PLPP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)7.59443196
2startle response (GO:0001964)6.66731324
3vocalization behavior (GO:0071625)6.66035126
4postsynaptic membrane organization (GO:0001941)6.36519675
5presynaptic membrane assembly (GO:0097105)6.20682040
6locomotory exploration behavior (GO:0035641)6.05196595
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.03097128
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.51756612
9regulation of glutamate receptor signaling pathway (GO:1900449)5.48560972
10presynaptic membrane organization (GO:0097090)5.31522764
11positive regulation of synapse assembly (GO:0051965)5.08794785
12regulation of penile erection (GO:0060405)4.96120270
13protein maturation by protein folding (GO:0022417)4.92377919
14endodermal cell differentiation (GO:0035987)4.85367818
15neurotransmitter-gated ion channel clustering (GO:0072578)4.84348494
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.82135895
17substrate-dependent cell migration (GO:0006929)4.79514599
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.70390753
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59381751
20cell adhesion mediated by integrin (GO:0033627)4.46855202
21exploration behavior (GO:0035640)4.45874688
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38865497
23regulation of synaptic transmission, glutamatergic (GO:0051966)4.21745707
24negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.21132817
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.21122652
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.13065528
27neurotransmitter secretion (GO:0007269)4.06314761
28extracellular fibril organization (GO:0043206)4.04672374
29negative regulation of chondrocyte differentiation (GO:0032331)4.01838875
30chondrocyte proliferation (GO:0035988)3.98330082
31sequestering of extracellular ligand from receptor (GO:0035581)3.98242475
32bone trabecula formation (GO:0060346)3.95058799
33long-term synaptic potentiation (GO:0060291)3.94533119
34protein localization to synapse (GO:0035418)3.93019626
35protein retention in ER lumen (GO:0006621)3.92698293
36positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.91797856
37glutamate receptor signaling pathway (GO:0007215)3.91334843
38ventricular cardiac muscle cell development (GO:0055015)3.89515229
39mesodermal cell differentiation (GO:0048333)3.88430304
40cerebellar granule cell differentiation (GO:0021707)3.85963875
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.79767173
42endocardial cushion development (GO:0003197)3.79559128
43neuron-neuron synaptic transmission (GO:0007270)3.79031933
44positive regulation of synapse maturation (GO:0090129)3.75468098
45actin filament depolymerization (GO:0030042)3.75097582
46transmission of nerve impulse (GO:0019226)3.74966293
47Golgi transport vesicle coating (GO:0048200)3.71922828
48COPI coating of Golgi vesicle (GO:0048205)3.71922828
49regulation of female receptivity (GO:0045924)3.70484405
50regulation of synapse assembly (GO:0051963)3.69468902
51synaptic transmission, glutamatergic (GO:0035249)3.67229818
52gamma-aminobutyric acid transport (GO:0015812)3.66444399
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.64620552
54protein localization to endosome (GO:0036010)3.61093298
55neuron recognition (GO:0008038)3.58388922
56aggressive behavior (GO:0002118)3.58104496
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58049851
58wound healing, spreading of epidermal cells (GO:0035313)3.54912636
59female mating behavior (GO:0060180)3.54658931
60regulation of synaptic vesicle exocytosis (GO:2000300)3.54460474
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.52614610
62behavioral defense response (GO:0002209)3.49795161
63behavioral fear response (GO:0001662)3.49795161
64regulation of synapse maturation (GO:0090128)3.47577303
65collagen fibril organization (GO:0030199)3.47223146
66negative regulation of dendrite morphogenesis (GO:0050774)3.46689934
67peptidyl-proline hydroxylation (GO:0019511)3.45778774
68positive regulation of actin filament depolymerization (GO:0030836)3.44094007
69regulation of synaptic transmission, GABAergic (GO:0032228)3.43877229
70fat-soluble vitamin catabolic process (GO:0042363)3.42656037
71vitamin catabolic process (GO:0009111)3.42656037
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.39680370
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39032982
74negative regulation of axon extension involved in axon guidance (GO:0048843)3.36550217
75auditory behavior (GO:0031223)3.35700785
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32749983
77SMAD protein complex assembly (GO:0007183)3.30606027
78negative regulation of dendrite development (GO:2000171)3.29871381
79skin morphogenesis (GO:0043589)3.28764392
80neurotransmitter transport (GO:0006836)3.27679036
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26297799
82proline transport (GO:0015824)3.25284275
83regulation of synaptic vesicle transport (GO:1902803)3.25133343
84regulation of respiratory system process (GO:0044065)3.24665131
85regulation of glutamate secretion (GO:0014048)3.24365077
86positive regulation of axon extension (GO:0045773)3.23265935
87long-term memory (GO:0007616)3.22495845
88synapse assembly (GO:0007416)3.22080246
89transferrin transport (GO:0033572)3.20680800
90response to gravity (GO:0009629)3.19734015
91righting reflex (GO:0060013)3.19301327
92response to histamine (GO:0034776)3.19068344
93positive regulation of synaptic transmission (GO:0050806)3.17763524
94neuronal action potential propagation (GO:0019227)3.17449652
95fibril organization (GO:0097435)3.16873375
96synaptic vesicle exocytosis (GO:0016079)3.16517218
97positive regulation of osteoblast proliferation (GO:0033690)3.11943117
98regulation of neurotransmitter levels (GO:0001505)3.11401569
99neuron projection extension involved in neuron projection guidance (GO:1902284)3.11291080
100axon extension involved in axon guidance (GO:0048846)3.11291080
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09422882
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08960325
103ATP hydrolysis coupled proton transport (GO:0015991)3.08960325
104muscle cell migration (GO:0014812)3.08943027
105membrane raft organization (GO:0031579)3.08823325
106kidney mesenchyme development (GO:0072074)3.08583241
107fear response (GO:0042596)3.06987628
108mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.05955393
109cellular response to ammonium ion (GO:0071242)3.04869457
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04246258
111succinate metabolic process (GO:0006105)3.02297109
112positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.02162725
113glutamate secretion (GO:0014047)3.01568375
114endothelial cell proliferation (GO:0001935)3.00693010
