PLOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.92287661
2chondrocyte development (GO:0002063)4.96912950
3glomerular basement membrane development (GO:0032836)4.93866256
4chondrocyte proliferation (GO:0035988)4.92446412
5polarized epithelial cell differentiation (GO:0030859)4.79970378
6peptidyl-proline hydroxylation (GO:0019511)4.78284555
7negative regulation of fibrinolysis (GO:0051918)4.50870863
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.49698246
9endodermal cell differentiation (GO:0035987)4.32419714
10regulation of plasminogen activation (GO:0010755)4.25830533
11protein heterotrimerization (GO:0070208)4.25408306
12protein hydroxylation (GO:0018126)4.23378931
13basement membrane organization (GO:0071711)4.04526576
14bone trabecula formation (GO:0060346)4.01579111
15regulation of transforming growth factor beta2 production (GO:0032909)3.98091410
16endocardial cushion development (GO:0003197)3.94199601
17Golgi transport vesicle coating (GO:0048200)3.91391359
18COPI coating of Golgi vesicle (GO:0048205)3.91391359
19retina vasculature morphogenesis in camera-type eye (GO:0061299)3.90813999
20glomerular visceral epithelial cell development (GO:0072015)3.90581828
21paraxial mesoderm development (GO:0048339)3.88007653
22establishment of apical/basal cell polarity (GO:0035089)3.87062229
23collagen metabolic process (GO:0032963)3.86489465
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.80287098
25collagen catabolic process (GO:0030574)3.79081319
26branching involved in salivary gland morphogenesis (GO:0060445)3.77425922
27regulation of fibrinolysis (GO:0051917)3.76914586
28COPII vesicle coating (GO:0048208)3.74269278
29notochord development (GO:0030903)3.66211637
30multicellular organismal macromolecule metabolic process (GO:0044259)3.64879439
31cartilage condensation (GO:0001502)3.63984339
32cell aggregation (GO:0098743)3.63984339
33hippo signaling (GO:0035329)3.60904326
34extracellular matrix disassembly (GO:0022617)3.55638785
35positive regulation of osteoblast proliferation (GO:0033690)3.52011550
36multicellular organismal catabolic process (GO:0044243)3.50019516
37glomerular epithelial cell development (GO:0072310)3.47651632
38keratan sulfate catabolic process (GO:0042340)3.46414580
39substrate adhesion-dependent cell spreading (GO:0034446)3.45895179
40multicellular organismal metabolic process (GO:0044236)3.42181219
41peptidyl-glutamic acid carboxylation (GO:0017187)3.38254119
42protein carboxylation (GO:0018214)3.38254119
43cell adhesion mediated by integrin (GO:0033627)3.36931333
44sequestering of extracellular ligand from receptor (GO:0035581)3.36530963
45regulation of SMAD protein import into nucleus (GO:0060390)3.35844237
46desmosome organization (GO:0002934)3.35651475
47mesenchymal-epithelial cell signaling (GO:0060638)3.35582884
48negative regulation of chondrocyte differentiation (GO:0032331)3.26962829
49substrate-dependent cell migration (GO:0006929)3.25227781
50establishment or maintenance of monopolar cell polarity (GO:0061339)3.25209449
51establishment of monopolar cell polarity (GO:0061162)3.25209449
52cell-substrate junction assembly (GO:0007044)3.23728256
53embryonic skeletal joint morphogenesis (GO:0060272)3.18986437
54endothelial cell morphogenesis (GO:0001886)3.18599562
55craniofacial suture morphogenesis (GO:0097094)3.15562944
56regulation of cardioblast differentiation (GO:0051890)3.14968161
57planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14967050
58positive regulation of SMAD protein import into nucleus (GO:0060391)3.13784581
59embryonic foregut morphogenesis (GO:0048617)3.13685683
60axon extension involved in axon guidance (GO:0048846)3.13157282
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.13157282
62negative regulation of cartilage development (GO:0061037)3.07756003
63metanephric mesenchyme development (GO:0072075)3.07052227
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03512810
65regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.02495125
66atrioventricular valve morphogenesis (GO:0003181)3.01759986
67hemidesmosome assembly (GO:0031581)2.99685460
68response to follicle-stimulating hormone (GO:0032354)2.99274061
69UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97914429
70regulation of heart morphogenesis (GO:2000826)2.96980990
71kidney mesenchyme development (GO:0072074)2.95052174
72negative regulation of fatty acid transport (GO:2000192)2.93318996
73wound healing, spreading of epidermal cells (GO:0035313)2.93096278
74gastrulation with mouth forming second (GO:0001702)2.92512834
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91527591
76mesenchyme development (GO:0060485)2.91138219
77regulation of cartilage development (GO:0061035)2.91106553
78renal filtration (GO:0097205)2.91050020
79positive regulation of cartilage development (GO:0061036)2.90809461
80epithelial cell-cell adhesion (GO:0090136)2.90064362
81regulation of chondrocyte differentiation (GO:0032330)2.89683177
82protein localization to cell surface (GO:0034394)2.89034860
83cell migration involved in sprouting angiogenesis (GO:0002042)2.87996335
84lung-associated mesenchyme development (GO:0060484)2.87990360
85mesodermal cell differentiation (GO:0048333)2.87894706
86dermatan sulfate biosynthetic process (GO:0030208)2.86773893
