PLK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.85864548
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.85864548
3L-phenylalanine metabolic process (GO:0006558)5.44327908
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.44327908
5aromatic amino acid family catabolic process (GO:0009074)4.95969630
6negative regulation of interleukin-12 production (GO:0032695)4.70409627
7protein carboxylation (GO:0018214)4.63512304
8peptidyl-glutamic acid carboxylation (GO:0017187)4.63512304
9tolerance induction (GO:0002507)4.61606437
10response to peptidoglycan (GO:0032494)4.54426349
11regulation of vitamin D biosynthetic process (GO:0060556)4.40060309
12response to muramyl dipeptide (GO:0032495)4.23804017
13indole-containing compound catabolic process (GO:0042436)4.19881701
14indolalkylamine catabolic process (GO:0046218)4.19881701
15tryptophan catabolic process (GO:0006569)4.19881701
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.17331090
17negative regulation of fibrinolysis (GO:0051918)4.11038341
18regulation of chronic inflammatory response (GO:0002676)4.07845190
19positive regulation of gamma-delta T cell activation (GO:0046645)4.06482444
20positive regulation of lipoprotein lipase activity (GO:0051006)3.97144340
21positive regulation of triglyceride lipase activity (GO:0061365)3.97144340
22bile acid biosynthetic process (GO:0006699)3.94317494
23tryptophan metabolic process (GO:0006568)3.91078823
24high-density lipoprotein particle remodeling (GO:0034375)3.88198130
25NIK/NF-kappaB signaling (GO:0038061)3.88002354
26urea metabolic process (GO:0019627)3.87539393
27urea cycle (GO:0000050)3.87539393
28macrophage activation involved in immune response (GO:0002281)3.87438366
29kynurenine metabolic process (GO:0070189)3.84943225
30lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81983089
31regulation of fibrinolysis (GO:0051917)3.80429165
32acylglycerol homeostasis (GO:0055090)3.80328382
33triglyceride homeostasis (GO:0070328)3.80328382
34fibrinolysis (GO:0042730)3.74645045
35alpha-linolenic acid metabolic process (GO:0036109)3.67845252
36positive regulation by symbiont of host defense response (GO:0052509)3.66937531
37modulation by symbiont of host defense response (GO:0052031)3.66937531
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66937531
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66937531
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.66937531
41modulation by symbiont of host immune response (GO:0052553)3.66937531
42germinal center formation (GO:0002467)3.66198691
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65594114
44negative regulation of cell killing (GO:0031342)3.65594114
45plasma lipoprotein particle clearance (GO:0034381)3.64843769
46regulation of protein activation cascade (GO:2000257)3.64755709
47positive regulation of chemokine biosynthetic process (GO:0045080)3.61770097
48complement activation, alternative pathway (GO:0006957)3.59155247
49cysteine metabolic process (GO:0006534)3.57761936
50regulation of cholesterol homeostasis (GO:2000188)3.57464477
51negative regulation of sterol transport (GO:0032372)3.56769618
52negative regulation of cholesterol transport (GO:0032375)3.56769618
53glyoxylate metabolic process (GO:0046487)3.56533670
54nitrogen cycle metabolic process (GO:0071941)3.56470751
55acute-phase response (GO:0006953)3.55259245
56response to protozoan (GO:0001562)3.52757669
57bile acid metabolic process (GO:0008206)3.51293888
58regulation of triglyceride catabolic process (GO:0010896)3.50927646
59fatty acid elongation (GO:0030497)3.48865110
60aromatic amino acid family metabolic process (GO:0009072)3.47288694
61phospholipid efflux (GO:0033700)3.46072269
62defense response to protozoan (GO:0042832)3.42945144
63regulation of cholesterol esterification (GO:0010872)3.42505677
64negative regulation of cytokine production involved in immune response (GO:0002719)3.41522238
65tyrosine metabolic process (GO:0006570)3.40685667
66regulation of chemokine biosynthetic process (GO:0045073)3.39052086
67myeloid dendritic cell differentiation (GO:0043011)3.38664619
68positive regulation of heat generation (GO:0031652)3.38432055
69regulation of complement activation (GO:0030449)3.37852068
70reverse cholesterol transport (GO:0043691)3.36023232
71regulation of T-helper 1 cell differentiation (GO:0045625)3.33789639
72cholesterol efflux (GO:0033344)3.32586625
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31130041
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.24287086
75regulation of gamma-delta T cell activation (GO:0046643)3.23855026
76T-helper 1 type immune response (GO:0042088)3.23220923
77regulation of vitamin metabolic process (GO:0030656)3.22261832
78negative regulation of interleukin-6 production (GO:0032715)3.21898293
79immunoglobulin mediated immune response (GO:0016064)3.20444502
80regulation of interferon-beta biosynthetic process (GO:0045357)3.19335291
81neutrophil activation involved in immune response (GO:0002283)3.19311564
82opsonization (GO:0008228)3.18402238
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17620925
84cellular extravasation (GO:0045123)3.17257562
85protein-lipid complex remodeling (GO:0034368)3.13883508
86macromolecular complex remodeling (GO:0034367)3.13883508
87plasma lipoprotein particle remodeling (GO:0034369)3.13883508
88positive regulation of NF-kappaB import into nucleus (GO:0042346)3.13866415
89bile acid and bile salt transport (GO:0015721)3.13501889
90cholesterol homeostasis (GO:0042632)3.12564430
91sterol homeostasis (GO:0055092)3.10377831
92leukocyte aggregation (GO:0070486)3.09882424
93negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08115073
94granulocyte activation (GO:0036230)3.06954017
95response to type I interferon (GO:0034340)3.05216438
96amine catabolic process (GO:0009310)3.03435682
97cellular biogenic amine catabolic process (GO:0042402)3.03435682
98intestinal cholesterol absorption (GO:0030299)3.03268759
99cofactor catabolic process (GO:0051187)3.02957402
100regulation of interleukin-2 biosynthetic process (GO:0045076)3.02175054
