PLIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.96276712
2Golgi transport vesicle coating (GO:0048200)4.93658867
3COPI coating of Golgi vesicle (GO:0048205)4.93658867
4skin morphogenesis (GO:0043589)4.55207476
5protein maturation by protein folding (GO:0022417)4.53166371
6positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.92885386
7protein retention in ER lumen (GO:0006621)3.85941003
8protein localization to endosome (GO:0036010)3.85687182
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.80383100
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.75202820
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.71757003
12extracellular fibril organization (GO:0043206)3.64925977
13bundle of His cell to Purkinje myocyte communication (GO:0086069)3.63629125
14type B pancreatic cell proliferation (GO:0044342)3.47427793
15fibril organization (GO:0097435)3.46783026
16adhesion of symbiont to host (GO:0044406)3.45229793
17adhesion of symbiont to host cell (GO:0044650)3.40620154
18virion attachment to host cell (GO:0019062)3.40620154
19endodermal cell differentiation (GO:0035987)3.33456342
20cell adhesion mediated by integrin (GO:0033627)3.30442116
21ribosomal small subunit biogenesis (GO:0042274)3.26440295
22lipopolysaccharide biosynthetic process (GO:0009103)3.09874693
23regulation of lipoprotein metabolic process (GO:0050746)3.09758579
24amyloid precursor protein metabolic process (GO:0042982)3.09726404
25stress fiber assembly (GO:0043149)3.07728122
26UV protection (GO:0009650)3.06998539
27regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.05636217
28ribosomal small subunit assembly (GO:0000028)3.05309035
29viral transcription (GO:0019083)3.02183177
30nuclear envelope reassembly (GO:0031468)3.01378603
31mitotic nuclear envelope reassembly (GO:0007084)3.01378603
32negative regulation of smooth muscle cell migration (GO:0014912)2.96772539
33positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.95086433
34hyaluronan catabolic process (GO:0030214)2.92511474
35negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89905924
36translational termination (GO:0006415)2.82695477
37sarcomere organization (GO:0045214)2.81277041
38glucose catabolic process (GO:0006007)2.78672456
39hypotonic response (GO:0006971)2.78586002
40negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.77348691
41peptidyl-proline hydroxylation (GO:0019511)2.76974487
42protein heterotrimerization (GO:0070208)2.76469434
43regulation of extracellular matrix disassembly (GO:0010715)2.75444741
44amyloid precursor protein catabolic process (GO:0042987)2.74050537
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73395236
46apoptotic cell clearance (GO:0043277)2.72135267
47lipopolysaccharide metabolic process (GO:0008653)2.70318418
48branched-chain amino acid catabolic process (GO:0009083)2.68890020
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.67561594
50protein hydroxylation (GO:0018126)2.67543123
51decidualization (GO:0046697)2.64812518
52actin filament depolymerization (GO:0030042)2.63103898
53endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62939079
54intestinal cholesterol absorption (GO:0030299)2.61062941
55regulation of gene silencing by RNA (GO:0060966)2.60993806
56regulation of posttranscriptional gene silencing (GO:0060147)2.60993806
57regulation of gene silencing by miRNA (GO:0060964)2.60993806
58fatty acid beta-oxidation (GO:0006635)2.58705848
59creatine metabolic process (GO:0006600)2.58206993
60GDP-mannose metabolic process (GO:0019673)2.57582465
61basement membrane organization (GO:0071711)2.56470788
62glycosphingolipid catabolic process (GO:0046479)2.54321712
63low-density lipoprotein particle clearance (GO:0034383)2.53524458
64regulation of early endosome to late endosome transport (GO:2000641)2.53198409
65regulation of integrin-mediated signaling pathway (GO:2001044)2.49875225
66regulation of superoxide anion generation (GO:0032928)2.49550738
67translational elongation (GO:0006414)2.46874822
68negative regulation of nitric-oxide synthase activity (GO:0051001)2.46837606
69protein targeting to ER (GO:0045047)2.46507700
70cell-substrate junction assembly (GO:0007044)2.46261843
71regulation of triglyceride catabolic process (GO:0010896)2.46235023
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45817294
73regulation of sequestering of triglyceride (GO:0010889)2.45735422
74collagen fibril organization (GO:0030199)2.44766032
75muscle cell migration (GO:0014812)2.44570213
76AMP metabolic process (GO:0046033)2.44450061
77platelet aggregation (GO:0070527)2.44403177
78negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43802502
79substrate-dependent cell migration (GO:0006929)2.43144535
80proline biosynthetic process (GO:0006561)2.42263472
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.42195418
82apoptotic process involved in morphogenesis (GO:0060561)2.41594492
83positive regulation of extracellular matrix organization (GO:1903055)2.41309813
84cellular response to vitamin (GO:0071295)2.41184901
85collagen metabolic process (GO:0032963)2.40948579
86positive regulation of endothelial cell apoptotic process (GO:2000353)2.40894256
87cotranslational protein targeting to membrane (GO:0006613)2.40421766
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39506871
89response to progesterone (GO:0032570)2.38941374
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37621781
91wound healing, spreading of epidermal cells (GO:0035313)2.36565447
92protein localization to endoplasmic reticulum (GO:0070972)2.34401321
93positive regulation of triglyceride lipase activity (GO:0061365)2.34142393
94positive regulation of lipoprotein lipase activity (GO:0051006)2.34142393
95ethanol metabolic process (GO:0006067)2.33243591
96negative regulation of protein localization to plasma membrane (GO:1903077)2.32551351
97viral life cycle (GO:0019058)2.32027318
98membrane raft organization (GO:0031579)2.30724708
99chondrocyte proliferation (GO:0035988)2.30576161
100cyclooxygenase pathway (GO:0019371)2.30332320