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83510836
88* extracellular matrix organization (GO:0030198)2.82946748
89* extracellular structure organization (GO:0043062)2.82408281
904-hydroxyproline metabolic process (GO:0019471)2.82406015
91positive regulation of epithelial to mesenchymal transition (GO:0010718)2.82396985
92regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.81996389
93regulation of cell fate specification (GO:0042659)2.81844198
94nucleotide-sugar biosynthetic process (GO:0009226)2.81576442
95protein retention in ER lumen (GO:0006621)2.81535713
96skin morphogenesis (GO:0043589)2.81506259
97fibrinolysis (GO:0042730)2.78624131
98cranial suture morphogenesis (GO:0060363)2.77441817
99pericardium development (GO:0060039)2.74081905
100organ formation (GO:0048645)2.74052737
101epithelial to mesenchymal transition (GO:0001837)2.72125036
102negative regulation of protein activation cascade (GO:2000258)2.71888560
103regulation of apoptotic cell clearance (GO:2000425)2.68991370
104intestinal cholesterol absorption (GO:0030299)2.68509036
105pathway-restricted SMAD protein phosphorylation (GO:0060389)2.68075930
106positive regulation of male gonad development (GO:2000020)2.66465547
107mesenchymal cell proliferation (GO:0010463)2.66302085
108positive regulation of stem cell differentiation (GO:2000738)2.65843346
109negative regulation of cell fate specification (GO:0009996)2.65567358
110very-low-density lipoprotein particle assembly (GO:0034379)2.65086689
111regulation of protein activation cascade (GO:2000257)2.65063389
112regulation of complement activation (GO:0030449)2.65010782
113positive regulation of mesenchymal cell proliferation (GO:0002053)2.64483544
114positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64279096
115organ induction (GO:0001759)2.62538291
116outer ear morphogenesis (GO:0042473)2.62344394
117cellular response to vitamin (GO:0071295)2.62231925
118atrial septum morphogenesis (GO:0060413)2.61767566
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.61659384
120anterior/posterior axis specification, embryo (GO:0008595)2.59695974
121positive regulation of chondrocyte differentiation (GO:0032332)2.58830766
122glomerular filtration (GO:0003094)2.57647277
123positive regulation of extracellular matrix organization (GO:1903055)2.57229724
124vesicle coating (GO:0006901)2.57033321
125cellular response to vitamin D (GO:0071305)2.56857872
126regulation of extracellular matrix disassembly (GO:0010715)2.56162054
127regulation of mesenchymal cell proliferation (GO:0010464)2.55497728
128regulation of hippo signaling (GO:0035330)2.55220045
129negative regulation of embryonic development (GO:0045992)2.54439773
130dermatan sulfate metabolic process (GO:0030205)2.54335000
131wound healing, spreading of cells (GO:0044319)2.53319721
132negative regulation of complement activation (GO:0045916)2.53277859
133positive regulation of hemostasis (GO:1900048)2.53267469
134positive regulation of blood coagulation (GO:0030194)2.53267469
135lymphangiogenesis (GO:0001946)2.51881608
136venous blood vessel morphogenesis (GO:0048845)2.50519502
137actin filament depolymerization (GO:0030042)2.48787936
138platelet degranulation (GO:0002576)2.48168818
139regulation of transforming growth factor beta production (GO:0071634)2.47834111
140regulation of steroid hormone biosynthetic process (GO:0090030)2.47297290
141positive regulation of endothelial cell apoptotic process (GO:2000353)2.46074042
142hypotonic response (GO:0006971)2.44993559
143negative regulation of keratinocyte proliferation (GO:0010839)2.44875181
144negative regulation of wound healing (GO:0061045)2.44179347
145regulation of osteoblast proliferation (GO:0033688)2.44147596
146apoptotic cell clearance (GO:0043277)2.44012117
147heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.43297210
148regulation of transforming growth factor beta1 production (GO:0032908)2.40404629
149positive regulation of collagen biosynthetic process (GO:0032967)2.40233546
150cell-matrix adhesion (GO:0007160)2.39877372
151lung vasculature development (GO:0060426)2.39174994
152regulation of metalloenzyme activity (GO:0048552)2.36314729
153negative regulation of anoikis (GO:2000811)2.36106439
154positive regulation of epithelial cell migration (GO:0010634)2.35053938
155cell-substrate adhesion (GO:0031589)2.32750134
156negative regulation of coagulation (GO:0050819)2.31868863
157negative regulation of hormone metabolic process (GO:0032351)2.31801814
158positive regulation of coagulation (GO:0050820)2.31201749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human6.16733810
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.21803099
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.69479635
4CLOCK_20551151_ChIP-Seq_293T_Human2.98946480
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.88780056
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86510746
7* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.83792862
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78124406
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76445399
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.71002380
11SALL4_18804426_ChIP-ChIP_XEN_Mouse2.62733152
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.42730401
