PLLP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.85946944
2fatty acid elongation (GO:0030497)7.59515457
3nuclear pore organization (GO:0006999)7.11196035
4* ensheathment of neurons (GO:0007272)6.86075360
5* axon ensheathment (GO:0008366)6.86075360
6* myelination (GO:0042552)6.71444834
7innate immune response in mucosa (GO:0002227)6.51288731
8pore complex assembly (GO:0046931)6.01241264
9myelin maintenance (GO:0043217)5.70840738
10long-chain fatty acid biosynthetic process (GO:0042759)5.57384940
11mucosal immune response (GO:0002385)5.28105044
12antibacterial humoral response (GO:0019731)5.13279033
13negative regulation of neurotransmitter secretion (GO:0046929)5.03378629
14oligodendrocyte differentiation (GO:0048709)4.93029159
15organ or tissue specific immune response (GO:0002251)4.88766087
16cholesterol biosynthetic process (GO:0006695)4.71267024
17antimicrobial humoral response (GO:0019730)4.67516404
18embryonic process involved in female pregnancy (GO:0060136)4.64062522
19negative regulation of neurotransmitter transport (GO:0051589)4.55556685
20peptidyl-tyrosine autophosphorylation (GO:0038083)4.53880669
21creatine metabolic process (GO:0006600)4.47854858
22regulation of collateral sprouting (GO:0048670)4.28756808
23response to methylmercury (GO:0051597)4.16710663
24negative regulation of DNA repair (GO:0045738)4.16694843
25glycerophospholipid catabolic process (GO:0046475)4.14877407
26sterol biosynthetic process (GO:0016126)4.11261814
27negative regulation of protein localization to cell surface (GO:2000009)4.10870325
28L-amino acid import (GO:0043092)4.09230122
29presynaptic membrane organization (GO:0097090)4.07257850
30regulation of sister chromatid cohesion (GO:0007063)4.01506150
31asymmetric protein localization (GO:0008105)3.98509905
32establishment of mitochondrion localization (GO:0051654)3.97042404
33substantia nigra development (GO:0021762)3.95565245
34dorsal/ventral axis specification (GO:0009950)3.94989519
35wound healing, spreading of epidermal cells (GO:0035313)3.93011887
36apical protein localization (GO:0045176)3.92533674
37eye photoreceptor cell differentiation (GO:0001754)3.91821047
38photoreceptor cell differentiation (GO:0046530)3.91821047
39protein localization to endosome (GO:0036010)3.91376714
40long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.90492565
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89966016
42cellular protein complex localization (GO:0034629)3.88523219
43astrocyte development (GO:0014002)3.86728702
44presynaptic membrane assembly (GO:0097105)3.83705696
45positive regulation of oligodendrocyte differentiation (GO:0048714)3.81171097
46peripheral nervous system axon ensheathment (GO:0032292)3.79804138
47myelination in peripheral nervous system (GO:0022011)3.79804138
48amyloid precursor protein metabolic process (GO:0042982)3.78074699
49hemidesmosome assembly (GO:0031581)3.73286983
50isoprenoid biosynthetic process (GO:0008299)3.69006042
51import into cell (GO:0098657)3.65173974
52regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.65022971
53peptidyl-lysine dimethylation (GO:0018027)3.63264482
54nucleobase-containing small molecule interconversion (GO:0015949)3.59053051
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.58347938
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.56419645
57response to redox state (GO:0051775)3.53150509
58protein complex localization (GO:0031503)3.48704846
59mature B cell differentiation involved in immune response (GO:0002313)3.46729349
60fatty-acyl-CoA biosynthetic process (GO:0046949)3.41420160
61retina vasculature morphogenesis in camera-type eye (GO:0061299)3.41229624
62phospholipid translocation (GO:0045332)3.34679817
63lipid translocation (GO:0034204)3.34679817
64cell adhesion mediated by integrin (GO:0033627)3.32982109
65response to lipoprotein particle (GO:0055094)3.32676551
66adhesion of symbiont to host cell (GO:0044650)3.32575887
67virion attachment to host cell (GO:0019062)3.32575887
68regulation of hippo signaling (GO:0035330)3.32398431
69negative regulation of axonogenesis (GO:0050771)3.28252452
70adult walking behavior (GO:0007628)3.26452059
71cellular response to ethanol (GO:0071361)3.21819109
72membrane tubulation (GO:0097320)3.20459491
73neuron cell-cell adhesion (GO:0007158)3.18717028
74fatty-acyl-CoA metabolic process (GO:0035337)3.16595092
75protein palmitoylation (GO:0018345)3.15896829
76very long-chain fatty acid metabolic process (GO:0000038)3.14558251
77positive regulation of catenin import into nucleus (GO:0035413)3.14453506
78regulation of transforming growth factor beta2 production (GO:0032909)3.13253700
79amino acid import (GO:0043090)3.10367362
80DNA duplex unwinding (GO:0032508)3.09616631
81neuron remodeling (GO:0016322)3.08335845
82positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06237351
83apoptotic cell clearance (GO:0043277)3.05914280
84mature B cell differentiation (GO:0002335)3.05293496
85polyol biosynthetic process (GO:0046173)3.04873170
86transmission of nerve impulse (GO:0019226)3.04829978
87cellular response to epinephrine stimulus (GO:0071872)3.03292157
88negative regulation of fatty acid transport (GO:2000192)2.98338620
89limb bud formation (GO:0060174)2.98054753
90mitochondrial DNA metabolic process (GO:0032042)2.97168305
91peripheral nervous system development (GO:0007422)2.97047275
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.95906299
93glycosylceramide metabolic process (GO:0006677)2.94727045
94DNA geometric change (GO:0032392)2.94090047
95COPI coating of Golgi vesicle (GO:0048205)2.93863532
96Golgi transport vesicle coating (GO:0048200)2.93863532
97magnesium ion transport (GO:0015693)2.93469990
98eosinophil chemotaxis (GO:0048245)2.92982216
99DNA replication-dependent nucleosome organization (GO:0034723)2.91225765
100DNA replication-dependent nucleosome assembly (GO:0006335)2.91225765
101glycolipid catabolic process (GO:0019377)2.91074245
102labyrinthine layer development (GO:0060711)2.90066884
103urea cycle (GO:0000050)2.89658576
104axon development (GO:0061564)2.88105515
105negative regulation of JUN kinase activity (GO:0043508)2.87336977
106wound healing, spreading of cells (GO:0044319)2.86851062
107negative regulation of axon extension (GO:0030517)2.86813908
108nucleotide transmembrane transport (GO:1901679)2.85376706
109regulation of lipoprotein metabolic process (GO:0050746)2.83537829
110osteoclast differentiation (GO:0030316)2.82580100
111protein localization to cell surface (GO:0034394)2.81937816
112glial cell proliferation (GO:0014009)2.81899997
113ectoderm development (GO:0007398)2.81743446
114regulation of centriole replication (GO:0046599)2.81624062
115heme transport (GO:0015886)2.81354959
116iron coordination entity transport (GO:1901678)2.81123999
117nucleosome assembly (GO:0006334)2.81079835
118amyloid precursor protein catabolic process (GO:0042987)2.79481084