101intestinal absorption (GO:0050892)2.30185776
102myelin maintenance (GO:0043217)2.30086932
103pinocytosis (GO:0006907)2.29912514
104gap junction assembly (GO:0016264)2.29839745
105cellular response to vitamin D (GO:0071305)2.29573507
106oxidative phosphorylation (GO:0006119)2.28822942
107glycolipid catabolic process (GO:0019377)2.28721005
108primary alcohol catabolic process (GO:0034310)2.28177374
109mature B cell differentiation involved in immune response (GO:0002313)2.28039107
110positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.28001925
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27937163
112pyrimidine nucleoside salvage (GO:0043097)2.27005137
113pyrimidine-containing compound salvage (GO:0008655)2.27005137
114nucleotide-sugar biosynthetic process (GO:0009226)2.25843175
115positive regulation of actin filament depolymerization (GO:0030836)2.25540672
116wound healing, spreading of cells (GO:0044319)2.25170919
117membrane protein ectodomain proteolysis (GO:0006509)2.23851307
118multicellular organismal macromolecule metabolic process (GO:0044259)2.23821747
119fatty acid catabolic process (GO:0009062)2.23580630
120collagen catabolic process (GO:0030574)2.23229904
121regulation of cholesterol metabolic process (GO:0090181)2.23149567
122carnitine metabolic process (GO:0009437)2.23037308
123cortical actin cytoskeleton organization (GO:0030866)2.22022186
124branched-chain amino acid metabolic process (GO:0009081)2.21574608
125establishment of viral latency (GO:0019043)2.20459506
126regulation of metalloenzyme activity (GO:0048552)2.19961917
127NIK/NF-kappaB signaling (GO:0038061)2.19826450
128fatty acid oxidation (GO:0019395)2.19745852
129regulation of cholesterol storage (GO:0010885)2.19266892
130glial cell migration (GO:0008347)2.19241984
131negative regulation of fatty acid biosynthetic process (GO:0045717)2.17974185
132mesodermal cell differentiation (GO:0048333)2.17162745
133cellular copper ion homeostasis (GO:0006878)2.17133464
134regulation of monocyte chemotaxis (GO:0090025)2.16586120
135embryo implantation (GO:0007566)2.16110073
136multicellular organismal catabolic process (GO:0044243)2.15919122
137positive regulation of Rho protein signal transduction (GO:0035025)2.15527094
138lipid oxidation (GO:0034440)2.15475213
139maturation of SSU-rRNA (GO:0030490)2.15012959
140actin-myosin filament sliding (GO:0033275)2.14669563
141muscle filament sliding (GO:0030049)2.14669563
142translational initiation (GO:0006413)2.13348808
143biotin metabolic process (GO:0006768)2.13191737
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.12684386
145desmosome organization (GO:0002934)2.12262162
146ribosomal large subunit biogenesis (GO:0042273)2.12021111
147anterior/posterior axis specification, embryo (GO:0008595)2.11320468
148cholesterol homeostasis (GO:0042632)2.10754487
149heart contraction (GO:0060047)2.10342945
150heart process (GO:0003015)2.10342945
151positive regulation of lipid storage (GO:0010884)2.09359204
152glutathione derivative metabolic process (GO:1901685)2.08969695
153glutathione derivative biosynthetic process (GO:1901687)2.08969695
154epithelial cell-cell adhesion (GO:0090136)2.08485648
155NADPH regeneration (GO:0006740)2.08395361
156pentose-phosphate shunt (GO:0006098)2.07230931
157central nervous system myelination (GO:0022010)2.06591094
158axon ensheathment in central nervous system (GO:0032291)2.06591094
159response to folic acid (GO:0051593)2.06254773
160glomerular basement membrane development (GO:0032836)2.06106178
161pentose metabolic process (GO:0019321)2.05927247
162regulation of cardioblast differentiation (GO:0051890)2.05618150
163triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.05166545
164sterol homeostasis (GO:0055092)2.04797538
165L-serine metabolic process (GO:0006563)2.04474795
166amino sugar catabolic process (GO:0046348)2.04197056
167phagocytosis, recognition (GO:0006910)2.02487412
168hemidesmosome assembly (GO:0031581)2.01768288
169glycine metabolic process (GO:0006544)2.01488541
170regulation of skeletal muscle contraction (GO:0014819)2.00563514
171ethanol oxidation (GO:0006069)1.99857660
172regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.99550066
173cholesterol biosynthetic process (GO:0006695)1.97414525
174heme transport (GO:0015886)1.97109842
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)1.96944288
176hydrogen peroxide catabolic process (GO:0042744)1.96634514
177hepatocyte apoptotic process (GO:0097284)1.96533219
178ventricular cardiac muscle tissue morphogenesis (GO:0055010)1.95172159
179cardiac muscle tissue morphogenesis (GO:0055008)1.94756625
180angiotensin maturation (GO:0002003)1.94714548
181amino-acid betaine metabolic process (GO:0006577)1.94326159
182L-methionine salvage (GO:0071267)1.93741894
183L-methionine biosynthetic process (GO:0071265)1.93741894
184amino acid salvage (GO:0043102)1.93741894
185regulation of pseudopodium assembly (GO:0031272)1.92027886
186positive regulation of pseudopodium assembly (GO:0031274)1.91820987
187phospholipid homeostasis (GO:0055091)1.90885556
188serine family amino acid biosynthetic process (GO:0009070)1.89434881
189sulfur amino acid catabolic process (GO:0000098)1.89044693
190cellular protein complex disassembly (GO:0043624)1.88963678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.11667277
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.65191058
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63610898
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40656294
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19322852
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13823936
7LXR_22292898_ChIP-Seq_THP-1_Human2.03630508
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01176443
9MYC_18555785_ChIP-Seq_MESCs_Mouse1.97767596
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92005539
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84176770
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84176770
