PLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.04105698
2sarcomere organization (GO:0045214)8.76641706
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.56993384
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.75435831
5myofibril assembly (GO:0030239)7.61912708
6tricarboxylic acid cycle (GO:0006099)7.26639290
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.97044388
8cardiac muscle contraction (GO:0060048)6.84387088
9* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.73424612
10cardiac muscle cell development (GO:0055013)6.54434546
11regulation of sarcomere organization (GO:0060297)6.44866700
12* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.36439869
13ventricular cardiac muscle cell action potential (GO:0086005)6.14786375
14cardiac cell development (GO:0055006)6.14245029
15bundle of His cell to Purkinje myocyte communication (GO:0086069)6.13660344
16cardiac muscle hypertrophy (GO:0003300)6.01978940
17regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.94438062
18* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.88466916
19cardiac muscle tissue morphogenesis (GO:0055008)5.74555450
20ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.70816775
21heart trabecula formation (GO:0060347)5.69589912
22muscle filament sliding (GO:0030049)5.68801102
23actin-myosin filament sliding (GO:0033275)5.68801102
24striated muscle hypertrophy (GO:0014897)5.67989944
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.54617096
26adult heart development (GO:0007512)5.51918482
27actomyosin structure organization (GO:0031032)5.49656607
28regulation of cell communication by electrical coupling (GO:0010649)5.49452713
29regulation of acyl-CoA biosynthetic process (GO:0050812)5.42418858
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.39793820
31cardiac chamber formation (GO:0003207)5.37423951
32carnitine shuttle (GO:0006853)5.33215890
33cell communication involved in cardiac conduction (GO:0086065)5.29596552
34* regulation of actin filament-based movement (GO:1903115)5.15435420
35muscle tissue morphogenesis (GO:0060415)5.09081370
36plasma membrane repair (GO:0001778)5.07285517
37heart process (GO:0003015)5.07057432
38heart contraction (GO:0060047)5.07057432
39muscle hypertrophy (GO:0014896)5.04241263
40regulation of membrane repolarization (GO:0060306)5.00520610
41regulation of coenzyme metabolic process (GO:0051196)4.95478410
42regulation of cofactor metabolic process (GO:0051193)4.95478410
43cardiac ventricle formation (GO:0003211)4.90951809
44striated muscle contraction (GO:0006941)4.88150146
45sarcoplasmic reticulum calcium ion transport (GO:0070296)4.85224838
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84451241
47* regulation of striated muscle contraction (GO:0006942)4.81846229
48fatty acid transmembrane transport (GO:1902001)4.77655905
49regulation of skeletal muscle contraction (GO:0014819)4.77001516
50actin-mediated cell contraction (GO:0070252)4.74410873
51cell communication by electrical coupling (GO:0010644)4.66790563
52* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.62175953
53* regulation of relaxation of muscle (GO:1901077)4.58209448
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57065942
55response to inactivity (GO:0014854)4.55599780
56energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53863471
57ATP synthesis coupled proton transport (GO:0015986)4.53863471
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.49385771
59respiratory electron transport chain (GO:0022904)4.46074995
60muscle contraction (GO:0006936)4.38935563
61cardiac muscle hypertrophy in response to stress (GO:0014898)4.36262495
62muscle hypertrophy in response to stress (GO:0003299)4.36262495
63cardiac muscle adaptation (GO:0014887)4.36262495
64skeletal muscle contraction (GO:0003009)4.33931713
65oxidative phosphorylation (GO:0006119)4.32861558
66electron transport chain (GO:0022900)4.32503478
67ventricular cardiac muscle cell development (GO:0055015)4.30132748
68cardiac muscle cell action potential involved in contraction (GO:0086002)4.29876124
69cardiac muscle cell action potential (GO:0086001)4.27611265
70* regulation of the force of heart contraction (GO:0002026)4.24344477
71* regulation of cardiac muscle contraction (GO:0055117)4.23572420
72negative regulation of potassium ion transport (GO:0043267)4.19692464
732-oxoglutarate metabolic process (GO:0006103)4.12574278
74negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.12288007
75regulation of sulfur metabolic process (GO:0042762)4.05289191
76positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.03608987
77NADH metabolic process (GO:0006734)4.02404566
78* muscle system process (GO:0003012)3.97723587
79response to caffeine (GO:0031000)3.97682913
80* regulation of heart rate (GO:0002027)3.97637990