119thioester biosynthetic process (GO:0035384)2.78289843
120acyl-CoA biosynthetic process (GO:0071616)2.78289843
121positive regulation of action potential (GO:0045760)2.77351237
122regulation of centrosome duplication (GO:0010824)2.76949979
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76393556
124cerebral cortex radially oriented cell migration (GO:0021799)2.75555077
125morphogenesis of an epithelial sheet (GO:0002011)2.74954753
126glycine transport (GO:0015816)2.74901374
127neuronal ion channel clustering (GO:0045161)2.73658094
128epithelial cell-cell adhesion (GO:0090136)2.73197418
129negative regulation of execution phase of apoptosis (GO:1900118)2.73094116
130neuronal action potential propagation (GO:0019227)2.73078559
131GPI anchor biosynthetic process (GO:0006506)2.72600988
132glycosphingolipid catabolic process (GO:0046479)2.71197126
133COPII vesicle coating (GO:0048208)2.70956996
134enteric nervous system development (GO:0048484)2.70703878
135chromatin assembly (GO:0031497)2.70528613
136cell-substrate junction assembly (GO:0007044)2.70493469
137oligosaccharide catabolic process (GO:0009313)2.69743486
138positive regulation of glial cell differentiation (GO:0045687)2.69221991
139GPI anchor metabolic process (GO:0006505)2.68955887
140DNA unwinding involved in DNA replication (GO:0006268)2.68772918
141regulation of translational fidelity (GO:0006450)2.67655271
142cellular response to monoamine stimulus (GO:0071868)2.66870481
143cellular response to catecholamine stimulus (GO:0071870)2.66870481
144activation of Rac GTPase activity (GO:0032863)2.65288917
145response to epinephrine (GO:0071871)2.65149473
146neural nucleus development (GO:0048857)2.64802398
147hypotonic response (GO:0006971)2.64423453
148natural killer cell mediated cytotoxicity (GO:0042267)2.64220236
149natural killer cell mediated immunity (GO:0002228)2.64220236
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63434485
151glial cell differentiation (GO:0010001)2.63306447
152positive regulation of gliogenesis (GO:0014015)2.62867813
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62771284
154L-phenylalanine catabolic process (GO:0006559)2.62771284
155glial cell development (GO:0021782)2.62583819
156response to lead ion (GO:0010288)2.61002978
157mitochondrial DNA replication (GO:0006264)2.60888160
158negative regulation of cell fate specification (GO:0009996)2.60854288
159eosinophil migration (GO:0072677)2.60707428
160chondrocyte development (GO:0002063)2.59681782
161peptidyl-cysteine modification (GO:0018198)2.59514096
162midgut development (GO:0007494)2.58999525
163regulation of interleukin-13 production (GO:0032656)2.57547407
164regulation of centrosome cycle (GO:0046605)2.57135473
165positive regulation of cellular amine metabolic process (GO:0033240)2.57059837
166cyclic nucleotide catabolic process (GO:0009214)2.56391402
167deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.55178595
168glycoprotein catabolic process (GO:0006516)2.54628039
169nerve growth factor signaling pathway (GO:0038180)2.54163837
170urea metabolic process (GO:0019627)2.53647026
171leukocyte migration involved in inflammatory response (GO:0002523)2.51632283
172positive regulation of endothelial cell apoptotic process (GO:2000353)2.50787150
173neurotransmitter uptake (GO:0001504)2.49757252
174Leydig cell differentiation (GO:0033327)2.49485265
175Golgi organization (GO:0007030)2.48826954
176negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.48077376
177interleukin-6-mediated signaling pathway (GO:0070102)2.47901455
178cerebellar granule cell differentiation (GO:0021707)2.47134814
179protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.46164757
180centrosome duplication (GO:0051298)2.45608035
181response to hydroperoxide (GO:0033194)2.45232630
182detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44851923
183detection of temperature stimulus involved in sensory perception (GO:0050961)2.44851923
184mammary gland epithelial cell proliferation (GO:0033598)2.44632593
185pinocytosis (GO:0006907)2.44568531
186paraxial mesoderm development (GO:0048339)2.43805138
187regulation of protein polyubiquitination (GO:1902914)2.43204626
188positive regulation of keratinocyte differentiation (GO:0045618)2.40465368
189necroptotic process (GO:0070266)2.39196988
190dosage compensation (GO:0007549)2.36898265
191histone-serine phosphorylation (GO:0035404)2.35679125
192adherens junction assembly (GO:0034333)2.35091876
193heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.35048284
194embryonic camera-type eye morphogenesis (GO:0048596)2.34043069
195epithelial cell differentiation involved in prostate gland development (GO:0060742)2.33857804
196positive regulation of DNA-templated transcription, initiation (GO:2000144)2.33052356
197embryonic foregut morphogenesis (GO:0048617)2.31820473
198axon ensheathment in central nervous system (GO:0032291)11.3993259
199central nervous system myelination (GO:0022010)11.3993259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.48174987
2E2F7_22180533_ChIP-Seq_HELA_Human4.33852739
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.25073041
4GBX2_23144817_ChIP-Seq_PC3_Human3.04192468
5GATA1_22025678_ChIP-Seq_K562_Human2.98709788
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.92031024
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.70300683
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.64203399
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47417094
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44541719
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39150303
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33626285
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26660795
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24565450
15AR_21572438_ChIP-Seq_LNCaP_Human2.08735620
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08336908
17EZH2_22144423_ChIP-Seq_EOC_Human2.04768692
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04556655
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04556655
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.03034874
21TAF15_26573619_Chip-Seq_HEK293_Human2.02854370
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02118876
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02118876
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01857446
25AR_21909140_ChIP-Seq_LNCAP_Human2.01223472
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.4444011
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98730245
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95280771
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94727402
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.91793430
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.90760093
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90616810
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90051990
34* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86327848
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85908010
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79661059
37DROSHA_22980978_ChIP-Seq_HELA_Human1.77092741
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69375895
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66507466
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65619391
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63758430
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.61537676
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58378998
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58072075
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57449579
46ER_23166858_ChIP-Seq_MCF-7_Human1.56861704
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.54403628
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54245611
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.49459058
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48542033
51VDR_22108803_ChIP-Seq_LS180_Human1.47669292
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45181029
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.44649167
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44011372
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.42945798
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42671953
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.42512197
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41459303
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.41108877
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.39694725
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38268474
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.35794074
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33895829
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33249059
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32296645
66TP53_16413492_ChIP-PET_HCT116_Human1.32153936
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.32119317
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31537658
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30318236
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29786437
71* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29778385
72CLOCK_20551151_ChIP-Seq_293T_Human1.23238742
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23190988
74* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23167291
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.23166526
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21309057
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20451916
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20451916
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19706314
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17133371
81REST_21632747_ChIP-Seq_MESCs_Mouse1.17076588
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.16559547
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16533693
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15878467
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13918766
86* BRD4_25478319_ChIP-Seq_HGPS_Human1.12980017
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12590580
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11456593
89ZNF263_19887448_ChIP-Seq_K562_Human1.10970396
90* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10321453
91P300_19829295_ChIP-Seq_ESCs_Human1.09413630
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08870339
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08774081
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07989191
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07941331
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07241419
97STAT3_23295773_ChIP-Seq_U87_Human1.06837905
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.06374524
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05636113
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05174009
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05060947
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04843811
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04738702
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04655768
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04182458
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.03973179
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03388911
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03028258
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02568865
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.02379748
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01860539
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01657100
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01648505
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01592410
115* TAL1_26923725_Chip-Seq_HPCs_Mouse1.01563132
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01533184
117TP53_18474530_ChIP-ChIP_U2OS_Human1.00308295
118HTT_18923047_ChIP-ChIP_STHdh_Human1.00071933
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.00065332
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.99154224
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98917280
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.98319488
123* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96930929
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96863864
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96836424
126AHR_22903824_ChIP-Seq_MCF-7_Human0.96574155
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96304990
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96284898
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.96075967
130TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95386786
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94559951
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94318632
133SMAD4_21799915_ChIP-Seq_A2780_Human0.93673238
134* EOMES_21245162_ChIP-Seq_HESCs_Human0.92875981
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92707294
136FUS_26573619_Chip-Seq_HEK293_Human0.92434919
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.92214603
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.92202844
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.91883156
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91340134
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89786286
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89063027
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.88879749
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88465747
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88083035
146ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87985212
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87622553
148RNF2_27304074_Chip-Seq_NSC_Mouse0.87572762
