PLIN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.72490334
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.72490334
3L-phenylalanine metabolic process (GO:0006558)5.67468197
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.67468197
5lysine metabolic process (GO:0006553)5.44019132
6lysine catabolic process (GO:0006554)5.44019132
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.32160011
8exogenous drug catabolic process (GO:0042738)5.28772930
9fatty acid beta-oxidation (GO:0006635)5.24413265
10fatty acid transmembrane transport (GO:1902001)5.16452480
11aromatic amino acid family catabolic process (GO:0009074)5.11143981
12glyoxylate metabolic process (GO:0046487)5.11082859
13carnitine shuttle (GO:0006853)5.10459595
14alpha-linolenic acid metabolic process (GO:0036109)4.98725758
15drug catabolic process (GO:0042737)4.94624638
16kynurenine metabolic process (GO:0070189)4.94052780
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90170516
182-oxoglutarate metabolic process (GO:0006103)4.77720467
19fatty acid oxidation (GO:0019395)4.74549105
20amino-acid betaine metabolic process (GO:0006577)4.73994966
21fatty acid catabolic process (GO:0009062)4.72865007
22cellular ketone body metabolic process (GO:0046950)4.66912949
23lipid oxidation (GO:0034440)4.66653370
24acetyl-CoA metabolic process (GO:0006084)4.61221675
25tryptophan catabolic process (GO:0006569)4.61111810
26indole-containing compound catabolic process (GO:0042436)4.61111810
27indolalkylamine catabolic process (GO:0046218)4.61111810
28tricarboxylic acid cycle (GO:0006099)4.60217115
29bile acid biosynthetic process (GO:0006699)4.60163094
30* regulation of sequestering of triglyceride (GO:0010889)4.49764561
31short-chain fatty acid metabolic process (GO:0046459)4.43482123
32aspartate family amino acid catabolic process (GO:0009068)4.39943699
33* regulation of triglyceride catabolic process (GO:0010896)4.38763454
34urea cycle (GO:0000050)4.38585216
35urea metabolic process (GO:0019627)4.38585216
36monocarboxylic acid catabolic process (GO:0072329)4.37213706
37tryptophan metabolic process (GO:0006568)4.34904434
38sulfur amino acid catabolic process (GO:0000098)4.27300948
39high-density lipoprotein particle remodeling (GO:0034375)4.24413372
40carnitine metabolic process (GO:0009437)4.23882386
41behavioral response to nicotine (GO:0035095)4.22810979
42serine family amino acid catabolic process (GO:0009071)4.19637803
43branched-chain amino acid catabolic process (GO:0009083)4.18337653
44cysteine metabolic process (GO:0006534)4.12594163
45negative regulation of fibrinolysis (GO:0051918)4.12516164
46triglyceride homeostasis (GO:0070328)4.10618536
47acylglycerol homeostasis (GO:0055090)4.10618536
48nitrogen cycle metabolic process (GO:0071941)4.09430240
49complement activation, alternative pathway (GO:0006957)4.08901350
50alpha-amino acid catabolic process (GO:1901606)4.05873618
51homocysteine metabolic process (GO:0050667)4.03672024
52ketone body metabolic process (GO:1902224)4.01896171
53biotin metabolic process (GO:0006768)4.01652488
54regulation of protein activation cascade (GO:2000257)4.00077416
55protein carboxylation (GO:0018214)3.99687349
56peptidyl-glutamic acid carboxylation (GO:0017187)3.99687349
57* regulation of fatty acid oxidation (GO:0046320)3.97261496
58regulation of fibrinolysis (GO:0051917)3.96843550
59carnitine transmembrane transport (GO:1902603)3.96614903
60plasma lipoprotein particle clearance (GO:0034381)3.92644607
61valine metabolic process (GO:0006573)3.92126441
62negative regulation of fatty acid biosynthetic process (GO:0045717)3.90425878
63bile acid metabolic process (GO:0008206)3.87566918
64coenzyme catabolic process (GO:0009109)3.86263471
65organic acid catabolic process (GO:0016054)3.85339527
66carboxylic acid catabolic process (GO:0046395)3.85339527
67regulation of cholesterol esterification (GO:0010872)3.84057635
68ethanol oxidation (GO:0006069)3.83766537
69cellular amino acid catabolic process (GO:0009063)3.81188728
70phospholipid homeostasis (GO:0055091)3.80811080
71macromolecular complex remodeling (GO:0034367)3.80457619
72plasma lipoprotein particle remodeling (GO:0034369)3.80457619
73protein-lipid complex remodeling (GO:0034368)3.80457619
74branched-chain amino acid metabolic process (GO:0009081)3.78002957
75carnitine transport (GO:0015879)3.76216364
76amino-acid betaine transport (GO:0015838)3.76216364
77aromatic amino acid family metabolic process (GO:0009072)3.75299000
78NADH metabolic process (GO:0006734)3.75016981
79regulation of complement activation (GO:0030449)3.72798524
80reverse cholesterol transport (GO:0043691)3.72552536
81dicarboxylic acid biosynthetic process (GO:0043650)3.67236698
82omega-hydroxylase P450 pathway (GO:0097267)3.66350253
83regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.65327812
84* positive regulation of fatty acid beta-oxidation (GO:0032000)3.64032702
85* positive regulation of fatty acid oxidation (GO:0046321)3.63710394
86tyrosine metabolic process (GO:0006570)3.61373191
87oxidative demethylation (GO:0070989)3.57510317
88S-adenosylmethionine metabolic process (GO:0046500)3.56522560
89indolalkylamine metabolic process (GO:0006586)3.56362126
90phospholipid efflux (GO:0033700)3.56308376
91* positive regulation of lipid catabolic process (GO:0050996)3.55999794
92succinate metabolic process (GO:0006105)3.54881506
93regulation of cholesterol metabolic process (GO:0090181)3.52175575
94tricarboxylic acid metabolic process (GO:0072350)3.46482661
95glutamate metabolic process (GO:0006536)3.42164020
96oxaloacetate metabolic process (GO:0006107)3.41169694
97cellular modified amino acid catabolic process (GO:0042219)3.31338307
