PLOD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1apoptotic cell clearance (GO:0043277)5.54788872
2endodermal cell differentiation (GO:0035987)4.50899253
3protein heterotrimerization (GO:0070208)4.40015745
4skin morphogenesis (GO:0043589)4.25402848
5cell adhesion mediated by integrin (GO:0033627)4.20116404
6* collagen fibril organization (GO:0030199)4.19729615
7regulation of integrin activation (GO:0033623)3.99239245
8hemidesmosome assembly (GO:0031581)3.94782336
9mannose metabolic process (GO:0006013)3.91275709
10wound healing, spreading of epidermal cells (GO:0035313)3.90846077
11low-density lipoprotein particle clearance (GO:0034383)3.89509476
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.87105893
13semaphorin-plexin signaling pathway (GO:0071526)3.85759025
14protein localization to endosome (GO:0036010)3.84626965
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.77131610
16peptidyl-proline hydroxylation (GO:0019511)3.75365560
17regulation of early endosome to late endosome transport (GO:2000641)3.74379071
18keratan sulfate catabolic process (GO:0042340)3.67076786
19negative regulation of fatty acid transport (GO:2000192)3.52111701
20adhesion of symbiont to host cell (GO:0044650)3.51853276
21virion attachment to host cell (GO:0019062)3.51853276
22collagen metabolic process (GO:0032963)3.50887998
23positive regulation of endothelial cell apoptotic process (GO:2000353)3.49746471
24collagen catabolic process (GO:0030574)3.45410044
25modulation by symbiont of host defense response (GO:0052031)3.44667690
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44667690
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44667690
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.44667690
29modulation by symbiont of host immune response (GO:0052553)3.44667690
30positive regulation by symbiont of host defense response (GO:0052509)3.44667690
31melanin biosynthetic process (GO:0042438)3.42569631
32protein maturation by protein folding (GO:0022417)3.39398074
33chondrocyte proliferation (GO:0035988)3.36110724
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35522097
35regulation of apoptotic cell clearance (GO:2000425)3.31238915
36wound healing, spreading of cells (GO:0044319)3.30871511
37multicellular organismal macromolecule metabolic process (GO:0044259)3.27665854
38COPI coating of Golgi vesicle (GO:0048205)3.27131470
39Golgi transport vesicle coating (GO:0048200)3.27131470
40extracellular matrix disassembly (GO:0022617)3.21669739
41response to laminar fluid shear stress (GO:0034616)3.21402106
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.21155850
43regulation of plasminogen activation (GO:0010755)3.20656438
44adherens junction assembly (GO:0034333)3.17917558
45glucose 6-phosphate metabolic process (GO:0051156)3.16663283
46glial cell migration (GO:0008347)3.16459947
47multicellular organismal catabolic process (GO:0044243)3.14597554
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.12750812
49protein hydroxylation (GO:0018126)3.12488430
50regulation of extracellular matrix disassembly (GO:0010715)3.10456636
51detection of molecule of bacterial origin (GO:0032490)3.08239744
52negative regulation of cell junction assembly (GO:1901889)3.07228676
53negative regulation of adherens junction organization (GO:1903392)3.07228676
54negative regulation of focal adhesion assembly (GO:0051895)3.07228676
55multicellular organismal metabolic process (GO:0044236)3.06795589
56hyaluronan catabolic process (GO:0030214)3.06429158
57cell-substrate adherens junction assembly (GO:0007045)3.04684674
58focal adhesion assembly (GO:0048041)3.04684674
59proline biosynthetic process (GO:0006561)3.04525687
60negative regulation of smooth muscle cell migration (GO:0014912)3.03528100
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02600762
62positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01963831
63regulation of macrophage chemotaxis (GO:0010758)2.96984062
64vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96676186
65membrane protein ectodomain proteolysis (GO:0006509)2.95124839
66endoplasmic reticulum unfolded protein response (GO:0030968)2.93670361
67regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92834100
68cortical actin cytoskeleton organization (GO:0030866)2.91812613
69peptidyl-glutamic acid carboxylation (GO:0017187)2.91559353
70protein carboxylation (GO:0018214)2.91559353
71melanin metabolic process (GO:0006582)2.91414167
72negative regulation of granulocyte differentiation (GO:0030853)2.90574545
73* basement membrane organization (GO:0071711)2.88884377
74planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88328649
75cellular response to vitamin (GO:0071295)2.88205113
76negative regulation of cell size (GO:0045792)2.86836580
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86644778
78regulation of cholesterol storage (GO:0010885)2.84570897
79protein retention in ER lumen (GO:0006621)2.83209775
80response to fluid shear stress (GO:0034405)2.81859102
81sequestering of extracellular ligand from receptor (GO:0035581)2.81070483
82substrate adhesion-dependent cell spreading (GO:0034446)2.80920789
83endothelial cell chemotaxis (GO:0035767)2.79878962
84regulation of mononuclear cell migration (GO:0071675)2.79228099
