PLOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.33724887
2COPI coating of Golgi vesicle (GO:0048205)5.33724887
3protein retention in ER lumen (GO:0006621)5.13233756
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.11451137
5peptidyl-proline hydroxylation (GO:0019511)4.49869819
6chondrocyte proliferation (GO:0035988)3.99822474
7protein hydroxylation (GO:0018126)3.99191285
8axon ensheathment in central nervous system (GO:0032291)3.97198920
9central nervous system myelination (GO:0022010)3.97198920
10retina vasculature morphogenesis in camera-type eye (GO:0061299)3.96690842
11hemidesmosome assembly (GO:0031581)3.74023761
12wound healing, spreading of epidermal cells (GO:0035313)3.66123636
13regulation of plasminogen activation (GO:0010755)3.65105496
14basement membrane organization (GO:0071711)3.58985505
15cell-substrate junction assembly (GO:0007044)3.56388599
16collagen fibril organization (GO:0030199)3.55163570
17regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.42765165
18extracellular fibril organization (GO:0043206)3.38182780
19barbed-end actin filament capping (GO:0051016)3.37273605
20protein maturation by protein folding (GO:0022417)3.36989313
21substrate-dependent cell migration (GO:0006929)3.36956189
22adhesion of symbiont to host cell (GO:0044650)3.35340839
23virion attachment to host cell (GO:0019062)3.35340839
24negative regulation of fibrinolysis (GO:0051918)3.34323379
25apoptotic cell clearance (GO:0043277)3.33997287
26axon ensheathment (GO:0008366)3.32996923
27ensheathment of neurons (GO:0007272)3.32996923
28import into cell (GO:0098657)3.31282828
29hyaluronan catabolic process (GO:0030214)3.30900758
30protein heterotrimerization (GO:0070208)3.30271641
31keratan sulfate catabolic process (GO:0042340)3.28627584
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28501491
33negative regulation of chondrocyte differentiation (GO:0032331)3.26937304
34adhesion of symbiont to host (GO:0044406)3.26934572
35low-density lipoprotein particle clearance (GO:0034383)3.26884066
36response to lipoprotein particle (GO:0055094)3.24527046
37vascular endothelial growth factor signaling pathway (GO:0038084)3.24017481
38myelination (GO:0042552)3.23772927
39glomerular filtration (GO:0003094)3.20160702
40positive regulation of blood vessel endothelial cell migration (GO:0043536)3.17730281
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16401973
42endothelial cell morphogenesis (GO:0001886)3.16363764
43collagen metabolic process (GO:0032963)3.16123620
44collagen catabolic process (GO:0030574)3.14755705
45fatty acid elongation (GO:0030497)3.14238488
46creatine metabolic process (GO:0006600)3.11436592
47regulation of early endosome to late endosome transport (GO:2000641)3.10456236
48type B pancreatic cell proliferation (GO:0044342)3.04491711
49regulation of extracellular matrix disassembly (GO:0010715)3.03182159
50cell migration involved in heart development (GO:0060973)3.00627974
51skin morphogenesis (GO:0043589)3.00524314
52regulation of sequestering of triglyceride (GO:0010889)2.99471753
53multicellular organismal macromolecule metabolic process (GO:0044259)2.96850527
54proline biosynthetic process (GO:0006561)2.93993971
55positive regulation of extracellular matrix organization (GO:1903055)2.93355551
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92833695
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.91385650
58adherens junction assembly (GO:0034333)2.90847001
59mesodermal cell differentiation (GO:0048333)2.90794957
60activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90227104
61endodermal cell differentiation (GO:0035987)2.89829545
62endocardial cushion development (GO:0003197)2.89084116
63multicellular organismal catabolic process (GO:0044243)2.88858882
64venous blood vessel morphogenesis (GO:0048845)2.88221861
65fibril organization (GO:0097435)2.88141210
66negative regulation of fatty acid transport (GO:2000192)2.86493816
67COPII vesicle coating (GO:0048208)2.86298489
68pinocytosis (GO:0006907)2.86140166
69plasma lipoprotein particle clearance (GO:0034381)2.85741170
70wound healing, spreading of cells (GO:0044319)2.85707968
71myelination in peripheral nervous system (GO:0022011)2.85304171
72peripheral nervous system axon ensheathment (GO:0032292)2.85304171
73positive regulation of osteoblast proliferation (GO:0033690)2.83869544
74stress fiber assembly (GO:0043149)2.83488130
75sequestering of extracellular ligand from receptor (GO:0035581)2.82496177
76glomerular basement membrane development (GO:0032836)2.82048314
77leukocyte migration involved in inflammatory response (GO:0002523)2.81631219
78multicellular organismal metabolic process (GO:0044236)2.80103364
79positive regulation of endothelial cell apoptotic process (GO:2000353)2.79904052
80cell-substrate adherens junction assembly (GO:0007045)2.79324822
81focal adhesion assembly (GO:0048041)2.79324822
82renal filtration (GO:0097205)2.77885694
83vesicle coating (GO:0006901)2.76955388
84positive regulation of nuclease activity (GO:0032075)2.75984421
85cell adhesion mediated by integrin (GO:0033627)2.75381949
86embryo implantation (GO:0007566)2.74008598
87blood vessel maturation (GO:0001955)2.73642770
88regulation of lipoprotein metabolic process (GO:0050746)2.72740705
89negative regulation of smooth muscle cell migration (GO:0014912)2.71487854
90substrate adhesion-dependent cell spreading (GO:0034446)2.71080717
91extracellular matrix disassembly (GO:0022617)2.69285993
92platelet degranulation (GO:0002576)2.68567017