98L-fucose catabolic process (GO:0042355)3.31026400
99fucose catabolic process (GO:0019317)3.31026400
100L-fucose metabolic process (GO:0042354)3.31026400
101regulation of acyl-CoA biosynthetic process (GO:0050812)3.28853799
102glycine metabolic process (GO:0006544)3.27476409
103thioester metabolic process (GO:0035383)3.27441755
104acyl-CoA metabolic process (GO:0006637)3.27441755
105negative regulation of sterol transport (GO:0032372)3.27304499
106negative regulation of cholesterol transport (GO:0032375)3.27304499
107benzene-containing compound metabolic process (GO:0042537)3.24792530
108amine catabolic process (GO:0009310)3.23544315
109cellular biogenic amine catabolic process (GO:0042402)3.23544315
110positive regulation of lipoprotein lipase activity (GO:0051006)3.23143272
111positive regulation of triglyceride lipase activity (GO:0061365)3.23143272
112epoxygenase P450 pathway (GO:0019373)3.22340316
113regulation of hexokinase activity (GO:1903299)3.20557954
114regulation of glucokinase activity (GO:0033131)3.20557954
115detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20181852
116regulation of skeletal muscle contraction (GO:0014819)3.17569819
117actin-myosin filament sliding (GO:0033275)3.14839070
118muscle filament sliding (GO:0030049)3.14839070
119amino acid salvage (GO:0043102)3.04009098
120L-methionine salvage (GO:0071267)3.04009098
121L-methionine biosynthetic process (GO:0071265)3.04009098
122synaptic transmission, cholinergic (GO:0007271)3.01760059
123regulation of memory T cell differentiation (GO:0043380)2.96979195
124ubiquinone biosynthetic process (GO:0006744)2.96687791
125drug metabolic process (GO:0017144)2.93341355
126arginine metabolic process (GO:0006525)2.91920970
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91565224
128detection of light stimulus involved in sensory perception (GO:0050962)2.89124378
129detection of light stimulus involved in visual perception (GO:0050908)2.89124378
130regulation of action potential (GO:0098900)2.86114609
131quinone biosynthetic process (GO:1901663)2.82843346
132NAD biosynthetic process (GO:0009435)2.82768155
133ethanol metabolic process (GO:0006067)2.80956892
134alkaloid metabolic process (GO:0009820)2.78746032
135arginine catabolic process (GO:0006527)2.72825372
136flavonoid metabolic process (GO:0009812)2.71797269
137dopamine transport (GO:0015872)2.69487632
138indole-containing compound metabolic process (GO:0042430)2.66080007
139alanine transport (GO:0032328)2.65432010
140creatine metabolic process (GO:0006600)2.61950661
141ubiquinone metabolic process (GO:0006743)2.60812098
142imidazole-containing compound metabolic process (GO:0052803)2.57995858
143epithelial cilium movement (GO:0003351)2.57034871
144DNA deamination (GO:0045006)2.56783393
145auditory receptor cell stereocilium organization (GO:0060088)2.55630221
146phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54134860
147regulation of relaxation of muscle (GO:1901077)2.52726334
148sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52512525
149actin-mediated cell contraction (GO:0070252)2.51775956
150pyrimidine nucleobase catabolic process (GO:0006208)2.51436056
151membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49754939
152axoneme assembly (GO:0035082)2.47433939
153methionine biosynthetic process (GO:0009086)2.46039567
154brown fat cell differentiation (GO:0050873)2.43656052
155piRNA metabolic process (GO:0034587)2.43492330
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43240439
157water-soluble vitamin biosynthetic process (GO:0042364)2.42204256
158xenobiotic catabolic process (GO:0042178)2.41101020
159myofibril assembly (GO:0030239)2.40670336
160glycerol metabolic process (GO:0006071)2.39983519
161pyridine nucleotide biosynthetic process (GO:0019363)2.38885114
162nicotinamide nucleotide biosynthetic process (GO:0019359)2.38885114
163skeletal muscle contraction (GO:0003009)2.38336395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.33705305
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.11953640
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27382608
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.67177782
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.11879686
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80028603
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.10153493
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.97440575
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93850808
10EZH2_22144423_ChIP-Seq_EOC_Human3.23652380
11ZNF274_21170338_ChIP-Seq_K562_Hela3.09311276
12VDR_22108803_ChIP-Seq_LS180_Human3.00191227
13GBX2_23144817_ChIP-Seq_PC3_Human2.80375769
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.76381043
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.46842972
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42414122
17IGF1R_20145208_ChIP-Seq_DFB_Human2.33950404
18CLOCK_20551151_ChIP-Seq_293T_Human2.23491798
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20280023
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06908383
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3330083
22ER_23166858_ChIP-Seq_MCF-7_Human1.95320932
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93669060
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89224041
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88228001
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81034682
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80755254
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72718062
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.71607391
30TAF15_26573619_Chip-Seq_HEK293_Human1.68998847
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68698286
