PLPP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)9.26082015
2signal peptide processing (GO:0006465)9.03810093
3protein retention in ER lumen (GO:0006621)8.52850480
4exocrine pancreas development (GO:0031017)7.52125599
5COPII vesicle coating (GO:0048208)6.88470904
6protein maturation by protein folding (GO:0022417)6.81745853
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.91664122
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.59605939
9positive regulation of nuclease activity (GO:0032075)5.42580225
10ER overload response (GO:0006983)5.39620226
11endocrine pancreas development (GO:0031018)5.32243978
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.28681505
13ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.21109189
14GDP-mannose metabolic process (GO:0019673)5.15174609
15protein N-linked glycosylation via asparagine (GO:0018279)5.11987757
16peptidyl-asparagine modification (GO:0018196)5.05452485
17regulation of nuclease activity (GO:0032069)4.99436267
18endoplasmic reticulum unfolded protein response (GO:0030968)4.95213517
19cellular response to unfolded protein (GO:0034620)4.87087979
20glandular epithelial cell differentiation (GO:0002067)4.83127873
21cellular response to topologically incorrect protein (GO:0035967)4.81756850
22sequestering of metal ion (GO:0051238)4.74009216
23peptide hormone processing (GO:0016486)4.65835889
24protein N-linked glycosylation (GO:0006487)4.64632079
25UDP-N-acetylglucosamine metabolic process (GO:0006047)4.62671268
26ER-nucleus signaling pathway (GO:0006984)4.56164725
27axoneme assembly (GO:0035082)4.56108123
28vesicle coating (GO:0006901)4.37880756
29platelet dense granule organization (GO:0060155)4.32984692
30epithelial cilium movement (GO:0003351)4.30873476
31intestinal cholesterol absorption (GO:0030299)4.25555189
32response to endoplasmic reticulum stress (GO:0034976)4.23733647
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.13015839
34cytochrome complex assembly (GO:0017004)4.09614894
35type B pancreatic cell development (GO:0003323)4.06705081
36negative regulation of telomere maintenance (GO:0032205)4.04764256
37protein complex biogenesis (GO:0070271)4.03456539
38ER to Golgi vesicle-mediated transport (GO:0006888)4.00397120
39water-soluble vitamin biosynthetic process (GO:0042364)3.96851268
40regulation of type B pancreatic cell apoptotic process (GO:2000674)3.94902455
41dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.90818883
42nucleotide-sugar biosynthetic process (GO:0009226)3.80177492
43proline biosynthetic process (GO:0006561)3.78090104
44digestion (GO:0007586)3.78075255
45response to unfolded protein (GO:0006986)3.76632876
46cilium movement (GO:0003341)3.76358411
47nucleotide-sugar metabolic process (GO:0009225)3.76168521
48peptidyl-proline hydroxylation (GO:0019511)3.72045800
49cell redox homeostasis (GO:0045454)3.72032605
50response to topologically incorrect protein (GO:0035966)3.71245812
51mitochondrial calcium ion transport (GO:0006851)3.69689107
52L-fucose catabolic process (GO:0042355)3.66222177
53fucose catabolic process (GO:0019317)3.66222177
54L-fucose metabolic process (GO:0042354)3.66222177
55DNA deamination (GO:0045006)3.61636464
56preassembly of GPI anchor in ER membrane (GO:0016254)3.59589343
57mitochondrial respiratory chain complex assembly (GO:0033108)3.57200715
58nucleotide transmembrane transport (GO:1901679)3.47047995
59peptidyl-histidine modification (GO:0018202)3.45282611
60regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.45182365
61protein neddylation (GO:0045116)3.43281996
624-hydroxyproline metabolic process (GO:0019471)3.43201514
63regulation of glucokinase activity (GO:0033131)3.42194294
64regulation of hexokinase activity (GO:1903299)3.42194294
65regulation of cilium movement (GO:0003352)3.36853565
66intestinal epithelial cell development (GO:0060576)3.36327419
67auditory receptor cell differentiation (GO:0042491)3.31840407
68GPI anchor metabolic process (GO:0006505)3.31548912
69glandular epithelial cell development (GO:0002068)3.30112729
70cilium or flagellum-dependent cell motility (GO:0001539)3.26849732
71maintenance of protein localization in organelle (GO:0072595)3.24207781
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21678062
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.21678062
74NADH dehydrogenase complex assembly (GO:0010257)3.21678062
75positive regulation of respiratory burst (GO:0060267)3.20286488
76intestinal absorption (GO:0050892)3.19700100
77GPI anchor biosynthetic process (GO:0006506)3.19520510
78anterograde synaptic vesicle transport (GO:0048490)3.17386469
79intra-Golgi vesicle-mediated transport (GO:0006891)3.14965039
80pteridine-containing compound biosynthetic process (GO:0042559)3.12714708
81axonemal dynein complex assembly (GO:0070286)3.12606561
82nucleoside diphosphate catabolic process (GO:0009134)3.12526374
83columnar/cuboidal epithelial cell development (GO:0002066)3.11688539
84intraciliary transport (GO:0042073)3.10396011
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09672949
86misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.08928584
87regulation of protein glycosylation (GO:0060049)3.06190433
88positive regulation of insulin secretion (GO:0032024)3.06023748
89regulation of telomere maintenance via telomerase (GO:0032210)3.05587969
90zinc ion transport (GO:0006829)3.03336802
91C-terminal protein lipidation (GO:0006501)3.03111417
92response to pheromone (GO:0019236)3.00810557
93chaperone mediated protein folding requiring cofactor (GO:0051085)2.99316783
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99299063
95Golgi organization (GO:0007030)2.97820736
96negative regulation of glycoprotein biosynthetic process (GO:0010561)2.97803079
97cellular ketone body metabolic process (GO:0046950)2.97264257
98protein hydroxylation (GO:0018126)2.96705475
99cytidine deamination (GO:0009972)2.96061918
100cytidine metabolic process (GO:0046087)2.96061918
101cytidine catabolic process (GO:0006216)2.96061918
102protein localization to Golgi apparatus (GO:0034067)2.92927476
103regulation of telomere maintenance (GO:0032204)2.92119937
104mannosylation (GO:0097502)2.91066228
