PLP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.90720595
2protein maturation by protein folding (GO:0022417)4.48991858
3COPI coating of Golgi vesicle (GO:0048205)4.12323285
4Golgi transport vesicle coating (GO:0048200)4.12323285
5viral transcription (GO:0019083)4.02847419
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.98159387
7formation of translation preinitiation complex (GO:0001731)3.91535189
8translational termination (GO:0006415)3.90791567
9membrane raft organization (GO:0031579)3.84188150
10maturation of SSU-rRNA (GO:0030490)3.74361969
11ribosomal small subunit biogenesis (GO:0042274)3.55056808
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.48674347
13translational elongation (GO:0006414)3.46180241
14protein targeting to ER (GO:0045047)3.37570701
15regulation of metalloenzyme activity (GO:0048552)3.37231944
16cotranslational protein targeting to membrane (GO:0006613)3.35396353
17DNA strand elongation involved in DNA replication (GO:0006271)3.34531732
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31953149
19telomere maintenance via semi-conservative replication (GO:0032201)3.31328645
20translational initiation (GO:0006413)3.26098869
21barbed-end actin filament capping (GO:0051016)3.25941002
22pyrimidine nucleoside salvage (GO:0043097)3.21898909
23pyrimidine-containing compound salvage (GO:0008655)3.21898909
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21550344
25hemidesmosome assembly (GO:0031581)3.19151925
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19063873
27pinocytosis (GO:0006907)3.19009764
28DNA strand elongation (GO:0022616)3.18730183
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17544242
30viral life cycle (GO:0019058)3.14631502
31protein localization to endoplasmic reticulum (GO:0070972)3.13083439
32antigen processing and presentation of endogenous antigen (GO:0019883)3.12603799
33desmosome organization (GO:0002934)3.12192507
34telomere maintenance via recombination (GO:0000722)3.11182696
35skin morphogenesis (GO:0043589)3.11120316
36ribosomal large subunit biogenesis (GO:0042273)3.06978693
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06934006
38cellular protein complex disassembly (GO:0043624)2.99520843
39mitotic nuclear envelope reassembly (GO:0007084)2.98154918
40nuclear envelope reassembly (GO:0031468)2.98154918
41neutrophil activation involved in immune response (GO:0002283)2.92748360
42mitotic recombination (GO:0006312)2.90541835
43DNA unwinding involved in DNA replication (GO:0006268)2.90423689
44protein localization to endosome (GO:0036010)2.87261040
45Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86872787
46protein localization to kinetochore (GO:0034501)2.85394358
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83029679
48negative regulation of glycoprotein metabolic process (GO:1903019)2.81090309
49DNA replication initiation (GO:0006270)2.79111306
50detection of bacterium (GO:0016045)2.76018375
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75759921
52amyloid precursor protein catabolic process (GO:0042987)2.73331285
53GDP-mannose metabolic process (GO:0019673)2.72791589
54protein retention in ER lumen (GO:0006621)2.71918351
55detection of other organism (GO:0098543)2.71214254
56response to peptidoglycan (GO:0032494)2.70831577
57production of molecular mediator involved in inflammatory response (GO:0002532)2.68135734
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67110861
59protein complex disassembly (GO:0043241)2.66236011
60pentose-phosphate shunt (GO:0006098)2.65856157
61immunoglobulin mediated immune response (GO:0016064)2.65775764
62IMP biosynthetic process (GO:0006188)2.65450356
63DNA replication checkpoint (GO:0000076)2.64679096
64hypotonic response (GO:0006971)2.62059670
65negative regulation of glycoprotein biosynthetic process (GO:0010561)2.61717221
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61036672
67telomere maintenance via telomere lengthening (GO:0010833)2.60893389
68cellular response to zinc ion (GO:0071294)2.59438552
69leukocyte aggregation (GO:0070486)2.58052847
70nucleoside salvage (GO:0043174)2.57805115
71mitotic nuclear envelope disassembly (GO:0007077)2.57002071
72ribonucleoprotein complex biogenesis (GO:0022613)2.56969989
73fibril organization (GO:0097435)2.55782715
74B cell mediated immunity (GO:0019724)2.50057047
75NIK/NF-kappaB signaling (GO:0038061)2.48718774
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48532846
77endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.48173107
78regulation of protein heterodimerization activity (GO:0043497)2.47393479
79response to progesterone (GO:0032570)2.47064116
80macromolecular complex disassembly (GO:0032984)2.46401463
81extracellular fibril organization (GO:0043206)2.45988510
82T cell apoptotic process (GO:0070231)2.44476091
83type I interferon signaling pathway (GO:0060337)2.43357073
84cellular response to type I interferon (GO:0071357)2.43357073
85nucleobase biosynthetic process (GO:0046112)2.43320031
86IMP metabolic process (GO:0046040)2.41740661
87translation (GO:0006412)2.41707355
88nuclear-transcribed mRNA catabolic process (GO:0000956)2.40386562
89negative regulation of cell killing (GO:0031342)2.39613078
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39613078
91response to type I interferon (GO:0034340)2.39103193
92regulation of necrotic cell death (GO:0010939)2.38526027
93mature B cell differentiation involved in immune response (GO:0002313)2.38295076