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84176770
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82815060
15E2F7_22180533_ChIP-Seq_HELA_Human1.80075492
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79970999
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.78804857
18STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76419047
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74899362
20TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73683172
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70768041
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67596517
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66615769
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65620412
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62387201
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61770687
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58327183
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53582354
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52387891
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51694418
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51540143
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51264510
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.51148055
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50792123
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49532846
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49083060
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47992418
38CLOCK_20551151_ChIP-Seq_293T_Human1.47334873
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43672270
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43397430
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42834642
42VDR_24763502_ChIP-Seq_THP-1_Human1.42517464
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42463066
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40744988
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40415964
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.40344178
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40318706
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.39603402
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39054252
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38847739
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38086281
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36610703
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36103472
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35328817
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35196629
56SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32953766
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32769234
58* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31822588
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31520831
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.30005634
61TP53_22127205_ChIP-Seq_IMR90_Human1.29921637
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.28383220
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28353187
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27960288
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.26427299
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26062503
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25996355
68NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24005775
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23070005
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22909597
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22909597
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22907097
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22279922
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21623975
75AR_21909140_ChIP-Seq_LNCAP_Human1.21468567
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.20135240
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.19889400
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.19263232
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18461325
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18301227
81ZNF263_19887448_ChIP-Seq_K562_Human1.18084151
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17717519
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17672444
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16882181
85GATA4_25053715_ChIP-Seq_YYC3_Human1.16455646
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16274633
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15963423
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15865105
89MYC_22102868_ChIP-Seq_BL_Human1.15588338
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.15169163
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15017228
92* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14521466
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14240550
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13598952
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13106760
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12457472
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.12138238
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11448793
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10829967
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10823735
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10788631
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10638477
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.10295592
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10267437
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.09869993
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09082264
107TFEB_21752829_ChIP-Seq_HELA_Human1.08755224
108* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08221206
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08184727
110* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08037041
111* ATF3_27146783_Chip-Seq_COLON_Human1.07966342