115regulation of synapse organization (GO:0050807)2.99698157
116cellular response to vitamin (GO:0071295)2.99248859
117cellular response to vitamin D (GO:0071305)2.98843451
118membrane assembly (GO:0071709)2.98832935
119retina vasculature morphogenesis in camera-type eye (GO:0061299)2.98614906
120protein hydroxylation (GO:0018126)2.98602180
121ferric iron transport (GO:0015682)2.97496213
122trivalent inorganic cation transport (GO:0072512)2.97496213
123positive regulation of membrane potential (GO:0045838)2.97002560
124ganglion development (GO:0061548)2.96686849
125negative regulation of amino acid transport (GO:0051956)2.95058868
126positive regulation of amino acid transport (GO:0051957)2.92961759
127innervation (GO:0060384)2.91203953
128neurotransmitter biosynthetic process (GO:0042136)2.89623372
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89427449
130sensory perception of pain (GO:0019233)2.89373457
131negative regulation of synaptic transmission (GO:0050805)2.88360585
132negative regulation of cartilage development (GO:0061037)2.87803939
133cell migration involved in sprouting angiogenesis (GO:0002042)2.87265119
134learning (GO:0007612)2.87087582
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86937589
136mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.86684694
137short-term memory (GO:0007614)2.86605871
138striatum development (GO:0021756)2.86559403
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.85966568
140regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85125047
141barbed-end actin filament capping (GO:0051016)2.84716363
142intraspecies interaction between organisms (GO:0051703)2.84696549
143social behavior (GO:0035176)2.84696549
144response to cocaine (GO:0042220)2.84626481
145regulation of cardioblast differentiation (GO:0051890)2.83353728
146regulation of respiratory gaseous exchange (GO:0043576)2.83079532
147gonadal mesoderm development (GO:0007506)2.82552211
148membrane hyperpolarization (GO:0060081)2.80787915
149synaptic vesicle maturation (GO:0016188)2.80351624
150cerebellar Purkinje cell differentiation (GO:0021702)2.80342924
151negative regulation of activin receptor signaling pathway (GO:0032926)2.79951889
152wound healing, spreading of cells (GO:0044319)2.79307675
153negative regulation of BMP signaling pathway (GO:0030514)2.78231090
154regulation of axon extension involved in axon guidance (GO:0048841)2.76025757
155extracellular matrix assembly (GO:0085029)2.74475465
156vascular endothelial growth factor signaling pathway (GO:0038084)2.73082702
157cortical actin cytoskeleton organization (GO:0030866)2.70979986
158positive regulation of protein autophosphorylation (GO:0031954)2.70015293
159type B pancreatic cell proliferation (GO:0044342)2.67328079
160lipopolysaccharide biosynthetic process (GO:0009103)2.66473416
161negative regulation of osteoblast proliferation (GO:0033689)2.66279881
162mitotic nuclear envelope reassembly (GO:0007084)2.65383733
163nuclear envelope reassembly (GO:0031468)2.65383733
164negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63020418
165heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.61826075
166negative regulation of stem cell proliferation (GO:2000647)2.61783400
167negative regulation of embryonic development (GO:0045992)2.61723723
168apoptotic cell clearance (GO:0043277)2.61661093
169positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.61394248
170substrate adhesion-dependent cell spreading (GO:0034446)2.60942372
171glomerular visceral epithelial cell development (GO:0072015)2.56849173
172cell migration involved in gastrulation (GO:0042074)2.56061983
173positive regulation of gastrulation (GO:2000543)2.55744418
174negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.55351420
175extracellular negative regulation of signal transduction (GO:1900116)2.55283859
176extracellular regulation of signal transduction (GO:1900115)2.55283859
177craniofacial suture morphogenesis (GO:0097094)2.54842582
178lymphangiogenesis (GO:0001946)2.54721613
179embryonic viscerocranium morphogenesis (GO:0048703)2.52660411
180cortical cytoskeleton organization (GO:0030865)2.52386948
181negative regulation of axon guidance (GO:1902668)2.51490988
182regulation of osteoblast proliferation (GO:0033688)2.51432548
183L-serine transport (GO:0015825)2.51414552
184regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.50381513
185smooth muscle tissue development (GO:0048745)2.50033344
186vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49971781
187positive regulation of endothelial cell migration (GO:0010595)2.49576475
188cell migration involved in heart development (GO:0060973)2.49225923
189lung morphogenesis (GO:0060425)2.48511894
190sprouting angiogenesis (GO:0002040)2.48386604
191cellular response to BMP stimulus (GO:0071773)2.47602886
192response to BMP (GO:0071772)2.47602886
193axon extension (GO:0048675)2.47129568
194pattern specification involved in kidney development (GO:0061004)2.44990157
195establishment of integrated proviral latency (GO:0075713)2.42298668
196positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.41295989
197metanephric mesenchyme development (GO:0072075)2.40937735
198negative regulation of fibroblast apoptotic process (GO:2000270)2.38578485
199regulation of integrin-mediated signaling pathway (GO:2001044)2.38480510
200glial cell migration (GO:0008347)2.37403873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.61214269
2EZH2_22144423_ChIP-Seq_EOC_Human4.94497227
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.68788984
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.03517186
5GBX2_23144817_ChIP-Seq_PC3_Human3.94604163
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.61565516
7TAF15_26573619_Chip-Seq_HEK293_Human3.17658780
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10632358
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10019757
10JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06961474
11BRD4_25478319_ChIP-Seq_HGPS_Human2.85909693
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78951086
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72289370
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.66781500
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.66411955
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63595926
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61175252
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.59411044
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58366442
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58366442
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57903978
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56615040
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56273788
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55029621