101type I interferon signaling pathway (GO:0060337)3.01888815
102cellular response to type I interferon (GO:0071357)3.01888815
103low-density lipoprotein particle clearance (GO:0034383)3.01806037
104regulation of bile acid biosynthetic process (GO:0070857)2.99203225
105regulation of fever generation (GO:0031620)2.98882827
106positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98064713
107negative regulation of T cell mediated immunity (GO:0002710)2.97189223
108myeloid dendritic cell activation (GO:0001773)2.96419808
109homocysteine metabolic process (GO:0050667)2.96082545
110heme transport (GO:0015886)2.95930643
111negative regulation of lipase activity (GO:0060192)2.94368568
112indolalkylamine metabolic process (GO:0006586)2.93139554
113lipoprotein metabolic process (GO:0042157)2.93007598
114sulfur amino acid catabolic process (GO:0000098)2.92297406
115regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92189310
116cholesterol biosynthetic process (GO:0006695)2.91883633
117regulation of cytokine secretion involved in immune response (GO:0002739)2.90122848
118coenzyme catabolic process (GO:0009109)2.90022526
119plasma lipoprotein particle assembly (GO:0034377)2.88578100
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87276195
121regulation of T cell tolerance induction (GO:0002664)2.85203500
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.85058076
123myeloid cell activation involved in immune response (GO:0002275)2.84846435
124cellular glucuronidation (GO:0052695)2.84465066
125regulation of T-helper 2 cell differentiation (GO:0045628)2.84091868
126regulation of interleukin-8 biosynthetic process (GO:0045414)2.83205256
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82235914
128negative regulation of interleukin-1 beta production (GO:0032691)2.81430947
129regulation of interferon-alpha production (GO:0032647)2.81382782
130regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81160846
131protein-lipid complex assembly (GO:0065005)2.80561687
132macrophage activation (GO:0042116)2.80480052
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79649772
134positive regulation of interleukin-2 production (GO:0032743)2.79598186
135regulation of podosome assembly (GO:0071801)2.79331661
136blood coagulation, intrinsic pathway (GO:0007597)2.79068864
137neutrophil activation (GO:0042119)2.78741301
138very long-chain fatty acid metabolic process (GO:0000038)2.78098058
139protein activation cascade (GO:0072376)2.77093481
140interferon-gamma production (GO:0032609)2.76673867
141T-helper cell differentiation (GO:0042093)2.76359240
142CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.76359240
143negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75962908
144regulation of interleukin-12 production (GO:0032655)2.75934200
145regulation of interleukin-6 production (GO:0032675)2.75499552
146interferon-gamma-mediated signaling pathway (GO:0060333)2.75477105
147detection of molecule of bacterial origin (GO:0032490)2.74969881
148positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73196329
149amino-acid betaine metabolic process (GO:0006577)2.72790678
150negative regulation of production of molecular mediator of immune response (GO:0002701)2.72435922
151serine family amino acid catabolic process (GO:0009071)2.72260008
152negative regulation of tumor necrosis factor production (GO:0032720)2.71738775
153positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71546897
154negative regulation of lipid storage (GO:0010888)2.71414468
155negative regulation of interleukin-1 production (GO:0032692)2.70971261
156cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.70894292
157amyloid precursor protein catabolic process (GO:0042987)2.70710533
158regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69551393
159negative regulation of innate immune response (GO:0045824)2.69230175
160negative regulation of hemostasis (GO:1900047)2.68253461
161negative regulation of blood coagulation (GO:0030195)2.68253461
162response to laminar fluid shear stress (GO:0034616)2.67274158
163phospholipid homeostasis (GO:0055091)2.66830694
164glutamate metabolic process (GO:0006536)2.65560115
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65073843
166alpha-amino acid catabolic process (GO:1901606)2.65067669
167regulation of NF-kappaB import into nucleus (GO:0042345)2.64594181
168negative regulation of T-helper cell differentiation (GO:0045623)2.64038463
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64038463
170response to nitrosative stress (GO:0051409)2.63777068
171negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.63342883
172regulation of heterotypic cell-cell adhesion (GO:0034114)2.62650483
173detection of other organism (GO:0098543)2.62563849
174response to host immune response (GO:0052572)2.62120112
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62120112
176regulation of tolerance induction (GO:0002643)2.62094219
177positive regulation of antigen processing and presentation (GO:0002579)2.62078166
178positive regulation of triglyceride metabolic process (GO:0090208)2.61788036
179very-low-density lipoprotein particle assembly (GO:0034379)2.60605716
180complement activation (GO:0006956)2.60266828
181antigen processing and presentation of endogenous antigen (GO:0019883)2.59915805
182positive regulation of lipid catabolic process (GO:0050996)2.59645900
183positive regulation of fatty acid biosynthetic process (GO:0045723)2.59625426
184sterol biosynthetic process (GO:0016126)2.59585378
185positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59374642
186positive regulation of isotype switching (GO:0045830)2.59239729
187positive regulation of tolerance induction (GO:0002645)2.59130058
188lipid homeostasis (GO:0055088)2.57916147
189T cell migration (GO:0072678)2.57483890
190regulation of plasminogen activation (GO:0010755)2.57269114
191positive regulation of B cell mediated immunity (GO:0002714)2.57083541
192positive regulation of immunoglobulin mediated immune response (GO:0002891)2.57083541
193aldehyde catabolic process (GO:0046185)2.56945999
194regulation of regulatory T cell differentiation (GO:0045589)2.56667348