32ZNF263_19887448_ChIP-Seq_K562_Human1.63865964
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62319590
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59022421
35GATA1_22025678_ChIP-Seq_K562_Human1.55711963
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.52171449
37P300_19829295_ChIP-Seq_ESCs_Human1.47498591
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.47162292
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.47162292
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45783619
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45457248
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40184627
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.39754030
44DROSHA_22980978_ChIP-Seq_HELA_Human1.39599882
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36816948
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36538385
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.36535991
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.35934334
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34698819
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.33186644
51AR_25329375_ChIP-Seq_VCAP_Human1.32771707
52CBP_20019798_ChIP-Seq_JUKART_Human1.32327416
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32327416
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30685901
55TCF4_23295773_ChIP-Seq_U87_Human1.29206343
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29175098
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28985736
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.28985736
59STAT3_23295773_ChIP-Seq_U87_Human1.28882055
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.28833437
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.28198335
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27863682
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26952178
64NANOG_19829295_ChIP-Seq_ESCs_Human1.26685079
65SOX2_19829295_ChIP-Seq_ESCs_Human1.26685079
66TP53_22573176_ChIP-Seq_HFKS_Human1.26522201
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25642185
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.25394314
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.24909370
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24705051
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22622292
72NCOR_22424771_ChIP-Seq_293T_Human1.22383102
73HNF4A_19822575_ChIP-Seq_HepG2_Human1.21677045
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21456656
75SMAD4_21799915_ChIP-Seq_A2780_Human1.21348831
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21045257
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21045257
78FUS_26573619_Chip-Seq_HEK293_Human1.21002746
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20049217
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19705915
81REST_21632747_ChIP-Seq_MESCs_Mouse1.19272363
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19043859
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19024323
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15444895
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.15147385
86NANOG_20526341_ChIP-Seq_ESCs_Human1.14286897
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13554954
88TCF4_22108803_ChIP-Seq_LS180_Human1.12998804
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12886101
90RUNX2_22187159_ChIP-Seq_PCA_Human1.10855785
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10814383
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.10461283
93MYC_19829295_ChIP-Seq_ESCs_Human1.09564344
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08954871
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08437539
96ERA_21632823_ChIP-Seq_H3396_Human1.08314267
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07413939
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05245325
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.04854679
100HTT_18923047_ChIP-ChIP_STHdh_Human1.04493573
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04013014
102IRF1_19129219_ChIP-ChIP_H3396_Human1.03869119
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.02806795
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.02745259
105EWS_26573619_Chip-Seq_HEK293_Human1.01776767
106CDX2_22108803_ChIP-Seq_LS180_Human1.01653570
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01194992
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00412282
109AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00145657
110AR_21572438_ChIP-Seq_LNCaP_Human0.99046276
111* EZH2_27294783_Chip-Seq_ESCs_Mouse0.97849091
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95741811
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90901710
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85944488
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.83366390
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82279104
117* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82217350
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80278333
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79055921
120* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.73473360
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70988858
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69773053
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69559169
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69504167
125CEBPB_22108803_ChIP-Seq_LS180_Human0.68791606
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67995111
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67995111
128BCAT_22108803_ChIP-Seq_LS180_Human0.66162790
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64178725