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46527508
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.46340654
27ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.45760404
28AR_21572438_ChIP-Seq_LNCaP_Human2.44443048
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40494990
30WT1_19549856_ChIP-ChIP_CCG9911_Human2.39069022
31CJUN_26792858_Chip-Seq_BT549_Human2.30828310
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29794116
33MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28888459
34IGF1R_20145208_ChIP-Seq_DFB_Human2.25052665
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24270242
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23753342
37CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21795392
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.19828596
39EZH2_27294783_Chip-Seq_ESCs_Mouse2.18184564
40HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17792460
41REST_21632747_ChIP-Seq_MESCs_Mouse2.15665536
42SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13489859
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11454111
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06728683
45RNF2_27304074_Chip-Seq_ESCs_Mouse2.05201475
46AR_21909140_ChIP-Seq_LNCAP_Human2.01276357
47FOXM1_23109430_ChIP-Seq_U2OS_Human2.01164127
48CLOCK_20551151_ChIP-Seq_293T_Human1.94921298
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92391521
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.91286910
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.88720031
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87048982
53SMAD4_21799915_ChIP-Seq_A2780_Human1.85646779
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.84116487
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.81643849
56P300_19829295_ChIP-Seq_ESCs_Human1.79859905
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76912074
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75726279
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.75504754
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73854796
61EOMES_21245162_ChIP-Seq_HESCs_Human1.73538583
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72566717
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72206250
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71891649
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71891649
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71838337
67RNF2_27304074_Chip-Seq_NSC_Mouse1.71472450
68TP53_18474530_ChIP-ChIP_U2OS_Human1.67809465
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.67727221
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67455387
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66200476
72FUS_26573619_Chip-Seq_HEK293_Human1.65996961
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63986973
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63923316
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63605047
76ER_23166858_ChIP-Seq_MCF-7_Human1.62907580
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60776131
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59279337
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59253765
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.59076778
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58073540
82VDR_22108803_ChIP-Seq_LS180_Human1.57553861
83DROSHA_22980978_ChIP-Seq_HELA_Human1.55961991
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55280552
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53690760
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53044858
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53042519
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.48914043
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.48576780
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.48129217
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48071461
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47920781
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44538718
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43871422
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.42223392
96AR_25329375_ChIP-Seq_VCAP_Human1.41741637
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41628937
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.41242036
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40317230
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39964422
101TP53_22127205_ChIP-Seq_IMR90_Human1.37282867
102ZNF274_21170338_ChIP-Seq_K562_Hela1.36460469
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36185326
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.34896722
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.34816929
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34152597
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33500330
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33421754
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33224290
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.31092050
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29414931
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28732255
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28598251
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28045622
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.27453401
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26764651
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26719821
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26719821
119AHR_22903824_ChIP-Seq_MCF-7_Human1.26160606
120SA1_22415368_ChIP-Seq_MEFs_Mouse1.25057240
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24669762
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24438419
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24190505
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23958906
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18625415
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18625415
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18625415
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18096243
129STAT3_23295773_ChIP-Seq_U87_Human1.17431630
130E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16666001
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16492015
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15533675
133TP53_23651856_ChIP-Seq_MEFs_Mouse1.14531906
134NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14147404
135ATF3_27146783_Chip-Seq_COLON_Human1.13606741
136PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12846540
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.12798058
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12519815
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12519815
140ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11814738
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11657878
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11456807
143TP53_20018659_ChIP-ChIP_R1E_Mouse1.11452348
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11429763
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11305721
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11176849
147FLI1_27457419_Chip-Seq_LIVER_Mouse1.11031383
148THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10889437
149JUN_21703547_ChIP-Seq_K562_Human1.10684509
150TCF4_23295773_ChIP-Seq_U87_Human1.10572343
151TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10290009
152RUNX2_22187159_ChIP-Seq_PCA_Human1.10275773
153NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09890173
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09232162
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07233461
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04689538
157NANOG_18555785_Chip-Seq_ESCs_Mouse1.04614378
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03583764
159IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03325409
160TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03227660
161RING1B_27294783_Chip-Seq_NPCs_Mouse1.02771282
162AR_19668381_ChIP-Seq_PC3_Human1.01838820
163PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00978772
164BCAT_22108803_ChIP-Seq_LS180_Human1.00776356
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00113953
166TCF4_18268006_ChIP-ChIP_LS174T_Human0.98744283
167TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98163242
168MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98096331
169ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98019534
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97973109
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95918365
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95746916
173SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95177301
174KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95064758
175SMAD_19615063_ChIP-ChIP_OVARY_Human0.94822877
176NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94582652
177SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94143573
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.93720019
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93411087
180SMAD3_21741376_ChIP-Seq_ESCs_Human0.92198633
181TP53_16413492_ChIP-PET_HCT116_Human0.91938471
182GABP_17652178_ChIP-ChIP_JURKAT_Human0.90664204
183EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90478462
184TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90381560
185MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90353816
186KDM2B_26808549_Chip-Seq_REH_Human0.90137137
187TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89846726
188KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88725782
189SOX9_26525672_Chip-Seq_HEART_Mouse0.88708692
190E2F1_18555785_Chip-Seq_ESCs_Mouse0.88450444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.81810716
2MP0010030_abnormal_orbit_morphology4.48354773
3MP0003880_abnormal_central_pattern4.38439757
4MP0004859_abnormal_synaptic_plasticity3.89258032
5MP0005257_abnormal_intraocular_pressure3.77147668
6MP0003279_aneurysm3.62283184
7MP0005623_abnormal_meninges_morphology3.54547141
8MP0010368_abnormal_lymphatic_system3.42639113
9MP0003566_abnormal_cell_adhesion3.40623557
10MP0003635_abnormal_synaptic_transmissio3.33886323
11MP0002736_abnormal_nociception_after3.27130580
12MP0002822_catalepsy3.25744025
13MP0009745_abnormal_behavioral_response3.23950785
14MP0004272_abnormal_basement_membrane3.22283205
15MP0003705_abnormal_hypodermis_morpholog3.22045656
16MP0001968_abnormal_touch/_nociception3.19051536
17MP0005646_abnormal_pituitary_gland3.06424049
18MP0003950_abnormal_plasma_membrane3.01152372
19MP0005423_abnormal_somatic_nervous2.98702578
20MP0002063_abnormal_learning/memory/cond2.78474082
21MP0002064_seizures2.77774462
22MP0003122_maternal_imprinting2.69791607
23MP0009046_muscle_twitch2.67026199
24MP0002877_abnormal_melanocyte_morpholog2.61931069
25MP0002735_abnormal_chemical_nociception2.58884162
26MP0002572_abnormal_emotion/affect_behav2.51846895
27MP0006276_abnormal_autonomic_nervous2.51606492
28MP0002272_abnormal_nervous_system2.42098010
29MP0004270_analgesia2.38445276
30MP0001486_abnormal_startle_reflex2.38087955
31MP0002734_abnormal_mechanical_nocicepti2.35366014
32MP0003787_abnormal_imprinting2.32482617
33MP0001529_abnormal_vocalization2.27040256
34MP0005645_abnormal_hypothalamus_physiol2.25546702
35MP0005275_abnormal_skin_tensile2.19726481
36MP0001958_emphysema2.19179666
37MP0006054_spinal_hemorrhage2.15388719
38MP0002184_abnormal_innervation2.08320489
39MP0002067_abnormal_sensory_capabilities2.03580762
40MP0000534_abnormal_ureter_morphology2.03517363
41MP0002733_abnormal_thermal_nociception2.03474229
42MP0001970_abnormal_pain_threshold2.03303091
43MP0001542_abnormal_bone_strength2.00353276
44MP0001188_hyperpigmentation1.97144355
45MP0000749_muscle_degeneration1.89297248
46MP0004142_abnormal_muscle_tone1.87954909
47MP0001984_abnormal_olfaction1.87632644
48MP0003890_abnormal_embryonic-extraembry1.84689962
49MP0002557_abnormal_social/conspecific_i1.83511194
50MP0001440_abnormal_grooming_behavior1.78008587
51MP0003091_abnormal_cell_migration1.73243359
52MP0005023_abnormal_wound_healing1.70925681
53MP0009780_abnormal_chondrocyte_physiolo1.69770524
54MP0001501_abnormal_sleep_pattern1.68282557
55MP0005503_abnormal_tendon_morphology1.65099683
56MP0004858_abnormal_nervous_system1.63171826
57MP0000767_abnormal_smooth_muscle1.61418541
58MP0005171_absent_coat_pigmentation1.60703634
59MP0005508_abnormal_skeleton_morphology1.59569619
60MP0009384_cardiac_valve_regurgitation1.57295694
61MP0000778_abnormal_nervous_system1.55886016
62MP0004742_abnormal_vestibular_system1.54772834
63MP0000762_abnormal_tongue_morphology1.54471758
64MP0001879_abnormal_lymphatic_vessel1.51258888
65MP0002837_dystrophic_cardiac_calcinosis1.49765440
66MP0005197_abnormal_uvea_morphology1.47115607
67MP0000428_abnormal_craniofacial_morphol1.44601058
68MP0000537_abnormal_urethra_morphology1.41333819
69MP0001502_abnormal_circadian_rhythm1.40827718
70MP0004924_abnormal_behavior1.37504688
71MP0005386_behavior/neurological_phenoty1.37504688
72MP0002882_abnormal_neuron_morphology1.33374729
73MP0002295_abnormal_pulmonary_circulatio1.32410969
74MP0002066_abnormal_motor_capabilities/c1.30343015
75MP0001243_abnormal_dermal_layer1.28357980
76MP0003941_abnormal_skin_development1.28269287
77MP0009053_abnormal_anal_canal1.26867808
78MP0000733_abnormal_muscle_development1.26807932
79MP0008569_lethality_at_weaning1.26489196
80MP0002876_abnormal_thyroid_physiology1.26392680
81MP0002060_abnormal_skin_morphology1.25326049