195positive regulation of toll-like receptor signaling pathway (GO:0034123)2.56612116
196positive regulation of type 2 immune response (GO:0002830)2.56058327
197glucuronate metabolic process (GO:0019585)2.55436305
198uronic acid metabolic process (GO:0006063)2.55436305
199fatty-acyl-CoA biosynthetic process (GO:0046949)2.54616946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.19573130
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.42753354
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.62134326
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.52609590
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.73326059
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.67278606
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05767284
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92565728
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92214702
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.72071963
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50200026
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.48608058
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42633416
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42094592
15VDR_21846776_ChIP-Seq_THP-1_Human2.31204733
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21335644
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17399031
18CLOCK_20551151_ChIP-Seq_293T_Human2.16724734
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15705066
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09741444
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.02307634
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99309660
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97018494
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93860253
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92804851
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89026244
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.84665532
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.84658406
29MYB_26560356_Chip-Seq_TH2_Human1.84602962
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82931063
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82029481
32SCL_19346495_ChIP-Seq_HPC-7_Human1.76231203
33SPI1_23547873_ChIP-Seq_NB4_Human1.68462733
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68109276
35SPI1_23127762_ChIP-Seq_K562_Human1.67000139
36UTX_26944678_Chip-Seq_JUKART_Human1.65054965
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63148552
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60821593
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.57430955
40RUNX_20019798_ChIP-Seq_JUKART_Human1.56285728
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55041954
42MYC_22102868_ChIP-Seq_BL_Human1.54534813
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.54483199
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.52348574
45* MAF_26560356_Chip-Seq_TH2_Human1.50425435
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.48296128
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47404134
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.46663275
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42499993
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40039198
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.36187159
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36087478
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32670415
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30716325
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30005433
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29993575
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28696380
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.28656636
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28535841
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27263803
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26787876
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23584883
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23072742
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22166787
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21505880
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.20735525
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.20146544
68GATA3_26560356_Chip-Seq_TH2_Human1.20083103
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19176916
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18901220
71* PU_27001747_Chip-Seq_BMDM_Mouse1.18523838
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.16354567
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15920565
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15698649
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14904391
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.14644615
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13255798
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.13113206
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.12240452
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12097118
81* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12072576
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11961615
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10971201
84* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10950506
85ZNF263_19887448_ChIP-Seq_K562_Human1.07468278
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07433598
87SOX2_20726797_ChIP-Seq_SW620_Human1.07192381
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07068463
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.05507077
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05015316
91VDR_24787735_ChIP-Seq_THP-1_Human1.04451007
92BCL6_27268052_Chip-Seq_Bcells_Human1.04261809
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03670658
94MAF_26560356_Chip-Seq_TH1_Human1.03574295
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03456373
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02982197
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02643675