85positive regulation of cell adhesion mediated by integrin (GO:0033630)2.78282970
86positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.77067403
87bone trabecula formation (GO:0060346)2.76149560
88regulation of macrophage cytokine production (GO:0010935)2.75770315
89ER-nucleus signaling pathway (GO:0006984)2.73909221
90UV protection (GO:0009650)2.73423551
91negative regulation of chondrocyte differentiation (GO:0032331)2.73083060
92macrophage activation involved in immune response (GO:0002281)2.72194989
93cellular response to unfolded protein (GO:0034620)2.72133720
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.71974638
95axon extension involved in axon guidance (GO:0048846)2.71974638
96epithelial cell-cell adhesion (GO:0090136)2.71278029
97embryo implantation (GO:0007566)2.69718125
98regulation of interferon-beta biosynthetic process (GO:0045357)2.69525688
99positive regulation of extracellular matrix organization (GO:1903055)2.69483713
100type B pancreatic cell proliferation (GO:0044342)2.69160788
101stress fiber assembly (GO:0043149)2.68860764
102cellular response to interferon-alpha (GO:0035457)2.68441909
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68253703
104vascular endothelial growth factor signaling pathway (GO:0038084)2.67294562
105regulation of nuclease activity (GO:0032069)2.65245193
106neutrophil activation involved in immune response (GO:0002283)2.64868188
107positive regulation of receptor recycling (GO:0001921)2.64507935
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.63064424
109negative regulation of phagocytosis (GO:0050765)2.61641643
110desmosome organization (GO:0002934)2.60894455
111vesicle coating (GO:0006901)2.59580005
112endocytic recycling (GO:0032456)2.58363538
113activation of Rac GTPase activity (GO:0032863)2.57205562
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57002062
115regulation of SMAD protein import into nucleus (GO:0060390)2.56719149
116cell migration involved in heart development (GO:0060973)2.56538640
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.56528658
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.56306797
119chondroitin sulfate biosynthetic process (GO:0030206)2.55853224
120integrin-mediated signaling pathway (GO:0007229)2.55847822
121positive regulation of p38MAPK cascade (GO:1900745)2.55170369
122hyaluronan metabolic process (GO:0030212)2.54991863
123chondroitin sulfate catabolic process (GO:0030207)2.53975129
124negative regulation of interleukin-12 production (GO:0032695)2.52959316
125cellular response to topologically incorrect protein (GO:0035967)2.52178463
126regulation of apoptotic process involved in morphogenesis (GO:1902337)2.51742738
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50371680
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50048728
129cell-substrate junction assembly (GO:0007044)2.49809190
130glucose catabolic process (GO:0006007)2.48843483
131cortical cytoskeleton organization (GO:0030865)2.48683270
132dermatan sulfate biosynthetic process (GO:0030208)2.48327353
133pentose-phosphate shunt (GO:0006098)2.48101695
134positive regulation of astrocyte differentiation (GO:0048711)2.48024285
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.47648983
136actin filament depolymerization (GO:0030042)2.47504865
137platelet degranulation (GO:0002576)2.46813462
138positive regulation of osteoblast proliferation (GO:0033690)2.45837547
139apoptotic process involved in morphogenesis (GO:0060561)2.43541562
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42986584
141pinocytosis (GO:0006907)2.42918066
1424-hydroxyproline metabolic process (GO:0019471)2.42553386
143response to peptidoglycan (GO:0032494)2.42349140
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42307282
145positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.42049409
146cellular response to vitamin D (GO:0071305)2.41102048
147positive regulation of nuclease activity (GO:0032075)2.40756926
148mesenchymal-epithelial cell signaling (GO:0060638)2.40592895
149negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40393645
150barbed-end actin filament capping (GO:0051016)2.38773789
151substrate-dependent cell migration (GO:0006929)2.36399253
152* extracellular matrix organization (GO:0030198)2.36021515
153adhesion of symbiont to host (GO:0044406)2.35993260
154branching involved in salivary gland morphogenesis (GO:0060445)2.35950657
155* extracellular structure organization (GO:0043062)2.34837047
156NADPH regeneration (GO:0006740)2.34640698
157positive regulation of interferon-alpha production (GO:0032727)2.34638620
158platelet aggregation (GO:0070527)2.33596612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.07713003
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.98896308
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.90688634
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58479952
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39693492
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.81475423
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.81474738
8CLOCK_20551151_ChIP-Seq_293T_Human2.73124714
9ZNF263_19887448_ChIP-Seq_K562_Human2.72314112
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68943196