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40507337
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.39773604
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30488530
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28319312
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22289650
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.16131821
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14349745
20BRD4_25478319_ChIP-Seq_HGPS_Human2.13560745
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.12792025
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10111678
23* CJUN_26792858_Chip-Seq_BT549_Human2.08353767
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07781030
25AR_21909140_ChIP-Seq_LNCAP_Human2.02729875
26* ESR1_21235772_ChIP-Seq_MCF-7_Human2.02220679
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99997200
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99637883
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98429526
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94725150
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.92253306
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.88088682
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85805415
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.81427861
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77952997
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77952997
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77952997
38E2F7_22180533_ChIP-Seq_HELA_Human1.73804809
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72329911
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.66954972
41* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66767811
42* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66767811
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63804668
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61569678
45UBF1/2_26484160_Chip-Seq_HMECs_Human1.60658410
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60295366
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59191731
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59039566
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55492095
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.54360015
51* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53206116
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.51435333
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50178901
54* TP53_20018659_ChIP-ChIP_R1E_Mouse1.45966640
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41653812
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.40529074
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39915932
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39297414
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38833662
60TP53_18474530_ChIP-ChIP_U2OS_Human1.37488568
61TP53_16413492_ChIP-PET_HCT116_Human1.37271402
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.35732736
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34341735
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.33794287
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32821026
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32253038
67AHR_22903824_ChIP-Seq_MCF-7_Human1.32116872
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.31375276
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31326744
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31257409
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31257409
72ZNF263_19887448_ChIP-Seq_K562_Human1.30511922
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30355069
74* ESR2_21235772_ChIP-Seq_MCF-7_Human1.29488057
75* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28692656
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28495971
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28415911
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26303966
79GBX2_23144817_ChIP-Seq_PC3_Human1.24493466
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24360431
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23856095
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22679232
83* TP63_23658742_ChIP-Seq_EP156T_Human1.20716674
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20633307
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19682289
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.19170908
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.19039797
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18498881
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.17856123
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17260453
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16316155
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10967878
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10722695
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10096053
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09277667
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08916408
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08157294
98* ATF3_27146783_Chip-Seq_COLON_Human1.08133069
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.07464410
100GATA4_25053715_ChIP-Seq_YYC3_Human1.07190242
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07085134
