87056017
61Glycerolipid metabolism_Homo sapiens_hsa005610.86947942
62Sphingolipid metabolism_Homo sapiens_hsa006000.81097227
63Sulfur relay system_Homo sapiens_hsa041220.80882912
64Vitamin digestion and absorption_Homo sapiens_hsa049770.80854774
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79758462
66Sulfur metabolism_Homo sapiens_hsa009200.77840454
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76018188
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.74950118
69Arginine and proline metabolism_Homo sapiens_hsa003300.69964754
70Legionellosis_Homo sapiens_hsa051340.68301270
71Malaria_Homo sapiens_hsa051440.67946503
72Leishmaniasis_Homo sapiens_hsa051400.66970105
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.66626602
74Other glycan degradation_Homo sapiens_hsa005110.66306148
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65935980
76Galactose metabolism_Homo sapiens_hsa000520.65319774
77Arachidonic acid metabolism_Homo sapiens_hsa005900.61339029
78Vitamin B6 metabolism_Homo sapiens_hsa007500.60559063
79Pertussis_Homo sapiens_hsa051330.60007605
80One carbon pool by folate_Homo sapiens_hsa006700.53910738
81Phagosome_Homo sapiens_hsa041450.53476927
82Protein export_Homo sapiens_hsa030600.52097687
83Lysine degradation_Homo sapiens_hsa003100.51508956
84Circadian rhythm_Homo sapiens_hsa047100.46890306
85Proteasome_Homo sapiens_hsa030500.46594427
86Tuberculosis_Homo sapiens_hsa051520.46117633
87N-Glycan biosynthesis_Homo sapiens_hsa005100.44156620
88Vibrio cholerae infection_Homo sapiens_hsa051100.43957589
89Hematopoietic cell lineage_Homo sapiens_hsa046400.43921143
90ECM-receptor interaction_Homo sapiens_hsa045120.42659990
91Osteoclast differentiation_Homo sapiens_hsa043800.41696231
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39273769
93Insulin resistance_Homo sapiens_hsa049310.38770305
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38476246
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38172231
96Proteoglycans in cancer_Homo sapiens_hsa052050.38044792
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37435176
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34903232
99Metabolic pathways_Homo sapiens_hsa011000.34286591
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33865974
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.33111842
102Prion diseases_Homo sapiens_hsa050200.32573271
103Fructose and mannose metabolism_Homo sapiens_hsa000510.32066439
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28673104
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27851401
106Apoptosis_Homo sapiens_hsa042100.26592708
107Amoebiasis_Homo sapiens_hsa051460.25862865
108Toxoplasmosis_Homo sapiens_hsa051450.25262384
109Antigen processing and presentation_Homo sapiens_hsa046120.22834361
110Hepatitis C_Homo sapiens_hsa051600.22640994
111Rheumatoid arthritis_Homo sapiens_hsa053230.22301932
112Influenza A_Homo sapiens_hsa051640.20217892
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19428303
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.19139004
115TNF signaling pathway_Homo sapiens_hsa046680.18491607
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16766968
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16761831
118Renin-angiotensin system_Homo sapiens_hsa046140.16514331
119Measles_Homo sapiens_hsa051620.15068080
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.13398648
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12670715

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