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.58921790
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.54687813
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.53824115
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.53800854
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.19950596
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19288951
17VDR_21846776_ChIP-Seq_THP-1_Human2.18480844
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07335717
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05582187
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.05272111
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00342334
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00116708
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91833592
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91789242
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.88999505
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87422700
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86829937
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86419999
29LXR_22292898_ChIP-Seq_THP-1_Human1.78549944
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78366764
31VDR_24763502_ChIP-Seq_THP-1_Human1.74754518
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71722465
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70755446
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69639252
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67714329
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60350420
37RACK7_27058665_Chip-Seq_MCF-7_Human1.59670053
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59055970
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58425119
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57327509
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57100816
42KDM2B_26808549_Chip-Seq_K562_Human1.55789943
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53334895
44MYC_22102868_ChIP-Seq_BL_Human1.53154134
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52957154
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52155087
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51617844
48ATF3_27146783_Chip-Seq_COLON_Human1.50174184
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47691043
50KDM2B_26808549_Chip-Seq_DND41_Human1.47427340
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.47260891
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43290760
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43206569
54TP53_22127205_ChIP-Seq_IMR90_Human1.40264201
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.38937359
56TCF7_22412390_ChIP-Seq_EML_Mouse1.36382958
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32535378
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32431663
59SPI1_23127762_ChIP-Seq_K562_Human1.30841162
60CJUN_26792858_Chip-Seq_BT549_Human1.30585193
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29312069
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28435915
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28339913
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27872954
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27828461
66BRD4_25478319_ChIP-Seq_HGPS_Human1.27281287
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.27257452
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26854698
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25699583
70MAF_26560356_Chip-Seq_TH1_Human1.25057025
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24827082
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24827082
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24353176
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.24312992
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22404975
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.22123772
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21420856
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19242943
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19118265
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18539749
81TFEB_21752829_ChIP-Seq_HELA_Human1.17486015
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.17058466
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16806086
84P68_20966046_ChIP-Seq_HELA_Human1.14710635
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14516935
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.14373360
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12856576
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12255464
89SPI1_23547873_ChIP-Seq_NB4_Human1.12069237
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12017908
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11341098
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.10889229
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10396423
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.09981932
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.09779250
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09626908
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09592294
98SMC4_20622854_ChIP-Seq_HELA_Human1.09390974
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07692550
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07503732