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.07886306
113OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07643635
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07113354
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07083556
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.07039887
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07000647
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.06407806
119* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06167630
120SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06052440
121ELF1_20517297_ChIP-Seq_JURKAT_Human1.06006540
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05857622
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05176833
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03963410
125* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03741380
126VDR_21846776_ChIP-Seq_THP-1_Human1.03234537
127GATA6_25053715_ChIP-Seq_YYC3_Human1.02441990
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02358988
129BCL6_27268052_Chip-Seq_Bcells_Human1.02229776
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01727973
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01270233
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99662255
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99067860
134NCOR1_26117541_ChIP-Seq_K562_Human0.98740297
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97546008
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97166185
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97139442
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97125399
139NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95987105
140* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95132871
141ELK1_22589737_ChIP-Seq_MCF10A_Human0.94785038
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.94686779
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94418535
144SPI1_23547873_ChIP-Seq_NB4_Human0.93786416
145XRN2_22483619_ChIP-Seq_HELA_Human0.93462223
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93405085
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93026218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.45459043
2MP0008438_abnormal_cutaneous_collagen2.72542425
3MP0003806_abnormal_nucleotide_metabolis2.70642494
4MP0005257_abnormal_intraocular_pressure2.66587668
5MP0003950_abnormal_plasma_membrane2.46237136
6MP0001542_abnormal_bone_strength2.29798236
7MP0002877_abnormal_melanocyte_morpholog2.07671324
8MP0005058_abnormal_lysosome_morphology2.02645273
9MP0004084_abnormal_cardiac_muscle1.87157098
10MP0003186_abnormal_redox_activity1.77742145
11MP0003566_abnormal_cell_adhesion1.77301866
12MP0005360_urolithiasis1.73387279
13MP0003191_abnormal_cellular_cholesterol1.72600028
14MP0003091_abnormal_cell_migration1.64140107
15MP0003705_abnormal_hypodermis_morpholog1.63098401
16MP0005275_abnormal_skin_tensile1.62455419
17MP0005464_abnormal_platelet_physiology1.62259586
18MP0004858_abnormal_nervous_system1.61326043
19MP0003136_yellow_coat_color1.58214042
20MP0010030_abnormal_orbit_morphology1.55262846
21MP0004381_abnormal_hair_follicle1.53541118
22MP0001666_abnormal_nutrient_absorption1.48421116
23MP0001533_abnormal_skeleton_physiology1.43839147
24MP0003453_abnormal_keratinocyte_physiol1.43619200
25MP0005023_abnormal_wound_healing1.43429094
26MP0005330_cardiomyopathy1.42163493
27MP0005408_hypopigmentation1.40845713
28MP0009384_cardiac_valve_regurgitation1.38433185
29MP0003075_altered_response_to1.36492877
30MP0001243_abnormal_dermal_layer1.36167205
31MP0002796_impaired_skin_barrier1.35457868
32MP0005451_abnormal_body_composition1.34461554
33MP0003828_pulmonary_edema1.32649743
34MP0003300_gastrointestinal_ulcer1.32226031
35MP0005503_abnormal_tendon_morphology1.31073352
36MP0000767_abnormal_smooth_muscle1.30618923
37MP0010368_abnormal_lymphatic_system1.28209178
38MP0000749_muscle_degeneration1.28007922
39MP0005670_abnormal_white_adipose1.27757909
40MP0001853_heart_inflammation1.27073070
41MP0000343_altered_response_to1.26791850
42MP0009278_abnormal_bone_marrow1.25569947
43MP0000013_abnormal_adipose_tissue1.25408350
44MP0005666_abnormal_adipose_tissue1.25115717
45MP0003646_muscle_fatigue1.23503158
46MP0002837_dystrophic_cardiac_calcinosis1.23176284
47MP0005623_abnormal_meninges_morphology1.21394380
48MP0000750_abnormal_muscle_regeneration1.21146795
49MP0004233_abnormal_muscle_weight1.20082413
50MP0005390_skeleton_phenotype1.19531174
51MP0006054_spinal_hemorrhage1.18717896
52MP0010352_gastrointestinal_tract_polyps1.17664035
53MP0002060_abnormal_skin_morphology1.17237951
54MP0004510_myositis1.15263926
55MP0002896_abnormal_bone_mineralization1.12662095
56MP0003567_abnormal_fetal_cardiomyocyte1.11948368
57MP0004947_skin_inflammation1.11255567
58MP0005508_abnormal_skeleton_morphology1.10960769
59MP0004185_abnormal_adipocyte_glucose1.10750959
60MP0002998_abnormal_bone_remodeling1.10681200
61MP0004036_abnormal_muscle_relaxation1.10159553
62MP0004272_abnormal_basement_membrane1.09790653
63MP0003941_abnormal_skin_development1.09404166
64MP0003279_aneurysm1.08360637
65MP0005164_abnormal_response_to1.08248904
66MP0003718_maternal_effect1.07700063
67MP0003172_abnormal_lysosome_physiology1.06482590
68MP0005501_abnormal_skin_physiology1.03869167
69MP0010630_abnormal_cardiac_muscle1.02264837
70MP0001544_abnormal_cardiovascular_syste1.01740812
71MP0005385_cardiovascular_system_phenoty1.01740812
72MP0000490_abnormal_crypts_of1.00170876
73MP0002139_abnormal_hepatobiliary_system0.99494648
74MP0004019_abnormal_vitamin_homeostasis0.98888888
75MP0005165_increased_susceptibility_to0.98195364
76MP0006138_congestive_heart_failure0.97772989
77MP0002254_reproductive_system_inflammat0.96783596
78MP0004087_abnormal_muscle_fiber0.95053345
79MP0001881_abnormal_mammary_gland0.93787692
80MP0000685_abnormal_immune_system0.93359324
81MP0001958_emphysema0.92977572
82MP0009643_abnormal_urine_homeostasis0.92068204
83MP0010329_abnormal_lipoprotein_level0.91505227