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64159843
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63908026
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63749912
133EGR1_19032775_ChIP-ChIP_M12_Human0.63668453
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63388605
135GATA1_19941826_ChIP-Seq_K562_Human0.62749879
136GATA4_25053715_ChIP-Seq_YYC3_Human0.62522959
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62187500
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61069731
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60073985
140GATA2_19941826_ChIP-Seq_K562_Human0.58270913
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57382918
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.56870563
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.56684584
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56344845
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.55009735
146LXR_22292898_ChIP-Seq_THP-1_Human0.54677661
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.54545443
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.54380994
149TAF2_19829295_ChIP-Seq_ESCs_Human0.52552429
150CBP_21632823_ChIP-Seq_H3396_Human0.52507715
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51718347
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50517757
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50492035
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.50403407
155AR_20517297_ChIP-Seq_VCAP_Human0.50387358
156CDX2_19796622_ChIP-Seq_MESCs_Mouse0.50187728
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.49899901
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.49307567
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48309908
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.47677546
161OCT4_20526341_ChIP-Seq_ESCs_Human0.47446379
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.46857404
163ERG_20517297_ChIP-Seq_VCAP_Human0.46709370
164GATA2_21666600_ChIP-Seq_HMVEC_Human0.46241593
165* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45018002
166FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44298826
167CTCF_27219007_Chip-Seq_Bcells_Human0.43807156
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.43606896
169CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.43365048
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.42753727
171* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42548939
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.41877962
173CSB_26484114_Chip-Seq_FIBROBLAST_Human0.41084819
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40935937
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.40704509
176* SPI1_20517297_ChIP-Seq_HL60_Human0.40461353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.97602610
2MP0005360_urolithiasis5.29753895
3MP0005085_abnormal_gallbladder_physiolo5.00003666
4MP0005365_abnormal_bile_salt4.80030946
5MP0002837_dystrophic_cardiac_calcinosis4.14867396
6MP0008875_abnormal_xenobiotic_pharmacok3.62664260
7MP0003806_abnormal_nucleotide_metabolis3.46283860
8MP0003646_muscle_fatigue3.27531192
9MP0004145_abnormal_muscle_electrophysio3.10255355
10MP0010329_abnormal_lipoprotein_level3.10001274
11MP0003252_abnormal_bile_duct2.99159624
12MP0005670_abnormal_white_adipose2.92061519
13MP0009840_abnormal_foam_cell2.78474773
14MP0004130_abnormal_muscle_cell2.67747709
15MP0005332_abnormal_amino_acid2.53766024
16MP0004084_abnormal_cardiac_muscle2.35229504
17MP0003195_calcinosis2.31975821
18MP0005330_cardiomyopathy2.28770249
19MP0005083_abnormal_biliary_tract2.19746539
20MP0000751_myopathy2.14490475
21MP0004215_abnormal_myocardial_fiber2.14427199
22MP0002118_abnormal_lipid_homeostasis2.11353967
23MP0005666_abnormal_adipose_tissue2.10090457
24MP0003191_abnormal_cellular_cholesterol2.08445650
25MP0006036_abnormal_mitochondrial_physio2.02996175
26MP0008872_abnormal_physiological_respon1.94282230
27MP0004036_abnormal_muscle_relaxation1.93314415
28MP0001986_abnormal_taste_sensitivity1.90933668
29MP0000609_abnormal_liver_physiology1.88375237
30MP0005551_abnormal_eye_electrophysiolog1.84099453
31MP0001666_abnormal_nutrient_absorption1.79868399
32MP0005319_abnormal_enzyme/_coenzyme1.77355384
33MP0000749_muscle_degeneration1.68320176
34MP0002638_abnormal_pupillary_reflex1.67965074
35MP0002971_abnormal_brown_adipose1.65907846
36MP0001968_abnormal_touch/_nociception1.56267595
37MP0005584_abnormal_enzyme/coenzyme_acti1.53568797
38MP0004087_abnormal_muscle_fiber1.52950115
39MP0005451_abnormal_body_composition1.49042446
40MP0008775_abnormal_heart_ventricle1.48565513
41MP0005646_abnormal_pituitary_gland1.47785809
42MP0002972_abnormal_cardiac_muscle1.45868501
43MP0005385_cardiovascular_system_phenoty1.45275494
44MP0001544_abnormal_cardiovascular_syste1.45275494
45MP0006138_congestive_heart_failure1.41780816
46MP0002138_abnormal_hepatobiliary_system1.37805750
47MP0004019_abnormal_vitamin_homeostasis1.37166481
48MP0002269_muscular_atrophy1.35242402
49MP0003136_yellow_coat_color1.32438479
50MP0004185_abnormal_adipocyte_glucose1.32105185
51MP0010630_abnormal_cardiac_muscle1.30314096
52MP0002102_abnormal_ear_morphology1.28622373
53MP0009745_abnormal_behavioral_response1.28011042
54MP0005620_abnormal_muscle_contractility1.27161836
55MP0003137_abnormal_impulse_conducting1.27083300
56MP0005167_abnormal_blood-brain_barrier1.25411382
57MP0005645_abnormal_hypothalamus_physiol1.25298691
58MP0005535_abnormal_body_temperature1.24724681
59MP0001501_abnormal_sleep_pattern1.23685285
60MP0000372_irregular_coat_pigmentation1.23614697
61MP0001764_abnormal_homeostasis1.23375902
62MP0010368_abnormal_lymphatic_system1.22264243
63MP0005375_adipose_tissue_phenotype1.21525513
64MP0006276_abnormal_autonomic_nervous1.20356580
