PLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.98691139
2synaptic vesicle maturation (GO:0016188)7.07504516
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.94471921
4* ensheathment of neurons (GO:0007272)6.85101527
5* axon ensheathment (GO:0008366)6.85101527
6* myelination (GO:0042552)6.81281708
7glutamate secretion (GO:0014047)6.47801917
8cellular potassium ion homeostasis (GO:0030007)5.97399572
9synaptic vesicle exocytosis (GO:0016079)5.91796119
10regulation of synaptic vesicle exocytosis (GO:2000300)5.60722461
11sodium ion export (GO:0071436)5.58395442
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53981677
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.47437371
14myelin maintenance (GO:0043217)5.26450549
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17792002
16negative regulation of neurotransmitter secretion (GO:0046929)5.14865663
17locomotory exploration behavior (GO:0035641)5.10550344
18cholesterol biosynthetic process (GO:0006695)5.06794830
19negative regulation of neurotransmitter transport (GO:0051589)4.91685480
20regulation of synaptic vesicle transport (GO:1902803)4.81873221
21regulation of neuronal synaptic plasticity (GO:0048168)4.77793979
22neurotransmitter secretion (GO:0007269)4.74640574
23regulation of collateral sprouting (GO:0048670)4.68635027
24oligodendrocyte differentiation (GO:0048709)4.62615482
25L-amino acid import (GO:0043092)4.58192175
26establishment of mitochondrion localization (GO:0051654)4.52748210
27potassium ion homeostasis (GO:0055075)4.51129793
28glycerophospholipid catabolic process (GO:0046475)4.50259280
29negative regulation of protein localization to cell surface (GO:2000009)4.50009421
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.48172248
31response to methylmercury (GO:0051597)4.47733927
32sterol biosynthetic process (GO:0016126)4.47251908
33postsynaptic membrane organization (GO:0001941)4.39851182
34potassium ion import (GO:0010107)4.37998777
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34733655
36creatine metabolic process (GO:0006600)4.33811847
37negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22664503
38regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15318693
39presynaptic membrane organization (GO:0097090)4.14169366
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13400649
41vocalization behavior (GO:0071625)4.12859055
42photoreceptor cell differentiation (GO:0046530)4.12275145
43eye photoreceptor cell differentiation (GO:0001754)4.12275145
44exploration behavior (GO:0035640)4.08062556
45amyloid precursor protein metabolic process (GO:0042982)4.06190670
46positive regulation of oligodendrocyte differentiation (GO:0048714)4.04639218
47long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.02374174
48response to redox state (GO:0051775)4.00480811
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00284122
50apical protein localization (GO:0045176)4.00083715
51positive regulation of synapse maturation (GO:0090129)3.96991164
52neurotransmitter transport (GO:0006836)3.96972639
53isoprenoid biosynthetic process (GO:0008299)3.96867449
54asymmetric protein localization (GO:0008105)3.96137007
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.84863925
56presynaptic membrane assembly (GO:0097105)3.81483584
57import into cell (GO:0098657)3.80992976
58synaptic transmission, glutamatergic (GO:0035249)3.80683600
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.76148643
60regulation of synaptic plasticity (GO:0048167)3.73152455
61acidic amino acid transport (GO:0015800)3.72303480
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.72087036
63neuromuscular process controlling balance (GO:0050885)3.66769905
64neurotransmitter-gated ion channel clustering (GO:0072578)3.66293044
65peripheral nervous system axon ensheathment (GO:0032292)3.63925355
66myelination in peripheral nervous system (GO:0022011)3.63925355
67glutamate receptor signaling pathway (GO:0007215)3.62586675
68peptidyl-tyrosine autophosphorylation (GO:0038083)3.62149127
69regulation of neurotransmitter levels (GO:0001505)3.60706133
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.60349211
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59868010
72regulation of glutamate receptor signaling pathway (GO:1900449)3.58485750
73cerebellar Purkinje cell differentiation (GO:0021702)3.56455176
74cellular sodium ion homeostasis (GO:0006883)3.56397816
75long-term synaptic potentiation (GO:0060291)3.55768231
76cell communication by electrical coupling (GO:0010644)3.54918361
77regulation of neurotransmitter secretion (GO:0046928)3.54716892
78positive regulation of membrane potential (GO:0045838)3.52167230
79neuron-neuron synaptic transmission (GO:0007270)3.51981885
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51930213
81negative regulation of inclusion body assembly (GO:0090084)3.51577324
82response to lipoprotein particle (GO:0055094)3.51488206
83positive regulation of dendritic spine development (GO:0060999)3.49841202
84amino acid import (GO:0043090)3.49219481
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48525398
86fatty-acyl-CoA biosynthetic process (GO:0046949)3.47736703
87* substantia nigra development (GO:0021762)3.45383762
88regulation of ARF protein signal transduction (GO:0032012)3.44277895
89protein palmitoylation (GO:0018345)3.41667727
90regulation of voltage-gated calcium channel activity (GO:1901385)3.38739273
91adhesion of symbiont to host cell (GO:0044650)3.38110294
92virion attachment to host cell (GO:0019062)3.38110294
93protein localization to synapse (GO:0035418)3.37854514
