PLPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.52917974
2cilium or flagellum-dependent cell motility (GO:0001539)6.25738365
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.77089186
4cilium movement (GO:0003341)5.71461910
5epithelial cilium movement (GO:0003351)5.35082439
6motile cilium assembly (GO:0044458)5.08363990
7intestinal absorption (GO:0050892)4.51153794
8axoneme assembly (GO:0035082)4.46962093
9hemidesmosome assembly (GO:0031581)4.41744730
10negative regulation of T cell differentiation in thymus (GO:0033085)3.98500257
11regulation of cilium movement (GO:0003352)3.84252583
12behavioral response to nicotine (GO:0035095)3.79252321
13intestinal cholesterol absorption (GO:0030299)3.77384323
14bundle of His cell to Purkinje myocyte communication (GO:0086069)3.75296108
15L-fucose catabolic process (GO:0042355)3.69435108
16fucose catabolic process (GO:0019317)3.69435108
17L-fucose metabolic process (GO:0042354)3.69435108
18sulfur amino acid catabolic process (GO:0000098)3.64194039
19vitamin transmembrane transport (GO:0035461)3.60369674
20pentose-phosphate shunt (GO:0006098)3.51719480
21NADPH regeneration (GO:0006740)3.49720164
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.40501218
23virion attachment to host cell (GO:0019062)3.39814076
24adhesion of symbiont to host cell (GO:0044650)3.39814076
25water-soluble vitamin biosynthetic process (GO:0042364)3.33049754
26response to xenobiotic stimulus (GO:0009410)3.29909837
27actin filament depolymerization (GO:0030042)3.29392185
28sulfation (GO:0051923)3.27048480
29flavonoid metabolic process (GO:0009812)3.21416465
30desmosome organization (GO:0002934)3.16036551
31glutathione derivative metabolic process (GO:1901685)3.15635836
32glutathione derivative biosynthetic process (GO:1901687)3.15635836
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.10779401
34left/right pattern formation (GO:0060972)3.06077022
35L-phenylalanine metabolic process (GO:0006558)3.05170769
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05170769
37lung epithelium development (GO:0060428)3.02833399
38adhesion of symbiont to host (GO:0044406)3.02041090
39cysteine metabolic process (GO:0006534)2.99706307
40hepatocyte apoptotic process (GO:0097284)2.98882889
41cellular glucuronidation (GO:0052695)2.98065045
42glucuronate metabolic process (GO:0019585)2.94949918
43uronic acid metabolic process (GO:0006063)2.94949918
44amyloid precursor protein catabolic process (GO:0042987)2.94208147
45establishment of apical/basal cell polarity (GO:0035089)2.93690258
46cilium organization (GO:0044782)2.92988809
47amyloid precursor protein metabolic process (GO:0042982)2.87490020
48negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.86736308
49regulation of hippo signaling (GO:0035330)2.86723911
50cornea development in camera-type eye (GO:0061303)2.85076256
51cholesterol biosynthetic process (GO:0006695)2.85001313
52negative regulation of telomere maintenance (GO:0032205)2.84764243
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84286107
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84286107
55pseudouridine synthesis (GO:0001522)2.83223824
56angiotensin maturation (GO:0002003)2.82370978
57cilium assembly (GO:0042384)2.81285785
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81019392
59respiratory chain complex IV assembly (GO:0008535)2.80952869
60positive regulation of actin filament depolymerization (GO:0030836)2.80942454
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.80922068
62NADH dehydrogenase complex assembly (GO:0010257)2.80922068
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80922068
64establishment or maintenance of monopolar cell polarity (GO:0061339)2.80860455
65establishment of monopolar cell polarity (GO:0061162)2.80860455
66bile acid and bile salt transport (GO:0015721)2.77404543
67response to nitrosative stress (GO:0051409)2.76815275
68regulation of posttranscriptional gene silencing (GO:0060147)2.76731193
69regulation of gene silencing by miRNA (GO:0060964)2.76731193
70regulation of gene silencing by RNA (GO:0060966)2.76731193
71interferon-gamma secretion (GO:0072643)2.75962429
72cilium morphogenesis (GO:0060271)2.73776299
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73028622
74regulation of microtubule-based movement (GO:0060632)2.71459222
75L-phenylalanine catabolic process (GO:0006559)2.70679055
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70679055
77positive regulation of prostaglandin secretion (GO:0032308)2.70641225
78microtubule bundle formation (GO:0001578)2.69399641
79cell adhesion mediated by integrin (GO:0033627)2.68651505
80regulation of retinoic acid receptor signaling pathway (GO:0048385)2.68512237
81GTP biosynthetic process (GO:0006183)2.68413977
82cellular ketone body metabolic process (GO:0046950)2.68289780
83fatty acid elongation (GO:0030497)2.67084308
84maintenance of gastrointestinal epithelium (GO:0030277)2.65283250
85exogenous drug catabolic process (GO:0042738)2.65050090
86primary alcohol catabolic process (GO:0034310)2.64999955
87glucose catabolic process (GO:0006007)2.64636012
88protein complex biogenesis (GO:0070271)2.63757295
89mesodermal cell differentiation (GO:0048333)2.63598418
90retinoic acid metabolic process (GO:0042573)2.63594655
91heme transport (GO:0015886)2.62455324
92membrane budding (GO:0006900)2.61329570
93glutathione biosynthetic process (GO:0006750)2.61293416
94protein polyglutamylation (GO:0018095)2.61141131
95multicellular organism reproduction (GO:0032504)2.61048349
96kynurenine metabolic process (GO:0070189)2.59371015
97diterpenoid biosynthetic process (GO:0016102)2.58568387
98protein localization to cilium (GO:0061512)2.58538841
99positive regulation of triglyceride lipase activity (GO:0061365)2.57942230
100positive regulation of lipoprotein lipase activity (GO:0051006)2.57942230
101regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57616480
102regulation of cholesterol homeostasis (GO:2000188)2.56668446
103regulation of cholesterol metabolic process (GO:0090181)2.56631230
104positive regulation of pseudopodium assembly (GO:0031274)2.56077423
105cellular response to vitamin D (GO:0071305)2.55556975
106ethanol metabolic process (GO:0006067)2.55379925
107tight junction assembly (GO:0070830)2.55373575