105endosome to pigment granule transport (GO:0043485)2.87949847
106endosome to melanosome transport (GO:0035646)2.87949847
107nonmotile primary cilium assembly (GO:0035058)2.87453957
108glutathione derivative metabolic process (GO:1901685)2.84907153
109glutathione derivative biosynthetic process (GO:1901687)2.84907153
110pyrimidine ribonucleoside catabolic process (GO:0046133)2.83746930
111folic acid-containing compound biosynthetic process (GO:0009396)2.83210477
112fucose metabolic process (GO:0006004)2.82643387
113response to misfolded protein (GO:0051788)2.82359253
114chaperone-mediated protein folding (GO:0061077)2.81294197
115peptide catabolic process (GO:0043171)2.80518430
116insulin secretion (GO:0030073)2.80386147
117peptidyl-proline modification (GO:0018208)2.80266892
118protein localization to cilium (GO:0061512)2.79466560
119C-terminal protein amino acid modification (GO:0018410)2.79172691
120regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.78246503
121protein autoprocessing (GO:0016540)2.77541506
122rRNA methylation (GO:0031167)2.75697696
123positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.73550468
124S-adenosylmethionine metabolic process (GO:0046500)2.73280015
125cellular zinc ion homeostasis (GO:0006882)2.73218016
126eosinophil chemotaxis (GO:0048245)2.72191496
127protein-cofactor linkage (GO:0018065)2.71906683
128adaptation of signaling pathway (GO:0023058)2.71675263
129behavioral response to nicotine (GO:0035095)2.69551906
130cilium morphogenesis (GO:0060271)2.68790179
131cellular response to vitamin D (GO:0071305)2.68343807
132regulation of insulin secretion (GO:0050796)2.67208132
133cilium organization (GO:0044782)2.65906565
134SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65540381
135post-translational protein modification (GO:0043687)2.65058002
136response to nitrosative stress (GO:0051409)2.65030630
137purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.64322065
1383-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.64322065
139purine nucleotide salvage (GO:0032261)2.62913911
140respiratory chain complex IV assembly (GO:0008535)2.62088966
141response to redox state (GO:0051775)2.61701129
142protein peptidyl-prolyl isomerization (GO:0000413)2.61622601
143xenobiotic catabolic process (GO:0042178)2.60957748
144transcytosis (GO:0045056)2.60792652
145photoreceptor cell maintenance (GO:0045494)2.60431339
146glycolipid biosynthetic process (GO:0009247)2.59336824
147epithelial cell maturation (GO:0002070)2.58663179
148protein targeting to ER (GO:0045047)2.56639520
149ketone body metabolic process (GO:1902224)2.56548874
150neural tube formation (GO:0001841)2.55857448
151cilium assembly (GO:0042384)2.55547870
152cotranslational protein targeting to membrane (GO:0006613)2.55269504
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54019665
154electron transport chain (GO:0022900)2.53658491
155Golgi vesicle transport (GO:0048193)2.53623316
156nucleobase catabolic process (GO:0046113)2.52043569
157rRNA modification (GO:0000154)2.51004485
158amine catabolic process (GO:0009310)2.50967683
159cellular biogenic amine catabolic process (GO:0042402)2.50967683
160glycerophospholipid catabolic process (GO:0046475)2.49252013
161neutrophil mediated immunity (GO:0002446)2.48412532
162negative regulation of transcription by competitive promoter binding (GO:0010944)2.46533153
163regulation of autophagic vacuole assembly (GO:2000785)2.44872030
164positive regulation of protein homodimerization activity (GO:0090073)2.44643675
165brain morphogenesis (GO:0048854)2.44382034
166eosinophil migration (GO:0072677)2.44347886
167positive regulation of glycolytic process (GO:0045821)2.43458711
168respiratory electron transport chain (GO:0022904)2.43086544
169estrogen biosynthetic process (GO:0006703)2.42696433
170indolalkylamine metabolic process (GO:0006586)2.40596715
171detection of light stimulus involved in sensory perception (GO:0050962)2.40393699
172detection of light stimulus involved in visual perception (GO:0050908)2.40393699
173pyrimidine nucleobase catabolic process (GO:0006208)2.36641393
174kidney morphogenesis (GO:0060993)2.35023432
175exogenous drug catabolic process (GO:0042738)2.34403373
176cornea development in camera-type eye (GO:0061303)2.33896773
177inositol phosphate catabolic process (GO:0071545)2.32676986
178proton transport (GO:0015992)2.31879972
179regulation of vacuole organization (GO:0044088)2.30211176
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29780159
181drug catabolic process (GO:0042737)2.28986000
182establishment of protein localization to Golgi (GO:0072600)2.28790120
183negative regulation of neurological system process (GO:0031645)2.28357625
184Golgi transport vesicle coating (GO:0048200)10.5628951
185COPI coating of Golgi vesicle (GO:0048205)10.5628951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.95332112
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.76698989
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.29405401
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.89954209
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.78361160
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.68406826
7ZNF274_21170338_ChIP-Seq_K562_Hela3.54795037
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12668698
9GATA1_22025678_ChIP-Seq_K562_Human2.96510472
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.83640298
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.81272207
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.80648898
13FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.56878545
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56235179
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48504297
16VDR_22108803_ChIP-Seq_LS180_Human2.45239145
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45182407
18GBX2_23144817_ChIP-Seq_PC3_Human2.44179799
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.44080953
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42080985
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40194212
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39354620
23GABP_19822575_ChIP-Seq_HepG2_Human2.37909104
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29157528