81cellular response to epinephrine stimulus (GO:0071872)3.97027755
82response to epinephrine (GO:0071871)3.96561457
83carnitine transmembrane transport (GO:1902603)3.96022532
84regulation of cardioblast differentiation (GO:0051890)3.94348709
85striated muscle adaptation (GO:0014888)3.92157608
86regulation of heart rate by cardiac conduction (GO:0086091)3.77621675
87* regulation of heart contraction (GO:0008016)3.73241193
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.72766865
89creatine metabolic process (GO:0006600)3.70717252
90negative regulation of striated muscle cell apoptotic process (GO:0010664)3.70315469
91detection of calcium ion (GO:0005513)3.69707564
92atrial septum morphogenesis (GO:0060413)3.66939348
93* regulation of muscle contraction (GO:0006937)3.64458692
94negative regulation of protein localization to cell surface (GO:2000009)3.64157624
95regulation of sequestering of triglyceride (GO:0010889)3.62721738
96fatty acid beta-oxidation (GO:0006635)3.61543210
97amino-acid betaine transport (GO:0015838)3.60613966
98carnitine transport (GO:0015879)3.60613966
99trabecula formation (GO:0060343)3.58190169
100* relaxation of cardiac muscle (GO:0055119)3.57885336
101muscle fiber development (GO:0048747)3.57768153
102actin filament-based movement (GO:0030048)3.55244670
103aspartate family amino acid catabolic process (GO:0009068)3.53492899
104positive regulation of heart rate (GO:0010460)3.53392895
105positive regulation of cation channel activity (GO:2001259)3.52056179
106striated muscle cell development (GO:0055002)3.49684712
107* regulation of cardiac muscle cell contraction (GO:0086004)3.49594484
108muscle cell development (GO:0055001)3.48866208
109* regulation of muscle system process (GO:0090257)3.47363692
110positive regulation of heart contraction (GO:0045823)3.46819962
111* regulation of calcium ion transmembrane transport (GO:1903169)3.42425532
112* regulation of calcium ion transmembrane transporter activity (GO:1901019)3.42425532
113potassium ion export (GO:0071435)3.42221934
114regulation of fatty acid oxidation (GO:0046320)3.41927896
115succinate metabolic process (GO:0006105)3.38874883
116negative regulation of myotube differentiation (GO:0010832)3.37727605
117positive regulation of ATPase activity (GO:0032781)3.34091678
118positive regulation of ATP catabolic process (GO:1903291)3.34091678
119lysine metabolic process (GO:0006553)3.32563008
120lysine catabolic process (GO:0006554)3.32563008
121* cardiac conduction (GO:0061337)3.31416911
122* regulation of ATP catabolic process (GO:1903289)3.29557728
123* regulation of ATPase activity (GO:0043462)3.29557728
124atrioventricular valve morphogenesis (GO:0003181)3.27153348
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.25008378
126positive regulation of sodium ion transport (GO:0010765)3.24110228
127muscle adaptation (GO:0043500)3.13974359
128regulation of cardioblast proliferation (GO:0003264)3.08272303
129regulation of secondary heart field cardioblast proliferation (GO:0003266)3.08272303
130response to muscle activity (GO:0014850)3.08271654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.44317972
2* EP300_21415370_ChIP-Seq_HL-1_Mouse5.46307009
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.88850453
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.29579514
5* TBX20_22080862_ChIP-Seq_HEART_Mouse4.28887184
6* TBX20_22328084_ChIP-Seq_HEART_Mouse4.28887184
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14404284
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.38855336
9ZNF263_19887448_ChIP-Seq_K562_Human3.18530583
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.98222432
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.97555792
12GATA4_21415370_ChIP-Seq_HL-1_Mouse2.66890118
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55359944
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17619243
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15097010
16VDR_22108803_ChIP-Seq_LS180_Human2.14695472
17PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.13839871
18EZH2_22144423_ChIP-Seq_EOC_Human2.13697965
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08677161
20GATA1_22025678_ChIP-Seq_K562_Human2.04484234
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98499789
22NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.97410000
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92001423
24CLOCK_20551151_ChIP-Seq_293T_Human1.85965514
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74716277
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50704637
27GBX2_23144817_ChIP-Seq_PC3_Human1.47464481
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44271407
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42391250
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42324416