149TFEB_21752829_ChIP-Seq_HELA_Human0.87379742
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87288985
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.87262401
152ELK1_19687146_ChIP-ChIP_HELA_Human0.87250152
153* TCF4_23295773_ChIP-Seq_U87_Human0.86905274
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.86502723
155P300_18555785_Chip-Seq_ESCs_Mouse0.86160010
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86071017
157SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85831027
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84774323
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84705368
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84115883
161* GATA6_25053715_ChIP-Seq_YYC3_Human0.83131732
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83023382
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.82998724
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82945005
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82895121
166* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82743667
167* CJUN_26792858_Chip-Seq_BT549_Human0.82045001
168TP63_23658742_ChIP-Seq_EP156T_Human0.81302540
169TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80836113
170STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79706045
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79076932
172NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78836683
173NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78002474
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77776418
175KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77470647
176CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77318133
177SALL4_22934838_ChIP-ChIP_CD34+_Human0.75704159
178SOX17_20123909_ChIP-Seq_XEN_Mouse0.75282605
179MYC_18555785_ChIP-Seq_MESCs_Mouse0.74771903
180P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74172630
181SOX2_16153702_ChIP-ChIP_HESCs_Human0.73842243
182ATF3_27146783_Chip-Seq_COLON_Human0.72781557
183ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.71482999
184JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71381421
185PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69720973
186RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68857491
187CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67534701
188SOX2_18692474_ChIP-Seq_MESCs_Mouse0.67424295
189IRF1_19129219_ChIP-ChIP_H3396_Human0.67240497
190CHD1_26751641_Chip-Seq_LNCaP_Human0.66479387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.75085610
2MP0010234_abnormal_vibrissa_follicle5.53627103
3MP0010352_gastrointestinal_tract_polyps4.35106859
4MP0003880_abnormal_central_pattern4.07266149
5MP0003705_abnormal_hypodermis_morpholog4.06326816
6MP0008057_abnormal_DNA_replication3.61861302
7MP0004270_analgesia3.28953728
8MP0003690_abnormal_glial_cell3.22313551
9MP0002877_abnormal_melanocyte_morpholog3.09849827
10MP0003950_abnormal_plasma_membrane3.06040368
11MP0002009_preneoplasia2.97565375
12MP0004885_abnormal_endolymph2.94689262
13MP0005171_absent_coat_pigmentation2.93330912
14MP0000537_abnormal_urethra_morphology2.90243555
15MP0001529_abnormal_vocalization2.74913827
16MP0004742_abnormal_vestibular_system2.65355312
17MP0003329_amyloid_beta_deposits2.63241458
18MP0002272_abnormal_nervous_system2.58487958
19MP0003634_abnormal_glial_cell2.52465460
20MP0003941_abnormal_skin_development2.51639940
21MP0003136_yellow_coat_color2.51286340
22MP0001486_abnormal_startle_reflex2.49938885
23MP0000569_abnormal_digit_pigmentation2.43942892
24MP0004142_abnormal_muscle_tone2.36503627
25MP0002064_seizures2.25224390
26MP0003191_abnormal_cellular_cholesterol2.25108572
27MP0001905_abnormal_dopamine_level2.21997008
28MP0004859_abnormal_synaptic_plasticity2.12073880
29MP0001485_abnormal_pinna_reflex2.11321822
30MP0000778_abnormal_nervous_system2.09392738
31MP0004185_abnormal_adipocyte_glucose2.08680685
32MP0003453_abnormal_keratinocyte_physiol1.98942441
33MP0005423_abnormal_somatic_nervous1.96276596
34MP0005409_darkened_coat_color1.96089494
35MP0000465_gastrointestinal_hemorrhage1.95874635
36MP0002229_neurodegeneration1.93352813
37MP0003566_abnormal_cell_adhesion1.91608372
38MP0003632_abnormal_nervous_system1.86726931
39MP0000462_abnormal_digestive_system1.85509179
40MP0004381_abnormal_hair_follicle1.85488467
41MP0002734_abnormal_mechanical_nocicepti1.84779393
42MP0006054_spinal_hemorrhage1.78183409
43MP0009745_abnormal_behavioral_response1.76451295
44MP0010307_abnormal_tumor_latency1.75701003
45MP0003635_abnormal_synaptic_transmissio1.71520700
46MP0010678_abnormal_skin_adnexa1.67718414
47MP0009046_muscle_twitch1.67387843
48MP0004272_abnormal_basement_membrane1.66893876
49MP0005410_abnormal_fertilization1.66829601
50MP0008260_abnormal_autophagy1.66649032
51MP0004043_abnormal_pH_regulation1.64925269
52MP0003091_abnormal_cell_migration1.63007242
53MP0000383_abnormal_hair_follicle1.56050056
54MP0005451_abnormal_body_composition1.55820197
55MP0002092_abnormal_eye_morphology1.53697755
56MP0001915_intracranial_hemorrhage1.52394037
57MP0004957_abnormal_blastocyst_morpholog1.51193399
58MP0003077_abnormal_cell_cycle1.49452616
59MP0003806_abnormal_nucleotide_metabolis1.47066534
60MP0003631_nervous_system_phenotype1.46852058
61MP0009379_abnormal_foot_pigmentation1.45841616
62MP0000955_abnormal_spinal_cord1.45291052
63MP0000733_abnormal_muscle_development1.42318070
64MP0001849_ear_inflammation1.41606751
65MP0008007_abnormal_cellular_replicative1.39168258
66MP0008569_lethality_at_weaning1.37846969
67MP0002882_abnormal_neuron_morphology1.37666290
68MP0003300_gastrointestinal_ulcer1.37148757
69MP0002098_abnormal_vibrissa_morphology1.37039625
70MP0000604_amyloidosis1.36619418
71MP0005551_abnormal_eye_electrophysiolog1.35374338
72MP0005248_abnormal_Harderian_gland1.35224596
73MP0000013_abnormal_adipose_tissue1.34209559
74MP0000747_muscle_weakness1.33368922
75MP0001440_abnormal_grooming_behavior1.31220275
76MP0002572_abnormal_emotion/affect_behav1.31203441
77MP0004233_abnormal_muscle_weight1.30064499
78MP0005275_abnormal_skin_tensile1.29935599
79MP0001970_abnormal_pain_threshold1.29654565
80MP0002060_abnormal_skin_morphology1.27905988
81MP0002066_abnormal_motor_capabilities/c1.27337565
82MP0005076_abnormal_cell_differentiation1.27140730
83MP0003633_abnormal_nervous_system1.26821567
84MP0002697_abnormal_eye_size1.26713422
85MP0003868_abnormal_feces_composition1.25672213
86MP0004134_abnormal_chest_morphology1.24820821
87MP0000428_abnormal_craniofacial_morphol1.22091518
88MP0002063_abnormal_learning/memory/cond1.21976444
89MP0001963_abnormal_hearing_physiology1.21867417
90MP0000377_abnormal_hair_follicle1.21144695
91MP0002166_altered_tumor_susceptibility1.20907767
92MP0002067_abnormal_sensory_capabilities1.20073353
93MP0002896_abnormal_bone_mineralization1.17728158
94MP0000427_abnormal_hair_cycle1.14573246
95MP0001346_abnormal_lacrimal_gland1.13926290