82MP0000955_abnormal_spinal_cord1.24144646
83MP0004811_abnormal_neuron_physiology1.23761932
84MP0002896_abnormal_bone_mineralization1.20771489
85MP0001986_abnormal_taste_sensitivity1.20141838
86MP0003119_abnormal_digestive_system1.18316153
87MP0001905_abnormal_dopamine_level1.17780463
88MP0004885_abnormal_endolymph1.17081440
89MP0004510_myositis1.14006836
90MP0003191_abnormal_cellular_cholesterol1.13082304
91MP0003938_abnormal_ear_development1.12343887
92MP0003329_amyloid_beta_deposits1.11846844
93MP0001963_abnormal_hearing_physiology1.11838865
94MP0003879_abnormal_hair_cell1.11430985
95MP0009250_abnormal_appendicular_skeleto1.09816232
96MP0000026_abnormal_inner_ear1.09128098
97MP0003942_abnormal_urinary_system1.09054816
98MP0008932_abnormal_embryonic_tissue1.06753340
99MP0003121_genomic_imprinting1.06699787
100MP0003283_abnormal_digestive_organ1.06079915
101MP0004085_abnormal_heartbeat1.05645913
102MP0000163_abnormal_cartilage_morphology1.04545165
103MP0010352_gastrointestinal_tract_polyps1.02541565
104MP0002152_abnormal_brain_morphology1.01249355
105MP0002932_abnormal_joint_morphology1.00688967
106MP0005193_abnormal_anterior_eye1.00321644
107MP0005165_increased_susceptibility_to1.00203276
108MP0005058_abnormal_lysosome_morphology1.00133848
109MP0001348_abnormal_lacrimal_gland0.99814451
110MP0000631_abnormal_neuroendocrine_gland0.99355278
111MP0003937_abnormal_limbs/digits/tail_de0.98490977
112MP0002177_abnormal_outer_ear0.98486942
113MP0003183_abnormal_peptide_metabolism0.97154547
114MP0000750_abnormal_muscle_regeneration0.94449664
115MP0003935_abnormal_craniofacial_develop0.93792874
116MP0002752_abnormal_somatic_nervous0.93691910
117MP0003755_abnormal_palate_morphology0.91570619
118MP0003448_altered_tumor_morphology0.90206720
119MP0002108_abnormal_muscle_morphology0.89832792
120MP0000343_altered_response_to0.89170362
121MP0000462_abnormal_digestive_system0.88340265
122MP0000751_myopathy0.87405577
123MP0002638_abnormal_pupillary_reflex0.87402223
124MP0003137_abnormal_impulse_conducting0.86611558
125MP0002332_abnormal_exercise_endurance0.86358106
126MP0001177_atelectasis0.86299880
127MP0005595_abnormal_vascular_smooth0.85791346
128MP0002069_abnormal_eating/drinking_beha0.85763455
129MP0008877_abnormal_DNA_methylation0.85053488
130MP0002751_abnormal_autonomic_nervous0.84815637
131MP0003123_paternal_imprinting0.83587636
132MP0001664_abnormal_digestion0.83305865
133MP0004215_abnormal_myocardial_fiber0.82724944
134MP0003632_abnormal_nervous_system0.82492229
135MP0005551_abnormal_eye_electrophysiolog0.80234472
136MP0003631_nervous_system_phenotype0.79472739
137MP0002084_abnormal_developmental_patter0.78987791
138MP0000432_abnormal_head_morphology0.78243766
139MP0003634_abnormal_glial_cell0.77061458
140MP0009840_abnormal_foam_cell0.75856458
141MP0000759_abnormal_skeletal_muscle0.75317971
142MP0002909_abnormal_adrenal_gland0.75151277
143MP0002282_abnormal_trachea_morphology0.74102313
144MP0002234_abnormal_pharynx_morphology0.73902752
145MP0002229_neurodegeneration0.73552753
146MP0002085_abnormal_embryonic_tissue0.72866530
147MP0005621_abnormal_cell_physiology0.72689409
148MP0001943_abnormal_respiration0.72541851
149MP0003633_abnormal_nervous_system0.71248528
150MP0003385_abnormal_body_wall0.71166423
151MP0000049_abnormal_middle_ear0.70896671
152MP0001270_distended_abdomen0.70809457
153MP0001672_abnormal_embryogenesis/_devel0.70757672
154MP0005380_embryogenesis_phenotype0.70757672
155MP0002114_abnormal_axial_skeleton0.70729365
156MP0005499_abnormal_olfactory_system0.70555651
157MP0005394_taste/olfaction_phenotype0.70555651
158MP0002116_abnormal_craniofacial_bone0.70114342
159MP0002113_abnormal_skeleton_development0.69496716
160MP0002925_abnormal_cardiovascular_devel0.69337757
161MP0000013_abnormal_adipose_tissue0.69005676
162MP0001614_abnormal_blood_vessel0.68400001
163MP0002233_abnormal_nose_morphology0.68368749
164MP0001340_abnormal_eyelid_morphology0.67138593
165MP0001299_abnormal_eye_distance/0.66594057
166MP0010386_abnormal_urinary_bladder0.66339127
167MP0002249_abnormal_larynx_morphology0.65510626
168MP0002102_abnormal_ear_morphology0.64119854
169MP0005535_abnormal_body_temperature0.63727878
170MP0003718_maternal_effect0.62567579
171MP0010770_preweaning_lethality0.62513320
172MP0002082_postnatal_lethality0.62513320
173MP0005647_abnormal_sex_gland0.62381592
174MP0002128_abnormal_blood_circulation0.62000819
175MP0000516_abnormal_urinary_system0.60212242
176MP0005367_renal/urinary_system_phenotyp0.60212242
177MP0001915_intracranial_hemorrhage0.59310160
178MP0000358_abnormal_cell_content/0.58037448
179MP0005390_skeleton_phenotype0.55912596
180MP0002109_abnormal_limb_morphology0.55210806
181MP0003984_embryonic_growth_retardation0.55002844
182MP0002115_abnormal_skeleton_extremities0.54941474
183MP0005384_cellular_phenotype0.53296986
184MP0005330_cardiomyopathy0.52314833
185MP0003186_abnormal_redox_activity0.52145788
186MP0000747_muscle_weakness0.51984028

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.51211995
2Hyperventilation (HP:0002883)7.39829994
3Focal motor seizures (HP:0011153)6.55015340
4Protrusio acetabuli (HP:0003179)6.07504341
5Epileptic encephalopathy (HP:0200134)4.87661414
6Atonic seizures (HP:0010819)4.78459142
7Febrile seizures (HP:0002373)4.78350088
8Myokymia (HP:0002411)4.44883549
9Vertebral compression fractures (HP:0002953)4.38872906
10Focal seizures (HP:0007359)4.27695316
11Aortic dissection (HP:0002647)4.20126998
12Neoplasm of the peripheral nervous system (HP:0100007)4.19431487
13Pheochromocytoma (HP:0002666)4.18109419
14Neuroendocrine neoplasm (HP:0100634)3.95108141
15Ankle contracture (HP:0006466)3.87987520
16Cervical subluxation (HP:0003308)3.76600827
17Polyphagia (HP:0002591)3.66407427
18Vascular tortuosity (HP:0004948)3.62105238
19Arterial tortuosity (HP:0005116)3.53674747
20Progressive inability to walk (HP:0002505)3.44020993
21Broad-based gait (HP:0002136)3.43062419
22Limb dystonia (HP:0002451)3.39029890
23Atrophic scars (HP:0001075)3.35208919
24Abnormal umbilical cord blood vessels (HP:0011403)3.29342241
25Single umbilical artery (HP:0001195)3.29342241
26Abnormality of the fetal cardiovascular system (HP:0010948)3.29342241
27Aortic aneurysm (HP:0004942)3.28043501
28Failure to thrive in infancy (HP:0001531)3.25566338
29Poor suck (HP:0002033)3.25379438
30Absence seizures (HP:0002121)3.21476075
31Abnormal hair whorl (HP:0010721)3.20693100
32Dialeptic seizures (HP:0011146)3.15471748
33Blue irides (HP:0000635)3.11958712
34Abnormality of the labia minora (HP:0012880)3.06953400
35Soft skin (HP:0000977)3.01863774
36Spondylolisthesis (HP:0003302)3.00297540
37Protruding tongue (HP:0010808)2.99984614
38Short nail (HP:0001799)2.99943389
39Neoplasm of head and neck (HP:0012288)2.98819754
40Esophageal neoplasm (HP:0100751)2.98819754
41Wormian bones (HP:0002645)2.98691868