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40505147
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38628732
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.38611752
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35999045
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32587284
36SMAD4_21799915_ChIP-Seq_A2780_Human1.32074884
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.32027212
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30787282
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.29687513
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29514131
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29414220
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.28086211
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.27363631
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23562804
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23015043
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.21429128
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19112831
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16374699
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16044299
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.14906134
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12592347
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12592347
53GATA1_19941826_ChIP-Seq_K562_Human1.11581672
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11306104
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.07285905
56* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06454119
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05835713
58ZNF274_21170338_ChIP-Seq_K562_Hela1.03225876
59BCAT_22108803_ChIP-Seq_LS180_Human1.00827056
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00796654
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.00367661
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00153822
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00014840
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99407893
65* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98479277
66CBX2_27304074_Chip-Seq_ESCs_Mouse0.98360746
67DROSHA_22980978_ChIP-Seq_HELA_Human0.98271475
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98013568
69CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97738870
70AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97354975
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97088711
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.97070564
73WT1_19549856_ChIP-ChIP_CCG9911_Human0.96807439
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96802288
75ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96553262
76* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96401093
77CJUN_26792858_Chip-Seq_BT549_Human0.95905224
78BP1_19119308_ChIP-ChIP_Hs578T_Human0.95814592
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95092630
80* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94792064
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94430045
82TCF4_23295773_ChIP-Seq_U87_Human0.93915822
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93624614
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93596890
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92836451
86* EZH2_27294783_Chip-Seq_NPCs_Mouse0.92805343
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91423799
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91251495
89KDM2B_26808549_Chip-Seq_DND41_Human0.91210244
90RUNX1_27514584_Chip-Seq_MCF-7_Human0.90838420
91TP63_22573176_ChIP-Seq_HFKS_Human0.90740705
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.90473103
93TBL1_22424771_ChIP-Seq_293T_Human0.89366502
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87633778
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87520812
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86643549
97GF1_26923725_Chip-Seq_HPCs_Mouse0.85856900
98GATA2_19941826_ChIP-Seq_K562_Human0.85528890
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.85434250
100CTCF_27219007_Chip-Seq_Bcells_Human0.85293325
101ATF3_27146783_Chip-Seq_COLON_Human0.85277238
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85121588
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85118390
104TAF15_26573619_Chip-Seq_HEK293_Human0.84727214
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84664275
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84561710
107JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83992791
108* SMAD3_21741376_ChIP-Seq_EPCs_Human0.83953340
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83076113
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82925541
111* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81048444
112EED_16625203_ChIP-ChIP_MESCs_Mouse0.80739950