108sterol homeostasis (GO:0055092)2.55364715
109nucleoside diphosphate phosphorylation (GO:0006165)2.55202805
110pyrimidine-containing compound transmembrane transport (GO:0072531)2.54660043
111cholesterol homeostasis (GO:0042632)2.54509576
112aldehyde catabolic process (GO:0046185)2.53118528
113skin morphogenesis (GO:0043589)2.53006217
114sterol biosynthetic process (GO:0016126)2.52534708
115keratinocyte proliferation (GO:0043616)2.52344873
116triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.52252488
117lipoprotein metabolic process (GO:0042157)2.52123719
118vitamin A metabolic process (GO:0006776)2.52080967
119mitochondrial respiratory chain complex assembly (GO:0033108)2.51981672
120DNA deamination (GO:0045006)2.50807553
121epithelial cell-cell adhesion (GO:0090136)2.50230528
122proteasome assembly (GO:0043248)2.49470437
123protein-lipid complex assembly (GO:0065005)2.48717659
124regulation of triglyceride catabolic process (GO:0010896)2.48550984
125UTP biosynthetic process (GO:0006228)2.48350277
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47729806
127drug catabolic process (GO:0042737)2.47272228
128intraciliary transport (GO:0042073)2.46607664
129maturation of 5.8S rRNA (GO:0000460)2.46372683
130termination of RNA polymerase III transcription (GO:0006386)2.46023616
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.46023616
132rRNA catabolic process (GO:0016075)2.45141276
133negative regulation of sterol transport (GO:0032372)2.44646858
134negative regulation of cholesterol transport (GO:0032375)2.44646858
135NADP metabolic process (GO:0006739)2.44571716
136xenobiotic catabolic process (GO:0042178)2.44520894
137hexose catabolic process (GO:0019320)2.44476733
138fucosylation (GO:0036065)2.44320634
139serine family amino acid biosynthetic process (GO:0009070)2.43946118
140peptidyl-histidine modification (GO:0018202)2.43445797
141low-density lipoprotein particle clearance (GO:0034383)2.42765425
142mannosylation (GO:0097502)2.42351910
143hydrogen peroxide catabolic process (GO:0042744)2.41832664
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40915115
145DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.40842038
146regulation of metalloenzyme activity (GO:0048552)2.40830711
147mitochondrial RNA metabolic process (GO:0000959)2.40351539
148indolalkylamine metabolic process (GO:0006586)2.40198057
149nucleotide transmembrane transport (GO:1901679)2.39902120
150negative regulation of keratinocyte proliferation (GO:0010839)2.39799764
151ubiquinone biosynthetic process (GO:0006744)2.39290698
152positive regulation of fatty acid transport (GO:2000193)2.39020857
153preassembly of GPI anchor in ER membrane (GO:0016254)2.38978205
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.37958259
155nonribosomal peptide biosynthetic process (GO:0019184)2.37810940
156ketone body metabolic process (GO:1902224)2.36625581
157regulation of cholesterol esterification (GO:0010872)2.36199777
158piRNA metabolic process (GO:0034587)2.35904482
159glutathione metabolic process (GO:0006749)2.34998326
160glyoxylate metabolic process (GO:0046487)2.33944138
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33929360
1624-hydroxyproline metabolic process (GO:0019471)2.33573837
163left/right axis specification (GO:0070986)2.33532082
164tRNA modification (GO:0006400)2.33498581
165rRNA modification (GO:0000154)2.33196386
166purine ribonucleotide transport (GO:0015868)2.33140420
167one-carbon compound transport (GO:0019755)2.32811356
168primary amino compound metabolic process (GO:1901160)2.32693694
169regulation of chemokine secretion (GO:0090196)2.32489333
170DNA damage response, signal transduction resulting in transcription (GO:0042772)2.31973095
171mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31919684
172organic cation transport (GO:0015695)2.31492426
173photoreceptor cell maintenance (GO:0045494)2.31348654
174O-glycan processing (GO:0016266)2.31207997
175tryptophan catabolic process (GO:0006569)2.30643169
176indole-containing compound catabolic process (GO:0042436)2.30643169
177indolalkylamine catabolic process (GO:0046218)2.30643169
178regulation of early endosome to late endosome transport (GO:2000641)2.30211719
179galactose catabolic process (GO:0019388)2.30031471
180pentose metabolic process (GO:0019321)2.29131973
181plasma lipoprotein particle assembly (GO:0034377)2.28690826
182plasma lipoprotein particle clearance (GO:0034381)2.28488856
183drug transport (GO:0015893)2.28100536
184drug transmembrane transport (GO:0006855)2.27740619
185digestive system process (GO:0022600)2.27532557
186phospholipid efflux (GO:0033700)2.26776765
187L-ascorbic acid metabolic process (GO:0019852)2.26437016
188cellular response to vitamin (GO:0071295)2.26162663
189positive regulation of fatty acid biosynthetic process (GO:0045723)2.25510663
190positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.25168583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.80316188
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.49317426
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20657477
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39384753
5ZNF274_21170338_ChIP-Seq_K562_Hela3.38566648
6VDR_22108803_ChIP-Seq_LS180_Human3.26101794
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01124380
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95324781
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.91905725
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78834476
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.67418823
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64416255
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.36624034
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.32437441
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31578308
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.26250455
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26042256
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24376384
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.18910223
20SOX2_20726797_ChIP-Seq_SW620_Human2.18421511
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14991837
22CLOCK_20551151_ChIP-Seq_293T_Human2.12698784
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.12219543