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02539000
99BCOR_27268052_Chip-Seq_Bcells_Human1.01949764
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01782996
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01411396
102* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00842012
103GATA1_19941826_ChIP-Seq_K562_Human0.97696971
104VDR_24763502_ChIP-Seq_THP-1_Human0.97599277
105EGR1_19032775_ChIP-ChIP_M12_Human0.96992510
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95436265
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93067608
108* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91752313
109GATA4_25053715_ChIP-Seq_YYC3_Human0.91520313
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91476891
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91224107
112* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90757422
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90196131
114* KDM2B_26808549_Chip-Seq_K562_Human0.90077378
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.89570531
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89532172
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88901816
118TCF7_22412390_ChIP-Seq_EML_Mouse0.88855283
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88606745
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88526807
121* ATF3_27146783_Chip-Seq_COLON_Human0.88204184
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87843873
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87535821
124* KDM2B_26808549_Chip-Seq_DND41_Human0.87321286
125* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86743348
126CJUN_26792858_Chip-Seq_BT549_Human0.86663981
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85127097
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84820763
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84230932
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83819628
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.82761555
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82741310
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82741310
134LXR_22292898_ChIP-Seq_THP-1_Human0.82491460
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.81296173
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80733538
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80733538
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80733538
139MYB_26560356_Chip-Seq_TH1_Human0.80660018
140GATA2_19941826_ChIP-Seq_K562_Human0.80128322
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79367041
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78317757
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78317757
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76598119
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.76136982
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76046994
147* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75852514
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75527972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.57647879
2MP0005360_urolithiasis4.75170246
3MP0005085_abnormal_gallbladder_physiolo4.38050764
4MP0005365_abnormal_bile_salt4.08754352
5MP0009840_abnormal_foam_cell3.68956646
6MP0008875_abnormal_xenobiotic_pharmacok3.43289282
7MP0003252_abnormal_bile_duct3.13045833
8MP0003806_abnormal_nucleotide_metabolis2.85698332
9MP0003724_increased_susceptibility_to2.49245582
10MP0003191_abnormal_cellular_cholesterol2.40904538
11MP0009278_abnormal_bone_marrow2.25171469
12MP0010329_abnormal_lipoprotein_level2.23402129
13MP0002138_abnormal_hepatobiliary_system2.08042462
14MP0003436_decreased_susceptibility_to2.06074249
15MP0005083_abnormal_biliary_tract2.04527618
16MP0003303_peritoneal_inflammation2.04252879
17MP0005451_abnormal_body_composition2.01271448
18MP0003195_calcinosis2.00260172
19MP0005167_abnormal_blood-brain_barrier1.99033387
20MP0000609_abnormal_liver_physiology1.92436388
21MP0006082_CNS_inflammation1.85706840
22MP0003300_gastrointestinal_ulcer1.80083647
23MP0004947_skin_inflammation1.79209852
24MP0003172_abnormal_lysosome_physiology1.76899179
25MP0001666_abnormal_nutrient_absorption1.76830358
26MP0001851_eye_inflammation1.74962436
27MP0005332_abnormal_amino_acid1.68889500
28MP0002118_abnormal_lipid_homeostasis1.68151743
29MP0004381_abnormal_hair_follicle1.60643889
30MP0005387_immune_system_phenotype1.58785403
31MP0001790_abnormal_immune_system1.58785403
32MP0003705_abnormal_hypodermis_morpholog1.58058478
33MP0003453_abnormal_keratinocyte_physiol1.57064519
34MP0001873_stomach_inflammation1.55280634
35MP0000716_abnormal_immune_system1.53751972
36MP0005310_abnormal_salivary_gland1.50684768
37MP0000920_abnormal_myelination1.49549121
38MP0003828_pulmonary_edema1.49474932
39MP0002419_abnormal_innate_immunity1.45635826
40MP0005000_abnormal_immune_tolerance1.45286928
41MP0004019_abnormal_vitamin_homeostasis1.43627218
42MP0005397_hematopoietic_system_phenotyp1.41093512
43MP0001545_abnormal_hematopoietic_system1.41093512
44MP0003690_abnormal_glial_cell1.40572092
45MP0000604_amyloidosis1.38737827
46MP0008004_abnormal_stomach_pH1.37418012
47MP0002398_abnormal_bone_marrow1.34829185
48MP0008961_abnormal_basal_metabolism1.27141682
49MP0004510_myositis1.26489525
50MP0010368_abnormal_lymphatic_system1.25520543
51MP0008469_abnormal_protein_level1.25128768
52MP0001533_abnormal_skeleton_physiology1.24637732
53MP0000858_altered_metastatic_potential1.24508883
54MP0002933_joint_inflammation1.23335009
55MP0002723_abnormal_immune_serum1.23076332
56MP0003868_abnormal_feces_composition1.19558372
57MP0005025_abnormal_response_to1.18228106
58MP0001800_abnormal_humoral_immune1.18198376
59MP0000689_abnormal_spleen_morphology1.15582681
60MP0002429_abnormal_blood_cell1.15348857
61MP0009785_altered_susceptibility_to1.14997392
62MP0002254_reproductive_system_inflammat1.14679766
63MP0002796_impaired_skin_barrier1.14172057
64MP0001501_abnormal_sleep_pattern1.14069091
65MP0001243_abnormal_dermal_layer1.12579498
66MP0005319_abnormal_enzyme/_coenzyme1.12231043
67MP0001853_heart_inflammation1.12114399