65MP0002736_abnormal_nociception_after1.19451185
66MP0004142_abnormal_muscle_tone1.19015437
67MP0005253_abnormal_eye_physiology1.18266208
68MP0006035_abnormal_mitochondrial_morpho1.17293325
69MP0003705_abnormal_hypodermis_morpholog1.16630212
70MP0003186_abnormal_redox_activity1.14609878
71MP0009697_abnormal_copulation1.12768288
72MP0002078_abnormal_glucose_homeostasis1.11522876
73MP0009643_abnormal_urine_homeostasis1.11055735
74MP0004885_abnormal_endolymph1.10848356
75MP0003868_abnormal_feces_composition1.10517344
76MP0003221_abnormal_cardiomyocyte_apopto1.10129912
77MP0006292_abnormal_olfactory_placode1.09566198
78MP0004147_increased_porphyrin_level1.08119688
79MP0004133_heterotaxia1.07433713
80MP0005334_abnormal_fat_pad1.07361367
81MP0002277_abnormal_respiratory_mucosa1.06284872
82MP0008877_abnormal_DNA_methylation1.05169801
83MP0005266_abnormal_metabolism1.05104907
84MP0000750_abnormal_muscle_regeneration1.04386623
85MP0002332_abnormal_exercise_endurance1.02892906
86MP0004484_altered_response_of1.02423010
87MP0002272_abnormal_nervous_system1.01058727
88MP0001485_abnormal_pinna_reflex0.99771872
89MP0002106_abnormal_muscle_physiology0.96291335
90MP0005084_abnormal_gallbladder_morpholo0.95533477
91MP0009046_muscle_twitch0.95331565
92MP0003656_abnormal_erythrocyte_physiolo0.93738831
93MP0000427_abnormal_hair_cycle0.93009582
94MP0004085_abnormal_heartbeat0.92752390
95MP0000569_abnormal_digit_pigmentation0.92124739
96MP0004924_abnormal_behavior0.91625851
97MP0005386_behavior/neurological_phenoty0.91625851
98MP0001486_abnormal_startle_reflex0.90802977
99MP0000598_abnormal_liver_morphology0.89938076
100MP0002234_abnormal_pharynx_morphology0.89914839
101MP0002735_abnormal_chemical_nociception0.89760445
102MP0003878_abnormal_ear_physiology0.89281867
103MP0005377_hearing/vestibular/ear_phenot0.89281867
104MP0000747_muscle_weakness0.89115152
105MP0003011_delayed_dark_adaptation0.87712444
106MP0009763_increased_sensitivity_to0.85727876
107MP0009115_abnormal_fat_cell0.84729360
108MP0006072_abnormal_retinal_apoptosis0.84178501
109MP0000759_abnormal_skeletal_muscle0.82563504
110MP0003724_increased_susceptibility_to0.82517443
111MP0005647_abnormal_sex_gland0.82149298
112MP0000230_abnormal_systemic_arterial0.79114226
113MP0002928_abnormal_bile_duct0.78958301
114MP0005376_homeostasis/metabolism_phenot0.78539224
115MP0005369_muscle_phenotype0.77232427
116MP0001661_extended_life_span0.76787350
117MP0009642_abnormal_blood_homeostasis0.75814395
118MP0000631_abnormal_neuroendocrine_gland0.74948622
119MP0005448_abnormal_energy_balance0.74421859
120MP0003828_pulmonary_edema0.73341276
121MP0002970_abnormal_white_adipose0.72880990
122MP0001502_abnormal_circadian_rhythm0.72710050
123MP0002693_abnormal_pancreas_physiology0.71961592
124MP0002064_seizures0.71442800
125MP0000343_altered_response_to0.70503582
126MP0002108_abnormal_muscle_morphology0.69519211
127MP0009780_abnormal_chondrocyte_physiolo0.68874545
128MP0002127_abnormal_cardiovascular_syste0.68558243
129MP0001970_abnormal_pain_threshold0.68159269
130MP0009764_decreased_sensitivity_to0.65315828
131MP0000604_amyloidosis0.64765890
132MP0005165_increased_susceptibility_to0.63651040
133MP0003690_abnormal_glial_cell0.62897590
134MP0008469_abnormal_protein_level0.60666970
135MP0004510_myositis0.57714104
136MP0005636_abnormal_mineral_homeostasis0.57001561
137MP0002822_catalepsy0.55631704
138MP0001853_heart_inflammation0.53064553
139MP0001756_abnormal_urination0.52627365
140MP0000003_abnormal_adipose_tissue0.52224211
141MP0004043_abnormal_pH_regulation0.52180363
142MP0003953_abnormal_hormone_level0.50434057
143MP0002876_abnormal_thyroid_physiology0.49783185
144MP0002254_reproductive_system_inflammat0.49064909
145MP0003950_abnormal_plasma_membrane0.48322971
146MP0002128_abnormal_blood_circulation0.46415821
147MP0004233_abnormal_muscle_weight0.44703341

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.13660079
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.83881090
3Xanthomatosis (HP:0000991)4.81968373
4Deep venous thrombosis (HP:0002625)4.80377386
5Hyperammonemia (HP:0001987)4.76610106
6Abnormality of fatty-acid metabolism (HP:0004359)4.73943586
7Intrahepatic cholestasis (HP:0001406)4.71535295
8Hyperglycinuria (HP:0003108)4.70300091
9Ketosis (HP:0001946)4.59292598
10Hyperlipoproteinemia (HP:0010980)4.43991756
11Myoglobinuria (HP:0002913)4.33340595
12Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25210250
13Abnormality of glycine metabolism (HP:0010895)4.24578469
14Abnormality of serine family amino acid metabolism (HP:0010894)4.24578469
15Ketoacidosis (HP:0001993)4.13306577
16Abnormality of dicarboxylic acid metabolism (HP:0010995)4.12688781
17Dicarboxylic aciduria (HP:0003215)4.12688781
18Prolonged partial thromboplastin time (HP:0003645)4.08297486
19Muscle fiber inclusion bodies (HP:0100299)4.07887030
20Hypobetalipoproteinemia (HP:0003563)4.04146998
21Nemaline bodies (HP:0003798)4.00201863
22Hypoalphalipoproteinemia (HP:0003233)3.98576594
23Hyperglycinemia (HP:0002154)3.94168650
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.92638883
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.91821531
26Hypolipoproteinemia (HP:0010981)3.76275282
27Sudden death (HP:0001699)3.65697454
28Pancreatic cysts (HP:0001737)3.65631762
29Cerebral edema (HP:0002181)3.61796895
30Rhabdomyolysis (HP:0003201)3.60010408
31Epidermoid cyst (HP:0200040)3.56337919
32Complement deficiency (HP:0004431)3.54871093
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.53364060
34Exercise-induced myalgia (HP:0003738)3.47517096
35Ventricular tachycardia (HP:0004756)3.27875811
36Hepatic necrosis (HP:0002605)3.27548128
37Pancreatic fibrosis (HP:0100732)3.27326935