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.95892837
43Osteolytic defects of the hand bones (HP:0009699)2.95892837
44Reduced subcutaneous adipose tissue (HP:0003758)2.95187972
45Abnormality of the umbilical cord (HP:0010881)2.92866342
46Abnormal eating behavior (HP:0100738)2.91316302
47Absent speech (HP:0001344)2.90816304
48Gait imbalance (HP:0002141)2.89861324
49Bladder diverticulum (HP:0000015)2.89480657
503-Methylglutaconic aciduria (HP:0003535)2.85975356
51Generalized tonic-clonic seizures (HP:0002069)2.84698096
52Spinal rigidity (HP:0003306)2.83318555
53Wrist flexion contracture (HP:0001239)2.83234176
54Shallow orbits (HP:0000586)2.81013089
55Cardiovascular calcification (HP:0011915)2.78401818
56Broad metatarsal (HP:0001783)2.77962813
57Fragile skin (HP:0001030)2.77270828
58Excessive salivation (HP:0003781)2.73451024
59Drooling (HP:0002307)2.73451024
60Abnormal social behavior (HP:0012433)2.73167582
61Impaired social interactions (HP:0000735)2.73167582
62Medial flaring of the eyebrow (HP:0010747)2.71497977
63Abnormality of the distal phalanges of the toes (HP:0010182)2.69153109
64Hand muscle atrophy (HP:0009130)2.68129753
65Distal upper limb amyotrophy (HP:0007149)2.67493722
66Upper limb amyotrophy (HP:0009129)2.67493722
67Split foot (HP:0001839)2.64347820
68Congenital primary aphakia (HP:0007707)2.63402978
69Oligomenorrhea (HP:0000876)2.62280168
70Blue sclerae (HP:0000592)2.59529000
71Entropion (HP:0000621)2.57524658
72Inability to walk (HP:0002540)2.56486424
73Neonatal short-limb short stature (HP:0008921)2.54601802
74Sleep apnea (HP:0010535)2.54418769
75Genu recurvatum (HP:0002816)2.54126498
76Narrow nasal bridge (HP:0000446)2.53679459
77Nephrogenic diabetes insipidus (HP:0009806)2.53131996
78Spinal canal stenosis (HP:0003416)2.51900176
79Visual hallucinations (HP:0002367)2.50155929
80Nuclear cataract (HP:0100018)2.45877461
81Abnormality of dentin (HP:0010299)2.43236316
82Poor eye contact (HP:0000817)2.42994581
83Hyperthyroidism (HP:0000836)2.41864501
84Humeroradial synostosis (HP:0003041)2.41816560
85Synostosis involving the elbow (HP:0003938)2.41816560
86Mitral stenosis (HP:0001718)2.41175942
87Epileptiform EEG discharges (HP:0011182)2.40600268
88Short clavicles (HP:0000894)2.40447335
89EEG with generalized epileptiform discharges (HP:0011198)2.39419800
90Specific learning disability (HP:0001328)2.39287799
91Esotropia (HP:0000565)2.37298316
92Hypsarrhythmia (HP:0002521)2.36883228
93Fetal akinesia sequence (HP:0001989)2.36787529
94Abnormal mitochondria in muscle tissue (HP:0008316)2.35546105
95Glucose intolerance (HP:0000833)2.34741447
96Genital tract atresia (HP:0001827)2.33412265
97Renal duplication (HP:0000075)2.32626158
98Delayed gross motor development (HP:0002194)2.31900341
99Vaginal atresia (HP:0000148)2.31442213
100Acute necrotizing encephalopathy (HP:0006965)2.31403721
101Delayed cranial suture closure (HP:0000270)2.27825619
102Hydroureter (HP:0000072)2.26112350
103Hypoventilation (HP:0002791)2.25069579
104Resting tremor (HP:0002322)2.21618560
105Elbow flexion contracture (HP:0002987)2.21003953
106Generalized hypotonia (HP:0001290)2.20860031
107Bowel diverticulosis (HP:0005222)2.20555704
108Absent frontal sinuses (HP:0002688)2.18579993
109Progressive macrocephaly (HP:0004481)2.17883181
110Anxiety (HP:0000739)2.16038014
111Hypothermia (HP:0002045)2.14512746
112Mitral regurgitation (HP:0001653)2.14236321
113Hyperextensible skin (HP:0000974)2.14188834
114Abnormality of the acetabulum (HP:0003170)2.13837626
115Growth hormone deficiency (HP:0000824)2.13608122
116Spinal cord compression (HP:0002176)2.10387487
117Dilatation of the ascending aorta (HP:0005111)2.10043066
118Adrenal hypoplasia (HP:0000835)2.08760015
119Myelomeningocele (HP:0002475)2.08533042
120Abnormality of carpal bone ossification (HP:0006257)2.07759726
121Oligodactyly (hands) (HP:0001180)2.07163059
122Microglossia (HP:0000171)2.05886050
123Vascular calcification (HP:0004934)2.05571361
124Fair hair (HP:0002286)2.02406490
125Abnormal delivery (HP:0001787)2.01805861
126Hypoplastic pelvis (HP:0008839)2.01572727
127Large hands (HP:0001176)2.00204557
128Short middle phalanx of the 5th finger (HP:0004220)1.98724570
129Progressive cerebellar ataxia (HP:0002073)1.98675791
130Aortic regurgitation (HP:0001659)1.96814868
131Follicular hyperkeratosis (HP:0007502)1.96324298
132Ulnar bowing (HP:0003031)1.95675403
133Difficulty climbing stairs (HP:0003551)1.95187831
134Natal tooth (HP:0000695)1.94992905
135Supranuclear gaze palsy (HP:0000605)1.93007861
136Aplasia/Hypoplasia of the clavicles (HP:0006710)1.92968194
137Knee flexion contracture (HP:0006380)1.92236251
138Myocardial infarction (HP:0001658)1.92108393
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91765098
140Aortic valve stenosis (HP:0001650)1.91529562
141Abnormal ossification of hand bones (HP:0005921)1.91120087
142Poor coordination (HP:0002370)1.90806903
143Generalized amyotrophy (HP:0003700)1.89721526
144Mitochondrial inheritance (HP:0001427)1.89319846
145Sporadic (HP:0003745)1.89261208
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88372979
147Syringomyelia (HP:0003396)1.88369197
148Spinal cord lesions (HP:0100561)1.88369197
149Long palpebral fissure (HP:0000637)1.87703130
150Joint stiffness (HP:0001387)1.86085919
151Postural instability (HP:0002172)1.85199591
152Hypoplastic left heart (HP:0004383)1.85057808
153Abnormality of binocular vision (HP:0011514)1.84831700
154Diplopia (HP:0000651)1.84831700
155Scrotal hypoplasia (HP:0000046)1.84416774
156Bell-shaped thorax (HP:0001591)1.83948534
157Mesomelia (HP:0003027)1.83539275
158Decreased subcutaneous fat (HP:0001002)1.82209993
159Labial hypoplasia (HP:0000066)1.81520645
160Abnormalities of placenta or umbilical cord (HP:0001194)1.81493939
161Gastroesophageal reflux (HP:0002020)1.81351602
162Abnormality of salivation (HP:0100755)1.80586000
163Abnormality of the vocal cords (HP:0008777)1.80144087
164Congenital glaucoma (HP:0001087)1.78861935
165Abnormality of the hip-girdle musculature (HP:0001445)1.77189589
166Abnormality of the musculature of the pelvis (HP:0001469)1.77189589
167Impaired pain sensation (HP:0007328)1.75985061
168Abnormality of pain sensation (HP:0010832)1.75985061
169Depression (HP:0000716)1.75188830
170Dysdiadochokinesis (HP:0002075)1.74837600
171Thin skin (HP:0000963)1.74754697
172Agitation (HP:0000713)1.74430343
173Hepatocellular necrosis (HP:0001404)1.74133849
174Open mouth (HP:0000194)1.74000488
175Acute encephalopathy (HP:0006846)1.73488867
176Bradykinesia (HP:0002067)1.72907365
177Mitral valve prolapse (HP:0001634)1.72270097
178Abnormal hand bone ossification (HP:0010660)1.71630781
179Hypoalphalipoproteinemia (HP:0003233)1.71483021
180Hypoplasia of the iris (HP:0007676)1.70792771
181Axonal loss (HP:0003447)1.69699874