84MP0000372_irregular_coat_pigmentation0.91490043
85MP0009379_abnormal_foot_pigmentation0.90647554
86MP0000003_abnormal_adipose_tissue0.88419738
87MP0003795_abnormal_bone_structure0.88348069
88MP0005595_abnormal_vascular_smooth0.87569232
89MP0010155_abnormal_intestine_physiology0.87419321
90MP0009053_abnormal_anal_canal0.87144532
91MP0005332_abnormal_amino_acid0.86747169
92MP0001545_abnormal_hematopoietic_system0.86664155
93MP0005397_hematopoietic_system_phenotyp0.86664155
94MP0003878_abnormal_ear_physiology0.85470498
95MP0005377_hearing/vestibular/ear_phenot0.85470498
96MP0005085_abnormal_gallbladder_physiolo0.85317538
97MP0003448_altered_tumor_morphology0.85209780
98MP0000759_abnormal_skeletal_muscle0.85197982
99MP0002098_abnormal_vibrissa_morphology0.85065825
100MP0002148_abnormal_hypersensitivity_rea0.84273939
101MP0000604_amyloidosis0.83333438
102MP0008875_abnormal_xenobiotic_pharmacok0.80600744
103MP0004264_abnormal_extraembryonic_tissu0.80586230
104MP0005171_absent_coat_pigmentation0.80063655
105MP0009785_altered_susceptibility_to0.80007404
106MP0002972_abnormal_cardiac_muscle0.79346869
107MP0000858_altered_metastatic_potential0.78626994
108MP0006082_CNS_inflammation0.78320849
109MP0008469_abnormal_protein_level0.77911660
110MP0004957_abnormal_blastocyst_morpholog0.77905244
111MP0005375_adipose_tissue_phenotype0.77893278
112MP0002295_abnormal_pulmonary_circulatio0.77178379
113MP0003656_abnormal_erythrocyte_physiolo0.76804824
114MP0008775_abnormal_heart_ventricle0.76265446
115MP0005319_abnormal_enzyme/_coenzyme0.76217876
116MP0003011_delayed_dark_adaptation0.76056854
117MP0009780_abnormal_chondrocyte_physiolo0.76028304
118MP0000762_abnormal_tongue_morphology0.75962545
119MP0005166_decreased_susceptibility_to0.75780743
120MP0002419_abnormal_innate_immunity0.75716455
121MP0001835_abnormal_antigen_presentation0.75570115
122MP0000751_myopathy0.74553298
123MP0003303_peritoneal_inflammation0.74496407
124MP0002132_abnormal_respiratory_system0.74387363
125MP0003195_calcinosis0.74376679
126MP0001216_abnormal_epidermal_layer0.73278145
127MP0002118_abnormal_lipid_homeostasis0.72329708
128MP0000747_muscle_weakness0.72104855
129MP0002933_joint_inflammation0.72009138
130MP0005197_abnormal_uvea_morphology0.71671656
131MP0010234_abnormal_vibrissa_follicle0.71530762
132MP0000358_abnormal_cell_content/0.71451751
133MP0006036_abnormal_mitochondrial_physio0.71252532
134MP0008260_abnormal_autophagy0.71193176
135MP0000733_abnormal_muscle_development0.71187539
136MP0003436_decreased_susceptibility_to0.70977000
137MP0005083_abnormal_biliary_tract0.70357704
138MP0003693_abnormal_embryo_hatching0.70356055
139MP0000377_abnormal_hair_follicle0.69968375
140MP0005075_abnormal_melanosome_morpholog0.69406266
141MP0003329_amyloid_beta_deposits0.69138954
142MP0010678_abnormal_skin_adnexa0.68875237
143MP0000609_abnormal_liver_physiology0.68767280
144MP0005025_abnormal_response_to0.68723459
145MP0001849_ear_inflammation0.68274851
146MP0000249_abnormal_blood_vessel0.67352851
147MP0005621_abnormal_cell_physiology0.67008927
148MP0005000_abnormal_immune_tolerance0.66824563
149MP0009333_abnormal_splenocyte_physiolog0.66637255
150MP0004782_abnormal_surfactant_physiolog0.66394809
151MP0000467_abnormal_esophagus_morphology0.66004761

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.06421135
2Ventricular tachycardia (HP:0004756)3.88838808
3Spinal rigidity (HP:0003306)3.52040959
4Type 1 muscle fiber predominance (HP:0003803)3.43118597
5Abnormality of glycolipid metabolism (HP:0010969)3.25595209
6Abnormality of liposaccharide metabolism (HP:0010968)3.25595209
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.25595209
8Follicular hyperkeratosis (HP:0007502)3.25448946
9Muscle fiber splitting (HP:0003555)3.18296519
10Aortic dissection (HP:0002647)3.16299571
11Hyperglycinuria (HP:0003108)3.10266511
12Achilles tendon contracture (HP:0001771)2.93399203
13Short nail (HP:0001799)2.91089475
14Slender build (HP:0001533)2.87139837
15Premature rupture of membranes (HP:0001788)2.86835180
16Lipoatrophy (HP:0100578)2.82719976
17Distal lower limb amyotrophy (HP:0008944)2.80796421
18Abnormality of dentin (HP:0010299)2.78794438
19Ileus (HP:0002595)2.75047525
20Abnormality of glycine metabolism (HP:0010895)2.74622022
21Abnormality of serine family amino acid metabolism (HP:0010894)2.74622022
22Vacuolated lymphocytes (HP:0001922)2.73565383
23Mildly elevated creatine phosphokinase (HP:0008180)2.72248006
24Aortic aneurysm (HP:0004942)2.72112701
25Axonal loss (HP:0003447)2.71167855
26Xanthomatosis (HP:0000991)2.69819185
27Nausea (HP:0002018)2.68185582
28Exercise-induced muscle cramps (HP:0003710)2.66533926
29Increased variability in muscle fiber diameter (HP:0003557)2.65275449
30Bladder diverticulum (HP:0000015)2.63629145
31Spondylolisthesis (HP:0003302)2.63095404
32Abnormality of skeletal muscle fiber size (HP:0012084)2.62052160
33Soft skin (HP:0000977)2.61305203
34Dicarboxylic aciduria (HP:0003215)2.61038295
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61038295
36Wormian bones (HP:0002645)2.60767621
37Abnormality of the Achilles tendon (HP:0005109)2.60378528
38Elbow flexion contracture (HP:0002987)2.59319862
39Blue sclerae (HP:0000592)2.58596687
40Vascular tortuosity (HP:0004948)2.56090610
41Abnormality of fatty-acid metabolism (HP:0004359)2.55521215
42Sudden death (HP:0001699)2.53333112
43Joint stiffness (HP:0001387)2.52932942
44Dilated cardiomyopathy (HP:0001644)2.51489662
45Increased connective tissue (HP:0009025)2.51479671
46Peritonitis (HP:0002586)2.49022997
47Rhabdomyolysis (HP:0003201)2.48718640
48Multiple enchondromatosis (HP:0005701)2.46835329
49Upper limb amyotrophy (HP:0009129)2.46638578
50Distal upper limb amyotrophy (HP:0007149)2.46638578
51Dysostosis multiplex (HP:0000943)2.46352608
52Genu recurvatum (HP:0002816)2.43967787
53Rough bone trabeculation (HP:0100670)2.43463640
54Entropion (HP:0000621)2.43430559
55Prolonged neonatal jaundice (HP:0006579)2.42305825
56Dilatation of the ascending aorta (HP:0005111)2.41890333