93positive regulation of p38MAPK cascade (GO:1900745)2.68004778
94peptidyl-glutamic acid carboxylation (GO:0017187)2.67544561
95protein carboxylation (GO:0018214)2.67544561
96regulation of fibrinolysis (GO:0051917)2.65710949
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65504919
98negative regulation of protein localization to cell surface (GO:2000009)2.65438031
99complement activation, alternative pathway (GO:0006957)2.65343774
100membrane raft organization (GO:0031579)2.65094751
101positive regulation of collagen biosynthetic process (GO:0032967)2.63641812
102protein localization to endosome (GO:0036010)2.62713254
103bone trabecula formation (GO:0060346)2.62212539
104endoplasmic reticulum unfolded protein response (GO:0030968)2.61922232
105cochlea morphogenesis (GO:0090103)2.61587808
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61504381
107myelin maintenance (GO:0043217)2.61492343
108cell migration involved in sprouting angiogenesis (GO:0002042)2.60819811
109epithelial cell-cell adhesion (GO:0090136)2.60669557
110heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.60661162
111tooth mineralization (GO:0034505)2.57978371
112craniofacial suture morphogenesis (GO:0097094)2.57624202
113regulation of cholesterol storage (GO:0010885)2.55480510
114hypotonic response (GO:0006971)2.55435435
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55346787
116alpha-linolenic acid metabolic process (GO:0036109)2.54617097
117cardiac myofibril assembly (GO:0055003)2.54066053
118interleukin-6-mediated signaling pathway (GO:0070102)2.53680246
119endothelial cell chemotaxis (GO:0035767)2.52533995
120muscle cell migration (GO:0014812)2.52108755
121blood vessel endothelial cell migration (GO:0043534)2.51742124
122positive regulation by symbiont of host defense response (GO:0052509)2.51381376
123modulation by symbiont of host defense response (GO:0052031)2.51381376
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51381376
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51381376
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.51381376
127modulation by symbiont of host immune response (GO:0052553)2.51381376
128iron ion import (GO:0097286)2.50040576
129extracellular matrix assembly (GO:0085029)2.49161901
130kidney mesenchyme development (GO:0072074)2.49056284
131positive regulation of receptor recycling (GO:0001921)2.48765100
132positive regulation of endothelial cell migration (GO:0010595)2.48689953
133actin filament depolymerization (GO:0030042)2.46864551
134regulation of p38MAPK cascade (GO:1900744)2.44832031
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44180142
136L-phenylalanine catabolic process (GO:0006559)2.44180142
137regulation of complement activation (GO:0030449)2.43854787
138lymphangiogenesis (GO:0001946)2.42423303
139trabecula formation (GO:0060343)2.41788091
140mannose metabolic process (GO:0006013)2.40480808
141response to methylmercury (GO:0051597)2.40420067
142cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40361985
143cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.40179845
144semaphorin-plexin signaling pathway (GO:0071526)2.39268561
1454-hydroxyproline metabolic process (GO:0019471)2.38120701
146regulation of protein activation cascade (GO:2000257)2.38089902
147pathway-restricted SMAD protein phosphorylation (GO:0060389)2.35799542
148myofibril assembly (GO:0030239)2.35705216
149heart trabecula formation (GO:0060347)2.34365794
150branching involved in salivary gland morphogenesis (GO:0060445)2.34283005
151fibrinolysis (GO:0042730)2.34215824
152cortical actin cytoskeleton organization (GO:0030866)2.33136132
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.32321686
154amyloid precursor protein catabolic process (GO:0042987)2.32220952
155astrocyte development (GO:0014002)2.32168613
156lymph vessel development (GO:0001945)2.31193471
157cholesterol biosynthetic process (GO:0006695)2.31134824
158amyloid precursor protein metabolic process (GO:0042982)2.30876882
159heme transport (GO:0015886)2.29861905
160dermatan sulfate biosynthetic process (GO:0030208)2.28603152
161regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27701311
162fatty-acyl-CoA biosynthetic process (GO:0046949)2.27254017
163platelet-derived growth factor receptor signaling pathway (GO:0048008)2.25688563
164positive regulation of smooth muscle cell migration (GO:0014911)2.25386249
165response to laminar fluid shear stress (GO:0034616)2.24664832
166fatty acid beta-oxidation (GO:0006635)2.24313574
167* extracellular matrix organization (GO:0030198)2.23736472
168* extracellular structure organization (GO:0043062)2.22728708
169opsonization (GO:0008228)2.22598239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.56537922
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.78602695
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65292354
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97423455
5* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.80442231
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.74222332
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.72277024
8CLOCK_20551151_ChIP-Seq_293T_Human2.55433028
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51566807
10ZNF263_19887448_ChIP-Seq_K562_Human2.50202826
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.44215890
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32168779
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.30499810
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29394084