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11588043
25GATA4_25053715_ChIP-Seq_YYC3_Human2.05743166
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03222742
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.02733593
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94209621
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.91747245
30GATA6_25053715_ChIP-Seq_YYC3_Human1.89502410
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86405429
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84888044
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82130895
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80109400
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79048155
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77954822
37RACK7_27058665_Chip-Seq_MCF-7_Human1.75740695
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75489372
39ATF3_27146783_Chip-Seq_COLON_Human1.74732579
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74251077
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72800837
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70948510
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.70106743
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66355985
45AR_21909140_ChIP-Seq_LNCAP_Human1.66092272
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63733936
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63733936
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61173104
49ERA_21632823_ChIP-Seq_H3396_Human1.57858614
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57404662
51ZNF263_19887448_ChIP-Seq_K562_Human1.55932454
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.55584132
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54187909
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52298721
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.48251214
56MYC_18940864_ChIP-ChIP_HL60_Human1.47994379
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47945698
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47155615
59HOXB7_26014856_ChIP-Seq_BT474_Human1.47131980
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44061473
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.42098162
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41930265
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40726001
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39759776
65PHF8_20622854_ChIP-Seq_HELA_Human1.39607467
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39559871
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37437368
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37012342
69P53_21459846_ChIP-Seq_SAOS-2_Human1.34707853
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.32897028
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32897028
72CTCF_20526341_ChIP-Seq_ESCs_Human1.32295352
73E2F1_20622854_ChIP-Seq_HELA_Human1.31418847
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30081704
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28763061
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26984037
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26023857
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25320248
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24709964
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.23920796
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.23301018
82DROSHA_22980978_ChIP-Seq_HELA_Human1.22745551
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21806261
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21484990
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21237061
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20470192
87STAT1_20625510_ChIP-Seq_HELA_Human1.20466711
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20450794
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19499180
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19269292
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.19187678
92P68_20966046_ChIP-Seq_HELA_Human1.18214355
93IRF1_19129219_ChIP-ChIP_H3396_Human1.18149918
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17571935
95TP53_22573176_ChIP-Seq_HFKS_Human1.17442346
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17194191
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16806656
98OCT4_20526341_ChIP-Seq_ESCs_Human1.16775011
99NANOG_20526341_ChIP-Seq_ESCs_Human1.16761701
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15874392
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.15721504
102AR_20517297_ChIP-Seq_VCAP_Human1.15708093
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15370648
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14535219
105AHR_22903824_ChIP-Seq_MCF-7_Human1.13498445
106EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13034743
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11654267
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10937762
109NCOR_22424771_ChIP-Seq_293T_Human1.10606965
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10468623
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09862697
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08919914
113TP63_22573176_ChIP-Seq_HFKS_Human1.08732824
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08650685
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06623146
116GATA3_24758297_ChIP-Seq_MCF-7_Human1.06305948
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04172505
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03954613
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.02868090
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02577587
121P300_27268052_Chip-Seq_Bcells_Human1.02439524
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02317468
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02243295
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00865857
125CTCF_27219007_Chip-Seq_Bcells_Human1.00738046
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.00557956
127TAF2_19829295_ChIP-Seq_ESCs_Human1.00193935
128MYC_19829295_ChIP-Seq_ESCs_Human0.99776824
129LXR_22292898_ChIP-Seq_THP-1_Human0.98818527
130KLF5_25053715_ChIP-Seq_YYC3_Human0.98740200
131GABP_19822575_ChIP-Seq_HepG2_Human0.98215283