25VDR_23849224_ChIP-Seq_CD4+_Human2.28031186
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23362920
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.23240797
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.15114659
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14814641
30DCP1A_22483619_ChIP-Seq_HELA_Human2.08255541
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08131341
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07913790
33PIAS1_25552417_ChIP-Seq_VCAP_Human2.06302447
34MYC_18555785_ChIP-Seq_MESCs_Mouse2.04118896
35FOXP3_21729870_ChIP-Seq_TREG_Human2.03980769
36TAF15_26573619_Chip-Seq_HEK293_Human2.03962765
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.02996536
38EWS_26573619_Chip-Seq_HEK293_Human2.00692968
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95911014
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94611730
41FUS_26573619_Chip-Seq_HEK293_Human1.90780027
42P300_19829295_ChIP-Seq_ESCs_Human1.89857613
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89182152
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88693595
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86467470
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83336851
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77440613
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76213007
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73253770
50ER_23166858_ChIP-Seq_MCF-7_Human1.73062015
51ELK1_19687146_ChIP-ChIP_HELA_Human1.70726063
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70365865
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69779972
54BCAT_22108803_ChIP-Seq_LS180_Human1.67811949
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.67329978
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61667741
57TFEB_21752829_ChIP-Seq_HELA_Human1.61009686
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60820296
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60518461
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59831874
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57393283
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53522289
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52260657
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52040518
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50800083
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48898433
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48894361
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.48894361
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48612033
70CBP_20019798_ChIP-Seq_JUKART_Human1.48612033
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44665875
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44370276
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.42662959
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.41032692
75AR_25329375_ChIP-Seq_VCAP_Human1.39848136
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.39288067
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38793625
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38003433
79SOX2_19829295_ChIP-Seq_ESCs_Human1.37967905
80NANOG_19829295_ChIP-Seq_ESCs_Human1.37967905
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35309702
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34688081
83HTT_18923047_ChIP-ChIP_STHdh_Human1.33493830
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33112979
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32703639
86TCF4_22108803_ChIP-Seq_LS180_Human1.31245033
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30960458
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30908010
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30517988
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30083448
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30018118
92SMAD4_21799915_ChIP-Seq_A2780_Human1.29150922
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29120141
94ERG_20517297_ChIP-Seq_VCAP_Human1.29009304
95TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28897695
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28799887
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25298711
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.24740941
99CIITA_25753668_ChIP-Seq_RAJI_Human1.24461726
100CDX2_22108803_ChIP-Seq_LS180_Human1.23972241
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23654965
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.23630609
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22406161
104MYC_18940864_ChIP-ChIP_HL60_Human1.22233550
105NCOR_22424771_ChIP-Seq_293T_Human1.21860125
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21772687
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21743970
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21237055
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20293870
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19248311
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19104803
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18826689
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18565570
114RUNX2_22187159_ChIP-Seq_PCA_Human1.17995186
115IRF1_19129219_ChIP-ChIP_H3396_Human1.17208229
116STAT3_23295773_ChIP-Seq_U87_Human1.16726882
117TCF4_23295773_ChIP-Seq_U87_Human1.15995080
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15905561
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.15565262
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14495495
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12758535
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08507675
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08450689
124GATA3_26560356_Chip-Seq_TH2_Human1.08275250
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.08185282
126HOXB7_26014856_ChIP-Seq_BT474_Human1.07249013
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06620379
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.06474085
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06413430
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06330404
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05886754