101NCOR1_26117541_ChIP-Seq_K562_Human1.07447432
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07410847
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07041953
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06658849
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06208346
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05650607
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05528600
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04710359
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04277755
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03575330
111UTX_26944678_Chip-Seq_JUKART_Human1.02837957
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01788335
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01703089
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01699134
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01203202
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00913339
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00651835
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00017229
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.00013911
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98970182
121SOX2_20726797_ChIP-Seq_SW620_Human0.98813756
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98667069
123SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98488236
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.98081787
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97870616
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97278785
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.97179399
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97121797
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96772431
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96600124
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96327056
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96124252
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95896832
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.95430786
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.95430786
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94947833
137* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93685474
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.93667005
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93506611
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93353025
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92724461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen6.49813326
2MP0003705_abnormal_hypodermis_morpholog4.40971003
3MP0005171_absent_coat_pigmentation3.91745890
4MP0005275_abnormal_skin_tensile3.66240992
5MP0005503_abnormal_tendon_morphology3.21711206
6MP0003279_aneurysm3.18396569
7MP0001958_emphysema2.73750026
8MP0003566_abnormal_cell_adhesion2.66490866
9MP0005058_abnormal_lysosome_morphology2.46409036
10MP0006054_spinal_hemorrhage2.39716659
11MP0005451_abnormal_body_composition2.27943694
12* MP0004272_abnormal_basement_membrane2.24836979
13MP0005408_hypopigmentation2.17407803
14MP0003303_peritoneal_inflammation2.04899702
15MP0005023_abnormal_wound_healing2.03043598
16MP0010352_gastrointestinal_tract_polyps1.99900466
17MP0005623_abnormal_meninges_morphology1.98695750
18MP0001533_abnormal_skeleton_physiology1.83959512
19MP0005257_abnormal_intraocular_pressure1.81614911
20MP0003091_abnormal_cell_migration1.81234797
21MP0003436_decreased_susceptibility_to1.80147767
22MP0005409_darkened_coat_color1.74531335
23MP0009840_abnormal_foam_cell1.72586014
24MP0009384_cardiac_valve_regurgitation1.70341081
25MP0005076_abnormal_cell_differentiation1.60024285
26MP0003300_gastrointestinal_ulcer1.55776686
27MP0008260_abnormal_autophagy1.55567066
28MP0005508_abnormal_skeleton_morphology1.55290294
29MP0005390_skeleton_phenotype1.52715859
30MP0000343_altered_response_to1.52355989
31MP0005360_urolithiasis1.51474849
32MP0003172_abnormal_lysosome_physiology1.50812563
33MP0002089_abnormal_postnatal_growth/wei1.50095799
34MP0000767_abnormal_smooth_muscle1.48528505
35MP0002933_joint_inflammation1.46981568
36MP0003724_increased_susceptibility_to1.45545164
37MP0009278_abnormal_bone_marrow1.44596633
38MP0004233_abnormal_muscle_weight1.43238541
39MP0000751_myopathy1.40804334
40MP0000733_abnormal_muscle_development1.40158803
41MP0003448_altered_tumor_morphology1.34708956
42* MP0002060_abnormal_skin_morphology1.34204888
43MP0002998_abnormal_bone_remodeling1.31741367
44MP0002295_abnormal_pulmonary_circulatio1.31396143
45MP0002419_abnormal_innate_immunity1.30440884
46MP0003453_abnormal_keratinocyte_physiol1.30223791
47MP0001348_abnormal_lacrimal_gland1.28055799
48MP0003191_abnormal_cellular_cholesterol1.25726757
49MP0002877_abnormal_melanocyte_morpholog1.25005638
50MP0003950_abnormal_plasma_membrane1.23812205
51MP0000858_altered_metastatic_potential1.21115469
52MP0004185_abnormal_adipocyte_glucose1.19776130
53MP0010234_abnormal_vibrissa_follicle1.19432700
54MP0001542_abnormal_bone_strength1.18362353
55MP0004381_abnormal_hair_follicle1.17945717
56MP0001243_abnormal_dermal_layer1.17654071
57MP0000371_diluted_coat_color1.16281932
58MP0003329_amyloid_beta_deposits1.13897682
59MP0006082_CNS_inflammation1.11671465