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97991518
133GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97942462
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.97719645
135SOX2_21211035_ChIP-Seq_LN229_Human0.97684364
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.97567774
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.97464246
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97461974
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97045913
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96914551
141BCAT_22108803_ChIP-Seq_LS180_Human0.96104937
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95586851
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94698768
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94387808
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93783026
146ER_23166858_ChIP-Seq_MCF-7_Human0.93729841
147FOXP1_21924763_ChIP-Seq_HESCs_Human0.93504911
148TCF4_22108803_ChIP-Seq_LS180_Human0.93306205
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92906377
150UBF1/2_26484160_Chip-Seq_HMECs_Human0.92181753
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91358681
152CJUN_26792858_Chip-Seq_BT549_Human0.90452122
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90347205
154KDM5A_27292631_Chip-Seq_BREAST_Human0.89875088
155RAC3_21632823_ChIP-Seq_H3396_Human0.89347529
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89275716
157OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88698391
158PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88167376
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87688319
160BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87319518
161SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86462873
162MYC_18555785_ChIP-Seq_MESCs_Mouse0.86457853
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86420053
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.86089799
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86066691
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.86057920
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85491174
168ESR1_20079471_ChIP-ChIP_T-47D_Human0.85397285
169ELF5_23300383_ChIP-Seq_T47D_Human0.81192055
170NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80104269
171ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78730399
172FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77896581
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77637195
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77633543
175SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74444870
176VDR_21846776_ChIP-Seq_THP-1_Human0.73579113
177CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73286399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.31059812
2MP0010234_abnormal_vibrissa_follicle3.24687394
3MP0001666_abnormal_nutrient_absorption3.15394493
4MP0003705_abnormal_hypodermis_morpholog3.04891633
5MP0002139_abnormal_hepatobiliary_system2.90030573
6MP0004043_abnormal_pH_regulation2.80924877
7MP0009840_abnormal_foam_cell2.76207332
8MP0003806_abnormal_nucleotide_metabolis2.65559463
9MP0002653_abnormal_ependyma_morphology2.64055256
10MP0005085_abnormal_gallbladder_physiolo2.60878217
11MP0004133_heterotaxia2.58866528
12MP0000537_abnormal_urethra_morphology2.47115576
13MP0003718_maternal_effect2.46780518
14MP0008875_abnormal_xenobiotic_pharmacok2.25874329
15MP0004264_abnormal_extraembryonic_tissu2.18389553
16MP0010352_gastrointestinal_tract_polyps2.13904342
17MP0002796_impaired_skin_barrier2.11172516
18MP0008872_abnormal_physiological_respon2.05714668
19MP0008438_abnormal_cutaneous_collagen1.93804148
20MP0004019_abnormal_vitamin_homeostasis1.91968671
21MP0005551_abnormal_eye_electrophysiolog1.84792954
22MP0006054_spinal_hemorrhage1.84104449
23MP0005365_abnormal_bile_salt1.83578819
24MP0003693_abnormal_embryo_hatching1.82878535
25MP0000579_abnormal_nail_morphology1.81663791
26MP0000462_abnormal_digestive_system1.79462796
27MP0009384_cardiac_valve_regurgitation1.76581458
28MP0003252_abnormal_bile_duct1.74488760
29MP0005083_abnormal_biliary_tract1.72237354
30MP0003453_abnormal_keratinocyte_physiol1.71969513
31MP0001485_abnormal_pinna_reflex1.71205270
32MP0001968_abnormal_touch/_nociception1.71113816
33MP0005058_abnormal_lysosome_morphology1.66864594
34MP0002876_abnormal_thyroid_physiology1.66485143
35MP0005023_abnormal_wound_healing1.65897249
36MP0003011_delayed_dark_adaptation1.65232893
37MP0002277_abnormal_respiratory_mucosa1.64654229
38MP0003300_gastrointestinal_ulcer1.63955638
39MP0003566_abnormal_cell_adhesion1.63178245
40MP0002736_abnormal_nociception_after1.62383092
41MP0005275_abnormal_skin_tensile1.59565732
42MP0005501_abnormal_skin_physiology1.58859031
43MP0010678_abnormal_skin_adnexa1.58308112
44MP0002160_abnormal_reproductive_system1.58162154
45MP0002060_abnormal_skin_morphology1.57586752
46MP0009780_abnormal_chondrocyte_physiolo1.54596254
47MP0001986_abnormal_taste_sensitivity1.54118822
48MP0001849_ear_inflammation1.52758871
49MP0005645_abnormal_hypothalamus_physiol1.51476893
50MP0009643_abnormal_urine_homeostasis1.47993043
51MP0002098_abnormal_vibrissa_morphology1.43383522
52MP0003191_abnormal_cellular_cholesterol1.40673215
53MP0008877_abnormal_DNA_methylation1.38214865
54MP0003136_yellow_coat_color1.36638700
55MP0008004_abnormal_stomach_pH1.36039216
56MP0000490_abnormal_crypts_of1.35271663
57MP0001216_abnormal_epidermal_layer1.34696355
58MP0004885_abnormal_endolymph1.33587674
59MP0004272_abnormal_basement_membrane1.33486986
60MP0002254_reproductive_system_inflammat1.32571387
61MP0010329_abnormal_lipoprotein_level1.31249505
62MP0010155_abnormal_intestine_physiology1.30660810
63MP0005332_abnormal_amino_acid1.29251679
64MP0003186_abnormal_redox_activity1.28950696
65MP0009745_abnormal_behavioral_response1.27492496
66MP0000477_abnormal_intestine_morphology1.27018179
67MP0005257_abnormal_intraocular_pressure1.25613588
68MP0002938_white_spotting1.24755064
69MP0005408_hypopigmentation1.23362639
70MP0001873_stomach_inflammation1.23222123
71MP0001502_abnormal_circadian_rhythm1.23154171
72MP0004947_skin_inflammation1.22581129
73MP0003950_abnormal_plasma_membrane1.21681078
74MP0010030_abnormal_orbit_morphology1.21576807
75MP0003195_calcinosis1.21204770
76MP0009379_abnormal_foot_pigmentation1.20376630