96MP0002752_abnormal_somatic_nervous1.13893632
97MP0002733_abnormal_thermal_nociception1.12529002
98MP0004147_increased_porphyrin_level1.12519818
99MP0002822_catalepsy1.11933821
100MP0003221_abnormal_cardiomyocyte_apopto1.11221251
101MP0004808_abnormal_hematopoietic_stem1.09735675
102MP0005408_hypopigmentation1.09610935
103MP0002006_tumorigenesis1.08665689
104MP0002086_abnormal_extraembryonic_tissu1.08465790
105MP0005386_behavior/neurological_phenoty1.07894350
106MP0004924_abnormal_behavior1.07894350
107MP0005623_abnormal_meninges_morphology1.07808239
108MP0009053_abnormal_anal_canal1.07471215
109MP0003195_calcinosis1.05945462
110MP0000371_diluted_coat_color1.04694080
111MP0001299_abnormal_eye_distance/1.02198023
112MP0005257_abnormal_intraocular_pressure1.02154871
113MP0003111_abnormal_nucleus_morphology1.02004710
114MP0001661_extended_life_span1.02002742
115MP0010094_abnormal_chromosome_stability1.01333924
116MP0004264_abnormal_extraembryonic_tissu0.99473285
117MP0001216_abnormal_epidermal_layer0.99328259
118MP0005501_abnormal_skin_physiology0.98571622
119MP0005058_abnormal_lysosome_morphology0.96521182
120MP0001968_abnormal_touch/_nociception0.96110094
121MP0005023_abnormal_wound_healing0.95750737
122MP0000467_abnormal_esophagus_morphology0.92948359
123MP0003828_pulmonary_edema0.91184203
124MP0001879_abnormal_lymphatic_vessel0.90698194
125MP0005197_abnormal_uvea_morphology0.90588192
126MP0002084_abnormal_developmental_patter0.89931820
127MP0001177_atelectasis0.89125304
128MP0000015_abnormal_ear_pigmentation0.88944765
129MP0005380_embryogenesis_phenotype0.88324903
130MP0001672_abnormal_embryogenesis/_devel0.88324903
131MP0005195_abnormal_posterior_eye0.88133352
132MP0004130_abnormal_muscle_cell0.87449377
133MP0003984_embryonic_growth_retardation0.87248272
134MP0000627_abnormal_mammary_gland0.87239770
135MP0009840_abnormal_foam_cell0.87191393
136MP0003385_abnormal_body_wall0.87119902
137MP0000350_abnormal_cell_proliferation0.87030353
138MP0004145_abnormal_muscle_electrophysio0.84072332
139MP0002088_abnormal_embryonic_growth/wei0.83997864
140MP0000762_abnormal_tongue_morphology0.83451606
141MP0000647_abnormal_sebaceous_gland0.83269557
142MP0003890_abnormal_embryonic-extraembry0.82798355
143MP0003252_abnormal_bile_duct0.81617651
144MP0004947_skin_inflammation0.81359539
145MP0000566_synostosis0.80249985
146MP0000358_abnormal_cell_content/0.79560859
147MP0002295_abnormal_pulmonary_circulatio0.78750477
148MP0001666_abnormal_nutrient_absorption0.78218610
149MP0008438_abnormal_cutaneous_collagen0.77956699
150MP0002152_abnormal_brain_morphology0.77866522
151MP0000490_abnormal_crypts_of0.77157166
152MP0002736_abnormal_nociception_after0.76387485
153MP0002254_reproductive_system_inflammat0.76287267
154MP0002796_impaired_skin_barrier0.76275306
155MP0009384_cardiac_valve_regurgitation0.75885179
156MP0000579_abnormal_nail_morphology0.75432706
157MP0000026_abnormal_inner_ear0.75235179
158MP0002111_abnormal_tail_morphology0.74514495
159MP0003786_premature_aging0.73765767
160MP0001986_abnormal_taste_sensitivity0.73364134
161MP0005193_abnormal_anterior_eye0.72913582
162MP0003938_abnormal_ear_development0.72762326
163MP0001851_eye_inflammation0.71482550
164MP0002735_abnormal_chemical_nociception0.69976383
165MP0005391_vision/eye_phenotype0.69589236
166MP0010771_integument_phenotype0.68867276
167MP0001502_abnormal_circadian_rhythm0.67649330
168MP0002557_abnormal_social/conspecific_i0.66909770
169MP0001501_abnormal_sleep_pattern0.66320775
170MP0003937_abnormal_limbs/digits/tail_de0.65991401
171MP0002184_abnormal_innervation0.64665450
172MP0002090_abnormal_vision0.64148503
173MP0005253_abnormal_eye_physiology0.62374482
174MP0001664_abnormal_digestion0.58341421
175MP0004811_abnormal_neuron_physiology0.58037889
176MP0000749_muscle_degeneration0.57986999
177MP0000639_abnormal_adrenal_gland0.57105598
178MP0000003_abnormal_adipose_tissue0.55291651
179MP0005645_abnormal_hypothalamus_physiol0.54429282
180MP0002118_abnormal_lipid_homeostasis0.53747461
181MP0002133_abnormal_respiratory_system0.53589962
182MP0005388_respiratory_system_phenotype0.53589962

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.24158250
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.24158250
3Neurofibrillary tangles (HP:0002185)5.97407821
4Peripheral hypomyelination (HP:0007182)5.38195750
5Cerebral hypomyelination (HP:0006808)4.85569811
6Sensory axonal neuropathy (HP:0003390)4.73170265
7Abnormality of the corticospinal tract (HP:0002492)4.70244090
8Parakeratosis (HP:0001036)4.68151433
9Onion bulb formation (HP:0003383)4.46781703
10Cerebral inclusion bodies (HP:0100314)4.25457278
11Abnormal auditory evoked potentials (HP:0006958)3.88759345
12Termporal pattern (HP:0011008)3.80004829
13Insidious onset (HP:0003587)3.80004829
14Osteolytic defects of the phalanges of the hand (HP:0009771)3.75553967
15Osteolytic defects of the hand bones (HP:0009699)3.75553967
16Alacrima (HP:0000522)3.64620304
17Segmental peripheral demyelination/remyelination (HP:0003481)3.64124468
18Subacute progressive viral hepatitis (HP:0006572)3.62912460
19Supranuclear gaze palsy (HP:0000605)3.58079017
20Spastic gait (HP:0002064)3.46362603
21Intention tremor (HP:0002080)3.40007827
22Ankyloglossia (HP:0010296)3.31389299
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30554992
24Dysmetria (HP:0001310)3.27160147
25Ankle clonus (HP:0011448)3.24912573
26Spastic diplegia (HP:0001264)3.23811867
27Spinal cord lesions (HP:0100561)3.23482842
28Syringomyelia (HP:0003396)3.23482842
29Leukodystrophy (HP:0002415)3.20949710
30Abnormality of oral frenula (HP:0000190)3.20766821
31Dysmetric saccades (HP:0000641)3.18816670
32Colitis (HP:0002583)3.18804201
33Absent frontal sinuses (HP:0002688)3.17264482
34Short nail (HP:0001799)3.11891977
35Interstitial pulmonary disease (HP:0006530)3.08750394
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07359151
37Tetraparesis (HP:0002273)3.06571166
38Spastic paraparesis (HP:0002313)3.05789585
39Myokymia (HP:0002411)3.04067381
40Papillary thyroid carcinoma (HP:0002895)2.99982947
41Asymmetry of the thorax (HP:0001555)2.95970173
42CNS hypomyelination (HP:0003429)2.90916979
43Decreased lacrimation (HP:0000633)2.88005412
44Akinesia (HP:0002304)2.81618217
45Slow saccadic eye movements (HP:0000514)2.80684763
46Increased serum pyruvate (HP:0003542)2.79171496
47Abnormality of glycolysis (HP:0004366)2.79171496
48Morphological abnormality of the inner ear (HP:0011390)2.74757020
49Scanning speech (HP:0002168)2.68348553
50Entropion (HP:0000621)2.67228402
51Premature skin wrinkling (HP:0100678)2.66709092
52Action tremor (HP:0002345)2.59988518
53Myocardial infarction (HP:0001658)2.56826194
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56365717
55Retinal dysplasia (HP:0007973)2.56083158
56Increased circulating renin level (HP:0000848)2.55412405
57Hypoplastic pelvis (HP:0008839)2.53238631
58IgM deficiency (HP:0002850)2.50773776