68MP0006054_spinal_hemorrhage1.12090329
69MP0010234_abnormal_vibrissa_follicle1.11173476
70MP0002332_abnormal_exercise_endurance1.09731373
71MP0001845_abnormal_inflammatory_respons1.09207344
72MP0002722_abnormal_immune_system1.08254893
73MP0000465_gastrointestinal_hemorrhage1.06711472
74MP0002277_abnormal_respiratory_mucosa1.06105162
75* MP0003448_altered_tumor_morphology1.06032281
76MP0009763_increased_sensitivity_to1.05609190
77MP0002405_respiratory_system_inflammati1.05133444
78MP0005058_abnormal_lysosome_morphology1.03858889
79MP0005464_abnormal_platelet_physiology1.03627725
80MP0002452_abnormal_antigen_presenting1.02145901
81MP0004883_abnormal_blood_vessel1.00616796
82MP0008260_abnormal_autophagy0.99962163
83MP0009333_abnormal_splenocyte_physiolog0.99617396
84MP0002998_abnormal_bone_remodeling0.99533997
85MP0000598_abnormal_liver_morphology0.99140872
86MP0001663_abnormal_digestive_system0.98753666
87MP0000685_abnormal_immune_system0.98494740
88MP0009643_abnormal_urine_homeostasis0.98342897
89MP0003329_amyloid_beta_deposits0.97346417
90MP0005166_decreased_susceptibility_to0.97079793
91MP0003091_abnormal_cell_migration0.96751051
92MP0005584_abnormal_enzyme/coenzyme_acti0.95138226
93MP0002148_abnormal_hypersensitivity_rea0.95137831
94MP0005023_abnormal_wound_healing0.94803482
95MP0005671_abnormal_response_to0.93811710
96MP0003075_altered_response_to0.92875228
97MP0002060_abnormal_skin_morphology0.92487605
98MP0003656_abnormal_erythrocyte_physiolo0.90750698
99MP0001835_abnormal_antigen_presentation0.90345749
100MP0003866_abnormal_defecation0.89750373
101MP0009764_decreased_sensitivity_to0.87865708
102MP0003279_aneurysm0.86389474
103MP0001819_abnormal_immune_cell0.86061542
104MP0002420_abnormal_adaptive_immunity0.85871083
105MP0005670_abnormal_white_adipose0.85399009
106MP0003646_muscle_fatigue0.84911733
107MP0010678_abnormal_skin_adnexa0.84281290
108MP0000249_abnormal_blood_vessel0.83165079
109MP0001216_abnormal_epidermal_layer0.83158926
110MP0010155_abnormal_intestine_physiology0.83005023
111MP0003045_fibrosis0.82899424
112MP0003763_abnormal_thymus_physiology0.81395999
113MP0000703_abnormal_thymus_morphology0.79680687
114MP0008873_increased_physiological_sensi0.79514597
115MP0003795_abnormal_bone_structure0.76977575
116MP0005164_abnormal_response_to0.75982135
117MP0001881_abnormal_mammary_gland0.75483772
118MP0001542_abnormal_bone_strength0.75152604
119MP0000579_abnormal_nail_morphology0.74561763
120MP0004185_abnormal_adipocyte_glucose0.73451682
121MP0003186_abnormal_redox_activity0.72886919
122MP0009053_abnormal_anal_canal0.72217681
123MP0004808_abnormal_hematopoietic_stem0.71589111
124MP0009765_abnormal_xenobiotic_induced0.70003779
125MP0000647_abnormal_sebaceous_gland0.69670852
126MP0005076_abnormal_cell_differentiation0.69328798
127MP0005390_skeleton_phenotype0.68773122
128MP0005408_hypopigmentation0.68340970
129MP0001661_extended_life_span0.68182566
130MP0003566_abnormal_cell_adhesion0.67013692
131MP0000343_altered_response_to0.65903363
132MP0004264_abnormal_extraembryonic_tissu0.65573431
133MP0002098_abnormal_vibrissa_morphology0.65253220
134MP0009642_abnormal_blood_homeostasis0.64152725
135MP0002132_abnormal_respiratory_system0.56301397
136MP0005381_digestive/alimentary_phenotyp0.54509743
137MP0008874_decreased_physiological_sensi0.53507304
138MP0002877_abnormal_melanocyte_morpholog0.52296906
139MP0002006_tumorigenesis0.51261381
140MP0003183_abnormal_peptide_metabolism0.50480671
141MP0002653_abnormal_ependyma_morphology0.48999803
142MP0005535_abnormal_body_temperature0.48723834

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.07916828
2Intrahepatic cholestasis (HP:0001406)5.96545710
3Deep venous thrombosis (HP:0002625)5.77182616
4Abnormality of glycolipid metabolism (HP:0010969)5.58978021
5Abnormality of liposaccharide metabolism (HP:0010968)5.58978021
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.58978021
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.34425961
8Prolonged partial thromboplastin time (HP:0003645)5.29786067
9Xanthomatosis (HP:0000991)5.25379724
10Joint hemorrhage (HP:0005261)5.00911212
11Myositis (HP:0100614)4.83982459
12Optic neuritis (HP:0100653)4.79176551
13Retrobulbar optic neuritis (HP:0100654)4.79176551
14Orchitis (HP:0100796)4.75647243
15Abnormality of macrophages (HP:0004311)4.74734429
16Complement deficiency (HP:0004431)4.30679678
17Hypobetalipoproteinemia (HP:0003563)4.27676160
18Hyperlipoproteinemia (HP:0010980)4.24272115
19Recurrent abscess formation (HP:0002722)3.92949617
20Mediastinal lymphadenopathy (HP:0100721)3.86495086
21Autoimmune thrombocytopenia (HP:0001973)3.86112511
22Increased cerebral lipofuscin (HP:0011813)3.78751532
23Myocardial infarction (HP:0001658)3.70847220
24Abnormality of the common coagulation pathway (HP:0010990)3.64929225
25Epidermoid cyst (HP:0200040)3.62420159
26Stomatitis (HP:0010280)3.50459931
27Loss of speech (HP:0002371)3.48670040
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43692764
29Keratoconjunctivitis sicca (HP:0001097)3.40966870
30Abnormality of complement system (HP:0005339)3.36268514
31Fat malabsorption (HP:0002630)3.33969005
32Keratoconjunctivitis (HP:0001096)3.32729160
33Conjugated hyperbilirubinemia (HP:0002908)3.27618959
34Hypolipoproteinemia (HP:0010981)3.26597838
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.26519297
36Pulmonary infiltrates (HP:0002113)3.25635948
37Recurrent gram-negative bacterial infections (HP:0005420)3.22831643
38Pustule (HP:0200039)3.18332583
39Parakeratosis (HP:0001036)3.16666676
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.16558733
41Eczematoid dermatitis (HP:0000976)3.14295948
42Systemic lupus erythematosus (HP:0002725)3.13923615
43Vasculitis (HP:0002633)3.11816523
44Hypoalphalipoproteinemia (HP:0003233)3.04661500
45Abnormality of mucopolysaccharide metabolism (HP:0011020)3.03590258
46Abnormality of polysaccharide metabolism (HP:0011012)3.03590258
47Abnormality of glycosaminoglycan metabolism (HP:0004371)3.03590258
48Abnormality of the intrinsic pathway (HP:0010989)2.96528968
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.95786467