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05861044
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05553392
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05334239
135KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04711343
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04639439
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.04508043
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04353481
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04257936
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03873484
141KDM5A_27292631_Chip-Seq_BREAST_Human1.02922456
142PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02730436
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02377367
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01138874
145MYC_19829295_ChIP-Seq_ESCs_Human1.00216614
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99236835
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98745914
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98519376
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.98262955
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98108363
151AR_20517297_ChIP-Seq_VCAP_Human0.98046729
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97754455
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96861786
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.96289697
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96122608
156XRN2_22483619_ChIP-Seq_HELA_Human0.95745550
157SPI1_23547873_ChIP-Seq_NB4_Human0.95089036
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94414251
159FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94405258
160TTF2_22483619_ChIP-Seq_HELA_Human0.94318173
161MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94259662
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.94163906
163TAL1_26923725_Chip-Seq_HPCs_Mouse0.93646244
164GATA4_25053715_ChIP-Seq_YYC3_Human0.92593016
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91889634
166MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90284503
167TP63_19390658_ChIP-ChIP_HaCaT_Human0.89649532
168ESR1_21235772_ChIP-Seq_MCF-7_Human0.87288846
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86638409
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85170642
171TP53_22573176_ChIP-Seq_HFKS_Human0.85084137
172MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84373363
173IGF1R_20145208_ChIP-Seq_DFB_Human0.83606730
174RXR_22158963_ChIP-Seq_LIVER_Mouse0.83548641
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83034192
176TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80633649
177NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80426895
178PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80332504
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79627233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005220_abnormal_exocrine_pancreas5.11915900
2MP0002693_abnormal_pancreas_physiology3.95070553
3MP0010386_abnormal_urinary_bladder3.85692872
4MP0001944_abnormal_pancreas_morphology3.77574347
5MP0002877_abnormal_melanocyte_morpholog3.68346584
6MP0003693_abnormal_embryo_hatching3.18981328
7MP0004264_abnormal_extraembryonic_tissu3.04458684
8MP0003787_abnormal_imprinting2.99401140
9MP0001666_abnormal_nutrient_absorption2.97779132
10MP0005365_abnormal_bile_salt2.96674352
11MP0003195_calcinosis2.80770398
12MP0005084_abnormal_gallbladder_morpholo2.76971333
13MP0006054_spinal_hemorrhage2.74113485
14MP0005379_endocrine/exocrine_gland_phen2.74036282
15MP0000013_abnormal_adipose_tissue2.73267472
16MP0003183_abnormal_peptide_metabolism2.70016478
17MP0000678_abnormal_parathyroid_gland2.69313008
18MP0003011_delayed_dark_adaptation2.54459265
19MP0004043_abnormal_pH_regulation2.51366244
20MP0003868_abnormal_feces_composition2.36565248
21MP0005083_abnormal_biliary_tract2.28992144
22MP0002102_abnormal_ear_morphology2.26040907
23MP0000372_irregular_coat_pigmentation2.11110646
24MP0009780_abnormal_chondrocyte_physiolo2.04454673
25MP0008877_abnormal_DNA_methylation2.00956423
26MP0002909_abnormal_adrenal_gland1.92341403
27MP0005551_abnormal_eye_electrophysiolog1.89756227
28MP0002653_abnormal_ependyma_morphology1.88322608
29MP0000613_abnormal_salivary_gland1.86076417
30MP0004133_heterotaxia1.85394922
31MP0002078_abnormal_glucose_homeostasis1.81766329
32MP0008875_abnormal_xenobiotic_pharmacok1.81238151
33MP0002254_reproductive_system_inflammat1.81022978
34MP0002736_abnormal_nociception_after1.80942253
35MP0004147_increased_porphyrin_level1.79318505
36MP0001968_abnormal_touch/_nociception1.78254255
37MP0008872_abnormal_physiological_respon1.76906448
38MP0005646_abnormal_pituitary_gland1.72435777
39MP0002277_abnormal_respiratory_mucosa1.71857748
40MP0002638_abnormal_pupillary_reflex1.69355225
41MP0001188_hyperpigmentation1.56257460
42MP0000427_abnormal_hair_cycle1.55902511
43MP0005253_abnormal_eye_physiology1.53208513
44MP0001986_abnormal_taste_sensitivity1.53118108
45MP0002928_abnormal_bile_duct1.51680217
46MP0003283_abnormal_digestive_organ1.51121268
47MP0006276_abnormal_autonomic_nervous1.48140460
48MP0004019_abnormal_vitamin_homeostasis1.48080645
49MP0001485_abnormal_pinna_reflex1.46828353
50MP0000516_abnormal_urinary_system1.43930133
51MP0005367_renal/urinary_system_phenotyp1.43930133
52MP0000003_abnormal_adipose_tissue1.42384465
53MP0002896_abnormal_bone_mineralization1.39133160
54MP0005408_hypopigmentation1.37480609
55MP0001501_abnormal_sleep_pattern1.32082418
56MP0005332_abnormal_amino_acid1.31737615
57MP0003880_abnormal_central_pattern1.30795977
58MP0005075_abnormal_melanosome_morpholog1.30444370
59MP0000681_abnormal_thyroid_gland1.29266477
60MP0001984_abnormal_olfaction1.28623270
61MP0005257_abnormal_intraocular_pressure1.27958532
62MP0009643_abnormal_urine_homeostasis1.27038248
63MP0003953_abnormal_hormone_level1.25387966
64MP0003136_yellow_coat_color1.24471626
65MP0000490_abnormal_crypts_of1.23705536
66MP0008995_early_reproductive_senescence1.20417159
67MP0002163_abnormal_gland_morphology1.19994846
68MP0006292_abnormal_olfactory_placode1.17710559
69MP0002557_abnormal_social/conspecific_i1.17457707
70MP0002876_abnormal_thyroid_physiology1.16563620