38True hermaphroditism (HP:0010459)3.23099189
39Molar tooth sign on MRI (HP:0002419)3.22317976
40Abnormality of midbrain morphology (HP:0002418)3.22317976
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18751940
42Congenital stationary night blindness (HP:0007642)3.18683108
43Generalized aminoaciduria (HP:0002909)3.13866459
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11647423
45Hyperventilation (HP:0002883)3.10573247
46Lethargy (HP:0001254)3.10207376
47Abnormality of the renal cortex (HP:0011035)3.05016533
48Type II lissencephaly (HP:0007260)3.04926020
49Metabolic acidosis (HP:0001942)3.04877611
50Abnormality of methionine metabolism (HP:0010901)3.04521099
51Abnormality of serum amino acid levels (HP:0003112)3.03943564
52Nephronophthisis (HP:0000090)2.98804211
53Joint hemorrhage (HP:0005261)2.96830836
54Palpitations (HP:0001962)2.92548300
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.85317451
56Abnormality of the common coagulation pathway (HP:0010990)2.83421454
57Acute encephalopathy (HP:0006846)2.79758637
58Exercise-induced muscle cramps (HP:0003710)2.77657634
59Calf muscle hypertrophy (HP:0008981)2.77104484
60Right ventricular cardiomyopathy (HP:0011663)2.76659480
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76263180
62Abnormality of alanine metabolism (HP:0010916)2.76263180
63Hyperalaninemia (HP:0003348)2.76263180
64Skin nodule (HP:0200036)2.74517977
65Increased muscle lipid content (HP:0009058)2.74272676
66Type 1 muscle fiber predominance (HP:0003803)2.70227429
67Renal cortical cysts (HP:0000803)2.69017388
68Lipoatrophy (HP:0100578)2.64144891
69Nausea (HP:0002018)2.64005430
70Atrioventricular block (HP:0001678)2.63282658
71Hypercholesterolemia (HP:0003124)2.62586338
72Abnormality of the renal medulla (HP:0100957)2.61152029
73Hyperinsulinemic hypoglycemia (HP:0000825)2.58701526
74Pendular nystagmus (HP:0012043)2.54395925
75Vomiting (HP:0002013)2.53584102
76Bile duct proliferation (HP:0001408)2.51289532
77Abnormal biliary tract physiology (HP:0012439)2.51289532
78Hyporeflexia of lower limbs (HP:0002600)2.50253059
79Attenuation of retinal blood vessels (HP:0007843)2.49311041
80Atrial fibrillation (HP:0005110)2.48561056
81Dilated cardiomyopathy (HP:0001644)2.47408362
82Abnormality of the intrinsic pathway (HP:0010989)2.47040398
83Muscle hypertrophy of the lower extremities (HP:0008968)2.46902640
84Abnormality of complement system (HP:0005339)2.45739149
85Hypoglycemic seizures (HP:0002173)2.42049407
86Tubular atrophy (HP:0000092)2.41418303
87Fat malabsorption (HP:0002630)2.40726812
88Muscle fiber splitting (HP:0003555)2.38680642
89Proximal tubulopathy (HP:0000114)2.38620943
90Abnormal mitochondria in muscle tissue (HP:0008316)2.38320695
91Hyperbilirubinemia (HP:0002904)2.37894433
92Cystic liver disease (HP:0006706)2.36803395
93Delayed CNS myelination (HP:0002188)2.35961570
94Abolished electroretinogram (ERG) (HP:0000550)2.35714753
95Cholelithiasis (HP:0001081)2.35285964
96Abnormal drinking behavior (HP:0030082)2.34870330
97Polydipsia (HP:0001959)2.34870330
98Heart block (HP:0012722)2.34489000
99Decreased central vision (HP:0007663)2.33224712
100Large for gestational age (HP:0001520)2.31263747
101Lactic acidosis (HP:0003128)2.31008147
102Hepatocellular necrosis (HP:0001404)2.29525376
103Primary atrial arrhythmia (HP:0001692)2.26405126
104Abnormal gallbladder morphology (HP:0012437)2.26213976
105Asymmetric septal hypertrophy (HP:0001670)2.25655125
106Acute necrotizing encephalopathy (HP:0006965)2.25144676
107Abnormal rod and cone electroretinograms (HP:0008323)2.22993625
108Hyperglycemia (HP:0003074)2.21726294
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21710168
110Genetic anticipation (HP:0003743)2.20962494
111Absent/shortened dynein arms (HP:0200106)2.19661008
112Dynein arm defect of respiratory motile cilia (HP:0012255)2.19661008
113Chronic hepatic failure (HP:0100626)2.18214069
114Abnormality of purine metabolism (HP:0004352)2.18089076
115Abnormal atrioventricular conduction (HP:0005150)2.17885306
116Fair hair (HP:0002286)2.17405310
117Bundle branch block (HP:0011710)2.17033793
118Abnormality of nucleobase metabolism (HP:0010932)2.16841998
119Supraventricular tachycardia (HP:0004755)2.16713450
120Syncope (HP:0001279)2.15989461
121Abnormality of pyrimidine metabolism (HP:0004353)2.14347844
122Gaze-evoked nystagmus (HP:0000640)2.12994210
123Supraventricular arrhythmia (HP:0005115)2.12082840
124Abnormality of the calf musculature (HP:0001430)2.11993752
125Cerebellar dysplasia (HP:0007033)2.11394922
126Ragged-red muscle fibers (HP:0003200)2.10408711
127EMG: myopathic abnormalities (HP:0003458)2.08875667
128Abnormal respiratory epithelium morphology (HP:0012253)2.08411169
129Abnormal respiratory motile cilium morphology (HP:0005938)2.08411169
130Progressive cerebellar ataxia (HP:0002073)2.08296635
131Rimmed vacuoles (HP:0003805)2.08291507
132Gout (HP:0001997)2.07999436
133Increased connective tissue (HP:0009025)2.06143111
134Myocardial infarction (HP:0001658)2.05423651
135Medial flaring of the eyebrow (HP:0010747)2.05061175
136Abnormality of glycolysis (HP:0004366)2.04552256
137Increased serum pyruvate (HP:0003542)2.04552256
138Hypochromic microcytic anemia (HP:0004840)2.04001466
139Late onset (HP:0003584)2.03611406
140Abnormality of proline metabolism (HP:0010907)2.03229946
141Hydroxyprolinuria (HP:0003080)2.03229946
142Inability to walk (HP:0002540)2.02849084
143Conjunctival hamartoma (HP:0100780)2.01419149
144Congenital hepatic fibrosis (HP:0002612)1.99441896
145Distal arthrogryposis (HP:0005684)1.98980184
146Increased intramyocellular lipid droplets (HP:0012240)1.98716187
147Hepatocellular carcinoma (HP:0001402)1.97127290