77MP0001984_abnormal_olfaction1.20061954
78MP0005381_digestive/alimentary_phenotyp1.19652249
79MP0003119_abnormal_digestive_system1.18536810
80MP0005084_abnormal_gallbladder_morpholo1.18350025
81MP0002138_abnormal_hepatobiliary_system1.18029105
82MP0001663_abnormal_digestive_system1.17535231
83MP0003878_abnormal_ear_physiology1.17386748
84MP0005377_hearing/vestibular/ear_phenot1.17386748
85MP0008789_abnormal_olfactory_epithelium1.16807036
86MP0003866_abnormal_defecation1.16724228
87MP0003937_abnormal_limbs/digits/tail_de1.16141555
88MP0000383_abnormal_hair_follicle1.14773818
89MP0005395_other_phenotype1.13948825
90MP0005646_abnormal_pituitary_gland1.13896844
91MP0005389_reproductive_system_phenotype1.12810393
92MP0002102_abnormal_ear_morphology1.10598342
93MP0000631_abnormal_neuroendocrine_gland1.10055458
94MP0000377_abnormal_hair_follicle1.10021161
95MP0009053_abnormal_anal_canal1.09271306
96MP0002272_abnormal_nervous_system1.05356120
97MP0000538_abnormal_urinary_bladder1.05341434
98MP0001905_abnormal_dopamine_level1.04183156
99MP0005451_abnormal_body_composition1.04073473
100MP0006276_abnormal_autonomic_nervous1.03959723
101MP0006072_abnormal_retinal_apoptosis1.00616251
102MP0001958_emphysema0.98467646
103MP0000762_abnormal_tongue_morphology0.96243558
104MP0004147_increased_porphyrin_level0.96159955
105MP0009046_muscle_twitch0.96124154
106MP0001881_abnormal_mammary_gland0.95797438
107MP0004742_abnormal_vestibular_system0.93766635
108MP0000467_abnormal_esophagus_morphology0.93266060
109MP0001529_abnormal_vocalization0.92859534
110MP0000026_abnormal_inner_ear0.92167046
111MP0001970_abnormal_pain_threshold0.92078239
112MP0010771_integument_phenotype0.91364628
113MP0000465_gastrointestinal_hemorrhage0.91185715
114MP0001243_abnormal_dermal_layer0.90475068
115MP0005636_abnormal_mineral_homeostasis0.88387471
116MP0002572_abnormal_emotion/affect_behav0.88378300
117MP0002733_abnormal_thermal_nociception0.88321129
118MP0002735_abnormal_chemical_nociception0.88271053
119MP0002136_abnormal_kidney_physiology0.88267474
120MP0003936_abnormal_reproductive_system0.88009710
121MP0001188_hyperpigmentation0.87812596
122MP0000609_abnormal_liver_physiology0.87628565
123MP0005423_abnormal_somatic_nervous0.87418377
124MP0000678_abnormal_parathyroid_gland0.86398649
125MP0000049_abnormal_middle_ear0.84232312
126MP0002118_abnormal_lipid_homeostasis0.84197203
127MP0001756_abnormal_urination0.83675212
128MP0002734_abnormal_mechanical_nocicepti0.82915571
129MP0010386_abnormal_urinary_bladder0.82614570
130MP0002210_abnormal_sex_determination0.82333997
131MP0005253_abnormal_eye_physiology0.82187911
132MP0008058_abnormal_DNA_repair0.81978670
133MP0005195_abnormal_posterior_eye0.81200428
134MP0004782_abnormal_surfactant_physiolog0.80893502
135MP0000858_altered_metastatic_potential0.80253569
136MP0001664_abnormal_digestion0.79617443
137MP0001929_abnormal_gametogenesis0.79102643
138MP0002557_abnormal_social/conspecific_i0.79016458
139MP0005319_abnormal_enzyme/_coenzyme0.78531522
140MP0010368_abnormal_lymphatic_system0.78495261
141MP0003698_abnormal_male_reproductive0.77842750
142MP0004858_abnormal_nervous_system0.76588648
143MP0000470_abnormal_stomach_morphology0.76567745
144MP0002229_neurodegeneration0.76449751
145MP0002295_abnormal_pulmonary_circulatio0.74984939
146MP0003091_abnormal_cell_migration0.73153067
147MP0001533_abnormal_skeleton_physiology0.72987700
148MP0001191_abnormal_skin_condition0.72347668
149MP0000627_abnormal_mammary_gland0.70571299
150MP0009931_abnormal_skin_appearance0.69183549
151MP0002896_abnormal_bone_mineralization0.68271149
152MP0001765_abnormal_ion_homeostasis0.67281153
153MP0003436_decreased_susceptibility_to0.67139859
154MP0009785_altered_susceptibility_to0.67053701
155MP0000427_abnormal_hair_cycle0.65394006
156MP0002282_abnormal_trachea_morphology0.64920666
157MP0000647_abnormal_sebaceous_gland0.64890377
158MP0000566_synostosis0.63783303
159MP0004185_abnormal_adipocyte_glucose0.63198924
160MP0009333_abnormal_splenocyte_physiolog0.60503938
161MP0000598_abnormal_liver_morphology0.59292281
162MP0002933_joint_inflammation0.58610380

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.13092145
2Absent/shortened dynein arms (HP:0200106)6.13092145
3Abnormal respiratory epithelium morphology (HP:0012253)6.09499793
4Abnormal respiratory motile cilium morphology (HP:0005938)6.09499793
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.03616849
6Abnormal respiratory motile cilium physiology (HP:0012261)5.57726426
7Abnormal ciliary motility (HP:0012262)5.55032301
8Rhinitis (HP:0012384)5.05647586
9Chronic bronchitis (HP:0004469)4.79648903
10Ileus (HP:0002595)4.71942854
11Right ventricular cardiomyopathy (HP:0011663)4.37863875
12Pancreatic cysts (HP:0001737)4.23450139
13Pancreatic fibrosis (HP:0100732)4.01443744
14True hermaphroditism (HP:0010459)3.95619930
15Abnormality of midbrain morphology (HP:0002418)3.74141000
16Molar tooth sign on MRI (HP:0002419)3.74141000
17Malnutrition (HP:0004395)3.63266565
18Bronchiectasis (HP:0002110)3.60264684
19Xanthomatosis (HP:0000991)3.41112590
20Cystic liver disease (HP:0006706)3.36646644
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36020903
22Intrahepatic cholestasis (HP:0001406)3.34283269
23Nephronophthisis (HP:0000090)3.23253270
24Fragile nails (HP:0001808)3.22354059
25Flat acetabular roof (HP:0003180)3.13489129
26Atrophic scars (HP:0001075)3.12312449
27Onycholysis (HP:0001806)2.99027147
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.97312862
29Abdominal distention (HP:0003270)2.95630867
30Pendular nystagmus (HP:0012043)2.84487537
31Hypobetalipoproteinemia (HP:0003563)2.83200679
32Tubular atrophy (HP:0000092)2.82237644
33Premature rupture of membranes (HP:0001788)2.79110336
34Abnormality of the renal medulla (HP:0100957)2.74954860
35Decreased circulating renin level (HP:0003351)2.73684514
36Sclerocornea (HP:0000647)2.63864960
37Cupped ribs (HP:0000887)2.62739859
38Type II lissencephaly (HP:0007260)2.59521550
39Vascular calcification (HP:0004934)2.58653369
40Furrowed tongue (HP:0000221)2.55969825
41Vacuolated lymphocytes (HP:0001922)2.55616824
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52544286
43Congenital, generalized hypertrichosis (HP:0004540)2.51669387
44Occipital encephalocele (HP:0002085)2.51191976