71MP0010329_abnormal_lipoprotein_level1.16217634
72MP0003121_genomic_imprinting1.16000478
73MP0000566_synostosis1.15284424
74MP0002139_abnormal_hepatobiliary_system1.14706202
75MP0005636_abnormal_mineral_homeostasis1.14078566
76MP0002837_dystrophic_cardiac_calcinosis1.14012467
77MP0000383_abnormal_hair_follicle1.12158638
78MP0005058_abnormal_lysosome_morphology1.12014244
79MP0003795_abnormal_bone_structure1.08583460
80MP0001664_abnormal_digestion1.08461072
81MP0008007_abnormal_cellular_replicative1.08175637
82MP0001765_abnormal_ion_homeostasis1.08085114
83MP0006072_abnormal_retinal_apoptosis1.08081889
84MP0008775_abnormal_heart_ventricle1.08059291
85MP0000462_abnormal_digestive_system1.06973234
86MP0002822_catalepsy1.04668665
87MP0005503_abnormal_tendon_morphology1.04564119
88MP0001764_abnormal_homeostasis1.04446750
89MP0009745_abnormal_behavioral_response1.04067073
90MP0001270_distended_abdomen1.03448329
91MP0003122_maternal_imprinting1.03295775
92MP0008789_abnormal_olfactory_epithelium1.00835396
93MP0003879_abnormal_hair_cell0.99491951
94MP0001919_abnormal_reproductive_system0.99120318
95MP0002090_abnormal_vision0.98797807
96MP0002751_abnormal_autonomic_nervous0.95871406
97MP0009384_cardiac_valve_regurgitation0.95254621
98MP0003123_paternal_imprinting0.94803473
99MP0000538_abnormal_urinary_bladder0.93048694
100MP0003943_abnormal_hepatobiliary_system0.92490406
101MP0003172_abnormal_lysosome_physiology0.90427675
102MP0001873_stomach_inflammation0.90404798
103MP0003959_abnormal_lean_body0.89444673
104MP0004885_abnormal_endolymph0.89126997
105MP0002735_abnormal_chemical_nociception0.88920476
106MP0000639_abnormal_adrenal_gland0.88639511
107MP0001970_abnormal_pain_threshold0.88218075
108MP0009046_muscle_twitch0.88193717
109MP0008260_abnormal_autophagy0.88062184
110MP0005310_abnormal_salivary_gland0.87871544
111MP0001905_abnormal_dopamine_level0.86242077
112MP0004782_abnormal_surfactant_physiolog0.85974566
113MP0005085_abnormal_gallbladder_physiolo0.85027300
114MP0002733_abnormal_thermal_nociception0.83126643
115MP0005389_reproductive_system_phenotype0.83077062
116MP0001533_abnormal_skeleton_physiology0.82829129
117MP0003724_increased_susceptibility_to0.82746361
118MP0000163_abnormal_cartilage_morphology0.81674821
119MP0000230_abnormal_systemic_arterial0.81475752
120MP0001756_abnormal_urination0.81169337
121MP0003786_premature_aging0.80865269
122MP0002272_abnormal_nervous_system0.80492802
123MP0004270_analgesia0.80486294
124MP0004142_abnormal_muscle_tone0.78969085
125MP0002938_white_spotting0.78856794
126MP0008058_abnormal_DNA_repair0.78558679
127MP0005671_abnormal_response_to0.78401226
128MP0010234_abnormal_vibrissa_follicle0.78271488
129MP0003718_maternal_effect0.78155935
130MP0000015_abnormal_ear_pigmentation0.77270044
131MP0005390_skeleton_phenotype0.76905729
132MP0006035_abnormal_mitochondrial_morpho0.76831672
133MP0004742_abnormal_vestibular_system0.75768567
134MP0002177_abnormal_outer_ear0.75691202
135MP0003252_abnormal_bile_duct0.75687656
136MP0004957_abnormal_blastocyst_morpholog0.75432669
137MP0005448_abnormal_energy_balance0.75114563
138MP0002572_abnormal_emotion/affect_behav0.73838883
139MP0005645_abnormal_hypothalamus_physiol0.71781753
140MP0008438_abnormal_cutaneous_collagen0.70359375
141MP0000631_abnormal_neuroendocrine_gland0.69947334
142MP0002933_joint_inflammation0.69587369
143MP0002138_abnormal_hepatobiliary_system0.68377152
144MP0008004_abnormal_stomach_pH0.66529195
145MP0003890_abnormal_embryonic-extraembry0.65369405
146MP0006036_abnormal_mitochondrial_physio0.65265376
147MP0002396_abnormal_hematopoietic_system0.65209578
148MP0001186_pigmentation_phenotype0.64730308
149MP0009697_abnormal_copulation0.64660865
150MP0005508_abnormal_skeleton_morphology0.63717683
151MP0000470_abnormal_stomach_morphology0.63086153
152MP0005451_abnormal_body_composition0.62488467
153MP0009642_abnormal_blood_homeostasis0.60609119
154MP0002060_abnormal_skin_morphology0.60400510

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.77935651
2Symptomatic seizures (HP:0011145)4.60444564
3Type I transferrin isoform profile (HP:0003642)4.50932431
4Hyperinsulinemic hypoglycemia (HP:0000825)4.39873467
5Hypoglycemic coma (HP:0001325)4.31656411
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.23028811
7Abnormal protein N-linked glycosylation (HP:0012347)4.23028811
8Abnormal protein glycosylation (HP:0012346)4.23028811
9Abnormal glycosylation (HP:0012345)4.23028811
10Abnormality of the intrinsic pathway (HP:0010989)4.15265329
11Insulin-resistant diabetes mellitus (HP:0000831)4.14114062
12Hyperglycemia (HP:0003074)4.08964998
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.90423267
14Generalized aminoaciduria (HP:0002909)3.82153201
15Pancreatic cysts (HP:0001737)3.74142957
16Reduced antithrombin III activity (HP:0001976)3.71766956
17Vacuolated lymphocytes (HP:0001922)3.55240163
18Abnormal pancreas size (HP:0012094)3.39700348
19Aplastic anemia (HP:0001915)3.38420505
20Abnormality of endocrine pancreas physiology (HP:0012093)3.38273230
21Abnormality of the pancreatic islet cells (HP:0006476)3.38273230
22True hermaphroditism (HP:0010459)3.33710632
23Abnormality of midbrain morphology (HP:0002418)3.31747545
24Molar tooth sign on MRI (HP:0002419)3.31747545
25Medial flaring of the eyebrow (HP:0010747)3.21536415
26Nephronophthisis (HP:0000090)3.06912970
27Late onset (HP:0003584)3.04418272
28Mucopolysacchariduria (HP:0008155)2.99569037
29Urinary glycosaminoglycan excretion (HP:0003541)2.99569037
30Abnormality of the renal cortex (HP:0011035)2.97634925
31Acute necrotizing encephalopathy (HP:0006965)2.95515244
32Abnormality of polysaccharide metabolism (HP:0011012)2.95200642
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95200642
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95200642
35Abnormality of calcium-phosphate metabolism (HP:0100530)2.94441797
36Beaking of vertebral bodies (HP:0004568)2.87532733
37Flat capital femoral epiphysis (HP:0003370)2.87518993
38Methylmalonic acidemia (HP:0002912)2.86391653
39Dysostosis multiplex (HP:0000943)2.83363068
40Thoracolumbar scoliosis (HP:0002944)2.81366046
41Abnormality of the renal medulla (HP:0100957)2.80112992