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06858413
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.05243293
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03849557
105* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02389092
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02379143
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.02194708
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.02194708
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02068684
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.01771310
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00967963
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00716973
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00096130
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99963079
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99154279
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98651106
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98643022
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.98614785
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.97359506
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97277126
121MYC_18555785_ChIP-Seq_MESCs_Mouse0.97086613
122* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97031978
123* SOX2_20726797_ChIP-Seq_SW620_Human0.96985273
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96861162
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96663772
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96589897
127TP53_22127205_ChIP-Seq_IMR90_Human0.95703642
128* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93459245
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92930014
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92253040
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92232571
132* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92202190
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91900619
134SMAD4_21799915_ChIP-Seq_A2780_Human0.91871928
135CDX2_22108803_ChIP-Seq_LS180_Human0.90971892
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90934861
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89382848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.53716608
2MP0005503_abnormal_tendon_morphology4.35764992
3MP0004272_abnormal_basement_membrane4.14095377
4MP0005623_abnormal_meninges_morphology3.48830173
5MP0005275_abnormal_skin_tensile3.41939008
6MP0003950_abnormal_plasma_membrane3.15910817
7MP0009384_cardiac_valve_regurgitation3.08759832
8MP0003705_abnormal_hypodermis_morpholog3.03906005
9MP0003279_aneurysm2.40772123
10MP0010030_abnormal_orbit_morphology2.30722116
11MP0001958_emphysema2.29009311
12MP0002282_abnormal_trachea_morphology2.25890550
13MP0009250_abnormal_appendicular_skeleto2.20703422
14MP0005508_abnormal_skeleton_morphology2.08243899
15MP0006054_spinal_hemorrhage1.89506554
16MP0004134_abnormal_chest_morphology1.88351560
17MP0000013_abnormal_adipose_tissue1.85744342
18MP0003566_abnormal_cell_adhesion1.85328815
19MP0003942_abnormal_urinary_system1.84212210
20MP0003941_abnormal_skin_development1.82442927
21MP0000537_abnormal_urethra_morphology1.74709530
22MP0005360_urolithiasis1.72125521
23MP0000163_abnormal_cartilage_morphology1.72048300
24MP0009053_abnormal_anal_canal1.71889059
25MP0000534_abnormal_ureter_morphology1.71870468
26MP0001299_abnormal_eye_distance/1.70379697
27MP0003385_abnormal_body_wall1.69489668
28MP0010352_gastrointestinal_tract_polyps1.65541488
29MP0002896_abnormal_bone_mineralization1.60300485
30MP0002115_abnormal_skeleton_extremities1.55515901
31MP0003937_abnormal_limbs/digits/tail_de1.53981696
32MP0003868_abnormal_feces_composition1.53715049
33MP0003283_abnormal_digestive_organ1.50772411
34MP0000428_abnormal_craniofacial_morphol1.48043647
35MP0005023_abnormal_wound_healing1.47787627
36MP0000762_abnormal_tongue_morphology1.43866270
37MP0002933_joint_inflammation1.43802656
38MP0003115_abnormal_respiratory_system1.43719222
39MP0003755_abnormal_palate_morphology1.42426580
40MP0002108_abnormal_muscle_morphology1.41426303
41MP0005257_abnormal_intraocular_pressure1.40423217
42MP0003091_abnormal_cell_migration1.40074704
43MP0000049_abnormal_middle_ear1.39818688
44MP0000733_abnormal_muscle_development1.36132802
45MP0002113_abnormal_skeleton_development1.36056804
46MP0005076_abnormal_cell_differentiation1.34343772
47MP0004084_abnormal_cardiac_muscle1.33845148
48MP0003935_abnormal_craniofacial_develop1.33319892
49MP0002932_abnormal_joint_morphology1.31053936
50MP0000432_abnormal_head_morphology1.30629183
51MP0000003_abnormal_adipose_tissue1.30598162
52MP0002139_abnormal_hepatobiliary_system1.27185353
53MP0003123_paternal_imprinting1.27043172
54MP0004197_abnormal_fetal_growth/weight/1.27007168
55MP0002109_abnormal_limb_morphology1.26486682
56MP0003567_abnormal_fetal_cardiomyocyte1.26314341
57MP0001542_abnormal_bone_strength1.24109728
58MP0002116_abnormal_craniofacial_bone1.19851133
59MP0010368_abnormal_lymphatic_system1.19082964
60MP0002233_abnormal_nose_morphology1.16912156
61MP0001915_intracranial_hemorrhage1.16551142
62MP0002249_abnormal_larynx_morphology1.13596675
63MP0001661_extended_life_span1.11448826
64MP0002060_abnormal_skin_morphology1.11136613
65MP0000767_abnormal_smooth_muscle1.11124130