59Relative macrocephaly (HP:0004482)2.48414870
60Ulnar bowing (HP:0003031)2.47196236
61Gastrointestinal carcinoma (HP:0002672)2.46864107
62Malignant gastrointestinal tract tumors (HP:0006749)2.46864107
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.46166120
64Foot dorsiflexor weakness (HP:0009027)2.45765668
65Uterine leiomyosarcoma (HP:0002891)2.45643119
66Leiomyosarcoma (HP:0100243)2.45643119
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.45584097
68Thickened helices (HP:0000391)2.45530670
69Congenital ichthyosiform erythroderma (HP:0007431)2.44482625
70Metabolic alkalosis (HP:0200114)2.44432071
71IgA deficiency (HP:0002720)2.43465469
72Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.43337524
73Progressive external ophthalmoplegia (HP:0000590)2.42940363
74Hypoplasia of the iris (HP:0007676)2.42589169
75Cutaneous melanoma (HP:0012056)2.40731454
76Hyperacusis (HP:0010780)2.40131202
77White forelock (HP:0002211)2.39849628
78Renovascular hypertension (HP:0100817)2.36284684
79Clumsiness (HP:0002312)2.34845258
80Poor speech (HP:0002465)2.33873896
81Absent septum pellucidum (HP:0001331)2.33661633
82Spastic tetraparesis (HP:0001285)2.33392176
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.32455168
84Axonal loss (HP:0003447)2.32230548
85Paraparesis (HP:0002385)2.32113948
86Patchy hypopigmentation of hair (HP:0011365)2.32097463
87Hypomagnesemia (HP:0002917)2.31584708
88Stridor (HP:0010307)2.31386677
89Split foot (HP:0001839)2.31023291
90Peripheral demyelination (HP:0011096)2.30335820
91Mitral stenosis (HP:0001718)2.29544544
92Short chin (HP:0000331)2.28242187
93Anteriorly placed anus (HP:0001545)2.26163726
94Cerebral hemorrhage (HP:0001342)2.25553753
95Abnormality of the astrocytes (HP:0100707)2.24148521
96Astrocytoma (HP:0009592)2.24148521
97Flat acetabular roof (HP:0003180)2.23331784
98Abnormality of the foot musculature (HP:0001436)2.21759565
99Missing ribs (HP:0000921)2.20120137
100Subcapsular cataract (HP:0000523)2.19355424
101Autoamputation (HP:0001218)2.18696751
102Decreased motor nerve conduction velocity (HP:0003431)2.18206678
103Aplasia cutis congenita (HP:0001057)2.17157739
104Germ cell neoplasia (HP:0100728)2.17073892
105Thyroid carcinoma (HP:0002890)2.16865435
106Hammertoe (HP:0001765)2.15971445
107Pheochromocytoma (HP:0002666)2.15177982
108Muscle fiber splitting (HP:0003555)2.13954324
109Hypokalemic alkalosis (HP:0001949)2.12513957
110Selective tooth agenesis (HP:0001592)2.11776853
111Micronodular cirrhosis (HP:0001413)2.11384787
112Abnormal foot bone ossification (HP:0010675)2.10850919
113Abnormality of the distal phalanx of the thumb (HP:0009617)2.10841758
114Coronal craniosynostosis (HP:0004440)2.10829982
115Chromsome breakage (HP:0040012)2.10321706
116Spinal cord compression (HP:0002176)2.09898110
117Lower limb muscle weakness (HP:0007340)2.08420562
118Curly hair (HP:0002212)2.07561245
119Neoplasm of the peripheral nervous system (HP:0100007)2.06850139
120Ulnar claw (HP:0001178)2.05492249
121Transitional cell carcinoma of the bladder (HP:0006740)2.03883478
122Broad ribs (HP:0000885)2.03488687
123Clonus (HP:0002169)2.01945612
124Bladder neoplasm (HP:0009725)2.01771317
125Bladder carcinoma (HP:0002862)2.01771317
126Esophageal atresia (HP:0002032)2.01442712
127Insomnia (HP:0100785)2.01218609
128Sandal gap (HP:0001852)2.00953425
129Abnormality of nail color (HP:0100643)2.00369919
130Aplasia involving bones of the upper limbs (HP:0009823)2.00003519
131Aplasia of the phalanges of the hand (HP:0009802)2.00003519
132Aplasia involving bones of the extremities (HP:0009825)2.00003519
133Limb dystonia (HP:0002451)1.99433599
13411 pairs of ribs (HP:0000878)1.99076373
135Distal sensory impairment (HP:0002936)1.99037113
136Vertebral arch anomaly (HP:0008438)1.98042975
137Ependymoma (HP:0002888)1.98041537
138Thin bony cortex (HP:0002753)1.95690274
139Hepatosplenomegaly (HP:0001433)1.94886541
140Abnormality of the septum pellucidum (HP:0007375)1.92754836
141Periodontitis (HP:0000704)1.91752950
142Deep philtrum (HP:0002002)1.91471968
143Distal lower limb amyotrophy (HP:0008944)1.91093168
144Partial agenesis of the corpus callosum (HP:0001338)1.91027399
145Natal tooth (HP:0000695)1.90887866
146Megalencephaly (HP:0001355)1.90629494
147Partial duplication of thumb phalanx (HP:0009944)1.90467143
148Short humerus (HP:0005792)1.90202259
149Choreoathetosis (HP:0001266)1.89750263
150Urinary incontinence (HP:0000020)1.86290380
151Heterotopia (HP:0002282)1.86253743
152Humeroradial synostosis (HP:0003041)1.86056481
153Synostosis involving the elbow (HP:0003938)1.86056481
154Abnormal glucose tolerance (HP:0001952)1.85994231
155Hypophosphatemic rickets (HP:0004912)1.85976719
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85807203
157Bowel incontinence (HP:0002607)1.85320982
158Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83018297
159Neonatal hypoglycemia (HP:0001998)1.82743443
160Glioma (HP:0009733)1.82711007
161Elfin facies (HP:0004428)1.82702156
162Short clavicles (HP:0000894)1.82440473
163Neuroendocrine neoplasm (HP:0100634)1.82269277
164Abnormality of magnesium homeostasis (HP:0004921)1.81625324
165Viral hepatitis (HP:0006562)1.81031607
166Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80601759
167Hypoalphalipoproteinemia (HP:0003233)1.80271924
168Steppage gait (HP:0003376)1.79125859
169Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79041712
170Cupped ear (HP:0000378)1.78138112
171Urinary urgency (HP:0000012)1.77782858
172Morphological abnormality of the pyramidal tract (HP:0002062)1.77147941
173Abnormality of the distal phalanges of the toes (HP:0010182)1.76913189
174Hypolipoproteinemia (HP:0010981)1.76405185
175Hyporeflexia of lower limbs (HP:0002600)1.76215251
176Wormian bones (HP:0002645)1.76196217
177Abnormality of the middle phalanges of the toes (HP:0010183)1.75762112
178Skull defect (HP:0001362)1.75659586
179Lower limb hyperreflexia (HP:0002395)1.75616024
180Infantile muscular hypotonia (HP:0008947)1.75002649
181Overgrowth (HP:0001548)1.72876129
182Flat cornea (HP:0007720)1.71104943
183Abnormal large intestine physiology (HP:0012700)1.70991041
184Gowers sign (HP:0003391)1.70604123
185Posterior subcapsular cataract (HP:0007787)1.70403742
186Multiple lipomas (HP:0001012)1.70318379
187Premature rupture of membranes (HP:0001788)1.69829768
188Abnormality of the salivary glands (HP:0010286)1.69777985
189Abnormality of the frontal sinuses (HP:0002687)1.69671359
190Abnormal ossification of hand bones (HP:0005921)1.69442113
191Bilateral sensorineural hearing impairment (HP:0008619)1.69233825
192Cellulitis (HP:0100658)1.68491285
193Upper motor neuron abnormality (HP:0002127)1.68485638
194Hypopigmentation of the fundus (HP:0007894)1.66496995
195Breast carcinoma (HP:0003002)1.66431449
196Large earlobe (HP:0009748)1.66325000
197Scapular winging (HP:0003691)1.64695548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.25071296
2ZAK4.90169235
3OXSR14.50406292