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.17480017
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.00933062
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.96913951
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94389464
19GATA2_21666600_ChIP-Seq_HMVEC_Human1.87937067
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87687368
21NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84539940
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84539940
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84076079
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83385337
25* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.81110084
26TP53_22127205_ChIP-Seq_IMR90_Human1.79937989
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.79812156
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78577526
29CJUN_26792858_Chip-Seq_BT549_Human1.77799150
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71233073
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.70506712
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.70506712
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70398287
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69654568
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68519760
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67833690
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62355351
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.59281124
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58604243
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55544560
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55045455
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53642818
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.52542708
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52524723
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51486465
46ATF3_27146783_Chip-Seq_COLON_Human1.51296186
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49540474
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48539375
49KDM2B_26808549_Chip-Seq_K562_Human1.47670019
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41273123
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41206304
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40689011
53* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38494294
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.35693573
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.35319471
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33288377
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32794030
58AR_21572438_ChIP-Seq_LNCaP_Human1.32673679
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32387741
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32362652
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30959782
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30221543
63* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29738881
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27886893
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27886893
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.27849927
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.27131491
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25305594
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24527293
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24433420
71VDR_24787735_ChIP-Seq_THP-1_Human1.24311091
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.24305361
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24132275
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23864117
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23519768
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.23352275
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22663027
78SOX2_20726797_ChIP-Seq_SW620_Human1.20830018
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19542884
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18512275
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18195127
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17802870
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17337609
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16293198
85TP53_23651856_ChIP-Seq_MEFs_Mouse1.15780194
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.15240277
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14534917
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14060982
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13413931
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13381632
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13371130
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13247806
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12220657
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.10654774
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10062739
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09068746
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07480877
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05734444
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05450470
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04827670
101GATA1_19941826_ChIP-Seq_K562_Human1.03821371
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03700284
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.03494054
104* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03401582
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02410969