66MP0000516_abnormal_urinary_system1.10732481
67MP0005367_renal/urinary_system_phenotyp1.10732481
68MP0002111_abnormal_tail_morphology1.10326866
69MP0005409_darkened_coat_color1.10144100
70MP0002697_abnormal_eye_size1.09488170
71MP0005390_skeleton_phenotype1.08976224
72MP0005408_hypopigmentation1.08482553
73MP0000462_abnormal_digestive_system1.07698711
74MP0005377_hearing/vestibular/ear_phenot1.07307078
75MP0003878_abnormal_ear_physiology1.07307078
76MP0003119_abnormal_digestive_system1.07252829
77MP0002084_abnormal_developmental_patter1.07051191
78MP0002089_abnormal_postnatal_growth/wei1.06264763
79MP0003195_calcinosis1.06084824
80MP0003252_abnormal_bile_duct1.04799245
81MP0002295_abnormal_pulmonary_circulatio1.04775285
82MP0005248_abnormal_Harderian_gland1.04767773
83MP0001666_abnormal_nutrient_absorption1.01701737
84MP0001293_anophthalmia1.00159668
85MP0005164_abnormal_response_to0.99140465
86MP0009697_abnormal_copulation0.96581125
87MP0010234_abnormal_vibrissa_follicle0.96332925
88MP0002168_other_aberrant_phenotype0.96050296
89MP0002114_abnormal_axial_skeleton0.91280013
90MP0001849_ear_inflammation0.90942774
91MP0006138_congestive_heart_failure0.90566481
92MP0001286_abnormal_eye_development0.90530785
93MP0004858_abnormal_nervous_system0.90170886
94MP0003122_maternal_imprinting0.89629787
95MP0005085_abnormal_gallbladder_physiolo0.88870808
96MP0000467_abnormal_esophagus_morphology0.88030158
97MP0002925_abnormal_cardiovascular_devel0.88005166
98MP0002085_abnormal_embryonic_tissue0.85298115
99MP0004233_abnormal_muscle_weight0.83812651
100MP0002086_abnormal_extraembryonic_tissu0.83607840
101MP0010678_abnormal_skin_adnexa0.81488306
102MP0005171_absent_coat_pigmentation0.81478797
103MP0001614_abnormal_blood_vessel0.80998151
104MP0002128_abnormal_blood_circulation0.80893648
105MP0000579_abnormal_nail_morphology0.80757842
106MP0002877_abnormal_melanocyte_morpholog0.80595440
107MP0001879_abnormal_lymphatic_vessel0.80591254
108MP0001175_abnormal_lung_morphology0.79053642
109MP0002938_white_spotting0.78950344
110MP0002088_abnormal_embryonic_growth/wei0.78127211
111MP0003984_embryonic_growth_retardation0.78061177
112MP0010329_abnormal_lipoprotein_level0.77510030
113MP0002092_abnormal_eye_morphology0.76757580
114MP0005193_abnormal_anterior_eye0.76169523
115MP0009780_abnormal_chondrocyte_physiolo0.75794027
116MP0003795_abnormal_bone_structure0.75629307
117MP0001697_abnormal_embryo_size0.74329135
118MP0005380_embryogenesis_phenotype0.74117869
119MP0001672_abnormal_embryogenesis/_devel0.74117869
120MP0005365_abnormal_bile_salt0.73779040
121MP0004957_abnormal_blastocyst_morpholog0.73328605
122MP0005197_abnormal_uvea_morphology0.72881919
123MP0005595_abnormal_vascular_smooth0.72444269
124MP0003121_genomic_imprinting0.71566479
125MP0001243_abnormal_dermal_layer0.68637640
126MP0003191_abnormal_cellular_cholesterol0.68295328
127MP0000538_abnormal_urinary_bladder0.67684382
128MP0010386_abnormal_urinary_bladder0.66528117
129MP0008775_abnormal_heart_ventricle0.65802774

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.24768155
2Protrusio acetabuli (HP:0003179)5.17671745
3Epiphyseal dysplasia (HP:0002656)4.96465739
4Hypoplastic ischia (HP:0003175)4.19709301
5Vitreoretinal degeneration (HP:0000655)3.94151964
6Shallow orbits (HP:0000586)3.83193738
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.75063415
8Abnormality of the ischium (HP:0003174)3.71574063
9Neonatal short-limb short stature (HP:0008921)3.69259114
10Cervical subluxation (HP:0003308)3.64813266
11Mitral stenosis (HP:0001718)3.58887380
12Irregular epiphyses (HP:0010582)3.52956552
13Deep venous thrombosis (HP:0002625)3.47762519
14Cupped ribs (HP:0000887)3.47453474
15Cardiovascular calcification (HP:0011915)3.35037790
16Ankle contracture (HP:0006466)3.20920097
17Aortic dissection (HP:0002647)3.19185034
18Metaphyseal cupping (HP:0003021)3.11450443
19Small epiphyses (HP:0010585)3.08498720
20Aortic aneurysm (HP:0004942)3.00581356
21Cerebral aneurysm (HP:0004944)2.98983215
22Abnormality of dentin (HP:0010299)2.87280536
23Osteoarthritis (HP:0002758)2.82023137
24Atrophic scars (HP:0001075)2.75414363
25Soft skin (HP:0000977)2.74887723
26Broad metatarsal (HP:0001783)2.74799152
27Bladder diverticulum (HP:0000015)2.74384698
28Delayed epiphyseal ossification (HP:0002663)2.74274757
29Flat acetabular roof (HP:0003180)2.73316121
30Exostoses (HP:0100777)2.66188682
31Bell-shaped thorax (HP:0001591)2.63925542
32Mild short stature (HP:0003502)2.63761417
33Vascular calcification (HP:0004934)2.63572696
34Abnormal delivery (HP:0001787)2.59375707
35Abnormal vertebral ossification (HP:0100569)2.58288432
36Blue sclerae (HP:0000592)2.55273625
37Flat capital femoral epiphysis (HP:0003370)2.49024602
38Mesomelia (HP:0003027)2.47591451
39Hip contracture (HP:0003273)2.45058112
40Abnormality of the common coagulation pathway (HP:0010990)2.45034238
41Genu recurvatum (HP:0002816)2.44171718
42Abnormal tarsal ossification (HP:0008369)2.43381802
43Short nail (HP:0001799)2.43333580
44Coxa vara (HP:0002812)2.42526831
45* Platyspondyly (HP:0000926)2.39076229
46Ulnar bowing (HP:0003031)2.37013852
47* Wormian bones (HP:0002645)2.35227291
48Limited hip movement (HP:0008800)2.34009640
49Vascular tortuosity (HP:0004948)2.32846054
50Menorrhagia (HP:0000132)2.28824525
51Radial bowing (HP:0002986)2.26484820