60MP0010030_abnormal_orbit_morphology1.10148522
61MP0005164_abnormal_response_to1.09313246
62MP0002896_abnormal_bone_mineralization1.09231712
63MP0002075_abnormal_coat/hair_pigmentati1.05101678
64MP0003075_altered_response_to1.04149890
65MP0000015_abnormal_ear_pigmentation1.03271910
66MP0003045_fibrosis1.02428739
67MP0009053_abnormal_anal_canal1.01163178
68* MP0001915_intracranial_hemorrhage1.00962534
69MP0010307_abnormal_tumor_latency1.00746464
70MP0000750_abnormal_muscle_regeneration0.99114904
71MP0010368_abnormal_lymphatic_system0.98688853
72MP0004858_abnormal_nervous_system0.97164975
73MP0002282_abnormal_trachea_morphology0.97110330
74MP0001186_pigmentation_phenotype0.96905506
75MP0005670_abnormal_white_adipose0.95917636
76* MP0001614_abnormal_blood_vessel0.94856158
77MP0000534_abnormal_ureter_morphology0.93988610
78MP0000249_abnormal_blood_vessel0.93463735
79MP0003795_abnormal_bone_structure0.93443402
80MP0002168_other_aberrant_phenotype0.90496844
81MP0005375_adipose_tissue_phenotype0.89017655
82MP0003634_abnormal_glial_cell0.88163935
83MP0003828_pulmonary_edema0.88131753
84MP0001851_eye_inflammation0.88113743
85MP0000678_abnormal_parathyroid_gland0.87926025
86MP0002113_abnormal_skeleton_development0.87667830
87MP0000467_abnormal_esophagus_morphology0.86352352
88MP0002148_abnormal_hypersensitivity_rea0.85040199
89MP0009333_abnormal_splenocyte_physiolog0.84672761
90MP0002128_abnormal_blood_circulation0.84521645
91MP0002115_abnormal_skeleton_extremities0.84134406
92MP0002108_abnormal_muscle_morphology0.83869809
93MP0004947_skin_inflammation0.83738026
94MP0000762_abnormal_tongue_morphology0.83658269
95MP0009780_abnormal_chondrocyte_physiolo0.83459147
96MP0000003_abnormal_adipose_tissue0.82951449
97MP0001849_ear_inflammation0.82942019
98MP0001299_abnormal_eye_distance/0.82333507
99MP0005464_abnormal_platelet_physiology0.82333149
100MP0000604_amyloidosis0.82115768
101MP0005501_abnormal_skin_physiology0.80650695
102MP0000685_abnormal_immune_system0.80048838
103MP0003385_abnormal_body_wall0.79974803
104MP0005025_abnormal_response_to0.79523992
105MP0000013_abnormal_adipose_tissue0.79005626
106MP0000163_abnormal_cartilage_morphology0.78977918
107MP0005000_abnormal_immune_tolerance0.78823139
108MP0005621_abnormal_cell_physiology0.78320771
109MP0005666_abnormal_adipose_tissue0.78284712
110MP0000428_abnormal_craniofacial_morphol0.76715968
111MP0002405_respiratory_system_inflammati0.76215627
112MP0005165_increased_susceptibility_to0.74593598
113MP0000747_muscle_weakness0.74054849
114MP0003115_abnormal_respiratory_system0.73770580
115MP0004808_abnormal_hematopoietic_stem0.73596456
116* MP0001175_abnormal_lung_morphology0.72997021
117MP0000759_abnormal_skeletal_muscle0.72892474
118MP0005197_abnormal_uvea_morphology0.72779322
119MP0004883_abnormal_blood_vessel0.70426747
120MP0001835_abnormal_antigen_presentation0.70389347
121MP0006138_congestive_heart_failure0.70288851
122MP0001879_abnormal_lymphatic_vessel0.70061660
123MP0004510_myositis0.69879089
124* MP0005595_abnormal_vascular_smooth0.69151206
125MP0002925_abnormal_cardiovascular_devel0.68949868
126MP0000537_abnormal_urethra_morphology0.68797806
127MP0002796_impaired_skin_barrier0.68516734
128MP0001790_abnormal_immune_system0.68179357
129MP0005387_immune_system_phenotype0.68179357
130MP0002452_abnormal_antigen_presenting0.68129684
131MP0000465_gastrointestinal_hemorrhage0.67448651
132MP0005397_hematopoietic_system_phenotyp0.66208544
133MP0001545_abnormal_hematopoietic_system0.66208544
134MP0009785_altered_susceptibility_to0.65994262
135MP0005193_abnormal_anterior_eye0.65413356
136MP0003942_abnormal_urinary_system0.65293061
137MP0000462_abnormal_digestive_system0.64295259
138MP0005330_cardiomyopathy0.64107124
139MP0009250_abnormal_appendicular_skeleto0.61427596
140MP0002249_abnormal_larynx_morphology0.60727435
141MP0000372_irregular_coat_pigmentation0.60586072
142MP0001661_extended_life_span0.58637512
143* MP0001216_abnormal_epidermal_layer0.57825151
144MP0000920_abnormal_myelination0.57155399

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.89977297
2Protrusio acetabuli (HP:0003179)6.75493140
3Peritonitis (HP:0002586)4.98202540
4Cervical subluxation (HP:0003308)4.38526592
5Aortic dissection (HP:0002647)4.13452059
6* Shallow orbits (HP:0000586)3.87942838
7Ankle contracture (HP:0006466)3.83823990
8Vertebral compression fractures (HP:0002953)3.72826773
9* Cerebral aneurysm (HP:0004944)3.62333360
10Soft skin (HP:0000977)3.60245410
11Atrophic scars (HP:0001075)3.52330867
12Bladder diverticulum (HP:0000015)3.45771819
13Aortic aneurysm (HP:0004942)3.36092640
14Broad metatarsal (HP:0001783)3.34737286
15Systemic lupus erythematosus (HP:0002725)3.33236416
16Hyperacusis (HP:0010780)3.30792522
17Dilatation of the ascending aorta (HP:0005111)3.27783390
18Genu recurvatum (HP:0002816)3.14735244
19Achilles tendon contracture (HP:0001771)3.08053286
20Blue sclerae (HP:0000592)2.97837781
21Fragile skin (HP:0001030)2.96700554
22Wrist flexion contracture (HP:0001239)2.93011637
23Wormian bones (HP:0002645)2.92471774
24Mitral valve prolapse (HP:0001634)2.88770742
25Dysostosis multiplex (HP:0000943)2.87301878
26Abnormality of the Achilles tendon (HP:0005109)2.84301022
27Biconcave vertebral bodies (HP:0004586)2.82653183
28Osteolytic defects of the hand bones (HP:0009699)2.81692476
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.81692476
30Abnormality of dentin (HP:0010299)2.81197429
31Vascular tortuosity (HP:0004948)2.71934429
32Abnormality of the acetabulum (HP:0003170)2.63716405
33Spondylolisthesis (HP:0003302)2.62256678
34Joint stiffness (HP:0001387)2.61698042
35Increased cerebral lipofuscin (HP:0011813)2.60184026
36Spinal rigidity (HP:0003306)2.57583311
37Distal lower limb amyotrophy (HP:0008944)2.56849557
38Distal lower limb muscle weakness (HP:0009053)2.55474534
39Arterial tortuosity (HP:0005116)2.50815490
40Urinary glycosaminoglycan excretion (HP:0003541)2.50715570
41Mucopolysacchariduria (HP:0008155)2.50715570
42Abnormality of the peritoneum (HP:0002585)2.48210304
43Insomnia (HP:0100785)2.46691838
44Bowel diverticulosis (HP:0005222)2.46309406
45Increased connective tissue (HP:0009025)2.43477410
46Ulnar bowing (HP:0003031)2.43363755
47Nuclear cataract (HP:0100018)2.42652855
48Vacuolated lymphocytes (HP:0001922)2.40039853
49Eczematoid dermatitis (HP:0000976)2.38150557
50Nonimmune hydrops fetalis (HP:0001790)2.37948729
51Beaking of vertebral bodies (HP:0004568)2.37884055
52Short nail (HP:0001799)2.37699602
53Neonatal short-limb short stature (HP:0008921)2.34980015
54Natal tooth (HP:0000695)2.33684501
55Coxa vara (HP:0002812)2.33518654
56Slender build (HP:0001533)2.33053859
57Follicular hyperkeratosis (HP:0007502)2.31530765
58Type 1 muscle fiber predominance (HP:0003803)2.29454721
59Abnormality of polysaccharide metabolism (HP:0011012)2.28264923
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28264923
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28264923
62* Distal upper limb amyotrophy (HP:0007149)2.27201758
63* Upper limb amyotrophy (HP:0009129)2.27201758
64Abnormality of the distal phalanges of the toes (HP:0010182)2.22822539
65Hyperextensible skin (HP:0000974)2.22696549
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.22062101
67Renal duplication (HP:0000075)2.20140006
68Long toe (HP:0010511)2.19823607
69Disproportionate tall stature (HP:0001519)2.19402163
70* Aneurysm (HP:0002617)2.18043904
71Radial bowing (HP:0002986)2.17688771
72Deep venous thrombosis (HP:0002625)2.15175721
73Recurrent abscess formation (HP:0002722)2.14231243
74Stridor (HP:0010307)2.14037853
75Ovoid vertebral bodies (HP:0003300)2.11859599
76White forelock (HP:0002211)2.10493451
77Ectopia lentis (HP:0001083)2.09165881
78Thin bony cortex (HP:0002753)2.08943250
79Camptodactyly of toe (HP:0001836)2.08830316
80Abnormality of the odontoid process (HP:0003310)2.04689039
81Trismus (HP:0000211)2.04504021
82Deviation of the hallux (HP:0010051)2.04002398
83Bowed forearm bones (HP:0003956)2.02662911
84Bowing of the arm (HP:0006488)2.02662911
85Joint laxity (HP:0001388)2.02522187
86Abnormality of complement system (HP:0005339)2.02183111
87Mitral stenosis (HP:0001718)2.02036166
88Abnormality of liposaccharide metabolism (HP:0010968)2.00531916
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.00531916
90Abnormality of glycolipid metabolism (HP:0010969)2.00531916
91Abnormal delivery (HP:0001787)1.97771379
92Abnormal gallbladder physiology (HP:0012438)1.97524088
93Cholecystitis (HP:0001082)1.97524088
94Hypoplasia of the odontoid process (HP:0003311)1.97496311
95Premature skin wrinkling (HP:0100678)1.96418758
96Hallux valgus (HP:0001822)1.95233221
97Glomerulonephritis (HP:0000099)1.94983306
98Abnormality of the lumbar spine (HP:0100712)1.94539754
99Back pain (HP:0003418)1.94135324
100Femoral bowing (HP:0002980)1.94124807
101Flat acetabular roof (HP:0003180)1.92874191
102Axonal loss (HP:0003447)1.92783598
103Recurrent gram-negative bacterial infections (HP:0005420)1.92264361
104* Platyspondyly (HP:0000926)1.91498501
105Increased density of long bones (HP:0006392)1.91337419
106Tibial bowing (HP:0002982)1.90416842
107* Elbow flexion contracture (HP:0002987)1.89874531
108Mitral regurgitation (HP:0001653)1.87867806
109Hypoplasia of the iris (HP:0007676)1.85256460
110Hypoventilation (HP:0002791)1.84853406
111Asymmetric septal hypertrophy (HP:0001670)1.83612480
112Upper limb muscle weakness (HP:0003484)1.83373451
113Abnormality of skeletal muscle fiber size (HP:0012084)1.81656432
114Osteoarthritis (HP:0002758)1.81654400
115Broad face (HP:0000283)1.81599407
116Generalized amyotrophy (HP:0003700)1.80994511
117Hematochezia (HP:0002573)1.80682582
118Hemorrhage of the eye (HP:0011885)1.80593920
119Flat cornea (HP:0007720)1.79728631
120Increased variability in muscle fiber diameter (HP:0003557)1.78991637
121Elfin facies (HP:0004428)1.78044704
122Abnormality of carpal bone ossification (HP:0006257)1.77180355
123Nephritis (HP:0000123)1.76579578
124Patchy hypopigmentation of hair (HP:0011365)1.75874701
125Abnormality of the calcaneus (HP:0008364)1.75798685
126Recurrent bacterial skin infections (HP:0005406)1.75521390
127Mildly elevated creatine phosphokinase (HP:0008180)1.75493680
128Loss of speech (HP:0002371)1.75327904
129Spinal cord compression (HP:0002176)1.73556799
130Lower limb amyotrophy (HP:0007210)1.72411516
131Aortic regurgitation (HP:0001659)1.72313114
132Overriding aorta (HP:0002623)1.71054003
133Neurofibrillary tangles (HP:0002185)1.71023600
134Myocardial infarction (HP:0001658)1.70052215
135Scapular winging (HP:0003691)1.69216631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.93792777
2ERN14.78826069
3PKN23.75905719
4IRAK33.42990209
5TTN3.32901345
6LMTK22.94091545
7DDR22.67403316
8SMG12.40949613
9TGFBR22.20133367
10PDGFRA2.16083273
11EPHB12.08422011
12PAK42.01227094
13RIPK11.98036935
14BMX1.97482043
15PTK61.80240210
16SIK11.79667904
17CAMK1D1.79143792
18BLK1.73013199
19EPHB21.70702990
20PRPF4B1.69611570
21LRRK21.65249683
22EEF2K1.59808295
23PIM21.58487875
24MET1.51367855
25PAK21.46943818
26TBK11.46402738
27TAOK21.38991452
28MST1R1.36802042
29PTK21.31659423
30TESK11.30601580
31PRKD21.29146572
32CDK121.29139195
33RPS6KA41.29013064
34STK101.26857677
35TYK21.23362612
36MAP2K31.23268003
37NEK91.22770007
38KIT1.21578872
39FLT31.21266764
40PRKD31.20402742
41MAP3K101.18971610
42EPHA21.18210570
43TRPM71.18117491
44LATS21.17975707
45CAMK1G1.17463295
46ERBB41.14691944
47ARAF1.14480446
48CDC42BPA1.12122768
49MAP3K31.08355155
50LIMK11.06630958
51CSK1.06142564
52MYLK1.02054720
53TESK20.99366487
54CSF1R0.92650029
55ILK0.91045674
56EPHA30.90674656
57SCYL20.90648154
58MOS0.89589146
59JAK10.87328901
60ABL20.86868916
61CAMKK10.85536068
62TGFBR10.83281768
63LATS10.81574287
64MTOR0.81521978
65HCK0.80526787
66NME20.79897052
67PDGFRB0.79294325
68ICK0.77199849
69PTK2B0.77118703
70KDR0.77092441
71MAP3K110.76413138
72PDPK10.73737187
73IRAK40.73446143
74DMPK0.72604823
75MAP4K10.72301449
76PASK0.72214150
77FGFR40.71126146
78STK30.71018526
79CDK70.69612472
80ZAP700.68222899
81TYRO30.66662584
82KSR20.64842393
83DAPK30.63890746
84BRAF0.63884745
85MAPK110.63670405
86JAK30.62274906
87CDK60.61620126
88FER0.61313173
89MAP3K80.60054025
90PAK10.59704214
91MATK0.58823590
92MAP3K60.58658814
93FGFR10.57919048
94RPS6KB20.57544688
95STK380.57356696
96SIK30.56124762
97CDK80.55300042
98RPS6KL10.52111562
99RPS6KC10.52111562
100DYRK1B0.51966765
101RPS6KA60.51827267
102CAMKK20.48573628
103MAPKAPK20.48087049
104PIK3CG0.47908773
105MAP2K20.47618908
106RPS6KA20.47372781
107FGR0.47212614
108RET0.46367553
109GSK3A0.46360531
110NTRK10.45371096
111IRAK20.45248906
112MAP3K10.44657593
113IKBKB0.44215244
114ROCK20.43158436
115PRKD10.43114586
116MAP3K130.42312945
117MAP2K10.41799149
118INSR0.41705117
119ABL10.41324665
120BTK0.40127110
121BRSK10.39406750
122CLK10.39324968
123ROCK10.38884099
124ALK0.38196351
125PRKG20.38017248
126EGFR0.37826231
127MAPKAPK30.37695908
128PAK60.36899897
129SRC0.36528550
130PAK30.36384073
131CDK11A0.36051326
132CDK150.35864717
133CAMK2G0.35013052
134MAP3K20.34710168
135MARK20.34264474
136TAOK10.32733901
137CDK180.32232746
138VRK20.30077504
139AKT20.27189506
140CAMK2D0.26422187

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.12290568
2Other glycan degradation_Homo sapiens_hsa005112.94046535
3ECM-receptor interaction_Homo sapiens_hsa045122.85782174
4Staphylococcus aureus infection_Homo sapiens_hsa051502.79723115
5Malaria_Homo sapiens_hsa051442.54955669
6Lysosome_Homo sapiens_hsa041422.49530384
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.43081385
8Leishmaniasis_Homo sapiens_hsa051402.21563458
9Focal adhesion_Homo sapiens_hsa045102.16122566
10Amoebiasis_Homo sapiens_hsa051462.10529045
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05503028
12Pertussis_Homo sapiens_hsa051331.96416253
13Fructose and mannose metabolism_Homo sapiens_hsa000511.85548900
14Vibrio cholerae infection_Homo sapiens_hsa051101.85354483
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.85095315
16Pentose phosphate pathway_Homo sapiens_hsa000301.84487625
17Proteoglycans in cancer_Homo sapiens_hsa052051.79703079
18Phagosome_Homo sapiens_hsa041451.71594466
19Small cell lung cancer_Homo sapiens_hsa052221.65977326
20Legionellosis_Homo sapiens_hsa051341.62981332
21Bladder cancer_Homo sapiens_hsa052191.59257816
22Osteoclast differentiation_Homo sapiens_hsa043801.55173675
23Shigellosis_Homo sapiens_hsa051311.54727697
24Toxoplasmosis_Homo sapiens_hsa051451.50887177
25Chronic myeloid leukemia_Homo sapiens_hsa052201.50624096
26Biosynthesis of amino acids_Homo sapiens_hsa012301.49454597
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.49307172
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.49170845
29Complement and coagulation cascades_Homo sapiens_hsa046101.44166313
30Tuberculosis_Homo sapiens_hsa051521.38539996
31Sulfur relay system_Homo sapiens_hsa041221.37419183
32Salmonella infection_Homo sapiens_hsa051321.34922108
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31380143
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31309753
35Adherens junction_Homo sapiens_hsa045201.28110012
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26460694
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24276710
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22038365
39Viral myocarditis_Homo sapiens_hsa054161.21902646
40TNF signaling pathway_Homo sapiens_hsa046681.21505604
41Apoptosis_Homo sapiens_hsa042101.20516247
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20485274
43Protein digestion and absorption_Homo sapiens_hsa049741.18496623
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12679497
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11865915
46Pancreatic cancer_Homo sapiens_hsa052121.11137132
47MicroRNAs in cancer_Homo sapiens_hsa052061.11084147