50Hemoptysis (HP:0002105)2.89501733
51Hematochezia (HP:0002573)2.89480204
52Abnormality of methionine metabolism (HP:0010901)2.86200348
53Increased IgE level (HP:0003212)2.80827463
54Interstitial pulmonary disease (HP:0006530)2.79322192
55Gingival bleeding (HP:0000225)2.78718791
56Urinary glycosaminoglycan excretion (HP:0003541)2.74945089
57Mucopolysacchariduria (HP:0008155)2.74945089
58Amyloidosis (HP:0011034)2.73579293
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69820670
60Neurofibrillary tangles (HP:0002185)2.69301030
61Steatorrhea (HP:0002570)2.67044687
62Increased IgM level (HP:0003496)2.64964093
63Vascular calcification (HP:0004934)2.62335351
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59279875
65Glomerulonephritis (HP:0000099)2.58189544
66Autoimmune hemolytic anemia (HP:0001890)2.57558722
67Menorrhagia (HP:0000132)2.57344192
68Hypoglycemic seizures (HP:0002173)2.54644103
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.53458147
70Leukocytosis (HP:0001974)2.53250705
71Axonal loss (HP:0003447)2.52098671
72Recurrent cutaneous fungal infections (HP:0011370)2.51253676
73Chronic mucocutaneous candidiasis (HP:0002728)2.51253676
74Recurrent viral infections (HP:0004429)2.50333689
75T lymphocytopenia (HP:0005403)2.49186999
76Gastrointestinal infarctions (HP:0005244)2.47929956
77Spontaneous abortion (HP:0005268)2.46802358
78Hyperammonemia (HP:0001987)2.46660486
79Segmental peripheral demyelination/remyelination (HP:0003481)2.45919154
80Abnormality of T cell number (HP:0011839)2.45791345
81Obstructive lung disease (HP:0006536)2.45282320
82Chronic obstructive pulmonary disease (HP:0006510)2.45282320
83Gangrene (HP:0100758)2.44865849
84Peripheral demyelination (HP:0011096)2.43958259
85Abnormality of pyrimidine metabolism (HP:0004353)2.39726028
86Meningitis (HP:0001287)2.37763220
87Disinhibition (HP:0000734)2.36450167
88Esophageal varix (HP:0002040)2.35500227
89Hypoglycemic coma (HP:0001325)2.34869254
90Abnormality of iron homeostasis (HP:0011031)2.34356342
91Hypercholesterolemia (HP:0003124)2.33557268
92Hypergammaglobulinemia (HP:0010702)2.31607130
93Increased serum ferritin (HP:0003281)2.30738000
94Mutism (HP:0002300)2.29866980
95Cardiovascular calcification (HP:0011915)2.27387079
96Peripheral hypomyelination (HP:0007182)2.26372779
97Keratitis (HP:0000491)2.24497107
98Ketosis (HP:0001946)2.22656359
99Pulmonary embolism (HP:0002204)2.19627945
100Encephalitis (HP:0002383)2.17851166
101Urticaria (HP:0001025)2.15671816
102Recurrent bacterial skin infections (HP:0005406)2.15359436
103Anorexia (HP:0002039)2.13753035
104Polyneuropathy (HP:0001271)2.12619370
105Hypophosphatemic rickets (HP:0004912)2.12269267
106Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10230273
107Gingivitis (HP:0000230)2.09181875
108Abnormal tarsal ossification (HP:0008369)2.08198875
109Hydroxyprolinuria (HP:0003080)2.07766040
110Abnormality of proline metabolism (HP:0010907)2.07766040
111Cerebral inclusion bodies (HP:0100314)2.07181483
112Spontaneous hematomas (HP:0007420)2.06714145
113Abnormality of transition element cation homeostasis (HP:0011030)2.06334917
114Pancreatitis (HP:0001733)2.04407889
115Vacuolated lymphocytes (HP:0001922)2.02393500
116Hemorrhage of the eye (HP:0011885)2.00625287
117Skin nodule (HP:0200036)1.98960115
118Symptomatic seizures (HP:0011145)1.98504748
119Disproportionate tall stature (HP:0001519)1.98055747
120Mitral stenosis (HP:0001718)1.97653170
121Stomach cancer (HP:0012126)1.96426106
122Abnormality of the pericardium (HP:0001697)1.96004484
123Abnormality of nucleobase metabolism (HP:0010932)1.95893602
124Arterial thrombosis (HP:0004420)1.95042335
125Spondylolisthesis (HP:0003302)1.94952933
126Recurrent skin infections (HP:0001581)1.94435263
127Abnormality of the pleura (HP:0002103)1.94411932
128Onion bulb formation (HP:0003383)1.93930949
129Restrictive lung disease (HP:0002091)1.93748111
130Eosinophilia (HP:0001880)1.93210791
131Abnormal enzyme/coenzyme activity (HP:0012379)1.93034192
132Abnormality of T cells (HP:0002843)1.92038381
133Arthralgia (HP:0002829)1.91350123
134Joint swelling (HP:0001386)1.90760470
135Neuronal loss in central nervous system (HP:0002529)1.90578264
136Lymphopenia (HP:0001888)1.89375064
137Elevated alkaline phosphatase (HP:0003155)1.89008087
138Alveolar cell carcinoma (HP:0006519)1.88996226
139Slow saccadic eye movements (HP:0000514)1.88212341
140Gastrointestinal stroma tumor (HP:0100723)1.88061854
141Progressive neurologic deterioration (HP:0002344)1.87783201
142Thrombophlebitis (HP:0004418)1.87771236
143Abnormal gallbladder morphology (HP:0012437)1.87519959
144Peritonitis (HP:0002586)1.87248507
145Granulocytopenia (HP:0001913)1.86127255
146Hyperbilirubinemia (HP:0002904)1.85336020
147Ileus (HP:0002595)1.84992622
148Paraparesis (HP:0002385)1.84505248
149Rickets (HP:0002748)1.84046378
150Petechiae (HP:0000967)1.83586856
151Vertigo (HP:0002321)1.81512790
152Glomerulopathy (HP:0100820)1.81082225
153Hepatocellular carcinoma (HP:0001402)1.81037511
154Purpura (HP:0000979)1.80746419
155Abnormality of the endocardium (HP:0004306)1.80639195
156Spastic paraparesis (HP:0002313)1.80555968
157Increased CSF protein (HP:0002922)1.79750988
158Thick nail (HP:0001805)1.79544638
159Abnormality of alkaline phosphatase activity (HP:0004379)1.79538278
160Elevated erythrocyte sedimentation rate (HP:0003565)1.79264686
161Protuberant abdomen (HP:0001538)1.79133554
162Erythroderma (HP:0001019)1.78559311
163Congenital ichthyosiform erythroderma (HP:0007431)1.78433728
164Anhidrosis (HP:0000970)1.78246262
165Irritability (HP:0000737)1.77830951
166Dysostosis multiplex (HP:0000943)1.77663728
167Sensorimotor neuropathy (HP:0007141)1.77147323
168Albinism (HP:0001022)1.76067751
169Abnormality of fatty-acid metabolism (HP:0004359)1.75258066
170Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75197955
171Abnormality of glycine metabolism (HP:0010895)1.75192345
172Abnormality of serine family amino acid metabolism (HP:0010894)1.75192345
173Abnormality of eosinophils (HP:0001879)1.75185904
174Nuclear cataract (HP:0100018)1.75062905
175Recurrent fungal infections (HP:0002841)1.74633161