148Severe muscular hypotonia (HP:0006829)1.95185496
149Broad-based gait (HP:0002136)1.95053022
150Increased corneal curvature (HP:0100692)1.95017059
151Keratoconus (HP:0000563)1.95017059
152Methylmalonic aciduria (HP:0012120)1.93620728
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90392736
154Areflexia of lower limbs (HP:0002522)1.89587848
155Stomatitis (HP:0010280)1.89354141
156Mitochondrial inheritance (HP:0001427)1.88996964
157Polyuria (HP:0000103)1.88381101
158Furrowed tongue (HP:0000221)1.81594772
159Decreased circulating renin level (HP:0003351)1.78047800
160Progressive macrocephaly (HP:0004481)1.77161857
161Cerebral palsy (HP:0100021)1.76064589
162Male pseudohermaphroditism (HP:0000037)1.75828043
163Left ventricular hypertrophy (HP:0001712)1.73057053
164Optic disc pallor (HP:0000543)1.72760513
165Absent phalangeal crease (HP:0006109)1.72489090
166Congenital sensorineural hearing impairment (HP:0008527)1.72167661
167Progressive inability to walk (HP:0002505)1.69662241
168Febrile seizures (HP:0002373)1.69338210
169Chorioretinal atrophy (HP:0000533)1.69125668
170Sclerocornea (HP:0000647)1.68837845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.48815018
2TTN3.85125647
3PDK33.50092756
4PDK43.50092756
5TRIB33.29048685
6ADRBK22.89415391
7TIE12.88928214
8SIK12.77298218
9OBSCN2.65990710
10PKN22.64607600
11PINK12.48658096
12GRK12.41181573
13PHKG22.37521241
14PHKG12.37521241
15FGFR42.34052840
16LMTK22.31084399
17INSRR2.28139832
18MYLK2.26055002
19PDK22.11839360
20ERN12.07291698
21WNK31.94639671
22BMPR1B1.93571829
23ACVR1B1.91341438
24OXSR11.84426417
25MAP4K21.78192329
26CASK1.70051319
27PIK3CA1.68225054
28MAPK131.65334379
29PRKAA21.53774279
30CAMK1D1.53144373
31WNK41.47579046
32TNK21.41959336
33NUAK11.39774752
34TXK1.36439119
35FLT31.28893639
36ADRBK11.27084540
37NEK91.23707373
38NEK11.21637404
39CDK191.19943976
40LATS11.13678672
41PRKAA11.13033367
42MAPK111.12799312
43STK38L1.11274519
44ERBB41.11168853
45KDR1.11100729
46MAPK121.10761586
47MAPK151.08920335
48MARK11.08262377
49MUSK1.08173202
50MAP3K71.06575144
51TLK11.06027292
52MAP2K41.05504294
53DMPK1.04972579
54PTK2B1.02578366
55TNIK0.98579823
56CAMK10.92356330
57NTRK30.92024712
58PIK3CG0.91808620
59PRKD10.89756418
60PRKCE0.89638347
61MAP2K30.89161014
62PAK30.87975739
63NLK0.87806817
64MAP3K40.85468312
65GRK70.85378226
66CAMK1G0.85183488
67STK110.82927190
68IRAK10.81677036
69MST1R0.81166928
70PTK60.78407777
71CAMKK20.77988496
72PKN10.77476865
73STK390.77197064
74PRKACG0.76836372
75RIPK10.75388162
76CAMK40.75208277
77TRPM70.74797594
78PDPK10.74171287
79ABL20.74052546
80TGFBR20.73096834
81JAK10.73007930
82MAP3K50.71631943
83MAP3K30.71098860
84SGK30.70749336
85TYK20.69181321
86CAMK2D0.68425249
87FGFR20.66400927
88PRKCG0.66164180
89PRKG10.65838347
90TEC0.65620465
91DYRK20.65481652
92NME10.65448566
93JAK20.65345338
94TAOK30.64082485
95IKBKB0.62068011
96KIT0.61937742
97ERBB30.60296701
98CAMK2G0.60253333
99STK240.60222419
100MARK30.60020741
101EPHB10.59635358
102PDGFRA0.57534570
103FER0.56919287
104PRKCQ0.55418683
105MAPK40.54162176
106PNCK0.53587233
107TGFBR10.53261800
108SGK20.52847293
109PDK10.49033289
110FRK0.47570135
111FGFR30.47017332
112TBK10.46226441
113STK40.45900946
114ROCK10.44689024
115DAPK20.44418926
116CHUK0.43869578
117IRAK40.43340574
118EPHA30.42706577
119GSK3A0.41956317
120NME20.40176800
121STK380.39597207
122PRKACB0.39511633
123MAP2K10.39160850
124ITK0.39127898
125LATS20.38659584
126PRKACA0.37938792
127MAPK70.37801570
128IRAK30.37600588
129MTOR0.37027871
130ICK0.36414795
131PRKCH0.36262909
132MAPKAPK30.34773932
133IKBKE0.33743698
134CAMK2A0.33707295
135AKT20.32885429
136MAP3K110.32376906
137PRKCZ0.32368426
138PRKCA0.32321655
139SYK0.31483174
140MAP2K60.31206607
141SIK20.30894027
142ZAK0.30810681
143SGK2230.30397672
144SGK4940.30397672
145IGF1R0.30270337
146DAPK30.29970889
147MAP2K70.29295607
148RPS6KA50.29138075
149RPS6KL10.28453847
150RPS6KC10.28453847
151CDK40.28396440
152CSNK1A10.28295335
153MKNK20.27690139
154GRK50.27609378
155SGK10.27312694
156TRIM280.27097507
157RPS6KA60.25836829
158MAP3K60.25591310

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.51834327
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50978829
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.41672073
4Propanoate metabolism_Homo sapiens_hsa006403.36885623
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.23074503
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.11292813
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.99398911
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85606359
9Fatty acid metabolism_Homo sapiens_hsa012122.74476599
10Nitrogen metabolism_Homo sapiens_hsa009102.59543989
11Arginine biosynthesis_Homo sapiens_hsa002202.59281911
12Tryptophan metabolism_Homo sapiens_hsa003802.50581216
13Butanoate metabolism_Homo sapiens_hsa006502.40652014
14PPAR signaling pathway_Homo sapiens_hsa033202.40313455
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37257700
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27810207
17Peroxisome_Homo sapiens_hsa041462.07495135
18Carbon metabolism_Homo sapiens_hsa012002.00171956
19Pyruvate metabolism_Homo sapiens_hsa006201.97185979
20Fatty acid elongation_Homo sapiens_hsa000621.94680709
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94388991
22Complement and coagulation cascades_Homo sapiens_hsa046101.91922775
23beta-Alanine metabolism_Homo sapiens_hsa004101.84427615
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77551099
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57188701
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55312132
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49335116
28Phototransduction_Homo sapiens_hsa047441.48048667