94membrane tubulation (GO:0097320)3.35626732
95regulation of neurotransmitter transport (GO:0051588)3.34456865
96L-glutamate transport (GO:0015813)3.31587906
97gamma-aminobutyric acid transport (GO:0015812)3.30737945
98fatty-acyl-CoA metabolic process (GO:0035337)3.29349953
99adult walking behavior (GO:0007628)3.29022400
100neuron cell-cell adhesion (GO:0007158)3.28887117
101negative regulation of dendrite morphogenesis (GO:0050774)3.27643100
102long-term memory (GO:0007616)3.27343514
103regulation of lipoprotein metabolic process (GO:0050746)3.26079708
104neuron remodeling (GO:0016322)3.25589105
105synaptic vesicle endocytosis (GO:0048488)3.24496000
106limb bud formation (GO:0060174)3.24105749
107negative regulation of axonogenesis (GO:0050771)3.21901597
108transmission of nerve impulse (GO:0019226)3.21199274
109magnesium ion transport (GO:0015693)3.20828761
110regulation of synapse structural plasticity (GO:0051823)3.18346980
111regulation of postsynaptic membrane potential (GO:0060078)3.17403404
112* long-chain fatty acid biosynthetic process (GO:0042759)3.17046459
113GPI anchor biosynthetic process (GO:0006506)3.15583405
114regulation of synapse maturation (GO:0090128)3.13580370
115cerebral cortex radially oriented cell migration (GO:0021799)3.11423299
116regulation of dendritic spine development (GO:0060998)3.11134275
117regulation of synaptic transmission (GO:0050804)3.10744568
118very long-chain fatty acid metabolic process (GO:0000038)3.09371188
119regulation of dendritic spine morphogenesis (GO:0061001)3.07730813
120GPI anchor metabolic process (GO:0006505)3.07528918
121regulation of synaptic transmission, glutamatergic (GO:0051966)3.05846839
122cytoskeletal anchoring at plasma membrane (GO:0007016)3.04715008
123positive regulation of Rap GTPase activity (GO:0032854)3.04086743
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02404728
125regulation of vesicle fusion (GO:0031338)3.00143172
126cellular response to epinephrine stimulus (GO:0071872)2.98171985
127astrocyte differentiation (GO:0048708)2.97684796
128auditory behavior (GO:0031223)2.97049935
129regulation of synaptic transmission, GABAergic (GO:0032228)2.96444160
130neurotransmitter uptake (GO:0001504)2.96413889
131glycosylceramide metabolic process (GO:0006677)2.95648784
132membrane depolarization during action potential (GO:0086010)2.92382916
133layer formation in cerebral cortex (GO:0021819)2.92339973
134amyloid precursor protein catabolic process (GO:0042987)2.91587649
135phosphorelay signal transduction system (GO:0000160)2.90807840
136positive regulation of neurotransmitter secretion (GO:0001956)2.90668360
137positive regulation of action potential (GO:0045760)2.90616173
138membrane assembly (GO:0071709)2.89809949
139membrane depolarization (GO:0051899)2.89416099
140peripheral nervous system development (GO:0007422)2.86948307
141neuronal action potential propagation (GO:0019227)2.84456607
142negative regulation of axon extension (GO:0030517)2.82845843
143preassembly of GPI anchor in ER membrane (GO:0016254)2.82814821
144negative regulation of JUN kinase activity (GO:0043508)2.82718046
145neuronal ion channel clustering (GO:0045161)2.82674881
146nucleotide transmembrane transport (GO:1901679)2.81295334
147peptidyl-cysteine modification (GO:0018198)2.78588782
148leukocyte migration involved in inflammatory response (GO:0002523)2.76055335
149protein neddylation (GO:0045116)2.75600465
150thioester biosynthetic process (GO:0035384)2.74853962
151acyl-CoA biosynthetic process (GO:0071616)2.74853962
152negative regulation of execution phase of apoptosis (GO:1900118)2.73671446
153enteric nervous system development (GO:0048484)2.71921041
154response to epinephrine (GO:0071871)2.70607835
155organ growth (GO:0035265)2.70504468
156positive regulation of glial cell differentiation (GO:0045687)2.70381800
157nerve growth factor signaling pathway (GO:0038180)2.69770983
158iron coordination entity transport (GO:1901678)2.64046414
159positive regulation of cellular amine metabolic process (GO:0033240)2.62662407
160positive regulation of gliogenesis (GO:0014015)2.54982941
161detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.54089986
162detection of temperature stimulus involved in sensory perception (GO:0050961)2.54089986
163glial cell differentiation (GO:0010001)2.54019394
164cellular response to monoamine stimulus (GO:0071868)2.53934767
165cellular response to catecholamine stimulus (GO:0071870)2.53934767
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49193561
167regulation of dopamine metabolic process (GO:0042053)2.47673328
168regulation of catecholamine metabolic process (GO:0042069)2.47673328
169heme transport (GO:0015886)2.47529728
170positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.46834265
171cranial nerve development (GO:0021545)2.46463846
172cerebellar granule cell differentiation (GO:0021707)2.46448783
173neuron recognition (GO:0008038)2.44431729
174response to lead ion (GO:0010288)2.41553100
175adhesion of symbiont to host (GO:0044406)2.40549649
176microtubule polymerization or depolymerization (GO:0031109)2.40006570
177* axon ensheathment in central nervous system (GO:0032291)10.1836271
178* central nervous system myelination (GO:0022010)10.1836271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.29150828
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.26560997
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80008039
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.76145456
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66474580