176Abnormal cartilage morphology (HP:0002763)1.74478467
177Abnormality of purine metabolism (HP:0004352)1.73977389
178Autoamputation (HP:0001218)1.72648294
179Increased mean platelet volume (HP:0011877)1.71470781
180Hyperglycinemia (HP:0002154)1.71035961
181Episodic fever (HP:0001954)1.69036007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.89303637
2MAP3K143.35295589
3ERN13.27952919
4MAP4K13.10923096
5MAPK153.03171949
6FGFR42.96170715
7EPHA32.56612425
8TXK2.13574240
9PRPF4B2.07272549
10ITK2.06438488
11MAP3K32.05420762
12GRK71.96945497
13STK391.92760872
14EPHA21.91774995
15TBK11.86455742
16TAOK21.85907881
17ADRBK21.85327546
18RIPK41.84086916
19TSSK61.83544728
20MET1.72084489
21PBK1.70669049
22ERBB41.67935482
23TGFBR21.64598997
24CSK1.57612230
25MATK1.57267286
26STK101.50035124
27IRAK31.48155204
28IKBKB1.47033383
29TYK21.44405708
30SIK31.44053735
31ZAP701.43811856
32NLK1.43326034
33MAP2K21.37291405
34MAPK71.34471650
35MAP2K31.33675683
36TAOK31.31665446
37IKBKE1.21017179
38CDK121.20931397
39GSK3A1.20513156
40CHUK1.20439909
41DDR21.15740660
42TESK21.14990044
43MARK31.14882929
44CDC42BPA1.14667796
45SIK11.14004397
46SIK21.13421246
47MOS1.12989980
48IRAK11.11520308
49SYK1.11187044
50MAPKAPK51.10631285
51JAK11.10613493
52PTK61.09987881
53FES1.09439907
54KDR1.09023807
55OXSR11.05811657
56IRAK21.05731776
57MST41.05326354
58RPS6KA41.04904168
59NME21.03831913
60BLK1.00149042
61LYN0.99003244
62KIT0.97451788
63CAMKK20.97081083
64CSF1R0.96934408
65BCKDK0.96210793
66BMPR20.94293884
67JAK20.93980621
68JAK30.93978592
69BCR0.92557697
70CSNK1A1L0.92032723
71TRPM70.91940347
72PKN10.90574307
73FGR0.90243701
74TNK20.89918349
75FGFR20.88069943
76MAP3K110.87899004
77MARK20.85738027
78TAOK10.85159627
79PRKCQ0.83321309
80ABL20.81044865
81GRK60.79290926
82PRKD20.76301072
83MAP3K130.75107784
84PTK20.74729154
85MAP3K10.74305108
86HCK0.73917276
87WNK40.73850107
88EPHB20.73039479
89LCK0.72790368
90BMX0.72482485
91TRIB30.71401957
92NEK60.67063851
93CAMKK10.66721096
94RPS6KA60.65877709
95HIPK20.65074140
96MAP3K50.64931214
97IRAK40.64769114
98FGFR30.64208591
99RPS6KC10.63211765
100RPS6KL10.63211765
101PRKCH0.62277752
102MAPK40.61229612
103INSRR0.60998404
104CSNK1G10.59378873
105DYRK1B0.58829350
106STK240.58156970
107RPS6KA50.56906265
108MTOR0.56629246
109MAP2K60.56627742
110CSNK1G30.55297857
111TLK10.50526530
112CLK10.49588780
113ERBB20.49261923
114MAPK120.49114408
115MST1R0.48743977
116PDGFRB0.47426881
117ICK0.46000129
118CAMK40.45795812
119ABL10.45686813
120MELK0.44992915
121EGFR0.44335935
122PDK10.43791405
123PIM10.43425003
124LIMK10.43253701
125INSR0.41650667
126TYRO30.40538934
127RPS6KA20.39900601
128MAPKAPK20.39505722
129BRD40.39173058
130TEC0.38969944
131RIPK10.38244806
132MAP3K70.38160103
133CAMK2G0.37839117
134PAK20.37498643
135WNK10.37230507
136BTK0.36043930
137MAP2K10.36001195
138DAPK20.35929341
139PRKD10.35344937
140PIM20.35082506
141NTRK10.34715234
142RPS6KA10.30419983
143PDPK10.30083143
144DYRK30.28621883
145GRK10.28469291

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90380930
2Complement and coagulation cascades_Homo sapiens_hsa046103.07573429
3Nitrogen metabolism_Homo sapiens_hsa009102.88939311
4Staphylococcus aureus infection_Homo sapiens_hsa051502.66279942
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57491670
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49250047
7Steroid biosynthesis_Homo sapiens_hsa001002.48996904
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47645128
9Arginine biosynthesis_Homo sapiens_hsa002202.39900654
10Tryptophan metabolism_Homo sapiens_hsa003802.26758112
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25496378
12Histidine metabolism_Homo sapiens_hsa003402.20677794
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87129578
14Fatty acid elongation_Homo sapiens_hsa000621.85161118
15* Tuberculosis_Homo sapiens_hsa051521.76890548
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.63838194
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.61842312
18Peroxisome_Homo sapiens_hsa041461.61152505
19Butanoate metabolism_Homo sapiens_hsa006501.61135003
20Toxoplasmosis_Homo sapiens_hsa051451.59953611
21Chemical carcinogenesis_Homo sapiens_hsa052041.59234279
22Influenza A_Homo sapiens_hsa051641.58895366
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58592113
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.57445305
25PPAR signaling pathway_Homo sapiens_hsa033201.55435788
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52708586
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52238606
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51515967
29Fatty acid degradation_Homo sapiens_hsa000711.49127017
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48682296
31Type I diabetes mellitus_Homo sapiens_hsa049401.47938712
32African trypanosomiasis_Homo sapiens_hsa051431.45566437
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43567804
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41811112
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37611168
36Sulfur metabolism_Homo sapiens_hsa009201.33237500
37Herpes simplex infection_Homo sapiens_hsa051681.32168203
38Caffeine metabolism_Homo sapiens_hsa002321.31764123
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30429361
40Retinol metabolism_Homo sapiens_hsa008301.30341131
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30049595
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28674620
43Selenocompound metabolism_Homo sapiens_hsa004501.28327212
44Chemokine signaling pathway_Homo sapiens_hsa040621.26152778
45Hepatitis B_Homo sapiens_hsa051611.25670901
46Fatty acid metabolism_Homo sapiens_hsa012121.23652354
47Folate biosynthesis_Homo sapiens_hsa007901.20168771
48ABC transporters_Homo sapiens_hsa020101.18929177
49Bile secretion_Homo sapiens_hsa049761.16077692
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.13563209
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13303453
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10192216
53Phenylalanine metabolism_Homo sapiens_hsa003601.09952968
54Graft-versus-host disease_Homo sapiens_hsa053321.08394166