57Abnormality of macrophages (HP:0004311)2.37895092
58Reticulocytopenia (HP:0001896)2.33833603
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.30986951
60Mesangial abnormality (HP:0001966)2.29676261
61Distal lower limb muscle weakness (HP:0009053)2.28787606
62Hepatic necrosis (HP:0002605)2.28430499
63Arterial tortuosity (HP:0005116)2.27840388
64Reduced subcutaneous adipose tissue (HP:0003758)2.24832902
65Hyperammonemia (HP:0001987)2.21997303
66Natal tooth (HP:0000695)2.20089455
67Myoglobinuria (HP:0002913)2.18739046
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.18280933
69Osteolytic defects of the hand bones (HP:0009699)2.18280933
70Abnormal hemoglobin (HP:0011902)2.14711812
71Hyporeflexia of lower limbs (HP:0002600)2.14529036
72Biconcave vertebral bodies (HP:0004586)2.13883929
73Pustule (HP:0200039)2.13732157
74Hepatosplenomegaly (HP:0001433)2.09662916
75Difficulty climbing stairs (HP:0003551)2.09156742
76Hypoglycemic coma (HP:0001325)2.08799202
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07549381
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07549381
79Abnormality of polysaccharide metabolism (HP:0011012)2.07549381
80Abnormality of the acetabulum (HP:0003170)2.07404519
81Neonatal short-limb short stature (HP:0008921)2.06746085
82Amyloidosis (HP:0011034)2.04472033
83Mitral regurgitation (HP:0001653)2.01413514
84Mucopolysacchariduria (HP:0008155)1.99989185
85Urinary glycosaminoglycan excretion (HP:0003541)1.99989185
86Cardiovascular calcification (HP:0011915)1.99955470
87Abnormal cartilage morphology (HP:0002763)1.99757066
88Abnormal delivery (HP:0001787)1.98340170
89Round ear (HP:0100830)1.97792003
90Macrocytic anemia (HP:0001972)1.96799658
91Myocardial infarction (HP:0001658)1.96245418
92Abnormality of the distal phalanges of the toes (HP:0010182)1.95962641
93Asymmetric septal hypertrophy (HP:0001670)1.93735518
94Cellulitis (HP:0100658)1.92371204
95Abnormality of the umbilical cord (HP:0010881)1.91520299
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91416349
97Joint laxity (HP:0001388)1.91357815
98Limb-girdle muscle atrophy (HP:0003797)1.90814029
99Palpitations (HP:0001962)1.90080456
100Eczematoid dermatitis (HP:0000976)1.88043264
101Nemaline bodies (HP:0003798)1.87129425
102Hand muscle atrophy (HP:0009130)1.86548552
103Ovoid vertebral bodies (HP:0003300)1.84766380
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84758402
105Abnormal trabecular bone morphology (HP:0100671)1.83804701
106Hyperlipoproteinemia (HP:0010980)1.83335664
107Ulnar deviation of the wrist (HP:0003049)1.82835403
108Breast hypoplasia (HP:0003187)1.82351830
109Esophageal varix (HP:0002040)1.82347404
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82020108
111Loss of speech (HP:0002371)1.81319487
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80778917
113Mitral stenosis (HP:0001718)1.79483971
114Cerebral aneurysm (HP:0004944)1.79384993
115Generalized aminoaciduria (HP:0002909)1.78067288
116Thin bony cortex (HP:0002753)1.77722889
117Hepatocellular necrosis (HP:0001404)1.77079552
118Abnormality of proline metabolism (HP:0010907)1.76091835
119Hydroxyprolinuria (HP:0003080)1.76091835
120Lower limb amyotrophy (HP:0007210)1.75967874
121Proximal tubulopathy (HP:0000114)1.75903926
122Hyperacusis (HP:0010780)1.74581323
123Shallow orbits (HP:0000586)1.74295422
124Ulnar bowing (HP:0003031)1.74089709
125Trismus (HP:0000211)1.73502256
126Hypertensive crisis (HP:0100735)1.72829631
127Generalized amyotrophy (HP:0003700)1.72046009
128Ureteral duplication (HP:0000073)1.71959080
129Segmental peripheral demyelination/remyelination (HP:0003481)1.71918059
130Recurrent abscess formation (HP:0002722)1.71616549
131Glucose intolerance (HP:0000833)1.70957025
132Muscle fiber inclusion bodies (HP:0100299)1.70301391
133Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70116519
134Hyperglycinemia (HP:0002154)1.69916525
135Coxa vara (HP:0002812)1.69449599
136EMG: myopathic abnormalities (HP:0003458)1.69271872
137Abnormal gallbladder physiology (HP:0012438)1.68507496
138Cholecystitis (HP:0001082)1.68507496
139Calf muscle hypertrophy (HP:0008981)1.68409981
140Ankle contracture (HP:0006466)1.67987117
141Aortic regurgitation (HP:0001659)1.67665326
142Protrusio acetabuli (HP:0003179)1.67633611
143Lethargy (HP:0001254)1.67272292
144Diaphragmatic weakness (HP:0009113)1.66915159
145Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66583630
146Atrophic scars (HP:0001075)1.66398872
147Duplicated collecting system (HP:0000081)1.65380349
148Abnormality of the salivary glands (HP:0010286)1.64538143
149Abnormality of skull ossification (HP:0002703)1.64203015
150Abnormality of carpal bone ossification (HP:0006257)1.64059132
151Abnormality of cells of the erythroid lineage (HP:0012130)1.63126581
152Congenital ichthyosiform erythroderma (HP:0007431)1.62983515
153Pterygium (HP:0001059)1.62435995
154Palmoplantar keratoderma (HP:0000982)1.62185286
155Abnormality of urine glucose concentration (HP:0011016)1.61941307
156Glycosuria (HP:0003076)1.61941307
157Breech presentation (HP:0001623)1.61303839
158Congenital, generalized hypertrichosis (HP:0004540)1.61216136
159Nonimmune hydrops fetalis (HP:0001790)1.60673167
160Muscle hypertrophy of the lower extremities (HP:0008968)1.60319378
161Alopecia of scalp (HP:0002293)1.59362627
162Stridor (HP:0010307)1.58888932
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58582331
164Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56819252
165Intrahepatic cholestasis (HP:0001406)1.55581678
166Subaortic stenosis (HP:0001682)1.55361222
167Abnormality of the left ventricular outflow tract (HP:0011103)1.55361222
168Increased muscle lipid content (HP:0009058)1.55170734
169Respiratory failure (HP:0002878)1.54716934
170Progressive muscle weakness (HP:0003323)1.53430197
171Fragile skin (HP:0001030)1.52986155
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.52413937
173Petechiae (HP:0000967)1.52015783
174Vertebral compression fractures (HP:0002953)1.51512206