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.66134177
7EZH2_22144423_ChIP-Seq_EOC_Human2.47003871
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39526008
9TAF15_26573619_Chip-Seq_HEK293_Human2.38161004
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36757849
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35668450
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27477341
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12653434
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11868089
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11390347
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.05501377
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02693789
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00383505
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00383505
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99855725
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97075567
22AR_21572438_ChIP-Seq_LNCaP_Human1.95467508
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92686814
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91110726
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.89126659
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87477221
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86871183
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.83700433
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81677335
30ER_23166858_ChIP-Seq_MCF-7_Human1.81229677
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73867460
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69032237
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68531617
34VDR_22108803_ChIP-Seq_LS180_Human1.66803815
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.62741254
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62084854
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61897880
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61423872
39DROSHA_22980978_ChIP-Seq_HELA_Human1.60469091
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56761680
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.55415825
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.55364920
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52496079
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50694837
45KDM2B_26808549_Chip-Seq_K562_Human1.49986590
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48305019
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47910853
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47383438
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46424889
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43807788
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40389093
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39143039
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.39002093
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38245443
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38182098
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.35965359
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35814089
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35731400
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34796158
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.34622800
61FUS_26573619_Chip-Seq_HEK293_Human1.32042398
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31645931
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31580542
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31147210
65P300_19829295_ChIP-Seq_ESCs_Human1.30576296
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.29396522
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.26247434
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26119067
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26033156
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.24277675
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22278172
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21311201
73AR_19668381_ChIP-Seq_PC3_Human1.20541444
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20526487
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20526487
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20169666
77REST_21632747_ChIP-Seq_MESCs_Mouse1.19116488
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17790230
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16032932
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.14351211
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14271307
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13108993
83STAT3_23295773_ChIP-Seq_U87_Human1.12469496
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.11764378
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.10619058
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08887786
87EOMES_21245162_ChIP-Seq_HESCs_Human1.08522411
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08449075
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07852460
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.07740772
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.07657313
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07031793
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05997738
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05863979
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05013900
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.04587161
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04352479
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03439069
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02774023
100HTT_18923047_ChIP-ChIP_STHdh_Human1.02701320
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01805030
102P300_18555785_Chip-Seq_ESCs_Mouse1.01401341
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01009905
104RNF2_27304074_Chip-Seq_NSC_Mouse1.00613577
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00109861
106TCF4_23295773_ChIP-Seq_U87_Human0.99801699
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99617598
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99582525
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98922460
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98112091
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97981585
112* SMAD4_21799915_ChIP-Seq_A2780_Human0.97832196
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97744599
114REST_18959480_ChIP-ChIP_MESCs_Mouse0.97692748
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95697860
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94957340
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.94858744
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.93988354
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92776994
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.92664823
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.92224246
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91902993
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91862770
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91566275
125NANOG_19829295_ChIP-Seq_ESCs_Human0.91044097
126SOX2_19829295_ChIP-Seq_ESCs_Human0.91044097
127SOX9_26525672_Chip-Seq_HEART_Mouse0.90840204
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.89925103
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89052047
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88839997
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88303218
132AHR_22903824_ChIP-Seq_MCF-7_Human0.87818300
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87781471
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.87172937
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87088342
136TBL1_22424771_ChIP-Seq_293T_Human0.86870918
137OCT4_19829295_ChIP-Seq_ESCs_Human0.86738099
138TP53_16413492_ChIP-PET_HCT116_Human0.86181951
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.86134652
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85752949
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85707540
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84947995
143CTCF_27219007_Chip-Seq_Bcells_Human0.84894078
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83846806
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81290379
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.81119790
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.80822782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.43679298
2MP0003880_abnormal_central_pattern4.19754346
3MP0003950_abnormal_plasma_membrane3.40588326
4MP0004270_analgesia3.29078889
5MP0004742_abnormal_vestibular_system2.89216570
6MP0003329_amyloid_beta_deposits2.84511009
7MP0004885_abnormal_endolymph2.76465735
8MP0003136_yellow_coat_color2.68204542
9MP0005171_absent_coat_pigmentation2.67134552
10MP0001905_abnormal_dopamine_level2.62526763
11* MP0002272_abnormal_nervous_system2.50504045
12* MP0003690_abnormal_glial_cell2.42947786
13MP0004142_abnormal_muscle_tone2.39481981
14MP0001485_abnormal_pinna_reflex2.29321302
15MP0005409_darkened_coat_color2.28866828
16* MP0003634_abnormal_glial_cell2.26544885
17MP0000778_abnormal_nervous_system2.25817710
18* MP0001486_abnormal_startle_reflex2.23899515
19* MP0002064_seizures2.23111589
20MP0004859_abnormal_synaptic_plasticity2.16368413
21MP0005423_abnormal_somatic_nervous2.03536814
22MP0005410_abnormal_fertilization1.98937461
23MP0009046_muscle_twitch1.92552680
24MP0003632_abnormal_nervous_system1.92327173
25MP0009745_abnormal_behavioral_response1.89199735
26MP0003635_abnormal_synaptic_transmissio1.85538036
27MP0000462_abnormal_digestive_system1.82933019
28MP0001984_abnormal_olfaction1.82557875
29* MP0002229_neurodegeneration1.79486250
30MP0003879_abnormal_hair_cell1.78935474
31MP0002734_abnormal_mechanical_nocicepti1.75257613
32MP0004811_abnormal_neuron_physiology1.74281564
33MP0010678_abnormal_skin_adnexa1.72414922
34MP0004381_abnormal_hair_follicle1.65718136
35MP0004043_abnormal_pH_regulation1.62447893
36MP0009780_abnormal_chondrocyte_physiolo1.59374726
37MP0004134_abnormal_chest_morphology1.59341551
38MP0000383_abnormal_hair_follicle1.59274844
39MP0005451_abnormal_body_composition1.59189089
40MP0005646_abnormal_pituitary_gland1.57011115
41MP0001440_abnormal_grooming_behavior1.54761779
42MP0005551_abnormal_eye_electrophysiolog1.52462624
43MP0003631_nervous_system_phenotype1.50594036
44MP0002572_abnormal_emotion/affect_behav1.49771555
45MP0003787_abnormal_imprinting1.48797168
46MP0000955_abnormal_spinal_cord1.48516781
47MP0000604_amyloidosis1.47370265
48* MP0002882_abnormal_neuron_morphology1.39188016
49MP0002063_abnormal_learning/memory/cond1.38568166
50MP0008260_abnormal_autophagy1.32681052
51MP0003633_abnormal_nervous_system1.31225863
52MP0001970_abnormal_pain_threshold1.31094705
53MP0001963_abnormal_hearing_physiology1.30037597
54MP0002067_abnormal_sensory_capabilities1.28641428
55MP0003806_abnormal_nucleotide_metabolis1.28103523
56* MP0002066_abnormal_motor_capabilities/c1.27759249
57MP0004147_increased_porphyrin_level1.23365986
58MP0003123_paternal_imprinting1.18353926
59MP0000747_muscle_weakness1.17690645
60* MP0002752_abnormal_somatic_nervous1.15062213
61MP0005167_abnormal_blood-brain_barrier1.14753997
62MP0003195_calcinosis1.14209631
63MP0005623_abnormal_meninges_morphology1.13203105
64MP0001299_abnormal_eye_distance/1.11828242
65MP0001346_abnormal_lacrimal_gland1.09376456
66MP0000566_synostosis1.09351192
67MP0001661_extended_life_span1.08847922
68MP0004145_abnormal_muscle_electrophysio1.08348608
69MP0002733_abnormal_thermal_nociception1.06499219
70MP0000647_abnormal_sebaceous_gland0.99808974
71MP0003938_abnormal_ear_development0.99071365
72MP0006276_abnormal_autonomic_nervous0.98856210
73MP0001968_abnormal_touch/_nociception0.97398165
74MP0003075_altered_response_to0.97390259
75* MP0001529_abnormal_vocalization0.96874666
76MP0003122_maternal_imprinting0.96556828
77MP0001851_eye_inflammation0.94793873
78MP0000762_abnormal_tongue_morphology0.94570739
79MP0001177_atelectasis0.93443800
80* MP0005195_abnormal_posterior_eye0.93387521
81MP0008874_decreased_physiological_sensi0.88931990
82MP0003937_abnormal_limbs/digits/tail_de0.87748742
83MP0002295_abnormal_pulmonary_circulatio0.86790108
84* MP0008569_lethality_at_weaning0.85802924
85MP0002822_catalepsy0.85438018
86MP0000026_abnormal_inner_ear0.85259374
87MP0000569_abnormal_digit_pigmentation0.84417749
88MP0005058_abnormal_lysosome_morphology0.83840830
89* MP0004924_abnormal_behavior0.83680595
90* MP0005386_behavior/neurological_phenoty0.83680595
91MP0001501_abnormal_sleep_pattern0.82998372
92* MP0002152_abnormal_brain_morphology0.82707684
93MP0005408_hypopigmentation0.82428009
94MP0002735_abnormal_chemical_nociception0.82339993
95MP0005253_abnormal_eye_physiology0.80635034
96MP0002736_abnormal_nociception_after0.80341555
97MP0002638_abnormal_pupillary_reflex0.78971182
98MP0002184_abnormal_innervation0.77215756
99MP0006072_abnormal_retinal_apoptosis0.74177409
100MP0002557_abnormal_social/conspecific_i0.71812413
101MP0002090_abnormal_vision0.71610533
102MP0001348_abnormal_lacrimal_gland0.71423753
103MP0001502_abnormal_circadian_rhythm0.70655855
104MP0000579_abnormal_nail_morphology0.70607565
105MP0000467_abnormal_esophagus_morphology0.69588259
106MP0006082_CNS_inflammation0.67384140
107MP0004185_abnormal_adipocyte_glucose0.67357780
108MP0001986_abnormal_taste_sensitivity0.66266316
109MP0004036_abnormal_muscle_relaxation0.65908496
110MP0005645_abnormal_hypothalamus_physiol0.64075141
111MP0002069_abnormal_eating/drinking_beha0.63593206
112MP0003137_abnormal_impulse_conducting0.62541044
113MP0001727_abnormal_embryo_implantation0.60591506
114MP0000631_abnormal_neuroendocrine_gland0.60375788
115MP0008438_abnormal_cutaneous_collagen0.60054728
116MP0002133_abnormal_respiratory_system0.59101267
117MP0002909_abnormal_adrenal_gland0.59097181
118MP0005535_abnormal_body_temperature0.58554296
119MP0003045_fibrosis0.58065793
120* MP0010769_abnormal_survival0.55349693
121MP0001943_abnormal_respiration0.53125947
122MP0000639_abnormal_adrenal_gland0.51943173
123* MP0002082_postnatal_lethality0.51562707
124* MP0010770_preweaning_lethality0.51562707
125* MP0010768_mortality/aging0.51512726
126MP0003956_abnormal_body_size0.47680163
127MP0005388_respiratory_system_phenotype0.47047055
128MP0003172_abnormal_lysosome_physiology0.46102792
129MP0002089_abnormal_postnatal_growth/wei0.45910543
130* MP0003861_abnormal_nervous_system0.43345443
131MP0004130_abnormal_muscle_cell0.42466789
132MP0008872_abnormal_physiological_respon0.42433859
133MP0001731_abnormal_postnatal_growth0.42044523
134MP0003283_abnormal_digestive_organ0.40835167

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.57609325
2Focal seizures (HP:0007359)5.26564720
3Parakeratosis (HP:0001036)5.10515695
4Sensory axonal neuropathy (HP:0003390)4.97175600
5Peripheral hypomyelination (HP:0007182)4.84256133
6Cerebral inclusion bodies (HP:0100314)4.72514407
7Febrile seizures (HP:0002373)4.69657841
8Abnormality of binocular vision (HP:0011514)4.69180796
9Diplopia (HP:0000651)4.69180796
10Atonic seizures (HP:0010819)4.46959811
11Epileptic encephalopathy (HP:0200134)4.37318473
12Cerebral hypomyelination (HP:0006808)4.22211590
13Onion bulb formation (HP:0003383)4.00096801
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.95497426
15Supranuclear gaze palsy (HP:0000605)3.82005851
16Generalized tonic-clonic seizures (HP:0002069)3.58041628
17Abnormal auditory evoked potentials (HP:0006958)3.57113840
18Termporal pattern (HP:0011008)3.56708183
19Insidious onset (HP:0003587)3.56708183
20Abnormal eating behavior (HP:0100738)3.51099134
21Alacrima (HP:0000522)3.47799652
22Postural instability (HP:0002172)3.47037118
23Intention tremor (HP:0002080)3.44169214
24Increased serum pyruvate (HP:0003542)3.34760023
25Abnormality of glycolysis (HP:0004366)3.34760023
26Urinary bladder sphincter dysfunction (HP:0002839)3.13647667
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.13507486
28Progressive cerebellar ataxia (HP:0002073)3.06820714
29Visual hallucinations (HP:0002367)3.06646317
30Absence seizures (HP:0002121)3.06607567
31Obstructive sleep apnea (HP:0002870)3.06251734
32Retinal dysplasia (HP:0007973)3.03049649
33Truncal ataxia (HP:0002078)3.00717978
34Dialeptic seizures (HP:0011146)2.99092135
35Slow saccadic eye movements (HP:0000514)2.98117758
36Hemiplegia (HP:0002301)2.97339827
37Torticollis (HP:0000473)2.97047205
38Limb dystonia (HP:0002451)2.95585919
39* Degeneration of the lateral corticospinal tracts (HP:0002314)2.95580938
40* Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95580938
41Neuronal loss in central nervous system (HP:0002529)2.91144623
42Myokymia (HP:0002411)2.90915664
43Ankle clonus (HP:0011448)2.90730229
44Papilledema (HP:0001085)2.89198873
45Hypoplastic pelvis (HP:0008839)2.88324806
46Mutism (HP:0002300)2.86793059
47Congenital ichthyosiform erythroderma (HP:0007431)2.86540249
48Tetraplegia (HP:0002445)2.84920798
49Impaired vibration sensation in the lower limbs (HP:0002166)2.82468759
50Anteriorly placed anus (HP:0001545)2.82372480
51Dysdiadochokinesis (HP:0002075)2.78680735
52Premature skin wrinkling (HP:0100678)2.74961615
53* Spastic gait (HP:0002064)2.74263504
54Decreased lacrimation (HP:0000633)2.73425349
55Segmental peripheral demyelination/remyelination (HP:0003481)2.72481804
56Cerebral hemorrhage (HP:0001342)2.71964689
57Spastic paraparesis (HP:0002313)2.71715121
58Akinesia (HP:0002304)2.71700672
59* Dysmetria (HP:0001310)2.70490471
60Absent septum pellucidum (HP:0001331)2.68915630
61CNS hypomyelination (HP:0003429)2.66749595
62Annular pancreas (HP:0001734)2.66402444
63Depression (HP:0000716)2.65451354
64Insomnia (HP:0100785)2.65016317
65Hemiparesis (HP:0001269)2.60001523
66Sleep apnea (HP:0010535)2.59239146
67Clumsiness (HP:0002312)2.58517747
68Delusions (HP:0000746)2.56801324
69Thickened helices (HP:0000391)2.56765527
70Apathy (HP:0000741)2.56239673
71Increased circulating renin level (HP:0000848)2.53359633
72Morphological abnormality of the inner ear (HP:0011390)2.53314074
73Bradykinesia (HP:0002067)2.53212237
74* Lower limb muscle weakness (HP:0007340)2.51258408
75Rigidity (HP:0002063)2.51174324
76Abnormality of the periventricular white matter (HP:0002518)2.47624258
77* Leukodystrophy (HP:0002415)2.46797324
78Status epilepticus (HP:0002133)2.46748757
79Autoamputation (HP:0001218)2.46465447
80Pheochromocytoma (HP:0002666)2.46109650
81Rapidly progressive (HP:0003678)2.45324533
82Split foot (HP:0001839)2.42426581
83Bundle branch block (HP:0011710)2.42226327
84Anxiety (HP:0000739)2.41746201
85Focal dystonia (HP:0004373)2.36755446
86Poor eye contact (HP:0000817)2.34039553
87White forelock (HP:0002211)2.31081672
88Metabolic alkalosis (HP:0200114)2.29943919
89Diminished motivation (HP:0000745)2.27725815
90Patchy hypopigmentation of hair (HP:0011365)2.27561477
91Coronal craniosynostosis (HP:0004440)2.27106481
92Abnormality of the septum pellucidum (HP:0007375)2.26275083
93Hypomagnesemia (HP:0002917)2.25733738
94Hepatosplenomegaly (HP:0001433)2.25169022
95Craniofacial dystonia (HP:0012179)2.25014459
96Epileptiform EEG discharges (HP:0011182)2.24245341
97Aplasia involving bones of the upper limbs (HP:0009823)2.22061792
98Aplasia of the phalanges of the hand (HP:0009802)2.22061792
99Aplasia involving bones of the extremities (HP:0009825)2.22061792
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21037435
101Abnormality of the lower motor neuron (HP:0002366)2.18398912
102Neuroendocrine neoplasm (HP:0100634)2.17365525
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.16971019
104Turricephaly (HP:0000262)2.14635443
105Hypoplasia of the iris (HP:0007676)2.13987958
106Spastic tetraparesis (HP:0001285)2.13384377
107Cupped ear (HP:0000378)2.12728060
108Renal Fanconi syndrome (HP:0001994)2.11775661
109Impaired smooth pursuit (HP:0007772)2.10937145
110* Choreoathetosis (HP:0001266)2.10873618
111Foot dorsiflexor weakness (HP:0009027)2.10739502
112Infantile muscular hypotonia (HP:0008947)2.10420767
113Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.09483551
114Esophageal atresia (HP:0002032)2.08417607
115Methylmalonic acidemia (HP:0002912)2.06836710
116Partial agenesis of the corpus callosum (HP:0001338)2.05776451
117Hypokalemic alkalosis (HP:0001949)2.05636051
118Poor speech (HP:0002465)2.04499614
119Bronchomalacia (HP:0002780)2.03322080
120Impaired vibratory sensation (HP:0002495)2.03213315
121Impaired social interactions (HP:0000735)2.02269420
122Abnormal social behavior (HP:0012433)2.02269420
123Muscle fiber splitting (HP:0003555)2.01763653
124Abnormality of saccadic eye movements (HP:0000570)2.01547281
125Adrenal hypoplasia (HP:0000835)1.98725349
126Megalencephaly (HP:0001355)1.98646239
127Axonal loss (HP:0003447)1.97916100
128Partial duplication of thumb phalanx (HP:0009944)1.97549341
129Decreased motor nerve conduction velocity (HP:0003431)1.97316623
130Synostosis involving the elbow (HP:0003938)1.97218845
131Humeroradial synostosis (HP:0003041)1.97218845
132Memory impairment (HP:0002354)1.96646087
133Abnormality of ocular smooth pursuit (HP:0000617)1.96200096
134* Abnormality of the corticospinal tract (HP:0002492)1.96078996
135Paraparesis (HP:0002385)1.95309842
136Clonus (HP:0002169)1.94010226
137Amyotrophic lateral sclerosis (HP:0007354)1.93269912
138EEG with generalized epileptiform discharges (HP:0011198)1.92832503
139Action tremor (HP:0002345)1.92452795
140Abnormality of the foot musculature (HP:0001436)1.90526161
141Urinary incontinence (HP:0000020)1.87773044
142Vaginal atresia (HP:0000148)1.87772117
143Acute necrotizing encephalopathy (HP:0006965)1.87288223
144Septo-optic dysplasia (HP:0100842)1.87077325
1453-Methylglutaconic aciduria (HP:0003535)1.86726675
146Anomalous pulmonary venous return (HP:0010772)1.86238893
147Broad-based gait (HP:0002136)1.86138518
148Stereotypic behavior (HP:0000733)1.84983457
149Abnormality of the middle phalanges of the toes (HP:0010183)1.83352833
150Hammertoe (HP:0001765)1.83296292
151Hypophosphatemic rickets (HP:0004912)1.82774157
152Overriding aorta (HP:0002623)1.82549676
153Gowers sign (HP:0003391)1.81481004
154Erythroderma (HP:0001019)1.80869912
155Genital tract atresia (HP:0001827)1.77213267
156Generalized myoclonic seizures (HP:0002123)1.77051089
157Focal motor seizures (HP:0011153)1.76405732
158Steppage gait (HP:0003376)1.75378951
159Distal sensory impairment (HP:0002936)1.73331073
160Hyporeflexia of lower limbs (HP:0002600)1.72672266
161Urinary urgency (HP:0000012)1.72471829
162Postnatal microcephaly (HP:0005484)1.68816233
163Peripheral demyelination (HP:0011096)1.67978351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.41491452
2OXSR14.51267453
3NTRK34.22820896
4EPHB13.50724352
5DAPK23.01615052
6PKN12.78380216
7BCR2.64140833
8WNK42.52191452
9MAPKAPK52.51383273
10PBK2.50456707
11TNIK2.38589542
12MINK12.31486356
13CDK192.29819793
14PRKD32.28613655
15MET2.15813064
16MAP3K92.11634904
17FGFR22.09366161
18CAMKK12.08253994
19UHMK11.90914870
20WNK11.88748837
21LIMK11.87057200
22PNCK1.83371481
23CSNK1G31.75416283
24CSNK1A1L1.66909987
25NEK61.62539649
26PRPF4B1.60058902
27NTRK11.58231732
28TESK21.54082118
29CAMK2B1.53263876
30ROCK21.50719189
31RIPK11.49345893
32PLK21.48742788
33MST41.45703614
34ICK1.44067434
35LATS21.42460268
36CLK11.42122743
37CASK1.42121741
38FGR1.37600245
39CSNK1G11.35888265
40EPHA41.32570591
41TYRO31.32380899
42CSNK1G21.31537015
43CAMK2D1.29863464
44PAK61.23501322
45SGK2231.17180188
46SGK4941.17180188
47PINK11.16297861
48CAMK11.13852095
49RIPK41.10135311
50ALK1.09596272
51GRK51.08833335
52PRKCG1.06940991
53MARK11.01164641
54SGK21.01061887
55DYRK20.99397708
56CAMK2G0.98251373
57DAPK10.94689676
58CAMKK20.93657062
59SGK30.89465307
60IRAK20.86593718
61SGK10.86051655
62MAPK150.86038679
63CAMK2A0.85892187
64PRKCQ0.85664380
65PAK30.85326941
66MARK20.85194566
67MUSK0.82134859
68CDK50.81973309
69CDK140.81367696
70DAPK30.80586479
71MAPK120.80445298
72SIK20.80426871
73STK380.74549598
74ARAF0.74533885
75FES0.73185748
76PRKD10.72085940
77CDK150.70754750
78BMPR1B0.70157566
79BRSK10.68816565
80RPS6KA30.66028301
81MAPK130.65614700
82CDK180.65450839
83PHKG20.65383417
84PHKG10.65383417
85PRKCE0.65037439
86CDK11A0.63168958
87PDPK10.61325038
88FYN0.57902317
89KSR10.57693131
90ERBB40.56528972
91PRKCZ0.54209847
92TNK20.53942937
93CAMK40.53881484
94RPS6KA50.51550191
95NTRK20.51445294
96MAP3K40.50092399
97RET0.49728297
98KSR20.48675398
99PRKG10.48266888
100CSNK1D0.47736451
101MAP3K130.47687774
102LMTK20.47271808
103GSK3A0.46875979
104MAP3K110.46087736
105MAP2K20.44699225
106ADRBK20.42828795
107GRK70.42601657
108TRPM70.42330383
109BRAF0.42015150
110CSNK1A10.41635064
111IRAK10.40953141
112PRKCH0.39814190
113PDK20.38154967
114MAP2K40.38022039
115PRKACB0.37961026
116ERBB20.37885846
117CAMK1G0.37540807
118RAF10.37254389
119PDGFRB0.37115709
120PIK3CA0.36964590
121STK110.35459619
122PAK10.34077937
123MAP3K10.33323589
124PRKCA0.32987633
125MKNK10.32589758
126SRC0.31188272
127INSR0.30369423
128PRKACA0.30295493
129DMPK0.30227548
130PRKCB0.29540647
131OBSCN0.29434701
132MAP3K20.28714439
133PDK10.28621618
134BMPR20.28338434
135PTK2B0.27758612
136ROCK10.25639955
137MAPK70.24675521
138DYRK1A0.24645900
139CSNK1E0.24435233
140GRK10.23946481
141ITK0.23142101
142CSK0.22539999
143MAPK100.22431847

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.57493947
2Steroid biosynthesis_Homo sapiens_hsa001004.72826729
3Fatty acid elongation_Homo sapiens_hsa000624.38834293
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49464639
5Ether lipid metabolism_Homo sapiens_hsa005653.18571311
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84526425
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52795295
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.51671475
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44487406
10Insulin secretion_Homo sapiens_hsa049112.34977946
11Oxidative phosphorylation_Homo sapiens_hsa001902.16130712
12Sulfur metabolism_Homo sapiens_hsa009201.93623341
13Vitamin B6 metabolism_Homo sapiens_hsa007501.93293405
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85675024
15Protein export_Homo sapiens_hsa030601.84373516
16Axon guidance_Homo sapiens_hsa043601.76526970
17Sphingolipid metabolism_Homo sapiens_hsa006001.74429480
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70585968
19Linoleic acid metabolism_Homo sapiens_hsa005911.63888932
20Histidine metabolism_Homo sapiens_hsa003401.58196774
21Parkinsons disease_Homo sapiens_hsa050121.54077693
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49449618
23Alzheimers disease_Homo sapiens_hsa050101.47454463
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47239258
25Butanoate metabolism_Homo sapiens_hsa006501.45296107
26Glutamatergic synapse_Homo sapiens_hsa047241.40472384
27Oxytocin signaling pathway_Homo sapiens_hsa049211.37951364
28Calcium signaling pathway_Homo sapiens_hsa040201.37937987
29GABAergic synapse_Homo sapiens_hsa047271.36530975
30Serotonergic synapse_Homo sapiens_hsa047261.35739889
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35624561
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30349512
33Estrogen signaling pathway_Homo sapiens_hsa049151.28850539
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28420860
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27540373
36beta-Alanine metabolism_Homo sapiens_hsa004101.26680283
37Bile secretion_Homo sapiens_hsa049761.23913730
38Nitrogen metabolism_Homo sapiens_hsa009101.21568643
39GnRH signaling pathway_Homo sapiens_hsa049121.17113159
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11880884
41Long-term depression_Homo sapiens_hsa047301.11796999
42Renal cell carcinoma_Homo sapiens_hsa052111.07101650
43Collecting duct acid secretion_Homo sapiens_hsa049661.06166664
44Arginine and proline metabolism_Homo sapiens_hsa003301.05988494
45Olfactory transduction_Homo sapiens_hsa047401.05658635
46Morphine addiction_Homo sapiens_hsa050321.05601808