55Prion diseases_Homo sapiens_hsa050201.08252279
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07041618
57Arginine and proline metabolism_Homo sapiens_hsa003301.06079280
58Fat digestion and absorption_Homo sapiens_hsa049751.05669514
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05379315
60Apoptosis_Homo sapiens_hsa042101.04760394
61Osteoclast differentiation_Homo sapiens_hsa043801.02387200
62Starch and sucrose metabolism_Homo sapiens_hsa005001.01888267
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.01859957
64beta-Alanine metabolism_Homo sapiens_hsa004101.00750893
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99903239
66Viral myocarditis_Homo sapiens_hsa054160.96057078
67Vitamin digestion and absorption_Homo sapiens_hsa049770.93159899
68Tyrosine metabolism_Homo sapiens_hsa003500.90899252
69Prolactin signaling pathway_Homo sapiens_hsa049170.89047925
70T cell receptor signaling pathway_Homo sapiens_hsa046600.88336825
71Malaria_Homo sapiens_hsa051440.83874230
72VEGF signaling pathway_Homo sapiens_hsa043700.81737582
73Epstein-Barr virus infection_Homo sapiens_hsa051690.80769723
74Bladder cancer_Homo sapiens_hsa052190.79164613
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79125439
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.78715457
77Amoebiasis_Homo sapiens_hsa051460.77935543
78Leishmaniasis_Homo sapiens_hsa051400.77215472
79Propanoate metabolism_Homo sapiens_hsa006400.75635491
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71636778
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71346000
82MAPK signaling pathway_Homo sapiens_hsa040100.71080551
83Lysosome_Homo sapiens_hsa041420.70522210
84Rheumatoid arthritis_Homo sapiens_hsa053230.69613731
85Lysine degradation_Homo sapiens_hsa003100.68909472
86TNF signaling pathway_Homo sapiens_hsa046680.68079054
87Notch signaling pathway_Homo sapiens_hsa043300.66938387
88Asthma_Homo sapiens_hsa053100.66172501
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65954867
90Pertussis_Homo sapiens_hsa051330.64633932
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61817463
92Allograft rejection_Homo sapiens_hsa053300.61788923
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.60276009
94Type II diabetes mellitus_Homo sapiens_hsa049300.60132612
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.59598387
96Glutathione metabolism_Homo sapiens_hsa004800.59283288
97Viral carcinogenesis_Homo sapiens_hsa052030.58183764
98Collecting duct acid secretion_Homo sapiens_hsa049660.56820693
99HTLV-I infection_Homo sapiens_hsa051660.56786155
100Chronic myeloid leukemia_Homo sapiens_hsa052200.56744404
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55705656
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55560081
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55497514
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54119897
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.52088027
106* FoxO signaling pathway_Homo sapiens_hsa040680.52062411
107Hepatitis C_Homo sapiens_hsa051600.51505109
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51462463
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.51162148
110Autoimmune thyroid disease_Homo sapiens_hsa053200.51015568
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50429308
112Ether lipid metabolism_Homo sapiens_hsa005650.50147518
113Measles_Homo sapiens_hsa051620.49912729
114Hematopoietic cell lineage_Homo sapiens_hsa046400.49491808
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49374309
116Insulin resistance_Homo sapiens_hsa049310.49268279
117Vitamin B6 metabolism_Homo sapiens_hsa007500.48069734
118Legionellosis_Homo sapiens_hsa051340.48022499
119Renal cell carcinoma_Homo sapiens_hsa052110.47413198
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47146371
121Platelet activation_Homo sapiens_hsa046110.46448228
122B cell receptor signaling pathway_Homo sapiens_hsa046620.46036630
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.45098652
124Pancreatic cancer_Homo sapiens_hsa052120.45092077
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43753511
126Sphingolipid metabolism_Homo sapiens_hsa006000.43388732
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41794626
128GnRH signaling pathway_Homo sapiens_hsa049120.41572474
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41410429
130HIF-1 signaling pathway_Homo sapiens_hsa040660.40984564
131Salmonella infection_Homo sapiens_hsa051320.40710685
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40613828
133Endocytosis_Homo sapiens_hsa041440.40487381
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.40147920
135Primary immunodeficiency_Homo sapiens_hsa053400.38725731
136Other glycan degradation_Homo sapiens_hsa005110.38564920
137Linoleic acid metabolism_Homo sapiens_hsa005910.38513605
138Acute myeloid leukemia_Homo sapiens_hsa052210.38511869
139Small cell lung cancer_Homo sapiens_hsa052220.35641053
140mTOR signaling pathway_Homo sapiens_hsa041500.35062867
141Glycerolipid metabolism_Homo sapiens_hsa005610.34603339
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.34394706
143Antigen processing and presentation_Homo sapiens_hsa046120.33525671
144Phagosome_Homo sapiens_hsa041450.32556019
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.31548754
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31451796
147Biosynthesis of amino acids_Homo sapiens_hsa012300.31256855
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.30451885
149Dorso-ventral axis formation_Homo sapiens_hsa043200.29580128
150Regulation of autophagy_Homo sapiens_hsa041400.29479678
151Shigellosis_Homo sapiens_hsa051310.28581647
152Non-small cell lung cancer_Homo sapiens_hsa052230.28233836
153ErbB signaling pathway_Homo sapiens_hsa040120.26215145
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24155224
155Ras signaling pathway_Homo sapiens_hsa040140.23835862
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23724139
157Choline metabolism in cancer_Homo sapiens_hsa052310.23672133
158Prostate cancer_Homo sapiens_hsa052150.23218382

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