4SCYL24.23338043
5TLK14.20931642
6EPHB13.35116823
7EEF2K3.05870047
8PKN12.91600787
9TTN2.66989999
10WNK42.58262055
11BCR2.52152039
12IRAK32.45229148
13TRIB32.34053566
14CDK192.29998991
15MST1R2.29196385
16LIMK12.26168306
17MET2.24503259
18PRPF4B2.15263499
19MAPKAPK52.14275930
20FGFR22.11486340
21PBK2.10174009
22STK241.99340165
23MAP3K121.93443677
24EPHA21.93104605
25UHMK11.92577173
26TNIK1.91795073
27TESK21.88443562
28NEK61.88088930
29WNK11.86068616
30CSNK1G31.83651917
31EIF2AK31.82020833
32CASK1.79236495
33CSNK1A1L1.77968718
34ICK1.76265956
35NME21.69415381
36NTRK11.61700527
37CAMK2B1.60255099
38ROCK21.52192748
39STK38L1.48788394
40CLK11.47805799
41CSNK1G11.41631102
42BMPR21.41418848
43CSNK1G21.40945585
44PDGFRA1.38250340
45ERBB31.37439638
46TYRO31.37308112
47PKN21.37201878
48PAK61.35658678
49CDK61.35424530
50SGK2231.34179970
51SGK4941.34179970
52EPHA41.33929275
53CAMK2D1.33180380
54PNCK1.32873130
55MAP3K101.25262718
56NEK91.22461264
57MST41.19532713
58LATS21.15625001
59FGR1.14860190
60CAMK2G1.09905084
61ILK1.09370160
62ACVR1B1.08950938
63PAK41.07321996
64AKT30.98964940
65MARK10.98930482
66LATS10.98003501
67STK30.92919417
68MAP3K40.91144520
69NEK10.90670950
70DYRK20.89851022
71PIM10.89602127
72MARK20.87475428
73PHKG20.85876686
74PHKG10.85876686
75IRAK20.84667746
76PRKCQ0.84364149
77RPS6KB20.83946269
78CDK140.83787405
79MAPK150.83729724
80CAMKK20.83691651
81RAF10.83197013
82PAK30.83187843
83CDK50.82786341
84ABL20.81413320
85PRKD10.80599680
86MELK0.79678404
87PAK20.79388102
88CAMK2A0.79297320
89KSR10.78570085
90PDPK10.76653031
91RET0.76269971
92STK40.75216048
93ERBB40.75193092
94CHEK20.75058139
95VRK10.74902775
96CDK150.73577009
97RPS6KB10.72214468
98BRSK20.72154756
99TSSK60.71849809
100MUSK0.71755914
101KSR20.71412987
102ARAF0.71281242
103SRPK10.68979818
104CDK180.67949640
105MAP2K70.66776825
106MAP3K60.66755213
107AURKB0.66604736
108CDK11A0.65871844
109RPS6KA40.65097051
110FER0.64735146
111PRKCE0.63771334
112TRPM70.62852973
113TTK0.62708623
114FGFR30.62606975
115MAP2K40.61016660
116FYN0.60930996
117LMTK20.57954113
118MAP3K130.57714330
119BRAF0.56859186
120PDK20.52914864
121IRAK10.51537200
122MAP2K20.51396591
123NTRK20.50981077
124PIM20.50214791
125GSK3A0.50163723
126AURKA0.48709985
127MAPK130.47884672
128SGK30.47653029
129JAK10.47484287
130BRD40.47319214
131PRKG10.45775676
132PIK3CG0.44405397
133MAP3K20.44014388
134FES0.43291656
135CSNK1D0.42934024
136CSNK1A10.42725891
137CCNB10.42322312
138PRKCH0.42147595
139MTOR0.41273903
140PDK10.41019046
141BUB10.40854975
142PRKD30.39746558
143CAMK1D0.39656364
144PAK10.39576429
145STK110.39287700
146GRK10.38952824
147PIK3CA0.37780807
148BMPR1B0.37208351
149PDGFRB0.36992136
150PRKACB0.36910256
151DAPK30.36032760
152CDC70.35628001
153EPHB20.35336311
154DDR20.34857065
155MAPK70.34136866
156RPS6KA50.32849037
157MAP3K80.32797981
158PTK60.32037216
159ROCK10.30359106
160MAP2K30.29481022
161PRKAA10.29332267
162PRKACA0.28801540
163MAPK110.28331311
164GRK70.28004051
165CAMK1G0.27481264
166BMX0.27275675
167SGK20.26965025
168BLK0.26783655
169DMPK0.26760507
170BTK0.26654039
171RPS6KC10.26651713
172RPS6KL10.26651713
173ITK0.26370453
174INSR0.25991389
175MAPK100.24262115
176NTRK30.23358595
177PTK2B0.22939723
178SRC0.22629886
179PRKCZ0.22480909

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053227.63505204
2Alcoholism_Homo sapiens_hsa050345.53055696
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.38833876
4Steroid biosynthesis_Homo sapiens_hsa001004.38431086
5Fatty acid elongation_Homo sapiens_hsa000624.24592446
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.61915421
7Ether lipid metabolism_Homo sapiens_hsa005652.75425180
8Viral carcinogenesis_Homo sapiens_hsa052032.71385876
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70017207
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57458754
11Sulfur metabolism_Homo sapiens_hsa009202.27482748
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13014083
13Nitrogen metabolism_Homo sapiens_hsa009102.12237262
14Vitamin B6 metabolism_Homo sapiens_hsa007501.88398000
15Axon guidance_Homo sapiens_hsa043601.82365185
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74396107
17Sphingolipid metabolism_Homo sapiens_hsa006001.73177911
18Butanoate metabolism_Homo sapiens_hsa006501.72478073
19Histidine metabolism_Homo sapiens_hsa003401.64022257
20Oxidative phosphorylation_Homo sapiens_hsa001901.56420126
21Small cell lung cancer_Homo sapiens_hsa052221.55313766
22Chronic myeloid leukemia_Homo sapiens_hsa052201.49705957
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49283980
24Non-small cell lung cancer_Homo sapiens_hsa052231.49210858
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46385109
26Protein export_Homo sapiens_hsa030601.44933904
27p53 signaling pathway_Homo sapiens_hsa041151.44612424
28Linoleic acid metabolism_Homo sapiens_hsa005911.43352395
29Inositol phosphate metabolism_Homo sapiens_hsa005621.43143826
30Thyroid cancer_Homo sapiens_hsa052161.43066282
31Endometrial cancer_Homo sapiens_hsa052131.42194442
32Proteoglycans in cancer_Homo sapiens_hsa052051.41337505
33Glioma_Homo sapiens_hsa052141.36081622
34Pancreatic cancer_Homo sapiens_hsa052121.35216449
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35024680
36Bladder cancer_Homo sapiens_hsa052191.29774212
37MicroRNAs in cancer_Homo sapiens_hsa052061.24594104
38GABAergic synapse_Homo sapiens_hsa047271.23987117
39Other glycan degradation_Homo sapiens_hsa005111.23646096
40TGF-beta signaling pathway_Homo sapiens_hsa043501.22441129
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22125652
42Glutamatergic synapse_Homo sapiens_hsa047241.21070403
43Colorectal cancer_Homo sapiens_hsa052101.17983981
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17663018
45Arginine and proline metabolism_Homo sapiens_hsa003301.17189684
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16855236
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16025349
48Focal adhesion_Homo sapiens_hsa045101.14849581
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12745774
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.12705287
51Serotonergic synapse_Homo sapiens_hsa047261.10284111
52Adherens junction_Homo sapiens_hsa045201.07241980
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04245129
54Alzheimers disease_Homo sapiens_hsa050101.03759890
55Non-homologous end-joining_Homo sapiens_hsa034501.03017195
56Parkinsons disease_Homo sapiens_hsa050121.01133424
57Hippo signaling pathway_Homo sapiens_hsa043901.00341964
58Collecting duct acid secretion_Homo sapiens_hsa049661.00047982
59Tight junction_Homo sapiens_hsa045300.99060295
60Fatty acid metabolism_Homo sapiens_hsa012120.98970752
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96803362
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96227786
63Morphine addiction_Homo sapiens_hsa050320.95305213
64mTOR signaling pathway_Homo sapiens_hsa041500.94161839