45Cardiovascular calcification (HP:0011915)2.50985585
46Congenital stationary night blindness (HP:0007642)2.50714484
47Pustule (HP:0200039)2.48092929
48Abnormality of alanine metabolism (HP:0010916)2.47055635
49Hyperalaninemia (HP:0003348)2.47055635
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47055635
51Abnormal hemoglobin (HP:0011902)2.46843769
52Fat malabsorption (HP:0002630)2.45906135
53Fragile skin (HP:0001030)2.45785281
54Hypolipoproteinemia (HP:0010981)2.44068813
55Milia (HP:0001056)2.43325916
56Congenital ichthyosiform erythroderma (HP:0007431)2.39901462
57Peritonitis (HP:0002586)2.38739756
58Thin bony cortex (HP:0002753)2.38479693
59Abnormal tarsal ossification (HP:0008369)2.36353200
60Cervical subluxation (HP:0003308)2.34760876
61Pili torti (HP:0003777)2.34337271
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32214014
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.31742560
64Chronic hepatic failure (HP:0100626)2.31439977
65Abnormality of proline metabolism (HP:0010907)2.30431166
66Hydroxyprolinuria (HP:0003080)2.30431166
67Protrusio acetabuli (HP:0003179)2.29640105
68Hypoplasia of the uterus (HP:0000013)2.29433205
69Interstitial pulmonary disease (HP:0006530)2.29321005
70Infertility (HP:0000789)2.29099616
71Focal segmental glomerulosclerosis (HP:0000097)2.28119085
72Deep venous thrombosis (HP:0002625)2.27247549
73Nasal polyposis (HP:0100582)2.27079264
74Abnormal cartilage morphology (HP:0002763)2.26164725
75Hypoplasia of the pons (HP:0012110)2.24241872
76Male infertility (HP:0003251)2.19860386
77Plantar hyperkeratosis (HP:0007556)2.19640937
78Concave nail (HP:0001598)2.19427970
79Abnormality of the pons (HP:0007361)2.19262650
80Gastrointestinal dysmotility (HP:0002579)2.19077482
81Abolished electroretinogram (ERG) (HP:0000550)2.18936390
82Abnormality of carpal bone ossification (HP:0006257)2.17151571
83Anencephaly (HP:0002323)2.16738111
84Abnormality of the 2nd finger (HP:0004100)2.16429775
85Stridor (HP:0010307)2.16322650
86Chronic sinusitis (HP:0011109)2.16284862
87Glomerulosclerosis (HP:0000096)2.15658946
88Aplasia/hypoplasia of the uterus (HP:0008684)2.13446381
89Male pseudohermaphroditism (HP:0000037)2.12357174
90Esophageal varix (HP:0002040)2.11412159
91Woolly hair (HP:0002224)2.10178458
92Severe muscular hypotonia (HP:0006829)2.10106358
93Cerebellar dysplasia (HP:0007033)2.09817397
94Congenital hepatic fibrosis (HP:0002612)2.09379639
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08624567
96Hypoalphalipoproteinemia (HP:0003233)2.08494228
97Abnormality of renin-angiotensin system (HP:0000847)2.08274269
98Abnormality of the distal phalanges of the toes (HP:0010182)2.07549908
99Protuberant abdomen (HP:0001538)2.07418252
100Micronodular cirrhosis (HP:0001413)2.07364788
101Abnormality of the renal cortex (HP:0011035)2.06077760
102Postaxial foot polydactyly (HP:0001830)2.06062866
103Clumsiness (HP:0002312)2.05275709
104Pterygium (HP:0001059)2.04367423
105Decreased central vision (HP:0007663)2.00660169
106Hyperammonemia (HP:0001987)1.99316608
107Abnormal foot bone ossification (HP:0010675)1.98868834
108Alopecia of scalp (HP:0002293)1.97277978
109Parakeratosis (HP:0001036)1.96390815
110Hyperactive renin-angiotensin system (HP:0000841)1.95609411
111Abnormal vertebral ossification (HP:0100569)1.94966795
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93739624
113Neonatal short-limb short stature (HP:0008921)1.93708835
114Delayed epiphyseal ossification (HP:0002663)1.91068810
115Bronchitis (HP:0012387)1.90736858
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.90702015
117Abnormal rod and cone electroretinograms (HP:0008323)1.90145083
118Preaxial hand polydactyly (HP:0001177)1.89168197
119Medial flaring of the eyebrow (HP:0010747)1.88799450
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87604982
121Beaking of vertebral bodies (HP:0004568)1.87422010
122Trismus (HP:0000211)1.86328315
123Abnormality of purine metabolism (HP:0004352)1.84963667
124Microretrognathia (HP:0000308)1.84667149
125Ulnar bowing (HP:0003031)1.83151162
126Attenuation of retinal blood vessels (HP:0007843)1.82038947
127Proximal tubulopathy (HP:0000114)1.81939137
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.81320674
129Osteolytic defects of the hand bones (HP:0009699)1.81320674
130Abnormality of fatty-acid metabolism (HP:0004359)1.80480603
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.79628401
132Abnormal drinking behavior (HP:0030082)1.79360607
133Polydipsia (HP:0001959)1.79360607
134Glycosuria (HP:0003076)1.79108590
135Abnormality of urine glucose concentration (HP:0011016)1.79108590
136Axonal loss (HP:0003447)1.78753191
137Abnormal ossification of hand bones (HP:0005921)1.77515683
138Aplasia/Hypoplasia of the patella (HP:0006498)1.77400652
139Metabolic alkalosis (HP:0200114)1.77272318
140Nail dystrophy (HP:0008404)1.77219433
141Hypercholesterolemia (HP:0003124)1.77164189
142Dehydration (HP:0001944)1.76571431
143Short nail (HP:0001799)1.76460816
144Nonimmune hydrops fetalis (HP:0001790)1.74904669
145Hyperparathyroidism (HP:0000843)1.74621573
146Renal salt wasting (HP:0000127)1.74440705
147Patellar aplasia (HP:0006443)1.72854756
148Increased CSF lactate (HP:0002490)1.71319037
149Birth length less than 3rd percentile (HP:0003561)1.71264380
150Conjugated hyperbilirubinemia (HP:0002908)1.70681847
151Bony spicule pigmentary retinopathy (HP:0007737)1.70667613
152Abnormality of chloride homeostasis (HP:0011422)1.70512599
153Rickets (HP:0002748)1.70422122
154Amelogenesis imperfecta (HP:0000705)1.70237169
155Increased corneal curvature (HP:0100692)1.69347291
156Keratoconus (HP:0000563)1.69347291
157Increased mean platelet volume (HP:0011877)1.69313560
158Hyperlipoproteinemia (HP:0010980)1.67503467
159Large for gestational age (HP:0001520)1.66907846
160Genetic anticipation (HP:0003743)1.66788024
161Abnormal albumin level (HP:0012116)1.66702497
162Hypoalbuminemia (HP:0003073)1.66702497
163Mitochondrial inheritance (HP:0001427)1.66529197
164Hyperaldosteronism (HP:0000859)1.65360129
165Pigmentary retinal degeneration (HP:0001146)1.65345931
166Steatorrhea (HP:0002570)1.65185816
167Mesangial abnormality (HP:0001966)1.65098851
168Abnormalities of placenta or umbilical cord (HP:0001194)1.64641310