47Glioma_Homo sapiens_hsa052141.04216579
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00468600
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99982433
50Melanogenesis_Homo sapiens_hsa049160.97856509
51Vibrio cholerae infection_Homo sapiens_hsa051100.95432831
52Thyroid hormone synthesis_Homo sapiens_hsa049180.94993059
53Inositol phosphate metabolism_Homo sapiens_hsa005620.90317943
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.87805954
55Oocyte meiosis_Homo sapiens_hsa041140.86709256
56Tight junction_Homo sapiens_hsa045300.84997808
57Rap1 signaling pathway_Homo sapiens_hsa040150.84259151
58Cardiac muscle contraction_Homo sapiens_hsa042600.83835313
59Arachidonic acid metabolism_Homo sapiens_hsa005900.81081018
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80943097
61Cocaine addiction_Homo sapiens_hsa050300.80398804
62Nicotine addiction_Homo sapiens_hsa050330.78243628
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77392923
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76661592
65Huntingtons disease_Homo sapiens_hsa050160.74821101
66Circadian entrainment_Homo sapiens_hsa047130.74764443
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74062387
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73182304
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.72469892
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.71459433
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71419632
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71398979
73Rheumatoid arthritis_Homo sapiens_hsa053230.71266534
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.70849914
75Salivary secretion_Homo sapiens_hsa049700.70508676
76Fatty acid metabolism_Homo sapiens_hsa012120.70385535
77Phototransduction_Homo sapiens_hsa047440.68313803
78Ovarian steroidogenesis_Homo sapiens_hsa049130.68184699
79Glutathione metabolism_Homo sapiens_hsa004800.68140493
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.68127906
81Ras signaling pathway_Homo sapiens_hsa040140.67626339
82MAPK signaling pathway_Homo sapiens_hsa040100.66151330
83Cholinergic synapse_Homo sapiens_hsa047250.66134945
84Endocytosis_Homo sapiens_hsa041440.64652941
85Dopaminergic synapse_Homo sapiens_hsa047280.63231625
86Autoimmune thyroid disease_Homo sapiens_hsa053200.62857915
87Gastric acid secretion_Homo sapiens_hsa049710.59955343
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59924168
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57324726
90Propanoate metabolism_Homo sapiens_hsa006400.57001590
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56861555
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56756179
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.56635050
94Synaptic vesicle cycle_Homo sapiens_hsa047210.55507482
95VEGF signaling pathway_Homo sapiens_hsa043700.55066046
96Type II diabetes mellitus_Homo sapiens_hsa049300.54887831
97Circadian rhythm_Homo sapiens_hsa047100.54413762
98Arginine biosynthesis_Homo sapiens_hsa002200.54177932
99Lysosome_Homo sapiens_hsa041420.53446211
100Mineral absorption_Homo sapiens_hsa049780.53334462
101Pancreatic secretion_Homo sapiens_hsa049720.52906560
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51981033
103Dorso-ventral axis formation_Homo sapiens_hsa043200.50909802
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50392684
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49397616
106ErbB signaling pathway_Homo sapiens_hsa040120.48377034
107Peroxisome_Homo sapiens_hsa041460.46073249
108Phagosome_Homo sapiens_hsa041450.45153783
109Glucagon signaling pathway_Homo sapiens_hsa049220.44394534
110Renin secretion_Homo sapiens_hsa049240.44133579
111Hedgehog signaling pathway_Homo sapiens_hsa043400.43383389
112Fatty acid biosynthesis_Homo sapiens_hsa000610.42312518
113Gap junction_Homo sapiens_hsa045400.41658006
114Metabolic pathways_Homo sapiens_hsa011000.40433719
115ABC transporters_Homo sapiens_hsa020100.39894391
116Taste transduction_Homo sapiens_hsa047420.39814066
117Choline metabolism in cancer_Homo sapiens_hsa052310.39188624
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38097169
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37785119
120Amphetamine addiction_Homo sapiens_hsa050310.37272396
121Folate biosynthesis_Homo sapiens_hsa007900.36611678
122Prion diseases_Homo sapiens_hsa050200.35807997
123Dilated cardiomyopathy_Homo sapiens_hsa054140.35536588
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34357446
125Wnt signaling pathway_Homo sapiens_hsa043100.33966915
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33825809
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33232727
128Vitamin digestion and absorption_Homo sapiens_hsa049770.32290594
129Hippo signaling pathway_Homo sapiens_hsa043900.32163976
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32139336
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31022798
132ECM-receptor interaction_Homo sapiens_hsa045120.30927395
133Endometrial cancer_Homo sapiens_hsa052130.30796155
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30180748
135cAMP signaling pathway_Homo sapiens_hsa040240.29870969
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28164355
137Alcoholism_Homo sapiens_hsa050340.26921886
138Tyrosine metabolism_Homo sapiens_hsa003500.26093382
139Chemical carcinogenesis_Homo sapiens_hsa052040.26088765
140Long-term potentiation_Homo sapiens_hsa047200.25698060
141Malaria_Homo sapiens_hsa051440.25291371
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24422504

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