52Mitral valve prolapse (HP:0001634)2.26402600
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.26024947
54Osteolytic defects of the hand bones (HP:0009699)2.26024947
55Broad long bones (HP:0005622)2.25945308
56Abnormality of the proximal phalanges of the hand (HP:0009834)2.25103488
57Abnormality of the intrinsic pathway (HP:0010989)2.24381310
58Limited elbow extension (HP:0001377)2.23065557
59Asymmetry of the thorax (HP:0001555)2.22154516
60Absent frontal sinuses (HP:0002688)2.21815489
61Right ventricular cardiomyopathy (HP:0011663)2.21172045
62Follicular hyperkeratosis (HP:0007502)2.19366716
63Genu varum (HP:0002970)2.18889944
64Abnormality of the acetabulum (HP:0003170)2.17868681
65Abnormality of the pubic bones (HP:0003172)2.17117982
66Dilatation of the ascending aorta (HP:0005111)2.16818093
67Flattened epiphyses (HP:0003071)2.16246981
68Abnormal foot bone ossification (HP:0010675)2.15748930
69Broad phalanx (HP:0006009)2.10050001
70Biconcave vertebral bodies (HP:0004586)2.10046091
71Abnormality of carpal bone ossification (HP:0006257)2.07851990
72Spinal rigidity (HP:0003306)2.07566742
73Broad ribs (HP:0000885)2.06634664
74Ankyloglossia (HP:0010296)2.06613976
75Abnormal ossification of hand bones (HP:0005921)2.06354341
76Broad thumb (HP:0011304)2.05918996
77Vertebral clefting (HP:0008428)2.05339713
78Metaphyseal dysplasia (HP:0100255)2.04354561
79Striae distensae (HP:0001065)2.04312708
80Rhizomelia (HP:0008905)2.04061534
81Wide anterior fontanel (HP:0000260)2.03842008
82Thin ribs (HP:0000883)2.01618907
83Aortic regurgitation (HP:0001659)2.01074441
84Spinal cord compression (HP:0002176)2.00222425
85Arterial tortuosity (HP:0005116)2.00180036
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99966817
87Short 4th metacarpal (HP:0010044)1.99966817
88Prolonged partial thromboplastin time (HP:0003645)1.98726754
89Joint laxity (HP:0001388)1.98506706
90Abnormality of the 2nd finger (HP:0004100)1.94415752
91Back pain (HP:0003418)1.93490815
92Fragile skin (HP:0001030)1.90669412
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90517964
94Ovoid vertebral bodies (HP:0003300)1.89161792
95Mitral regurgitation (HP:0001653)1.88362683
96Abnormality of oral frenula (HP:0000190)1.88069688
97Peritonitis (HP:0002586)1.87549400
98Natal tooth (HP:0000695)1.87373971
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86890407
100Abnormality of femoral epiphyses (HP:0006499)1.86890407
101Spondylolisthesis (HP:0003302)1.86402195
102Synostosis of carpal bones (HP:0005048)1.86306650
103Tetraparesis (HP:0002273)1.84295150
104Broad phalanges of the hand (HP:0009768)1.84145034
105Abnormal hand bone ossification (HP:0010660)1.83606279
106Wrist flexion contracture (HP:0001239)1.81731416
107Vertebral hypoplasia (HP:0008417)1.81650147
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81650147
109Broad finger (HP:0001500)1.80874568
110Delayed closure of the anterior fontanelle (HP:0001476)1.80778647
111Coronal craniosynostosis (HP:0004440)1.80706753
112Persistence of primary teeth (HP:0006335)1.80421129
113Type 1 muscle fiber predominance (HP:0003803)1.80000318
114Flared iliac wings (HP:0002869)1.79032748
115Hyperextensible skin (HP:0000974)1.78959136
116Beaking of vertebral bodies (HP:0004568)1.78623149
117Aneurysm (HP:0002617)1.78597891
118Bowing of the arm (HP:0006488)1.78250583
119Bowed forearm bones (HP:0003956)1.78250583
120Protruding ear (HP:0000411)1.78247602
121Mixed hearing impairment (HP:0000410)1.78101667
122Short hallux (HP:0010109)1.77742451
123Hypobetalipoproteinemia (HP:0003563)1.77555572
124Vertebral compression fractures (HP:0002953)1.76914509
125Micromelia (HP:0002983)1.76788251
126Bowel diverticulosis (HP:0005222)1.76242735
127Tibial bowing (HP:0002982)1.75933858
128Overgrowth (HP:0001548)1.75014399
129Broad palm (HP:0001169)1.70489923
130Syringomyelia (HP:0003396)1.68100496
131Spinal cord lesions (HP:0100561)1.68100496
132Vertebral arch anomaly (HP:0008438)1.67418353
133Pulmonic stenosis (HP:0001642)1.66840932
134Conjugated hyperbilirubinemia (HP:0002908)1.62798780
135* Elbow flexion contracture (HP:0002987)1.62591292
136Disproportionate tall stature (HP:0001519)1.62427931
137Hypolipoproteinemia (HP:0010981)1.62258425
138Increased mean platelet volume (HP:0011877)1.62236204
139Thin skin (HP:0000963)1.61758429
140Ectopia lentis (HP:0001083)1.61742770
141* Inguinal hernia (HP:0000023)1.61410352
142Recurrent corneal erosions (HP:0000495)1.60777896
143* Pterygium (HP:0001059)1.58529977
144Hypophosphatemic rickets (HP:0004912)1.58351115
145Breech presentation (HP:0001623)1.58271036
146Abnormality of Sharpey fibers (HP:0100685)1.57590252
147Decreased skull ossification (HP:0004331)1.55799598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.40354232
2LATS13.99036115
3PDGFRA2.86872503
4PKN22.86454168
5TTN2.45794610
6EPHB22.41274351
7LATS22.34808148
8NTRK12.33164828
9TRIB32.29012609
10STK38L2.19179947
11EPHA21.99758409
12SIK11.89940993
13STK31.88984394
14FGFR11.83426224
15MET1.83352972
16EPHA31.79970109
17CDK121.65686160
18PAK41.62596005
19BMX1.61185175
20PAK21.59467670
21ERBB31.59146335
22FER1.54469173
23TRPM71.51652412
24AKT31.49856960
25PNCK1.45824936
26DMPK1.40942893
27PTK21.36023980
28STK381.31997064
29RIPK11.31766214
30EIF2AK11.31586840
31PTK61.31093025
32TGFBR11.31026934