182Exercise-induced myalgia (HP:0003738)1.69651249
183Achilles tendon contracture (HP:0001771)1.69391953
184Limb-girdle muscle atrophy (HP:0003797)1.69206711
185Aplasia/Hypoplasia of the lens (HP:0008063)1.68798821
186Delayed closure of the anterior fontanelle (HP:0001476)1.68492462
187Abnormality of the anterior chamber (HP:0000593)1.68303134
188Short foot (HP:0001773)1.68140225
189Broad foot (HP:0001769)1.68040282
190Thickened helices (HP:0000391)1.67612764
191Neurofibrillary tangles (HP:0002185)1.66459200
192Infantile muscular hypotonia (HP:0008947)1.65391199
193Shoulder girdle muscle weakness (HP:0003547)1.65033202
194Distal lower limb muscle weakness (HP:0009053)1.65025335
195Hip dysplasia (HP:0001385)1.64832509
196Upper limb muscle weakness (HP:0003484)1.64601306
197Mild short stature (HP:0003502)1.64360549
198Meningocele (HP:0002435)1.64349303
199Akinesia (HP:0002304)1.63561938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.01135156
2NTRK35.46637151
3LIMK14.60492565
4TESK14.17254165
5MAP3K123.20522690
6VRK22.68804441
7EPHA22.67036641
8NME22.56427284
9ERBB42.54398125
10ADRBK22.40019251
11PAK42.31844686
12AKT32.30340423
13MARK12.23767562
14PTK22.16278769
15MOS2.14533593
16TESK22.13955638
17ARAF2.02866013
18MUSK1.97582675
19NTRK21.97038204
20PRKD31.96213692
21MAP2K71.90302164
22BUB11.88188457
23IRAK31.85998891
24TTN1.81439596
25MAP3K41.76435198
26SIK31.75776968
27GRK71.71338350
28MET1.70280574
29PAK21.69557118
30MINK11.67781905
31EPHB21.62763919
32DDR21.62749789
33MAPK131.55585387
34NEK11.53876992
35PHKG11.43978219
36PHKG21.43978219
37TSSK61.43900850
38PRKCG1.41131696
39TGFBR21.39400562
40LMTK21.38892088
41PRPF4B1.38584372
42MAP3K91.38291861
43TAF11.37809422
44EPHA41.36443809
45PLK21.35729698
46MAP2K41.29075011
47ILK1.27378456
48PIM21.24659620
49PBK1.23291858
50NEK91.21598490
51GRK51.21450691
52STK101.18605335
53SGK21.16372526
54PLK41.10677305
55ROCK11.09511869
56UHMK11.07779812
57PTK2B1.07352163
58PRKCE1.04650918
59ABL21.04443439
60STK381.03247478
61SGK4941.02832566
62SGK2231.02832566
63DAPK31.01712028
64YES10.99847176
65DMPK0.97598651
66CDK50.97567095
67SIK20.97409791
68PAK10.97367959
69MST1R0.96600870
70CAMK2A0.92679891
71BRSK10.91880313
72PDGFRA0.89451271
73SGK30.88910651
74TNK20.88726195
75NME10.87691243
76TRIM280.86567380
77CAMK2B0.86249100
78PDK30.81595838
79PDK40.81595838
80TRPM70.79013050
81MATK0.77912329
82CAMK2G0.77308323
83PLK30.76082247
84STK160.74707294
85AURKA0.73801604
86MELK0.72512334
87DAPK10.72186020
88BCR0.71523626
89CAMK2D0.71492719
90CSNK1G20.69920542
91CSNK1G30.69205622
92WNK30.68431523
93DYRK1A0.67343881
94TAOK20.66606357
95NEK20.66461681
96NEK60.66344623
97BRAF0.65943045
98FES0.65854330
99PRKD20.65739554
100TNIK0.65655972
101MKNK20.65285810
102FLT30.65129815
103ADRBK10.64022715
104PAK60.63952573
105ERBB30.62763638
106CCNB10.61878920
107DAPK20.61666151
108RIPK40.60288800
109STK38L0.59693876
110MAP3K80.58176960
111PLK10.57918741
112CDK180.57853675
113PKN10.57271058
114DYRK20.56881459
115FER0.55637256
116PDK20.54686365
117KSR10.54441026
118ICK0.52655897
119CDK90.51840709
120MAPKAPK50.51484239
121CDK150.51432095
122LRRK20.50858094
123WEE10.50629312
124CDK140.50509320
125PRKACA0.50423619
126PNCK0.50070630
127PRKG20.49660622
128GSK3A0.49093550
129VRK10.48456845
130CDK80.48153623
131SMG10.47779257
132CDK30.47654454
133PINK10.46990083
134NTRK10.46353813
135CAMKK10.45194323
136SIK10.45117161
137CAMK1G0.44426297
138IRAK20.44425764
139RPS6KA30.44015890
140PRKCB0.43900007
141CDK11A0.43749657
142MAP3K30.43721176
143CAMK1D0.43472882
144BMPR20.43332455
145MYLK0.42338616
146NUAK10.42288763
147LATS20.41328376
148STK30.40575000
149CAMK10.39571972
150TIE10.39150416
151SGK10.38123787
152PRKACG0.38013443
153CDK70.37642723
154CHEK20.37233140
155ERN10.36196182
156EPHA30.35828113
157OXSR10.35347030
158EIF2AK10.35055040
159ROCK20.34980680
160INSRR0.34911244
161CSNK1A10.34890455
162PRKCA0.34705179
163FGR0.34598370
164LATS10.33453406
165TGFBR10.32882958
166TTK0.32245065
167PRKD10.32117783
168SCYL20.31986384
169MAP3K60.31710750
170AURKB0.31659642

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.40077589
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48579914
3Collecting duct acid secretion_Homo sapiens_hsa049663.09934053
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.86243540
5GABAergic synapse_Homo sapiens_hsa047272.81634817
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71371220
7ECM-receptor interaction_Homo sapiens_hsa045122.69537912
8Olfactory transduction_Homo sapiens_hsa047402.58436581
9Morphine addiction_Homo sapiens_hsa050322.48940629
10Glutamatergic synapse_Homo sapiens_hsa047242.35743181
11Oxidative phosphorylation_Homo sapiens_hsa001902.16599320
12Focal adhesion_Homo sapiens_hsa045102.15482882
13Circadian entrainment_Homo sapiens_hsa047132.07251001
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.04652787
15Vibrio cholerae infection_Homo sapiens_hsa051102.03386790
16Proteasome_Homo sapiens_hsa030501.98487254
17Amphetamine addiction_Homo sapiens_hsa050311.95982282
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93625674
19Proteoglycans in cancer_Homo sapiens_hsa052051.87984237
20Dopaminergic synapse_Homo sapiens_hsa047281.85189957
21Long-term potentiation_Homo sapiens_hsa047201.84911031
22TGF-beta signaling pathway_Homo sapiens_hsa043501.82803736
23Long-term depression_Homo sapiens_hsa047301.78737844
24Hippo signaling pathway_Homo sapiens_hsa043901.77270430
25Folate biosynthesis_Homo sapiens_hsa007901.71636558
26Protein export_Homo sapiens_hsa030601.70835266
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70452660
28Serotonergic synapse_Homo sapiens_hsa047261.67026131
29Taste transduction_Homo sapiens_hsa047421.63885511
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63141382
31Cocaine addiction_Homo sapiens_hsa050301.58551232
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.58460116
33Insulin secretion_Homo sapiens_hsa049111.55208754
34Basal cell carcinoma_Homo sapiens_hsa052171.54132042
35Parkinsons disease_Homo sapiens_hsa050121.52653611
36Sulfur relay system_Homo sapiens_hsa041221.47701609
37Salivary secretion_Homo sapiens_hsa049701.46976975
38Calcium signaling pathway_Homo sapiens_hsa040201.46101270
39Cardiac muscle contraction_Homo sapiens_hsa042601.46078261
40N-Glycan biosynthesis_Homo sapiens_hsa005101.43108590
41Cholinergic synapse_Homo sapiens_hsa047251.41056272
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39934408
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36983865
44Gastric acid secretion_Homo sapiens_hsa049711.36914087
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36527371
46Nucleotide excision repair_Homo sapiens_hsa034201.36113667
47p53 signaling pathway_Homo sapiens_hsa041151.35930042
48Small cell lung cancer_Homo sapiens_hsa052221.33706456