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41415929
30Phenylalanine metabolism_Homo sapiens_hsa003601.39515920
31Biosynthesis of amino acids_Homo sapiens_hsa012301.38093690
32Caffeine metabolism_Homo sapiens_hsa002321.33200800
33Chemical carcinogenesis_Homo sapiens_hsa052041.31689476
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30539910
35Starch and sucrose metabolism_Homo sapiens_hsa005001.30269630
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27272204
37Histidine metabolism_Homo sapiens_hsa003401.25438235
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25242439
39Ether lipid metabolism_Homo sapiens_hsa005651.23873776
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.21161946
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18000032
42Tyrosine metabolism_Homo sapiens_hsa003501.17478471
43Retinol metabolism_Homo sapiens_hsa008301.14045502
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.13747914
45Bile secretion_Homo sapiens_hsa049761.12391893
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.12280027
47Staphylococcus aureus infection_Homo sapiens_hsa051501.10488727
48Fat digestion and absorption_Homo sapiens_hsa049751.08987444
49Fatty acid biosynthesis_Homo sapiens_hsa000611.05785735
50Selenocompound metabolism_Homo sapiens_hsa004501.04885718
51Sulfur metabolism_Homo sapiens_hsa009201.03085335
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00217171
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97278019
54Lysine degradation_Homo sapiens_hsa003100.96823809
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92595526
56Arginine and proline metabolism_Homo sapiens_hsa003300.90376622
57Oxidative phosphorylation_Homo sapiens_hsa001900.89824809
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89129131
59ABC transporters_Homo sapiens_hsa020100.89002477
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88041651
61Parkinsons disease_Homo sapiens_hsa050120.86672609
62Folate biosynthesis_Homo sapiens_hsa007900.82038544
63Glycerolipid metabolism_Homo sapiens_hsa005610.79710287
64Cardiac muscle contraction_Homo sapiens_hsa042600.77465600
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74046760
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70086418
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69159771
68Vitamin B6 metabolism_Homo sapiens_hsa007500.69122586
69Olfactory transduction_Homo sapiens_hsa047400.68058170
70Sulfur relay system_Homo sapiens_hsa041220.67710325
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.67491751
72Nicotine addiction_Homo sapiens_hsa050330.64345129
73Regulation of autophagy_Homo sapiens_hsa041400.60808260
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59864415
75Insulin resistance_Homo sapiens_hsa049310.59521395
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59396023
77Alzheimers disease_Homo sapiens_hsa050100.59302983
78Calcium signaling pathway_Homo sapiens_hsa040200.59188008
79Insulin secretion_Homo sapiens_hsa049110.58141249
80Serotonergic synapse_Homo sapiens_hsa047260.55667082
81Morphine addiction_Homo sapiens_hsa050320.54335518
82Taste transduction_Homo sapiens_hsa047420.53872145
83Pentose phosphate pathway_Homo sapiens_hsa000300.53137747
84Metabolic pathways_Homo sapiens_hsa011000.52630751
85Glucagon signaling pathway_Homo sapiens_hsa049220.50731758
86Dilated cardiomyopathy_Homo sapiens_hsa054140.48171981
87Vitamin digestion and absorption_Homo sapiens_hsa049770.47259476
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46697621
89Glutathione metabolism_Homo sapiens_hsa004800.45700417
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45082802
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.42629442
92Huntingtons disease_Homo sapiens_hsa050160.42458834
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41476434
94Circadian entrainment_Homo sapiens_hsa047130.41378511
95AMPK signaling pathway_Homo sapiens_hsa041520.40225828
96GABAergic synapse_Homo sapiens_hsa047270.39851129
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.38302281
98Galactose metabolism_Homo sapiens_hsa000520.38220596
99Fructose and mannose metabolism_Homo sapiens_hsa000510.37798615
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.37718401
101Steroid biosynthesis_Homo sapiens_hsa001000.35681120
102Mineral absorption_Homo sapiens_hsa049780.35164626
103Salivary secretion_Homo sapiens_hsa049700.33462459
104Oxytocin signaling pathway_Homo sapiens_hsa049210.31519064
105Insulin signaling pathway_Homo sapiens_hsa049100.27663466
106Glutamatergic synapse_Homo sapiens_hsa047240.25598030
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.21834625
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18864845
109One carbon pool by folate_Homo sapiens_hsa006700.16670125
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16106522
111Prion diseases_Homo sapiens_hsa050200.13064520
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10757257
113Linoleic acid metabolism_Homo sapiens_hsa005910.10197625
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08102838
115Ovarian steroidogenesis_Homo sapiens_hsa049130.06234428
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.01746986
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01101534
118HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1604179
119Circadian rhythm_Homo sapiens_hsa04710-0.1516079
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1515021
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.1066327
122Type II diabetes mellitus_Homo sapiens_hsa04930-0.0830376
123Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0531267
124Viral myocarditis_Homo sapiens_hsa05416-0.0345348

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