33EIF2AK31.27886646
34PAK31.25970288
35BCR1.25334041
36LRRK21.25212566
37NUAK11.24224557
38CDK81.23532740
39MAP3K31.21097020
40BRSK21.20889591
41MTOR1.15298855
42MAP3K121.11496536
43ROCK11.10358142
44TGFBR21.09782711
45PDGFRB1.08535290
46SCYL21.01815124
47FGFR21.01787020
48MAP3K21.01220756
49CDK60.98000987
50LIMK10.97167625
51PLK20.96743869
52PBK0.96490423
53TESK10.92890638
54PLK30.90948366
55STK390.90608616
56TIE10.89548811
57RPS6KB20.88821740
58ERN10.88552424
59IRAK30.88030300
60LMTK20.85950232
61NEK90.85792531
62RPS6KA40.84519759
63TYRO30.82322524
64MKNK10.79836354
65FLT30.79297121
66EEF2K0.77195689
67PIK3CA0.76098422
68ILK0.76016279
69ROCK20.75713926
70NEK10.75576988
71ARAF0.70113709
72MOS0.67045419
73NEK20.66931533
74MST1R0.66827712
75MAP3K100.65124063
76WNK40.64066001
77PRKG20.63638478
78CDK40.62778132
79FGFR40.62341818
80PRKCE0.61994336
81CDK70.61250410
82STK100.60792318
83ZAK0.59794750
84MAP3K90.59389067
85INSR0.57730791
86FRK0.57539326
87BRD40.57505141
88CDC70.57096819
89MAPKAPK30.56421320
90GSK3A0.53955159
91MELK0.53330279
92DYRK1B0.52305097
93WEE10.50709032
94BRSK10.49259752
95MAP3K80.49251766
96WNK10.48378657
97CAMK1D0.47605843
98PTK2B0.47011913
99CHEK10.46858247
100ACVR1B0.46273185
101PASK0.46135198
102PRKD30.45460411
103AURKB0.44895840
104PAK10.44121177
105MAP3K60.43636347
106RET0.43305562
107CDK90.42844859
108MYLK0.42413582
109PRKAA20.42141974
110MAPK10.41624257
111MKNK20.40217661
112TTK0.39925379
113KSR10.38826261
114CAMK1G0.37694269
115MAP2K10.36787338
116CHUK0.35947566
117CASK0.35210402
118ERBB20.35127113
119FGFR30.34397133
120CAMK2D0.34267381
121EPHB10.34111507
122STK240.33874849
123PLK10.33446475
124CDC42BPA0.32877947
125KSR20.32470040
126PDK20.31832147
127ERBB40.31754439
128MAPK110.31281109
129CHEK20.31240839
130ICK0.30945554
131PRKD10.29724626
132ADRBK10.29468117
133SRC0.29344822
134PIK3CG0.27471887

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.27208786
2Focal adhesion_Homo sapiens_hsa045103.21424809
3Protein digestion and absorption_Homo sapiens_hsa049742.90609009
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.83955129
5Small cell lung cancer_Homo sapiens_hsa052222.80684510
6Complement and coagulation cascades_Homo sapiens_hsa046102.76430674
7Hippo signaling pathway_Homo sapiens_hsa043902.48312812
8TGF-beta signaling pathway_Homo sapiens_hsa043502.46202485
9Basal cell carcinoma_Homo sapiens_hsa052172.39491605
10Adherens junction_Homo sapiens_hsa045202.33562478
11Proteoglycans in cancer_Homo sapiens_hsa052052.28784531
12Amoebiasis_Homo sapiens_hsa051462.19027757
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07694904
14Hedgehog signaling pathway_Homo sapiens_hsa043402.05320053
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.96250972
16MicroRNAs in cancer_Homo sapiens_hsa052061.84869075
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81910167
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70499290
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.69292873
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65626926
21Sulfur metabolism_Homo sapiens_hsa009201.64921787
22Dilated cardiomyopathy_Homo sapiens_hsa054141.64453245
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.61891343
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59732123
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58177857
26Bladder cancer_Homo sapiens_hsa052191.57892187
27Wnt signaling pathway_Homo sapiens_hsa043101.46781582
28Pathways in cancer_Homo sapiens_hsa052001.44543300
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42097286
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41999349
31Tight junction_Homo sapiens_hsa045301.38084545
32p53 signaling pathway_Homo sapiens_hsa041151.35908207
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.34117295
34Melanoma_Homo sapiens_hsa052181.33544722
35Prostate cancer_Homo sapiens_hsa052151.30886132
36Starch and sucrose metabolism_Homo sapiens_hsa005001.28732497
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27425415
38Cell cycle_Homo sapiens_hsa041101.26939487
39Steroid biosynthesis_Homo sapiens_hsa001001.22385478
40Chronic myeloid leukemia_Homo sapiens_hsa052201.18355487
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15465154
42Axon guidance_Homo sapiens_hsa043601.14078612
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10224197
44Malaria_Homo sapiens_hsa051441.09928869
45HTLV-I infection_Homo sapiens_hsa051661.06535989
46Fatty acid biosynthesis_Homo sapiens_hsa000611.04593251
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04439535
48Toxoplasmosis_Homo sapiens_hsa051451.03994908
49HIF-1 signaling pathway_Homo sapiens_hsa040661.02937651
50Fructose and mannose metabolism_Homo sapiens_hsa000511.01853265
51Vitamin B6 metabolism_Homo sapiens_hsa007501.01713687
52Renal cell carcinoma_Homo sapiens_hsa052111.01495831
53Viral myocarditis_Homo sapiens_hsa054161.00713726
54Melanogenesis_Homo sapiens_hsa049160.98286194
55Protein export_Homo sapiens_hsa030600.96912177
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96765660
57RNA transport_Homo sapiens_hsa030130.96615112
58Fat digestion and absorption_Homo sapiens_hsa049750.95836704
59Colorectal cancer_Homo sapiens_hsa052100.95198442
60Rap1 signaling pathway_Homo sapiens_hsa040150.94386863