175Increased serum ferritin (HP:0003281)1.51083143
176Atrial fibrillation (HP:0005110)1.49779721
177Cervical subluxation (HP:0003308)1.47651129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK2.91607144
2LIMK12.84758413
3EPHA22.74087045
4EPHB12.67030834
5TTN2.66743761
6NME22.46070582
7PBK2.25851193
8TAOK22.21838597
9VRK22.10127678
10BUB12.07896736
11MST42.04852502
12ARAF2.04059311
13MOS1.99695802
14PRPF4B1.85601795
15PTK21.85380045
16MST1R1.71215251
17MAP2K21.69529369
18TESK21.66782679
19MYLK1.63099653
20IRAK31.58793229
21MET1.58217837
22STK101.56729296
23TRIB31.56367078
24WEE11.56311161
25SMG11.54767598
26MAPKAPK51.52928526
27PDGFRA1.50993238
28LRRK21.48790234
29RPS6KB21.35175233
30TLK11.31155393
31SIK11.30413178
32PIM21.27384857
33STK41.25965368
34BLK1.25711952
35LMTK21.24726737
36ZAK1.21775746
37PKN21.15852809
38PAK41.15789328
39TRPM71.15183210
40KDR1.14717016
41FLT31.14203196
42MAP3K31.12659856
43MAP2K31.12256325
44SCYL21.07226269
45IRAK41.06828434
46PDK21.05418514
47PAK21.05361220
48OBSCN1.05344073
49ICK1.03826089
50PIM11.03739558
51ILK0.98581266
52TYK20.98424280
53ERBB40.98336494
54ZAP700.97530080
55PRKG20.96787364
56ERN10.95829065
57TBK10.92701168
58MAP3K80.92243994
59NEK90.91907077
60TAOK30.91651052
61EIF2AK10.90356542
62TTK0.88867411
63TGFBR20.87897482
64PTK60.87561832
65NEK10.85144494
66NLK0.84535450
67CLK10.82969550
68IKBKB0.81137106
69TIE10.80467044
70DDR20.78971243
71PRKD10.77834680
72BMX0.77684044
73PIK3CG0.77059914
74CDC42BPA0.76888295
75NTRK10.75494111
76PIK3CA0.75415500
77JAK30.75054496
78MAPKAPK30.74647756
79MAP3K110.74456357
80MAPKAPK20.74347840
81STK390.73829043
82RPS6KA50.72826592
83STK38L0.72339863
84FGFR40.69008569
85GRK60.68708830
86MUSK0.68675102
87CDK70.64615341
88KIT0.63495561
89BRAF0.62811786
90PAK10.62765381
91ROCK20.62525426
92MAP3K140.61830545
93PRKD20.61530473
94DAPK30.61095250
95RPS6KA60.60964979
96ABL20.60909529
97MAP3K10.60472997
98PTK2B0.60185774
99MAP3K120.60026759
100MAP3K60.59534659
101EPHA30.59140916
102AURKA0.58450296
103PDK30.57406730
104PDK40.57406730
105CSK0.57295214
106RPS6KC10.57161827
107RPS6KL10.57161827
108PKN10.57159103
109AURKB0.56521225
110MAP4K10.55589475
111CDK80.55334629
112LATS20.54708883
113BTK0.53736644
114GSK3A0.52747172
115EIF2AK30.51453174
116CSF1R0.50986014
117DYRK1B0.49851406
118TESK10.49227882
119RIPK10.48883601
120TAOK10.47563356
121DAPK10.47441869
122CAMK2D0.47341441
123DMPK0.46098720
124STK30.45745819
125TSSK60.45698725
126ROCK10.45406434
127NEK20.45353643
128STK240.45176416
129GRK70.45096524
130MKNK10.43403098
131MAP3K100.43100102
132RPS6KA40.42984187
133EPHB20.42896729
134LATS10.41819642
135MATK0.41056778
136RPS6KA20.38508036
137CAMK2G0.38120397
138ADRBK10.37783288
139MTOR0.37027719
140MAP3K130.36983576
141STK380.35360528
142AKT20.32301485
143MAPK110.32181842
144PDPK10.30762148
145MAP3K50.29885588
146STK160.27514025

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.21307938
2Ribosome_Homo sapiens_hsa030102.21698383
3Fatty acid elongation_Homo sapiens_hsa000622.16533883
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09116174
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.08341213
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07504086
7Fatty acid degradation_Homo sapiens_hsa000711.96738776
8Fat digestion and absorption_Homo sapiens_hsa049751.95167035
9Folate biosynthesis_Homo sapiens_hsa007901.92720209
10Shigellosis_Homo sapiens_hsa051311.79910797
11Bladder cancer_Homo sapiens_hsa052191.79407684
12Propanoate metabolism_Homo sapiens_hsa006401.74942137
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72165505
14Steroid biosynthesis_Homo sapiens_hsa001001.69986330
15Glutathione metabolism_Homo sapiens_hsa004801.67372664
16Histidine metabolism_Homo sapiens_hsa003401.64083404
17Focal adhesion_Homo sapiens_hsa045101.63276082
18Vitamin digestion and absorption_Homo sapiens_hsa049771.61376414
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53918245
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52417359
21Carbon metabolism_Homo sapiens_hsa012001.51880887
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51297787
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49871454
24Fatty acid metabolism_Homo sapiens_hsa012121.44421689
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41714829
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38986216
27N-Glycan biosynthesis_Homo sapiens_hsa005101.35223677
28Amoebiasis_Homo sapiens_hsa051461.33736809
29Arginine and proline metabolism_Homo sapiens_hsa003301.32102340
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31959319
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31606356
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28848320
33Proteasome_Homo sapiens_hsa030501.28168826
34Caffeine metabolism_Homo sapiens_hsa002321.27208771
35Proteoglycans in cancer_Homo sapiens_hsa052051.25068786
36PPAR signaling pathway_Homo sapiens_hsa033201.24821223
37Salmonella infection_Homo sapiens_hsa051321.23855817
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.22161606
39Vibrio cholerae infection_Homo sapiens_hsa051101.21758315
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21642755
41Other glycan degradation_Homo sapiens_hsa005111.21305469
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19569894
43Viral myocarditis_Homo sapiens_hsa054161.18884657
44Galactose metabolism_Homo sapiens_hsa000521.18844524
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17166842
46Biosynthesis of amino acids_Homo sapiens_hsa012301.16554273
47Sulfur metabolism_Homo sapiens_hsa009201.15449110
48Phagosome_Homo sapiens_hsa041451.14278289
49beta-Alanine metabolism_Homo sapiens_hsa004101.13110000
50Pentose phosphate pathway_Homo sapiens_hsa000301.13088851
51Pertussis_Homo sapiens_hsa051331.11976540
52Malaria_Homo sapiens_hsa051441.10158487
53DNA replication_Homo sapiens_hsa030301.08773475
54Starch and sucrose metabolism_Homo sapiens_hsa005001.08260914
55Peroxisome_Homo sapiens_hsa041461.08219007
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08014457