169Cone-rod dystrophy (HP:0000548)1.63126250
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.61192734
171Coxa vara (HP:0002812)1.60901155
172Abnormal enzyme/coenzyme activity (HP:0012379)1.60329049
173Asplenia (HP:0001746)1.59783030
174Aortic aneurysm (HP:0004942)1.58822730
175Aortic dissection (HP:0002647)1.58745517
176Abnormality of the costochondral junction (HP:0000919)1.58694566
177Abnormal number of erythroid precursors (HP:0012131)1.58682446
178Abnormal hair laboratory examination (HP:0003328)1.58240316
179Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.58161377
180Bilateral microphthalmos (HP:0007633)1.57958441
181Amniotic constriction ring (HP:0009775)1.57574703
182Acute necrotizing encephalopathy (HP:0006965)1.57099815
183Abnormality of the nasal mucosa (HP:0000433)1.56108300
184Alkalosis (HP:0001948)1.54739555
185Progressive inability to walk (HP:0002505)1.52166779
186Hepatocellular necrosis (HP:0001404)1.51590800
187Inability to walk (HP:0002540)1.51563986
188Retinitis pigmentosa (HP:0000510)1.51545417
189Chronic otitis media (HP:0000389)1.50261885
190Lissencephaly (HP:0001339)1.49547328
191Sparse eyelashes (HP:0000653)1.49103593
192Methylmalonic aciduria (HP:0012120)1.47706454
193Gait imbalance (HP:0002141)1.47360317
194Delayed CNS myelination (HP:0002188)1.45981555
195Broad-based gait (HP:0002136)1.45954773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.19816755
2EPHA23.65303596
3MAPK153.42582816
4MET3.08259972
5MST43.07682859
6MAP2K22.96006942
7VRK22.64329392
8NME22.47304498
9TLK12.40235622
10PBK2.38503108
11ERN12.37797378
12MAP3K22.36100890
13TESK12.29073087
14EPHB12.09056794
15ADRBK22.06889999
16TESK22.06112159
17PIK3CA2.03939401
18EPHB22.02310201
19MAP3K31.92193166
20BMPR1B1.91890798
21ZAK1.89947560
22PIM21.89900696
23LRRK21.89164849
24LIMK11.84662263
25STK391.78274130
26FRK1.69166688
27BCKDK1.58865282
28DDR21.56047861
29RPS6KB21.51165473
30STK101.49837832
31PTK61.48288342
32PRKG21.38673055
33MAP2K11.36337710
34KSR21.35111267
35MAP3K81.34385686
36PTK21.30962466
37TRIB31.27872210
38TAF11.25990329
39FER1.20642382
40PAK41.19702434
41KDR1.19245876
42OXSR11.17445552
43LMTK21.13967368
44NME11.13893247
45LATS11.13667130
46RIPK11.12807527
47SIK11.11859025
48INSRR1.10680474
49PKN21.09297914
50MAP3K111.06186090
51MAP4K21.04648847
52WNK41.04230523
53PHKG21.04088010
54PHKG11.04088010
55EEF2K1.03958900
56BUB11.03434869
57DYRK21.02002285
58TSSK61.00815460
59CASK1.00078193
60MUSK0.99758638
61BRSK20.97370832
62MAP2K30.96904069
63TTN0.96635260
64MAPKAPK30.93444373
65RPS6KA40.91492687
66TBK10.90096452
67ADRBK10.89429344
68MAPKAPK50.88703563
69TRPM70.85506235
70SMG10.84213420
71STK160.81103640
72BMX0.78471757
73ABL20.78298419
74CSNK1G30.77083571
75ARAF0.76534378
76FGFR40.76142270
77WNK30.76028983
78PAK20.75380622
79ERBB40.75306139
80PLK10.74655700
81MATK0.74117326
82CHEK20.72122785
83TGFBR10.71880642
84TRIM280.71483976
85NEK90.70287301
86ERBB20.70170913
87PAK10.69107026
88CSNK1A1L0.68597566
89PINK10.68049134
90PRKCE0.67793239
91CSNK1G20.67363789
92NEK20.67328840
93VRK10.66728653
94STK38L0.65583608
95CSNK1G10.64213872
96MAP3K10.63846638
97TGFBR20.60420754
98MOS0.60242964
99PTK2B0.59411483
100EIF2AK30.58818674
101TAOK10.56611754
102AURKA0.55528283
103DAPK10.52928733
104PRKCI0.52356852
105SCYL20.52091698
106MAP3K100.51431211
107MAPK130.50642498
108MYLK0.49612319
109CSNK1A10.49467225
110WEE10.49387982
111PAK30.49274990
112NUAK10.49168969
113MAP3K120.49135299
114STK30.48535541
115BRSK10.46787675
116NEK60.45002017
117PIK3CG0.43146045
118DAPK20.42386605
119ILK0.41678088
120GRK50.40862602
121MAP2K60.40329315
122PLK30.40281897
123CHUK0.38178272
124MAPKAPK20.38147425
125FLT30.37494106
126EIF2AK10.37450117
127IRAK10.37255143
128FGFR20.37003184
129CDK60.36672722
130CAMK2D0.35862571
131ROCK20.35577771
132ATR0.35401880
133MELK0.35322242
134BLK0.34799355
135CAMK2G0.33237715
136EPHA30.33185395
137PRKCG0.32887371
138CAMK2A0.32134036
139AURKB0.31757457
140CDK80.31645131
141RET0.31346473
142ACVR1B0.31184311
143GRK10.30900141
144ROCK10.30840301
145PDK20.30508130
146BCR0.29381812
147TNIK0.28999785
148RPS6KA50.28965063
149STK380.28920088
150MKNK20.28695060
151GSK3A0.28290599
152CDK190.28281839
153HIPK20.28183388
154TYK20.28010105
155TTK0.27730388
156PDGFRA0.26645872
157IKBKB0.26099366
158LATS20.25801785

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.43640830
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95556977
3Fat digestion and absorption_Homo sapiens_hsa049752.62261127
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54293298
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40416153
6Mineral absorption_Homo sapiens_hsa049782.38588492
7Glutathione metabolism_Homo sapiens_hsa004802.26259614
8Steroid biosynthesis_Homo sapiens_hsa001002.08288040
9Folate biosynthesis_Homo sapiens_hsa007902.05162705
10RNA polymerase_Homo sapiens_hsa030202.01514763
11Histidine metabolism_Homo sapiens_hsa003402.01189272
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92394865
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88766110
14Phototransduction_Homo sapiens_hsa047441.84926271
15Vitamin digestion and absorption_Homo sapiens_hsa049771.84330751
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84095906
17Caffeine metabolism_Homo sapiens_hsa002321.81466882
18Oxidative phosphorylation_Homo sapiens_hsa001901.78027815
19Chemical carcinogenesis_Homo sapiens_hsa052041.74096475
20Huntingtons disease_Homo sapiens_hsa050161.72022172
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65874113
22Fatty acid elongation_Homo sapiens_hsa000621.65285605
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61431669
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61163334
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61068708
26Fatty acid degradation_Homo sapiens_hsa000711.59610851
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59214516
28Homologous recombination_Homo sapiens_hsa034401.55473508
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.51091015
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49153908
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46314084
32Tryptophan metabolism_Homo sapiens_hsa003801.46108233
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44938996
34Sulfur relay system_Homo sapiens_hsa041221.42696830