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29737722
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27650409
51Cell cycle_Homo sapiens_hsa041101.26544940
52Basal transcription factors_Homo sapiens_hsa030221.25371388
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25113494
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.24632930
55Bladder cancer_Homo sapiens_hsa052191.23131666
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22935312
57Shigellosis_Homo sapiens_hsa051311.22543242
58Butanoate metabolism_Homo sapiens_hsa006501.22417204
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21424113
60Amoebiasis_Homo sapiens_hsa051461.20710580
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19448788
62Renin secretion_Homo sapiens_hsa049241.18541619
63Alzheimers disease_Homo sapiens_hsa050101.18367443
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18260705
65Adherens junction_Homo sapiens_hsa045201.15778305
66Gap junction_Homo sapiens_hsa045401.13765539
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13452691
68Type I diabetes mellitus_Homo sapiens_hsa049401.12409707
69Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10750852
70Oxytocin signaling pathway_Homo sapiens_hsa049211.10129024
71Axon guidance_Homo sapiens_hsa043601.07648550
72Glioma_Homo sapiens_hsa052141.07475064
73Sulfur metabolism_Homo sapiens_hsa009201.06411823
74SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05885751
75Rheumatoid arthritis_Homo sapiens_hsa053231.03645096
76Dilated cardiomyopathy_Homo sapiens_hsa054141.00149510
77Galactose metabolism_Homo sapiens_hsa000520.94878301
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94122187
79Glutathione metabolism_Homo sapiens_hsa004800.93715386
80Huntingtons disease_Homo sapiens_hsa050160.93531981
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92228446
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90511628
83Endocytosis_Homo sapiens_hsa041440.90174986
84Biosynthesis of amino acids_Homo sapiens_hsa012300.88399197
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86841233
86GnRH signaling pathway_Homo sapiens_hsa049120.86142695
87Phagosome_Homo sapiens_hsa041450.85406368
88Base excision repair_Homo sapiens_hsa034100.82737083
89cAMP signaling pathway_Homo sapiens_hsa040240.81952349
90Mismatch repair_Homo sapiens_hsa034300.81875859
91Lysosome_Homo sapiens_hsa041420.79801994
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79330221
93ErbB signaling pathway_Homo sapiens_hsa040120.78106246
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78079042
95Pathways in cancer_Homo sapiens_hsa052000.76820246
96Pyrimidine metabolism_Homo sapiens_hsa002400.75798131
97Estrogen signaling pathway_Homo sapiens_hsa049150.74445193
98Melanogenesis_Homo sapiens_hsa049160.73669373
99Protein digestion and absorption_Homo sapiens_hsa049740.73141726
100MicroRNAs in cancer_Homo sapiens_hsa052060.72032335
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71719755
102Melanoma_Homo sapiens_hsa052180.71677009
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71552954
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70732190
105Phototransduction_Homo sapiens_hsa047440.69653877
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68329333
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67236451
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66039392
109Other glycan degradation_Homo sapiens_hsa005110.66001629
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65084251
111Pancreatic cancer_Homo sapiens_hsa052120.64845621
112MAPK signaling pathway_Homo sapiens_hsa040100.64756242
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63246022
114DNA replication_Homo sapiens_hsa030300.62695835
115Fatty acid elongation_Homo sapiens_hsa000620.62073857
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61060644
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.60253389
118Salmonella infection_Homo sapiens_hsa051320.58227383
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57846601
120Pentose phosphate pathway_Homo sapiens_hsa000300.57241062
121Ovarian steroidogenesis_Homo sapiens_hsa049130.55769039
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55060795
123Fatty acid biosynthesis_Homo sapiens_hsa000610.54709630
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53960883
125Tight junction_Homo sapiens_hsa045300.53949026
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52996955
127Alcoholism_Homo sapiens_hsa050340.51913452
128Thyroid hormone synthesis_Homo sapiens_hsa049180.50540687
129Prion diseases_Homo sapiens_hsa050200.49064305
130Chronic myeloid leukemia_Homo sapiens_hsa052200.48603264
131Pyruvate metabolism_Homo sapiens_hsa006200.44202348
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43166155
133Glucagon signaling pathway_Homo sapiens_hsa049220.41391535
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41270706
135Steroid biosynthesis_Homo sapiens_hsa001000.41040549
136Colorectal cancer_Homo sapiens_hsa052100.40327383
137Ras signaling pathway_Homo sapiens_hsa040140.39882683
138Carbon metabolism_Homo sapiens_hsa012000.39113455
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38111876
140Rap1 signaling pathway_Homo sapiens_hsa040150.38104264
141Type II diabetes mellitus_Homo sapiens_hsa049300.37687741
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37484541
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37161955
144Circadian rhythm_Homo sapiens_hsa047100.37135897
145Vitamin B6 metabolism_Homo sapiens_hsa007500.36503878
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.36083753
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36024423
148Mineral absorption_Homo sapiens_hsa049780.35351930
149Sphingolipid metabolism_Homo sapiens_hsa006000.34844820
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.34744808
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.34374819
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34240998
153Phenylalanine metabolism_Homo sapiens_hsa003600.32408440
154beta-Alanine metabolism_Homo sapiens_hsa004100.32246619
155Oocyte meiosis_Homo sapiens_hsa041140.28064944
156Hedgehog signaling pathway_Homo sapiens_hsa043400.27886664
157Wnt signaling pathway_Homo sapiens_hsa043100.27506993
158Pancreatic secretion_Homo sapiens_hsa049720.26009374
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25713959
160Dorso-ventral axis formation_Homo sapiens_hsa043200.21026199
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19782256
162Choline metabolism in cancer_Homo sapiens_hsa052310.18035347
163Ether lipid metabolism_Homo sapiens_hsa005650.17991749
164Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17226939
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.15403996

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