42Mitochondrial inheritance (HP:0001427)2.78639903
43Hypoplasia of the pons (HP:0012110)2.77285076
44Abnormal respiratory motile cilium morphology (HP:0005938)2.74083531
45Abnormal respiratory epithelium morphology (HP:0012253)2.74083531
46Hyperventilation (HP:0002883)2.73749442
47Chronic hepatic failure (HP:0100626)2.71283850
48Abnormality of vitamin B metabolism (HP:0004340)2.70950443
49Ketoacidosis (HP:0001993)2.70687840
50Progressive macrocephaly (HP:0004481)2.69955468
51Disproportionate short-trunk short stature (HP:0003521)2.66530222
52Acute encephalopathy (HP:0006846)2.66051200
53Absent/shortened dynein arms (HP:0200106)2.65639136
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.65639136
55Decreased circulating renin level (HP:0003351)2.61731785
56Abnormality of the pons (HP:0007361)2.61205397
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61150188
58Osteomalacia (HP:0002749)2.59217477
59Insulin resistance (HP:0000855)2.57055110
60Methylmalonic aciduria (HP:0012120)2.56659693
61Hepatocellular necrosis (HP:0001404)2.56360926
62Irregular vertebral endplates (HP:0003301)2.55408542
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54121286
64Congenital stationary night blindness (HP:0007642)2.52697217
65Increased CSF lactate (HP:0002490)2.52378211
66Congenital primary aphakia (HP:0007707)2.51857377
67Hyperglycinemia (HP:0002154)2.49729250
68Abnormal mitochondria in muscle tissue (HP:0008316)2.49441376
69Conjugated hyperbilirubinemia (HP:0002908)2.48154207
70Large for gestational age (HP:0001520)2.47313838
71Gait imbalance (HP:0002141)2.45135836
72Attenuation of retinal blood vessels (HP:0007843)2.41328793
73Renal cortical cysts (HP:0000803)2.37375680
74Nephrogenic diabetes insipidus (HP:0009806)2.37046810
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.35452847
76Hypoplasia of the fovea (HP:0007750)2.35452847
77Cervical subluxation (HP:0003308)2.34700775
78Pancreatic islet-cell hyperplasia (HP:0004510)2.34190147
79Abnormality of the common coagulation pathway (HP:0010990)2.33773329
80Abnormal ciliary motility (HP:0012262)2.33420054
81Abolished electroretinogram (ERG) (HP:0000550)2.31732797
82Abnormal respiratory motile cilium physiology (HP:0012261)2.30938442
83Hypothermia (HP:0002045)2.26007740
84Abnormality of the vitamin B12 metabolism (HP:0004341)2.23477097
85Intestinal atresia (HP:0011100)2.23106918
86Cystic liver disease (HP:0006706)2.22238892
87Tubular atrophy (HP:0000092)2.21727413
88Protuberant abdomen (HP:0001538)2.18652125
89Abnormality of the labia minora (HP:0012880)2.18035002
90Abnormality of the vertebral endplates (HP:0005106)2.15934260
91Bronchiectasis (HP:0002110)2.15757577
92Abnormal albumin level (HP:0012116)2.15612972
93Hypoalbuminemia (HP:0003073)2.15612972
94Limb hypertonia (HP:0002509)2.15268591
95Rhinitis (HP:0012384)2.13835772
96Thrombocytosis (HP:0001894)2.12578077
97Abnormal drinking behavior (HP:0030082)2.12386595
98Polydipsia (HP:0001959)2.12386595
99Abnormality of glycine metabolism (HP:0010895)2.11772085
100Abnormality of serine family amino acid metabolism (HP:0010894)2.11772085
101Polyphagia (HP:0002591)2.11083659
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10873456
103Hyperglycinuria (HP:0003108)2.10620211
104Tubulointerstitial nephritis (HP:0001970)2.10154932
105Progressive neurologic deterioration (HP:0002344)2.09996319
106Chronic bronchitis (HP:0004469)2.09687058
107Abnormality of the fovea (HP:0000493)2.08986824
108Birth length less than 3rd percentile (HP:0003561)2.08748148
109Degeneration of anterior horn cells (HP:0002398)2.07258064
110Abnormality of the anterior horn cell (HP:0006802)2.07258064
111Abnormal hair whorl (HP:0010721)2.06636342
112Joint stiffness (HP:0001387)2.06403870
113Nonimmune hydrops fetalis (HP:0001790)2.04368127
114Male pseudohermaphroditism (HP:0000037)2.04055200
115Gout (HP:0001997)2.03196799
116Occipital encephalocele (HP:0002085)2.02850803
117Flared iliac wings (HP:0002869)1.99757344
118Exocrine pancreatic insufficiency (HP:0001738)1.99332873
119Metaphyseal irregularity (HP:0003025)1.99229944
120Abdominal distention (HP:0003270)1.99085276
121Chronic sinusitis (HP:0011109)1.98881194
122Genital tract atresia (HP:0001827)1.98794053
123Cortical visual impairment (HP:0100704)1.98290115
124Hypoproteinemia (HP:0003075)1.97648745
125Hypoplasia of the odontoid process (HP:0003311)1.96285819
126Thoracic kyphosis (HP:0002942)1.95586091
127Abnormality of subcutaneous fat tissue (HP:0001001)1.95353803
128Lethargy (HP:0001254)1.94360030
129Cerebral edema (HP:0002181)1.93846899
130Vaginal atresia (HP:0000148)1.93817198
131Optic disc pallor (HP:0000543)1.93391491
132Prominent metopic ridge (HP:0005487)1.92831546
133Epiphyseal dysplasia (HP:0002656)1.92804476
134Entropion (HP:0000621)1.92188781
135Pancreatitis (HP:0001733)1.90928485
136Spondylolisthesis (HP:0003302)1.90920631
1373-Methylglutaconic aciduria (HP:0003535)1.90366745
138Abnormality of vitamin metabolism (HP:0100508)1.89250465
139Hyperparathyroidism (HP:0000843)1.88558683
140Coxa valga (HP:0002673)1.88093623
141Hepatic necrosis (HP:0002605)1.86172219
142Severe short stature (HP:0003510)1.84803633
143Hypokalemia (HP:0002900)1.83565870
144Absent speech (HP:0001344)1.83152903
14511 pairs of ribs (HP:0000878)1.82333222
146Aplasia/hypoplasia of the uterus (HP:0008684)1.82315199
147Abnormality of T cell physiology (HP:0011840)1.81875248
148Abnormal tarsal ossification (HP:0008369)1.81803701
149Hypomagnesemia (HP:0002917)1.80338220
150Broad face (HP:0000283)1.79769586
151Abnormal foot bone ossification (HP:0010675)1.79221154
152Congenital glaucoma (HP:0001087)1.78082675
153Congenital sensorineural hearing impairment (HP:0008527)1.77513358
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77406243
155Abnormality of urine glucose concentration (HP:0011016)1.76422744
156Glycosuria (HP:0003076)1.76422744
157Renal Fanconi syndrome (HP:0001994)1.76321321
158Abnormality of the thoracic spine (HP:0100711)1.75854614
159Polyuria (HP:0000103)1.75283345
160Hypsarrhythmia (HP:0002521)1.74884047
161Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74827069
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74827069