94protein localization to chromosome, centromeric region (GO:0071459)2.38131911
95glucose catabolic process (GO:0006007)2.37841088
96negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.37260555
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.36787043
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.36220045
99nuclear envelope disassembly (GO:0051081)2.35715500
100membrane disassembly (GO:0030397)2.35715500
101regulation of superoxide anion generation (GO:0032928)2.35285293
102mitotic metaphase plate congression (GO:0007080)2.33187876
103actin filament depolymerization (GO:0030042)2.32777329
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30741075
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.30374491
106mRNA catabolic process (GO:0006402)2.29841257
107response to interferon-beta (GO:0035456)2.28879158
108positive regulation of actin filament depolymerization (GO:0030836)2.28223869
109regulation of apoptotic process involved in morphogenesis (GO:1902337)2.27960105
110positive regulation of protein import into nucleus, translocation (GO:0033160)2.27742193
111lymphocyte apoptotic process (GO:0070227)2.27634740
112regulation of extracellular matrix disassembly (GO:0010715)2.26939157
113establishment of viral latency (GO:0019043)2.26571628
114protein targeting to membrane (GO:0006612)2.25621991
115negative regulation of nitric oxide biosynthetic process (GO:0045019)2.25445392
116cellular copper ion homeostasis (GO:0006878)2.25134519
117macrophage activation involved in immune response (GO:0002281)2.24290270
118RNA catabolic process (GO:0006401)2.23470357
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.22850750
120cellular response to virus (GO:0098586)2.22702336
121sequestering of actin monomers (GO:0042989)2.22634086
122antigen processing and presentation via MHC class Ib (GO:0002475)2.22034971
123DNA deamination (GO:0045006)2.21728523
124purine nucleobase biosynthetic process (GO:0009113)2.21553514
125lipoxygenase pathway (GO:0019372)2.20804571
126cellular response to arsenic-containing substance (GO:0071243)2.20162450
127negative regulation of interleukin-12 production (GO:0032695)2.19698717
128negative regulation of necroptotic process (GO:0060546)2.19038952
129regulation of water loss via skin (GO:0033561)2.17121323
130detection of external biotic stimulus (GO:0098581)2.16518838
131antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.16124913
132positive regulation of lamellipodium assembly (GO:0010592)2.16014457
133regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15967668
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.15844055
135response to host (GO:0075136)2.15844055
136response to host defenses (GO:0052200)2.15844055
137DNA replication-dependent nucleosome assembly (GO:0006335)2.15418723
138DNA replication-dependent nucleosome organization (GO:0034723)2.15418723
139establishment of chromosome localization (GO:0051303)2.14587417
140CENP-A containing nucleosome assembly (GO:0034080)2.14058294
141kinetochore organization (GO:0051383)2.14017898
142virion assembly (GO:0019068)2.13443023
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.13117853
144rRNA processing (GO:0006364)2.12913429
145regulation of SMAD protein import into nucleus (GO:0060390)2.12147510
146positive regulation of interferon-alpha production (GO:0032727)2.12029649
147regulation of podosome assembly (GO:0071801)2.11703316
148regulation of gene silencing by RNA (GO:0060966)2.11447066
149regulation of posttranscriptional gene silencing (GO:0060147)2.11447066
150regulation of gene silencing by miRNA (GO:0060964)2.11447066
151pentose metabolic process (GO:0019321)2.11161418
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.11077583
153membrane protein intracellular domain proteolysis (GO:0031293)2.10873735
154morphogenesis of an endothelium (GO:0003159)2.10294883
155endothelial tube morphogenesis (GO:0061154)2.10294883
156negative regulation of phagocytosis (GO:0050765)2.10283075
157positive regulation of macrophage differentiation (GO:0045651)2.10199167
158regulation of interferon-beta biosynthetic process (GO:0045357)2.09402380
159response to interferon-alpha (GO:0035455)2.09345302
160membrane protein ectodomain proteolysis (GO:0006509)2.09147912
161neutrophil activation (GO:0042119)2.08645546
162chromatin remodeling at centromere (GO:0031055)2.08221602
163cell cycle G1/S phase transition (GO:0044843)2.08029426
164G1/S transition of mitotic cell cycle (GO:0000082)2.08029426
165nucleotide salvage (GO:0043173)2.07797837
1663-UTR-mediated mRNA stabilization (GO:0070935)2.07480510
167ribosome biogenesis (GO:0042254)2.07448041
168cellular response to dsRNA (GO:0071359)2.07083757
169telomere maintenance (GO:0000723)2.06908624
170metaphase plate congression (GO:0051310)2.06607274
171heterochromatin organization (GO:0070828)2.06199034
172nuclear pore organization (GO:0006999)2.05949564
173modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.05754577
174modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.05754577
175positive regulation by organism of defense response of other organism involved in symbiotic interact2.05754577
176modulation by symbiont of host immune response (GO:0052553)2.05754577
177positive regulation by symbiont of host defense response (GO:0052509)2.05754577
178modulation by symbiont of host defense response (GO:0052031)2.05754577
179myeloid cell homeostasis (GO:0002262)2.05582389
180telomere organization (GO:0032200)2.04714514
181nucleobase-containing small molecule interconversion (GO:0015949)2.04440605
182respiratory burst (GO:0045730)2.03974203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93155203
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.34060336
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.18596494
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09794989
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.00752285
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.93826779
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41942597
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38489686
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26464937
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.18868856
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.15212597
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.13851847
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00679130
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98160651
15MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96141437
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89895534
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.88982763
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88360216
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.88118514
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83406561
21ZNF263_19887448_ChIP-Seq_K562_Human1.81650917
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79875844
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79185221
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74581028
25XRN2_22483619_ChIP-Seq_HELA_Human1.71205172
26MYC_22102868_ChIP-Seq_BL_Human1.69460344
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69291712
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66144358
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65481132
30AR_21909140_ChIP-Seq_LNCAP_Human1.64654943
31RACK7_27058665_Chip-Seq_MCF-7_Human1.64200475
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.60747222
33* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60724094
34LXR_22292898_ChIP-Seq_THP-1_Human1.60683280
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58891528
36SPI1_23547873_ChIP-Seq_NB4_Human1.57112806
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54464037
38ELK1_19687146_ChIP-ChIP_HELA_Human1.53265328
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52890109
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52470736
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52468333
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51018242
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50694469
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49791951
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.49584638
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47970789
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47491125
48DCP1A_22483619_ChIP-Seq_HELA_Human1.46501255
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46001377
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45415286
51VDR_23849224_ChIP-Seq_CD4+_Human1.44930824
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43047929
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42796971
54* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42331408
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42331408
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40567597
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39675989
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38951234
59TFEB_21752829_ChIP-Seq_HELA_Human1.38595105
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37838375
61VDR_21846776_ChIP-Seq_THP-1_Human1.36558693
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36035372
63TTF2_22483619_ChIP-Seq_HELA_Human1.35723456
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35564421
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32179634
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31729331
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31444823
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31278027
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28973591
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28449908
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27507230
72* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24956397
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24060878
74* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23295385
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23013181
76FOXP3_21729870_ChIP-Seq_TREG_Human1.22562577
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22236852
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22223092
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21096800
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19695753
81UTX_26944678_Chip-Seq_JUKART_Human1.19221246
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18382240
83MAF_26560356_Chip-Seq_TH2_Human1.17735029
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17219190
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.15474037
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15422946
87GABP_19822575_ChIP-Seq_HepG2_Human1.14907957
88MAF_26560356_Chip-Seq_TH1_Human1.14253936
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.14172742