113* SMAD3_21741376_ChIP-Seq_HESCs_Human0.80580628
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.79943112
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79355514
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.78726216
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78500219
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78006519
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77914152
120SPI1_20517297_ChIP-Seq_HL60_Human0.76488828
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76301279
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76032702
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75597833
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.75516255
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75394386
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75277864
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74358151
128FOXH1_21741376_ChIP-Seq_ESCs_Human0.73790604
129RACK7_27058665_Chip-Seq_MCF-7_Human0.72783316
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72401696
131SPI1_23127762_ChIP-Seq_K562_Human0.71907643
132EGR1_19032775_ChIP-ChIP_M12_Human0.70707487
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.70065478
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.69791369
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69436128
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.68370590
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.68151726
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65830460
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65821870
140TP53_16413492_ChIP-PET_HCT116_Human0.65440966
141OCT4_20526341_ChIP-Seq_ESCs_Human0.65382659
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65316122
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64915042
144* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64787366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.67144350
2* MP0004084_abnormal_cardiac_muscle5.59460164
3MP0003646_muscle_fatigue5.38102026
4* MP0004215_abnormal_myocardial_fiber5.04430562
5MP0000751_myopathy4.92856098
6MP0005330_cardiomyopathy4.27817172
7* MP0004036_abnormal_muscle_relaxation3.88905409
8MP0000749_muscle_degeneration3.45634609
9MP0002972_abnormal_cardiac_muscle3.45268741
10MP0003137_abnormal_impulse_conducting3.24656634
11MP0004087_abnormal_muscle_fiber3.07105161
12MP0004484_altered_response_of2.90300660
13MP0010630_abnormal_cardiac_muscle2.85564892
14* MP0008775_abnormal_heart_ventricle2.84040194
15MP0004130_abnormal_muscle_cell2.79189725
16* MP0005385_cardiovascular_system_phenoty2.78379636
17* MP0001544_abnormal_cardiovascular_syste2.78379636
18MP0005620_abnormal_muscle_contractility2.74461061
19MP0000750_abnormal_muscle_regeneration2.65472450
20MP0006138_congestive_heart_failure2.64373650
21MP0003828_pulmonary_edema2.64065002
22MP0004085_abnormal_heartbeat2.44774141
23MP0002106_abnormal_muscle_physiology2.38511349
24MP0004510_myositis2.20759984
25MP0003221_abnormal_cardiomyocyte_apopto2.11736209
26MP0002269_muscular_atrophy2.09838119
27MP0005369_muscle_phenotype1.90200254
28MP0006036_abnormal_mitochondrial_physio1.88139583
29MP0002127_abnormal_cardiovascular_syste1.86739661
30MP0004145_abnormal_muscle_electrophysio1.79386061
31MP0000759_abnormal_skeletal_muscle1.71773104
32MP0000747_muscle_weakness1.68538549
33MP0003950_abnormal_plasma_membrane1.64327509
34MP0004233_abnormal_muscle_weight1.61495786
35MP0003567_abnormal_fetal_cardiomyocyte1.57708405
36MP0002332_abnormal_exercise_endurance1.39605205
37MP0005666_abnormal_adipose_tissue1.38500019
38MP0010368_abnormal_lymphatic_system1.36245537
39MP0005165_increased_susceptibility_to1.35847458
40MP0000343_altered_response_to1.32928937
41MP0000266_abnormal_heart_morphology1.26433589
42MP0003279_aneurysm1.20381975
43MP0001661_extended_life_span1.18089876
44MP0006035_abnormal_mitochondrial_morpho1.14358630
45MP0005670_abnormal_white_adipose1.11322840
46MP0002234_abnormal_pharynx_morphology1.09222615
47MP0005375_adipose_tissue_phenotype0.89793791
48MP0000230_abnormal_systemic_arterial0.89767768
49MP0004185_abnormal_adipocyte_glucose0.88764868
50MP0002128_abnormal_blood_circulation0.87680820
51MP0005623_abnormal_meninges_morphology0.86204331
52MP0003566_abnormal_cell_adhesion0.85341998
53MP0005266_abnormal_metabolism0.78961191
54MP0001879_abnormal_lymphatic_vessel0.78073391
55MP0003045_fibrosis0.73875808
56MP0004043_abnormal_pH_regulation0.73695604
57MP0002108_abnormal_muscle_morphology0.70408913
58MP0004272_abnormal_basement_membrane0.67619238
59MP0005503_abnormal_tendon_morphology0.67553406
60MP0000767_abnormal_smooth_muscle0.64414301
61MP0002909_abnormal_adrenal_gland0.64051104
62MP0004147_increased_porphyrin_level0.58526621
63MP0005451_abnormal_body_composition0.55934867
64MP0003705_abnormal_hypodermis_morpholog0.55229681
65MP0005187_abnormal_penis_morphology0.55118274
66MP0000003_abnormal_adipose_tissue0.54629327
67MP0003806_abnormal_nucleotide_metabolis0.53981171
68MP0009384_cardiac_valve_regurgitation0.52425397
69MP0002925_abnormal_cardiovascular_devel0.51301691
70MP0005319_abnormal_enzyme/_coenzyme0.51294340
71MP0008438_abnormal_cutaneous_collagen0.49754414
72MP0002078_abnormal_glucose_homeostasis0.49477812
73MP0000013_abnormal_adipose_tissue0.48814993
74MP0003984_embryonic_growth_retardation0.48005270
75MP0002971_abnormal_brown_adipose0.47240612
76MP0002088_abnormal_embryonic_growth/wei0.46915498
77MP0003941_abnormal_skin_development0.45025798
78MP0008004_abnormal_stomach_pH0.43479364
79MP0001614_abnormal_blood_vessel0.41715841
80MP0001784_abnormal_fluid_regulation0.41293285
81MP0005535_abnormal_body_temperature0.39467194
82MP0005275_abnormal_skin_tensile0.38365024
83MP0000733_abnormal_muscle_development0.38175253
84MP0000462_abnormal_digestive_system0.38001238
85MP0004924_abnormal_behavior0.37848680
86MP0005386_behavior/neurological_phenoty0.37848680
87MP0008961_abnormal_basal_metabolism0.37624568
88MP0002638_abnormal_pupillary_reflex0.35354739
89MP0005085_abnormal_gallbladder_physiolo0.34080322
90MP0001984_abnormal_olfaction0.32722946
91MP0005595_abnormal_vascular_smooth0.32162146
92MP0008569_lethality_at_weaning0.31935817
93MP0003136_yellow_coat_color0.31606019
94MP0001299_abnormal_eye_distance/0.31585599
95MP0005167_abnormal_blood-brain_barrier0.30176128
96MP0005248_abnormal_Harderian_gland0.29391330
97MP0003948_abnormal_gas_homeostasis0.28330797
98MP0005171_absent_coat_pigmentation0.28310641
99MP0001727_abnormal_embryo_implantation0.28196747
100MP0003195_calcinosis0.27803356
101MP0002118_abnormal_lipid_homeostasis0.27648691
102MP0002295_abnormal_pulmonary_circulatio0.26558101
103MP0005332_abnormal_amino_acid0.26467841
104MP0005388_respiratory_system_phenotype0.26342148
105MP0002133_abnormal_respiratory_system0.26342148
106MP0003878_abnormal_ear_physiology0.26271362
107MP0005377_hearing/vestibular/ear_phenot0.26271362
108MP0002822_catalepsy0.26124114
109MP0000249_abnormal_blood_vessel0.25710812
110MP0009780_abnormal_chondrocyte_physiolo0.25170893
111MP0001672_abnormal_embryogenesis/_devel0.25081866
112MP0005380_embryogenesis_phenotype0.25081866
113MP0005584_abnormal_enzyme/coenzyme_acti0.23987867
114MP0005409_darkened_coat_color0.22771467
115MP0008874_decreased_physiological_sensi0.22187288
116MP0002102_abnormal_ear_morphology0.18475149
117MP0009250_abnormal_appendicular_skeleto0.18451131
118MP0001958_emphysema0.17894693
119MP0000579_abnormal_nail_morphology0.17389522
120MP0000762_abnormal_tongue_morphology0.17300119
121MP0009115_abnormal_fat_cell0.16648067
122MP0000372_irregular_coat_pigmentation0.15162712
123MP0005334_abnormal_fat_pad0.14891368

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.52731934
2Ventricular tachycardia (HP:0004756)7.45025116
3* Atrial fibrillation (HP:0005110)6.36841072
4* Primary atrial arrhythmia (HP:0001692)5.94487260
5Muscle fiber inclusion bodies (HP:0100299)5.82503991
6Calf muscle hypertrophy (HP:0008981)5.80225720
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.76933117
8* Supraventricular tachycardia (HP:0004755)5.74104788
9Syncope (HP:0001279)5.68014880
10* Supraventricular arrhythmia (HP:0005115)5.62415365
11Nemaline bodies (HP:0003798)5.61899512
12Type 1 muscle fiber predominance (HP:0003803)5.59926264
13Right ventricular cardiomyopathy (HP:0011663)5.44992625
14* Lipoatrophy (HP:0100578)5.29438566
15Exercise-induced muscle cramps (HP:0003710)5.20871109
16Muscle hypertrophy of the lower extremities (HP:0008968)5.17633432
17Exercise-induced myalgia (HP:0003738)4.97432608
18Abnormality of the calf musculature (HP:0001430)4.96376984
19Muscle fiber splitting (HP:0003555)4.93901961
20Bundle branch block (HP:0011710)4.91084208
21Palpitations (HP:0001962)4.86238488
22Myoglobinuria (HP:0002913)4.83052631
23Subaortic stenosis (HP:0001682)4.78318060
24Abnormality of the left ventricular outflow tract (HP:0011103)4.78318060
25Prolonged QT interval (HP:0001657)4.70260992
26Centrally nucleated skeletal muscle fibers (HP:0003687)4.51716431
27* Dilated cardiomyopathy (HP:0001644)4.40564666
28Hyporeflexia of lower limbs (HP:0002600)4.36551830
29Ventricular fibrillation (HP:0001663)4.12671174
30Heart block (HP:0012722)4.12156418
31Atrioventricular block (HP:0001678)4.02060090
32* Ventricular arrhythmia (HP:0004308)4.01820964
33EMG: neuropathic changes (HP:0003445)3.93682605
34Asymmetric septal hypertrophy (HP:0001670)3.92532983
35Abnormal atrioventricular conduction (HP:0005150)3.87768757
36Rimmed vacuoles (HP:0003805)3.76791273
37Rhabdomyolysis (HP:0003201)3.63515538
38EMG: myopathic abnormalities (HP:0003458)3.56572036
39Hepatic necrosis (HP:0002605)3.44710354
40Abnormal mitochondria in muscle tissue (HP:0008316)3.41237492
41Abnormal EKG (HP:0003115)3.40070176
42Acute necrotizing encephalopathy (HP:0006965)3.34328153
43Increased connective tissue (HP:0009025)3.30793586
44Hypoglycemic coma (HP:0001325)3.28540320
45Ketoacidosis (HP:0001993)3.08641962
46Abnormality of skeletal muscle fiber size (HP:0012084)2.96527706
47Myotonia (HP:0002486)2.90825298
48Hepatocellular necrosis (HP:0001404)2.90226779
49Acute encephalopathy (HP:0006846)2.88739100
50Abnormality of fatty-acid metabolism (HP:0004359)2.86143635
51Difficulty running (HP:0009046)2.83866324
52Progressive macrocephaly (HP:0004481)2.81559680
53Dicarboxylic aciduria (HP:0003215)2.80705801
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80705801
55Generalized muscle weakness (HP:0003324)2.76240077
56Mildly elevated creatine phosphokinase (HP:0008180)2.74506531
57* Left ventricular hypertrophy (HP:0001712)2.74476382
58Cerebral edema (HP:0002181)2.72103861
59Mitochondrial inheritance (HP:0001427)2.68779297
60Conjunctival hamartoma (HP:0100780)2.64290647
61* Palmoplantar keratoderma (HP:0000982)2.61914902
62Increased CSF lactate (HP:0002490)2.60630786
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60183216
64Abnormality of alanine metabolism (HP:0010916)2.60183216
65Hyperalaninemia (HP:0003348)2.60183216
66Ragged-red muscle fibers (HP:0003200)2.58429919
67Increased muscle lipid content (HP:0009058)2.55625008
68Myopathic facies (HP:0002058)2.47264056
69Sudden cardiac death (HP:0001645)2.44864998
70Hip contracture (HP:0003273)2.44313429
71Difficulty climbing stairs (HP:0003551)2.39791906
72Pheochromocytoma (HP:0002666)2.39367685
73Distal arthrogryposis (HP:0005684)2.39359120
74Hypoplastic left heart (HP:0004383)2.38727944
75Lactic acidosis (HP:0003128)2.38631669
76Foot dorsiflexor weakness (HP:0009027)2.35477839
77Distal lower limb muscle weakness (HP:0009053)2.34879917
78Respiratory failure (HP:0002878)2.30342023
79Frequent falls (HP:0002359)2.28937521
80Scapular winging (HP:0003691)2.25907651
81Muscular dystrophy (HP:0003560)2.25188016
82Increased intramyocellular lipid droplets (HP:0012240)2.25185321
83Neoplasm of the adrenal gland (HP:0100631)2.23779177
84Exercise intolerance (HP:0003546)2.22954551
85Ketosis (HP:0001946)2.21637129
86Distal lower limb amyotrophy (HP:0008944)2.20121774
87Round ear (HP:0100830)2.19327112
88Bradycardia (HP:0001662)2.17787307
89Generalized aminoaciduria (HP:0002909)2.15431100
90Neuroendocrine neoplasm (HP:0100634)2.15229321
91Steppage gait (HP:0003376)2.13687803
92Increased serum pyruvate (HP:0003542)2.12437341
93Abnormality of glycolysis (HP:0004366)2.12437341
94Limb-girdle muscle atrophy (HP:0003797)2.10311327
95Hamartoma of the eye (HP:0010568)2.08854353
96Testicular atrophy (HP:0000029)2.08758445
97Toxemia of pregnancy (HP:0100603)2.07924487
98Areflexia of lower limbs (HP:0002522)2.07720275
99Hypoplastic heart (HP:0001961)2.07394357
100Progressive muscle weakness (HP:0003323)2.06173595
101Increased variability in muscle fiber diameter (HP:0003557)2.05669584
102Neoplasm of head and neck (HP:0012288)2.03769843
103Esophageal neoplasm (HP:0100751)2.03769843
104Muscle stiffness (HP:0003552)2.02354329
105Hyperinsulinemic hypoglycemia (HP:0000825)2.01630049
106Dysmetric saccades (HP:0000641)2.01602019
107Gowers sign (HP:0003391)2.00958770
108Hypoplastic ischia (HP:0003175)2.00086840
109Large for gestational age (HP:0001520)1.97031002
110Central scotoma (HP:0000603)1.95963468
111* Congestive heart failure (HP:0001635)1.94804846
112Nausea (HP:0002018)1.92028558
113Hyperammonemia (HP:0001987)1.90110310
114Congenital malformation of the right heart (HP:0011723)1.89709088
115Double outlet right ventricle (HP:0001719)1.89709088
116Lymphangioma (HP:0100764)1.89090002
117Lipid accumulation in hepatocytes (HP:0006561)1.88677398
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88569995
119Broad metatarsal (HP:0001783)1.87653127
120Abnormality of the shoulder girdle musculature (HP:0001435)1.86406611
121Abnormality of the foot musculature (HP:0001436)1.85737743
122Ulnar deviation of the wrist (HP:0003049)1.85324913
123Abnormality of the tricuspid valve (HP:0001702)1.84256767
124Neck muscle weakness (HP:0000467)1.80620016
125Athetosis (HP:0002305)1.80127081
126Tinnitus (HP:0000360)1.78041751
127Multiple enchondromatosis (HP:0005701)1.76268166
128Bulbar palsy (HP:0001283)1.75480562
129Hyperglycemia (HP:0003074)1.75121259
130Abnormality of the ischium (HP:0003174)1.74696570
131Limited hip movement (HP:0008800)1.73049444
132Proximal amyotrophy (HP:0007126)1.71970317
133Waddling gait (HP:0002515)1.66576341
134Diaphragmatic weakness (HP:0009113)1.63150674
135Lower limb amyotrophy (HP:0007210)1.61208613
136Absent phalangeal crease (HP:0006109)1.53531828
137Abnormality of the endocardium (HP:0004306)1.53278777
138Childhood onset (HP:0011463)1.50553579
139Calcaneovalgus deformity (HP:0001848)1.47679403
140Weak cry (HP:0001612)1.46079621
141Respiratory insufficiency due to muscle weakness (HP:0002747)1.45688670
142Periauricular skin pits (HP:0100277)1.45360262
143Preauricular pit (HP:0004467)1.45360262
144Skin pits (HP:0100276)1.43344106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.46231097
2LMTK24.31716038
3PDK44.08082707
4PDK34.08082707
5MYLK3.97185688
6PHKG23.69413927
7PHKG13.69413927
8PKN23.62704375
9OBSCN3.17713345
10DMPK3.03442097
11STK242.78719405
12TRIB32.60022663
13PDK22.51624774
14TIE12.50504244
15NEK12.41742653
16BCKDK2.37056747
17GRK72.19719655
18PIK3CA2.14268576
19PINK11.91620471
20MUSK1.81403523
21PAK31.52461060
22CAMK2D1.46000211
23ILK1.38515340
24PRKD11.38423249
25PIK3CG1.32590885
26WNK41.30786642
27INSRR1.19296042
28MARK11.17902458
29FLT31.14676013
30STK41.11069462
31CDC42BPA1.09793964
32ZAK1.00473015
33TRPM70.97548041
34MAP3K70.97436808
35ROCK10.97257230
36STK38L0.92695364
37MAPK120.89346024
38PRKAA20.85238411
39PRKAA10.84905060
40KDR0.80639861
41STK390.79250879
42DAPK30.78922369
43MAP3K60.78846129
44WNK10.77800726
45PDGFRA0.76634001
46MAP3K50.76389910
47RIPK10.71842776
48PKN10.69198166
49STK380.68956826
50TGFBR20.64717113
51MAPKAPK30.63642994
52NEK90.59100889
53NME20.58038821
54ROCK20.57390073
55MAPK40.54594968
56RPS6KL10.53373431
57RPS6KC10.53373431
58PTK2B0.51998279
59PRKCE0.51933615
60* CAMK2A0.51703684
61CAMK2B0.50224729
62PRKACB0.48860216
63MAP2K30.47773129
64EEF2K0.46384492
65RPS6KA60.44742593
66PDPK10.43795812
67MAP3K30.43375518
68EPHB10.43200708
69PDK10.42341463
70MAP2K10.39077355
71DDR20.38506971
72* PRKACA0.37628626
73MAP2K40.37482886
74* PRKACG0.34675942
75CAMK2G0.34658856
76DYRK1B0.32859363
77RET0.32662048
78PTK60.31640356
79ERBB30.30648525
80KSR20.30154353
81ITK0.28600371
82PRKCH0.28486586
83RPS6KA10.27805809
84NLK0.27278545
85AKT20.27038483
86ICK0.26941036
87PRKD30.25167764
88JAK10.24579935
89MAPK100.23980530
90LATS10.23321203
91RAF10.22435689
92AKT30.21781960
93SGK20.21389598
94PRKG20.20608825
95UHMK10.20203220
96LRRK20.20038750
97MAPK70.19185120
98PRKCQ0.18714335
99SGK30.18042176
100FER0.17618109
101* CAMK10.17053802
102FGFR40.16281873
103MAP3K100.15868136
104PDGFRB0.15617305
105LATS20.15504984
106PRKG10.14721024
107EPHB20.14518336
108RPS6KB20.14511534
109ADRBK10.14155398
110STK110.14140011
111SIK10.13775810
112MTOR0.13329913
113SGK10.12912718
114JAK20.12727274
115MAP2K60.12413192
116ZAP700.12061121
117RPS6KA30.11967361
118MAPK110.10881645
119FGFR30.10530823
120FGFR10.09541619
121MARK30.09408514
122EPHA30.09330288
123CDK50.08892503
124CCNB10.08597486
125TGFBR10.07774203
126MAP3K10.07715694
127PAK60.07134468
128LIMK10.06878420

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.30181050
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.39063431
3Cardiac muscle contraction_Homo sapiens_hsa042604.08541420
4Propanoate metabolism_Homo sapiens_hsa006403.51791463
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.35883367
6* Dilated cardiomyopathy_Homo sapiens_hsa054143.31554655
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28895359
8Parkinsons disease_Homo sapiens_hsa050123.28395526
9Fatty acid degradation_Homo sapiens_hsa000713.25690433
10Oxidative phosphorylation_Homo sapiens_hsa001903.18847438
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60498381
12Carbon metabolism_Homo sapiens_hsa012002.54583074
13Fatty acid metabolism_Homo sapiens_hsa012122.46867135
14Alzheimers disease_Homo sapiens_hsa050102.40304002
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.34561465
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.20323688
17Huntingtons disease_Homo sapiens_hsa050162.06263700
18Pyruvate metabolism_Homo sapiens_hsa006201.88376593
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63023991
20Butanoate metabolism_Homo sapiens_hsa006501.61176578
21Viral myocarditis_Homo sapiens_hsa054161.59676711
22Fatty acid elongation_Homo sapiens_hsa000621.58031160
23* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50321994
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38092057
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17531617
26PPAR signaling pathway_Homo sapiens_hsa033201.09877462
27Biosynthesis of amino acids_Homo sapiens_hsa012301.05191046
28Insulin resistance_Homo sapiens_hsa049311.01599237
29Adipocytokine signaling pathway_Homo sapiens_hsa049200.92514447
30Tryptophan metabolism_Homo sapiens_hsa003800.92362699
31Glucagon signaling pathway_Homo sapiens_hsa049220.90944919
32Starch and sucrose metabolism_Homo sapiens_hsa005000.85174270
33* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85119716
34beta-Alanine metabolism_Homo sapiens_hsa004100.84233352
35Lysine degradation_Homo sapiens_hsa003100.82423052
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79643814
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79174776
38Insulin signaling pathway_Homo sapiens_hsa049100.76775680
39Arginine biosynthesis_Homo sapiens_hsa002200.72737228
40HIF-1 signaling pathway_Homo sapiens_hsa040660.68237730
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64644049
42Focal adhesion_Homo sapiens_hsa045100.63924765
43Pentose phosphate pathway_Homo sapiens_hsa000300.63782654
44AMPK signaling pathway_Homo sapiens_hsa041520.60945095
45Type II diabetes mellitus_Homo sapiens_hsa049300.59019230
46Peroxisome_Homo sapiens_hsa041460.58707454
47* Calcium signaling pathway_Homo sapiens_hsa040200.58321654
48Arginine and proline metabolism_Homo sapiens_hsa003300.57608182
49Oxytocin signaling pathway_Homo sapiens_hsa049210.53342479
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.51246317
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47619973
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47405083
53Phenylalanine metabolism_Homo sapiens_hsa003600.46355921
54Fatty acid biosynthesis_Homo sapiens_hsa000610.45358414
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45057674
56Salivary secretion_Homo sapiens_hsa049700.44952513
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43905739
58Renin secretion_Homo sapiens_hsa049240.43874369
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.43553631
60ECM-receptor interaction_Homo sapiens_hsa045120.42582438
61Galactose metabolism_Homo sapiens_hsa000520.41671493
62Amphetamine addiction_Homo sapiens_hsa050310.36925555
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35407715
64Gastric acid secretion_Homo sapiens_hsa049710.34922775
65* cAMP signaling pathway_Homo sapiens_hsa040240.33969122
66Tight junction_Homo sapiens_hsa045300.33908385
67Long-term potentiation_Homo sapiens_hsa047200.33622033
68Adherens junction_Homo sapiens_hsa045200.32043010
69* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31481774
70Protein digestion and absorption_Homo sapiens_hsa049740.31172458
71Melanogenesis_Homo sapiens_hsa049160.30452422
72GABAergic synapse_Homo sapiens_hsa047270.30057363
73Endometrial cancer_Homo sapiens_hsa052130.29996210
74Insulin secretion_Homo sapiens_hsa049110.29771865
75Morphine addiction_Homo sapiens_hsa050320.27440662
76Mineral absorption_Homo sapiens_hsa049780.27368084
77Fructose and mannose metabolism_Homo sapiens_hsa000510.26342696
78Regulation of autophagy_Homo sapiens_hsa041400.26152630
79Metabolic pathways_Homo sapiens_hsa011000.25173132
80Amoebiasis_Homo sapiens_hsa051460.24931980
81Circadian entrainment_Homo sapiens_hsa047130.24913945
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23538236
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22448864
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.20551643
85Dorso-ventral axis formation_Homo sapiens_hsa043200.19114928
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18319772
87Thyroid hormone synthesis_Homo sapiens_hsa049180.18070937
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17674040
89Circadian rhythm_Homo sapiens_hsa047100.16626582
90Renal cell carcinoma_Homo sapiens_hsa052110.16082448
91MAPK signaling pathway_Homo sapiens_hsa040100.15714636
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.15353312
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.15036306
94Platelet activation_Homo sapiens_hsa046110.14605471
95Prion diseases_Homo sapiens_hsa050200.14278946
96Olfactory transduction_Homo sapiens_hsa047400.14118509
97Fat digestion and absorption_Homo sapiens_hsa049750.14036051
98Ovarian steroidogenesis_Homo sapiens_hsa049130.12899246
99Proteoglycans in cancer_Homo sapiens_hsa052050.11082480
100Tyrosine metabolism_Homo sapiens_hsa003500.10746245
101mTOR signaling pathway_Homo sapiens_hsa041500.09308835
102Cholinergic synapse_Homo sapiens_hsa047250.09114061
103Pancreatic secretion_Homo sapiens_hsa049720.08995160
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08942547
105Gap junction_Homo sapiens_hsa045400.08341878
106Taste transduction_Homo sapiens_hsa047420.06760850
107Toxoplasmosis_Homo sapiens_hsa051450.05934426
108VEGF signaling pathway_Homo sapiens_hsa043700.05328027
109Small cell lung cancer_Homo sapiens_hsa052220.05030849
110Bile secretion_Homo sapiens_hsa049760.04533141
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04254312
112Glycerolipid metabolism_Homo sapiens_hsa005610.03937578
113GnRH signaling pathway_Homo sapiens_hsa049120.03118296
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01431885
115Estrogen signaling pathway_Homo sapiens_hsa049150.00150101
116Rap1 signaling pathway_Homo sapiens_hsa04015-0.0348321
117FoxO signaling pathway_Homo sapiens_hsa04068-0.0184625
118PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0037637

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