163Bony spicule pigmentary retinopathy (HP:0007737)1.74659828
164Long foot (HP:0001833)1.73734769
165Azoospermia (HP:0000027)1.73400462
166Abnormal rod and cone electroretinograms (HP:0008323)1.73209401
167Broad-based gait (HP:0002136)1.72870791
168Lipid accumulation in hepatocytes (HP:0006561)1.72306040
169Congenital hepatic fibrosis (HP:0002612)1.72007869
170Recurrent sinusitis (HP:0011108)1.71794854
171Poor head control (HP:0002421)1.71475329
172Hyperphosphatemia (HP:0002905)1.70981568
173Decreased subcutaneous fat (HP:0001002)1.70679762
174Slender long bone (HP:0003100)1.68941858
175Type II lissencephaly (HP:0007260)1.68437990
176Cerebellar dysplasia (HP:0007033)1.67783383
177Ketosis (HP:0001946)1.67058269
178Irregular epiphyses (HP:0010582)1.66948015
179Pancreatic fibrosis (HP:0100732)1.66511984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.22330209
2MAP4K24.60384114
3ERN14.50943616
4INSRR4.47717481
5EIF2AK33.64289983
6PASK3.35918038
7BCKDK2.87591815
8IRAK32.84866130
9MST42.73571409
10GRK12.67099520
11MAPK152.62787237
12FRK2.53812665
13AKT32.52306600
14FLT32.42478973
15STK162.36710825
16CAMKK22.34108346
17NME22.31054033
18PIK3CG2.30464304
19ADRBK22.16853580
20TLK12.15226061
21PAK32.14790037
22MAP2K62.11700999
23TXK2.10397083
24TRIM282.08448474
25BRAF1.98927093
26STK391.94831147
27HIPK21.88184863
28TAOK21.71903851
29OXSR11.62915251
30WNK41.57276673
31MAP4K11.55599430
32LATS11.54291770
33IRAK41.48333159
34MAPK131.46558974
35EPHA31.46108511
36CASK1.44372498
37CDK81.42300871
38TNK21.38516567
39BRSK21.38020898
40ARAF1.34807532
41TEC1.33977427
42BCR1.32094788
43PINK11.28266895
44STK38L1.21592368
45BMPR1B1.21085491
46ERBB31.18918280
47ACVR1B1.15939837
48PRKCE1.15336078
49MAP3K11.14768102
50MAPKAPK31.12619404
51EIF2AK11.08413716
52VRK11.06493912
53NUAK11.06426911
54DAPK21.05755052
55MAP3K131.05043850
56PRKD31.00339497
57MAP3K41.00201406
58NLK0.99153985
59CSNK1G10.97003460
60PLK40.95089136
61MKNK20.92457457
62SCYL20.92225629
63MAP3K20.92090480
64SIK30.89573468
65IRAK10.89500283
66FGFR20.88492761
67NME10.86719154
68PRKCQ0.85148973
69PIM20.81681397
70BMPR20.81213039
71CSNK1G30.79618630
72MAP2K70.79564359
73CSNK1G20.79312711
74PRKCG0.78823656
75MAP2K20.78770092
76TNIK0.74873112
77RPS6KA40.73845118
78MAP3K30.72354557
79IKBKB0.71453664
80RAF10.70596321
81VRK20.69980237
82MAP3K60.68480144
83JAK30.66271665
84NEK90.65684106
85MUSK0.65632926
86PRKCI0.65258042
87MOS0.64945316
88CDC42BPA0.64385012
89CCNB10.63980101
90ZAP700.63070626
91PLK20.62887548
92DYRK30.60546444
93WNK30.59716811
94MYLK0.58745928
95ZAK0.58271185
96IKBKE0.52736173
97PHKG10.52356480
98PHKG20.52356480
99ADRBK10.51112449
100CSNK1A1L0.50440964
101BRD40.49647673
102EIF2AK20.47998578
103SIK10.47163470
104BRSK10.45805759
105KSR20.45523786
106GRK60.44043309
107RPS6KA20.43032091
108KDR0.42973403
109PRKCZ0.42403878
110RPS6KB10.42014393
111PTK20.41358499
112MARK10.40240527
113MAP3K140.39677047
114KIT0.39311196
115SGK20.38628726
116CDK90.38195635
117PRKACA0.38144661
118BTK0.37880353
119CHUK0.37833405
120PRKAA10.37638936
121PLK30.37429328
122PNCK0.36043821
123KSR10.35850216
124FGFR10.35826072
125ABL10.35663812
126ERBB20.35492597
127PRKCA0.35098850
128PRKAA20.35062311
129MAPKAPK50.34988347
130TRPM70.34627561
131PRKD10.34285605
132CAMK1D0.33424178
133PRKD20.32284549
134MAP2K10.31811253
135AURKB0.31760290
136CAMK2A0.31630477
137RPS6KA50.31611045
138MAPK110.31462384
139PLK10.30008164
140IGF1R0.29731669
141DYRK20.29035916
142PTK2B0.28648398
143ATR0.28565781
144SIK20.28463672
145PRKG20.27903426
146MAPK30.27725043
147STK30.25653694
148MAP3K120.25257909
149NTRK10.24816777
150DYRK1A0.24456087
151CSNK1A10.24234792
152TIE10.24012705
153CDK30.22790093
154MAP3K50.22507155
155FER0.19961162
156JAK20.18294138
157CHEK20.18061431
158CSNK2A10.17165968
159PIK3CA0.17142966

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030608.17902037
2Maturity onset diabetes of the young_Homo sapiens_hsa049507.20272615
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.05622457
4N-Glycan biosynthesis_Homo sapiens_hsa005103.02215773
5Oxidative phosphorylation_Homo sapiens_hsa001902.71525216
6Folate biosynthesis_Homo sapiens_hsa007902.62213684
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.30666065
8Other glycan degradation_Homo sapiens_hsa005112.26376729
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18373536
10Sulfur metabolism_Homo sapiens_hsa009202.11745317
11Butanoate metabolism_Homo sapiens_hsa006502.02423164
12Parkinsons disease_Homo sapiens_hsa050121.92439777
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84918353
14Fatty acid elongation_Homo sapiens_hsa000621.76623620
15Pancreatic secretion_Homo sapiens_hsa049721.76456070
16Phototransduction_Homo sapiens_hsa047441.76220937
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74449653
18Asthma_Homo sapiens_hsa053101.74101872
19Chemical carcinogenesis_Homo sapiens_hsa052041.72040385
20Vibrio cholerae infection_Homo sapiens_hsa051101.71078978
21Selenocompound metabolism_Homo sapiens_hsa004501.66849995
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63752260
23Regulation of autophagy_Homo sapiens_hsa041401.59489023
24Propanoate metabolism_Homo sapiens_hsa006401.57470118
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.56559873
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.55032724
27Collecting duct acid secretion_Homo sapiens_hsa049661.51324680
28Insulin secretion_Homo sapiens_hsa049111.49528636
29Protein digestion and absorption_Homo sapiens_hsa049741.44808789
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.43971844
31Galactose metabolism_Homo sapiens_hsa000521.42851265
32RNA polymerase_Homo sapiens_hsa030201.42036411
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39204679
34Primary immunodeficiency_Homo sapiens_hsa053401.37737766
35Glutathione metabolism_Homo sapiens_hsa004801.37190382
36Ether lipid metabolism_Homo sapiens_hsa005651.36791072
37Huntingtons disease_Homo sapiens_hsa050161.36060666
38Circadian rhythm_Homo sapiens_hsa047101.34638497
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33412981
40Lysosome_Homo sapiens_hsa041421.27166735
41Fat digestion and absorption_Homo sapiens_hsa049751.26336557
42Nitrogen metabolism_Homo sapiens_hsa009101.25206306