57Arachidonic acid metabolism_Homo sapiens_hsa005901.06358912
58Apoptosis_Homo sapiens_hsa042101.06304857
59Chemical carcinogenesis_Homo sapiens_hsa052041.04975348
60Fructose and mannose metabolism_Homo sapiens_hsa000511.04811210
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02832537
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02121910
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02043563
64Leishmaniasis_Homo sapiens_hsa051401.01743574
65One carbon pool by folate_Homo sapiens_hsa006701.00803067
66Tryptophan metabolism_Homo sapiens_hsa003800.97529023
67Linoleic acid metabolism_Homo sapiens_hsa005910.97069548
68Renin-angiotensin system_Homo sapiens_hsa046140.96720044
69Pyruvate metabolism_Homo sapiens_hsa006200.94512481
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92272315
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92260514
72Lysosome_Homo sapiens_hsa041420.92115198
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91987731
74RNA polymerase_Homo sapiens_hsa030200.91147154
75Sulfur relay system_Homo sapiens_hsa041220.90783988
76Endocytosis_Homo sapiens_hsa041440.90327201
77Mineral absorption_Homo sapiens_hsa049780.89897258
78Oxidative phosphorylation_Homo sapiens_hsa001900.89767498
79Toxoplasmosis_Homo sapiens_hsa051450.88620711
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88235590
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86613013
82TNF signaling pathway_Homo sapiens_hsa046680.86454264
83Parkinsons disease_Homo sapiens_hsa050120.86343825
84Mismatch repair_Homo sapiens_hsa034300.86046158
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83096114
86Osteoclast differentiation_Homo sapiens_hsa043800.82618138
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82303197
88Chronic myeloid leukemia_Homo sapiens_hsa052200.81322063
89Vitamin B6 metabolism_Homo sapiens_hsa007500.81080214
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.78623953
91Retinol metabolism_Homo sapiens_hsa008300.77391129
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77231197
93Sphingolipid metabolism_Homo sapiens_hsa006000.77160846
94Tuberculosis_Homo sapiens_hsa051520.76338914
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.76136996
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76020617
97Ether lipid metabolism_Homo sapiens_hsa005650.75333656
98Arginine biosynthesis_Homo sapiens_hsa002200.73269269
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.73031408
100Acute myeloid leukemia_Homo sapiens_hsa052210.71472723
101Pancreatic cancer_Homo sapiens_hsa052120.68463830
102Hepatitis C_Homo sapiens_hsa051600.67752980
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.67414614
104Base excision repair_Homo sapiens_hsa034100.67403849
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67021875
106Pyrimidine metabolism_Homo sapiens_hsa002400.66855138
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.66589910
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66210790
109Selenocompound metabolism_Homo sapiens_hsa004500.65454097
110Prion diseases_Homo sapiens_hsa050200.65306765
111Hematopoietic cell lineage_Homo sapiens_hsa046400.64907923
112Influenza A_Homo sapiens_hsa051640.64171281
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63935276
114Metabolic pathways_Homo sapiens_hsa011000.63615419
115Rheumatoid arthritis_Homo sapiens_hsa053230.63520870
116Tyrosine metabolism_Homo sapiens_hsa003500.63306599
117Staphylococcus aureus infection_Homo sapiens_hsa051500.62846466
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62049166
119Glycerolipid metabolism_Homo sapiens_hsa005610.61894501
120Hepatitis B_Homo sapiens_hsa051610.61259539
121Nitrogen metabolism_Homo sapiens_hsa009100.60621252
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60276991
123ECM-receptor interaction_Homo sapiens_hsa045120.58384348
124Viral carcinogenesis_Homo sapiens_hsa052030.56695167
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.56306921
126Tight junction_Homo sapiens_hsa045300.55985437
127Nucleotide excision repair_Homo sapiens_hsa034200.55133514
128HTLV-I infection_Homo sapiens_hsa051660.54272664
129Antigen processing and presentation_Homo sapiens_hsa046120.53796386
130Butanoate metabolism_Homo sapiens_hsa006500.53556996
131Homologous recombination_Homo sapiens_hsa034400.53128588
132Phenylalanine metabolism_Homo sapiens_hsa003600.52002955
133Protein export_Homo sapiens_hsa030600.50489766
134Dilated cardiomyopathy_Homo sapiens_hsa054140.49919799
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49182077
136Legionellosis_Homo sapiens_hsa051340.49019284
137p53 signaling pathway_Homo sapiens_hsa041150.48638434
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48045385
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46131211
140Huntingtons disease_Homo sapiens_hsa050160.45785941
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45616594
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44999558
143Small cell lung cancer_Homo sapiens_hsa052220.44593493
144Complement and coagulation cascades_Homo sapiens_hsa046100.44542784
145Protein digestion and absorption_Homo sapiens_hsa049740.43929297
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42959640
147Adherens junction_Homo sapiens_hsa045200.41985039
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41831024
149Epstein-Barr virus infection_Homo sapiens_hsa051690.41799489
150Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40686087
151Platelet activation_Homo sapiens_hsa046110.40205335
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.39959943
153Herpes simplex infection_Homo sapiens_hsa051680.35310395
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34532263
155Thyroid cancer_Homo sapiens_hsa052160.34173353
156Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33336077
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31236196
158Notch signaling pathway_Homo sapiens_hsa043300.30919187

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