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02347548
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01535509
108* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01208252
109* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98612949
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97908597
111KDM2B_26808549_Chip-Seq_DND41_Human0.96719236
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96667022
113AR_21909140_ChIP-Seq_LNCAP_Human0.96187874
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96001406
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94649112
116* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93795301
117* RACK7_27058665_Chip-Seq_MCF-7_Human0.93435804
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92832840
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92716648
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.92520121
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.92036558
122SA1_22415368_ChIP-Seq_MEFs_Mouse0.92003787
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91103316
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90728288
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90364548
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89978442
127LXR_22292898_ChIP-Seq_THP-1_Human0.89429533
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88886061
129BRD4_25478319_ChIP-Seq_HGPS_Human0.88726003
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85487318
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84489277
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84489277
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84009768
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82967446
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82827055
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82629577
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81678240
138SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81558592
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81503586
140* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81242445
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79633010
142* UBF1/2_26484160_Chip-Seq_HMECs_Human0.79408214
143TP53_16413492_ChIP-PET_HCT116_Human0.79306064
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79129476
145CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78115416
146AHR_22903824_ChIP-Seq_MCF-7_Human0.77897255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen6.17150429
2MP0005503_abnormal_tendon_morphology3.40956414
3MP0004272_abnormal_basement_membrane3.25378053
4MP0005275_abnormal_skin_tensile3.18888524
5MP0005058_abnormal_lysosome_morphology2.66459534
6MP0003950_abnormal_plasma_membrane2.58637404
7MP0003279_aneurysm2.54421070
8MP0001958_emphysema2.41238722
9MP0009840_abnormal_foam_cell2.41173291
10MP0003705_abnormal_hypodermis_morpholog2.35266445
11MP0010368_abnormal_lymphatic_system2.29758761
12MP0005171_absent_coat_pigmentation2.29009180
13MP0000920_abnormal_myelination2.28365919
14MP0010030_abnormal_orbit_morphology2.26989810
15MP0000751_myopathy2.09644308
16MP0003690_abnormal_glial_cell2.05811416
17MP0005670_abnormal_white_adipose2.03416513
18MP0002877_abnormal_melanocyte_morpholog2.01758853
19MP0004084_abnormal_cardiac_muscle1.94781957
20MP0004858_abnormal_nervous_system1.90853445
21MP0006054_spinal_hemorrhage1.88261717
22MP0003191_abnormal_cellular_cholesterol1.77642007
23MP0002837_dystrophic_cardiac_calcinosis1.67817705
24MP0005623_abnormal_meninges_morphology1.67310444
25MP0003566_abnormal_cell_adhesion1.65844399
26MP0001849_ear_inflammation1.64334200
27MP0002295_abnormal_pulmonary_circulatio1.63780250
28MP0009384_cardiac_valve_regurgitation1.60924997
29MP0001879_abnormal_lymphatic_vessel1.58255571
30MP0000749_muscle_degeneration1.56853307
31MP0004036_abnormal_muscle_relaxation1.53825174
32MP0002933_joint_inflammation1.53803951
33MP0005508_abnormal_skeleton_morphology1.53415987
34MP0004185_abnormal_adipocyte_glucose1.52598662
35MP0005257_abnormal_intraocular_pressure1.52200809
36MP0009780_abnormal_chondrocyte_physiolo1.46944831
37MP0002108_abnormal_muscle_morphology1.46455164
38MP0004233_abnormal_muscle_weight1.43820960
39MP0003172_abnormal_lysosome_physiology1.42531029
40MP0000343_altered_response_to1.39829435
41MP0005666_abnormal_adipose_tissue1.39485202
42MP0003724_increased_susceptibility_to1.39205188
43MP0005330_cardiomyopathy1.38663534
44MP0004130_abnormal_muscle_cell1.33353738
45MP0009053_abnormal_anal_canal1.28789724
46MP0000534_abnormal_ureter_morphology1.28471244
47MP0003385_abnormal_body_wall1.27894202
48MP0000750_abnormal_muscle_regeneration1.24037816
49MP0005375_adipose_tissue_phenotype1.23073000
50MP0005409_darkened_coat_color1.22321072
51MP0006082_CNS_inflammation1.22190701
52MP0005451_abnormal_body_composition1.20830878
53MP0004134_abnormal_chest_morphology1.18114690
54MP0005023_abnormal_wound_healing1.18044932
55MP0002139_abnormal_hepatobiliary_system1.17642668
56MP0001533_abnormal_skeleton_physiology1.17294014
57MP0004087_abnormal_muscle_fiber1.16184101
58* MP0000767_abnormal_smooth_muscle1.15037088
59MP0000762_abnormal_tongue_morphology1.14599258
60MP0000733_abnormal_muscle_development1.14149220
61MP0000003_abnormal_adipose_tissue1.13013659
62MP0003942_abnormal_urinary_system1.12770483
63MP0003091_abnormal_cell_migration1.11896690
64MP0005360_urolithiasis1.11648391
65MP0003634_abnormal_glial_cell1.10611543
66MP0003941_abnormal_skin_development1.09815226