43Pyrimidine metabolism_Homo sapiens_hsa002401.22367962
44Autoimmune thyroid disease_Homo sapiens_hsa053201.21336309
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18186746
46Retinol metabolism_Homo sapiens_hsa008301.17689059
47Allograft rejection_Homo sapiens_hsa053301.16863565
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.15051421
49Alzheimers disease_Homo sapiens_hsa050101.14479830
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11272787
51Mineral absorption_Homo sapiens_hsa049781.06742136
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06666748
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06157794
54Graft-versus-host disease_Homo sapiens_hsa053321.05161012
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04636425
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00311017
57beta-Alanine metabolism_Homo sapiens_hsa004100.94626425
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93583900
59Renin-angiotensin system_Homo sapiens_hsa046140.89277795
60Type I diabetes mellitus_Homo sapiens_hsa049400.88651535
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88022461
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84754868
63Fructose and mannose metabolism_Homo sapiens_hsa000510.83822801
64Fatty acid metabolism_Homo sapiens_hsa012120.83425515
65Sphingolipid metabolism_Homo sapiens_hsa006000.82557557
66Rheumatoid arthritis_Homo sapiens_hsa053230.82058685
67Purine metabolism_Homo sapiens_hsa002300.80797179
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79370225
69Linoleic acid metabolism_Homo sapiens_hsa005910.76853643
70Steroid biosynthesis_Homo sapiens_hsa001000.75232102
71Fatty acid degradation_Homo sapiens_hsa000710.72980997
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.72477614
73Starch and sucrose metabolism_Homo sapiens_hsa005000.72390683
74Basal transcription factors_Homo sapiens_hsa030220.72019823
75One carbon pool by folate_Homo sapiens_hsa006700.71885563
76RNA degradation_Homo sapiens_hsa030180.71122144
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.70838371
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70308519
79Vitamin B6 metabolism_Homo sapiens_hsa007500.68082612
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67203534
81DNA replication_Homo sapiens_hsa030300.66471390
82Base excision repair_Homo sapiens_hsa034100.66120762
83Vitamin digestion and absorption_Homo sapiens_hsa049770.64908404
84Cell cycle_Homo sapiens_hsa041100.64264253
85Arachidonic acid metabolism_Homo sapiens_hsa005900.64094059
86Homologous recombination_Homo sapiens_hsa034400.60193734
87Hematopoietic cell lineage_Homo sapiens_hsa046400.60085593
88Serotonergic synapse_Homo sapiens_hsa047260.59442641
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58921835
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57370813
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56870747
92Proteasome_Homo sapiens_hsa030500.55082218
93Arginine and proline metabolism_Homo sapiens_hsa003300.54762021
94Thyroid hormone synthesis_Homo sapiens_hsa049180.54386194
95Type II diabetes mellitus_Homo sapiens_hsa049300.53480760
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53065258
97Legionellosis_Homo sapiens_hsa051340.52775603
98p53 signaling pathway_Homo sapiens_hsa041150.51327798
99Non-homologous end-joining_Homo sapiens_hsa034500.51256605
100Cocaine addiction_Homo sapiens_hsa050300.50346611
101Fanconi anemia pathway_Homo sapiens_hsa034600.50300376
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49164427
103Metabolic pathways_Homo sapiens_hsa011000.48568618
104Nucleotide excision repair_Homo sapiens_hsa034200.46851149
105Thyroid cancer_Homo sapiens_hsa052160.46210866
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46035119
107Cardiac muscle contraction_Homo sapiens_hsa042600.43826495
108Prolactin signaling pathway_Homo sapiens_hsa049170.43806372
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42940828
110Nicotine addiction_Homo sapiens_hsa050330.42511389
111Insulin resistance_Homo sapiens_hsa049310.42126550
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41916991
113Caffeine metabolism_Homo sapiens_hsa002320.40262369
114Mismatch repair_Homo sapiens_hsa034300.39644607
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39517037
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38852483
117Salivary secretion_Homo sapiens_hsa049700.38670780
118Ribosome_Homo sapiens_hsa030100.38013307
119GABAergic synapse_Homo sapiens_hsa047270.36255736
120Antigen processing and presentation_Homo sapiens_hsa046120.35849376
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32988933
122Glucagon signaling pathway_Homo sapiens_hsa049220.31751375
123Tryptophan metabolism_Homo sapiens_hsa003800.30596363
124Prostate cancer_Homo sapiens_hsa052150.30268730
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29481151
126RNA transport_Homo sapiens_hsa030130.29394429
127ABC transporters_Homo sapiens_hsa020100.25927497
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25553284
129Phagosome_Homo sapiens_hsa041450.23049250
130Ovarian steroidogenesis_Homo sapiens_hsa049130.22838107
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20970743
132Bladder cancer_Homo sapiens_hsa052190.20559903
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20435738
134Histidine metabolism_Homo sapiens_hsa003400.20241050
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20048243
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18278241
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18031273
138Taste transduction_Homo sapiens_hsa047420.16057635
139Peroxisome_Homo sapiens_hsa041460.15942882
140Amphetamine addiction_Homo sapiens_hsa050310.15840776
141Glycerolipid metabolism_Homo sapiens_hsa005610.15332578
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15179236
143Sulfur relay system_Homo sapiens_hsa041220.11869921
144FoxO signaling pathway_Homo sapiens_hsa040680.11079634
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10375649
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09110255
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.06742509

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »