PLPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)6.15931681
2lymph vessel development (GO:0001945)5.41516625
3lymphangiogenesis (GO:0001946)5.30331786
4NADH metabolic process (GO:0006734)5.14456620
5chondrocyte proliferation (GO:0035988)4.91511865
6endothelial cell morphogenesis (GO:0001886)4.69301198
7wound healing, spreading of epidermal cells (GO:0035313)4.67403073
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.55791127
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.46943404
10glomerular basement membrane development (GO:0032836)4.45950576
11glomerular visceral epithelial cell development (GO:0072015)4.43283534
12basement membrane organization (GO:0071711)4.30376996
13triglyceride catabolic process (GO:0019433)4.21372655
14endothelium development (GO:0003158)4.18172687
15collagen fibril organization (GO:0030199)4.11967439
16cell adhesion mediated by integrin (GO:0033627)4.05379901
17regulation of endothelial cell differentiation (GO:0045601)4.04665473
18vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.99723783
19glomerular epithelial cell development (GO:0072310)3.85273923
20plasma membrane repair (GO:0001778)3.80643137
21neutral lipid catabolic process (GO:0046461)3.80043649
22acylglycerol catabolic process (GO:0046464)3.80043649
23cell migration involved in sprouting angiogenesis (GO:0002042)3.79766418
24neuron projection extension involved in neuron projection guidance (GO:1902284)3.78305014
25axon extension involved in axon guidance (GO:0048846)3.78305014
26regulation of integrin-mediated signaling pathway (GO:2001044)3.77510914
27regulation of tight junction assembly (GO:2000810)3.77281207
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62217453
29wound healing, spreading of cells (GO:0044319)3.61962015
30blood vessel endothelial cell migration (GO:0043534)3.58055398
31cell migration involved in heart development (GO:0060973)3.57039651
32protein heterotrimerization (GO:0070208)3.55922030
33biotin metabolic process (GO:0006768)3.55420781
34morphogenesis of an endothelium (GO:0003159)3.54812722
35endothelial tube morphogenesis (GO:0061154)3.54812722
36sequestering of extracellular ligand from receptor (GO:0035581)3.54340305
37peptidyl-proline hydroxylation (GO:0019511)3.49675789
38blood vessel maturation (GO:0001955)3.49349399
39endothelial cell proliferation (GO:0001935)3.49181986
40protein targeting to plasma membrane (GO:0072661)3.46595481
41renal filtration (GO:0097205)3.46205451
42extracellular fibril organization (GO:0043206)3.43840254
43sprouting angiogenesis (GO:0002040)3.41834953
44cGMP-mediated signaling (GO:0019934)3.33760592
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32597996
46adhesion of symbiont to host (GO:0044406)3.32406404
47low-density lipoprotein particle clearance (GO:0034383)3.31627832
48positive regulation of vasculogenesis (GO:2001214)3.31442160
49glomerular filtration (GO:0003094)3.24999912
50endocrine hormone secretion (GO:0060986)3.22228904
51surfactant homeostasis (GO:0043129)3.21978212
52negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.19969772
53endodermal cell differentiation (GO:0035987)3.19114040
54substrate-dependent cell migration (GO:0006929)3.17837989
55positive regulation of endothelial cell migration (GO:0010595)3.17033069
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16439285
57endothelial cell differentiation (GO:0045446)3.14874318
58ethanol oxidation (GO:0006069)3.13713485
59regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.13694663
60regulation of sequestering of triglyceride (GO:0010889)3.12889210
61positive regulation of endothelial cell differentiation (GO:0045603)3.11634535
62cellular response to interferon-alpha (GO:0035457)3.10362373
63positive regulation of endothelial cell apoptotic process (GO:2000353)3.10028095
64negative regulation of blood vessel endothelial cell migration (GO:0043537)3.07400822
65regulation of metalloenzyme activity (GO:0048552)3.03584702
66extracellular matrix assembly (GO:0085029)3.03295139
67epithelial cell-cell adhesion (GO:0090136)2.94884787
68protein hydroxylation (GO:0018126)2.93292800
69ganglion development (GO:0061548)2.92475411
70regulation of vasculogenesis (GO:2001212)2.90216976
71negative regulation of smooth muscle cell migration (GO:0014912)2.89695574
72substrate adhesion-dependent cell spreading (GO:0034446)2.89478689
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86737319
74regulation of lipoprotein metabolic process (GO:0050746)2.86117444
75short-chain fatty acid metabolic process (GO:0046459)2.86045588
76peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.84166446
77apoptotic cell clearance (GO:0043277)2.84003326
78atrioventricular valve morphogenesis (GO:0003181)2.83932412
79lung lobe morphogenesis (GO:0060463)2.80464406
80alpha-linolenic acid metabolic process (GO:0036109)2.79524477
81alditol metabolic process (GO:0019400)2.79512786
82fatty acid beta-oxidation (GO:0006635)2.79051237
83fructose metabolic process (GO:0006000)2.78447827
84fatty acid transmembrane transport (GO:1902001)2.77333646
85type B pancreatic cell proliferation (GO:0044342)2.77295971
86carnitine shuttle (GO:0006853)2.76889323
87regulation of receptor binding (GO:1900120)2.76725857
88positive regulation of epithelial cell migration (GO:0010634)2.76207599
89glycerolipid catabolic process (GO:0046503)2.73874667
90protein localization to cell surface (GO:0034394)2.73528649
91fibril organization (GO:0097435)2.73351822
92positive regulation of collagen biosynthetic process (GO:0032967)2.73309570
93blood vessel remodeling (GO:0001974)2.72428336
94positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.72337428
95collagen metabolic process (GO:0032963)2.72159157
96artery development (GO:0060840)2.70543812
97desmosome organization (GO:0002934)2.69842246
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69428911
99fatty acid catabolic process (GO:0009062)2.68916524
100multicellular organismal macromolecule metabolic process (GO:0044259)2.68566994
101regulation of macrophage chemotaxis (GO:0010758)2.66506683
102keratan sulfate catabolic process (GO:0042340)2.66137154
103endothelial cell migration (GO:0043542)2.64837993
104endothelial cell chemotaxis (GO:0035767)2.64810021
105lung vasculature development (GO:0060426)2.63371201
106heart trabecula formation (GO:0060347)2.62862682
107regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.62034315
108protein retention in ER lumen (GO:0006621)2.61910234
109complement activation, classical pathway (GO:0006958)2.61578349
110negative regulation of platelet activation (GO:0010544)2.61344873
111adhesion of symbiont to host cell (GO:0044650)2.61119684
112virion attachment to host cell (GO:0019062)2.61119684
113positive regulation of collagen metabolic process (GO:0010714)2.58919987
114regulation of endothelial cell migration (GO:0010594)2.58856669
115nitric oxide biosynthetic process (GO:0006809)2.58840595
116collagen catabolic process (GO:0030574)2.56373725
117primary alcohol metabolic process (GO:0034308)2.55872928
118multicellular organismal metabolic process (GO:0044236)2.55396689
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54842045
120smooth muscle tissue development (GO:0048745)2.54206170
121response to dietary excess (GO:0002021)2.54168987
122regulation of blood vessel endothelial cell migration (GO:0043535)2.54014319
123multicellular organismal catabolic process (GO:0044243)2.53388195
124regulation of plasminogen activation (GO:0010755)2.53336788
125skin morphogenesis (GO:0043589)2.53008532
126extracellular matrix disassembly (GO:0022617)2.52941721
127negative regulation of endothelial cell migration (GO:0010596)2.51893886
128angiotensin maturation (GO:0002003)2.51064174
129negative regulation of endothelial cell proliferation (GO:0001937)2.50660205
130positive regulation of extracellular matrix organization (GO:1903055)2.50218205
131regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50118937
132fatty acid oxidation (GO:0019395)2.49471161
133acylglycerol homeostasis (GO:0055090)2.49173502
134triglyceride homeostasis (GO:0070328)2.49173502
135cellular response to lithium ion (GO:0071285)2.47443743
136positive regulation of epithelial to mesenchymal transition (GO:0010718)2.47348711
137regulation of glomerular filtration (GO:0003093)2.47190792
138glycerol metabolic process (GO:0006071)2.46945769
139transcytosis (GO:0045056)2.46476604
140actin filament depolymerization (GO:0030042)2.46437710
141extracellular matrix organization (GO:0030198)2.46404746
142venous blood vessel morphogenesis (GO:0048845)2.46252693
143extracellular structure organization (GO:0043062)2.45843879
144monocarboxylic acid catabolic process (GO:0072329)2.44872643
145ethanol metabolic process (GO:0006067)2.44871865
146very-low-density lipoprotein particle assembly (GO:0034379)2.43930104
147fatty acid homeostasis (GO:0055089)2.43556314
148lipid oxidation (GO:0034440)2.43217364
149complement activation (GO:0006956)2.43134532
150positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.43014934
151regulation of mononuclear cell migration (GO:0071675)2.42934382
152diacylglycerol metabolic process (GO:0046339)2.40599947
153triglyceride biosynthetic process (GO:0019432)2.40509097
154oxaloacetate metabolic process (GO:0006107)2.38597215
155branching involved in prostate gland morphogenesis (GO:0060442)2.38372674
156tricarboxylic acid metabolic process (GO:0072350)2.34812262
157complement activation, alternative pathway (GO:0006957)2.33830217
158acylglycerol biosynthetic process (GO:0046463)2.32791277
159neutral lipid biosynthetic process (GO:0046460)2.32791277
160negative regulation of protein localization to cell surface (GO:2000009)2.31990333
161prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.30786077
162phenol-containing compound catabolic process (GO:0019336)2.29641837
1634-hydroxyproline metabolic process (GO:0019471)2.25668772
164barbed-end actin filament capping (GO:0051016)2.25239811
165polyol transport (GO:0015791)2.25091917
166positive regulation of lipoprotein lipase activity (GO:0051006)2.24301674
167positive regulation of triglyceride lipase activity (GO:0061365)2.24301674
168cellular response to cadmium ion (GO:0071276)2.22921738
169bile acid metabolic process (GO:0008206)2.22858595
170negative regulation of catenin import into nucleus (GO:0035414)2.21999254
171creatine metabolic process (GO:0006600)2.21778520
172epoxygenase P450 pathway (GO:0019373)2.21753910
173positive regulation of astrocyte differentiation (GO:0048711)2.21184149
174triglyceride metabolic process (GO:0006641)2.20372240
175L-serine transport (GO:0015825)2.20010551
176positive regulation of glycolytic process (GO:0045821)2.17524379
177ovulation from ovarian follicle (GO:0001542)2.16614525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.47848859
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.67369790
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.35413930
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.56233599
5CLOCK_20551151_ChIP-Seq_293T_Human3.49859516
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.10192748
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00991699
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.93319836
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.90096663
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77371873
11CJUN_26792858_Chip-Seq_BT549_Human2.65336659
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.55412882
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.55304163
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47212181
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.45625416
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40836297
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.32093354
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.25078411
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16019580
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.14896456
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12551754
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.08467808
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.05796011
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05340845
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.03852564
26PIAS1_25552417_ChIP-Seq_VCAP_Human2.02153051
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.02140846
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.01282162
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.00136912
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96167986
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87889741
32SOX2_20726797_ChIP-Seq_SW620_Human1.83841343
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81303048
34JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79234708
35JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73848593
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73101992
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73101992
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72033997
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69936744
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63617910
41BRD4_25478319_ChIP-Seq_HGPS_Human1.60927085
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.60658658
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58833142
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58433088
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58433088
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56420103
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52917240
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50036280
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47508947
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46321109
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42869475
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.40156357
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.40156357
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35969589
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33966043
56ZNF263_19887448_ChIP-Seq_K562_Human1.27520854
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.26425576
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26074427
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25899404
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25884060
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25183262
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24793876
63ATF3_27146783_Chip-Seq_COLON_Human1.23707625
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20906103
65TP53_18474530_ChIP-ChIP_U2OS_Human1.20754574
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20343786
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18736069
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.14678641
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13977732
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13971813
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11872886
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11598282
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10877431
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10256364
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10256364
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10256364
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09865996
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08506925
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08408036
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.07663052
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07562141
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07076226
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06949274
84ZNF274_21170338_ChIP-Seq_K562_Hela1.06292390
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05392790
86SA1_22415368_ChIP-Seq_MEFs_Mouse1.04029870
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03720669
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03142244
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.02701755
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.02590925
91AR_21909140_ChIP-Seq_LNCAP_Human1.00511953
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99189623
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98998815
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98864067
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98235030
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97886786
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97075248
98CTCF_27219007_Chip-Seq_Bcells_Human0.95994158
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95706458
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94732815
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94539274
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.93612568
103UBF1/2_26484160_Chip-Seq_HMECs_Human0.93106335
104EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92920660
105CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92609507
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92211639
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.90516568
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.89561274
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88625727
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88454433
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88427742
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88161530
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.87988267
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86542824
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.86207954
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85708942
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85698419
118RACK7_27058665_Chip-Seq_MCF-7_Human0.85427911
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85425090
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85368085
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84788738
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.84763154
123TP63_23658742_ChIP-Seq_EP156T_Human0.84268787
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83917667
125BCAT_22108803_ChIP-Seq_LS180_Human0.83736742
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83510440
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83402757
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82421581
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81464679
130EOMES_21245162_ChIP-Seq_HESCs_Human0.80428182
131LXR_22292898_ChIP-Seq_THP-1_Human0.80140205
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80000908
133TP53_22127205_ChIP-Seq_IMR90_Human0.79893454
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78291720
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77764282
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75036972
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74744403
138GATA4_25053715_ChIP-Seq_YYC3_Human0.74595096
139NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74455087
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74354780
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73977602
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73977602
143KLF5_25053715_ChIP-Seq_YYC3_Human0.73353718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.61485329
2MP0010368_abnormal_lymphatic_system4.81214951
3MP0004272_abnormal_basement_membrane4.46330473
4MP0005503_abnormal_tendon_morphology4.12689947
5MP0005275_abnormal_skin_tensile3.96856408
6MP0001879_abnormal_lymphatic_vessel3.93187226
7MP0003279_aneurysm3.72986087
8MP0003705_abnormal_hypodermis_morpholog3.44155975
9MP0006054_spinal_hemorrhage2.93588706
10MP0005666_abnormal_adipose_tissue2.60955706
11MP0004084_abnormal_cardiac_muscle2.58031476
12MP0005360_urolithiasis2.56261088
13MP0000013_abnormal_adipose_tissue2.56131097
14MP0005623_abnormal_meninges_morphology2.55896317
15MP0001958_emphysema2.55462974
16MP0003011_delayed_dark_adaptation2.50302224
17MP0002876_abnormal_thyroid_physiology2.32091761
18MP0002295_abnormal_pulmonary_circulatio2.29204124
19MP0003566_abnormal_cell_adhesion2.28510776
20MP0010234_abnormal_vibrissa_follicle2.23929508
21MP0005375_adipose_tissue_phenotype2.00209913
22MP0002971_abnormal_brown_adipose1.97769417
23MP0005167_abnormal_blood-brain_barrier1.93761172
24MP0009384_cardiac_valve_regurgitation1.88413559
25MP0001542_abnormal_bone_strength1.84083516
26MP0000749_muscle_degeneration1.77407496
27MP0000751_myopathy1.73934634
28MP0000750_abnormal_muscle_regeneration1.73894423
29MP0005023_abnormal_wound_healing1.71338741
30MP0003724_increased_susceptibility_to1.70702881
31MP0000767_abnormal_smooth_muscle1.69982016
32MP0003868_abnormal_feces_composition1.68856734
33MP0008004_abnormal_stomach_pH1.66249886
34MP0003091_abnormal_cell_migration1.64371493
35MP0005508_abnormal_skeleton_morphology1.63447534
36MP0003828_pulmonary_edema1.62182538
37MP0006138_congestive_heart_failure1.60725725
38MP0008775_abnormal_heart_ventricle1.56830522
39MP0004130_abnormal_muscle_cell1.55468877
40MP0004145_abnormal_muscle_electrophysio1.55120080
41MP0010329_abnormal_lipoprotein_level1.53848393
42MP0005365_abnormal_bile_salt1.52073442
43MP0004036_abnormal_muscle_relaxation1.49494659
44MP0010030_abnormal_orbit_morphology1.46371617
45MP0000343_altered_response_to1.39432214
46MP0005595_abnormal_vascular_smooth1.38990296
47MP0005085_abnormal_gallbladder_physiolo1.35261355
48MP0003941_abnormal_skin_development1.29970431
49MP0003959_abnormal_lean_body1.29819896
50MP0002139_abnormal_hepatobiliary_system1.27000968
51MP0002108_abnormal_muscle_morphology1.25441500
52MP0009840_abnormal_foam_cell1.25414262
53MP0004484_altered_response_of1.24475783
54MP0005620_abnormal_muscle_contractility1.22109284
55MP0005164_abnormal_response_to1.21691481
56MP0002972_abnormal_cardiac_muscle1.19968996
57MP0005330_cardiomyopathy1.17598989
58MP0005385_cardiovascular_system_phenoty1.17157525
59MP0001544_abnormal_cardiovascular_syste1.17157525
60MP0004185_abnormal_adipocyte_glucose1.15135519
61MP0002128_abnormal_blood_circulation1.12856088
62MP0005165_increased_susceptibility_to1.12575768
63MP0001661_extended_life_span1.10386957
64MP0009250_abnormal_appendicular_skeleto1.09814651
65MP0001614_abnormal_blood_vessel1.08905658
66MP0000230_abnormal_systemic_arterial1.08396514
67MP0000534_abnormal_ureter_morphology1.08029713
68MP0002896_abnormal_bone_mineralization1.07764535
69MP0001243_abnormal_dermal_layer1.06884304
70MP0009780_abnormal_chondrocyte_physiolo1.05813521
71MP0009115_abnormal_fat_cell1.05794400
72MP0009379_abnormal_foot_pigmentation1.04782104
73MP0000249_abnormal_blood_vessel1.04683257
74MP0001756_abnormal_urination1.04082614
75MP0001666_abnormal_nutrient_absorption1.03629692
76MP0004215_abnormal_myocardial_fiber1.03105893
77MP0004019_abnormal_vitamin_homeostasis1.02658391
78MP0010352_gastrointestinal_tract_polyps1.00156902
79MP0005332_abnormal_amino_acid0.99801084
80MP0002332_abnormal_exercise_endurance0.99568678
81MP0002282_abnormal_trachea_morphology0.98967857
82MP0003385_abnormal_body_wall0.98247022
83MP0004087_abnormal_muscle_fiber0.97908473
84MP0005390_skeleton_phenotype0.97790697
85MP0002118_abnormal_lipid_homeostasis0.96917868
86MP0003950_abnormal_plasma_membrane0.96712778
87MP0003879_abnormal_hair_cell0.96684601
88MP0002060_abnormal_skin_morphology0.95592314
89MP0001188_hyperpigmentation0.92662989
90MP0005084_abnormal_gallbladder_morpholo0.91638118
91MP0002127_abnormal_cardiovascular_syste0.91098106
92MP0005670_abnormal_white_adipose0.90379166
93MP0005334_abnormal_fat_pad0.89178295
94MP0002168_other_aberrant_phenotype0.87314102
95MP0003045_fibrosis0.86580171
96MP0009643_abnormal_urine_homeostasis0.86549382
97MP0003942_abnormal_urinary_system0.85293815
98MP0010386_abnormal_urinary_bladder0.83925295
99MP0002925_abnormal_cardiovascular_devel0.83833169
100MP0002269_muscular_atrophy0.83609056
101MP0002970_abnormal_white_adipose0.83478238
102MP0000462_abnormal_digestive_system0.83257886
103MP0000759_abnormal_skeletal_muscle0.83047036
104MP0005257_abnormal_intraocular_pressure0.82155799
105MP0000163_abnormal_cartilage_morphology0.80459985
106MP0003646_muscle_fatigue0.80265780
107MP0004858_abnormal_nervous_system0.79871266
108MP0005409_darkened_coat_color0.79853096
109MP0003806_abnormal_nucleotide_metabolis0.77348349
110MP0001881_abnormal_mammary_gland0.77255480
111MP0003690_abnormal_glial_cell0.77093754
112MP0010630_abnormal_cardiac_muscle0.76833877
113MP0000003_abnormal_adipose_tissue0.76752964
114MP0005647_abnormal_sex_gland0.76334844
115MP0005535_abnormal_body_temperature0.75458081
116MP0000747_muscle_weakness0.75432619
117MP0000733_abnormal_muscle_development0.75283040
118MP0002115_abnormal_skeleton_extremities0.74696726
119MP0001533_abnormal_skeleton_physiology0.74007099
120MP0005369_muscle_phenotype0.73529698
121MP0005388_respiratory_system_phenotype0.73473160
122MP0002133_abnormal_respiratory_system0.73473160
123MP0004883_abnormal_blood_vessel0.72257870
124MP0001764_abnormal_homeostasis0.71438987
125MP0004134_abnormal_chest_morphology0.70474341
126MP0002837_dystrophic_cardiac_calcinosis0.68804815
127MP0000266_abnormal_heart_morphology0.68545792
128MP0003137_abnormal_impulse_conducting0.67303832
129MP0001299_abnormal_eye_distance/0.67106469
130MP0002933_joint_inflammation0.67066963
131MP0004233_abnormal_muscle_weight0.66710806
132MP0005367_renal/urinary_system_phenotyp0.64685168
133MP0000516_abnormal_urinary_system0.64685168
134MP0005171_absent_coat_pigmentation0.64547353
135MP0006276_abnormal_autonomic_nervous0.63894850
136MP0003186_abnormal_redox_activity0.62800813
137MP0002106_abnormal_muscle_physiology0.62100532
138MP0000538_abnormal_urinary_bladder0.61603840
139MP0000537_abnormal_urethra_morphology0.61031498
140MP0005379_endocrine/exocrine_gland_phen0.58672318

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.69910536
2Protrusio acetabuli (HP:0003179)6.67263099
3Aortic dissection (HP:0002647)4.68144235
4Aortic aneurysm (HP:0004942)4.66311324
5Complement deficiency (HP:0004431)4.12569504
6Systemic lupus erythematosus (HP:0002725)3.91851315
7Cerebral aneurysm (HP:0004944)3.85419465
8Increased connective tissue (HP:0009025)3.82055410
9Soft skin (HP:0000977)3.73666140
10Muscle fiber splitting (HP:0003555)3.61443378
11Abnormality of complement system (HP:0005339)3.58793307
12Spinal rigidity (HP:0003306)3.54466547
13Nonimmune hydrops fetalis (HP:0001790)3.50394303
14Wrist flexion contracture (HP:0001239)3.48686806
15Atrophic scars (HP:0001075)3.43338251
16Abnormality of dentin (HP:0010299)3.39631929
17Type 1 muscle fiber predominance (HP:0003803)3.39443257
18Peritonitis (HP:0002586)3.35547981
19Dilatation of the ascending aorta (HP:0005111)3.33753378
20Broad metatarsal (HP:0001783)3.27404177
21Vascular tortuosity (HP:0004948)3.24111482
22Polycythemia (HP:0001901)3.22151289
23Ankle contracture (HP:0006466)3.14197316
24Difficulty climbing stairs (HP:0003551)3.12909476
25Vertebral compression fractures (HP:0002953)3.12793838
26Cervical subluxation (HP:0003308)3.06553903
27Fragile skin (HP:0001030)3.05878495
28Shallow orbits (HP:0000586)2.96999997
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92579322
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86352507
31Oligomenorrhea (HP:0000876)2.85217337
32Wormian bones (HP:0002645)2.80637565
33Hyporeflexia of lower limbs (HP:0002600)2.78428757
34Round ear (HP:0100830)2.75488779
35Hydroxyprolinuria (HP:0003080)2.74160998
36Abnormality of proline metabolism (HP:0010907)2.74160998
37Hematochezia (HP:0002573)2.72565474
38Short nail (HP:0001799)2.69884024
39Distal arthrogryposis (HP:0005684)2.66096036
40Arterial tortuosity (HP:0005116)2.64817863
41Bladder diverticulum (HP:0000015)2.63294631
42Overgrowth (HP:0001548)2.60128310
43Distal lower limb muscle weakness (HP:0009053)2.58975038
44Right ventricular cardiomyopathy (HP:0011663)2.52549023
45Aneurysm (HP:0002617)2.51316436
46Increased variability in muscle fiber diameter (HP:0003557)2.50344011
47Intrahepatic cholestasis (HP:0001406)2.49659369
48Acanthosis nigricans (HP:0000956)2.46499817
49Mesangial abnormality (HP:0001966)2.45698770
50Blue sclerae (HP:0000592)2.45538840
51Mildly elevated creatine phosphokinase (HP:0008180)2.41642559
52Hyperglycinuria (HP:0003108)2.41258500
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37379803
54Coronal craniosynostosis (HP:0004440)2.35062295
55Abnormality of the nasal mucosa (HP:0000433)2.32877680
56Glomerulonephritis (HP:0000099)2.32445521
57Abnormality of skeletal muscle fiber size (HP:0012084)2.30734692
58Genu recurvatum (HP:0002816)2.29038788
59Biconcave vertebral bodies (HP:0004586)2.28459670
60Absent phalangeal crease (HP:0006109)2.25978341
61Muscle fiber inclusion bodies (HP:0100299)2.25838766
62Abnormal delivery (HP:0001787)2.25778321
63Asymmetric septal hypertrophy (HP:0001670)2.22697752
64Venous abnormality (HP:0002624)2.21915911
65Abnormality of the acetabulum (HP:0003170)2.21831549
66Knee flexion contracture (HP:0006380)2.20305067
67Coxa vara (HP:0002812)2.20109497
68Abnormality of glycine metabolism (HP:0010895)2.19718692
69Abnormality of serine family amino acid metabolism (HP:0010894)2.19718692
70Mitral valve prolapse (HP:0001634)2.19462727
71Neonatal short-limb short stature (HP:0008921)2.18723409
72Cupped ribs (HP:0000887)2.18034340
73Growth hormone excess (HP:0000845)2.17924761
74Follicular hyperkeratosis (HP:0007502)2.17048154
75Abnormality of the calf musculature (HP:0001430)2.16129184
76Chondrocalcinosis (HP:0000934)2.13962713
77Exercise-induced myalgia (HP:0003738)2.13292918
78Neck muscle weakness (HP:0000467)2.12836269
79Rhabdomyolysis (HP:0003201)2.11811919
80Bundle branch block (HP:0011710)2.11205448
81Nemaline bodies (HP:0003798)2.11139485
82Calcaneovalgus deformity (HP:0001848)2.10333485
83Aortic regurgitation (HP:0001659)2.10205059
84Abnormality of carpal bone ossification (HP:0006257)2.08934598
85Hyperextensible skin (HP:0000974)2.08152983
86Hyperlipoproteinemia (HP:0010980)2.07616454
87Camptodactyly of toe (HP:0001836)2.05510293
88Calf muscle hypertrophy (HP:0008981)2.05394349
89Myoglobinuria (HP:0002913)2.05149914
90Venous insufficiency (HP:0005293)2.04273873
91EMG: myopathic abnormalities (HP:0003458)2.04036275
92Nephritis (HP:0000123)2.03984239
93Cerebral palsy (HP:0100021)2.03556791
94Short hallux (HP:0010109)2.03326781
95Bulbar palsy (HP:0001283)2.02700195
96Ulnar deviation of the wrist (HP:0003049)2.00335124
97Hip contracture (HP:0003273)2.00297179
98Focal segmental glomerulosclerosis (HP:0000097)2.00279345
99Deformed tarsal bones (HP:0008119)2.00232356
100Abnormality of Sharpey fibers (HP:0100685)1.98277775
101Osteolytic defects of the hand bones (HP:0009699)1.96882264
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.96882264
103Conjugated hyperbilirubinemia (HP:0002908)1.96688723
104Elbow flexion contracture (HP:0002987)1.96073144
105Ileus (HP:0002595)1.95057906
106Sudden death (HP:0001699)1.94069535
107Conjunctival telangiectasia (HP:0000524)1.94040164
108Ectopia lentis (HP:0001083)1.93094327
109Muscle hypertrophy of the lower extremities (HP:0008968)1.90640681
110Platyspondyly (HP:0000926)1.90365715
111Cardiovascular calcification (HP:0011915)1.88269897
112Aplasia/Hypoplasia of the hallux (HP:0008362)1.88121292
113Abnormal atrioventricular conduction (HP:0005150)1.86821533
114Pulmonary artery stenosis (HP:0004415)1.86651215
115Joint laxity (HP:0001388)1.86094179
116Hypoplastic ischia (HP:0003175)1.85976907
117Osteoarthritis (HP:0002758)1.85880551
118Scapular winging (HP:0003691)1.85858075
119Esophageal varix (HP:0002040)1.83714246
120Increased serum pyruvate (HP:0003542)1.83592471
121Joint stiffness (HP:0001387)1.83457285
122Muscle fibrillation (HP:0010546)1.82953492
123Xanthomatosis (HP:0000991)1.81464597
124Heart block (HP:0012722)1.81137724
125Back pain (HP:0003418)1.80558612
126Myopathic facies (HP:0002058)1.79033670
127Abnormal finger flexion creases (HP:0006143)1.78970539
128Malnutrition (HP:0004395)1.78605742
129Wide anterior fontanel (HP:0000260)1.78201821
130Lipoatrophy (HP:0100578)1.77814144
131Fat malabsorption (HP:0002630)1.77661770
132Gowers sign (HP:0003391)1.77597192
133Redundant skin (HP:0001582)1.77555736
134Choanal stenosis (HP:0000452)1.77252983
135Hypertriglyceridemia (HP:0002155)1.77241922
136Lymphangioma (HP:0100764)1.76580276
137Hemorrhage of the eye (HP:0011885)1.76037424
138Skin nodule (HP:0200036)1.76001810
139Limited hip movement (HP:0008800)1.75899810
140Abnormality of the calcaneus (HP:0008364)1.75896138
141Abnormality of the ischium (HP:0003174)1.75293507
142Decreased circulating renin level (HP:0003351)1.75193595
143Aortic valve stenosis (HP:0001650)1.74390702
144Osteopenia (HP:0000938)1.72034473
145Areflexia of lower limbs (HP:0002522)1.71831202
146Abnormality of glycolysis (HP:0004366)1.71028558
147Muscular dystrophy (HP:0003560)1.70586268
148Difficulty running (HP:0009046)1.70497950
149Mitral stenosis (HP:0001718)1.70092926
150Hyperactive renin-angiotensin system (HP:0000841)1.70021770
151Ventricular tachycardia (HP:0004756)1.69737627
152Mitral regurgitation (HP:0001653)1.69598403
153Renal tubular acidosis (HP:0001947)1.69004482
154Turricephaly (HP:0000262)1.67555687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.84617845
2KDR5.81621774
3PDK23.22400626
4RIPK12.87217854
5LATS22.85430921
6TESK12.79241188
7TGFBR22.72429051
8MYLK2.62595682
9EPHB22.47751352
10TTN2.45422311
11PIK3CA2.22153523
12DDR22.03392024
13PDK41.98868743
14PDK31.98868743
15ERN11.96969295
16PTK2B1.94104790
17WNK41.91182730
18TGFBR11.88884767
19LIMK11.88661495
20CAMK1D1.85875771
21AKT31.82807296
22FER1.71397900
23TRIB31.54239671
24STK38L1.53704660
25PRKD21.53503215
26CAMK1G1.51032272
27EEF2K1.49877648
28MAP3K31.45618349
29PDGFRA1.44297393
30MAPKAPK31.35772845
31FRK1.35064350
32PIK3CG1.31838866
33LATS11.27659507
34PRKAA21.26462905
35PIM21.26195128
36PAK21.23318236
37CAMK11.14587888
38PTK21.12569004
39MAP2K31.09655093
40STK391.09298830
41MAP2K11.07962305
42MAP3K111.05861900
43MOS1.01805974
44SIK11.01730722
45GRK51.00784658
46EPHA21.00062886
47MAP2K60.97900750
48TRPM70.94474274
49ZAK0.94115799
50PAK40.92431851
51MAP3K120.89419558
52TNK20.88043566
53NME20.87804035
54PAK30.87613843
55ROCK10.87156716
56EPHA30.86222568
57PRKG20.83694383
58TESK20.83289199
59MARK10.83062407
60NTRK10.82980341
61ERBB30.81245566
62SGK4940.79824528
63SGK2230.79824528
64CDC42BPA0.77967120
65TAOK20.76941464
66MAPK120.75546736
67OBSCN0.75389640
68ARAF0.75347893
69CAMK2G0.74764028
70OXSR10.71524246
71ABL20.71478664
72PRKAA10.71007610
73MET0.70885055
74PDGFRB0.70692454
75NLK0.69465723
76LRRK20.68734985
77STK380.66526813
78LMTK20.65332807
79EPHB10.65087741
80CAMK2D0.64915342
81MAP3K60.64486555
82NEK90.63911141
83CASK0.60971319
84PRKCE0.59346237
85NME10.58368188
86PRKACG0.57706588
87PBK0.56030417
88STK100.55316434
89PTK60.55279223
90MAP2K20.54897950
91PLK20.53328308
92MAPK40.53069974
93MAP3K70.52868279
94ACVR1B0.52759727
95STK30.51568377
96PRKD10.50431749
97MUSK0.49859032
98NEK10.49655287
99ROCK20.49639540
100PAK10.46538411
101PRKG10.44425721
102EIF2AK10.44133555
103WNK30.43166232
104RPS6KA40.41589933
105PINK10.41550105
106ILK0.40830549
107FGFR40.40786533
108PRKCH0.39881038
109ADRBK10.39212912
110PRKD30.39001202
111MARK20.38995524
112PHKG20.37659237
113PHKG10.37659237
114SGK20.37359121
115BCKDK0.36887114
116TAOK10.36469389
117CAMK2A0.35586625
118CAMK2B0.35435569
119PKN20.34885363
120BMX0.33304600
121PKN10.33057004
122MAPKAPK50.32334315
123MAP3K80.31925425
124PRKCA0.31749926
125GSK3A0.31218547
126MTOR0.29940200
127DMPK0.29807534
128CDK50.29743847
129GRK10.29345859
130PRKCZ0.29083457
131DAPK30.28330520
132MINK10.27123754
133CDK140.25177611
134MAP3K50.24747952
135BRAF0.23066264
136BUB10.22359431
137FGFR10.21801737
138IGF1R0.21670471
139MAPK70.21625732
140INSR0.20706695
141EGFR0.20637623
142MARK30.20583032
143SRC0.19804991
144BCR0.18809394

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.99797654
2Focal adhesion_Homo sapiens_hsa045102.92258213
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.85228229
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.62953426
5Dilated cardiomyopathy_Homo sapiens_hsa054142.58825353
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41569337
7Histidine metabolism_Homo sapiens_hsa003402.38858465
8Protein digestion and absorption_Homo sapiens_hsa049742.33791578
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33736269
10Malaria_Homo sapiens_hsa051442.27783195
11Proteasome_Homo sapiens_hsa030502.24090883
12Fatty acid biosynthesis_Homo sapiens_hsa000612.20126729
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05359501
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.04834552
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01269968
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.96631455
17Adherens junction_Homo sapiens_hsa045201.93625363
18Arginine biosynthesis_Homo sapiens_hsa002201.91777487
19TGF-beta signaling pathway_Homo sapiens_hsa043501.80552752
20Amoebiasis_Homo sapiens_hsa051461.76939616
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73544916
22Fatty acid metabolism_Homo sapiens_hsa012121.72779399
23Retinol metabolism_Homo sapiens_hsa008301.71841702
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70921704
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69295417
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.68364242
27Proteoglycans in cancer_Homo sapiens_hsa052051.67219870
28Tight junction_Homo sapiens_hsa045301.65715224
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64877376
30Renin-angiotensin system_Homo sapiens_hsa046141.64006409
31Tryptophan metabolism_Homo sapiens_hsa003801.58472609
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57157619
33beta-Alanine metabolism_Homo sapiens_hsa004101.52269790
34Fatty acid elongation_Homo sapiens_hsa000621.47436464
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46996265
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42064697
37Butanoate metabolism_Homo sapiens_hsa006501.40991552
38Small cell lung cancer_Homo sapiens_hsa052221.37878487
39Hippo signaling pathway_Homo sapiens_hsa043901.37257183
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.34227786
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26954494
42Bladder cancer_Homo sapiens_hsa052191.24822885
43Shigellosis_Homo sapiens_hsa051311.24184012
44Phagosome_Homo sapiens_hsa041451.23773891
45Cardiac muscle contraction_Homo sapiens_hsa042601.23043925
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.21217147
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21033512
48Bile secretion_Homo sapiens_hsa049761.20257455
49Ovarian steroidogenesis_Homo sapiens_hsa049131.18842070
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16850005
51Rap1 signaling pathway_Homo sapiens_hsa040151.16243047
52Sulfur metabolism_Homo sapiens_hsa009201.16047142
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15311115
54Salmonella infection_Homo sapiens_hsa051321.15254974
55Glycerolipid metabolism_Homo sapiens_hsa005611.14641762
56AMPK signaling pathway_Homo sapiens_hsa041521.10364686