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.14094010
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14065809
92MYB_26560356_Chip-Seq_TH2_Human1.12372917
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11840523
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11309511
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11240787
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10353415
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10268354
98* ELK1_22589737_ChIP-Seq_MCF10A_Human1.10180961
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09950274
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09751158
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09569737
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09391187
103SPI1_23127762_ChIP-Seq_K562_Human1.09073312
104BCOR_27268052_Chip-Seq_Bcells_Human1.08566898
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08520235
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08357380
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08163983
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07809920
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.06070187
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05178080
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05035919
112BCL6_27268052_Chip-Seq_Bcells_Human1.04706474
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04537386
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04306885
115KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04224181
116NCOR1_26117541_ChIP-Seq_K562_Human1.03647573
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03257156
118* RUNX1_22412390_ChIP-Seq_EML_Mouse1.03166588
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03115269
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02948502
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02282610
122* TCF7_22412390_ChIP-Seq_EML_Mouse1.00961806
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00926642
124VDR_24763502_ChIP-Seq_THP-1_Human1.00846443
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00058646
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00032710
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98321043
128MYB_26560356_Chip-Seq_TH1_Human0.97378912
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.97233148
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.96876935
131TRIM28_21343339_ChIP-Seq_HEK293_Human0.96012689
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95877741
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95639956
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95539164
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95052977
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95052977
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95052977
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94180451
139SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93318473
140ATF3_27146783_Chip-Seq_COLON_Human0.92882203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.05987102
2MP0003693_abnormal_embryo_hatching2.92656726
3MP0010352_gastrointestinal_tract_polyps2.65852310
4MP0004957_abnormal_blastocyst_morpholog2.33083657
5MP0003436_decreased_susceptibility_to2.29559776
6MP0005058_abnormal_lysosome_morphology2.28950056
7MP0010234_abnormal_vibrissa_follicle2.25999635
8MP0001835_abnormal_antigen_presentation2.22690534
9MP0003566_abnormal_cell_adhesion2.15939614
10MP0003806_abnormal_nucleotide_metabolis2.05854280
11MP0002796_impaired_skin_barrier2.03661389
12MP0003077_abnormal_cell_cycle1.99055863
13MP0003950_abnormal_plasma_membrane1.97483985
14MP0010094_abnormal_chromosome_stability1.95151715
15MP0009785_altered_susceptibility_to1.93034188
16MP0006054_spinal_hemorrhage1.91031201
17MP0003111_abnormal_nucleus_morphology1.90044559
18MP0005451_abnormal_body_composition1.86376395
19MP0009840_abnormal_foam_cell1.81973729
20MP0003705_abnormal_hypodermis_morpholog1.81714363
21MP0008007_abnormal_cellular_replicative1.73940007
22MP0008260_abnormal_autophagy1.73691460
23MP0005023_abnormal_wound_healing1.73673142
24MP0008057_abnormal_DNA_replication1.69768976
25MP0003941_abnormal_skin_development1.68867314
26MP0000685_abnormal_immune_system1.66208257
27MP0002148_abnormal_hypersensitivity_rea1.66090283
28MP0000490_abnormal_crypts_of1.65931444
29MP0004510_myositis1.64617184
30MP0000858_altered_metastatic_potential1.62050442
31MP0002396_abnormal_hematopoietic_system1.58353639
32MP0003075_altered_response_to1.58310509
33MP0009333_abnormal_splenocyte_physiolog1.52777611
34MP0004808_abnormal_hematopoietic_stem1.51488509
35MP0002405_respiratory_system_inflammati1.49798366
36MP0005387_immune_system_phenotype1.48831070
37MP0001790_abnormal_immune_system1.48831070
38MP0001853_heart_inflammation1.44920173
39MP0005397_hematopoietic_system_phenotyp1.44378097
40MP0001545_abnormal_hematopoietic_system1.44378097
41MP0003724_increased_susceptibility_to1.43975211
42MP0003303_peritoneal_inflammation1.43632668
43MP0002452_abnormal_antigen_presenting1.43291190
44MP0002419_abnormal_innate_immunity1.43265622
45MP0005165_increased_susceptibility_to1.42141188
46MP0005025_abnormal_response_to1.41827899
47MP0001873_stomach_inflammation1.40233073
48MP0005000_abnormal_immune_tolerance1.39554002
49MP0009278_abnormal_bone_marrow1.38380836
50MP0003448_altered_tumor_morphology1.36881223
51MP0002877_abnormal_melanocyte_morpholog1.36152898
52MP0008438_abnormal_cutaneous_collagen1.35206026
53MP0010307_abnormal_tumor_latency1.34251018
54MP0000343_altered_response_to1.32941042
55MP0001800_abnormal_humoral_immune1.31688535
56MP0010155_abnormal_intestine_physiology1.30103312
57MP0005076_abnormal_cell_differentiation1.27544782
58MP0001819_abnormal_immune_cell1.27488794
59MP0002420_abnormal_adaptive_immunity1.26424834
60MP0005257_abnormal_intraocular_pressure1.24046279
61MP0000350_abnormal_cell_proliferation1.23492727
62MP0005275_abnormal_skin_tensile1.22407996
63MP0008932_abnormal_embryonic_tissue1.20951106
64MP0001533_abnormal_skeleton_physiology1.20084672
65MP0002723_abnormal_immune_serum1.19773394
66MP0003828_pulmonary_edema1.19278234
67MP0000750_abnormal_muscle_regeneration1.19239890
68MP0003186_abnormal_redox_activity1.18651645
69MP0002398_abnormal_bone_marrow1.17063917
70MP0008469_abnormal_protein_level1.15126163
71MP0008058_abnormal_DNA_repair1.14445878
72MP0005166_decreased_susceptibility_to1.13363627
73MP0004947_skin_inflammation1.12821144
74MP0005164_abnormal_response_to1.12166877
75MP0003763_abnormal_thymus_physiology1.11581348
76MP0001730_embryonic_growth_arrest1.10634354
77MP0002722_abnormal_immune_system1.09248008
78MP0010030_abnormal_orbit_morphology1.08739851
79MP0001243_abnormal_dermal_layer1.08350985
80MP0003279_aneurysm1.08197384
81MP0006082_CNS_inflammation1.07457790
82MP0000689_abnormal_spleen_morphology1.06731786
83MP0002019_abnormal_tumor_incidence1.06104001
84MP0003567_abnormal_fetal_cardiomyocyte1.04568746
85MP0005671_abnormal_response_to1.03769119
86MP0000716_abnormal_immune_system1.03136192
87MP0001851_eye_inflammation1.03047496
88MP0001542_abnormal_bone_strength1.02631796
89MP0003786_premature_aging1.02592222
90MP0002060_abnormal_skin_morphology1.02015533
91MP0001958_emphysema1.01869488
92MP0003172_abnormal_lysosome_physiology1.00627901
93MP0003453_abnormal_keratinocyte_physiol0.99744414
94MP0002429_abnormal_blood_cell0.99515773
95MP0003656_abnormal_erythrocyte_physiolo0.98527670
96MP0001845_abnormal_inflammatory_respons0.97844676
97MP0002998_abnormal_bone_remodeling0.96632792
98MP0005464_abnormal_platelet_physiology0.95981685
99MP0000465_gastrointestinal_hemorrhage0.95833846
100MP0002086_abnormal_extraembryonic_tissu0.95167504
101MP0002933_joint_inflammation0.94418357
102MP0003123_paternal_imprinting0.93497284
103MP0005390_skeleton_phenotype0.93076611
104MP0003300_gastrointestinal_ulcer0.91693762
105MP0002332_abnormal_exercise_endurance0.91448946
106MP0000678_abnormal_parathyroid_gland0.91365637
107MP0001672_abnormal_embryogenesis/_devel0.91273316
108MP0005380_embryogenesis_phenotype0.91273316
109MP0009931_abnormal_skin_appearance0.91262038
110MP0001216_abnormal_epidermal_layer0.91050581
111MP0000313_abnormal_cell_death0.90063017
112MP0003984_embryonic_growth_retardation0.89670903
113MP0002098_abnormal_vibrissa_morphology0.89278281
114MP0010771_integument_phenotype0.89168297
115MP0002132_abnormal_respiratory_system0.87962780
116MP0002088_abnormal_embryonic_growth/wei0.87791738
117MP0001697_abnormal_embryo_size0.87148116
118MP0005083_abnormal_biliary_tract0.86932073
119MP0009764_decreased_sensitivity_to0.85933518
120MP0000516_abnormal_urinary_system0.85315844
121MP0005367_renal/urinary_system_phenotyp0.85315844
122MP0004197_abnormal_fetal_growth/weight/0.85186827
123MP0002006_tumorigenesis0.84091857
124MP0003045_fibrosis0.84064932
125MP0000703_abnormal_thymus_morphology0.81637548
126MP0005330_cardiomyopathy0.81098394
127MP0003795_abnormal_bone_structure0.80440366
128MP0002080_prenatal_lethality0.79830058
129MP0000003_abnormal_adipose_tissue0.79659337
130MP0002166_altered_tumor_susceptibility0.78924456
131MP0001879_abnormal_lymphatic_vessel0.78894585
132MP0004272_abnormal_basement_membrane0.78663259
133MP0003091_abnormal_cell_migration0.78611816
134MP0005501_abnormal_skin_physiology0.76464026
135MP0004233_abnormal_muscle_weight0.73734968
136MP0000749_muscle_degeneration0.73254203

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.77715307
2Recurrent abscess formation (HP:0002722)3.64770060
3Eczematoid dermatitis (HP:0000976)3.50034911
4Reduced subcutaneous adipose tissue (HP:0003758)3.20777346
5Abnormality of glycolipid metabolism (HP:0010969)3.11250880
6Abnormality of liposaccharide metabolism (HP:0010968)3.11250880
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.11250880
8Amyloidosis (HP:0011034)2.99938053
9Abnormality of cells of the erythroid lineage (HP:0012130)2.93595355
10Recurrent bacterial skin infections (HP:0005406)2.92021350
11Fatigue (HP:0012378)2.84194300
12Myositis (HP:0100614)2.74486186
13Abnormal number of erythroid precursors (HP:0012131)2.72110626
14Thrombocytosis (HP:0001894)2.70933953
15Alopecia of scalp (HP:0002293)2.68184879
16Selective tooth agenesis (HP:0001592)2.59298148
17Increased IgE level (HP:0003212)2.56235503
18Trismus (HP:0000211)2.52543168
19Abnormality of macrophages (HP:0004311)2.52403984
2011 pairs of ribs (HP:0000878)2.51274242
21Glucose intolerance (HP:0000833)2.48579045
22Axonal loss (HP:0003447)2.47147992
23Short nail (HP:0001799)2.46160878
24Elevated erythrocyte sedimentation rate (HP:0003565)2.40703254
25Cervical subluxation (HP:0003308)2.40488606
26Increased connective tissue (HP:0009025)2.40375937
27Thick nail (HP:0001805)2.39878206
28Distal lower limb amyotrophy (HP:0008944)2.36641390
29Abnormality of the anterior horn cell (HP:0006802)2.36265866
30Degeneration of anterior horn cells (HP:0002398)2.36265866
31Hypertensive crisis (HP:0100735)2.35247849
32Agnosia (HP:0010524)2.31874000
33Dysostosis multiplex (HP:0000943)2.30915447
34Mediastinal lymphadenopathy (HP:0100721)2.30784194
35Hepatosplenomegaly (HP:0001433)2.27297893
36Entropion (HP:0000621)2.24686739
37Aplastic anemia (HP:0001915)2.23559276
38Interstitial pulmonary disease (HP:0006530)2.22665842
39Recurrent fungal infections (HP:0002841)2.22037489
40Vertebral compression fractures (HP:0002953)2.21632053
41Hypokinesia (HP:0002375)2.19657810
42Pallor (HP:0000980)2.19065769
43Osteolytic defects of the hand bones (HP:0009699)2.14549998
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.14549998
45Protrusio acetabuli (HP:0003179)2.12121825
46Orchitis (HP:0100796)2.11564570
47Colon cancer (HP:0003003)2.10965602
48Congenital ichthyosiform erythroderma (HP:0007431)2.09475877
49Syringomyelia (HP:0003396)2.09260493
50Spinal cord lesions (HP:0100561)2.09260493
51Vascular calcification (HP:0004934)2.09176318
52Fragile skin (HP:0001030)2.07761315
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05820812
54Cellulitis (HP:0100658)2.03812236
55Birth length less than 3rd percentile (HP:0003561)2.03799543
56Vacuolated lymphocytes (HP:0001922)2.03724299
57Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03299779
58Vertebral hypoplasia (HP:0008417)2.03299779
59Chromsome breakage (HP:0040012)2.02573544
60Palmoplantar hyperkeratosis (HP:0000972)2.01575421
61Abnormal blistering of the skin (HP:0008066)2.01380774
62Progressive neurologic deterioration (HP:0002344)2.00885828
63Cardiovascular calcification (HP:0011915)2.00853606
64Pustule (HP:0200039)2.00362522
65Rough bone trabeculation (HP:0100670)1.97752564
66Spondylolisthesis (HP:0003302)1.96756222
67Abnormality of nail color (HP:0100643)1.96634979
68Broad face (HP:0000283)1.95787474
69Poor head control (HP:0002421)1.94835137
70Recurrent viral infections (HP:0004429)1.92248684
71Absent thumb (HP:0009777)1.91795094
72Cholecystitis (HP:0001082)1.91617813
73Abnormal gallbladder physiology (HP:0012438)1.91617813
74Abnormality of the calcaneus (HP:0008364)1.90284512
75Abnormality of the distal phalanges of the toes (HP:0010182)1.90190023
76Ankle contracture (HP:0006466)1.89634638
77Metaphyseal cupping (HP:0003021)1.89550829
78Orthostatic hypotension (HP:0001278)1.89518769
79Elbow flexion contracture (HP:0002987)1.88787025
80Prolonged neonatal jaundice (HP:0006579)1.88111099
81Achilles tendon contracture (HP:0001771)1.86956232
82Recurrent gram-negative bacterial infections (HP:0005420)1.86405526
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85873939
84Missing ribs (HP:0000921)1.85527390
85Loss of speech (HP:0002371)1.85523165
86Impaired platelet aggregation (HP:0003540)1.85305651
87Abnormal platelet function (HP:0011869)1.85305651
88Erythema (HP:0010783)1.85270742
89Obstructive lung disease (HP:0006536)1.85109950
90Chronic obstructive pulmonary disease (HP:0006510)1.85109950
91IgM deficiency (HP:0002850)1.83692411
92Ragged-red muscle fibers (HP:0003200)1.83457992
93Atrophic scars (HP:0001075)1.83370241
94Right ventricular cardiomyopathy (HP:0011663)1.82989454
95Glossoptosis (HP:0000162)1.82455140
96Increased serum ferritin (HP:0003281)1.82131165
97Onycholysis (HP:0001806)1.81520177
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81245335
99Abnormality of polysaccharide metabolism (HP:0011012)1.81245335
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81245335
101Generalized amyotrophy (HP:0003700)1.81103678
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80295591
103Skin ulcer (HP:0200042)1.80109533
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.79006612
105Polygenic inheritance (HP:0010982)1.77461499
106Abnormality of T cell physiology (HP:0011840)1.76758335
107Acanthosis nigricans (HP:0000956)1.75410843
108Abnormal hemoglobin (HP:0011902)1.74154018
109Myocardial infarction (HP:0001658)1.73944993
110Hypergammaglobulinemia (HP:0010702)1.73402388
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.72999146
112Deviation of the thumb (HP:0009603)1.72574577
113Myelodysplasia (HP:0002863)1.72436426
114Urinary glycosaminoglycan excretion (HP:0003541)1.72184634
115Mucopolysacchariduria (HP:0008155)1.72184634
116Macrocytic anemia (HP:0001972)1.72147258
117Palmar hyperkeratosis (HP:0010765)1.72091009
118Increased density of long bones (HP:0006392)1.70783095
119Hypertriglyceridemia (HP:0002155)1.70762151
120Increased cerebral lipofuscin (HP:0011813)1.70710752
121Sparse eyelashes (HP:0000653)1.70037721
122Muscle fiber atrophy (HP:0100295)1.69990844
123Blepharitis (HP:0000498)1.69631236
124Difficulty climbing stairs (HP:0003551)1.68544646
125Recurrent skin infections (HP:0001581)1.66394414
126Joint stiffness (HP:0001387)1.65399229
127Stomatitis (HP:0010280)1.64583946
128Milia (HP:0001056)1.64343245
129Breast hypoplasia (HP:0003187)1.64152256
130Oral leukoplakia (HP:0002745)1.63786778
131Recurrent lower respiratory tract infections (HP:0002783)1.63650800
132Beaking of vertebral bodies (HP:0004568)1.63377746
133Fragile nails (HP:0001808)1.62978667
134Gingivitis (HP:0000230)1.62152978
135Multiple enchondromatosis (HP:0005701)1.61168180
136Ulnar deviation of the wrist (HP:0003049)1.60411997
137Tracheoesophageal fistula (HP:0002575)1.58913251
138Cleft eyelid (HP:0000625)1.56586613
139Petechiae (HP:0000967)1.56151217
140Premature rupture of membranes (HP:0001788)1.54623422
141Abnormal trabecular bone morphology (HP:0100671)1.54188213
142Mesomelia (HP:0003027)1.53347333
143Cheilitis (HP:0100825)1.52952823
144Urticaria (HP:0001025)1.51200925
145Carpal bone hypoplasia (HP:0001498)1.50779291
146Optic nerve coloboma (HP:0000588)1.50223753
147Retrobulbar optic neuritis (HP:0100654)1.49931203
148Optic neuritis (HP:0100653)1.49931203
149Patellar aplasia (HP:0006443)1.49372536
150Osteomyelitis (HP:0002754)1.48694878
151Lymphoma (HP:0002665)1.48164947
152Nail dystrophy (HP:0008404)1.47946865
153Stillbirth (HP:0003826)1.47594345
154Meckel diverticulum (HP:0002245)1.47565554
155Plantar hyperkeratosis (HP:0007556)1.47170397
156Distal lower limb muscle weakness (HP:0009053)1.45833050
157Radial bowing (HP:0002986)1.45805086
158Spinal muscular atrophy (HP:0007269)1.44819409
159Congenital, generalized hypertrichosis (HP:0004540)1.44538819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.26227088
2MST1R2.83892198
3VRK22.77673295
4WEE12.44660719
5TESK12.22424738
6PIM22.17859351
7RPS6KA42.08735057
8ARAF2.05667526
9PRPF4B2.05239792
10EPHA22.05164193
11SMG12.04415715
12BUB12.01995694
13STK102.01957069
14MAP3K32.00663925
15CDC71.96880681
16MAP4K11.87261520
17MAP2K31.78391398
18LRRK21.77552747
19ERN11.75281072
20RPS6KB21.71971658
21TRPM71.67575594
22LMTK21.62203032
23TGFBR11.59175270
24SIK31.57333302
25TESK21.57293179
26MOS1.53607687
27BRSK21.52465109
28TAOK21.49269528
29PAK41.46452285
30MAP3K121.45817177
31IRAK41.44384711
32BLK1.43095656
33NEK21.42704849
34EPHB11.40959533
35MST41.36972118
36EIF2AK11.32827912
37ACVR1B1.31306485
38ERBB31.29513630
39TTN1.29423638
40PKN21.29394502
41NEK91.27971763
42KIT1.27694470
43TBK11.26709345
44PIM11.25640237
45MAP3K81.24074762
46CDK71.23582423
47MAP3K111.20879202
48ABL21.19688145
49EEF2K1.18360008
50JAK31.16708148
51AURKB1.16220543
52SIK11.14519073
53TYK21.14071815
54FLT31.12182562
55ZAP701.11448227
56MAP3K141.11200732
57KDR1.09984850
58STK241.07818188
59PASK1.06137824
60IKBKB1.03232697
61MAPKAPK31.02399675
62MYLK1.02142162
63BTK1.01304511
64STK41.00688480
65RIPK41.00198161
66PLK10.98433844
67PBK0.97844296
68CDK60.95189605
69DAPK10.94886404
70TGFBR20.92514020
71LIMK10.91828118
72TEC0.91679388
73CSK0.90427823
74CDK120.90038590
75MAP3K10.89649907
76ILK0.88645684
77MATK0.88216770
78NEK10.87798085
79EIF2AK30.87545771
80MET0.87124007
81SCYL20.87088579
82ATR0.86653986
83ZAK0.84801678
84HIPK20.84184389
85PLK40.83603289
86IRAK30.82508332
87TRIB30.81411791
88TTK0.81364162
89ICK0.81161472
90STK160.81119057
91GRK60.76170734
92PRKG20.74414854
93CLK10.73413756
94MAPK110.72367111
95BMPR20.72360569
96CSF1R0.71618521
97CHUK0.71274975
98CDK40.65435460
99PTK60.65169975
100MKNK10.65168278
101MAPKAPK20.65057191
102TSSK60.62210895
103IKBKE0.62153961
104VRK10.61850206
105MAP3K130.61135996
106MAP3K60.60484415
107PRKD20.59018509
108BRAF0.58680217
109STK30.58226986
110PTK2B0.56955677
111TAOK10.56132669
112BMX0.55948608
113MAP3K20.55365469
114RPS6KA60.55072790
115MAP2K60.54005238
116BRSK10.52187389
117EIF2AK20.51847289
118PAK10.51026585
119MAP3K100.50896837
120GRK70.49574543
121PDK20.48977797
122MAP3K50.48822320
123AURKA0.48185988
124RPS6KL10.47332038
125RPS6KC10.47332038
126CDK80.47127847
127PLK30.47005480
128PDPK10.45784000
129PRKCI0.45289734
130JAK10.45255121
131IRAK20.45194124
132PTK20.43364027
133ALK0.43300247
134HCK0.42395324
135CSNK2A10.42395292
136EPHB20.42099367
137MAP2K20.41122962
138MARK30.38822661
139CDC42BPA0.38556872
140RIPK10.38060545
141STK380.37378435
142TXK0.37022943
143GSK3A0.35860041
144RAF10.35517967
145ERBB40.34912533
146BCKDK0.34651119
147MELK0.33391684
148KSR20.31543580

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.63929897
2Ribosome_Homo sapiens_hsa030103.39820620
3Mismatch repair_Homo sapiens_hsa034302.98804624
4Proteasome_Homo sapiens_hsa030502.39426914
5Base excision repair_Homo sapiens_hsa034102.23261479
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03730335
7Homologous recombination_Homo sapiens_hsa034401.98835823
8Nucleotide excision repair_Homo sapiens_hsa034201.84321705
9Cell cycle_Homo sapiens_hsa041101.83461441
10Spliceosome_Homo sapiens_hsa030401.83407342
11RNA polymerase_Homo sapiens_hsa030201.81448868
12RNA transport_Homo sapiens_hsa030131.77957396
13Leishmaniasis_Homo sapiens_hsa051401.77529813
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74280898
15Sulfur relay system_Homo sapiens_hsa041221.69698402
16Sulfur metabolism_Homo sapiens_hsa009201.68308925
17Antigen processing and presentation_Homo sapiens_hsa046121.62614457
18Legionellosis_Homo sapiens_hsa051341.61001018
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59839913
20p53 signaling pathway_Homo sapiens_hsa041151.59067119
21Pyrimidine metabolism_Homo sapiens_hsa002401.51796226
22Fructose and mannose metabolism_Homo sapiens_hsa000511.51062737
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46779316
24One carbon pool by folate_Homo sapiens_hsa006701.46161107
25Vibrio cholerae infection_Homo sapiens_hsa051101.40230981
26Shigellosis_Homo sapiens_hsa051311.38100894
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.32263904
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29922970
29Herpes simplex infection_Homo sapiens_hsa051681.28345313
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.24472745
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23867318
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23237596
33Apoptosis_Homo sapiens_hsa042101.20456063
34Epstein-Barr virus infection_Homo sapiens_hsa051691.14784463
35Fanconi anemia pathway_Homo sapiens_hsa034601.13962563
36N-Glycan biosynthesis_Homo sapiens_hsa005101.13932201
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13585741
38Non-homologous end-joining_Homo sapiens_hsa034501.12580267
39Measles_Homo sapiens_hsa051621.12332467
40Autoimmune thyroid disease_Homo sapiens_hsa053201.11637155
41RNA degradation_Homo sapiens_hsa030181.11466586
42Small cell lung cancer_Homo sapiens_hsa052221.08755209
43Toxoplasmosis_Homo sapiens_hsa051451.07902356
44Viral myocarditis_Homo sapiens_hsa054161.07445407
45Malaria_Homo sapiens_hsa051441.06124093
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04841757
47Pertussis_Homo sapiens_hsa051331.03922749
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03529214
49Adherens junction_Homo sapiens_hsa045201.02034393
50Folate biosynthesis_Homo sapiens_hsa007901.01971649
51HTLV-I infection_Homo sapiens_hsa051661.00195409
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.99936695
53Hematopoietic cell lineage_Homo sapiens_hsa046400.99840735
54Influenza A_Homo sapiens_hsa051640.97588781
55Rheumatoid arthritis_Homo sapiens_hsa053230.97317392
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96315540
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95964788
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95962856
59Endocytosis_Homo sapiens_hsa041440.94751572
60Graft-versus-host disease_Homo sapiens_hsa053320.94655519
61Asthma_Homo sapiens_hsa053100.93874696
62Osteoclast differentiation_Homo sapiens_hsa043800.93739248
63Hepatitis B_Homo sapiens_hsa051610.91229232
64Primary immunodeficiency_Homo sapiens_hsa053400.91130118
65Viral carcinogenesis_Homo sapiens_hsa052030.90037185
66Non-small cell lung cancer_Homo sapiens_hsa052230.89234192
67Tuberculosis_Homo sapiens_hsa051520.87948767
68Salmonella infection_Homo sapiens_hsa051320.86871731
69Bladder cancer_Homo sapiens_hsa052190.86220101
70TNF signaling pathway_Homo sapiens_hsa046680.85992692
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84292285
72TGF-beta signaling pathway_Homo sapiens_hsa043500.83110622
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.80309897
74Allograft rejection_Homo sapiens_hsa053300.80287011
75Type I diabetes mellitus_Homo sapiens_hsa049400.80086954
76MicroRNAs in cancer_Homo sapiens_hsa052060.78646147
77Other glycan degradation_Homo sapiens_hsa005110.78070035
78Proteoglycans in cancer_Homo sapiens_hsa052050.77584979
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77176364
80ECM-receptor interaction_Homo sapiens_hsa045120.76046878
81VEGF signaling pathway_Homo sapiens_hsa043700.75364078
82Thyroid cancer_Homo sapiens_hsa052160.75220513
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.74999368
84Basal transcription factors_Homo sapiens_hsa030220.74674522
85Chronic myeloid leukemia_Homo sapiens_hsa052200.74195003
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73560726
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72165665
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.71791417
89Fatty acid elongation_Homo sapiens_hsa000620.71295075
90Staphylococcus aureus infection_Homo sapiens_hsa051500.71156572
91B cell receptor signaling pathway_Homo sapiens_hsa046620.70367816
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68414285
93mRNA surveillance pathway_Homo sapiens_hsa030150.67795426
94HIF-1 signaling pathway_Homo sapiens_hsa040660.67413438
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.66152930
96Focal adhesion_Homo sapiens_hsa045100.65999635
97Glutathione metabolism_Homo sapiens_hsa004800.65619765
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65569467
99Lysosome_Homo sapiens_hsa041420.64726067
100Galactose metabolism_Homo sapiens_hsa000520.64486129
101Acute myeloid leukemia_Homo sapiens_hsa052210.63799841
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63024217
103Hippo signaling pathway_Homo sapiens_hsa043900.62414745
104Phagosome_Homo sapiens_hsa041450.61400262
105Protein export_Homo sapiens_hsa030600.60179058
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59895215
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59786554
108Sphingolipid metabolism_Homo sapiens_hsa006000.59664577
109African trypanosomiasis_Homo sapiens_hsa051430.58791963
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58641203
111T cell receptor signaling pathway_Homo sapiens_hsa046600.58421989
112Notch signaling pathway_Homo sapiens_hsa043300.57774646
113Purine metabolism_Homo sapiens_hsa002300.56787289
114Biosynthesis of amino acids_Homo sapiens_hsa012300.56428251
115Platelet activation_Homo sapiens_hsa046110.55043040
116Carbon metabolism_Homo sapiens_hsa012000.54947748
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53291283
118Renal cell carcinoma_Homo sapiens_hsa052110.52891693
119Amoebiasis_Homo sapiens_hsa051460.52781717
120Pancreatic cancer_Homo sapiens_hsa052120.50876878
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50849752
122Pathways in cancer_Homo sapiens_hsa052000.50578969
123Hepatitis C_Homo sapiens_hsa051600.49355309
124Pentose phosphate pathway_Homo sapiens_hsa000300.43948127
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43822641
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43218492
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42398113
128Arachidonic acid metabolism_Homo sapiens_hsa005900.41869151

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