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93555962
66Cell cycle_Homo sapiens_hsa041100.93343227
67Vibrio cholerae infection_Homo sapiens_hsa051100.92949727
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92418070
69HIF-1 signaling pathway_Homo sapiens_hsa040660.92025754
70Long-term depression_Homo sapiens_hsa047300.90247863
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90244982
72Renal cell carcinoma_Homo sapiens_hsa052110.90010026
73Prolactin signaling pathway_Homo sapiens_hsa049170.87246042
74Propanoate metabolism_Homo sapiens_hsa006400.84342007
75VEGF signaling pathway_Homo sapiens_hsa043700.83040807
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82623320
77Glutathione metabolism_Homo sapiens_hsa004800.82240101
78Apoptosis_Homo sapiens_hsa042100.81654734
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81558242
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81218221
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80253405
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.79543359
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.77519179
84Protein digestion and absorption_Homo sapiens_hsa049740.75300525
85Cocaine addiction_Homo sapiens_hsa050300.75084404
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74144274
87Endocytosis_Homo sapiens_hsa041440.73399190
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.73298804
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72878348
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.72750537
91Gastric acid secretion_Homo sapiens_hsa049710.71719277
92Melanoma_Homo sapiens_hsa052180.71486215
93Arachidonic acid metabolism_Homo sapiens_hsa005900.70553709
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.70487969
95Peroxisome_Homo sapiens_hsa041460.69860764
96DNA replication_Homo sapiens_hsa030300.69761230
97N-Glycan biosynthesis_Homo sapiens_hsa005100.69685733
98Salivary secretion_Homo sapiens_hsa049700.69149617
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.68922743
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.68328186
101Arginine biosynthesis_Homo sapiens_hsa002200.68186756
102FoxO signaling pathway_Homo sapiens_hsa040680.68140072
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67620537
104Nucleotide excision repair_Homo sapiens_hsa034200.67279261
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66867171
106Lysosome_Homo sapiens_hsa041420.66093024
107Pathways in cancer_Homo sapiens_hsa052000.64868501
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64403162
109Synaptic vesicle cycle_Homo sapiens_hsa047210.64274926
110Ras signaling pathway_Homo sapiens_hsa040140.64103587
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.63264714
112Circadian entrainment_Homo sapiens_hsa047130.63238643
113Mineral absorption_Homo sapiens_hsa049780.62171799
114Ovarian steroidogenesis_Homo sapiens_hsa049130.60613031
115Renin-angiotensin system_Homo sapiens_hsa046140.60515031
116Platelet activation_Homo sapiens_hsa046110.60323794
117Prostate cancer_Homo sapiens_hsa052150.59523355
118Galactose metabolism_Homo sapiens_hsa000520.59110013
119Folate biosynthesis_Homo sapiens_hsa007900.59079704
120Cardiac muscle contraction_Homo sapiens_hsa042600.58707619
121Pancreatic secretion_Homo sapiens_hsa049720.57564038
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57182268
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57070972
124Phototransduction_Homo sapiens_hsa047440.56678984
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56495830
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55793798
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55583583
128Rheumatoid arthritis_Homo sapiens_hsa053230.54747662
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54371706
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54341097
131Cholinergic synapse_Homo sapiens_hsa047250.54288534
132Insulin signaling pathway_Homo sapiens_hsa049100.54058016
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53158054
134Dorso-ventral axis formation_Homo sapiens_hsa043200.52026778
135Dopaminergic synapse_Homo sapiens_hsa047280.51072908
136ErbB signaling pathway_Homo sapiens_hsa040120.50763675
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49846866
138Nicotine addiction_Homo sapiens_hsa050330.49408644
139B cell receptor signaling pathway_Homo sapiens_hsa046620.49268228
140Vitamin digestion and absorption_Homo sapiens_hsa049770.49140659
141Gap junction_Homo sapiens_hsa045400.49029786
142GnRH signaling pathway_Homo sapiens_hsa049120.48421336
143Hepatitis B_Homo sapiens_hsa051610.48278475
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.47505204
145Toxoplasmosis_Homo sapiens_hsa051450.46796024
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46127824
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45883229
148Retinol metabolism_Homo sapiens_hsa008300.45845586
149Fatty acid biosynthesis_Homo sapiens_hsa000610.45380456
150Chemical carcinogenesis_Homo sapiens_hsa052040.44986390
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44111104
152Shigellosis_Homo sapiens_hsa051310.43594980
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42755354
154Phagosome_Homo sapiens_hsa041450.40583330
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40225288
156Selenocompound metabolism_Homo sapiens_hsa004500.39695813
157Prion diseases_Homo sapiens_hsa050200.39148274
158Metabolic pathways_Homo sapiens_hsa011000.39123395
159Acute myeloid leukemia_Homo sapiens_hsa052210.38834910
160Autoimmune thyroid disease_Homo sapiens_hsa053200.38700680
161Fat digestion and absorption_Homo sapiens_hsa049750.38332163
162PPAR signaling pathway_Homo sapiens_hsa033200.37894488
163TNF signaling pathway_Homo sapiens_hsa046680.37268706
164Salmonella infection_Homo sapiens_hsa051320.37195788
165Rap1 signaling pathway_Homo sapiens_hsa040150.36994705
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36891007
167Bile secretion_Homo sapiens_hsa049760.36299451
168Legionellosis_Homo sapiens_hsa051340.35769185
169Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35489846
170Renin secretion_Homo sapiens_hsa049240.35372968
171Pyruvate metabolism_Homo sapiens_hsa006200.35310439
172Hedgehog signaling pathway_Homo sapiens_hsa043400.35149451
173ECM-receptor interaction_Homo sapiens_hsa045120.34873706
174beta-Alanine metabolism_Homo sapiens_hsa004100.34419969
175Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33467077
176Choline metabolism in cancer_Homo sapiens_hsa052310.33230388
177Glycerolipid metabolism_Homo sapiens_hsa005610.32719876
178Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31596545
179Taste transduction_Homo sapiens_hsa047420.31368971
180Huntingtons disease_Homo sapiens_hsa050160.31178329
181Olfactory transduction_Homo sapiens_hsa047400.30782979
182Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30061801

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