48Prion diseases_Homo sapiens_hsa050201.10485154
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06494035
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04378556
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99423348
52TGF-beta signaling pathway_Homo sapiens_hsa043500.98828209
53Platelet activation_Homo sapiens_hsa046110.98534383
54N-Glycan biosynthesis_Homo sapiens_hsa005100.96855520
55Carbon metabolism_Homo sapiens_hsa012000.93560318
56Antigen processing and presentation_Homo sapiens_hsa046120.91657406
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.91445315
58* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89532009
59Notch signaling pathway_Homo sapiens_hsa043300.88947961
60Non-small cell lung cancer_Homo sapiens_hsa052230.88824063
61Caffeine metabolism_Homo sapiens_hsa002320.88367876
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87581074
63Hepatitis B_Homo sapiens_hsa051610.87461824
64HIF-1 signaling pathway_Homo sapiens_hsa040660.87419605
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85617380
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83919782
67Sphingolipid metabolism_Homo sapiens_hsa006000.82263923
68Endometrial cancer_Homo sapiens_hsa052130.80604127
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79954196
70Acute myeloid leukemia_Homo sapiens_hsa052210.79864014
71Dilated cardiomyopathy_Homo sapiens_hsa054140.77260219
72Rheumatoid arthritis_Homo sapiens_hsa053230.76274881
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.75912456
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.75765293
75Measles_Homo sapiens_hsa051620.75641177
76Hippo signaling pathway_Homo sapiens_hsa043900.74357878
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.74299543
78Pathways in cancer_Homo sapiens_hsa052000.74266365
79Renal cell carcinoma_Homo sapiens_hsa052110.74082145
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74005279
81p53 signaling pathway_Homo sapiens_hsa041150.73476893
82Vitamin B6 metabolism_Homo sapiens_hsa007500.71896493
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71819960
84HTLV-I infection_Homo sapiens_hsa051660.70701606
85Endocytosis_Homo sapiens_hsa041440.70352109
86Influenza A_Homo sapiens_hsa051640.70247668
87Insulin signaling pathway_Homo sapiens_hsa049100.70133497
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69427633
89Hematopoietic cell lineage_Homo sapiens_hsa046400.68058122
90Sulfur metabolism_Homo sapiens_hsa009200.67370824
91Melanoma_Homo sapiens_hsa052180.67348710
92Insulin resistance_Homo sapiens_hsa049310.66574791
93Viral carcinogenesis_Homo sapiens_hsa052030.65609860
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65479500
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65444530
96Renin-angiotensin system_Homo sapiens_hsa046140.64977761
97Arginine biosynthesis_Homo sapiens_hsa002200.62357413
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61902095
99ErbB signaling pathway_Homo sapiens_hsa040120.60837082
100Prostate cancer_Homo sapiens_hsa052150.60669440
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59815399
102Chemokine signaling pathway_Homo sapiens_hsa040620.59620152
103VEGF signaling pathway_Homo sapiens_hsa043700.59446548
104B cell receptor signaling pathway_Homo sapiens_hsa046620.59399487
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59149030
106Rap1 signaling pathway_Homo sapiens_hsa040150.58979502
107AMPK signaling pathway_Homo sapiens_hsa041520.58616380
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.58539729
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57940986
110Tyrosine metabolism_Homo sapiens_hsa003500.55586119
111Estrogen signaling pathway_Homo sapiens_hsa049150.55284542
112Bile secretion_Homo sapiens_hsa049760.53931286
113Melanogenesis_Homo sapiens_hsa049160.53693381
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53681201
115Galactose metabolism_Homo sapiens_hsa000520.53605386
116Thyroid hormone synthesis_Homo sapiens_hsa049180.51606993
117Glutathione metabolism_Homo sapiens_hsa004800.49444022
118mTOR signaling pathway_Homo sapiens_hsa041500.49295963
119Colorectal cancer_Homo sapiens_hsa052100.48178628
120Basal cell carcinoma_Homo sapiens_hsa052170.47914279
121Hepatitis C_Homo sapiens_hsa051600.47542440
122Axon guidance_Homo sapiens_hsa043600.46694454
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46642930
124Glioma_Homo sapiens_hsa052140.46485477
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.46299109
126Herpes simplex infection_Homo sapiens_hsa051680.44763984
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43844782
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43687859
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42815482
130One carbon pool by folate_Homo sapiens_hsa006700.41157917
131GnRH signaling pathway_Homo sapiens_hsa049120.40897211
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39871353
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.39784723
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39231751
135Arachidonic acid metabolism_Homo sapiens_hsa005900.39084951
136PPAR signaling pathway_Homo sapiens_hsa033200.38744406
137Thyroid cancer_Homo sapiens_hsa052160.38731889

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