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.93098016
62Sphingolipid metabolism_Homo sapiens_hsa006000.92890470
63PPAR signaling pathway_Homo sapiens_hsa033200.91216051
64mTOR signaling pathway_Homo sapiens_hsa041500.90774185
65Pancreatic cancer_Homo sapiens_hsa052120.87354541
66Notch signaling pathway_Homo sapiens_hsa043300.85099817
67Viral carcinogenesis_Homo sapiens_hsa052030.83464018
68Biosynthesis of amino acids_Homo sapiens_hsa012300.82726928
69Arginine biosynthesis_Homo sapiens_hsa002200.81064397
70Arginine and proline metabolism_Homo sapiens_hsa003300.80043086
71Fatty acid metabolism_Homo sapiens_hsa012120.79523936
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77772332
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77205665
74N-Glycan biosynthesis_Homo sapiens_hsa005100.77057007
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76278974
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74413188
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74145440
78Endometrial cancer_Homo sapiens_hsa052130.73427418
79Selenocompound metabolism_Homo sapiens_hsa004500.71940897
80Fatty acid degradation_Homo sapiens_hsa000710.70545283
81Circadian rhythm_Homo sapiens_hsa047100.70460431
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.70413310
83Thyroid cancer_Homo sapiens_hsa052160.70130023
84Glioma_Homo sapiens_hsa052140.69894839
85One carbon pool by folate_Homo sapiens_hsa006700.69836715
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69171999
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68393139
88Bile secretion_Homo sapiens_hsa049760.67391288
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65899342
90Thyroid hormone synthesis_Homo sapiens_hsa049180.64659237
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64584542
92Ovarian steroidogenesis_Homo sapiens_hsa049130.64034898
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63255207
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62481547
95Pentose phosphate pathway_Homo sapiens_hsa000300.61611007
96Pyruvate metabolism_Homo sapiens_hsa006200.61105472
97Other glycan degradation_Homo sapiens_hsa005110.59510079
98Glucagon signaling pathway_Homo sapiens_hsa049220.56086631
99Renin-angiotensin system_Homo sapiens_hsa046140.56014312
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55606810
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55245969
102Hepatitis B_Homo sapiens_hsa051610.55184425
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54945136
104mRNA surveillance pathway_Homo sapiens_hsa030150.54744231
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53915192
106FoxO signaling pathway_Homo sapiens_hsa040680.52604984
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52574892
108Platelet activation_Homo sapiens_hsa046110.52522316
109Glycerolipid metabolism_Homo sapiens_hsa005610.52311577
110Galactose metabolism_Homo sapiens_hsa000520.51824138
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.51620432
112Vitamin digestion and absorption_Homo sapiens_hsa049770.51399482
113Shigellosis_Homo sapiens_hsa051310.51305391
114Propanoate metabolism_Homo sapiens_hsa006400.51240624
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51157842
116Phenylalanine metabolism_Homo sapiens_hsa003600.49523421
117ABC transporters_Homo sapiens_hsa020100.49190651
118Retinol metabolism_Homo sapiens_hsa008300.49178679
119* Lysine degradation_Homo sapiens_hsa003100.48215007
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47689921
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47068902
122Carbon metabolism_Homo sapiens_hsa012000.46953869
123Ras signaling pathway_Homo sapiens_hsa040140.46789914
124Gap junction_Homo sapiens_hsa045400.46754201
125TNF signaling pathway_Homo sapiens_hsa046680.45153789
126Histidine metabolism_Homo sapiens_hsa003400.44683044
127Nitrogen metabolism_Homo sapiens_hsa009100.44555538
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42281414
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41709501
130Glutathione metabolism_Homo sapiens_hsa004800.40594570
131Tyrosine metabolism_Homo sapiens_hsa003500.40048765
132Apoptosis_Homo sapiens_hsa042100.39956797
133Spliceosome_Homo sapiens_hsa030400.39558658
134Estrogen signaling pathway_Homo sapiens_hsa049150.39430070
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38269955
136AMPK signaling pathway_Homo sapiens_hsa041520.38221510
137Prion diseases_Homo sapiens_hsa050200.35655923
138Endocytosis_Homo sapiens_hsa041440.34946316
139Phagosome_Homo sapiens_hsa041450.34739527
140ErbB signaling pathway_Homo sapiens_hsa040120.34689288
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.34180854
142Insulin resistance_Homo sapiens_hsa049310.33985261
143MAPK signaling pathway_Homo sapiens_hsa040100.32021003
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30041283
145Nucleotide excision repair_Homo sapiens_hsa034200.29880055
146RNA degradation_Homo sapiens_hsa030180.28972192
147Oocyte meiosis_Homo sapiens_hsa041140.27519024
148Systemic lupus erythematosus_Homo sapiens_hsa053220.27271350
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26883860
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.25606897
151Vibrio cholerae infection_Homo sapiens_hsa051100.24746747

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