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09973561
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09508038
59Glutathione metabolism_Homo sapiens_hsa004801.04482863
60Mineral absorption_Homo sapiens_hsa049781.04332964
61Biosynthesis of amino acids_Homo sapiens_hsa012301.03653488
62HIF-1 signaling pathway_Homo sapiens_hsa040661.02081821
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00246475
64TNF signaling pathway_Homo sapiens_hsa046680.99100650
65Parkinsons disease_Homo sapiens_hsa050120.97049338
66Vitamin digestion and absorption_Homo sapiens_hsa049770.97007620
67Vitamin B6 metabolism_Homo sapiens_hsa007500.96749563
68p53 signaling pathway_Homo sapiens_hsa041150.94934071
69Rheumatoid arthritis_Homo sapiens_hsa053230.94209899
70Peroxisome_Homo sapiens_hsa041460.93664795
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93003164
72Huntingtons disease_Homo sapiens_hsa050160.91458297
73Oxidative phosphorylation_Homo sapiens_hsa001900.90727741
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88345328
75Complement and coagulation cascades_Homo sapiens_hsa046100.88299182
76Galactose metabolism_Homo sapiens_hsa000520.86514971
77Vibrio cholerae infection_Homo sapiens_hsa051100.86378298
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84674155
79Pyruvate metabolism_Homo sapiens_hsa006200.82833256
80Arginine and proline metabolism_Homo sapiens_hsa003300.82512851
81Folate biosynthesis_Homo sapiens_hsa007900.80026227
82Gap junction_Homo sapiens_hsa045400.77237923
83Melanoma_Homo sapiens_hsa052180.75704962
84PPAR signaling pathway_Homo sapiens_hsa033200.74551560
85Renin secretion_Homo sapiens_hsa049240.74542449
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74215122
87Viral myocarditis_Homo sapiens_hsa054160.72667700
88Glucagon signaling pathway_Homo sapiens_hsa049220.68851053
89Pentose phosphate pathway_Homo sapiens_hsa000300.67719795
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.67108446
91Carbon metabolism_Homo sapiens_hsa012000.66934631
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66647425
93Caffeine metabolism_Homo sapiens_hsa002320.66532113
94Circadian rhythm_Homo sapiens_hsa047100.66505014
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.66253717
96Arachidonic acid metabolism_Homo sapiens_hsa005900.64507668
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64211764
98Sphingolipid metabolism_Homo sapiens_hsa006000.63991771
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63341752
100Alzheimers disease_Homo sapiens_hsa050100.62800804
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62788769
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62560682
103Toxoplasmosis_Homo sapiens_hsa051450.61990345
104Linoleic acid metabolism_Homo sapiens_hsa005910.59484125
105Fat digestion and absorption_Homo sapiens_hsa049750.57779455
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57489356
107Axon guidance_Homo sapiens_hsa043600.57389944
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57177466
109Pathways in cancer_Homo sapiens_hsa052000.56269778
110Ras signaling pathway_Homo sapiens_hsa040140.55618883
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55211432
112VEGF signaling pathway_Homo sapiens_hsa043700.53770292
113Legionellosis_Homo sapiens_hsa051340.53603975
114MicroRNAs in cancer_Homo sapiens_hsa052060.51989498
115Platelet activation_Homo sapiens_hsa046110.51757509
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51725361
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51033887
118Apoptosis_Homo sapiens_hsa042100.50498424
119Thyroid hormone synthesis_Homo sapiens_hsa049180.50239436
120African trypanosomiasis_Homo sapiens_hsa051430.49935869
121Endocytosis_Homo sapiens_hsa041440.49641666
122Sulfur relay system_Homo sapiens_hsa041220.49210547
123Tyrosine metabolism_Homo sapiens_hsa003500.49098787
124Propanoate metabolism_Homo sapiens_hsa006400.48328139
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47943203
126Prion diseases_Homo sapiens_hsa050200.46944190
127Insulin resistance_Homo sapiens_hsa049310.46471427
128Insulin signaling pathway_Homo sapiens_hsa049100.46156039
129Starch and sucrose metabolism_Homo sapiens_hsa005000.45548231
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45514827
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42972833
132Cocaine addiction_Homo sapiens_hsa050300.42206927
133Fatty acid degradation_Homo sapiens_hsa000710.41383919
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41132215
135Pertussis_Homo sapiens_hsa051330.39200961
136Pancreatic secretion_Homo sapiens_hsa049720.37826279
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.37670748
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37127745
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37002713
140Chemical carcinogenesis_Homo sapiens_hsa052040.36866799
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.36611641
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36348604
143Fructose and mannose metabolism_Homo sapiens_hsa000510.36033238
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35921685
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.35797247
146ABC transporters_Homo sapiens_hsa020100.35591020
147Metabolic pathways_Homo sapiens_hsa011000.33265674
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32810367
149Phenylalanine metabolism_Homo sapiens_hsa003600.32590355
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32128383
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.28160828

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