67MP0006138_congestive_heart_failure1.08889707
68MP0005390_skeleton_phenotype1.07251429
69MP0001542_abnormal_bone_strength1.07155173
70MP0000013_abnormal_adipose_tissue1.06744584
71MP0008775_abnormal_heart_ventricle1.06375018
72MP0005164_abnormal_response_to1.05635717
73MP0003828_pulmonary_edema1.05619407
74* MP0002060_abnormal_skin_morphology1.04456825
75MP0008260_abnormal_autophagy1.04421375
76MP0001348_abnormal_lacrimal_gland1.04153208
77MP0003300_gastrointestinal_ulcer1.03974222
78MP0000747_muscle_weakness1.03577406
79MP0002089_abnormal_postnatal_growth/wei1.02839504
80MP0002972_abnormal_cardiac_muscle1.02636816
81MP0003195_calcinosis1.01900698
82MP0001661_extended_life_span1.00133549
83MP0002998_abnormal_bone_remodeling0.99718069
84MP0000604_amyloidosis0.99544443
85MP0003252_abnormal_bile_duct0.97847318
86MP0010352_gastrointestinal_tract_polyps0.97701500
87MP0003136_yellow_coat_color0.97168402
88MP0010630_abnormal_cardiac_muscle0.96549550
89MP0005165_increased_susceptibility_to0.96057619
90MP0000858_altered_metastatic_potential0.95722874
91MP0005595_abnormal_vascular_smooth0.93395343
92MP0005385_cardiovascular_system_phenoty0.91917719
93MP0001544_abnormal_cardiovascular_syste0.91917719
94MP0005076_abnormal_cell_differentiation0.91286461
95MP0003075_altered_response_to0.91204112
96MP0001243_abnormal_dermal_layer0.91023914
97* MP0002128_abnormal_blood_circulation0.90162561
98MP0003806_abnormal_nucleotide_metabolis0.90051997
99MP0003045_fibrosis0.89386042
100MP0002118_abnormal_lipid_homeostasis0.88951387
101MP0001851_eye_inflammation0.87451817
102MP0004215_abnormal_myocardial_fiber0.85781717
103MP0002896_abnormal_bone_mineralization0.85762640
104MP0001299_abnormal_eye_distance/0.85626452
105* MP0001614_abnormal_blood_vessel0.85440179
106MP0010329_abnormal_lipoprotein_level0.84100916
107MP0000249_abnormal_blood_vessel0.83492968
108MP0005369_muscle_phenotype0.80136749
109MP0002932_abnormal_joint_morphology0.79597991
110MP0000163_abnormal_cartilage_morphology0.78961116
111MP0005620_abnormal_muscle_contractility0.78577662
112MP0001915_intracranial_hemorrhage0.78538664
113MP0000759_abnormal_skeletal_muscle0.78493401
114MP0000678_abnormal_parathyroid_gland0.78489787
115MP0000428_abnormal_craniofacial_morphol0.78162517
116MP0002113_abnormal_skeleton_development0.77845099
117MP0000537_abnormal_urethra_morphology0.77539923
118MP0009250_abnormal_appendicular_skeleto0.77446700
119MP0005167_abnormal_blood-brain_barrier0.77373865
120MP0002115_abnormal_skeleton_extremities0.76074371
121MP0005193_abnormal_anterior_eye0.75047343
122MP0000467_abnormal_esophagus_morphology0.74393155
123MP0002282_abnormal_trachea_morphology0.74046362
124MP0005365_abnormal_bile_salt0.73185471
125MP0003448_altered_tumor_morphology0.72191364
126MP0005197_abnormal_uvea_morphology0.72068280
127MP0003303_peritoneal_inflammation0.71483884
128MP0003329_amyloid_beta_deposits0.70480842
129MP0002106_abnormal_muscle_physiology0.70426409
130MP0005408_hypopigmentation0.70269988
131MP0002925_abnormal_cardiovascular_devel0.69817976
132MP0003115_abnormal_respiratory_system0.69574801
133MP0003453_abnormal_keratinocyte_physiol0.65147303
134MP0000432_abnormal_head_morphology0.63294715
135MP0003755_abnormal_palate_morphology0.61321144
136MP0002697_abnormal_eye_size0.60256372
137MP0002092_abnormal_eye_morphology0.60045595
138MP0001175_abnormal_lung_morphology0.59231049
139MP0000462_abnormal_digestive_system0.59201109
140MP0005621_abnormal_cell_physiology0.58984800

Predicted human phenotypes

RankGene SetZ-score
1* Premature rupture of membranes (HP:0001788)5.17950566
2Protrusio acetabuli (HP:0003179)5.09104302
3Broad metatarsal (HP:0001783)4.44563545
4Systemic lupus erythematosus (HP:0002725)3.65496050
5Ankle contracture (HP:0006466)3.51945325
6Cerebral aneurysm (HP:0004944)3.37491554
7Muscle fiber splitting (HP:0003555)3.31721667
8Shallow orbits (HP:0000586)3.28083793
9Complement deficiency (HP:0004431)3.16237027
10Axonal loss (HP:0003447)3.06034808
11Peritonitis (HP:0002586)3.00896224
12Biconcave vertebral bodies (HP:0004586)2.97818827
13Hypoplastic ischia (HP:0003175)2.97197542
14Follicular hyperkeratosis (HP:0007502)2.90308664
15Cervical subluxation (HP:0003308)2.90201494
16Genu recurvatum (HP:0002816)2.86871106
17Increased cerebral lipofuscin (HP:0011813)2.85599983
18* Aortic dissection (HP:0002647)2.77673635
19Increased connective tissue (HP:0009025)2.76490905
20Hyporeflexia of lower limbs (HP:0002600)2.75906527
21Dilatation of the ascending aorta (HP:0005111)2.70452548
22Type 1 muscle fiber predominance (HP:0003803)2.70218742
23Neurofibrillary tangles (HP:0002185)2.70059418
24Abnormality of the ischium (HP:0003174)2.69464680
25Elbow flexion contracture (HP:0002987)2.68780136
26Nonimmune hydrops fetalis (HP:0001790)2.67432625
27Dysostosis multiplex (HP:0000943)2.67319693
28Glomerulonephritis (HP:0000099)2.62991578
29Mildly elevated creatine phosphokinase (HP:0008180)2.60756124
30Deep venous thrombosis (HP:0002625)2.59251848
31Vertebral compression fractures (HP:0002953)2.59102917
32Asymmetric septal hypertrophy (HP:0001670)2.58871289
33Atrophic scars (HP:0001075)2.57084971
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.54534049
35* Soft skin (HP:0000977)2.54029551
36Xanthomatosis (HP:0000991)2.53569934
37Achilles tendon contracture (HP:0001771)2.52241087
38Spinal rigidity (HP:0003306)2.48802377
39Abnormality of complement system (HP:0005339)2.48120912
40Upper limb amyotrophy (HP:0009129)2.46498976
41Distal upper limb amyotrophy (HP:0007149)2.46498976
42Abnormality of the Achilles tendon (HP:0005109)2.42471057
43Vascular tortuosity (HP:0004948)2.42299516
44Aortic aneurysm (HP:0004942)2.40746405
45* Blue sclerae (HP:0000592)2.40000371
46Wormian bones (HP:0002645)2.39436438
47Mitral stenosis (HP:0001718)2.39066978
48Arterial tortuosity (HP:0005116)2.37548062
49Hyperlipoproteinemia (HP:0010980)2.35972498
50Osteolytic defects of the hand bones (HP:0009699)2.35464105
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.35464105
52Mitral regurgitation (HP:0001653)2.35236274
53Increased variability in muscle fiber diameter (HP:0003557)2.35227802
54Myocardial infarction (HP:0001658)2.34138421
55* Abnormal delivery (HP:0001787)2.33632912
56* Joint laxity (HP:0001388)2.33197291
57Mitral valve prolapse (HP:0001634)2.31429775
58Short nail (HP:0001799)2.30384972
59Ovoid vertebral bodies (HP:0003300)2.28302662
60* Hyperextensible skin (HP:0000974)2.26703056
61Hypoplasia of the iris (HP:0007676)2.25920005
62Bowel diverticulosis (HP:0005222)2.23330376
63Neonatal short-limb short stature (HP:0008921)2.21689088
64Fragile skin (HP:0001030)2.21511560
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20677724
66Exercise-induced muscle cramps (HP:0003710)2.20428855
67Amyloidosis (HP:0011034)2.19895961
68Abnormality of dentin (HP:0010299)2.19657548
69Epiphyseal dysplasia (HP:0002656)2.19148481
70Vacuolated lymphocytes (HP:0001922)2.17917788
71Coxa vara (HP:0002812)2.17773167
72Mucopolysacchariduria (HP:0008155)2.15744534
73Urinary glycosaminoglycan excretion (HP:0003541)2.15744534
74Renal duplication (HP:0000075)2.15234760
75Skin nodule (HP:0200036)2.14668793
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14302066
77Slender build (HP:0001533)2.13359717
78Hand muscle atrophy (HP:0009130)2.08750639
79Natal tooth (HP:0000695)2.07298181
80Abnormality of carpal bone ossification (HP:0006257)2.06775437
81Abnormality of glycolipid metabolism (HP:0010969)2.06553553
82Abnormality of liposaccharide metabolism (HP:0010968)2.06553553
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.06553553
84Breech presentation (HP:0001623)2.05675937
85Short hallux (HP:0010109)2.04651727
86Protuberant abdomen (HP:0001538)2.04233009
87Ventricular tachycardia (HP:0004756)2.03587877
88Hyperacusis (HP:0010780)2.02624044
89Osteoarthritis (HP:0002758)2.02230394
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01438900
91Abnormality of polysaccharide metabolism (HP:0011012)2.01438900
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01438900
93Joint stiffness (HP:0001387)2.00757867
94Bell-shaped thorax (HP:0001591)2.00273147
95Coronal craniosynostosis (HP:0004440)1.99455265
96Peripheral demyelination (HP:0011096)1.98560684
97Sudden death (HP:0001699)1.98334838
98Difficulty running (HP:0009046)1.97963076
99Intrahepatic cholestasis (HP:0001406)1.97923984
100Abnormality of skeletal muscle fiber size (HP:0012084)1.97059150
101Hypoalphalipoproteinemia (HP:0003233)1.96845043
102Lipoatrophy (HP:0100578)1.96009725
103Onion bulb formation (HP:0003383)1.95730967
104Ectopia lentis (HP:0001083)1.94185431
105Cholecystitis (HP:0001082)1.92922762
106Abnormal gallbladder physiology (HP:0012438)1.92922762
107Cerebral inclusion bodies (HP:0100314)1.92753011
108Wrist flexion contracture (HP:0001239)1.92100170
109Abnormal ossification of hand bones (HP:0005921)1.91895727
110Aortic regurgitation (HP:0001659)1.91253511
111Aneurysm (HP:0002617)1.91019142
112Venous abnormality (HP:0002624)1.90807409
113Protruding ear (HP:0000411)1.90411475
114Cardiovascular calcification (HP:0011915)1.89334949
115Turricephaly (HP:0000262)1.88748878
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88522061
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.88522061
118* Disproportionate tall stature (HP:0001519)1.88341767
119Ulnar bowing (HP:0003031)1.88147599
120Generalized amyotrophy (HP:0003700)1.87387043
121Hypoventilation (HP:0002791)1.87223424
122Infantile muscular hypotonia (HP:0008947)1.86436385
123* Bladder diverticulum (HP:0000015)1.86188378
124Scapular winging (HP:0003691)1.85784978
125Pterygium (HP:0001059)1.84766577
126Round ear (HP:0100830)1.84184145
127Cupped ribs (HP:0000887)1.84158499
128Pulmonary artery stenosis (HP:0004415)1.84117969
129Thin bony cortex (HP:0002753)1.83444915
130Wide anterior fontanel (HP:0000260)1.83401745
131Nuclear cataract (HP:0100018)1.82431733
132Spondylolisthesis (HP:0003302)1.81083174
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.80608379
134Loss of speech (HP:0002371)1.80378942
135Abnormality of the acetabulum (HP:0003170)1.80113342
136Platyspondyly (HP:0000926)1.79676366
137* Inguinal hernia (HP:0000023)1.77774642
138Back pain (HP:0003418)1.76932650
139Flat acetabular roof (HP:0003180)1.76866727
140Venous insufficiency (HP:0005293)1.76823914
141Osteopenia (HP:0000938)1.75692871
142Trismus (HP:0000211)1.75169506
143Bowing of the arm (HP:0006488)1.74568499
144Bowed forearm bones (HP:0003956)1.74568499
145Camptodactyly of toe (HP:0001836)1.73811395
146Overgrowth (HP:0001548)1.72161285
147Long toe (HP:0010511)1.71719556
148Congenital glaucoma (HP:0001087)1.70279186
149Femoral bowing (HP:0002980)1.69903882
150J-shaped sella turcica (HP:0002680)1.67891949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.89013006
2TTN3.18598162
3TGFBR23.14799245
4STK392.78897641
5KDR2.75706743
6DDR22.71505397
7ERN12.71412117
8TRIB32.59509753
9TIE12.56339777
10EPHA22.53215874
11TESK12.32519972
12MET2.31993949
13IRAK32.18063287
14SIK12.01558645
15PDGFRA1.99439333
16LATS21.94151053
17PKN21.88026189
18DMPK1.71701256
19SMG11.71120058
20CAMK1D1.68446735
21PKN11.67907035
22ICK1.65191626
23PBK1.60555721
24EEF2K1.58089789
25NME21.56106980
26CAMK1G1.55341103
27FGFR21.45390576
28BCKDK1.40873679
29TRPM71.34475517
30BMX1.31571181
31ARAF1.29044127
32PHKG11.29016783
33PHKG21.29016783
34OXSR11.27880575
35PRKD11.27481421
36WNK41.19175375
37WNK11.18193124
38FGFR41.15366439
39CDC42BPA1.14759428
40PTK61.14174134
41CDK121.14125658
42PAK21.12133186
43PIM21.10979978
44LATS11.10026942
45KSR21.09166875
46CSK1.08123779
47KIT1.05629765
48TAOK21.05005547
49EPHA31.04835663
50LMTK21.04730371
51ROCK21.04199469
52MYLK1.00859912
53INSRR0.98611532
54MAPK150.98208842
55STK380.97596048
56NEK90.96827999
57PDGFRB0.94773418
58TBK10.94078326
59JAK10.93333429
60RIPK10.92883952
61FGR0.91744701
62MAPKAPK50.90733112
63OBSCN0.89765615
64PAK40.88692094
65EPHB20.87390541
66PTK2B0.85846974
67PAK30.84652427
68CLK10.82212433
69GSK3A0.82068424
70MAP3K30.81136808
71MAP3K60.79826721
72MAPKAPK30.77646432
73RPS6KA20.77406945
74MAP3K80.76886742
75MST1R0.75060918
76CSF1R0.74685102
77PRPF4B0.74292255
78CDK80.74049136
79ILK0.73240432
80ROCK10.73004492
81TYK20.72260875
82DAPK30.69998713
83MAP2K30.69770211
84PIK3CA0.69546141
85TESK20.69145515
86PRKAA20.68818708
87PTK20.67239515
88PRKCH0.66897988
89PRKD20.66287902
90MAPK120.65618111
91CAMK2D0.65170502
92NTRK10.64510059
93LIMK10.63099661
94PRKD30.62347725
95FER0.61322723
96MAPK70.59557596
97STK30.59451063
98MTOR0.58258936
99ERBB40.58118209
100PDPK10.56383658
101PDK20.56148110
102MAP3K20.54568103
103FLT30.54264347
104RET0.51920013
105CDK70.50955892
106BLK0.50944881
107PRKCE0.50518202
108MAPK110.50508090
109INSR0.48912623
110TYRO30.48321186
111PAK10.48058653
112MOS0.46228634
113BRAF0.44752731
114IGF1R0.44738481
115BRSK10.43962878
116SCYL20.43809392
117FGFR30.42441571
118ABL10.42289475
119PIK3CG0.42252428
120ABL20.42135524
121LRRK20.41958922
122SRC0.41914851
123FGFR10.41347613
124EIF2AK10.40809773
125STK100.39423820
126HCK0.39297768
127NEK20.37949021
128JAK20.37026194
129MAP3K130.37002121
130CDK150.36657056
131PAK60.36563267
132PRKG20.36001369
133GRK70.35913819
134MAP2K20.35665038
135MAP2K10.35323233
136CDK11A0.35241603
137MAP3K10.34488344
138MELK0.33128824
139CDK180.31963103
140MAPKAPK20.31360019
141AKT20.30590592
142NEK10.30170027
143CDK90.29108349

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.84505993
2Fatty acid elongation_Homo sapiens_hsa000622.67597775
3Staphylococcus aureus infection_Homo sapiens_hsa051502.53149185
4ECM-receptor interaction_Homo sapiens_hsa045122.45031048
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40656590
6Complement and coagulation cascades_Homo sapiens_hsa046102.32459667
7Nitrogen metabolism_Homo sapiens_hsa009102.23987070
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15657730
9Fatty acid metabolism_Homo sapiens_hsa012122.15188140
10Fatty acid degradation_Homo sapiens_hsa000712.13334269
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.09774908
12Lysosome_Homo sapiens_hsa041422.05481214
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03812383
14Galactose metabolism_Homo sapiens_hsa000522.01939429
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97275191
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96361799
17Propanoate metabolism_Homo sapiens_hsa006401.94354427
18PPAR signaling pathway_Homo sapiens_hsa033201.90234065
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87801221
20Other glycan degradation_Homo sapiens_hsa005111.85789677
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.82824482
22Fructose and mannose metabolism_Homo sapiens_hsa000511.75699011
23Malaria_Homo sapiens_hsa051441.70467835
24N-Glycan biosynthesis_Homo sapiens_hsa005101.61574634
25Pentose phosphate pathway_Homo sapiens_hsa000301.61473838
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.61471044
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53155445
28Focal adhesion_Homo sapiens_hsa045101.50097180
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47625772
30Butanoate metabolism_Homo sapiens_hsa006501.40040174
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39024763
32Vibrio cholerae infection_Homo sapiens_hsa051101.32293758
33Arginine and proline metabolism_Homo sapiens_hsa003301.30129662
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29701324
35Dilated cardiomyopathy_Homo sapiens_hsa054141.29123354
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27620858
37Chronic myeloid leukemia_Homo sapiens_hsa052201.22409838
38Histidine metabolism_Homo sapiens_hsa003401.22029267
39Arginine biosynthesis_Homo sapiens_hsa002201.20037591
40Tryptophan metabolism_Homo sapiens_hsa003801.19737843
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19002935
42Protein digestion and absorption_Homo sapiens_hsa049741.18618430
43Peroxisome_Homo sapiens_hsa041461.16803401
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13953884
45Amoebiasis_Homo sapiens_hsa051461.11720862
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.06339728
47Sphingolipid metabolism_Homo sapiens_hsa006001.05968565
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04335448
49Caffeine metabolism_Homo sapiens_hsa002321.03995575
50MicroRNAs in cancer_Homo sapiens_hsa052060.96817407
51Sulfur metabolism_Homo sapiens_hsa009200.95448166
52beta-Alanine metabolism_Homo sapiens_hsa004100.94164464
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93770149
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93325654
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92890185
56Hippo signaling pathway_Homo sapiens_hsa043900.92378351
57Ether lipid metabolism_Homo sapiens_hsa005650.91448987
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88328542
59Thyroid cancer_Homo sapiens_hsa052160.87973799
60Basal cell carcinoma_Homo sapiens_hsa052170.87559734
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85921855
62Phagosome_Homo sapiens_hsa041450.85901999
63TGF-beta signaling pathway_Homo sapiens_hsa043500.84673962
64Pancreatic cancer_Homo sapiens_hsa052120.84105326
65Starch and sucrose metabolism_Homo sapiens_hsa005000.83980788
66Vitamin digestion and absorption_Homo sapiens_hsa049770.82051470
67Carbon metabolism_Homo sapiens_hsa012000.81395986
68Proteoglycans in cancer_Homo sapiens_hsa052050.81043363
69HIF-1 signaling pathway_Homo sapiens_hsa040660.80678867
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79762756
71Prion diseases_Homo sapiens_hsa050200.78791661
72Glioma_Homo sapiens_hsa052140.77997307
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76053877
74Pathways in cancer_Homo sapiens_hsa052000.75963349
75ABC transporters_Homo sapiens_hsa020100.75877793
76Vitamin B6 metabolism_Homo sapiens_hsa007500.75190506
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.75113953
78Bile secretion_Homo sapiens_hsa049760.74603033
79Fatty acid biosynthesis_Homo sapiens_hsa000610.74231019
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73812636
81Renal cell carcinoma_Homo sapiens_hsa052110.72446897
82Melanoma_Homo sapiens_hsa052180.72398238
83Chemical carcinogenesis_Homo sapiens_hsa052040.71826373
84Pyruvate metabolism_Homo sapiens_hsa006200.71645551
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70586003
86Tyrosine metabolism_Homo sapiens_hsa003500.69991468
87Shigellosis_Homo sapiens_hsa051310.68252474
88VEGF signaling pathway_Homo sapiens_hsa043700.67390258
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.67013012
90Thyroid hormone synthesis_Homo sapiens_hsa049180.66283696
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65930329
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.65184170
93* Lysine degradation_Homo sapiens_hsa003100.64759298
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64399575
95Sulfur relay system_Homo sapiens_hsa041220.63830440
96Renin-angiotensin system_Homo sapiens_hsa046140.62781227
97Fat digestion and absorption_Homo sapiens_hsa049750.62693117
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60651679
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60595072
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60346050
101Pertussis_Homo sapiens_hsa051330.57860693
102Melanogenesis_Homo sapiens_hsa049160.57331675
103Prostate cancer_Homo sapiens_hsa052150.57123169
104Hedgehog signaling pathway_Homo sapiens_hsa043400.56900153
105Glutathione metabolism_Homo sapiens_hsa004800.56559574
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56270084
107Retinol metabolism_Homo sapiens_hsa008300.55065075
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54159185
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53657263
110Insulin signaling pathway_Homo sapiens_hsa049100.53282259
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53152162
112Endometrial cancer_Homo sapiens_hsa052130.53070845
113Non-small cell lung cancer_Homo sapiens_hsa052230.52872114
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52782353
115AMPK signaling pathway_Homo sapiens_hsa041520.52285103
116Small cell lung cancer_Homo sapiens_hsa052220.51583237
117Arachidonic acid metabolism_Homo sapiens_hsa005900.51505743
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51264757
119Viral myocarditis_Homo sapiens_hsa054160.51106623
120Notch signaling pathway_Homo sapiens_hsa043300.51028533
121Rap1 signaling pathway_Homo sapiens_hsa040150.50741742
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.50373868
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47200891
124Adherens junction_Homo sapiens_hsa045200.47140640
125Insulin resistance_Homo sapiens_hsa049310.47123437
126Axon guidance_Homo sapiens_hsa043600.46815335
127Osteoclast differentiation_Homo sapiens_hsa043800.46308455
128Glycerolipid metabolism_Homo sapiens_hsa005610.45647579
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45615292
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.45592681
131Salmonella infection_Homo sapiens_hsa051320.45289781
132Gap junction_Homo sapiens_hsa045400.44470636
133Estrogen signaling pathway_Homo sapiens_hsa049150.43558709
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41748311
135Ovarian steroidogenesis_Homo sapiens_hsa049130.41401138
136Phenylalanine metabolism_Homo sapiens_hsa003600.40843377
137ErbB signaling pathway_Homo sapiens_hsa040120.40687628
138Biosynthesis of amino acids_Homo sapiens_hsa012300.40597156
139Rheumatoid arthritis_Homo sapiens_hsa053230.40266714
140mTOR signaling pathway_Homo sapiens_hsa041500.40220737
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40042520
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39999159
143Tight junction_Homo sapiens_hsa045300.38439309
144Linoleic acid metabolism_Homo sapiens_hsa005910.38322944
145Glucagon signaling pathway_Homo sapiens_hsa049220.37893353
146Toxoplasmosis_Homo sapiens_hsa051450.37561080
147Endocytosis_Homo sapiens_hsa041440.37524967
148p53 signaling pathway_Homo sapiens_hsa041150.36862146
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35103808
150Bladder cancer_Homo sapiens_hsa052190.34530817

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