35Nitrogen metabolism_Homo sapiens_hsa009101.40363932
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40251426
37Pentose phosphate pathway_Homo sapiens_hsa000301.39962639
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38339786
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.37389024
40Renin-angiotensin system_Homo sapiens_hsa046141.34616016
41Ribosome_Homo sapiens_hsa030101.28564023
42Arginine and proline metabolism_Homo sapiens_hsa003301.27466988
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26633806
44Bladder cancer_Homo sapiens_hsa052191.26538473
45Retinol metabolism_Homo sapiens_hsa008301.25175380
46Peroxisome_Homo sapiens_hsa041461.24233313
47Parkinsons disease_Homo sapiens_hsa050121.23674078
48Pyrimidine metabolism_Homo sapiens_hsa002401.20610434
49Basal transcription factors_Homo sapiens_hsa030221.20209666
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17569221
51PPAR signaling pathway_Homo sapiens_hsa033201.17451650
52Bile secretion_Homo sapiens_hsa049761.16977143
53Starch and sucrose metabolism_Homo sapiens_hsa005001.16498908
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.15143712
55Arginine biosynthesis_Homo sapiens_hsa002201.14734313
56Galactose metabolism_Homo sapiens_hsa000521.14575579
57Taste transduction_Homo sapiens_hsa047421.11882990
58Nicotine addiction_Homo sapiens_hsa050331.09767965
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04795755
60Carbon metabolism_Homo sapiens_hsa012001.04062030
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03882754
62Protein digestion and absorption_Homo sapiens_hsa049741.03684205
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03452276
64Alzheimers disease_Homo sapiens_hsa050101.01374172
65Fanconi anemia pathway_Homo sapiens_hsa034600.99901113
66Fructose and mannose metabolism_Homo sapiens_hsa000510.98985028
67One carbon pool by folate_Homo sapiens_hsa006700.98158954
68Pyruvate metabolism_Homo sapiens_hsa006200.98082728
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98080620
70ABC transporters_Homo sapiens_hsa020100.97678622
71Tight junction_Homo sapiens_hsa045300.97581552
72Fatty acid metabolism_Homo sapiens_hsa012120.97571276
73Butanoate metabolism_Homo sapiens_hsa006500.95735769
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95109790
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.92992030
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92939785
77Selenocompound metabolism_Homo sapiens_hsa004500.92904267
78Biosynthesis of amino acids_Homo sapiens_hsa012300.91049279
79Sphingolipid metabolism_Homo sapiens_hsa006000.90315342
80Linoleic acid metabolism_Homo sapiens_hsa005910.89241072
81ECM-receptor interaction_Homo sapiens_hsa045120.89193652
82Purine metabolism_Homo sapiens_hsa002300.88165813
83beta-Alanine metabolism_Homo sapiens_hsa004100.88009966
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86120814
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.83926301
86Arachidonic acid metabolism_Homo sapiens_hsa005900.83616864
87Thyroid cancer_Homo sapiens_hsa052160.81523675
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81411235
89Glycerolipid metabolism_Homo sapiens_hsa005610.79387018
90Proteasome_Homo sapiens_hsa030500.78355920
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.77449777
92Complement and coagulation cascades_Homo sapiens_hsa046100.77193670
93Shigellosis_Homo sapiens_hsa051310.76765506
94Vitamin B6 metabolism_Homo sapiens_hsa007500.75213948
95Cardiac muscle contraction_Homo sapiens_hsa042600.72824530
96Salivary secretion_Homo sapiens_hsa049700.68472148
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.67998824
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67173968
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66367379
100Adherens junction_Homo sapiens_hsa045200.66130528
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65703574
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65575179
103Ether lipid metabolism_Homo sapiens_hsa005650.65093190
104Propanoate metabolism_Homo sapiens_hsa006400.64223261
105Nucleotide excision repair_Homo sapiens_hsa034200.62185597
106Salmonella infection_Homo sapiens_hsa051320.61035192
107Olfactory transduction_Homo sapiens_hsa047400.59073229
108Base excision repair_Homo sapiens_hsa034100.57594120
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57474541
110Lysosome_Homo sapiens_hsa041420.56647582
111Insulin secretion_Homo sapiens_hsa049110.56525285
112Ovarian steroidogenesis_Homo sapiens_hsa049130.56080957
113RNA degradation_Homo sapiens_hsa030180.55645363
114Phenylalanine metabolism_Homo sapiens_hsa003600.54694920
115Metabolic pathways_Homo sapiens_hsa011000.54662984
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.53505532
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53314439
118Other glycan degradation_Homo sapiens_hsa005110.52318572
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51580353
120Tyrosine metabolism_Homo sapiens_hsa003500.51532504
121Hepatitis C_Homo sapiens_hsa051600.50566776
122Proteoglycans in cancer_Homo sapiens_hsa052050.50266781
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48380407
124Fatty acid biosynthesis_Homo sapiens_hsa000610.48332200
125Regulation of autophagy_Homo sapiens_hsa041400.45789640
126Pertussis_Homo sapiens_hsa051330.45536806
127Vibrio cholerae infection_Homo sapiens_hsa051100.44295417
128Collecting duct acid secretion_Homo sapiens_hsa049660.42764348
129Serotonergic synapse_Homo sapiens_hsa047260.42258777
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40948366
131Mismatch repair_Homo sapiens_hsa034300.40947393
132N-Glycan biosynthesis_Homo sapiens_hsa005100.39839400
133Basal cell carcinoma_Homo sapiens_hsa052170.39441202
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38991844
135Small cell lung cancer_Homo sapiens_hsa052220.37569543
136Focal adhesion_Homo sapiens_hsa045100.36997571
137Hippo signaling pathway_Homo sapiens_hsa043900.36681881
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33922525
139Protein export_Homo sapiens_hsa030600.33682554
140Amoebiasis_Homo sapiens_hsa051460.31722547
141Apoptosis_Homo sapiens_hsa042100.31111608
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30893060

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